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Aliases for CDK2AP2 Gene

Aliases for CDK2AP2 Gene

  • Cyclin Dependent Kinase 2 Associated Protein 2 2 3 5
  • CDK2-Associated Protein 2 2 3 4
  • Tumor Suppressor Deleted In Oral Cancer Related 1 2 3
  • DOC-1-Related Protein 3 4
  • DOC-1R 3 4
  • Cyclin-Dependent Kinase 2-Associated Protein 2 3
  • DOC1R 4
  • P14 3

External Ids for CDK2AP2 Gene

Previous GeneCards Identifiers for CDK2AP2 Gene

  • GC11M067031
  • GC11M067273
  • GC11M063603

Summaries for CDK2AP2 Gene

Entrez Gene Summary for CDK2AP2 Gene

  • This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for CDK2AP2 Gene

CDK2AP2 (Cyclin Dependent Kinase 2 Associated Protein 2) is a Protein Coding gene. An important paralog of this gene is CDK2AP1.

UniProtKB/Swiss-Prot for CDK2AP2 Gene

  • Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK2AP2 Gene

Genomics for CDK2AP2 Gene

Regulatory Elements for CDK2AP2 Gene

Enhancers for CDK2AP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G067503 1.4 ENCODE dbSUPER 7.6 +1.0 1047 7.4 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 CTSF CDK2AP2 PTPRCAP PITPNM1
GH11G067579 1.7 Ensembl ENCODE dbSUPER 6.2 -75.6 -75609 10.2 CREB3L1 MLX ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 ENSG00000255119 NUDT8 PTPRCAP NDUFV1 RBM4B C11orf72 DOC2GP ALDH3B2 CDK2AP2 ACY3
GH11G066891 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +616.1 616137 1.8 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A FEZF1 SLC30A9 ZNF766 FOS ENSG00000254461 RAD9A LRFN4 RBM4B RNU7-23P SYT12 ACTN3 CDK2AP2 CLCF1 RBM4
GH11G067612 1.5 Ensembl ENCODE dbSUPER 6.2 -105.9 -105908 4.1 HDGF PKNOX1 ATF1 ARNT AGO1 WRNIP1 ARID4B SIN3A ZNF48 ZNF2 NUDT8 DOC2GP ANKRD13D RAD9A CDK2AP2 PIR42297
GH11G067604 1.4 ENCODE dbSUPER 6.2 -97.9 -97890 3.6 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC SSRP1 GLIS1 NBN ENSG00000255119 NUDT8 NDUFV1 CDK2AP2 C11orf72
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDK2AP2 on UCSC Golden Path with GeneCards custom track

Promoters for CDK2AP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000264519 328 1201 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1

Genomic Location for CDK2AP2 Gene

Chromosome:
11
Start:
67,506,490 bp from pter
End:
67,508,728 bp from pter
Size:
2,239 bases
Orientation:
Minus strand

Genomic View for CDK2AP2 Gene

Genes around CDK2AP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK2AP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK2AP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK2AP2 Gene

Proteins for CDK2AP2 Gene

  • Protein details for CDK2AP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75956-CDKA2_HUMAN
    Recommended name:
    Cyclin-dependent kinase 2-associated protein 2
    Protein Accession:
    O75956

    Protein attributes for CDK2AP2 Gene

    Size:
    126 amino acids
    Molecular mass:
    13101 Da
    Quaternary structure:
    • Interacts with CDK2AP1 (PubMed:14985111). Interacts with CDK2 (PubMed:23781148). Interacts with MAPK1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for CDK2AP2 Gene

neXtProt entry for CDK2AP2 Gene

Post-translational modifications for CDK2AP2 Gene

Other Protein References for CDK2AP2 Gene

No data available for DME Specific Peptides for CDK2AP2 Gene

Domains & Families for CDK2AP2 Gene

Protein Domains for CDK2AP2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75956

UniProtKB/Swiss-Prot:

CDKA2_HUMAN :
  • Belongs to the CDK2AP family.
Family:
  • Belongs to the CDK2AP family.
genes like me logo Genes that share domains with CDK2AP2: view

No data available for Gene Families for CDK2AP2 Gene

Function for CDK2AP2 Gene

Molecular function for CDK2AP2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148).

Gene Ontology (GO) - Molecular Function for CDK2AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14985111
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CDK2AP2: view
genes like me logo Genes that share phenotypes with CDK2AP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK2AP2 Gene

Localization for CDK2AP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK2AP2 Gene

Cytoplasm. Nucleus. Note=Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules. {ECO:0000250 UniProtKB:Q9CPY4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK2AP2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
extracellular 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CDK2AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005874 microtubule ISS --
genes like me logo Genes that share ontologies with CDK2AP2: view

Pathways & Interactions for CDK2AP2 Gene

SuperPathways for CDK2AP2 Gene

No Data Available

Pathways by source for CDK2AP2 Gene

1 GeneTex pathway for CDK2AP2 Gene

Gene Ontology (GO) - Biological Process for CDK2AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0070507 regulation of microtubule cytoskeleton organization ISS --
GO:2000035 regulation of stem cell division ISS --
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IMP 23781148
genes like me logo Genes that share ontologies with CDK2AP2: view

No data available for SIGNOR curated interactions for CDK2AP2 Gene

Drugs & Compounds for CDK2AP2 Gene

No Compound Related Data Available

Transcripts for CDK2AP2 Gene

Unigene Clusters for CDK2AP2 Gene

Cyclin-dependent kinase 2 associated protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK2AP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for CDK2AP2 Gene

GeneLoc Exon Structure for
CDK2AP2
ECgene alternative splicing isoforms for
CDK2AP2

Expression for CDK2AP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK2AP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDK2AP2 Gene:

CDK2AP2

SOURCE GeneReport for Unigene cluster for CDK2AP2 Gene:

Hs.523835

mRNA Expression by UniProt/SwissProt for CDK2AP2 Gene:

O75956-CDKA2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CDK2AP2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with CDK2AP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK2AP2 Gene

Orthologs for CDK2AP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDK2AP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK2AP2 34 35
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia CDK2AP2 34 35
  • 94.18 (n)
cow
(Bos Taurus)
Mammalia CDK2AP2 34 35
  • 91.01 (n)
rat
(Rattus norvegicus)
Mammalia Cdk2ap2 34
  • 91.01 (n)
oppossum
(Monodelphis domestica)
Mammalia CDK2AP2 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk2ap2 34 16 35
  • 90.48 (n)
lizard
(Anolis carolinensis)
Reptilia CDK2AP2 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC89864 34
  • 68.61 (n)
Str.6813 34
zebrafish
(Danio rerio)
Actinopterygii cdk2ap2 34 35
  • 69.97 (n)
Dr.9481 34
fruit fly
(Drosophila melanogaster)
Insecta CG18292 35
  • 18 (a)
OneToMany
Species where no ortholog for CDK2AP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDK2AP2 Gene

ENSEMBL:
Gene Tree for CDK2AP2 (if available)
TreeFam:
Gene Tree for CDK2AP2 (if available)

Paralogs for CDK2AP2 Gene

Paralogs for CDK2AP2 Gene

(2) SIMAP similar genes for CDK2AP2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CDK2AP2 Gene

genes like me logo Genes that share paralogs with CDK2AP2: view

Variants for CDK2AP2 Gene

Sequence variations from dbSNP and Humsavar for CDK2AP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000237982 -- 67,506,625(+) TGCTG(A/G)GGGAG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001087835 -- 67,508,677(+) CCCGA(A/G)CCCTG upstream-variant-2KB, utr-variant-5-prime
rs1001408108 -- 67,506,914(+) GGATA(C/G)GTCCA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001616827 -- 67,509,056(+) TCTCA(A/C)CTCAG upstream-variant-2KB
rs1002006168 -- 67,507,225(+) TTTCA(A/G)TTCGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDK2AP2 Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
esv2422195 CNV duplication 17116639
nsv368 CNV insertion 18451855
nsv468604 CNV loss 19166990
nsv521723 CNV loss 19592680
nsv527056 CNV loss 19592680

Variation tolerance for CDK2AP2 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK2AP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK2AP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK2AP2 Gene

Disorders for CDK2AP2 Gene

Relevant External Links for CDK2AP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK2AP2

No disorders were found for CDK2AP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK2AP2 Gene

Publications for CDK2AP2 Gene

  1. Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene. (PMID: 10082655) Zhang X. … Haluska F.G. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 64
  2. Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation. (PMID: 23781148) Liu Q. … Luo Y. (Int. J. Biol. Sci. 2013) 3 4 64
  3. Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R). (PMID: 14985111) Buajeeb W. … Wong D.T. (Biochem. Biophys. Res. Commun. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Dysregulation of CDK inhibitors and p53 in HPV-negative endocervical adenocarcinoma. (PMID: 25675191) Omori M. … Hirata S. (Int. J. Gynecol. Pathol. 2015) 3 64

Products for CDK2AP2 Gene

Sources for CDK2AP2 Gene

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