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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK3 Gene

protein-coding   GIFtS: 57
GCID: GC17P073996

Cyclin-Dependent Kinase 3
Microbiology & Infectious Diseases Congress
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Aliases
for CDK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase 31 2
Cell Division Protein Kinase 32 3
EC 2.7.11.223 8
CDKN33
EC 2.7.118

External Ids:    HGNC: 17721   Entrez Gene: 10182   Ensembl: ENSG000002505067   OMIM: 1238285   UniProtKB: Q005263   

Export aliases for CDK3 gene to outside databases

Previous GC identifers: GC17M073921 GC17P077001 GC17P074439 GC17P074572 GC17P074594 GC17P071486 GC17P073977 GC17P069422


Summaries
for CDK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDK3 Gene:
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase,
in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin
C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDK3 Gene: 
CDK3 (cyclin-dependent kinase 3) is a protein-coding gene. Diseases associated with CDK3 include retinoblastoma, and herpes simplex. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526
Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle;
involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates
histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional
activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is
required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2
and E2F3 in a RB1-independent manner

Gene Wiki entry for CDK3 (Cyclin-dependent kinase 3) Gene


Genomic Views
for CDK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK3 gene promoter:
         HOXA9   HOXA9B   AML1a   Pax-5   RelA   AP-4   CUTL1   Meis-1b   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

CDK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P073996:  view genomic region     (about GC identifiers)

Start:
 73,996,987 bp from pter      End:
 74,002,080 bp from pter
Size:
 5,094 bases      Orientation:
 plus strand

Proteins
for CDK3 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 3  
Size: 305 amino acids; 35046 Da
Subunit: Interacts with CABLES1 and CABLES2 (By similarity). Interacts with ATF1. Binding to CCNC/cyclin-C
promotes RB1 phosphorylation
1 PDB 3D structure from and Proteopedia for CDK3:
1LFN (3D)    

Explore the universe of human proteins at neXtProt for CDK3: NX_Q00526

Explore proteomics data for CDK3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q00526

    • 4/17 DME Specific Peptides for CDK3 (Q00526) (see all 17)
     VIHRDLK  VVTLWYR  DFGLARA  EGVPSTA 

    CDK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK3 Protein Expression
    REFSEQ proteins: NP_001249.1  
    ENSEMBL proteins: 
     ENSP00000466237   ENSP00000410561   ENSP00000465062   ENSP00000400088  

    Human Recombinant Protein Products for CDK3: 
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    OriGene Protein Over-expression Lysate for CDK3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CDK3
    GenScript Custom Purified and Recombinant Proteins Services for CDK3
    Novus Biologicals CDK3 Proteins
    Novus Biologicals CDK3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK3 


    CDK3 Antibody Products: 
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    Novus Biologicals CDK3 Antibodies
    Abcam antibodies for CDK3
    Cloud-Clone Corp. Antibodies for CDK3 
    ThermoFisher Antibodies for CDK3
    LSBio Antibodies in human, mouse, rat for CDK3 

    Assay Products for CDK3: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CDK3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK3 
    Cloud-Clone Corp. CLIAs for CDK3

    Protein Domains /
    Families
    for CDK3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 3 
    CDK1 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q00526

    ProtoNet protein and cluster: Q00526

    UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK3 for domains           About GeneDecksing


    Function
    for CDK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK3_HUMAN, Q00526
    Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle;
    involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates
    histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional
    activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is
    required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2
    and E2F3 in a RB1-independent manner
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for CDK3:
    cyclin dependent kinase 3,involved in cell cycle regulation (G1 to S transition),not complexing with any cyclin

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    CDK3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDK3:
     Actin fiber cells  Decreased substrate adherent c  Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK3 

    miRNA
    Products:            		miRTarBase miRNAs that target CDK3:
    hsa-mir-146a (MIRT005705)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK3
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK3:
    hsa-miR-512-5p hsa-miR-214 hsa-miR-634 hsa-miR-1207-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: CDK3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CDK3
    Sirion Biotech Customized adenovirus for overexpression of CDK3

    Clone
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    OriGene clones in human, mouse for CDK3 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDK3 (NM_001258)
    Sino Biological Human cDNA Clone for CDK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK3
    Sirion Biotech Customized lentivirus for stable overexpression of CDK3 
                         Customized lentivirus expression plasmids for stable overexpression of CDK3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CDK3
    Search LifeMap BioReagents cell lines for CDK3
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK3


    Pathways & Interactions
    for CDK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell Cycle Control of Chromosomal Replication
    		Cell Cycle Control of Chromosomal Replication
    2GADD45 Pathway
    		GADD45 Pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK3
        Cell Cycle Control of Chromosomal Replication
    GADD45 Pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/740 Interacting proteins for CDK3 (Q005262, 3 ENSP000004000884) via UniProtKB, MINT, STRING, and/or I2D (see all 740)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS8846921
    GO:0006468protein phosphorylation ----
    GO:0007067mitosis IEA--
    GO:0008283cell proliferation TAS18794154
    GO:0045023G0 to G1 transition TAS15084261

    CDK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for CDK3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK3

    2 HMDB Compounds for CDK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about CDK3

    Transcripts
    for CDK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDK3 gene: 
    NM_001258.2  

    Unigene Cluster for CDK3:

    Cyclin-dependent kinase 3
    Hs.706766  [show with all ESTs]
    Unigene Representative Sequence: NR_037709
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588812 ENST00000425876 ENST00000586261 ENST00000448471
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK3
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK3:
    hsa-miR-512-5p hsa-miR-214 hsa-miR-634 hsa-miR-1207-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: CDK3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK3
    Clone
    Products:             		 OriGene clones in human, mouse for CDK3 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDK3 (NM_001258)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK3
    Sirion Biotech Customized lentivirus for stable overexpression of CDK3 
                         Customized lentivirus expression plasmids for stable overexpression of CDK3 
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for CDK3
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CDK3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK3

    Additional mRNA sequence: 

    NR_037709.1 X66357.1 

    6 DOTS entries:

    DT.302659  DT.95164072  DT.92434871  DT.97768995  DT.121007869  DT.455141 

    24/138 AceView cDNA sequences (see all 138):

    CK904002 CF128049 AU120188 CR604264 CD671351 BM053162 BC047782 BQ962463 
    BU785194 AI565655 BM907267 BM053101 BM671003 BM706946 BQ189457 AI131108 
    AI468903 BQ772353 X66357 BU728264 BU623401 BE782476 AI670081 AW612926 

    GeneLoc Exon Structure


    Expression
    for CDK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGAGGGGT
    CDK3 Expression
    About this image


    See CDK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK3

    SOURCE GeneReport for Unigene cluster: Hs.706766

    UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526
    Tissue specificity: Expressed in cancer cell lines and glioblastoma tissue

        SABiosciences Custom PCR Arrays for CDK3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK3

    Orthologs
    for CDK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK3 gene from 13 species (see representative species )    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chimpanzee
    (Pan troglodytes)    		 Mammalia CDK31 cyclin-dependent kinase 3 99.78(n)
    99.67(a)    		   468331  XM_523720.3  XP_523720.2 
    mouse
    (Mus musculus)    		 Mammalia Cdk3-ps5 cyclin-dependent kinase 3, pseudogene   --   11 (81.02 cM) 116216003 
    cow
    (Bos taurus)    		 Mammalia CDK31 cyclin-dependent kinase 3 88.89(n)
    89.11(a)    		   618631  NM_001099178.1  NP_001092648.1 
    dog
    (Canis familiaris)    		 Mammalia CDK31 cyclin-dependent kinase 3 90.1(n)
    91.72(a)    		   483323  XM_540442.3  XP_540442.3 
    oppossum
    (Monodelphis domestica)    		 Mammalia CDK36
    		 cyclin-dependent kinase 3
    		 85(a)
    		 1 ↔ 1
    		 2(212924056-212928973)
    chicken
    (Gallus gallus)    		 Aves CDK31 cyclin-dependent kinase 3 75.67(n)
    81.33(a)    		   429642  NM_001081706.2  NP_001075175.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CDK36
    		 Uncharacterized protein
    		 75(a)
    		 1 ↔ 1
    		 2(113303478-113320825)
    sea squirt
    (Ciona savignyi)    		 Ascidiacea CSA.57026
    		 Uncharacterized protein
    		 64(a)
    		 1 → many
    		 reftig_27(1271989-1278761)
    fruit fly
    (Drosophila melanogaster)    		 Insecta cdc23 G2/M transition of mitotic cell cycle
    protein more    		 65(a)
    (best of 4)    		   31D11   --
    worm
    (Caenorhabditis elegans)    		 Secernentea cdk-13 serine/threonine kinase (CDC2/CDKX
    subfamily)    		 63(a)
    (best of 3)    		   III(9819189-9820383)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CDC286
    		 Catalytic subunit of the main cell cycle cyclin-de...
    		 62(a)
    		 1 → many
    		 II(560078-560974)
    soybean
    (Glycine max)    		 eudicotyledons Gma.131182 Glycine max cv Prize protein kinase mRNA. 74.36(n)    M93140.1 
    wheat
    (Triticum aestivum)    		 Liliopsida Ta.66752 Triticum aestivum p34cdc2 (cdc2TaB) mRNA, partial cds 78.66(n)    U23410.1 
            Species with no ortholog for CDK3

    ENSEMBL Gene Tree for CDK3 (if available)
    TreeFam Gene Tree for CDK3 (if available)

    Paralogs
    for CDK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK3 gene
    CDK182  CDK62  CDK52  CDK152  CDK12  CDK42  CDK142  CDK162  
    CDK22  CDK172  
    18/96 SIMAP similar genes for CDK3 using alignment to 3 protein entries:     CDK3_HUMAN (see all proteins) (see all similar genes):
    CDK1    CDC2    CDK5    DKFZp686L20222    CDK18    CDK2
    PCTK1    PHKG2    CDK17    CDK16    STK3    PCTK3
    CDK14    CDK15    NDUFA9    CDC2L2    CDK7    CDK6

    CDK3 for paralogs           About GeneDecksing



    Genomic Variants
    for CDK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    5 SNPs in CDK3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0419734
    		A glioblastoma multiforme sample4--see VAR_0419732 S N mis40--------
    VAR_0419744
    		----see VAR_0419742 I T mis40--------
    VAR_0211024
    		----see VAR_0211022 M T mis40--------
    VAR_0211014
    		----see VAR_0211012 T I mis40--------
    VAR_0419754
    		----see VAR_0419752 R H mis40--------

    HapMap Linkage Disequilibrium report for CDK3 (73996987 - 74002080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CDK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908826CNV Loss21882294
    nsv833546CNV Loss17160897
    nsv908825CNV Loss21882294
    nsv908824CNV Loss21882294
    dgv3270n71CNV Loss21882294

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    Disorders / Diseases
    for CDK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 123828    OMIM disorders: --

    6 diseases for CDK3:    About MalaCards
    retinoblastoma    herpes simplex    glioblastoma    sarcoma
    hepatocellular carcinoma    neuronitis


    CDK3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CDK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 7882308 (2)
    cancer 0 2 18794154 (1), 7882308 (1)


    Export disorders for CDK3 gene to outside databases

    Publications
    for CDK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK3 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with CDK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3, 9 Meyerson M.... Tsai L.-H. (1992)
    2. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. (PubMed id 18794154)1, 2, 9 Zheng D....Dong Z. (2008)
    3. Cyclin C/cdk3 promotes Rb-dependent G0 exit. (PubMed id 15084261)1, 2 Ren S. and Rollins B.J. (2004)
    4. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. (PubMed id 8846921)1, 2 Hofmann F. and Livingston D.M. (1996)
    5. Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. (PubMed id 9811456)1, 9 Braun K....Hengstschlager M. (1998)
    6. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PubMed id 11733001)1, 9 Yamochi T....Matsuoka M. (2001)
    7. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. (PubMed id 7882308)1, 9 Bullrich F....Croce C.M. (1995)
    8. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. (PubMed id 9190208)1, 9 Connell-Crowley L....Goodrich D.W. (1997)
    9. Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells. (PubMed id 8626531)1, 9 Sasaguri T....Ogata J. (1996)
    10. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. (PubMed id 8242750)1, 9 Gyuris J.... Brent R. (1993)

    External Searches for CDK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1018 HGNC: 1772 AceView: CDK3 Ensembl:ENSG00000250506 euGenes: HUgn1018
    ECgene: CDK3 H-InvDB: CDK3

    Other Databases showing CDK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk3/

    Intellectual Property
    for CDK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDK3 gene:
    Search GeneIP for patents involving CDK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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