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CDK2AP1 Gene

protein-coding   GIFtS: 52
GCID: GC12M123745

Cyclin-Dependent Kinase 2 Associated Protein 1

(Previous name: CDK2-associated protein 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 2 Associated Protein 11 2     Cyclin-Dependent Kinase 2-Associated Protein 12
CDK2-Associated Protein 11 2 3     Deleted In Oral Cancer-12
DOC12 3 5     doc-12
Deleted In Oral Cancer 12 3     p12DOC-12
Putative Oral Cancer Suppressor2 3     CDKAP13
DORC12     DOC-13
ST192     

External Ids:    HGNC: 140021   Entrez Gene: 80992   Ensembl: ENSG000001113287   OMIM: 6021985   UniProtKB: O145193   

Export aliases for CDK2AP1 gene to outside databases

Previous GC identifers: GC12P122351 GC12M123446 GC12M123553 GC12M122183 GC12M122270 GC12M120706


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK2AP1 Gene:
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to
negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This
protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large
p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This
protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that
epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and
epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
(provided by RefSeq, Jul 2012)

GeneCards Summary for CDK2AP1 Gene:
CDK2AP1 (cyclin-dependent kinase 2 associated protein 1) is a protein-coding gene. Diseases associated with CDK2AP1 include oral cancer, and oral leukoplakia. An important paralog of this gene is CDK2AP2.

UniProtKB/Swiss-Prot: CDKA1_HUMAN, O14519
Function: specific inhibitor of the cell-cycle kinase CDK2 (By similarity)

Gene Wiki entry for CDK2AP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDK2AP1 gene promoter:
         TBP   Tal-1   STAT1beta   Tal-1beta   STAT1alpha   GATA-1   E47   CP2   STAT2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK2AP1 promoter sequence
   Search Chromatin IP Primers for CDK2AP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK2AP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24

CDK2AP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK2AP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M123745:  view genomic region     (about GC identifiers)

Start:
123,745,528 bp from pter      End:
123,756,881 bp from pter
Size:
11,354 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDKA1_HUMAN, O14519 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 2-associated protein 1  
Size: 115 amino acids; 12365 Da
Subunit: Homodimer. Interacts with monomeric unphosphorylated CDK2
1 PDB 3D structure from and Proteopedia for CDK2AP1:
2KW6 (3D)    
Secondary accessions: F5GYA4
Alternative splicing: 2 isoforms:  O14519-1   O14519-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK2AP1: NX_O14519

Explore proteomics data for CDK2AP1 at MOPED

Post-translational modifications: 

  • Phosphorylated in vitro by IKBKE at Ser-461
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CDK2AP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257362.1  NP_001257363.1  NP_004633.1  

    ENSEMBL proteins: 
     ENSP00000261692   ENSP00000442502   ENSP00000442565   ENSP00000440729   ENSP00000438561  
     ENSP00000444499  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017266 CDK2-associated_2
     IPR019187 Cyclin-dep_kinase2-assoc_pr

    Graphical View of Domain Structure for InterPro Entry O14519

    ProtoNet protein and cluster: O14519

    UniProtKB/Swiss-Prot: CDKA1_HUMAN, O14519
    Similarity: Belongs to the CDK2AP family


    CDK2AP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDKA1_HUMAN, O14519
    Function: specific inhibitor of the cell-cycle kinase CDK2 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9506968
         
    CDK2AP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDK2AP1:
     Decreased viability with cispl  Upregulation of Wnt/beta-caten 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdk2ap1):
     cellular  craniofacial  embryogenesis  mortality/aging 

    CDK2AP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdk2ap1tm1Dtw for CDK2AP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK2AP1
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    miRNA
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    miRTarBase miRNAs that target CDK2AP1:
    hsa-mir-21-5p (MIRT005974), hsa-mir-18a-3p (MIRT040895)

    Block miRNA regulation of human, mouse, rat CDK2AP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK2AP1 (see all 10):
    hsa-miR-569 hsa-miR-100* hsa-miR-520d-5p hsa-miR-499-3p hsa-miR-3647-3p hsa-miR-1297 hsa-miR-524-5p hsa-miR-26a
    SwitchGear 3'UTR luciferase reporter plasmidCDK2AP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CDK2AP1
    Predesigned siRNA for gene silencing in human, mouse, rat CDK2AP1

    Gene Editing
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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    mitochondrion3
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9506968
    GO:0005737cytoplasm TAS9506968

    CDK2AP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK2AP1
    Interactions:

        GeneGlobe Interaction Network for CDK2AP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for CDK2AP1 (O145193 ENSP000002616924) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232960P678703, ENSP000003955464I2D: score=1 STRING: ENSP00000395546
    CSNK2BP678703I2D: score=1 
    ENSG00000206406P678703I2D: score=1 
    ENSG00000224398P678703I2D: score=1 
    ENSG00000224774P678703I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000084mitotic S phase TAS9506968
    GO:0006261DNA-dependent DNA replication TAS9506968
    GO:0006468protein phosphorylation TAS9506968

    CDK2AP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDK2AP1 (CDKA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDK2AP1 gene (3 alternative transcripts): 
    NM_001270433.1  NM_001270434.1  NM_004642.3  

    Unigene Cluster for CDK2AP1:

    Cyclin-dependent kinase 2 associated protein 1
    Hs.433201  [show with all ESTs]
    Unigene Representative Sequence: NM_004642
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261692(uc001ueq.3) ENST00000538446 ENST00000535979 ENST00000542174
    ENST00000544658 ENST00000535796
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDK2AP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK2AP1 (see all 10):
    hsa-miR-569 hsa-miR-100* hsa-miR-520d-5p hsa-miR-499-3p hsa-miR-3647-3p hsa-miR-1297 hsa-miR-524-5p hsa-miR-26a
    SwitchGear 3'UTR luciferase reporter plasmidCDK2AP1 3' UTR sequence
    Inhib. RNA
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    OriGene qPCR primer pairs and template standards for CDK2AP1
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      QuantiTect SYBR Green Assays in human, mouse, rat CDK2AP1
      QuantiFast Probe-based Assays in human, mouse, rat CDK2AP1

    Additional mRNA sequence: 

    AB006077.1 AF006484.1 BC034717.1 NR_073007.1 NR_073008.1 

    16 DOTS entries:

    DT.449107  DT.92436246  DT.95339946  DT.100670871  DT.75118063  DT.99977522  DT.121108949  DT.86853184 
    DT.92436253  DT.97868471  DT.92436252  DT.99988574  DT.100670872  DT.95309505  DT.97868473  DT.100712004 

    Selected AceView cDNA sequences (see all 371):

    CR604217 AI742506 F02653 AA235284 BF111493 AA363917 D12271 AF006484 
    BE465797 BE906555 AI680768 AW163326 R46865 AI869836 AI681459 N40173 
    CA414050 CA307044 BG180234 AI566873 AV646354 D12257 BQ229938 D11915 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK2AP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTATTAGTG
    CDK2AP1 Expression
    About this image


    CDK2AP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
    CDK2AP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK2AP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433201
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDK2AP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk2ap11 , 5 CDK2 (cyclin-dependent kinase 2)-associated protein more1, 5 87.72(n)1
    98.25(a)1
      5 (63.53 cM)5
    134451  NM_013812.21  NP_038840.21 
     1243454175 
    chicken
    (Gallus gallus)
    Aves CDK2AP11 cyclin-dependent kinase 2 associated protein 1 77.97(n)
    89.57(a)
      416826  NM_001039264.2  NP_001034353.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDK2AP16
    cyclin-dependent kinase 2 associated protein 1
    91(a)
    1 ↔ 1
    LGb(1869884-1870888)
    African clawed frog
    (Xenopus laevis)
    Amphibia cdk2ap1-prov2 CDK2-associated protein 1 82.22(n)    BC054285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005352651 cyclin-dependent kinase 2-associated protein 1-like 71.65(n)
    82.76(a)
      100535265  XM_003199397.2  XP_003199445.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG182926
    --
    19(a)
    1 → many
    X(11031915-11033726)


    ENSEMBL Gene Tree for CDK2AP1 (if available)
    TreeFam Gene Tree for CDK2AP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK2AP1 gene
    CDK2AP22  
    2 SIMAP similar genes for CDK2AP1 using alignment to 2 protein entries:     CDKA1_HUMAN (see all proteins):
    DOC-1R    CDK2AP2

    CDK2AP1 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CDK2AP1
    PGOHUM00000248415 PGOHUM00000248579 PGOHUM00000239971 PGOHUM00000237736


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK2AP1 (see all 262)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1491743201,2
    --120717941(+) ATTTCA/GAATAA 1 -- us2k10--------
    rs1910512931,2
    --123745017(+) TGTACC/TCTCGT 5 -- ds50010--------
    rs781977351,2
    C,F--123745149(+) TTCATG/TAGAGA 5 -- ds50013Minor allele frequency- T:0.13WA NA EA 358
    rs1434028521,2
    --123745174(+) ACTTCC/TTTACA 5 -- ds50010--------
    rs19802521,2
    C,F,A,H--123745178(+) CTTTAG/CAccag 5 -- ds500115Minor allele frequency- C:0.39NS EA NA CSA WA 807
    rs1812367771,2
    C--123745186(+) CAGGCA/GTGGTA 5 -- ds50010--------
    rs1474254481,2
    C--123745220(+) TTTGA-/GAGGCTAAGGT
    GGAAGGATCACTT
    GAGCC
    5 -- ds50010--------
    rs1378698951,2
    C--123745284(+) CTCATC/TTCTGC 5 -- ds50010--------
    rs23379341,2
    C,F,A,H--123745359(+) CAGGCG/ATAGTG 5 -- ds500119Minor allele frequency- A:0.48NS NA CSA WA EA 1966
    rs1856864181,2
    --123745362(+) GCATAC/GTGGCA 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for CDK2AP1 (123745528 - 123756881 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDK2AP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv826532CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK2AP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK2AP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602198    OMIM disorders: --

    17 diseases for CDK2AP1:    
    About MalaCards
    oral cancer    oral leukoplakia    leukoplakia    oral squamous cell carcinoma
    kaposi's sarcoma    esophageal squamous cell carcinoma    nasopharyngitis    squamous cell carcinoma
    sarcoma    esophagitis    colorectal cancer    lymphoblastic leukemia
    multiple sclerosis    prostate cancer    prostatitis    lung cancer
    leukemia


    CDK2AP1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CDK2AP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oral cancer 63.8 3 11555592 (3)
    tumors 18 6 11555592 (2), 10082655 (1), 13679870 (1), 9506968 (1)


    Export disorders for CDK2AP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK2AP1 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with CDK2AP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1. (PubMed id 9506968)1, 2, 3, 9 Tsuji T.... Wong D.T. (J. Biol. Chem. 1998)
    2. Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer. (PubMed id 9331572)1, 2, 3 Daigo Y.... Nakamura Y. (Genes Chromosomes Cancer 1997)
    3. Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N- terminal region. (PubMed id 22427660)1, 2 Ertekin A.... Montelione G.T. (J. Biol. Chem. 2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Differential expression of DOC-1 in microsatellite-unstable human colorectal cancer. (PubMed id 13679870)1, 9 Yuan Z....Weber T.K. (Oncogene 2003)
    6. Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer. (PubMed id 23404055)1 Sun M....Zhang X. (Int. J. Oncol. 2013)
    7. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    8. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PubMed id 24144296)1 Cheng C.Y....Baird P.N. (Am. J. Hum. Genet. 2013)
    9. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    10. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8099 HGNC: 14002 AceView: CDK2AP1 Ensembl:ENSG00000111328 euGenes: HUgn8099
    ECgene: CDK2AP1 H-InvDB: CDK2AP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDK2AP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK2AP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK2AP1 gene:
    Search GeneIP for patents involving CDK2AP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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