CDK3 Gene

Aliases
for CDK3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC17M073921 GC17P077001 GC17P074439 GC17P074572 GC17P074594 GC17P071486 GC17P073977 GC17P069422

Summaries
for CDK3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CDK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK3

CDK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P073996:  view genomic region     (about GC identifiers)

Proteins
for CDK3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for CDK3:

1LFN (3D)    

Explore the universe of human proteins at neXtProt for CDK3: NX_Q00526

Explore proteomics data for CDK3 at MOPED

Post-translational modifications: 

CDK3 Human Recombinant Protein Products:

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	Cloud-Clone Corp. Proteins for CDK3
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	Search GeneTex for Proteins for CDK3
	antibodies-online proteins for CDK3 (4 products)
	antibodies-online peptides for CDK3

CDK3 Antibody Products:

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	antibodies-online antibodies for CDK3 (37 products)

CDK3 Assay Products:

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	Cloud-Clone Corp. ELISAs for CDK3 Cloud-Clone Corp. CLIAs for CDK3
	Search eBioscience for ELISAs for CDK3
	antibodies-online kits for CDK3 (2 products)

Domains /
Families
for CDK3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q00526

Find genes that share domains with CDK3           About GenesLikeMe

Function
for CDK3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

genOway: Develop your customized and physiologically relevant rodent model for CDK3

miRNA Products:		miRTarBase miRNAs that target CDK3: hsa-mir-215-5p (MIRT024518), hsa-mir-192-5p (MIRT026751), hsa-mir-146a-5p (MIRT005705), hsa-mir-92a-3p (MIRT049159)
		Block miRNA regulation of human, mouse, rat CDK3 using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate CDK3:
		hsa-miR-512-5p hsa-miR-214 hsa-miR-634 hsa-miR-1207-3p hsa-miR-761
		SwitchGear 3'UTR luciferase reporter plasmid: CDK3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CDK3
		Predesigned siRNA for gene silencing in human, mouse, rat CDK3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CDK3

Clone Products:		OriGene clones in human, mouse for CDK3 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CDK3 (NM_001258)
		Sino Biological Human cDNA Clone for CDK3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK3
		Addgene plasmids for CDK3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDK3
		Browse ESI BIO Cell Lines and PureStem Progenitors for CDK3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK3

Localization
for CDK3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Pathways & Interactions
for CDK3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for CDK3 About     See pathways by source

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	SuperPath	Contained pathways About
1	GADD45 Pathway	GADD45 Pathway
2	Cell Cycle Control of Chromosomal Replication	Cell Cycle Control of Chromosomal Replication

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDK3

	Cell Cycle Control of Chromosomal Replication
	GADD45 Pathway

Gene Ontology (GO): 5 biological process terms:    About this table

Drugs & Compounds
for CDK3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CDK3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CDK3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CDK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CACGAGGGGT

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for CDK3
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CDK3
		QuantiTect SYBR Green Assays in human, mouse, rat CDK3
		QuantiFast Probe-based Assays in human, mouse, rat CDK3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK3

Orthologs
for CDK3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CDK3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CDK3 gene

CDK6²  CDK2²  CDK4²  CDK1²  

Selected SIMAP similar genes for CDK3 using alignment to 3 protein entries:     CDK3_HUMAN (see all proteins) (see all similar genes):

CDK1    CDC2    CDK5    DKFZp686L20222    CDK18    CDK2

PCTK1    PHKG2    CDK17    CDK16    STK3    PCTK3

CDK14    CDK15    CDC2L2    CDK7    CDK6    CDC2L1

Find genes that share paralogs with CDK3           About GenesLikeMe

Genomic Variants
for CDK3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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5 SNPs for CDK3    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
VAR_0419734		A glioblastoma multiforme sample4	--	see VAR_041973	2	S N	mis4		0	--	--	--	--
rs349184461,2,4		--	--	see VAR_041974	2		mis4		0	--	--	--	--
rs178842511,2,4		--	--	see VAR_021102	2		mis4		0	--	--	--	--
rs20695321,2,4		--	--	see VAR_021101	2		mis4		0	--	--	--	--
rs346702671,2,4		--	--	see VAR_041975	2		mis4		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDK3 (73996987 - 74002080 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for CDK3:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv908826	CNV	Loss	21882294
nsv833546	CNV	Loss	17160897
nsv908825	CNV	Loss	21882294
nsv908824	CNV	Loss	21882294
dgv3270n71	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing CDK3

DNA2.0 Custom Variant and Variant Library Synthesis for CDK3

Disorders / Diseases
for CDK3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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2 Novoseek inferred disease relationships for CDK3 gene    About this table

Publications
for CDK3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. A family of human cdc2-related protein kinases. (PubMed id 1639063)^{1, 2, 3, 9} Meyerson M.... Tsai L.-H. (EMBO J. 1992)
2. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. (PubMed id 18794154)^{1, 2, 9} Zheng D....Dong Z. (Cancer Res. 2008)
3. Cyclin C/cdk3 promotes Rb-dependent G0 exit. (PubMed id 15084261)^{1, 2} Ren S. and Rollins B.J. (Cell 2004)
4. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. (PubMed id 8846921)^{1, 2} Hofmann F. and Livingston D.M. (Genes Dev. 1996)
5. Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. (PubMed id 9811456)^{1, 9} Braun K....HengstschlAoger M. (Oncogene 1998)
6. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PubMed id 11733001)^{1, 9} Yamochi T....Matsuoka M. (Eur. J. Biochem. 2001)
7. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. (PubMed id 7882308)^{1, 9} Bullrich F....Croce C.M. (Cancer Res. 1995)
8. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. (PubMed id 9190208)^{1, 9} Connell-Crowley L....Goodrich D.W. (Mol. Biol. Cell 1997)
9. Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells. (PubMed id 8626531)^{1, 9} Sasaguri T....Ogata J. (J. Biol. Chem. 1996)
10. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. (PubMed id 8242750)^{1, 9} Gyuris J.... Brent R. (Cell 1993)

External Searches for CDK3 gene

Genome Databases showing CDK3 gene

Other Databases showing CDK3 gene

Specialized Databases showing CDK3 gene

Products
for CDK3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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