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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDK2AP2 Gene

protein-coding GIFtS: 48
GCID: GC11M067273

cyclin-dependent kinase 2 associated protein 2

(Previous name: CDK2-associated protein 2 )

Explore 2 diseases affiliated with
CDK2AP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 2 Associated Protein 2¹ ²		DOC-1-Related Protein² ³
DOC-1R¹ ² ³		Cyclin-Dependent Kinase 2-Associated Protein 2²
CDK2-Associated Protein 2¹ ² ³		Tumor Suppressor Deleted In Oral Cancer Related 1²
P14¹		DOC1R³

External Ids:	HGNC: 30833¹	Entrez Gene: 10263²	Ensembl: ENSG00000167797⁷	UniProtKB: O75956³

Export aliases for CDK2AP2 gene to outside databases

Previous GC identifers: GC11M067031 GC11M063603

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK2AP2:

This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated

with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for

this gene. (provided by RefSeq, Dec 2012)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDK2AP2 gene promoter:
PPAR-alpha Egr-3 Pax-5 Pax-6 Chx10 Olf-1 AP-2gamma Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK2AP2 promoter sequence

Search SABiosciences Chromatin IP Primers for CDK2AP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK2AP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13

CDK2AP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK2AP2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M067273: view genomic region (about GC identifiers)

Start:	67,273,968 bp from pter	End:	67,276,120 bp from pter
Size:	2,153 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDKA2_HUMAN, O75956 (See protein sequence)

Recommended Name: Cyclin-dependent kinase 2-associated protein 2

Size: 126 amino acids; 13101 Da

1 PDB 3D structure from and Proteopedia for CDK2AP2:

2M1L (3D)

Explore the universe of human proteins at neXtProt for CDK2AP2: NX_O75956

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75956

CDK2AP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001258778.1 NP_005842.1

ENSEMBL proteins:

ENSP00000301488 ENSP00000436213 ENSP00000431503

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDK2AP2 for domains About GeneDecksing

2 InterPro domains/families:

IPR017266 CDK2-associated_2

IPR019187 Cyclin-dep_kinase2-assoc_pr

Graphical View of Domain Structure for InterPro Entry O75956

ProtoNet protein and cluster: O75956

UniProtKB/Swiss-Prot: CDKA2_HUMAN, O75956

Similarity: Belongs to the CDK2AP family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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1 GenomeRNAi human phenotype for CDK2AP2:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDK2AP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/19 Interacting proteins for CDK2AP2 (O75956^{2, 3} ENSP00000301488⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PYCR1	P32322²^,³, ENSP00000328858⁴	MINT-8251260 I2D: score=2 STRING: ENSP00000328858
ENSG00000255835	P32322²^,³	MINT-8251260 I2D: score=2
A2M	P01023²^,³	MINT-8251164 I2D: score=2
DBN1	Q16643²^,³	MINT-8251175 I2D: score=2
EED	O75530²^,³	MINT-8251186 I2D: score=2

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDK2AP2
Search CenterWatch for drugs/clinical trials and news about CDK2AP2 / CDKA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CDK2AP2 gene (2 alternative transcripts):

NM_001271849.1 NM_005851.4

Unigene Cluster for CDK2AP2:

Cyclin-dependent kinase 2 associated protein 2

Hs.523835 [show with all ESTs]

Unigene Representative Sequence: BM926335

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000301488(uc001oma.3) ENST00000525402(uc009yry.3) ENST00000531178

ENST00000531506 ENST00000526447

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		hsa-miR-301b hsa-miR-548p hsa-miR-1321 hsa-miR-4254 hsa-miR-301a hsa-miR-512-3p hsa-miR-3666 hsa-miR-3907

		SwitchGear 3'UTR luciferase reporter plasmid: CDK2AP2 3' UTR sequence

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Additional cDNA sequence:

AF089814.1 AK001498.1 AK308725.1 AK310197.1 BC002850.2 BC016704.1 BT006909.1 CR457050.1

CR542042.1 NR_073484.1

6 DOTS entries:

DT.447036 DT.86821183 DT.120721430 DT.100810308 DT.91903253 DT.95216753

24/264 AceView cDNA sequences (see all 264):

BE906329 CA947142 CA946863 BM974632 BG105399 BU734385 BE732564 CA430632

BM846160 BE384737 CR615084 AA401965 BU624288 BM908287 CD518118 BQ270915

CR605710 BI754267 CR595755 AI089613 NM_005851 BQ924048 BG341208 BQ059251

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CDK2AP2 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d
SP1:									-		-						-
SP2:											-						-
SP3:																	-
SP4:									-		-
SP5:																	-

ECgene alternative splicing isoforms for CDK2AP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDK2AP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTGCCGAC

About this image

CDK2AP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Dorsal forebrain-like neurons (Generation of midbra...)

Brain

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDK2AP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDK2AP2

SOURCE GeneReport for Unigene cluster: Hs.523835

UniProtKB/Swiss-Prot: CDKA2_HUMAN, O75956

Tissue specificity: Ubiquitous

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CDK2AP2 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CDK2AP2⁶	--	84(a)	1 ↔ 1	1(90749138-90756155)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.6813²	Transcribed sequence with weak similarity to protein more	77.64(n)		CF782186.1
zebrafish (Danio rerio)	Actinopterygii	Dr.9481²	Transcribed sequence with weak similarity to protein more	77.78(n)		BQ093940.1
fruit fly (Drosophila melanogaster)	Insecta	CG18292⁶	--	19(a)	1 → many	X(11031915-11033726)

ENSEMBL Gene Tree for CDK2AP2 (if available)
TreeFam Gene Tree for CDK2AP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDK2AP2 gene

CDK2AP1²

2 SIMAP similar genes for CDK2AP2 using alignment to 3 protein entries: CDKA2_HUMAN (see all proteins):

DOC-1R CDK2AP1

CDK2AP2 for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for CDK2AP2
PGOHUM00000233128 PGOHUM00000236171 PGOHUM00000236546 PGOHUM00000236582

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184354562^1,2	C,	--	67274845(+)	`CTTCAA/GGCGCT`	2	L	syn¹		0	--	--	--	--
rs200567964^1,2		--	67274993(+)	`GGCAGG/TGAGCT`	1	--	int¹		0	--	--	--	--
rs202184381^1,2	C,	--	67274999(+)	`GAGCTC/GAGGCA`	1	--	int¹		1		EU	1169
rs144468375^1,2	C,F,	--	67275063(+)	`CTCACC/TTGCAC`	2	Q	syn¹		2		NA EU	5841
rs147979185^1,2		--	67275632(+)	`TCTGAC/TTGGCA`	1	--	ut5¹		0	--	--	--	--
rs11548606^1,2	C,F,	--	67275665(-)	`AGACCT/GCTATT`	1	--	ut5¹ ese³		1		WA	118
rs190123507^1,2		--	67275982(+)	`GGCGCA/GGGCGC`	1	--	ut5¹		0	--	--	--	--
rs149084964^1,2	C,	--	67276122(+)	`GGCCG-/AAGGAC`	1	--	us2k¹		0	--	--	--	--
rs1871044^1,2	F,	--	67276158(+)	`GCGCCC/GCACCC`	1	--	us2k¹		2		WA EA	238
rs3758941^1,2	C,F,H,	--	67276235(+)	`GAGGCC/ATGCGT`	1	--	us2k¹		11		NS EA NA	1526

HapMap Linkage Disequilibrium report for CDK2AP2 (67273968 - 67276120 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CDK2AP2
1 CNV: 5275

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDK2AP2 for disorders About GeneDecksing

2 diseases for CDK2AP2: About MalaCards

oral cancer carney complex

1 disease from the University of Copenhagen DISEASES database for CDK2AP2:

Hormone producing pituitary cancer

Export disorders for CDK2AP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDK2AP2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CDK2AP2)

Utopia: connect your pdf to the dynamic
world of online information

Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene. (PubMed id 10082655)^{1, 2, 3, 9} Zhang X.... Haluska F.G. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R). (PubMed id 14985111)¹ Buajeeb W....Wong D.T. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10263	HGNC: 30833	AceView: DOC-1R	Ensembl:ENSG00000167797	euGenes: HUgn10263
ECgene: CDK2AP2	H-InvDB: CDK2AP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDK2AP2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDK2AP2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CDK2AP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CDK2AP2 gene:
Search GeneIP for patents involving CDK2AP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for CDK2AP2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK2AP2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK2AP2
	OriGene Protein Over-expression Lysate for CDK2AP2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CDK2AP2		OriGene 3'-UTR Clone for CDK2AP2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK2AP2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK2AP2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
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	OriGene Purified Protein for CDK2AP2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK2AP2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK2AP2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK2AP2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK2AP2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK2AP2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK2AP2

	GenScript Custom Purified and Recombinant Proteins Services for CDK2AP2		GenScript cDNA clones with any tag delivered in your preferred vector for CDK2AP2
	GenScript Custom Assay Services for CDK2AP2		GenScript Custom Superior Antibodies Services for CDK2AP2
	GenScript Custom overexpressing Cell Line Services for CDK2AP2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	SwitchGear 3'UTR luciferase reporter plasmids for CDK2AP2
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK2AP2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CDK2AP2 gene at Home site.

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CDK2AP2 Gene

cyclin-dependent kinase 2 associated protein 2

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CDK2AP2 Gene

cyclin-dependent kinase 2 associated protein 2

Aliasesfor CDK2AP2 gene

Summariesfor CDK2AP2 gene

Genomic Viewsfor CDK2AP2 gene

Proteinsfor CDK2AP2 gene

Protein Domains /Familiesfor CDK2AP2 gene

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Genome Databases showing CDK2AP2 gene

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for CDK2AP2 gene

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for CDK2AP2 gene

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for CDK2AP2 gene

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