Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CDK3 Gene

protein-coding   GIFtS: 53
GCID: GC17P073996

Cyclin-Dependent Kinase 3

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cyclin-Dependent Kinase 31 2
Cell Division Protein Kinase 32 3
EC 2.7.11.223 8
CDKN33
EC 2.7.118

External Ids:    HGNC: 17721   Entrez Gene: 10182   Ensembl: ENSG000002505067   OMIM: 1238285   UniProtKB: Q005263   

Export aliases for CDK3 gene to outside databases

Previous GC identifers: GC17M073921 GC17P077001 GC17P074439 GC17P074572 GC17P074594 GC17P071486 GC17P073977 GC17P069422


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CDK3 Gene:
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase,
in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin
C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDK3 Gene:
CDK3 (cyclin-dependent kinase 3) is a protein-coding gene. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK6.

UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526
Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle;
involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates
histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional
activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is
required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2
and E2F3 in a RB1-independent manner

Gene Wiki entry for CDK3 (Cyclin-dependent kinase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the CDK3 gene promoter:
         HOXA9   HOXA9B   AML1a   Pax-5   RelA   AP-4   CUTL1   Meis-1b   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK3 promoter sequence
   Search Chromatin IP Primers for CDK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

CDK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P073996:  view genomic region     (about GC identifiers)

Start:
73,996,987 bp from pter      End:
74,002,080 bp from pter
Size:
5,094 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 3  
Size: 305 amino acids; 35046 Da
Subunit: Interacts with CABLES1 and CABLES2 (By similarity). Interacts with ATF1. Binding to CCNC/cyclin-C
promotes RB1 phosphorylation
1 PDB 3D structure from and Proteopedia for CDK3:
1LFN (3D)    

Explore the universe of human proteins at neXtProt for CDK3: NX_Q00526

Explore proteomics data for CDK3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys9
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK3 (Q00526) (see all 17)
     VIHRDLK  VVTLWYR  DFGLARA  EGVPSTA 


    See CDK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001249.1  
    ENSEMBL proteins: 
     ENSP00000466237   ENSP00000410561   ENSP00000465062   ENSP00000400088  

    CDK3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CDK3 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CDK3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CDK3
    GenScript Custom Purified and Recombinant Proteins Services for CDK3
    Novus Biologicals CDK3 Proteins
    Novus Biologicals CDK3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CDK3
    Cloud-Clone Corp. Proteins for CDK3

     
    Search eBioscience for Proteins for CDK3 

     
    antibodies-online proteins for CDK3 (4 products) 

     
    antibodies-online peptides for CDK3

    CDK3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CDK3
    OriGene Custom Antibody Services for CDK3
    Novus Biologicals CDK3 Antibodies
    Search for Antibodies for CDK3 at Abcam
    Cloud-Clone Corp. Antibodies for CDK3
    ThermoFisher Antibodies for CDK3
    antibodies-online antibodies for CDK3 (37 products) 

    CDK3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK3
    Cloud-Clone Corp. CLIAs for CDK3
    Search eBioscience for ELISAs for CDK3 
    antibodies-online kits for CDK3 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 3
    CDK1 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q00526

    ProtoNet protein and cluster: Q00526

    UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK3_HUMAN, Q00526
    Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle;
    involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates
    histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional
    activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is
    required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2
    and E2F3 in a RB1-independent manner
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for CDK3:
    cyclin dependent kinase 3,involved in cell cycle regulation (G1 to S transition),not complexing with any cyclin

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CDK3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDK3:
     Actin fiber cells  Decreased substrate adherent c  Increased circadian period len 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CDK3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK3:
    hsa-mir-215-5p (MIRT024518), hsa-mir-192-5p (MIRT026751), hsa-mir-146a-5p (MIRT005705), hsa-mir-92a-3p (MIRT049159)

    Block miRNA regulation of human, mouse, rat CDK3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CDK3:
    hsa-miR-512-5p hsa-miR-214 hsa-miR-634 hsa-miR-1207-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidCDK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDK3
    Predesigned siRNA for gene silencing in human, mouse, rat CDK3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDK3

    Clone
    Products:
         
    OriGene clones in human, mouse for CDK3 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDK3 (NM_001258)
    Sino Biological Human cDNA Clone for CDK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK3
    Addgene plasmids for CDK3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDK3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CDK3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CDK3 About    
    See pathways by source

    SuperPathContained pathways About
    1GADD45 Pathway
    GADD45 Pathway
    2Cell Cycle Control of Chromosomal Replication
    Cell Cycle Control of Chromosomal Replication

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDK3
        Cell Cycle Control of Chromosomal Replication
    GADD45 Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK3
    Interactions:

        GeneGlobe Interaction Network for CDK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK3 (Q005262, 3 ENSP000004000884) via UniProtKB, MINT, STRING, and/or I2D (see all 921)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=3 
    HIST1H4BP628053I2D: score=3 
    HIST1H4CP628053I2D: score=3 
    HIST1H4DP628053I2D: score=3 
    HIST1H4EP628053I2D: score=3 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS8846921
    GO:0006468protein phosphorylation ----
    GO:0007067mitosis IEA--
    GO:0008283cell proliferation TAS18794154
    GO:0045023G0 to G1 transition TAS15084261

    Find genes that share ontologies with CDK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDK3

    2 HMDB Compounds for CDK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CDK3 gene: 
    NM_001258.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588812 ENST00000425876 ENST00000586261 ENST00000448471
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDK3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CDK3:
    hsa-miR-512-5p hsa-miR-214 hsa-miR-634 hsa-miR-1207-3p hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidCDK3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDK3
    Predesigned siRNA for gene silencing in human, mouse, rat CDK3
    Clone
    Products:
         
    OriGene clones in human, mouse for CDK3 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDK3 (NM_001258)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK3
    Addgene plasmids for CDK3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CDK3
      QuantiTect SYBR Green Assays in human, mouse, rat CDK3
      QuantiFast Probe-based Assays in human, mouse, rat CDK3

    138 AceView cDNA sequences (see top 24):

    AI565655 BM706946 BU785194 CD671351 AI131108 CR604264 BC047782 BM053101 
    BM053162 CK904002 AU120188 CF128049 BM907267 BQ189457 BM671003 BQ962463 
    BI858083 BU728264 BQ109222 BG287063 BU784937 BG394244 AI885421 BQ674947 
    BX647274 AA741490 BM916701 AW406168 AL556865 AI383733 AI468903 BM051009 
    BU623380 BG291518 X66357 AI022322 BQ045290 NM_001258 AI243138 AA863223 
    AI670081 BE252740 CB144705 BU623401 BI193083 BM808772 BM811357 BQ670254 
    BF308054 AA769456 BG186885 AI570630 BU735530 BX380432 BQ672153 BM919842 
    BM851716 AI272227 BF590503 BM696946 BI192807 AI371061 BG060084 BM807876 
    AI362715 AA648964 BQ772353 BM985295 BI858164 BE782476 AK097104 AI200233 
    BM558420 BX648576 BM449587 N35149 AW612926 BG431032 CA337130 BP371145 
    AW080869 BM015542 BI253773 N43899 N46052 AI869515 AI355775 AI338875 
    AA340111 AW249028 AI264370 AI141213 AW593062 BE798305 W74644 BE677868 
    AI302831 BX397737 BI192782 N26117 BE797623 AA724821 AA479754 AI884662 
    AI205276 BM712332 AA470853 BE712219 BE244361 AI033198 D20520 AW071013 
    BG474063 AU146328 BG743305 N89700 BX442609 BM010433 T66991 BM687706 
    BG202863 N36832 T66990 BG825104 AA760951 W94190 AW071955 W79300 
    W68716 W79305 BU752741 AI589101 W17177 N68352 BX328151 BU860495 
    BF215728 BG183716 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CDK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGAGGGGT
    CDK3 Expression
    About this image

    CDK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK3 Protein Expression

    UniProtKB/Swiss-Prot: CDK3_HUMAN, Q00526
    Tissue specificity: Expressed in cancer cell lines and glioblastoma tissue

        Custom PCR Arrays for CDK3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CDK3
    QuantiTect SYBR Green Assays in human, mouse, rat CDK3
    QuantiFast Probe-based Assays in human, mouse, rat CDK3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk3-ps5 cyclin-dependent kinase 3, pseudogene   --   11 (81.02 cM) 116216003 
    chicken
    (Gallus gallus)
    Aves CDK31 cyclin-dependent kinase 3 75.67(n)
    81.33(a)
      429642  NM_001081706.2  NP_001075175.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDK36
    cyclin-dependent kinase 3
    75(a)
    1 ↔ 1
    2(113303478-113320825)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-57f11.16
    si:dkeyp-57f11.1
    38(a)
    many ↔ many
    3(39170642-39174830) ENSDARG00000030163
    fruit fly
    (Drosophila melanogaster)
    Insecta cdc23 G2/M transition of mitotic cell cycle
    protein more
    65(a)
    (best of 4)
      31D11   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC286
    Catalytic subunit of the main cell cycle cyclin-de...
    62(a)
    1 → many
    II(560078-560974) YBR160W
    soybean
    (Glycine max)
    eudicotyledons Gma.131182 Glycine max cv Prize protein kinase mRNA. 74.36(n)    M93140.1 
    wheat
    (Triticum aestivum)
    Liliopsida Ta.66752 Triticum aestivum p34cdc2 (cdc2TaB) mRNA, partial cds 78.66(n)    U23410.1 


    ENSEMBL Gene Tree for CDK3 (if available)
    TreeFam Gene Tree for CDK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CDK3 gene
    CDK62  CDK22  CDK42  CDK12  
    Selected SIMAP similar genes for CDK3 using alignment to 3 protein entries:     CDK3_HUMAN (see all proteins) (see all similar genes):
    CDK1    CDC2    CDK5    DKFZp686L20222    CDK18    CDK2
    PCTK1    PHKG2    CDK17    CDK16    STK3    PCTK3
    CDK14    CDK15    CDC2L2    CDK7    CDK6    CDC2L1

    Find genes that share paralogs with CDK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    5 SNPs for CDK3    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419734
    A glioblastoma multiforme sample4--see VAR_0419732 S N mis40--------
    rs349184461,2,4
    ----see VAR_0419742 mis40--------
    rs178842511,2,4
    ----see VAR_0211022 mis40--------
    rs20695321,2,4
    ----see VAR_0211012 mis40--------
    rs346702671,2,4
    ----see VAR_0419752 mis40--------

    HapMap Linkage Disequilibrium report for CDK3 (73996987 - 74002080 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CDK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908826CNV Loss21882294
    nsv833546CNV Loss17160897
    nsv908825CNV Loss21882294
    nsv908824CNV Loss21882294
    dgv3270n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CDK3
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 123828    OMIM disorders: --


    Find genes that share disorders with CDK3           About GenesLikeMe

    2 Novoseek inferred disease relationships for CDK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 7882308 (2)
    cancer 0 2 18794154 (1), 7882308 (1)


    Export disorders for CDK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CDK3 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with CDK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2, 3, 9 Meyerson M.... Tsai L.-H. (EMBO J. 1992)
    2. Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. (PubMed id 18794154)1, 2, 9 Zheng D....Dong Z. (Cancer Res. 2008)
    3. Cyclin C/cdk3 promotes Rb-dependent G0 exit. (PubMed id 15084261)1, 2 Ren S. and Rollins B.J. (Cell 2004)
    4. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. (PubMed id 8846921)1, 2 Hofmann F. and Livingston D.M. (Genes Dev. 1996)
    5. Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. (PubMed id 9811456)1, 9 Braun K....HengstschlAoger M. (Oncogene 1998)
    6. ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). (PubMed id 11733001)1, 9 Yamochi T....Matsuoka M. (Eur. J. Biochem. 2001)
    7. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. (PubMed id 7882308)1, 9 Bullrich F....Croce C.M. (Cancer Res. 1995)
    8. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. (PubMed id 9190208)1, 9 Connell-Crowley L....Goodrich D.W. (Mol. Biol. Cell 1997)
    9. Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells. (PubMed id 8626531)1, 9 Sasaguri T....Ogata J. (J. Biol. Chem. 1996)
    10. Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. (PubMed id 8242750)1, 9 Gyuris J.... Brent R. (Cell 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1018 HGNC: 1772 AceView: CDK3 Ensembl:ENSG00000250506 euGenes: HUgn1018
    ECgene: CDK3 H-InvDB: CDK3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CDK3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CDK3 gene:
    Search GeneIP for patents involving CDK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant CDK3 Protein
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CDK3   OriGene RNAi products in human, mouse, rat for CDK3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CDK3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CDK3  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDK3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDK3   OriGene Custom Protein Services for CDK3  

     
     
     Block miRNA regulation of human, mouse, rat CDK3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CDK3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK3 Predesigned siRNA for gene silencing in human, mouse, rat CDK3
     QuantiFast Probe-based Assays in human, mouse, rat CDK3 QuantiTect SYBR Green Assays in human, mouse, rat CDK3
     Custom PCR Arrays for CDK3 Search Chromatin IP Primers for CDK3
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CDK3  GeneGlobe Interaction Network for CDK3
     Regulatory tfbs in CDK3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CDK3 GenScript cDNA clones with any tag delivered in your preferred vector for CDK3
     GenScript Custom Assay Services for CDK3 GenScript Custom overexpressing Cell Line Services for CDK3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CDK3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CDK3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CDK3 antibodies
     CDK3 proteins
     CDK3 lysates
     Search for Antibodies for CDK3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CDK3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CDK3
     Proteins for CDK3
     Antibodies for CDK3
     ELISAs for CDK3
     CLIAs for CDK3



     Browse ESI BIO Cell Lines and PureStem Progenitors for CDK3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK3
     SwitchGear 3'UTR luciferase reporter plasmids for CDK3
     SwitchGear Promoter luciferase reporter plasmids for CDK3
     ThermoFisher Antibodies for CDK3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK3
     Browse compounds at ApexBio
     Addgene plasmids for CDK3
      Search eBioscience for proteins for CDK3
      Search eBioscience for elisas for CDK3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CDK3
     antibodies-online antibodies for CDK3 (37 products)
     antibodies-online kits for CDK3 (2 products)
     antibodies-online peptides for CDK3
     antibodies-online proteins for CDK3 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDK3 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4