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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDK3 Gene

protein-coding GIFtS: 57
GCID: GC17P073996

Cyclin-Dependent Kinase 3

Microbiology & Infectious Diseases Congress

6 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 3¹ ²
Cell Division Protein Kinase 3² ³
EC 2.7.11.22³ ⁸
CDKN3³
EC 2.7.11⁸

External Ids:	HGNC: 1772¹	Entrez Gene: 1018²	Ensembl: ENSG00000250506⁷	OMIM: 123828⁵	UniProtKB: Q00526³

Export aliases for CDK3 gene to outside databases

Previous GC identifers: GC17M073921 GC17P077001 GC17P074439 GC17P074572 GC17P074594 GC17P071486 GC17P073977 GC17P069422

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK3 Gene:

This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in

part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and

phosphorylates the retinoblastoma 1 protein to promote exit from G0. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDK3 Gene:

CDK3 (cyclin-dependent kinase 3) is a protein-coding gene. Diseases associated with CDK3 include retinoblastoma, and herpes simplex. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526

Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle;

involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates

histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities,

and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1

transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a

RB1-independent manner

Gene Wiki entry for CDK3 (Cyclin-dependent kinase 3) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NT_010783.15 NC_018928.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDK3 gene promoter:
HOXA9 HOXA9B AML1a Pax-5 RelA AP-4 CUTL1 Meis-1b NF-kappaB1 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK3 promoter sequence

Search SABiosciences Chromatin IP Primers for CDK3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1

CDK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK3 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P073996: view genomic region (about GC identifiers)

Start:	73,996,987 bp from pter	End:	74,002,080 bp from pter
Size:	5,094 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526 (See protein sequence)

Recommended Name: Cyclin-dependent kinase 3

Size: 305 amino acids; 35046 Da

Subunit: Interacts with CABLES1 and CABLES2 (By similarity). Interacts with ATF1. Binding to CCNC/cyclin-C promotes RB1

phosphorylation

1 PDB 3D structure from and Proteopedia for CDK3:

1LFN (3D)

Explore the universe of human proteins at neXtProt for CDK3: NX_Q00526

Explore proteomics data for CDK3 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q00526

4/17 DME Specific Peptides for CDK3 (Q00526) (see all 17)

VIHRDLK

VVTLWYR

DFGLARA

EGVPSTA

CDK3 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_001249.1

ENSEMBL proteins:

ENSP00000466237 ENSP00000410561 ENSP00000465062 ENSP00000400088

Human Recombinant Protein Products for CDK3:

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CDK3 Antibody Products:

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Assay Products for CDK3:

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	Cloud-Clone Corp. ELISAs for CDK3 Cloud-Clone Corp. CLIAs for CDK3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

CDK: Cyclin-dependent kinases

IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 3

CDK1 subfamily

5 InterPro protein domains:

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q00526

ProtoNet protein and cluster: Q00526

UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily

Similarity: Contains 1 protein kinase domain

CDK3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CDK3_HUMAN, Q00526

Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle;

involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates

histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities,

and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1

transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a

RB1-independent manner

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Genatlas biochemistry entry for CDK3:

cyclin dependent kinase 3,involved in cell cycle regulation (G1 to S transition),not complexing with any cyclin

Enzyme Numbers (IUBMB): EC 2.7.11.22¹ ² EC 2.7.11²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	--	--
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IEA	--
GO:0004713	protein tyrosine kinase activity	--	--
GO:0005524	ATP binding	IEA	--

CDK3 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for CDK3:

Actin fiber cells

Decreased substrate adherent c

Increased circadian period len

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK3

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK3

miRNA Products:		miRTarBase miRNAs that target CDK3: hsa-mir-146a (MIRT005705)


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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDK3
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		Sirion Biotech Customized stable knockdown cell line services for CDK3 Customized inducible knockdown cell line services for CDK3 Customized stable overexpressing cell line services for CDK3 Customized inducible overexpressing cell line services for CDK3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CDK3 About

See pathways by source

SuperPath

Contained pathways About

Cell Cycle Control of Chromosomal Replication

Cell Cycle Control of Chromosomal Replication

GADD45 Pathway

GADD45 Pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK3

	Cell Cycle Control of Chromosomal Replication
	GADD45 Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDK3

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/740 Interacting proteins for CDK3 (Q00526^{2, 3} ENSP00000400088⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 740)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=3
HIST1H4B	P62805³	I2D: score=3
HIST1H4C	P62805³	I2D: score=3
HIST1H4D	P62805³	I2D: score=3
HIST1H4E	P62805³	I2D: score=3

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	TAS	8846921
GO:0006468	protein phosphorylation	--	--
GO:0007067	mitosis	IEA	--
GO:0008283	cell proliferation	TAS	18794154
GO:0045023	G0 to G1 transition	TAS	15084261

CDK3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for CDK3:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDK3

2 HMDB Compounds for CDK3 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

Search CenterWatch for drugs/clinical trials and news about CDK3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDK3 gene:

NM_001258.2

Unigene Cluster for CDK3:

Cyclin-dependent kinase 3

Hs.706766 [show with all ESTs]

Unigene Representative Sequence: NR_037709

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000588812 ENST00000425876 ENST00000586261 ENST00000448471

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:
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		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK3:
		hsa-miR-512-5p hsa-miR-214 hsa-miR-634 hsa-miR-1207-3p hsa-miR-761
		SwitchGear 3'UTR luciferase reporter plasmid: CDK3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for CDK3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK3
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Clone Products:		OriGene clones in human, mouse for CDK3 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CDK3 (NM_001258)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK3

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for CDK3
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat CDK3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK3

Additional mRNA sequence:

NR_037709.1 X66357.1

6 DOTS entries:

DT.302659 DT.95164072 DT.92434871 DT.97768995 DT.121007869 DT.455141

24/138 AceView cDNA sequences (see all 138):

CK904002 CF128049 AU120188 CR604264 CD671351 BM053162 BC047782 BQ962463

BU785194 AI565655 BM907267 BM053101 BM671003 BM706946 BQ189457 AI131108

AI468903 BQ772353 X66357 BU728264 BU623401 BE782476 AI670081 AW612926

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CACGAGGGGT

About this image

See CDK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDK3

SOURCE GeneReport for Unigene cluster: Hs.706766

UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526

Tissue specificity: Expressed in cancer cell lines and glioblastoma tissue

SABiosciences Custom PCR Arrays for CDK3

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK3 gene from 13 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	CDK3¹	cyclin-dependent kinase 3	99.78(n) 99.67(a)		468331 XM_523720.3 XP_523720.2
mouse (Mus musculus)	Mammalia	Cdk3-ps⁵	cyclin-dependent kinase 3, pseudogene	--		11 (81.02 cM) 116216003
cow (Bos taurus)	Mammalia	CDK3¹	cyclin-dependent kinase 3	88.89(n) 89.11(a)		618631 NM_001099178.1 NP_001092648.1
dog (Canis familiaris)	Mammalia	CDK3¹	cyclin-dependent kinase 3	90.1(n) 91.72(a)		483323 XM_540442.3 XP_540442.3
oppossum (Monodelphis domestica)	Mammalia	CDK3⁶	cyclin-dependent kinase 3	85(a)	1 ↔ 1	2(212924056-212928973)
chicken (Gallus gallus)	Aves	CDK3¹	cyclin-dependent kinase 3	75.67(n) 81.33(a)		429642 NM_001081706.2 NP_001075175.2
lizard (Anolis carolinensis)	Reptilia	CDK3⁶	Uncharacterized protein	75(a)	1 ↔ 1	2(113303478-113320825)
sea squirt (Ciona savignyi)	Ascidiacea	CSA.5702⁶	Uncharacterized protein	64(a)	1 → many	reftig_27(1271989-1278761)
fruit fly (Drosophila melanogaster)	Insecta	cdc2³	G2/M transition of mitotic cell cycle protein more	65(a) (best of 4)		31D11 --
worm (Caenorhabditis elegans)	Secernentea	cdk-1³	serine/threonine kinase (CDC2/CDKX subfamily)	63(a) (best of 3)		III(9819189-9820383) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CDC28⁶	Catalytic subunit of the main cell cycle cyclin-de...	62(a)	1 → many	II(560078-560974)
soybean (Glycine max)	eudicotyledons	Gma.13118²	Glycine max cv Prize protein kinase mRNA.	74.36(n)		M93140.1
wheat (Triticum aestivum)	Liliopsida	Ta.6675²	Triticum aestivum p34cdc2 (cdc2TaB) mRNA, partial cds	78.66(n)		U23410.1

Species with no ortholog for CDK3

ENSEMBL Gene Tree for CDK3 (if available)
TreeFam Gene Tree for CDK3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDK3 gene

CDK18² CDK6² CDK5² CDK15² CDK1² CDK4² CDK14² CDK16²

CDK2² CDK17²

18/96 SIMAP similar genes for CDK3 using alignment to 3 protein entries: CDK3_HUMAN (see all proteins) (see all similar genes):

CDK1 CDC2 CDK5 DKFZp686L20222 CDK18 CDK2

PCTK1 PHKG2 CDK17 CDK16 STK3 PCTK3

CDK14 CDK15 NDUFA9 CDC2L2 CDK7 CDK6

CDK3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
VAR_041973⁴	A glioblastoma multiforme sample⁴	--	see VAR_041973	2	S N	mis⁴		0	--	--	--	--
VAR_041974⁴	--	--	see VAR_041974	2	I T	mis⁴		0	--	--	--	--
VAR_021102⁴	--	--	see VAR_021102	2	M T	mis⁴		0	--	--	--	--
VAR_021101⁴	--	--	see VAR_021101	2	T I	mis⁴		0	--	--	--	--
VAR_041975⁴	--	--	see VAR_041975	2	R H	mis⁴		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDK3 (73996987 - 74002080 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for CDK3: About this table

Variant ID	Type	Subtype	PubMed ID
nsv908826	CNV	Loss	21882294
nsv833546	CNV	Loss	17160897
nsv908825	CNV	Loss	21882294
nsv908824	CNV	Loss	21882294
dgv3270n71	CNV	Loss	21882294

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK3

DNA2.0 Custom Variant and Variant Library Synthesis for CDK3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDK3 for disorders           About GeneDecksing

OMIM gene information: 123828    OMIM disorders: --

6 diseases for CDK3:    About MalaCards

retinoblastoma herpes simplex glioblastoma sarcoma

hepatocellular carcinoma neuronitis

2 Novoseek inferred disease relationships for CDK3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	2	7882308 (2)
cancer	0	2	18794154 (1), 7882308 (1)

Export disorders for CDK3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDK3 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with CDK3)

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A family of human cdc2-related protein kinases. (PubMed id 1639063)^{1, 2, 3, 9} Meyerson M.... Tsai L.-H. (1992)
Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. (PubMed id 18794154)^{1, 2, 9} Zheng D....Dong Z. (2008)
Cyclin C/cdk3 promotes Rb-dependent G0 exit. (PubMed id 15084261)^{1, 2} Ren S. and Rollins B.J. (2004)
Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. (PubMed id 8846921)^{1, 2} Hofmann F. and Livingston D.M. (1996)
Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. (PubMed id 9811456)^{1, 9} Braun K....Hengstschlager M. (1998)
ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PubMed id 11733001)^{1, 9} Yamochi T....Matsuoka M. (2001)
Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. (PubMed id 7882308)^{1, 9} Bullrich F....Croce C.M. (1995)
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. (PubMed id 9190208)^{1, 9} Connell-Crowley L....Goodrich D.W. (1997)
Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells. (PubMed id 8626531)^{1, 9} Sasaguri T....Ogata J. (1996)
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. (PubMed id 8242750)^{1, 9} Gyuris J.... Brent R. (1993)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1018	HGNC: 1772	AceView: CDK3	Ensembl:ENSG00000250506	euGenes: HUgn1018
ECgene: CDK3	H-InvDB: CDK3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CDK3	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdk3/

Intellectual Property for CDK3 gene
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Patent Information for CDK3 gene:
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