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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK3 Gene

protein-coding   GIFtS: 57
GCID: GC17P073996

Cyclin-Dependent Kinase 3

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 31 2
Cell Division Protein Kinase 32 3
EC 2.7.11.223 8
CDKN33
EC 2.7.118

External Ids:    HGNC: 17721   Entrez Gene: 10182   Ensembl: ENSG000002505067   OMIM: 1238285   UniProtKB: Q005263   

Export aliases for CDK3 gene to outside databases

Previous GC identifers: GC17M073921 GC17P077001 GC17P074439 GC17P074572 GC17P074594 GC17P071486 GC17P073977 GC17P069422


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK3 Gene:
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase,
in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin
C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDK3 Gene: 
CDK3 (cyclin-dependent kinase 3) is a protein-coding gene. Diseases associated with CDK3 include retinoblastoma, and herpes simplex. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526
Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle;
involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates
histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional
activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is
required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2
and E2F3 in a RB1-independent manner

Gene Wiki entry for CDK3 (Cyclin-dependent kinase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK3 gene promoter:
         HOXA9   HOXA9B   AML1a   Pax-5   RelA   AP-4   CUTL1   Meis-1b   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

CDK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P073996:  view genomic region     (about GC identifiers)

Start:
73,996,987 bp from pter      End:
74,002,080 bp from pter
Size:
5,094 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 3  
Size: 305 amino acids; 35046 Da
Subunit: Interacts with CABLES1 and CABLES2 (By similarity). Interacts with ATF1. Binding to CCNC/cyclin-C
promotes RB1 phosphorylation
1 PDB 3D structure from and Proteopedia for CDK3:
1LFN (3D)    

Explore the universe of human proteins at neXtProt for CDK3: NX_Q00526

Explore proteomics data for CDK3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q00526

  • 4/17 DME Specific Peptides for CDK3 (Q00526) (see all 17)
     VIHRDLK  VVTLWYR  DFGLARA  EGVPSTA 

    CDK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK3 Protein Expression
    REFSEQ proteins: NP_001249.1  
    ENSEMBL proteins: 
     ENSP00000466237   ENSP00000410561   ENSP00000465062   ENSP00000400088  

    Human Recombinant Protein Products for CDK3: 
    EMD Millipore Purified and/or Recombinant CDK3 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CDK3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CDK3
    GenScript Custom Purified and Recombinant Proteins Services for CDK3
    Novus Biologicals CDK3 Proteins
    Novus Biologicals CDK3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK3 


    CDK3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CDK3
    OriGene Custom Antibody Services for CDK3
    GenScript Custom Superior Antibodies Services for CDK3
    Novus Biologicals CDK3 Antibodies
    Abcam antibodies for CDK3
    Cloud-Clone Corp. Antibodies for CDK3 
    ThermoFisher Antibodies for CDK3
    LSBio Antibodies in human, mouse, rat for CDK3 

    Assay Products for CDK3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK3 
    Cloud-Clone Corp. CLIAs for CDK3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 3 
    CDK1 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q00526

    ProtoNet protein and cluster: Q00526

    UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK3_HUMAN, Q00526
    Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle;
    involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates
    histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional
    activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is
    required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2
    and E2F3 in a RB1-independent manner
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for CDK3:
    cyclin dependent kinase 3,involved in cell cycle regulation (G1 to S transition),not complexing with any cyclin

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    CDK3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDK3:
     Actin fiber cells  Decreased substrate adherent c  Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK3:
    hsa-mir-146a (MIRT005705)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK3
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK3:
    hsa-miR-512-5p hsa-miR-214 hsa-miR-634 hsa-miR-1207-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidCDK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDK3
    Sirion Biotech Customized adenovirus for overexpression of CDK3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDK3 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDK3 (NM_001258)
    Sino Biological Human cDNA Clone for CDK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK3
    Sirion Biotech Customized lentivirus for stable overexpression of CDK3 
                         Customized lentivirus expression plasmids for stable overexpression of CDK3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDK3
    Search LifeMap BioReagents cell lines for CDK3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell Cycle Control of Chromosomal Replication
    Cell Cycle Control of Chromosomal Replication
    2GADD45 Pathway
    GADD45 Pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK3
        Cell Cycle Control of Chromosomal Replication
    GADD45 Pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    660/740 Interacting proteins for CDK3 (Q005262, 3 ENSP000004000884) via UniProtKB, MINT, STRING, and/or I2D (see all 740) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    HIST1H4FP628053I2D: score=3 
    HIST1H4HP628053I2D: score=3 
    HIST1H4IP628053I2D: score=3 
    HIST1H4JP628053I2D: score=3 
    HIST1H4KP628053I2D: score=3 
    HIST1H4LP628053I2D: score=3 
    HIST2H4AP628053I2D: score=3 
    HIST2H4BP628053I2D: score=3 
    HIST4H4P628053I2D: score=3 
    CDKN3Q166672, 3, ENSP000003353574MINT-17536 I2D: score=3 STRING: ENSP00000335357
    ENSG00000258947Q135092, 3MINT-7945693 I2D: score=1 
    TUBB3Q135092, 3MINT-7945693 I2D: score=1 
    PSMD2Q132002, 3MINT-7945693 I2D: score=4 
    TCP1P179872, 3MINT-7945693 I2D: score=4 
    PSMC2P359982, 3MINT-7945693 I2D: score=3 
    HSPD1P108092, 3MINT-7945693 I2D: score=2 
    ATRQ135352, 3MINT-7945693 I2D: score=1 
    BUB1O436832, 3MINT-7945693 I2D: score=1 
    CCT2P783712, 3MINT-7945693 I2D: score=1 
    CCT3P493682, 3MINT-7945693 I2D: score=1 
    CCT7Q998322, 3MINT-7945693 I2D: score=1 
    CDC16Q130422, 3MINT-7945693 I2D: score=1 
    CDC23Q9UJX22, 3MINT-7945693 I2D: score=1 
    CDC27P302602, 3MINT-7945693 I2D: score=1 
    DDX19AQ9NUU72, 3MINT-7945693 I2D: score=1 
    DIAPH1O606102, 3MINT-7945693 I2D: score=1 
    DNAJA1P316892, 3MINT-7945693 I2D: score=1 
    DYNC1H1Q142042, 3MINT-7945693 I2D: score=1 
    EEF1A1P681042, 3MINT-7945693 I2D: score=1 
    EIF2S1P051982, 3MINT-7945693 I2D: score=1 
    EIF2S2P200422, 3MINT-7945693 I2D: score=1 
    EXOSC10Q017802, 3MINT-7945693 I2D: score=1 
    FEN1P397482, 3MINT-7945693 I2D: score=1 
    GCN1L1Q926162, 3MINT-7945693 I2D: score=1 
    HLTFQ145272, 3MINT-7945693 I2D: score=1 
    KIF11P527322, 3MINT-7945693 I2D: score=1 
    MLH1P406922, 3MINT-7945693 I2D: score=1 
    MRE11AP499592, 3MINT-7945693 I2D: score=1 
    MSH2P432462, 3MINT-7945693 I2D: score=1 
    MSH6P527012, 3MINT-7945693 I2D: score=1 
    NCAPD2Q150212, 3MINT-7945693 I2D: score=1 
    PLK1P533502, 3MINT-7945693 I2D: score=1 
    PSMC5P621952, 3MINT-7945693 I2D: score=1 
    PSMD1Q994602, 3MINT-7945693 I2D: score=1 
    PSMD3O432422, 3MINT-7945693 I2D: score=1 
    RBBP5Q152912, 3MINT-7945693 I2D: score=1 
    RFC3P409382, 3MINT-7945693 I2D: score=1 
    RPL4P365782, 3MINT-7945693 I2D: score=1 
    RPLP0P053882, 3MINT-7945693 I2D: score=1 
    RPS3P233962, 3MINT-7945693 I2D: score=1 
    RUVBL1Q9Y2652, 3MINT-7945693 I2D: score=1 
    SEPT7Q161812, 3MINT-7945693 I2D: score=1 
    SMC4Q9NTJ32, 3MINT-7945693 I2D: score=1 
    TUBA4AP683662, 3MINT-7945693 I2D: score=1 
    UPF1Q929002, 3MINT-7945693 I2D: score=1 
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    POLR2AP249282, 3, ENSP000003149494MINT-7945693 I2D: score=1 STRING: ENSP00000314949
    CABLES1Q8TDN43, ENSP000002569254I2D: score=3 STRING: ENSP00000256925
    CABLES2Q9BTV73, ENSP000002791014I2D: score=3 STRING: ENSP00000279101
    CCNA2P202483, ENSP000002740264I2D: score=2 STRING: ENSP00000274026
    CCNCP248633, ENSP000003582224I2D: score=2 STRING: ENSP00000358222
    CCNE2O960203, ENSP000003091814I2D: score=2 STRING: ENSP00000309181
    CDKN1AP389363, ENSP000002447414I2D: score=2 STRING: ENSP00000244741
    CDKN1BP465273, ENSP000002288724I2D: score=2 STRING: ENSP00000228872
    E2F1Q010943, ENSP000003455714I2D: score=2 STRING: ENSP00000345571
    EIF2AK2P195253, ENSP000002330574I2D: score=1 STRING: ENSP00000233057
    KIR3DL1P436293, ENSP000003756084I2D: score=1 STRING: ENSP00000375608
    TFDP1Q141863, ENSP000003645194I2D: score=1 STRING: ENSP00000364519
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CCNE1P248643, ENSP000002626434I2D: score=2 STRING: ENSP00000262643
    CDC37Q165433, ENSP000002220054I2D: score=1 STRING: ENSP00000222005
    E2F2Q142093, ENSP000003552494I2D: score=1 STRING: ENSP00000355249
    E2F3O007163, ENSP000002629044I2D: score=2 STRING: ENSP00000262904
    SNW1Q135732, ENSP000002615314MINT-7945693 STRING: ENSP00000261531
    CCNB2O950673I2D: score=8 
    CDC6Q997413I2D: score=4 
    CLUHO751533I2D: score=4 
    FZR1Q9UM113I2D: score=4 
    GYS1P138073I2D: score=4 
    HSPA9P386463I2D: score=3 
    ACTR8Q9H9813I2D: score=2 
    CBSP355203I2D: score=2 
    CDC7O003113I2D: score=2 
    EEF2P136393I2D: score=2 
    KPNA6O606843I2D: score=2 
    PAK3O759143I2D: score=2 
    PSMD8P485563I2D: score=2 
    SIN3AQ96ST33I2D: score=2 
    ACTR5Q9H9F93I2D: score=1 
    ANAPC10Q9UM133I2D: score=1 
    ARFGAP1Q8N6T33I2D: score=1 
    ARL1P406163I2D: score=1 
    ARRB2P321213I2D: score=1 
    ASF1AQ9Y2943I2D: score=1 
    ASS1P009663I2D: score=1 
    ATAD2Q6PL183I2D: score=1 
    ATP5C1P365423I2D: score=1 
    ATP6V1B2P212813I2D: score=1 
    AURKCQ9UQB93I2D: score=1 
    BUD31P412233I2D: score=1 
    CADP277083I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    CCBL1Q167733I2D: score=1 
    CDC14AQ9UNH53I2D: score=1 
    CDC34P494273I2D: score=1 
    CDK7P506133I2D: score=1 
    DDX11L8A8MPP13I2D: score=1 
    DDX27Q96GQ73I2D: score=1 
    DDX6P261963I2D: score=1 
    DNA2P515303I2D: score=1 
    DUS3LQ96G463I2D: score=1 
    EIF2AQ9BY443I2D: score=1 
    EIF2B1Q142323I2D: score=1 
    EIF2B2P497703I2D: score=1 
    EIF2B4Q9UI103I2D: score=1 
    EIF5AP632413I2D: score=1 
    EPS15L1Q9UBC23I2D: score=1 
    GFPT2O948083I2D: score=1 
    GMPPBQ9Y5P63I2D: score=1 
    GNB2L1P632443I2D: score=1 
    GOT1P171743I2D: score=1 
    GTF2BQ004033I2D: score=1 
    HIST1H2BHQ930793I2D: score=1 
    HIST2H2BFQ5QNW63I2D: score=1 
    ICKQ9UPZ93I2D: score=1 
    ING3Q9NXR83I2D: score=1 
    IP6K3Q96PC23I2D: score=1 
    IPO4Q8TEX93I2D: score=1 
    KIF3BO150663I2D: score=1 
    KIFC3Q9BVG83I2D: score=1 
    LDHDQ86WU23I2D: score=1 
    LIASO437663I2D: score=1 
    LPIN3Q9BQK83I2D: score=1 
    MAD2L1Q132573I2D: score=1 
    MAPK1P284823I2D: score=1 
    MARCH6O603373I2D: score=1 
    MAT1AQ002663I2D: score=1 
    MCM3P252053I2D: score=1 
    MOB1AQ9H8S93I2D: score=1 
    MON1AQ86VX93I2D: score=1 
    MYO1EQ129653I2D: score=1 
    NAA20P615993I2D: score=1 
    NAP1L4Q997333I2D: score=1 
    NSUN2Q08J233I2D: score=1 
    ODC1P119263I2D: score=1 
    PAN2Q504Q33I2D: score=1 
    PAN3Q58A453I2D: score=1 
    PCNAP120043I2D: score=1 
    PFDN5Q994713I2D: score=1 
    PFKLP178583I2D: score=1 
    PIKFYVEQ9Y2I73I2D: score=1 
    PLAAQ9Y2633I2D: score=1 
    POLA1P098843I2D: score=1 
    POLE2P562823I2D: score=1 
    PPATQ062033I2D: score=1 
    PPP2R2DQ66LE63I2D: score=1 
    PPP3R1P630983I2D: score=1 
    PPP6CO007433I2D: score=1 
    PRKCEQ021563I2D: score=1 
    PSMB2P497213I2D: score=1 
    PSMD14O004873I2D: score=1 
    PSMD4P550363I2D: score=1 
    PYGLP067373I2D: score=1 
    RAD51Q066093I2D: score=1 
    RCC1P187543I2D: score=1 
    RPA1P276943I2D: score=1 
    RPL36AP838813I2D: score=1 
    RPS5P467823I2D: score=1 
    RPSAP088653I2D: score=1 
    RRM2P313503I2D: score=1 
    RSL24D1Q9UHA33I2D: score=1 
    SRMP196233I2D: score=1 
    SSU72Q9NP773I2D: score=1 
    STIP1P319483I2D: score=1 
    STK38LQ9Y2H13I2D: score=1 
    SUPT3HO754863I2D: score=1 
    TADA2AO754783I2D: score=1 
    TCEA1P231933I2D: score=1 
    TOP1P113873I2D: score=1 
    TOP3AQ134723I2D: score=1 
    UBE2AP494593I2D: score=1 
    UBE4BO951553I2D: score=1 
    USP4Q131073I2D: score=1 
    USP7Q930093I2D: score=1 
    VAC14Q08AM63I2D: score=1 
    XPO5Q9HAV43I2D: score=1 
    YEATS4O956193I2D: score=1 
    ABCF1Q8NE712MINT-7945693
    ABCF3Q9NUQ82MINT-7945693
    ACIN1Q9UKV32MINT-7945693
    ACTBP607092MINT-7945693
    ACTL6AO960192MINT-7945693
    ACTR1AP611632MINT-7945693
    ACTR2P611602MINT-7945693
    ADNPQ9H2P02MINT-7945693
    AHNAKQ096662MINT-7945693
    AK6Q165942MINT-7945693
    ANAPC1Q9H1A42MINT-7945693
    ANLNQ9NQW62MINT-7945693
    AP1B1Q105672MINT-7945693
    AP3B1O002032MINT-7945693
    APBB1IPQ7Z5R62MINT-7945693
    API5Q9BZZ52MINT-7945693
    AQRO603062MINT-7945693
    ARAP1Q96P482MINT-7945693
    ARCN1P484442MINT-7945693
    ARF4P180852MINT-7945693
    ARF5P840852MINT-7945693
    ARFGEF2Q9Y6D52MINT-7945693
    ARHGEF1Q928882MINT-7945693
    ARHGEF2Q929742MINT-7945693
    ARID1AO144972MINT-7945693
    ASUNQ9NVM92MINT-7945693
    ATMQ133152MINT-7945693
    ATRXP461002MINT-7945693
    AURKAO149652MINT-7945693
    AURKBQ96GD42MINT-7945693
    BABAM1Q9NWV82MINT-7945693
    BAZ1AQ9NRL22MINT-7945693
    BCAS2O759342MINT-7945693
    BCL7CQ8WUZ02MINT-7945693
    BCLAF1Q9NYF82MINT-7945693
    BLMP541322MINT-7945693
    BRD8Q9H0E92MINT-7945693
    BRIX1Q8TDN62MINT-7945693
    BTAF1O149812MINT-7945693
    BUB1BO605662MINT-7945693
    BUB3O436842MINT-7945693
    BZW1Q7L1Q62MINT-7945693
    BZW2Q9Y6E22MINT-7945693
    C7orf55-LUC7L2Q9Y3832MINT-7945693
    CAND1Q86VP62MINT-7945693
    CAPGP401212MINT-7945693
    CAPZA1P529072MINT-7945693
    CCNB1P146352MINT-7945693
    CCNT1O605632MINT-7945693
    CCT4P509912MINT-7945693
    CCT5P486432MINT-7945693
    CCT6AP402272MINT-7945693
    CCT8P509902MINT-7945693
    CDC5LQ994592MINT-7945693
    CDC73Q6P1J92MINT-7945693
    CDK1P064932MINT-7945693
    CDK12Q9NYV42MINT-7945693
    CDK9P507502MINT-7945693
    CDKN2AIPQ9NXV62MINT-7945693
    CHD1LQ86WJ12MINT-7945693
    CHD3Q128732MINT-7945693
    CHD4Q148392MINT-7945693
    CHD7Q9P2D12MINT-7945693
    CHD8Q9HCK82MINT-7945693
    CHEK1O147572MINT-7945693
    CKAP5Q140082MINT-7945693
    CLP1Q929892MINT-7945693
    COPAP536212MINT-7945693
    COPB1P536182MINT-7945693
    COPB2P356062MINT-7945693
    COPG1Q9Y6782MINT-7945693
    COPG2Q9UBF22MINT-7945693
    COPS3Q9UNS22MINT-7945693
    COPS5Q929052MINT-7945693
    COPS6Q7L5N12MINT-7945693
    CPNE3O751312MINT-7945693
    CPSF1Q105702MINT-7945693
    CPSF2Q9P2I02MINT-7945693
    CPSF3Q9UKF62MINT-7945693
    CPSF4O956392MINT-7945693
    CPSF7Q8N6842MINT-7945693
    CSE1LP550602MINT-7945693
    CSKP412402MINT-7945693
    CSTF3Q129962MINT-7945693
    CTTNQ142472MINT-7945693
    CUL1Q136162MINT-7945693
    DCTN1Q142032MINT-7945693
    DCTN2Q135612MINT-7945693
    DDX1Q924992MINT-7945693
    DDX17Q928412MINT-7945693
    DDX19BQ9UMR22MINT-7945693
    DDX21Q9NR302MINT-7945693
    DDX23Q9BUQ82MINT-7945693
    DDX39AO001482MINT-7945693
    DDX39BQ138382MINT-7945693
    DDX3XO005712MINT-7945693
    DDX41Q9UJV92MINT-7945693
    DDX42Q86XP32MINT-7945693
    DDX46Q7L0142MINT-7945693
    DDX5P178442MINT-7945693
    DEPDC7Q96QD52MINT-7945693
    DFNA5O604432MINT-7945693
    DHX8Q145622MINT-7945693
    DHX9Q082112MINT-7945693
    DIAPH3Q9NSV42MINT-7945693
    DIDO1Q9BTC02MINT-7945693
    DMAP1Q9NPF52MINT-7945693
    DNAJC13O751652MINT-7945693
    DNM1LO004292MINT-7945693
    DNM2P505702MINT-7945693
    DOCK1Q141852MINT-7945693
    DOCK2Q926082MINT-7945693
    DPF2Q927852MINT-7945693
    DRG1Q9Y2952MINT-7945693
    DSPP159242MINT-7945693
    DYNC1LI2O432372MINT-7945693
    EBNA1BP2Q998482MINT-7945693
    EEFSECP577722MINT-7945693
    EFTUD2Q150292MINT-7945693
    EHD1Q9H4M92MINT-7945693
    EHD4Q9H2232MINT-7945693
    EIF2S3P410912MINT-7945693
    EIF3EP602282MINT-7945693
    EIF3GO758212MINT-7945693
    EIF3HO153722MINT-7945693
    EIF3IQ133472MINT-7945693
    EIF3LQ9Y2622MINT-7945693
    EIF4A1P608422MINT-7945693
    EIF4A3P389192MINT-7945693
    EIF4G2P783442MINT-7945693
    EIF5BO608412MINT-7945693
    ELAVL1Q157172MINT-7945693
    ENAHQ8N8S72MINT-7945693
    ENSG00000096150P622692MINT-7945693
    ENSG00000183311P074372MINT-7945693
    ENSG00000206287Q065872MINT-7945693
    ENSG00000206490Q8NE712MINT-7945693
    ENSG00000215425Q138382MINT-7945693
    ENSG00000223367P622692MINT-7945693
    ENSG00000224156P074372MINT-7945693
    ENSG00000225073Q138382MINT-7945693
    ENSG00000225859Q138382MINT-7945693
    ENSG00000225989Q8NE712MINT-7945693
    ENSG00000226225P622692MINT-7945693
    ENSG00000226788Q065872MINT-7945693
    ENSG00000227739P074372MINT-7945693
    ENSG00000228520Q065872MINT-7945693
    ENSG00000229496Q138382MINT-7945693
    ENSG00000229684P074372MINT-7945693
    ENSG00000230624Q138382MINT-7945693
    ENSG00000231115Q065872MINT-7945693
    ENSG00000231129Q8NE712MINT-7945693
    ENSG00000232169Q8NE712MINT-7945693
    ENSG00000232421P074372MINT-7945693
    ENSG00000232575P074372MINT-7945693
    ENSG00000235067P074372MINT-7945693
    ENSG00000235107Q065872MINT-7945693
    ENSG00000235439Q138382MINT-7945693
    ENSG00000235650P622692MINT-7945693
    ENSG00000236149Q8NE712MINT-7945693
    ENSG00000236342Q8NE712MINT-7945693
    EPPK1P581072MINT-7945693
    EPS8L2Q9H6S32MINT-7945693
    ETF1P624952MINT-7945693
    ETV6P412122MINT-7945693
    EXOC1Q9NV702MINT-7945693
    EXOC2Q96KP12MINT-7945693
    EXOC3O606452MINT-7945693
    EXOC4Q96A652MINT-7945693
    EXOC5O004712MINT-7945693
    EXOC7Q9UPT52MINT-7945693
    EXOSC6Q5RKV62MINT-7945693
    FAM105BQ96BN82MINT-7945693
    FAM129BQ96TA12MINT-7945693
    FANCIQ9NVI12MINT-7945693
    FASNP493272MINT-7945693
    FERMT1Q9BQL62MINT-7945693
    FHOD1Q9Y6132MINT-7945693
    FIP1L1Q6UN152MINT-7945693
    FUBP1Q96AE42MINT-7945693
    FUSP356372MINT-7945693
    FYTTD1Q96QD92MINT-7945693
    G3BP2Q9UN862MINT-7945693
    GATAD2AQ86YP42MINT-7945693
    GATAD2BQ8WXI92MINT-7945693
    GEMIN4P576782MINT-7945693
    GNA14O958372MINT-7945693
    GSPT1P151702MINT-7945693
    GTF2IP783472MINT-7945693
    GTF3C1Q127892MINT-7945693
    GTF3C2Q8WUA42MINT-7945693
    GTF3C3Q9Y5Q92MINT-7945693
    GTF3C4Q9UKN82MINT-7945693
    GTPBP4Q9BZE42MINT-7945693
    GULP1Q9UBP92MINT-7945693
    HBS1LQ9Y4502MINT-7945693
    HDAC1Q135472MINT-7945693
    HDAC2Q927692MINT-7945693
    HDLBPQ003412MINT-7945693
    HELLSQ9NRZ92MINT-7945693
    HIP1RO751462MINT-7945693
    HIRAP541982MINT-7945693
    HNRNPA0Q131512MINT-7945693
    HNRNPA1P096512MINT-7945693
    HNRNPA2B1P226262MINT-7945693
    HNRNPA3P519912MINT-7945693
    HNRNPABQ997292MINT-7945693
    HNRNPCP079102MINT-7945693
    HNRNPDQ141032MINT-7945693
    HNRNPFP525972MINT-7945693
    HNRNPH1P319432MINT-7945693
    HNRNPKP619782MINT-7945693
    HNRNPMP522722MINT-7945693
    HNRNPRO433902MINT-7945693
    HNRNPUQ008392MINT-7945693
    HSP90AA1P079002MINT-7945693
    HSP90AB1P082382MINT-7945693
    HSP90B1P146252MINT-7945693
    HSPA12AO433012MINT-7945693
    HSPA5P110212MINT-7945693
    HSPA8P111422MINT-7945693
    HSPB1P047922MINT-7945693
    HTATSF1O437192MINT-7945693
    IKQ131232MINT-7945693
    ILF2Q129052MINT-7945693
    ILF3Q129062MINT-7945693
    ILKQ134182MINT-7945693
    INTS1Q8N2012MINT-7945693
    INTS12Q96CB82MINT-7945693
    INTS3Q68E012MINT-7945693
    IPO5O004102MINT-7945693
    IPO9Q96P702MINT-7945693
    IQGAP1P469402MINT-7945693
    KDM1AO603412MINT-7945693
    KHDRBS1Q076662MINT-7945693
    KIAA1279Q96EK52MINT-7945693
    KIF21AQ7Z4S62MINT-7945693
    KIF27Q86VH22MINT-7945693
    KIF2CQ996612MINT-7945693
    KIF4AO952392MINT-7945693
    KMT2DO146862MINT-7945693
    KPNA1P522942MINT-7945693
    KPNA2P522922MINT-7945693
    KPNB1Q149742MINT-7945693
    KTI12Q96EK92MINT-7945693
    LDLRAP1Q5SW962MINT-7945693
    LIMS1P480592MINT-7945693
    LMNAP025452MINT-7945693
    LRRC40Q9H9A62MINT-7945693
    LRRC47Q8N1G42MINT-7945693
    LRWD1Q9UFC02MINT-7945693
    LUC7L2Q9Y3832MINT-7945693
    MAD1L1Q9Y6D92MINT-7945693
    MAGED2Q9UNF12MINT-7945693
    MAP2K2P365072MINT-7945693
    MAP2K3P467342MINT-7945693
    MAP2K7O147332MINT-7945693
    MATR3P432432MINT-7945693
    MBD3O959832MINT-7945693
    MDN1Q9NU222MINT-7945693
    MED4Q9NPJ62MINT-7945693
    METTL13Q8N6R02MINT-7945693
    MLKLQ8NB162MINT-7945693
    MORF4L1Q9UBU82MINT-7945693
    MORF4L2Q150142MINT-7945693
    MTA2O947762MINT-7945693
    MVPQ147642MINT-7945693
    MYH9P355792MINT-7945693
    MYO15BQ96JP22MINT-7945693
    NACC1Q96RE72MINT-7945693
    NBNO609342MINT-7945693
    NCAPGQ9BPX32MINT-7945693
    NCAPHQ150032MINT-7945693
    NCLP193382MINT-7945693
    NCOR1O753762MINT-7945693
    NCOR2Q9Y6182MINT-7945693
    NDC80O147772MINT-7945693
    NELFBQ8WX922MINT-7945693
    NELFCDQ8IXH72MINT-7945693
    NFICP086512MINT-7945693
    NIPBLQ6KC792MINT-7945693
    NOLC1Q149782MINT-7945693
    NONOQ152332MINT-7945693
    NR2C2P491162MINT-7945693
    NR2F2P244682MINT-7945693
    NR2F6P105882MINT-7945693
    NSFP464592MINT-7945693
    NSUN5Q96P112MINT-7945693
    NUDCQ9Y2662MINT-7945693
    NUF2Q9BZD42MINT-7945693
    NUP153P497902MINT-7945693
    NUP155O756942MINT-7945693
    NUP37Q8NFH42MINT-7945693
    OLA1Q9NTK52MINT-7945693
    ORC2Q134162MINT-7945693
    ORC3Q9UBD52MINT-7945693
    OXSR1O957472MINT-7945693
    PABPC1P119402MINT-7945693
    PABPN1Q86U422MINT-7945693
    PAK1Q131532MINT-7945693
    PAK4O960132MINT-7945693
    PARP4Q9UKK32MINT-7945693
    PARVAQ9NVD72MINT-7945693
    PARVBQ9HBI12MINT-7945693
    PAXIP1Q6ZW492MINT-7945693
    PBRM1Q86U862MINT-7945693
    PCBP2Q153662MINT-7945693
    PCF11O949132MINT-7945693
    PDCD6IPQ8WUM42MINT-7945693
    PDLIM7Q9NR122MINT-7945693
    PELP1Q8IZL82MINT-7945693
    PFKMP082372MINT-7945693
    PFKPQ018132MINT-7945693
    PHGDHO431752MINT-7945693
    PICALMQ134922MINT-7945693
    PIK3R4Q995702MINT-7945693
    PKN2Q165132MINT-7945693
    PKP3Q9Y4462MINT-7945693
    PLECQ151492MINT-7945693
    PLRG1O436602MINT-7945693
    PNNQ9H3072MINT-7945693
    POGZQ7Z3K32MINT-7945693
    POLD1P283402MINT-7945693
    POLEQ078642MINT-7945693
    POLR1CO151602MINT-7945693
    POLR2EP193882MINT-7945693
    PPP1CAP621362MINT-7945693
    PPP2R1AP301532MINT-7945693
    PPP2R1BP301542MINT-7945693
    PRKAG1P546192MINT-7945693
    PRKDCP785272MINT-7945693
    PRPF19Q9UMS42MINT-7945693
    PRPF40AO754002MINT-7945693
    PRPF6O949062MINT-7945693
    PRPF8Q6P2Q92MINT-7945693
    PSMC1P621912MINT-7945693
    PSMC3P179802MINT-7945693
    PSMC4P436862MINT-7945693
    PSMC6P623332MINT-7945693
    PSMD11O002312MINT-7945693
    PSMD12O002322MINT-7945693
    PSMD13Q9UNM62MINT-7945693
    PTBP1P265992MINT-7945693
    PUF60Q9UHX12MINT-7945693
    PUM2Q8TB722MINT-7945693
    PURAQ005772MINT-7945693
    PWP1Q136102MINT-7945693
    RACGAP1Q9H0H52MINT-7945693
    RAD18Q9NS912MINT-7945693
    RAD21O602162MINT-7945693
    RAD50Q928782MINT-7945693
    RAE1P784062MINT-7945693
    RALYQ9UKM92MINT-7945693
    RANBP2P497922MINT-7945693
    RANGAP1P460602MINT-7945693
    RBBP7Q165762MINT-7945693
    RBM10P981752MINT-7945693
    RBM14Q96PK62MINT-7945693
    RBM15Q96T372MINT-7945693
    RBM17Q96I252MINT-7945693
    RBM39Q144982MINT-7945693
    RBM4Q9BWF32MINT-7945693
    RBM45Q8IUH32MINT-7945693
    RBMXP381592MINT-7945693
    RCOR1Q9UKL02MINT-7945693
    RFC2P352502MINT-7945693
    RFC4P352492MINT-7945693
    RFC5P409372MINT-7945693
    RIF1Q5UIP02MINT-7945693
    RING1Q065872MINT-7945693
    RIOK1Q9BRS22MINT-7945693
    RNF2Q994962MINT-7945693
    ROCK2O751162MINT-7945693
    RPL12P300502MINT-7945693
    RPL13P263732MINT-7945693
    RPL19P840982MINT-7945693
    RPL22P352682MINT-7945693
    RPL23AP627502MINT-7945693
    RPL3P390232MINT-7945693
    RPL31P628992MINT-7945693
    RPL36Q9Y3U82MINT-7945693
    RPL7AP624242MINT-7945693
    RPL8P629172MINT-7945693
    RPS14P622632MINT-7945693
    RPS18P622692MINT-7945693
    RPS19P390192MINT-7945693
    RPS25P628512MINT-7945693
    RPS6KA4O756762MINT-7945693
    RPS6KB2Q9UBS02MINT-7945693
    RTCBQ9Y3I02MINT-7945693
    RUVBL2Q9Y2302MINT-7945693
    SART1O432902MINT-7945693
    SCYL2Q6P3W72MINT-7945693
    SEC23BQ154372MINT-7945693
    SEC31BQ9NQW12MINT-7945693
    SEH1LQ96EE32MINT-7945693
    SEPT9Q9UHD82MINT-7945693
    SETXQ7Z3332MINT-7945693
    SF3A1Q154592MINT-7945693
    SF3A3Q128742MINT-7945693
    SF3B1O755332MINT-7945693
    SF3B14Q9Y3B42MINT-7945693
    SF3B2Q134352MINT-7945693
    SF3B3Q153932MINT-7945693
    SF3B4Q154272MINT-7945693
    SFPQP232462MINT-7945693
    SHOC2Q9UQ132MINT-7945693
    SHROOM3Q8TF722MINT-7945693
    SMARCA2P515312MINT-7945693
    SMARCA5O602642MINT-7945693
    SMARCAD1Q9H4L72MINT-7945693
    SMARCB1Q128242MINT-7945693
    SMARCC1Q929222MINT-7945693
    SMARCC2Q8TAQ22MINT-7945693
    SMARCD1Q96GM52MINT-7945693
    SMARCE1Q969G32MINT-7945693
    SMC1AQ146832MINT-7945693
    SMC2O953472MINT-7945693
    SMC3Q9UQE72MINT-7945693
    SMCHD1A6NHR92MINT-7945693
    SMN1Q166372MINT-7945693
    SMN2Q166372MINT-7945693
    SND1Q7KZF42MINT-7945693
    SNRNP200O756432MINT-7945693
    SNRNP40Q96DI72MINT-7945693
    SNRNP70P086212MINT-7945693
    SNRPB2P085792MINT-7945693
    SNRPD3P623182MINT-7945693
    SNUPNO951492MINT-7945693
    SPATA5Q8NB902MINT-7945693
    SPATA5L1Q9BVQ72MINT-7945693
    SPTAN1Q138132MINT-7945693
    SPTBN1Q010822MINT-7945693
    SQSTM1Q135012MINT-7945693
    SRP19P091322MINT-7945693
    SRP54P610112MINT-7945693
    SRP68Q9UHB92MINT-7945693
    SRP72O760942MINT-7945693
    SRRM1Q8IYB32MINT-7945693
    SRRM2Q9UQ352MINT-7945693
    SRSF1Q079552MINT-7945693
    SRSF11Q055192MINT-7945693
    SRSF2Q011302MINT-7945693
    SRSF3P841032MINT-7945693
    SRSF5Q132432MINT-7945693
    SRSF6Q132472MINT-7945693
    SRSF7Q166292MINT-7945693
    STAG1Q8WVM72MINT-7945693
    SUGT1Q9Y2Z02MINT-7945693
    SUPV3L1Q8IYB82MINT-7945693
    SYMPKQ927972MINT-7945693
    SYNCRIPO605062MINT-7945693
    TAF12Q165142MINT-7945693
    TAF9Q165942MINT-7945693
    TAOK1Q7L7X32MINT-7945693
    TARDBPQ131482MINT-7945693
    TBL1XR1Q9BZK72MINT-7945693
    THOC1Q96FV92MINT-7945693
    THOC2Q8NI272MINT-7945693
    THRAP3Q9Y2W12MINT-7945693
    TIAL1Q010852MINT-7945693
    TLN1Q9Y4902MINT-7945693
    TMPOP421662MINT-7945693
    TOX4O948422MINT-7945693
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS8846921
    GO:0006468protein phosphorylation ----
    GO:0007067mitosis IEA--
    GO:0008283cell proliferation TAS18794154
    GO:0045023G0 to G1 transition TAS15084261

    CDK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for CDK3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK3

    2 HMDB Compounds for CDK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about CDK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CDK3 gene: 
    NM_001258.2  

    Unigene Cluster for CDK3:

    Cyclin-dependent kinase 3
    Hs.706766  [show with all ESTs]
    Unigene Representative Sequence: NR_037709
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588812 ENST00000425876 ENST00000586261 ENST00000448471
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    NR_037709.1 X66357.1 

    6 DOTS entries:

    DT.302659  DT.95164072  DT.92434871  DT.97768995  DT.121007869  DT.455141 

    24/138 AceView cDNA sequences (see all 138):

    CK904002 CF128049 AU120188 CR604264 CD671351 BM053162 BC047782 BQ962463 
    BU785194 AI565655 BM907267 BM053101 BM671003 BM706946 BQ189457 AI131108 
    AI468903 BQ772353 X66357 BU728264 BU623401 BE782476 AI670081 AW612926 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGAGGGGT
    CDK3 Expression
    About this image


    See CDK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK3

    SOURCE GeneReport for Unigene cluster: Hs.706766

    UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526
    Tissue specificity: Expressed in cancer cell lines and glioblastoma tissue

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK3 gene from 8/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk3-ps5 cyclin-dependent kinase 3, pseudogene   --   11 (81.02 cM) 116216003 
    chicken
    (Gallus gallus)
    Aves CDK31 cyclin-dependent kinase 3 75.67(n)
    81.33(a)
      429642  NM_001081706.2  NP_001075175.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDK36
    Uncharacterized protein
    75(a)
    1 ↔ 1
    2(113303478-113320825)
    fruit fly
    (Drosophila melanogaster)
    Insecta cdc23 G2/M transition of mitotic cell cycle
    protein more
    65(a)
    (best of 4)
      31D11   --
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-13 serine/threonine kinase (CDC2/CDKX
    subfamily)
    63(a)
    (best of 3)
      III(9819189-9820383)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC286
    Catalytic subunit of the main cell cycle cyclin-de...
    62(a)
    1 → many
    II(560078-560974)
    soybean
    (Glycine max)
    eudicotyledons Gma.131182 Glycine max cv Prize protein kinase mRNA. 74.36(n)    M93140.1 
    wheat
    (Triticum aestivum)
    Liliopsida Ta.66752 Triticum aestivum p34cdc2 (cdc2TaB) mRNA, partial cds 78.66(n)    U23410.1 


    ENSEMBL Gene Tree for CDK3 (if available)
    TreeFam Gene Tree for CDK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK3 gene
    CDK182  CDK62  CDK52  CDK152  CDK12  CDK42  CDK142  CDK162  
    CDK22  CDK172  
    18/96 SIMAP similar genes for CDK3 using alignment to 3 protein entries:     CDK3_HUMAN (see all proteins) (see all similar genes):
    CDK1    CDC2    CDK5    DKFZp686L20222    CDK18    CDK2
    PCTK1    PHKG2    CDK17    CDK16    STK3    PCTK3
    CDK14    CDK15    NDUFA9    CDC2L2    CDK7    CDK6

    CDK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    5 SNPs in CDK3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419734
    A glioblastoma multiforme sample4--see VAR_0419732 S N mis40--------
    VAR_0419744
    ----see VAR_0419742 I T mis40--------
    VAR_0211024
    ----see VAR_0211022 M T mis40--------
    VAR_0211014
    ----see VAR_0211012 T I mis40--------
    VAR_0419754
    ----see VAR_0419752 R H mis40--------

    HapMap Linkage Disequilibrium report for CDK3 (73996987 - 74002080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CDK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908826CNV Loss21882294
    nsv833546CNV Loss17160897
    nsv908825CNV Loss21882294
    nsv908824CNV Loss21882294
    dgv3270n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123828    OMIM disorders: --

    6 diseases for CDK3:    About MalaCards
    retinoblastoma    herpes simplex    glioblastoma    sarcoma
    hepatocellular carcinoma    neuronitis


    CDK3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CDK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 7882308 (2)
    cancer 0 2 18794154 (1), 7882308 (1)


    Export disorders for CDK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK3 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with CDK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3, 9 Meyerson M.... Tsai L.-H. (1992)
    2. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. (PubMed id 18794154)1, 2, 9 Zheng D....Dong Z. (2008)
    3. Cyclin C/cdk3 promotes Rb-dependent G0 exit. (PubMed id 15084261)1, 2 Ren S. and Rollins B.J. (2004)
    4. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. (PubMed id 8846921)1, 2 Hofmann F. and Livingston D.M. (1996)
    5. Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. (PubMed id 9811456)1, 9 Braun K....Hengstschlager M. (1998)
    6. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PubMed id 11733001)1, 9 Yamochi T....Matsuoka M. (2001)
    7. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. (PubMed id 7882308)1, 9 Bullrich F....Croce C.M. (1995)
    8. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. (PubMed id 9190208)1, 9 Connell-Crowley L....Goodrich D.W. (1997)
    9. Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells. (PubMed id 8626531)1, 9 Sasaguri T....Ogata J. (1996)
    10. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. (PubMed id 8242750)1, 9 Gyuris J.... Brent R. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1018 HGNC: 1772 AceView: CDK3 Ensembl:ENSG00000250506 euGenes: HUgn1018
    ECgene: CDK3 H-InvDB: CDK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK3 gene:
    Search GeneIP for patents involving CDK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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