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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK2AP1 Gene

protein-coding   GIFtS: 52
GCID: GC12M123745

cyclin-dependent kinase 2 associated protein 1

(Previous name: CDK2-associated protein 1 )
 Explore 14 diseases affiliated with
CDK2AP1 via our new
 Human Malady Compendium 
Biological research products
for CDK2AP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 2 Associated Protein 11 2     Deleted In Oral Cancer 12 3
DOC11 2 3 5     Putative Oral Cancer Suppressor2 3
CDK2-Associated Protein 11 2 3     Cyclin-Dependent Kinase 2-Associated Protein 12
DORC11 2     Deleted In Oral Cancer-12
ST191 2     CDKAP13
Doc-11     DOC-13
P12DOC-11     

External Ids:    HGNC: 140021   Entrez Gene: 80992   Ensembl: ENSG000001113287   OMIM: 6021985   UniProtKB: O145193   

Export aliases for CDK2AP1 gene to outside databases

Previous GC identifers: GC12P122351 GC12M123446 GC12M123553 GC12M122183 GC12M122270 GC12M120706


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK2AP1:
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to
negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was
found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit,
which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a
core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates
embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation.
Alternative splicing results in multiple transcript variants encoding distinct isoforms. (provided by RefSeq, Jul
2012)

UniProtKB/Swiss-Prot: CDKA1_HUMAN, O14519
Function: specific inhibitor of the cell-cycle kinase CDK2 (By similarity)

Gene Wiki entry for CDK2AP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK2AP1 gene promoter:
         TBP   Tal-1   STAT1beta   Tal-1beta   STAT1alpha   GATA-1   E47   CP2   STAT2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK2AP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK2AP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK2AP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24

CDK2AP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK2AP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M123745:  view genomic region     (about GC identifiers)

Start:
123,745,528 bp from pter      End:
123,756,881 bp from pter
Size:
11,354 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDKA1_HUMAN, O14519 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 2-associated protein 1  
Size: 115 amino acids; 12365 Da
Subunit: Homodimer. Interacts with monomeric unphosphorylated CDK2
1 PDB 3D structure from and Proteopedia for CDK2AP1:
2KW6 (3D)    

Explore the universe of human proteins at neXtProt for CDK2AP1: NX_O14519

Post-translational modifications:

  • Phosphorylated in vitro by IKBKE at Ser-461
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14519

  • CDK2AP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257362.1  NP_001257363.1  NP_004633.1  

    ENSEMBL proteins: 
     ENSP00000261692   ENSP00000442502   ENSP00000442565   ENSP00000440729   ENSP00000438561  
     ENSP00000444499  

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    Novus Biologicals CDK2AP1 Proteins
    Novus Biologicals CDK2AP1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CDK2AP1
    Uscn Proteins for CDK2AP1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9506968
    GO:0005737cytoplasm TAS9506968


    CDK2AP1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CDK2AP1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CDK2AP1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR017266 CDK2-associated_2
     IPR019187 Cyclin-dep_kinase2-assoc_pr

    Graphical View of Domain Structure for InterPro Entry O14519

    ProtoNet protein and cluster: O14519

    UniProtKB/Swiss-Prot: CDKA1_HUMAN, O14519
    Similarity: Belongs to the CDK2AP family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CDKA1_HUMAN, O14519
    Function: specific inhibitor of the cell-cycle kinase CDK2 (By similarity)

    miRNA
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    miRTarBase miRNAs that target CDK2AP1:
    hsa-mir-21 (MIRT005974)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK2AP1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK2AP1 (see all 10):
    hsa-miR-569 hsa-miR-100* hsa-miR-520d-5p hsa-miR-499-3p hsa-miR-3647-3p hsa-miR-1297 hsa-miR-524-5p hsa-miR-26a
    SwitchGear 3'UTR luciferase reporter plasmidCDK2AP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK2AP1 (see all 7)
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9506968


    CDK2AP1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CDK2AP1:
     Decreased viability with cispl  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Cdk2ap1tm1Dtw for CDK2AP1
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdk2ap1):
     cellular  craniofacial  embryogenesis  mortality/aging 

    CDK2AP1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK2AP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/21 Interacting proteins for CDK2AP1 (O145193 ENSP000002616924) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMY1BP047453, ENSP000003304844I2D: score=2 STRING: ENSP00000330484
    AMY1AP047453, ENSP000003591004I2D: score=2 STRING: ENSP00000359100
    AMY1CP047453I2D: score=2 
    CDK2P249413, ENSP000002669704I2D: score=3 STRING: ENSP00000266970
    CDK2AP2O759563, ENSP000003014884I2D: score=3 STRING: ENSP00000301488
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000084S phase of mitotic cell cycle TAS9506968
    GO:0006261DNA-dependent DNA replication TAS9506968
    GO:0006468protein phosphorylation TAS9506968


    CDK2AP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK2AP1
    Search CenterWatch for drugs/clinical trials and news about CDK2AP1 / CDKA1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK2AP1 gene (3 alternative transcripts): 
    NM_001270433.1  NM_001270434.1  NM_004642.3  

    Unigene Cluster for CDK2AP1:

    Cyclin-dependent kinase 2 associated protein 1
    Hs.433201  [show with all ESTs]
    Unigene Representative Sequence: NM_004642
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261692(uc001ueq.3) ENST00000538446 ENST00000535979 ENST00000542174
    ENST00000544658 ENST00000535796

    miRNA
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    hsa-miR-569 hsa-miR-100* hsa-miR-520d-5p hsa-miR-499-3p hsa-miR-3647-3p hsa-miR-1297 hsa-miR-524-5p hsa-miR-26a
    SwitchGear 3'UTR luciferase reporter plasmidCDK2AP1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB006077.1 AF006484.1 BC034717.1 NR_073007.1 NR_073008.1 

    16 DOTS entries:

    DT.449107  DT.92436246  DT.95339946  DT.100670871  DT.75118063  DT.99977522  DT.121108949  DT.86853184 
    DT.92436253  DT.97868471  DT.92436252  DT.99988574  DT.100670872  DT.95309505  DT.97868473  DT.100712004 

    24/371 AceView cDNA sequences (see all 371):

    AA315033 CA868185 BM707824 BM873466 AA479334 D12251 CR616383 CB851770 
    BI335870 AI468749 BM351832 D12258 BM792552 BM782753 AI566873 BM873794 
    BU627933 AA363869 AI681459 AI801399 AA235284 AI040546 AA478600 BG924531 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK2AP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTATTAGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CDK2AP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK2AP1

    SOURCE GeneReport for Unigene cluster: Hs.433201
        SABiosciences Custom PCR Arrays for CDK2AP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK2AP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CDK2AP1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk2ap11 , 5 CDK2 (cyclin-dependent kinase 2)-associated protein more1, 5 87.72(n)1
    98.25(a)1
      5 (63.53 cM)5
    134451  NM_013812.21  NP_038840.21 
     1243454175 
    chicken
    (Gallus gallus)
    Aves CDK2AP11 cyclin-dependent kinase 2 associated protein 1 77.97(n)
    89.57(a)
      416826  NM_001039264.2  NP_001034353.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDK2AP16
    --
    91(a)
    1 ↔ 1
    LGb(1869884-1870853)
    African clawed frog
    (Xenopus laevis)
    Amphibia cdk2ap1-prov2 CDK2-associated protein 1 82.22(n)    BC054285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005352651 cyclin-dependent kinase 2-associated protein 1-like 71.65(n)
    82.76(a)
      100535265  XM_003199397.1  XP_003199445.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG182926
    --
    18(a)
    1 → many
    X(11031915-11033726)


    ENSEMBL Gene Tree for CDK2AP1 (if available)
    TreeFam Gene Tree for CDK2AP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK2AP1 gene
    CDK2AP22  
    2 SIMAP similar genes for CDK2AP1 using alignment to 3 protein entries:     CDKA1_HUMAN (see all proteins):
    DOC-1R    CDK2AP2

    CDK2AP1 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CDK2AP1
    PGOHUM00000248415 PGOHUM00000248579 PGOHUM00000239971 PGOHUM00000237736


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/203 NCBI SNPs in CDK2AP1 are shown (see all 203    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1910512931,2
    --123745017(+) TGTACC/TCTCGT 5 -- ds50010--------
    rs781977351,2
    C,F,--123745149(+) TTCATG/TAGAGA 5 -- ds50013Minor allele frequency- T:0.13WA NA EA 358
    rs1434028521,2
    --123745174(+) ACTTCC/TTTACA 5 -- ds50010--------
    rs19802521,2
    C,F,A,H,--123745178(+) CTTTAG/CACCAG 5 -- ds500115Minor allele frequency- C:0.39NS EA NA CSA WA 807
    rs1812367771,2
    --123745186(+) CAGGCA/GTGGTA 5 -- ds50010--------
    rs1474254481,2
    C,--123745220(+) TTTGA-/GAGGCTAAGGT
    GGAAGGATCACTT
    GAGCC
    5 -- ds50010--------
    rs1378698951,2
    --123745284(+) CTCATC/TTCTGC 5 -- ds50010--------
    rs23379341,2
    C,F,A,H,--123745359(+) CAGGCG/ATAGTG 5 -- ds500119Minor allele frequency- A:0.48NS NA CSA WA EA 1966
    rs1856864181,2
    --123745362(+) GCATAC/GTGGCA 5 -- ds50010--------
    rs66331,2
    C,F,A,H,--123745809(-) AACTTA/C/TTTTTT 10 -- ut31 nc-transcript-varianttrp39MN NA NS WA 643

    HapMap Linkage Disequilibrium report for CDK2AP1 (123745528 - 123756881 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CDK2AP1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK2AP1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDK2AP1 for disorders           About GeneDecksing

    OMIM gene information: 602198    OMIM disorders: --

    14 diseases for CDK2AP1:    About MalaCards
    oral cancer    severe acute respiratory syndrome    squamous cell carcinoma    oral squamous cell carcinoma
    oral leukoplakia    esophageal squamous cell carcinoma    leukoplakia    pneumonia
    esophagitis    gastric cancer    colorectal cancer    carcinoma
    prostate cancer    prostatitis

    2 Novoseek disease relationships for CDK2AP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oral cancer 63.8 3 11555592 (3)
    tumors 18 6 11555592 (2), 10082655 (1), 13679870 (1), 9506968 (1)


    Export disorders for CDK2AP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK2AP1 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with CDK2AP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1. (PubMed id 9506968)1, 2, 3, 9 Tsuji T....Wong D.T. (1998)
    2. Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer. (PubMed id 9331572)1, 2, 3 Daigo Y.... Nakamura Y. (1997)
    3. Human cyclin-dependent kinase 2-associated protein 1 ( CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-t erminal region. (PubMed id 22427660)1, 2 Ertekin A....Montelione G.T. (2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Differential expression of DOC-1 in microsatellite-unstable human colorectal cancer. (PubMed id 13679870)1, 9 Yuan Z....Weber T.K. (2003)
    6. Expression of cyclin-dependent kinase 2-associated pro tein 1 confers an independent prognosticator in nasopharyngeal carcinoma: a coho rt study. (PubMed id 22791769)1 Wu L.C....Shiue Y.L. (2012)
    7. Double edge: CDK2AP1 in cell-cycle regulation and epig enetic regulation. (PubMed id 21865592)1 Wong D.T....Kim Y. (2012)
    8. Human CCAAT/enhancer-binding protein b interacts with chromatin remodeling complexes of the imitation switch subfamily. (PubMed id 22242598)1 Steinberg X.P....Gutierrez J.L. (2012)
    9. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
    10. High I+-defensin and S100A7 expression and missing DOC -1 down-regulation characterize irritation fibromas of the oral cavity and may counteract malignant transformation. (PubMed id 21187770)1 Winter J....Wenghoefer M. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8099 HGNC: 14002 AceView: CDK2AP1 Ensembl:ENSG00000111328 euGenes: HUgn8099
    ECgene: CDK2AP1 H-InvDB: CDK2AP1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for CDK2AP1 Pharmacogenomics, SNPs, Pathways
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