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CDK3 Gene(Protein Coding)

Cyclin Dependent Kinase 3

GCID:
GC17P076006
GIFtS:
58
Genes Participants
UDN Logo

Aliases for CDK3 Gene

Aliases for CDK3 Gene

  • Cyclin Dependent Kinase 3 2 3 5
  • EC 2.7.11.22 4 61
  • Cell Division Protein Kinase 3 4
  • EC 2.7.11 61
  • CDKN3 4

External Ids for CDK3 Gene

Previous GeneCards Identifiers for CDK3 Gene

  • GC17M073921
  • GC17P077001
  • GC17P074439
  • GC17P074572
  • GC17P074594
  • GC17P071486
  • GC17P073977
  • GC17P069422
  • GC17P073996

Summaries for CDK3 Gene

Entrez Gene Summary for CDK3 Gene

  • This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK3 Gene

CDK3 (Cyclin Dependent Kinase 3) is a Protein Coding gene. Diseases associated with CDK3 include Star Syndrome. Among its related pathways are Cell Cycle Control of Chromosomal Replication and GADD45 Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK2.

UniProtKB/Swiss-Prot for CDK3 Gene

  • Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Gene Wiki entry for CDK3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK3 Gene

Genomics for CDK3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CDK3 Gene

Enhancers for CDK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G076513 2 FANTOM5 Ensembl ENCODE dbSUPER 25 +514.8 514848 5.4 HDGF PKNOX1 ARNT WRNIP1 SIN3A FEZF1 YBX1 ZNF2 ZNF416 ZNF207 UNK ENSG00000267342 TRIM65 ENSG00000266980 ENSG00000267546 CDK3 ENSG00000267801 METTL23 LINC02080 MYO15B
GH17G076734 2.7 Ensembl ENCODE dbSUPER 13.4 +736.4 736353 7.8 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 UNK MXRA7 ENSG00000267342 ENSG00000267546 CDK3 H3F3B ENSG00000266980 TRIM65 PRCD ENSG00000272386
GH17G076026 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.9 +27.3 27284 4.4 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 NT5C NUP85 UNK ENSG00000266980 CDK3 TEN1 METTL23 MYO15B KCTD2 MFSD11
GH17G075288 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -707.2 -707248 11.0 CREB3L1 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 GRB2 NUP85 SUMO2 CDK3 H3F3B TMEM94 ENSG00000267342 LLGL2 UNK TEN1
GH17G076480 2 FANTOM5 Ensembl ENCODE dbSUPER 13.4 +482.4 482434 6.1 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARID4B DMAP1 ZNF2 YY1 SLC30A9 RHBDF2 UNK AANAT CDK3 UBE2O ENSG00000267342 ENSG00000267801 TRIM65 GC17P076469 GC17M076496
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDK3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CDK3 gene promoter:

Genomic Location for CDK3 Gene

Chromosome:
17
Start:
76,000,906 bp from pter
End:
76,005,999 bp from pter
Size:
5,094 bases
Orientation:
Plus strand

Genomic View for CDK3 Gene

Genes around CDK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CDK3 Gene

Proteins for CDK3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CDK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00526-CDK3_HUMAN
    Recommended name:
    Cyclin-dependent kinase 3
    Protein Accession:
    Q00526

    Protein attributes for CDK3 Gene

    Size:
    305 amino acids
    Molecular mass:
    35046 Da
    Quaternary structure:
    • Interacts with CABLES1 and CABLES2 (By similarity). Interacts with ATF1. Binding to CCNC/cyclin-C promotes RB1 phosphorylation.

    Three dimensional structures from OCA and Proteopedia for CDK3 Gene

neXtProt entry for CDK3 Gene

Protein Expression for CDK3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CDK3 Gene

Q00526:
  • WSIGCIFAE
  • GCIFAEM
  • FCHSHRV
  • TAIREIS
  • DFGLARA
  • EVVTLWYRAP
  • VVTLWYR
  • EGVPSTA
  • LADFGLA
  • DFGLARAFG
  • SEIDQLF
  • HRDLKPQN
  • VIHRDLK
  • FQKVEKIGEGTYGVVYKA
  • VALKKIR
  • IGEGTYG
  • KLYLVFE

Post-translational modifications for CDK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CDK3

Domains & Families for CDK3 Gene

Gene Families for CDK3 Gene

HGNC:
IUPHAR :

Protein Domains for CDK3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00526

UniProtKB/Swiss-Prot:

CDK3_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK3: view

Function for CDK3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CDK3 Gene

GENATLAS Biochemistry:
cyclin dependent kinase 3,involved in cell cycle regulation (G1 to S transition),not complexing with any cyclin
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Enzyme Numbers (IUBMB) for CDK3 Gene

Gene Ontology (GO) - Molecular Function for CDK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA,TAS --
GO:0005515 protein binding IPI 23602568
genes like me logo Genes that share ontologies with CDK3: view
genes like me logo Genes that share phenotypes with CDK3: view

Animal Model Products

CRISPR Products

miRNA for CDK3 Gene

miRTarBase miRNAs that target CDK3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDK3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK3 Gene

Localization for CDK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK3 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for CDK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CDK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK3 Gene

Pathways & Interactions for CDK3 Gene

genes like me logo Genes that share pathways with CDK3: view

Pathways by source for CDK3 Gene

1 GeneTex pathway for CDK3 Gene

SIGNOR curated interactions for CDK3 Gene

Activates:
Inactivates:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS 8846921
GO:0006468 protein phosphorylation IBA,IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 24550317
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with CDK3: view

Drugs & Compounds for CDK3 Gene

Products:

  1. Drug

(7) Drugs for CDK3 Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
AT7519 Investigational Pharma Multi-CDK inhibitor 0
RGB-286638 Pharma CDKs inhibitor 0
PF-562271 Pharma ATP-competitive FAK inhibitor, reversible 0
RGB-286638 free base Pharma 0

(1) Additional Compounds for CDK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0

(4) ApexBio Compounds for CDK3 Gene

Compound Action Cas Number
AT7519 Multi-CDK inhibitor 844442-38-2
PF-562271 ATP-competitive FAK inhibitor, reversible 717907-75-0
RGB-286638 CDKs inhibitor 784210-87-3
RGB-286638 free base 784210-88-4
genes like me logo Genes that share compounds with CDK3: view

Drug Products

Transcripts for CDK3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CDK3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(138) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDK3 Gene

Cyclin-dependent kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDK3

Alternative Splicing Database (ASD) splice patterns (SP) for CDK3 Gene

No ASD Table

Relevant External Links for CDK3 Gene

GeneLoc Exon Structure for
CDK3
ECgene alternative splicing isoforms for
CDK3

Expression for CDK3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK3 Gene

mRNA expression in normal human tissues for CDK3 Gene
mRNA expression by BioGPS for CDK3 GenemRNA expression by GTEx for CDK3 Gene

Protein differential expression in normal tissues from HIPED for CDK3 Gene

This gene is overexpressed in Lymph node (30.5), CD8 Tcells (17.3), CD4 Tcells (9.6), and Uterus (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK3 Gene



NURSA nuclear receptor signaling pathways regulating expression of CDK3 Gene:

CDK3

SOURCE GeneReport for Unigene cluster for CDK3 Gene:

Hs.706766

mRNA Expression by UniProt/SwissProt for CDK3 Gene:

Q00526-CDK3_HUMAN
Tissue specificity: Expressed in cancer cell lines and glioblastoma tissue.

Evidence on tissue expression from TISSUES for CDK3 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with CDK3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK3 Gene

Orthologs for CDK3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CDK3 34 35
  • 99.78 (n)
dog
(Canis familiaris)
 Mammalia CDK3 34 35
  • 90.1 (n)
cow
(Bos Taurus)
 Mammalia CDK3 34 35
  • 88.89 (n)
oppossum
(Monodelphis domestica)
 Mammalia CDK3 35
  • 85 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Cdk3-ps 35
  • 83 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CDK3 34 35
  • 75.67 (n)
lizard
(Anolis carolinensis)
 Reptilia CDK3 35
  • 75 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii si:dkeyp-57f11.1 35
  • 38 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta cdc2 36
  • 65 (a)
cdc2c 36 35
  • 65 (a)
Cdk4 36
  • 45 (a)
CG6800 36
  • 36 (a)
worm
(Caenorhabditis elegans)
 Secernentea cdk-1 36
  • 63 (a)
cdk-4 36
  • 36 (a)
H01G02.2 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CDC28 35
  • 62 (a)
 OneToMany
soybean
(Glycine max)
 eudicotyledons Gma.13118 34
wheat
(Triticum aestivum)
 Liliopsida Ta.6675 34
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.5702 35
  • 64 (a)
 OneToMany
Species where no ortholog for CDK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for CDK3 Gene

ENSEMBL:
Gene Tree for CDK3 (if available)
TreeFam:
Gene Tree for CDK3 (if available)

Paralogs for CDK3 Gene

Paralogs for CDK3 Gene

(94) SIMAP similar genes for CDK3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDK3: view

Variants for CDK3 Gene

Sequence variations from dbSNP and Humsavar for CDK3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_041973 A glioblastoma multiforme sample
rs1000606997 -- 76,000,518(+) CCGTG(C/T)TTGGT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001185304 -- 76,001,695(+) CTTCT(A/G)ACCAG intron-variant
rs1001427164 -- 76,002,031(+) CTGGA(C/T)GTGGT nc-transcript-variant, reference, synonymous-codon
rs1001956787 -- 76,006,054(+) GAACA(C/T)TGACA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CDK3 Gene

Variant ID Type Subtype PubMed ID
nsv833546 CNV loss 17160897

Variation tolerance for CDK3 Gene

Residual Variation Intolerance Score: 62.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK3 Gene

Disorders for CDK3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
star syndrome
  • toe syndactyly, telecanthus, and anogenital and renal malformations
- elite association - COSMIC cancer census association via MalaCards
Search CDK3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK3
genes like me logo Genes that share disorders with CDK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK3 Gene

Publications for CDK3 Gene

  1. A family of human cdc2-related protein kinases. (PMID: 1639063) Meyerson M. … Tsai L.-H. (EMBO J. 1992) 2 3 4 22 64
  2. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. (PMID: 18794154) Zheng D. … Dong Z. (Cancer Res. 2008) 3 4 22 64
  3. Cyclin C/cdk3 promotes Rb-dependent G0 exit. (PMID: 15084261) Ren S. … Rollins B.J. (Cell 2004) 3 4 64
  4. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PMID: 11733001) Yamochi T. … Matsuoka M. (Eur. J. Biochem. 2001) 3 22 64
  5. Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. (PMID: 9811456) Braun K. … HengstschlAoger M. (Oncogene 1998) 3 22 64

Products for CDK3 Gene

  • Addgene plasmids for CDK3

Sources for CDK3 Gene

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