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CDK3 Gene

protein-coding   GIFtS: 53
GCID: GC17P073996

Cyclin-Dependent Kinase 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 31 2
Cell Division Protein Kinase 32 3
EC 2.7.11.223 8
CDKN33
EC 2.7.118

External Ids:    HGNC: 17721   Entrez Gene: 10182   Ensembl: ENSG000002505067   OMIM: 1238285   UniProtKB: Q005263   

Export aliases for CDK3 gene to outside databases

Previous GC identifers: GC17M073921 GC17P077001 GC17P074439 GC17P074572 GC17P074594 GC17P071486 GC17P073977 GC17P069422


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK3 Gene:
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase,
in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin
C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDK3 Gene:
CDK3 (cyclin-dependent kinase 3) is a protein-coding gene. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK6.

UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526
Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle;
involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates
histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional
activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is
required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2
and E2F3 in a RB1-independent manner

Gene Wiki entry for CDK3 (Cyclin-dependent kinase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CDK3 gene promoter:
         HOXA9   HOXA9B   AML1a   Pax-5   RelA   AP-4   CUTL1   Meis-1b   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK3 promoter sequence
   Search Chromatin IP Primers for CDK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

CDK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P073996:  view genomic region     (about GC identifiers)

Start:
73,996,987 bp from pter      End:
74,002,080 bp from pter
Size:
5,094 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 3  
Size: 305 amino acids; 35046 Da
Subunit: Interacts with CABLES1 and CABLES2 (By similarity). Interacts with ATF1. Binding to CCNC/cyclin-C
promotes RB1 phosphorylation
1 PDB 3D structure from and Proteopedia for CDK3:
1LFN (3D)    

Explore the universe of human proteins at neXtProt for CDK3: NX_Q00526

Explore proteomics data for CDK3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys9
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK3 (Q00526) (see all 17)
     VIHRDLK  VVTLWYR  DFGLARA  EGVPSTA 


    See CDK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001249.1  
    ENSEMBL proteins: 
     ENSP00000466237   ENSP00000410561   ENSP00000465062   ENSP00000400088  

    CDK3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CDK3 Protein
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    OriGene Protein Over-expression Lysate for CDK3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CDK3
    GenScript Custom Purified and Recombinant Proteins Services for CDK3
    Novus Biologicals CDK3 Proteins
    Novus Biologicals CDK3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CDK3
    Cloud-Clone Corp. Proteins for CDK3

     
    Search eBioscience for Proteins for CDK3 

    CDK3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CDK3
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    Search for Antibodies for CDK3 at Abcam
    Cloud-Clone Corp. Antibodies for CDK3
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    LSBio Antibodies in human, mouse, rat for CDK3

    CDK3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK3
    Cloud-Clone Corp. CLIAs for CDK3
    Search eBioscience for ELISAs for CDK3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 3
    CDK1 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q00526

    ProtoNet protein and cluster: Q00526

    UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK3_HUMAN, Q00526
    Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle;
    involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates
    histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional
    activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is
    required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2
    and E2F3 in a RB1-independent manner
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for CDK3:
    cyclin dependent kinase 3,involved in cell cycle regulation (G1 to S transition),not complexing with any cyclin

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CDK3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDK3:
     Actin fiber cells  Decreased substrate adherent c  Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK3:
    hsa-mir-215-5p (MIRT024518), hsa-mir-192-5p (MIRT026751), hsa-mir-146a-5p (MIRT005705), hsa-mir-92a-3p (MIRT049159)

    Block miRNA regulation of human, mouse, rat CDK3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CDK3:
    hsa-miR-512-5p hsa-miR-214 hsa-miR-634 hsa-miR-1207-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidCDK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDK3
    Predesigned siRNA for gene silencing in human, mouse, rat CDK3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDK3

    Clone
    Products:
         
    OriGene clones in human, mouse for CDK3 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDK3 (NM_001258)
    Sino Biological Human cDNA Clone for CDK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK3
    Addgene plasmids for CDK3 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CDK3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK3 About    
    See pathways by source

    SuperPathContained pathways About
    1GADD45 Pathway
    GADD45 Pathway
    2Cell Cycle Control of Chromosomal Replication
    Cell Cycle Control of Chromosomal Replication

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDK3
        Cell Cycle Control of Chromosomal Replication
    GADD45 Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK3
    Interactions:

        GeneGlobe Interaction Network for CDK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK3 (Q005262, 3 ENSP000004000884) via UniProtKB, MINT, STRING, and/or I2D (see all 921) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    HIST1H4FP628053I2D: score=3 
    HIST1H4HP628053I2D: score=3 
    HIST1H4IP628053I2D: score=3 
    HIST1H4JP628053I2D: score=3 
    HIST1H4KP628053I2D: score=3 
    HIST1H4LP628053I2D: score=3 
    HIST2H4AP628053I2D: score=3 
    HIST2H4BP628053I2D: score=3 
    HIST4H4P628053I2D: score=3 
    CDKN3Q166672, 3, ENSP000003353574MINT-17536 I2D: score=3 STRING: ENSP00000335357
    CDC16Q130422, 3, ENSP000003485544MINT-7945693 I2D: score=1 STRING: ENSP00000348554
    CDC23Q9UJX22, 3, ENSP000003783504MINT-7945693 I2D: score=1 STRING: ENSP00000378350
    DNAJA1P316892, 3, ENSP000003691274MINT-7945693 I2D: score=1 STRING: ENSP00000369127
    ENSG00000258947Q135092, 3MINT-7945693 I2D: score=1 
    MSH6P527012, 3, ENSP000002344204MINT-7945693 I2D: score=1 STRING: ENSP00000234420
    PLK1P533502, 3, ENSP000003000934MINT-7945693 I2D: score=1 STRING: ENSP00000300093
    PSMC5P621952, 3, ENSP000003105724MINT-7945693 I2D: score=1 STRING: ENSP00000310572
    SMC4Q9NTJ32, 3, ENSP000003413824MINT-7945693 I2D: score=1 STRING: ENSP00000341382
    TUBB3Q135092, 3MINT-7945693 I2D: score=1 
    PSMD2Q132002, 3MINT-7945693 I2D: score=4 
    TCP1P179872, 3MINT-7945693 I2D: score=4 
    HSPD1P108092, 3MINT-7945693 I2D: score=2 
    ATRQ135352, 3MINT-7945693 I2D: score=1 
    BUB1O436832, 3MINT-7945693 I2D: score=1 
    CCT2P783712, 3MINT-7945693 I2D: score=1 
    CCT3P493682, 3MINT-7945693 I2D: score=1 
    CCT7Q998322, 3MINT-7945693 I2D: score=1 
    CDC27P302602, 3MINT-7945693 I2D: score=1 
    DDX19AQ9NUU72, 3MINT-7945693 I2D: score=1 
    DIAPH1O606102, 3MINT-7945693 I2D: score=1 
    EEF1A1P681042, 3MINT-7945693 I2D: score=1 
    EIF2S1P051982, 3MINT-7945693 I2D: score=1 
    EIF2S2P200422, 3MINT-7945693 I2D: score=1 
    EXOSC10Q017802, 3MINT-7945693 I2D: score=1 
    FEN1P397482, 3MINT-7945693 I2D: score=1 
    GCN1L1Q926162, 3MINT-7945693 I2D: score=1 
    HLTFQ145272, 3MINT-7945693 I2D: score=1 
    KIF11P527322, 3MINT-7945693 I2D: score=1 
    MLH1P406922, 3MINT-7945693 I2D: score=1 
    MSH2P432462, 3MINT-7945693 I2D: score=1 
    NCAPD2Q150212, 3MINT-7945693 I2D: score=1 
    PSMD1Q994602, 3MINT-7945693 I2D: score=1 
    RBBP5Q152912, 3MINT-7945693 I2D: score=1 
    RFC3P409382, 3MINT-7945693 I2D: score=1 
    RPL4P365782, 3MINT-7945693 I2D: score=1 
    RPLP0P053882, 3MINT-7945693 I2D: score=1 
    RPS3P233962, 3MINT-7945693 I2D: score=1 
    RUVBL1Q9Y2652, 3MINT-7945693 I2D: score=1 
    TUBA4AP683662, 3MINT-7945693 I2D: score=1 
    UPF1Q929002, 3MINT-7945693 I2D: score=1 
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    MRE11AP499592, 3, ENSP000003258634MINT-7945693 I2D: score=1 STRING: ENSP00000325863
    PSMC2P359982, 3, ENSP000002926444MINT-7945693 I2D: score=3 STRING: ENSP00000292644
    POLR2AP249282, 3, ENSP000003149494MINT-7945693 I2D: score=1 STRING: ENSP00000314949
    PSMD3O432422, 3, ENSP000002646394MINT-7945693 I2D: score=1 STRING: ENSP00000264639
    DYNC1H1Q142042, 3, ENSP000003489654MINT-7945693 I2D: score=1 STRING: ENSP00000348965
    SEPT7Q161812, 3, ENSP000003819924MINT-7945693 I2D: score=1 STRING: ENSP00000381992
    CABLES1Q8TDN43, ENSP000002569254I2D: score=3 STRING: ENSP00000256925
    CABLES2Q9BTV73, ENSP000002791014I2D: score=3 STRING: ENSP00000279101
    ACTR8Q9H9813, ENSP000003368424I2D: score=2 STRING: ENSP00000336842
    CCNA2P202483, ENSP000002740264I2D: score=2 STRING: ENSP00000274026
    CCNCP248633, ENSP000003582224I2D: score=2 STRING: ENSP00000358222
    CDKN1AP389363, ENSP000002447414I2D: score=2 STRING: ENSP00000244741
    CDKN1BP465273, ENSP000002288724I2D: score=2 STRING: ENSP00000228872
    E2F1Q010943, ENSP000003455714I2D: score=2 STRING: ENSP00000345571
    KPNA6O606843, ENSP000003627284I2D: score=2 STRING: ENSP00000362728
    ANAPC10Q9UM133, ENSP000003100714I2D: score=1 STRING: ENSP00000310071
    ARL1P406163, ENSP000002616364I2D: score=1 STRING: ENSP00000261636
    CAMKK2Q96RR43, ENSP000003127414I2D: score=1 STRING: ENSP00000312741
    CDC34P494273, ENSP000002155744I2D: score=1 STRING: ENSP00000215574
    CDC37Q165433, ENSP000002220054I2D: score=1 STRING: ENSP00000222005
    EIF2AK2P195253, ENSP000002330574I2D: score=1 STRING: ENSP00000233057
    GNB2L1P632443, ENSP000003660134I2D: score=1 STRING: ENSP00000366013
    ICKQ9UPZ93, ENSP000002630434I2D: score=1 STRING: ENSP00000263043
    KIR3DL1P436293, ENSP000003756084I2D: score=1 STRING: ENSP00000375608
    MAPK1P284823, ENSP000002158324I2D: score=1 STRING: ENSP00000215832
    MOB1AQ9H8S93, ENSP000003793644I2D: score=1 STRING: ENSP00000379364
    POLE2P562823, ENSP000002163674I2D: score=1 STRING: ENSP00000216367
    PSMB2P497213, ENSP000003623344I2D: score=1 STRING: ENSP00000362334
    RAD51Q066093, ENSP000002678684I2D: score=1 STRING: ENSP00000267868
    TFDP1Q141863, ENSP000003645194I2D: score=1 STRING: ENSP00000364519
    TOP3AQ134723, ENSP000003216364I2D: score=1 STRING: ENSP00000321636
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CCNE1P248643, ENSP000002626434I2D: score=2 STRING: ENSP00000262643
    CCNE2O960203, ENSP000003091814I2D: score=2 STRING: ENSP00000309181
    E2F2Q142093, ENSP000003552494I2D: score=1 STRING: ENSP00000355249
    E2F3O007163, ENSP000002629044I2D: score=2 STRING: ENSP00000262904
    MAD2L1Q132573, ENSP000002965094I2D: score=1 STRING: ENSP00000296509
    TTKP339812, ENSP000002305104MINT-7945693 STRING: ENSP00000230510
    CHEK1O147572, ENSP000002789164MINT-7945693 STRING: ENSP00000278916
    DDX6P261963, ENSP000002640184I2D: score=1 STRING: ENSP00000264018
    DDX3XO005712, ENSP000003828404MINT-7945693 STRING: ENSP00000382840
    CDC14AQ9UNH53, ENSP000003549164I2D: score=1 STRING: ENSP00000354916
    PPP6CO007433, ENSP000003921474I2D: score=1 STRING: ENSP00000392147
    GTF2BQ004033, ENSP000003595314I2D: score=1 STRING: ENSP00000359531
    PSMD8P485563, ENSP000002150714I2D: score=2 STRING: ENSP00000215071
    RAD21O602162, ENSP000002973384MINT-7945693 STRING: ENSP00000297338
    TAF12Q165142, ENSP000002639744MINT-7945693 STRING: ENSP00000263974
    LPIN3Q9BQK83, ENSP000003623544I2D: score=1 STRING: ENSP00000362354
    ATP6V1B2P212813, ENSP000002763904I2D: score=1 STRING: ENSP00000276390
    KIFC3Q9BVG83, ENSP000003689764I2D: score=1 STRING: ENSP00000368976
    PUF60Q9UHX12, ENSP000003220164MINT-7945693 STRING: ENSP00000322016
    ASF1AQ9Y2943, ENSP000002295954I2D: score=1 STRING: ENSP00000229595
    PAK3O759143, ENSP000003538644I2D: score=2 STRING: ENSP00000353864
    PAK4O960132, ENSP000003510494MINT-7945693 STRING: ENSP00000351049
    SSU72Q9NP773, ENSP000002913864I2D: score=1 STRING: ENSP00000291386
    MAP2K3P467342, ENSP000003450834MINT-7945693 STRING: ENSP00000345083
    KPNA1P522942, ENSP000003437014MINT-7945693 STRING: ENSP00000343701
    CDK12Q9NYV42, ENSP000003988804MINT-7945693 STRING: ENSP00000398880
    HSP90AA1P079002, ENSP000003351534MINT-7945693 STRING: ENSP00000335153
    HSP90B1P146252, ENSP000002997674MINT-7945693 STRING: ENSP00000299767
    CKAP5Q140082, ENSP000003465664MINT-7945693 STRING: ENSP00000346566
    DNA2P515303, ENSP000003821334I2D: score=1 STRING: ENSP00000382133
    SETXQ7Z3332, ENSP000002241404MINT-7945693 STRING: ENSP00000224140
    GYS1P138073, ENSP000003179044I2D: score=4 STRING: ENSP00000317904
    CDK9P507502, ENSP000003623614MINT-7945693 STRING: ENSP00000362361
    BUB3O436842, ENSP000003578584MINT-7945693 STRING: ENSP00000357858
    EIF3IQ133472, ENSP000003626884MINT-7945693 STRING: ENSP00000362688
    EXOC1Q9NV702, ENSP000003265144MINT-7945693 STRING: ENSP00000326514
    EXOC3O606452, ENSP000003233774MINT-7945693 STRING: ENSP00000323377
    HSP90AB1P082382, ENSP000003258754MINT-7945693 STRING: ENSP00000325875
    KPNA2P522922, ENSP000003324554MINT-7945693 STRING: ENSP00000332455
    NUP153P497902, ENSP000002620774MINT-7945693 STRING: ENSP00000262077
    PAK1Q131532, ENSP000002785684MINT-7945693 STRING: ENSP00000278568
    PBRM1Q86U862, ENSP000003492134MINT-7945693 STRING: ENSP00000349213
    PUM2Q8TB722, ENSP000003381734MINT-7945693 STRING: ENSP00000338173
    SMARCA2P515312, ENSP000002657734MINT-7945693 STRING: ENSP00000265773
    SMARCB1Q128242, ENSP000002631214MINT-7945693 STRING: ENSP00000263121
    SMN1Q166372, ENSP000003700834MINT-7945693 STRING: ENSP00000370083
    SMN2Q166372, ENSP000003701194MINT-7945693 STRING: ENSP00000370119
    SNW1Q135732, ENSP000002615314MINT-7945693 STRING: ENSP00000261531
    CCNB2O950673I2D: score=8 
    CDC6Q997413I2D: score=4 
    CLUHO751533I2D: score=4 
    FZR1Q9UM113I2D: score=4 
    HSPA9P386463I2D: score=3 
    CBSP355203I2D: score=2 
    CDC7O003113I2D: score=2 
    EEF2P136393I2D: score=2 
    SIN3AQ96ST33I2D: score=2 
    ACTR5Q9H9F93I2D: score=1 
    ARFGAP1Q8N6T33I2D: score=1 
    ARRB2P321213I2D: score=1 
    ASS1P009663I2D: score=1 
    ATAD2Q6PL183I2D: score=1 
    ATP5C1P365423I2D: score=1 
    AURKCQ9UQB93I2D: score=1 
    BUD31P412233I2D: score=1 
    CADP277083I2D: score=1 
    CCBL1Q167733I2D: score=1 
    CDK7P506133I2D: score=1 
    DDX11L8A8MPP13I2D: score=1 
    DDX27Q96GQ73I2D: score=1 
    DUS3LQ96G463I2D: score=1 
    EIF2AQ9BY443I2D: score=1 
    EIF2B1Q142323I2D: score=1 
    EIF2B2P497703I2D: score=1 
    EIF2B4Q9UI103I2D: score=1 
    EIF5AP632413I2D: score=1 
    EPS15L1Q9UBC23I2D: score=1 
    GFPT2O948083I2D: score=1 
    GMPPBQ9Y5P63I2D: score=1 
    GOT1P171743I2D: score=1 
    HIST1H2BHQ930793I2D: score=1 
    HIST2H2BFQ5QNW63I2D: score=1 
    ING3Q9NXR83I2D: score=1 
    IP6K3Q96PC23I2D: score=1 
    IPO4Q8TEX93I2D: score=1 
    KIF3BO150663I2D: score=1 
    LDHDQ86WU23I2D: score=1 
    LIASO437663I2D: score=1 
    MARCH6O603373I2D: score=1 
    MAT1AQ002663I2D: score=1 
    MCM3P252053I2D: score=1 
    MON1AQ86VX93I2D: score=1 
    MYO1EQ129653I2D: score=1 
    NAA20P615993I2D: score=1 
    NAP1L4Q997333I2D: score=1 
    NSUN2Q08J233I2D: score=1 
    ODC1P119263I2D: score=1 
    PAN2Q504Q33I2D: score=1 
    PAN3Q58A453I2D: score=1 
    PCNAP120043I2D: score=1 
    PFDN5Q994713I2D: score=1 
    PFKLP178583I2D: score=1 
    PIKFYVEQ9Y2I73I2D: score=1 
    PLAAQ9Y2633I2D: score=1 
    POLA1P098843I2D: score=1 
    PPATQ062033I2D: score=1 
    PPP2R2DQ66LE63I2D: score=1 
    PPP3R1P630983I2D: score=1 
    PRKCEQ021563I2D: score=1 
    PSMD14O004873I2D: score=1 
    PSMD4P550363I2D: score=1 
    PYGLP067373I2D: score=1 
    RCC1P187543I2D: score=1 
    RPA1P276943I2D: score=1 
    RPL36AP838813I2D: score=1 
    RPS5P467823I2D: score=1 
    RPSAP088653I2D: score=1 
    RRM2P313503I2D: score=1 
    RSL24D1Q9UHA33I2D: score=1 
    SRMP196233I2D: score=1 
    STIP1P319483I2D: score=1 
    STK38LQ9Y2H13I2D: score=1 
    SUPT3HO754863I2D: score=1 
    TADA2AO754783I2D: score=1 
    TCEA1P231933I2D: score=1 
    TOP1P113873I2D: score=1 
    UBE2AP494593I2D: score=1 
    UBE4BO951553I2D: score=1 
    USP4Q131073I2D: score=1 
    USP7Q930093I2D: score=1 
    VAC14Q08AM63I2D: score=1 
    XPO5Q9HAV43I2D: score=1 
    YEATS4O956193I2D: score=1 
    ABCF1Q8NE712MINT-7945693
    ABCF3Q9NUQ82MINT-7945693
    ACIN1Q9UKV32MINT-7945693
    ACTBP607092MINT-7945693
    ACTL6AO960192MINT-7945693
    ACTR1AP611632MINT-7945693
    ACTR2P611602MINT-7945693
    ADNPQ9H2P02MINT-7945693
    AHNAKQ096662MINT-7945693
    ANAPC1Q9H1A42MINT-7945693
    ANLNQ9NQW62MINT-7945693
    AP1B1Q105672MINT-7945693
    AP3B1O002032MINT-7945693
    APBB1IPQ7Z5R62MINT-7945693
    API5Q9BZZ52MINT-7945693
    AQRO603062MINT-7945693
    ARAP1Q96P482MINT-7945693
    ARCN1P484442MINT-7945693
    ARF4P180852MINT-7945693
    ARF5P840852MINT-7945693
    ARFGEF2Q9Y6D52MINT-7945693
    ARHGEF1Q928882MINT-7945693
    ARHGEF2Q929742MINT-7945693
    ARID1AO144972MINT-7945693
    ASUNQ9NVM92MINT-7945693
    ATMQ133152MINT-7945693
    ATRXP461002MINT-7945693
    AURKAO149652MINT-7945693
    AURKBQ96GD42MINT-7945693
    BABAM1Q9NWV82MINT-7945693
    BAZ1AQ9NRL22MINT-7945693
    BCAS2O759342MINT-7945693
    BCL7CQ8WUZ02MINT-7945693
    BCLAF1Q9NYF82MINT-7945693
    BLMP541322MINT-7945693
    BRD8Q9H0E92MINT-7945693
    BRIX1Q8TDN62MINT-7945693
    BTAF1O149812MINT-7945693
    BUB1BO605662MINT-7945693
    BZW1Q7L1Q62MINT-7945693
    BZW2Q9Y6E22MINT-7945693
    C7orf55-LUC7L2Q9Y3832MINT-7945693
    CAND1Q86VP62MINT-7945693
    CAPGP401212MINT-7945693
    CAPZA1P529072MINT-7945693
    CCNB1P146352MINT-7945693
    CCNT1O605632MINT-7945693
    CCT4P509912MINT-7945693
    CCT5P486432MINT-7945693
    CCT6AP402272MINT-7945693
    CCT8P509902MINT-7945693
    CDC5LQ994592MINT-7945693
    CDC73Q6P1J92MINT-7945693
    CDK1P064932MINT-7945693
    CDKN2AIPQ9NXV62MINT-7945693
    CHD1LQ86WJ12MINT-7945693
    CHD3Q128732MINT-7945693
    CHD4Q148392MINT-7945693
    CHD7Q9P2D12MINT-7945693
    CHD8Q9HCK82MINT-7945693
    CLP1Q929892MINT-7945693
    COPAP536212MINT-7945693
    COPB1P536182MINT-7945693
    COPB2P356062MINT-7945693
    COPG1Q9Y6782MINT-7945693
    COPG2Q9UBF22MINT-7945693
    COPS3Q9UNS22MINT-7945693
    COPS5Q929052MINT-7945693
    COPS6Q7L5N12MINT-7945693
    CPNE3O751312MINT-7945693
    CPSF1Q105702MINT-7945693
    CPSF2Q9P2I02MINT-7945693
    CPSF3Q9UKF62MINT-7945693
    CPSF4O956392MINT-7945693
    CPSF7Q8N6842MINT-7945693
    CSE1LP550602MINT-7945693
    CSKP412402MINT-7945693
    CSTF3Q129962MINT-7945693
    CTTNQ142472MINT-7945693
    CUL1Q136162MINT-7945693
    DCTN1Q142032MINT-7945693
    DCTN2Q135612MINT-7945693
    DDX1Q924992MINT-7945693
    DDX17Q928412MINT-7945693
    DDX19BQ9UMR22MINT-7945693
    DDX21Q9NR302MINT-7945693
    DDX23Q9BUQ82MINT-7945693
    DDX39AO001482MINT-7945693
    DDX39BQ138382MINT-7945693
    DDX41Q9UJV92MINT-7945693
    DDX42Q86XP32MINT-7945693
    DDX46Q7L0142MINT-7945693
    DDX5P178442MINT-7945693
    DEPDC7Q96QD52MINT-7945693
    DFNA5O604432MINT-7945693
    DHX8Q145622MINT-7945693
    DHX9Q082112MINT-7945693
    DIAPH3Q9NSV42MINT-7945693
    DIDO1Q9BTC02MINT-7945693
    DMAP1Q9NPF52MINT-7945693
    DNAJC13O751652MINT-7945693
    DNM1LO004292MINT-7945693
    DNM2P505702MINT-7945693
    DOCK1Q141852MINT-7945693
    DOCK2Q926082MINT-7945693
    DPF2Q927852MINT-7945693
    DRG1Q9Y2952MINT-7945693
    DSPP159242MINT-7945693
    DYNC1LI2O432372MINT-7945693
    EBNA1BP2Q998482MINT-7945693
    EEFSECP577722MINT-7945693
    EFTUD2Q150292MINT-7945693
    EHD1Q9H4M92MINT-7945693
    EHD4Q9H2232MINT-7945693
    EIF2S3P410912MINT-7945693
    EIF3EP602282MINT-7945693
    EIF3GO758212MINT-7945693
    EIF3HO153722MINT-7945693
    EIF3LQ9Y2622MINT-7945693
    EIF4A1P608422MINT-7945693
    EIF4A3P389192MINT-7945693
    EIF4G2P783442MINT-7945693
    EIF5BO608412MINT-7945693
    ELAVL1Q157172MINT-7945693
    ENAHQ8N8S72MINT-7945693
    ENSG00000096150P622692MINT-7945693
    ENSG00000183311P074372MINT-7945693
    ENSG00000206287Q065872MINT-7945693
    ENSG00000206490Q8NE712MINT-7945693
    ENSG00000215425Q138382MINT-7945693
    ENSG00000223367P622692MINT-7945693
    ENSG00000224156P074372MINT-7945693
    ENSG00000225073Q138382MINT-7945693
    ENSG00000225859Q138382MINT-7945693
    ENSG00000225989Q8NE712MINT-7945693
    ENSG00000226225P622692MINT-7945693
    ENSG00000226788Q065872MINT-7945693
    ENSG00000227739P074372MINT-7945693
    ENSG00000228520Q065872MINT-7945693
    ENSG00000229496Q138382MINT-7945693
    ENSG00000229684P074372MINT-7945693
    ENSG00000230624Q138382MINT-7945693
    ENSG00000231115Q065872MINT-7945693
    ENSG00000231129Q8NE712MINT-7945693
    ENSG00000232169Q8NE712MINT-7945693
    ENSG00000232421P074372MINT-7945693
    ENSG00000232575P074372MINT-7945693
    ENSG00000235067P074372MINT-7945693
    ENSG00000235107Q065872MINT-7945693
    ENSG00000235439Q138382MINT-7945693
    ENSG00000235650P622692MINT-7945693
    ENSG00000236149Q8NE712MINT-7945693
    ENSG00000236342Q8NE712MINT-7945693
    EPPK1P581072MINT-7945693
    EPS8L2Q9H6S32MINT-7945693
    ETF1P624952MINT-7945693
    ETV6P412122MINT-7945693
    EXOC2Q96KP12MINT-7945693
    EXOC4Q96A652MINT-7945693
    EXOC5O004712MINT-7945693
    EXOC7Q9UPT52MINT-7945693
    EXOSC6Q5RKV62MINT-7945693
    FAM129BQ96TA12MINT-7945693
    FANCIQ9NVI12MINT-7945693
    FASNP493272MINT-7945693
    FERMT1Q9BQL62MINT-7945693
    FHOD1Q9Y6132MINT-7945693
    FIP1L1Q6UN152MINT-7945693
    FUBP1Q96AE42MINT-7945693
    FUSP356372MINT-7945693
    FYTTD1Q96QD92MINT-7945693
    G3BP2Q9UN862MINT-7945693
    GATAD2AQ86YP42MINT-7945693
    GATAD2BQ8WXI92MINT-7945693
    GEMIN4P576782MINT-7945693
    GNA14O958372MINT-7945693
    GSPT1P151702MINT-7945693
    GTF2IP783472MINT-7945693
    GTF3C1Q127892MINT-7945693
    GTF3C2Q8WUA42MINT-7945693
    GTF3C3Q9Y5Q92MINT-7945693
    GTF3C4Q9UKN82MINT-7945693
    GTPBP4Q9BZE42MINT-7945693
    GULP1Q9UBP92MINT-7945693
    HBS1LQ9Y4502MINT-7945693
    HDAC1Q135472MINT-7945693
    HDAC2Q927692MINT-7945693
    HDLBPQ003412MINT-7945693
    HELLSQ9NRZ92MINT-7945693
    HIP1RO751462MINT-7945693
    HIRAP541982MINT-7945693
    HNRNPA0Q131512MINT-7945693
    HNRNPA1P096512MINT-7945693
    HNRNPA2B1P226262MINT-7945693
    HNRNPA3P519912MINT-7945693
    HNRNPABQ997292MINT-7945693
    HNRNPCP079102MINT-7945693
    HNRNPDQ141032MINT-7945693
    HNRNPFP525972MINT-7945693
    HNRNPH1P319432MINT-7945693
    HNRNPKP619782MINT-7945693
    HNRNPMP522722MINT-7945693
    HNRNPRO433902MINT-7945693
    HNRNPUQ008392MINT-7945693
    HSPA12AO433012MINT-7945693
    HSPA5P110212MINT-7945693
    HSPA8P111422MINT-7945693
    HSPB1P047922MINT-7945693
    HTATSF1O437192MINT-7945693
    IKQ131232MINT-7945693
    ILF2Q129052MINT-7945693
    ILF3Q129062MINT-7945693
    ILKQ134182MINT-7945693
    INTS1Q8N2012MINT-7945693
    INTS12Q96CB82MINT-7945693
    INTS3Q68E012MINT-7945693
    IPO5O004102MINT-7945693
    IPO9Q96P702MINT-7945693
    IQGAP1P469402MINT-7945693
    KDM1AO603412MINT-7945693
    KHDRBS1Q076662MINT-7945693
    KIAA1279Q96EK52MINT-7945693
    KIF21AQ7Z4S62MINT-7945693
    KIF27Q86VH22MINT-7945693
    KIF2CQ996612MINT-7945693
    KIF4AO952392MINT-7945693
    KMT2DO146862MINT-7945693
    KPNB1Q149742MINT-7945693
    KTI12Q96EK92MINT-7945693
    LDLRAP1Q5SW962MINT-7945693
    LIMS1P480592MINT-7945693
    LMNAP025452MINT-7945693
    LRRC40Q9H9A62MINT-7945693
    LRRC47Q8N1G42MINT-7945693
    LRWD1Q9UFC02MINT-7945693
    LUC7L2Q9Y3832MINT-7945693
    MAD1L1Q9Y6D92MINT-7945693
    MAGED2Q9UNF12MINT-7945693
    MAP2K2P365072MINT-7945693
    MAP2K7O147332MINT-7945693
    MATR3P432432MINT-7945693
    MBD3O959832MINT-7945693
    MDN1Q9NU222MINT-7945693
    MED4Q9NPJ62MINT-7945693
    METTL13Q8N6R02MINT-7945693
    MLKLQ8NB162MINT-7945693
    MORF4L1Q9UBU82MINT-7945693
    MORF4L2Q150142MINT-7945693
    MTA2O947762MINT-7945693
    MVPQ147642MINT-7945693
    MYH9P355792MINT-7945693
    MYO15BQ96JP22MINT-7945693
    NACC1Q96RE72MINT-7945693
    NBNO609342MINT-7945693
    NCAPGQ9BPX32MINT-7945693
    NCAPHQ150032MINT-7945693
    NCLP193382MINT-7945693
    NCOR1O753762MINT-7945693
    NCOR2Q9Y6182MINT-7945693
    NDC80O147772MINT-7945693
    NELFBQ8WX922MINT-7945693
    NELFCDQ8IXH72MINT-7945693
    NFICP086512MINT-7945693
    NIPBLQ6KC792MINT-7945693
    NOLC1Q149782MINT-7945693
    NONOQ152332MINT-7945693
    NR2C2P491162MINT-7945693
    NR2F2P244682MINT-7945693
    NR2F6P105882MINT-7945693
    NSFP464592MINT-7945693
    NSUN5Q96P112MINT-7945693
    NUDCQ9Y2662MINT-7945693
    NUF2Q9BZD42MINT-7945693
    NUP155O756942MINT-7945693
    NUP37Q8NFH42MINT-7945693
    OLA1Q9NTK52MINT-7945693
    ORC2Q134162MINT-7945693
    ORC3Q9UBD52MINT-7945693
    OTULINQ96BN82MINT-7945693
    OXSR1O957472MINT-7945693
    PABPC1P119402MINT-7945693
    PABPN1Q86U422MINT-7945693
    PARP4Q9UKK32MINT-7945693
    PARVAQ9NVD72MINT-7945693
    PARVBQ9HBI12MINT-7945693
    PAXIP1Q6ZW492MINT-7945693
    PCBP2Q153662MINT-7945693
    PCF11O949132MINT-7945693
    PDCD6IPQ8WUM42MINT-7945693
    PDLIM7Q9NR122MINT-7945693
    PELP1Q8IZL82MINT-7945693
    PFKMP082372MINT-7945693
    PFKPQ018132MINT-7945693
    PHGDHO431752MINT-7945693
    PICALMQ134922MINT-7945693
    PIK3R4Q995702MINT-7945693
    PKN2Q165132MINT-7945693
    PKP3Q9Y4462MINT-7945693
    PLECQ151492MINT-7945693
    PLRG1O436602MINT-7945693
    PNNQ9H3072MINT-7945693
    POGZQ7Z3K32MINT-7945693
    POLD1P283402MINT-7945693
    POLEQ078642MINT-7945693
    POLR1CO151602MINT-7945693
    POLR2EP193882MINT-7945693
    PPP1CAP621362MINT-7945693
    PPP2R1AP301532MINT-7945693
    PPP2R1BP301542MINT-7945693
    PRKAG1P546192MINT-7945693
    PRKDCP785272MINT-7945693
    PRPF19Q9UMS42MINT-7945693
    PRPF40AO754002MINT-7945693
    PRPF6O949062MINT-7945693
    PRPF8Q6P2Q92MINT-7945693
    PSMC1P621912MINT-7945693
    PSMC3P179802MINT-7945693
    PSMC4P436862MINT-7945693
    PSMC6P623332MINT-7945693
    PSMD11O002312MINT-7945693
    PSMD12O002322MINT-7945693
    PSMD13Q9UNM62MINT-7945693
    PTBP1P265992MINT-7945693
    PURAQ005772MINT-7945693
    PWP1Q136102MINT-7945693
    RACGAP1Q9H0H52MINT-7945693
    RAD18Q9NS912MINT-7945693
    RAD50Q928782MINT-7945693
    RAE1P784062MINT-7945693
    RALYQ9UKM92MINT-7945693
    RANBP2P497922MINT-7945693
    RANGAP1P460602MINT-7945693
    RBBP7Q165762MINT-7945693
    RBM10P981752MINT-7945693
    RBM14Q96PK62MINT-7945693
    RBM15Q96T372MINT-7945693
    RBM17Q96I252MINT-7945693
    RBM39Q144982MINT-7945693
    RBM4Q9BWF32MINT-7945693
    RBM45Q8IUH32MINT-7945693
    RBMXP381592MINT-7945693
    RCOR1Q9UKL02MINT-7945693
    RFC2P352502MINT-7945693
    RFC4P352492MINT-7945693
    RFC5P409372MINT-7945693
    RIF1Q5UIP02MINT-7945693
    RING1Q065872MINT-7945693
    RIOK1Q9BRS22MINT-7945693
    RNF2Q994962MINT-7945693
    ROCK2O751162MINT-7945693
    RPL12P300502MINT-7945693
    RPL13P263732MINT-7945693
    RPL19P840982MINT-7945693
    RPL22P352682MINT-7945693
    RPL23AP627502MINT-7945693
    RPL3P390232MINT-7945693
    RPL31P628992MINT-7945693
    RPL36Q9Y3U82MINT-7945693
    RPL7AP624242MINT-7945693
    RPL8P629172MINT-7945693
    RPS14P622632MINT-7945693
    RPS18P622692MINT-7945693
    RPS19P390192MINT-7945693
    RPS25P628512MINT-7945693
    RPS6KA4O756762MINT-7945693
    RPS6KB2Q9UBS02MINT-7945693
    RTCBQ9Y3I02MINT-7945693
    RUVBL2Q9Y2302MINT-7945693
    SART1O432902MINT-7945693
    SCYL2Q6P3W72MINT-7945693
    SEC23BQ154372MINT-7945693
    SEC31BQ9NQW12MINT-7945693
    SEH1LQ96EE32MINT-7945693
    SEPT9Q9UHD82MINT-7945693
    SF3A1Q154592MINT-7945693
    SF3A3Q128742MINT-7945693
    SF3B1O755332MINT-7945693
    SF3B2Q134352MINT-7945693
    SF3B3Q153932MINT-7945693
    SF3B4Q154272MINT-7945693
    SF3B6Q9Y3B42MINT-7945693
    SFPQP232462MINT-7945693
    SHOC2Q9UQ132MINT-7945693
    SHROOM3Q8TF722MINT-7945693
    SMARCA5O602642MINT-7945693
    SMARCAD1Q9H4L72MINT-7945693
    SMARCC1Q929222MINT-7945693
    SMARCC2Q8TAQ22MINT-7945693
    SMARCD1Q96GM52MINT-7945693
    SMARCE1Q969G32MINT-7945693
    SMC1AQ146832MINT-7945693
    SMC2O953472MINT-7945693
    SMC3Q9UQE72MINT-7945693
    SMCHD1A6NHR92MINT-7945693
    SND1Q7KZF42MINT-7945693
    SNRNP200O756432MINT-7945693
    SNRNP40Q96DI72MINT-7945693
    SNRNP70P086212MINT-7945693
    SNRPB2P085792MINT-7945693
    SNRPD3P623182MINT-7945693
    SNUPNO951492MINT-7945693
    SPATA5Q8NB902MINT-7945693
    SPATA5L1Q9BVQ72MINT-7945693
    SPTAN1Q138132MINT-7945693
    SPTBN1Q010822MINT-7945693
    SQSTM1Q135012MINT-7945693
    SRP19P091322MINT-7945693
    SRP54P610112MINT-7945693
    SRP68Q9UHB92MINT-7945693
    SRP72O760942MINT-7945693
    SRRM1Q8IYB32MINT-7945693
    SRRM2Q9UQ352MINT-7945693
    SRSF1Q079552MINT-7945693
    SRSF11Q055192MINT-7945693
    SRSF2Q011302MINT-7945693
    SRSF3P841032MINT-7945693
    SRSF5Q132432MINT-7945693
    SRSF6Q132472MINT-7945693
    SRSF7Q166292MINT-7945693
    STAG1Q8WVM72MINT-7945693
    SUGT1Q9Y2Z02MINT-7945693
    SUPV3L1Q8IYB82MINT-7945693
    SYMPKQ927972MINT-7945693
    SYNCRIPO605062MINT-7945693
    TAF9Q165942MINT-7945693
    TAOK1Q7L7X32MINT-7945693
    TARDBPQ131482MINT-7945693
    TBL1XR1Q9BZK72MINT-7945693
    THOC1Q96FV92MINT-7945693
    THOC2Q8NI272MINT-7945693
    THRAP3Q9Y2W12MINT-7945693
    TIAL1Q010852MINT-7945693
    TLN1Q9Y4902MINT-7945693
    TMPOP421662MINT-7945693
    TOX4O948422MINT-7945693
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS8846921
    GO:0006468protein phosphorylation ----
    GO:0007067mitosis IEA--
    GO:0008283cell proliferation TAS18794154
    GO:0045023G0 to G1 transition TAS15084261

    Find genes that share ontologies with CDK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    2 HMDB Compounds for CDK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDK3 gene: 
    NM_001258.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588812 ENST00000425876 ENST00000586261 ENST00000448471
    miRNA
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    Selected AceView cDNA sequences (see all 138):

    AI565655 BM706946 BU785194 CD671351 AI131108 CR604264 BC047782 BM053101 
    BM053162 CK904002 AU120188 CF128049 BM907267 BQ189457 BM671003 BQ962463 
    BI858083 BU728264 BQ109222 BG287063 BU784937 BG394244 AI885421 BQ674947 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGAGGGGT
    CDK3 Expression
    About this image

    CDK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK3 Protein Expression

    UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526
    Tissue specificity: Expressed in cancer cell lines and glioblastoma tissue

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk3-ps5 cyclin-dependent kinase 3, pseudogene   --   11 (81.02 cM) 116216003 
    chicken
    (Gallus gallus)
    Aves CDK31 cyclin-dependent kinase 3 75.67(n)
    81.33(a)
      429642  NM_001081706.2  NP_001075175.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDK36
    cyclin-dependent kinase 3
    75(a)
    1 ↔ 1
    2(113303478-113320825)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-57f11.16
    si:dkeyp-57f11.1
    38(a)
    many ↔ many
    3(39170642-39174830) ENSDARG00000030163
    fruit fly
    (Drosophila melanogaster)
    Insecta cdc23 G2/M transition of mitotic cell cycle
    protein more
    65(a)
    (best of 4)
      31D11   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC286
    Catalytic subunit of the main cell cycle cyclin-de...
    62(a)
    1 → many
    II(560078-560974) YBR160W
    soybean
    (Glycine max)
    eudicotyledons Gma.131182 Glycine max cv Prize protein kinase mRNA. 74.36(n)    M93140.1 
    wheat
    (Triticum aestivum)
    Liliopsida Ta.66752 Triticum aestivum p34cdc2 (cdc2TaB) mRNA, partial cds 78.66(n)    U23410.1 


    ENSEMBL Gene Tree for CDK3 (if available)
    TreeFam Gene Tree for CDK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CDK3 gene
    CDK62  CDK22  CDK42  CDK12  
    Selected SIMAP similar genes for CDK3 using alignment to 3 protein entries:     CDK3_HUMAN (see all proteins) (see all similar genes):
    CDK1    CDC2    CDK5    DKFZp686L20222    CDK18    CDK2
    PCTK1    PHKG2    CDK17    CDK16    STK3    PCTK3
    CDK14    CDK15    CDC2L2    CDK7    CDK6    CDC2L1

    Find genes that share paralogs with CDK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    5 SNPs for CDK3    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419734
    A glioblastoma multiforme sample4--see VAR_0419732 S N mis40--------
    rs349184461,2,4
    ----see VAR_0419742 mis40--------
    rs178842511,2,4
    ----see VAR_0211022 mis40--------
    rs20695321,2,4
    ----see VAR_0211012 mis40--------
    rs346702671,2,4
    ----see VAR_0419752 mis40--------

    HapMap Linkage Disequilibrium report for CDK3 (73996987 - 74002080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CDK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908826CNV Loss21882294
    nsv833546CNV Loss17160897
    nsv908825CNV Loss21882294
    nsv908824CNV Loss21882294
    dgv3270n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 123828    OMIM disorders: --


    Find genes that share disorders with CDK3           About GenesLikeMe

    2 Novoseek inferred disease relationships for CDK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 7882308 (2)
    cancer 0 2 18794154 (1), 7882308 (1)


    Export disorders for CDK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK3 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with CDK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3, 9 Meyerson M.... Tsai L.-H. (EMBO J. 1992)
    2. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. (PubMed id 18794154)1, 2, 9 Zheng D....Dong Z. (Cancer Res. 2008)
    3. Cyclin C/cdk3 promotes Rb-dependent G0 exit. (PubMed id 15084261)1, 2 Ren S. and Rollins B.J. (Cell 2004)
    4. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. (PubMed id 8846921)1, 2 Hofmann F. and Livingston D.M. (Genes Dev. 1996)
    5. Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. (PubMed id 9811456)1, 9 Braun K....HengstschlAoger M. (Oncogene 1998)
    6. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PubMed id 11733001)1, 9 Yamochi T....Matsuoka M. (Eur. J. Biochem. 2001)
    7. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. (PubMed id 7882308)1, 9 Bullrich F....Croce C.M. (Cancer Res. 1995)
    8. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. (PubMed id 9190208)1, 9 Connell-Crowley L....Goodrich D.W. (Mol. Biol. Cell 1997)
    9. Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells. (PubMed id 8626531)1, 9 Sasaguri T....Ogata J. (J. Biol. Chem. 1996)
    10. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. (PubMed id 8242750)1, 9 Gyuris J.... Brent R. (Cell 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1018 HGNC: 1772 AceView: CDK3 Ensembl:ENSG00000250506 euGenes: HUgn1018
    ECgene: CDK3 H-InvDB: CDK3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDK3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDK3 gene:
    Search GeneIP for patents involving CDK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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