Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDK2AP2 Gene

Aliases for CDK2AP2 Gene

  • Cyclin Dependent Kinase 2 Associated Protein 2 2 3 5
  • CDK2-Associated Protein 2 2 3 4
  • Tumor Suppressor Deleted In Oral Cancer Related 1 2 3
  • DOC-1-Related Protein 3 4
  • DOC-1R 3 4
  • Cyclin-Dependent Kinase 2-Associated Protein 2 3
  • DOC1R 4
  • P14 3

External Ids for CDK2AP2 Gene

Previous GeneCards Identifiers for CDK2AP2 Gene

  • GC11M067031
  • GC11M067273
  • GC11M063603

Summaries for CDK2AP2 Gene

Entrez Gene Summary for CDK2AP2 Gene

  • This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for CDK2AP2 Gene

CDK2AP2 (Cyclin Dependent Kinase 2 Associated Protein 2) is a Protein Coding gene. An important paralog of this gene is CDK2AP1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK2AP2 Gene

Genomics for CDK2AP2 Gene

Regulatory Elements for CDK2AP2 Gene

Enhancers for CDK2AP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F067503 1.2 ENCODE 7.6 +1.0 1047 7.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 CTSF ENSG00000258297 CDK2AP2 PTPRCAP PITPNM1
GH11F067579 1.4 Ensembl ENCODE 6.2 -75.5 -75501 10.5 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 ENSG00000255119 NUDT8 PTPRCAP RBM4B NDUFV1 ENSG00000258297 C11orf72 DOC2GP TBX10 ENSG00000255318
GH11F066891 1.6 FANTOM5 Ensembl ENCODE 4.9 +616.1 616137 1.8 PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 SLC30A9 FOS JUNB REST LOC105369353 RAD9A LRFN4 RBM4B RNU7-23P SYT12 ACTN3 CDK2AP2 CLCF1 RBM4
GH11F067604 1.2 ENCODE 6.2 -97.9 -97890 3.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 ENSG00000255119 NUDT8 LRP5 CLCF1 TBC1D10C RHOD NDUFV1 CDK2AP2 C11orf72
GH11F067627 1.2 ENCODE 6.1 -122.6 -122560 8.6 HDGF MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 NUDT8 DOC2GP ENSG00000255119 ENSG00000258297 ENSG00000260808 RAD9A RCE1 CORO1B ANKRD13D CDK2AP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDK2AP2 on UCSC Golden Path with GeneCards custom track

Promoters for CDK2AP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000685652 228 1801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS KLF13

Genomic Location for CDK2AP2 Gene

Chromosome:
11
Start:
67,506,490 bp from pter
End:
67,508,728 bp from pter
Size:
2,239 bases
Orientation:
Minus strand

Genomic View for CDK2AP2 Gene

Genes around CDK2AP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK2AP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK2AP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK2AP2 Gene

Proteins for CDK2AP2 Gene

  • Protein details for CDK2AP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75956-CDKA2_HUMAN
    Recommended name:
    Cyclin-dependent kinase 2-associated protein 2
    Protein Accession:
    O75956

    Protein attributes for CDK2AP2 Gene

    Size:
    126 amino acids
    Molecular mass:
    13101 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDK2AP2 Gene

neXtProt entry for CDK2AP2 Gene

Post-translational modifications for CDK2AP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK2AP2 Gene

No data available for DME Specific Peptides for CDK2AP2 Gene

Domains & Families for CDK2AP2 Gene

Protein Domains for CDK2AP2 Gene

Graphical View of Domain Structure for InterPro Entry

O75956

UniProtKB/Swiss-Prot:

CDKA2_HUMAN :
  • Belongs to the CDK2AP family.
Family:
  • Belongs to the CDK2AP family.
genes like me logo Genes that share domains with CDK2AP2: view

No data available for Gene Families for CDK2AP2 Gene

Function for CDK2AP2 Gene

genes like me logo Genes that share phenotypes with CDK2AP2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK2AP2 Gene

Localization for CDK2AP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK2AP2 gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDK2AP2 Gene

Pathways & Interactions for CDK2AP2 Gene

SuperPathways for CDK2AP2 Gene

No Data Available

Pathways by source for CDK2AP2 Gene

1 GeneTex pathway for CDK2AP2 Gene

Gene Ontology (GO) - Biological Process for CDK2AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CDK2AP2: view

No data available for SIGNOR curated interactions for CDK2AP2 Gene

Transcripts for CDK2AP2 Gene

Unigene Clusters for CDK2AP2 Gene

Cyclin-dependent kinase 2 associated protein 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK2AP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for CDK2AP2 Gene

GeneLoc Exon Structure for
CDK2AP2
ECgene alternative splicing isoforms for
CDK2AP2

Expression for CDK2AP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK2AP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDK2AP2 Gene:

CDK2AP2

SOURCE GeneReport for Unigene cluster for CDK2AP2 Gene:

Hs.523835

mRNA Expression by UniProt/SwissProt for CDK2AP2 Gene:

O75956-CDKA2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with CDK2AP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CDK2AP2 Gene

Orthologs for CDK2AP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDK2AP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK2AP2 34 35
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia CDK2AP2 34 35
  • 94.18 (n)
cow
(Bos Taurus)
Mammalia CDK2AP2 34 35
  • 91.01 (n)
rat
(Rattus norvegicus)
Mammalia Cdk2ap2 34
  • 91.01 (n)
oppossum
(Monodelphis domestica)
Mammalia CDK2AP2 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk2ap2 34 16 35
  • 90.48 (n)
lizard
(Anolis carolinensis)
Reptilia CDK2AP2 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC89864 34
  • 68.61 (n)
Str.6813 34
zebrafish
(Danio rerio)
Actinopterygii cdk2ap2 34 35
  • 69.97 (n)
Dr.9481 34
fruit fly
(Drosophila melanogaster)
Insecta CG18292 35
  • 18 (a)
OneToMany
Species where no ortholog for CDK2AP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDK2AP2 Gene

ENSEMBL:
Gene Tree for CDK2AP2 (if available)
TreeFam:
Gene Tree for CDK2AP2 (if available)

Paralogs for CDK2AP2 Gene

Paralogs for CDK2AP2 Gene

(2) SIMAP similar genes for CDK2AP2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CDK2AP2 Gene

genes like me logo Genes that share paralogs with CDK2AP2: view

Variants for CDK2AP2 Gene

Sequence variations from dbSNP and Humsavar for CDK2AP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1046353 -- 67,506,655(-) CACTT(C/T)TCCCA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1046363 -- 67,506,627(-) TTCTC(C/G)CCCAG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs111372057 -- 67,506,358(+) AGGTC(C/G)CACCA downstream-variant-500B, upstream-variant-2KB
rs111777487 -- 67,506,232(+) GCCCT(C/T)CAGGC downstream-variant-500B, upstream-variant-2KB
rs111887433 -- 67,506,332(+) CGCCA(A/C)GGCTG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDK2AP2 Gene

Variant ID Type Subtype PubMed ID
nsv527056 CNV loss 19592680
nsv521723 CNV loss 19592680
nsv468604 CNV loss 19166990
nsv368 CNV insertion 18451855
esv2422195 CNV duplication 17116639
dgv52n111 CNV deletion 26073780
dgv1977n54 CNV loss 21841781

Variation tolerance for CDK2AP2 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK2AP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK2AP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK2AP2 Gene

Disorders for CDK2AP2 Gene

Relevant External Links for CDK2AP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK2AP2

No disorders were found for CDK2AP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK2AP2 Gene

Publications for CDK2AP2 Gene

  1. Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene. (PMID: 10082655) Zhang X. … Haluska F.G. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Dysregulation of CDK inhibitors and p53 in HPV-negative endocervical adenocarcinoma. (PMID: 25675191) Omori M. … Hirata S. (Int. J. Gynecol. Pathol. 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation. (PMID: 23781148) Liu Q. … Luo Y. (Int. J. Biol. Sci. 2013) 3 64

Products for CDK2AP2 Gene

Sources for CDK2AP2 Gene

Content
Loading form....