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Aliases for CDK2AP2 Gene

Aliases for CDK2AP2 Gene

  • Cyclin-Dependent Kinase 2 Associated Protein 2 2 3
  • CDK2-Associated Protein 2 2 3 4
  • Tumor Suppressor Deleted In Oral Cancer Related 1 2 3
  • DOC-1-Related Protein 3 4
  • DOC-1R 3 4
  • DOC1R 4
  • P14 3

External Ids for CDK2AP2 Gene

Previous GeneCards Identifiers for CDK2AP2 Gene

  • GC11M067031
  • GC11M067273
  • GC11M063603

Summaries for CDK2AP2 Gene

Entrez Gene Summary for CDK2AP2 Gene

  • This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for CDK2AP2 Gene

CDK2AP2 (Cyclin-Dependent Kinase 2 Associated Protein 2) is a Protein Coding gene. An important paralog of this gene is CDK2AP1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK2AP2 Gene

Genomics for CDK2AP2 Gene

Regulatory Elements for CDK2AP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDK2AP2 Gene

67,506,490 bp from pter
67,508,728 bp from pter
2,239 bases
Minus strand

Genomic View for CDK2AP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK2AP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK2AP2 Gene

Proteins for CDK2AP2 Gene

  • Protein details for CDK2AP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase 2-associated protein 2
    Protein Accession:

    Protein attributes for CDK2AP2 Gene

    126 amino acids
    Molecular mass:
    13101 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDK2AP2 Gene

neXtProt entry for CDK2AP2 Gene

Proteomics data for CDK2AP2 Gene at MOPED

Post-translational modifications for CDK2AP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK2AP2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CDK2AP2

No data available for DME Specific Peptides for CDK2AP2 Gene

Domains & Families for CDK2AP2 Gene

Protein Domains for CDK2AP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CDK2AP family.
  • Belongs to the CDK2AP family.
genes like me logo Genes that share domains with CDK2AP2: view

No data available for Gene Families for CDK2AP2 Gene

Function for CDK2AP2 Gene

genes like me logo Genes that share phenotypes with CDK2AP2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK2AP2 Gene

Localization for CDK2AP2 Gene

Subcellular locations from

Jensen Localization Image for CDK2AP2 Gene COMPARTMENTS Subcellular localization image for CDK2AP2 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDK2AP2 Gene

Pathways & Interactions for CDK2AP2 Gene

SuperPathways for CDK2AP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDK2AP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CDK2AP2 Gene

Drugs & Compounds for CDK2AP2 Gene

No Compound Related Data Available

Transcripts for CDK2AP2 Gene

Unigene Clusters for CDK2AP2 Gene

Cyclin-dependent kinase 2 associated protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK2AP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for CDK2AP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDK2AP2 Gene

mRNA expression in normal human tissues for CDK2AP2 Gene

SOURCE GeneReport for Unigene cluster for CDK2AP2 Gene Hs.523835

mRNA Expression by UniProt/SwissProt for CDK2AP2 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with CDK2AP2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CDK2AP2 Gene

Orthologs for CDK2AP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDK2AP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDK2AP2 35
  • 91.01 (n)
  • 98.41 (a)
CDK2AP2 36
  • 94 (a)
(Canis familiaris)
Mammalia CDK2AP2 35
  • 94.18 (n)
  • 99.21 (a)
CDK2AP2 36
  • 96 (a)
(Mus musculus)
Mammalia Cdk2ap2 35
  • 90.48 (n)
  • 98.41 (a)
Cdk2ap2 16
Cdk2ap2 36
  • 94 (a)
(Pan troglodytes)
Mammalia CDK2AP2 35
  • 99.21 (n)
  • 100 (a)
CDK2AP2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cdk2ap2 35
  • 91.01 (n)
  • 98.41 (a)
(Monodelphis domestica)
Mammalia CDK2AP2 36
  • 91 (a)
(Anolis carolinensis)
Reptilia CDK2AP2 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC89864 35
  • 68.61 (n)
  • 77.5 (a)
Str.6813 35
(Danio rerio)
Actinopterygii cdk2ap2 35
  • 69.97 (n)
  • 77.48 (a)
Dr.9481 35
cdk2ap2 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18292 36
  • 18 (a)
Species with no ortholog for CDK2AP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDK2AP2 Gene

Gene Tree for CDK2AP2 (if available)
Gene Tree for CDK2AP2 (if available)

Paralogs for CDK2AP2 Gene

Paralogs for CDK2AP2 Gene

(2) SIMAP similar genes for CDK2AP2 Gene using alignment to 3 proteins: Pseudogenes for CDK2AP2 Gene

genes like me logo Genes that share paralogs with CDK2AP2: view

Variants for CDK2AP2 Gene

Sequence variations from dbSNP and Humsavar for CDK2AP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs672432 -- 67,508,998(+) AACCG(C/T)CTGGG upstream-variant-2KB
rs687343 -- 67,509,983(+) AGGGG(A/G)CACTC upstream-variant-2KB
rs687376 -- 67,510,004(+) gactg(G/T)catgt upstream-variant-2KB
rs1871044 -- 67,508,687(+) GCGCC(C/G)CACCC upstream-variant-2KB, utr-variant-5-prime
rs3758941 -- 67,508,764(+) GAGGC(A/C)TGCGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDK2AP2 Gene

Variant ID Type Subtype PubMed ID
nsv897797 CNV Loss 21882294
nsv897801 CNV Loss 21882294
dgv1193n71 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
nsv521723 CNV Loss 19592680
nsv468604 CNV Loss 19166990
nsv527056 CNV Loss 19592680
esv2422195 CNV Duplication 17116639
nsv368 CNV Insertion 18451855

Variation tolerance for CDK2AP2 Gene

Residual Variation Intolerance Score: 62.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK2AP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK2AP2 Gene

Disorders for CDK2AP2 Gene

Relevant External Links for CDK2AP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDK2AP2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK2AP2 Gene

Publications for CDK2AP2 Gene

  1. Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene. (PMID: 10082655) Zhang X. … Haluska F.G. (Biochem. Biophys. Res. Commun. 1999) 2 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation. (PMID: 23781148) Liu Q. … Luo Y. (Int. J. Biol. Sci. 2013) 67
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 67

Products for CDK2AP2 Gene

Sources for CDK2AP2 Gene

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