Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

CDK20 Gene

protein-coding GIFtS: 51
GCID: GC09M090582

Cyclin-Dependent Kinase 20

(Previous name: cell cycle related kinase)
(Previous symbol: CCRK)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cyclin-Dependent Kinase 20¹ ²		CAK-Kinase P42² ³
CCRK¹ ² ³ ⁵		CDK-Activating Kinase P42² ³
CDCH² ³ ⁵		EC 2.7.11.22³ ⁸
Cell Cycle-Related Kinase² ³		P42² ⁵
Cell Division Protein Kinase 20² ³		Cell Cycle Related Kinase¹
Cyclin-Dependent Protein Kinase H² ³		PNQALRE²
Cyclin-Kinase-Activating Kinase P42² ³		EC 2.7.11⁸

External Ids:	HGNC: 21420¹	Entrez Gene: 23552²	Ensembl: ENSG00000156345⁷	OMIM: 610076⁵	UniProtKB: Q8IZL9³

Export aliases for CDK20 gene to outside databases

Previous GC identifers: GC09M089772 GC09M060404

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CDK20 Gene:

The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein

kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively

spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Dec 2009)

GeneCards Summary for CDK20 Gene:

CDK20 (cyclin-dependent kinase 20) is a protein-coding gene. Diseases associated with CDK20 include mantle cell lymphoma, and retinoblastoma. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDKL1.

UniProtKB/Swiss-Prot: CDK20_HUMAN, Q8IZL9

Function: Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the

structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be

properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a

kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000009.12 NT_008470.20 NC_018920.2

Regulatory elements:

Search for regulatory transcription factor binding sites for CDK20
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDK20 promoter sequence

Search Chromatin IP Primers for CDK20

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1 Ensembl cytogenetic band: 9q22.1 HGNC cytogenetic band: 9q22.1

CDK20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK20 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M090582: view genomic region (about GC identifiers)

Start:	90,581,356 bp from pter	End:	90,589,695 bp from pter
Size:	8,340 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CDK20_HUMAN, Q8IZL9 (See protein sequence)

Recommended Name: Cyclin-dependent kinase 20

Size: 346 amino acids; 38695 Da

Subunit: Monomer. Interacts with TBC1D32 (By similarity). Interacts with MAK

Sequence caution: Sequence=AAC98920.1; Type=Frameshift; Positions=331; Sequence=CAH72843.1; Type=Erroneous gene

model prediction;

Secondary accessions: A2A389 A2A390 B4DQX1 O95137 Q5EDC4 Q5VYW1 Q9BUF4

Alternative splicing: 5 isoforms: Q8IZL9-1 Q8IZL9-2 Q8IZL9-3 Q8IZL9-4 Q8IZL9-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK20: NX_Q8IZL9

Explore proteomics data for CDK20 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for CDK20 (Q8IZL9) (see all 5)

VHRDLKP

IVHRDLK

VGCIMGE

PLEEVLPD

See CDK20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (5 alternative transcripts):

NP_001034892.1 NP_001164110.1 NP_001164111.1 NP_036251.2 NP_848519.1

ENSEMBL proteins:

ENSP00000338975 ENSP00000365043 ENSP00000365031 ENSP00000474485 ENSP00000322343

CDK20 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins for CDK20 OriGene Protein Over-expression Lysate for CDK20 OriGene Custom MassSpec OriGene Custom Protein Services for CDK20
	GenScript Custom Purified and Recombinant Proteins Services for CDK20
	Novus Biologicals CDK20 Proteins Novus Biologicals CDK20 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for CDK20

CDK20 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for CDK20 OriGene Custom Antibody Services for CDK20
	Novus Biologicals CDK20 Antibodies
	Search for Antibodies for CDK20 at Abcam
	Cloud-Clone Corp. Antibodies for CDK20
	ThermoFisher Antibodies for CDK20
	LSBio Antibodies in human, mouse, rat for CDK20

CDK20 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CDK20
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CDK20
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for CDK20 Cloud-Clone Corp. CLIAs for CDK20

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

CDK: Cyclin-dependent kinases

IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 20

CCRK subfamily

5 InterPro protein domains:

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_dom

Graphical View of Domain Structure for InterPro Entry Q8IZL9

ProtoNet protein and cluster: Q8IZL9

UniProtKB/Swiss-Prot: CDK20_HUMAN, Q8IZL9

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily

Similarity: Contains 1 protein kinase domain

CDK20 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: CDK20_HUMAN, Q8IZL9

Function: Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the

structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be

properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a

kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB): EC 2.7.11.22¹ ² EC 2.7.11²

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	--	--
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IEA	--
GO:0004713	protein tyrosine kinase activity	--	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--

CDK20 for ontologies About GeneDecksing

Phenotypes:
7 GenomeRNAi human phenotypes for CDK20:

Decreased Salmonella enterica	Decreased focal adhesion (FA)	Decreased substrate adherent c	Decreased telomerase activity
Decreased viability of wild-ty	Increased apoptosis	Upregulation of Wnt/beta-caten

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK20

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK20

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK20

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK20

miRNA Products:		miRTarBase miRNAs that target CDK20: hsa-mir-615-3p (MIRT039839), hsa-mir-335-5p (MIRT017181)

		Block miRNA regulation of human, mouse, rat CDK20 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate CDK20:
		hsa-miR-4251
		SwitchGear 3'UTR luciferase reporter plasmid: CDK20 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CDK20
		Predesigned siRNA for gene silencing in human, mouse, rat CDK20

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CDK20

Clone Products:		OriGene clones in human, mouse for CDK20 (see all 30) OriGene ORF clones in mouse, rat for CDK20 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): CDK20 (NM_178432)
		Sino Biological Human cDNA Clone for CDK20
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK20
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK20

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDK20
		Browse ESI BIO Cell Lines and PureStem Progenitors for CDK20

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK20

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

CDK20_HUMAN, Q8IZL9: Nucleus. Cytoplasm (By similarity). Cell projection, cilium (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	2
cytoskeleton	1
mitochondrion	1

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005929	cilium	IEA	--

CDK20 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for CDK20
Interactions:

Search GeneGlobe Interaction Network for CDK20

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CDK20 (ENSP00000322343⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCNH	ENSP00000256897⁴	STRING: ENSP00000256897
CDK2	ENSP00000266970⁴	STRING: ENSP00000266970
CSNK2B	ENSP00000365025⁴	STRING: ENSP00000365025
GTF2IRD1	ENSP00000265755⁴	STRING: ENSP00000265755
MAK	ENSP00000313021⁴	STRING: ENSP00000313021

About this table

Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	--	--
GO:0007275	multicellular organismal development	IEA	--
GO:0051301	cell division	IEA	--

CDK20 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CDK20

2 HMDB Compounds for CDK20 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

Selected Novoseek inferred chemical compound relationships for CDK20 gene (see all 12) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
flavopiridol	61.5	1	10368639 (1)
pd 98,059	44.6	2	19154444 (1)
tyrosine	41.8	23	1692963 (5), 7722327 (3), 9748296 (2), 1879344 (2) (see all 10)
okadaic acid	34.1	1	8389730 (1)
threonine	33.2	1	1655537 (1)
flavonoid	21.3	1	8610110 (1)
wortmannin	17.8	1	12414747 (1)
calcium	0	2	18649271 (1), 10732121 (1)
phosphatidylinositol	0	2	8395016 (1), 9748296 (1)
glutamate	0	2	9178950 (1)

CDK20 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for CDK20 gene (5 alternative transcripts):

NM_001039803.2 NM_001170639.1 NM_001170640.1 NM_012119.4 NM_178432.3

Unigene Cluster for CDK20:

Cyclin-dependent kinase 20

Hs.522274 [show with all ESTs]

Unigene Representative Sequence: AF113130

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000459720 ENST00000603475 ENST00000336654 ENST00000375883(uc004apr.3 uc004aps.3 uc022bjj.1 uc004apt.3)

ENST00000375871(uc004apu.3) ENST00000605159 ENST00000325303 ENST00000486228

ENST00000604175 ENST00000605591

miRNA Products:		Block miRNA regulation of human, mouse, rat CDK20 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate CDK20:
		hsa-miR-4251
		SwitchGear 3'UTR luciferase reporter plasmid: CDK20 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CDK20
		Predesigned siRNA for gene silencing in human, mouse, rat CDK20

Clone Products:		OriGene clones in human, mouse for CDK20 (see all 30) OriGene ORF clones in mouse, rat for CDK20 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): CDK20 (NM_178432)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK20
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK20

Primer Products:		OriGene qPCR primer pairs and template standards for CDK20 OriGene qSTAR qPCR primer pairs in human, mouse for CDK20
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CDK20
		QuantiTect SYBR Green Assays in human, mouse, rat CDK20
		QuantiFast Probe-based Assays in human, mouse, rat CDK20

Additional mRNA sequence:

AF035013.1 AF113130.1 AK075325.1 AK298993.1 AY904367.1 BC002655.2

7 DOTS entries:

DT.101982509 DT.92426077 DT.95372023 DT.111029 DT.100793518 DT.92426079 DT.100793519

Selected AceView cDNA sequences (see all 94):

AA156950 NM_012119 CR607702 AI479563 BF056145 BF112052 NM_178432 CA489134

AV706756 AF035013 BM982394 CB992644 BE221274 BI757318 BI461940 BI772502

AW005816 AA319839 BI459329 BE467048 N59289 BX091841 BV199036 BX344376

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK20 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	·	8d
SP1:															-								-
SP2:																							-
SP3:															-								-								-
SP4:															-
SP5:															-								-		-		-

ECgene alternative splicing isoforms for CDK20

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

CDK20 expression in normal human tissues (normalized intensities) CDK20 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAAGGAAGTG

About this image

CDK20 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 6) fully expand


Ovary (Reproductive System) fully expand to see all 2 entries
Oviduct
Secondary follicles

Brain (Nervous System) fully expand to see all 2 entries
Hippocampus

Testis (Reproductive System)
Leydig Cells Testis Interstitium

Heart (Cardiovascular System)
Endocardial Tube Cells Endocardium

Pancreas (Endocrine System)
Islets of Langerhans

CDK20 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CDK20 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.522274

Custom PCR Arrays for CDK20

Primer Products:		OriGene qPCR primer pairs and template standards for CDK20 OriGene qSTAR qPCR primer pairs in human, mouse for CDK20
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CDK20
		QuantiTect SYBR Green Assays in human, mouse, rat CDK20
		QuantiFast Probe-based Assays in human, mouse, rat CDK20

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK20

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK20 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdk20^{1 , 5}	cyclin-dependent kinase 20^{1, 5}	87.96(n)¹ 94.22(a)¹		13 (33.26 cM)⁵ 105278¹ NM_053180.2¹ NP_444410.1¹ 64432553⁵
lizard (Anolis carolinensis)	Reptilia	CDK20⁶	cyclin-dependent kinase 20	74(a)	1 ↔ 1	2(86265723-86278000)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.7508²	Transcribed sequence with weak similarity to protein pirS23382 (H.sapiens) S23382 protein kinase (EC 2.7.1.37) cdk3 - human less	75.48(n)		CF345571.1
zebrafish (Danio rerio)	Actinopterygii	cdk20¹	cyclin-dependent kinase 20	68.5(n) 74.02(a)		494112 NM_001008655.1 NP_001008655.1
fruit fly (Drosophila melanogaster)	Insecta	CG6800¹	CG6800	53.52(n) 43.73(a)		42562 NM_142727.1 NP_650984.1
worm (Caenorhabditis elegans)	Secernentea	dyf-18⁶	Protein DYF-18 (dyf-18) mRNA, complete cds	32(a)	1 → many	IV(11798665-11801088) WBGene00010349
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	KIN28⁶	Serine/threonine protein kinase, subunit of the tr...	37(a)	1 → many	IV(267698-268699) YDL108W

ENSEMBL Gene Tree for CDK20 (if available)
TreeFam Gene Tree for CDK20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for CDK20 gene

CDKL1² CDKL2² CDKL5² CDKL3² CDK7² CDKL4²

Selected SIMAP similar genes for CDK20 using alignment to 1 protein entry: CDK20_HUMAN(see all similar genes):

CCRK CDK1 CDC2 CDK3 DKFZp686L20222 CDK17

MAPK7 CDK7 CDC2L1 CDC2L2 CDK11A CDK11B

CDK18 CDK5 PCTK3 CDK16 CDK12 CDK15

CDK20 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192286561^1,2	C	--	90582340(+)	`AGTGGA/TCCTGA`	5	--	ut3¹		0	--	--	--	--
rs144686198^1,2	C,F	--	90582380(+)	`TCTCAC/TCCCTC`	8	G	syn¹ ut3¹		1		NA	3134
rs200903388^1,2	C	--	90582383(+)	`CACCCC/TTCCAG`	8	E	syn¹ ut3¹		0	--	--	--	--
rs56736734^1,2	C,F	--	90582445(+)	`GTCCAA/C/TGTGGA`	13	M V L	mis¹ ut3¹		1		NA	3114
rs151084868^1,2	C	--	90582463(+)	`GATGTG/CGGGGG`	8	/H /D	mis¹ ut3¹		1		NA	2906
rs141370831^1,2	C,F	--	90582470(+)	`GGGGGC/GCCTGG`	8	G	syn¹ ut3¹		1		NA	2862
rs4350071^1,2	C,H	--	90582577(+)	`AGCCTG/CAGGGT`	5	--	int¹		4		NS EA	372
rs369111668^1,2	C	--	90582614(+)	`CTAGTC/GACCTC`	5	--	int¹		0	--	--	--	--
rs149446030^1,2		--	90582698(+)	`AGTGTC/GTACTA`	5	--	int¹		0	--	--	--	--
rs143033261^1,2	C	--	90582703(+)	`CTACTA/GTGTCT`	5	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDK20 (90581356 - 90589695 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for CDK20: --

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CDK20

DNA2.0 Custom Variant and Variant Library Synthesis for CDK20

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 610076 OMIM disorders: --

17 diseases for CDK20: About MalaCards

mantle cell lymphoma retinoblastoma fanconi's anemia lymphoblastic leukemia

medulloblastoma hypoxia prostate cancer pancreatic cancer

prostatitis pancreatitis colorectal cancer thyroiditis

malaria leukemia endotheliitis neuronitis

breast cancer

CDK20 for disorders About GeneDecksing

4 Novoseek inferred disease relationships for CDK20 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	37.5	2	8021495 (1), 11961048 (1)
tumors	14.5	7	17565152 (1), 11961048 (1), 17439397 (1), 19672860 (1)
cancer	7.69	7	15347600 (2), 15801830 (1), 15857291 (1), 17208431 (1) (see all 6)
prostate cancer	0	2	17531530 (2)

Genetic Association Database (GAD): CDK20

Export disorders for CDK20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for CDK20 gene, integrated from 10 sources (see all 117):
(articles sorted by number of sources associating them with CDK20)

Utopia: connect your pdf to the dynamic
world of online information

p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. (PubMed id 14597612)^{1, 2, 9} Liu Y.... Galaktionov K. (J. Biol. Chem. 2004)
Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/C(CDH1). (PubMed id 21986944)^{1, 2} Wang L.Y. and Kung H.J. (Oncogene 2012)
Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)^{1, 3} Malumbres M....Wolgemuth D.J. (Nat. Cell Biol. 2009)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (Nature 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. (PubMed id 19672860)^{1, 9} Wu G.Q....Kung H.F. (Int. J. Cancer 2009)
Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. (PubMed id 16954377)^{1, 9} Fu Z....Sturgill T.W. (Mol. Cell. Biol. 2006)
CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner. (PubMed id 23743448)¹ Yang Y....MAokelAo T.P. (EMBO Rep. 2013)
The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)¹ Varjosalo M....Gstaiger M. (Cell Rep 2013)
Functional genomics identifies drivers of medulloblastoma dissemination. (PubMed id 22875024)¹ Mumert M....Fults D.W. (Cancer Res. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 23552	HGNC: 21420	AceView: CCRK	Ensembl:ENSG00000156345	euGenes: HUgn23552
ECgene: CDK20	H-InvDB: CDK20

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for CDK20	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDK20	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ccrk/

Intellectual Property for CDK20 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for CDK20 gene:
Search GeneIP for patents involving CDK20

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for CDK20		OriGene RNAi products in human, mouse, rat for CDK20
	OriGene qPCR primer pairs and template standards for CDK20		OriGene Protein Over-expression Lysate for CDK20
	OriGene Custom Mass Spec		OriGene clones in human, mouse for CDK20
	OriGene qSTAR qPCR primer pairs in human, mouse for CDK20		OriGene Purified Protein for CDK20
	OriGene ORF clones in mouse, rat for CDK20		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CDK20		OriGene Custom Protein Services for CDK20

	Block miRNA regulation of human, mouse, rat CDK20 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing CDK20
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK20		Predesigned siRNA for gene silencing in human, mouse, rat CDK20
	QuantiFast Probe-based Assays in human, mouse, rat CDK20		QuantiTect SYBR Green Assays in human, mouse, rat CDK20
	Custom PCR Arrays for CDK20		Search Chromatin IP Primers for CDK20
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat CDK20		Search GeneGlobe Interaction Network for CDK20
	Search Regulatory tfbs for CDK20

	GenScript Custom Purified and Recombinant Proteins Services for CDK20		GenScript cDNA clones with any tag delivered in your preferred vector for CDK20
	GenScript Custom Assay Services for CDK20		GenScript Custom overexpressing Cell Line Services for CDK20
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for CDK20

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	cDNA Clones for CDK20
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CDK20 antibodies
	CDK20 proteins
	CDK20 lysates

	Search for Antibodies for CDK20 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CDK20
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for CDK20
	Antibodies for CDK20
	ELISAs for CDK20
	CLIAs for CDK20

Browse ESI BIO Cell Lines and PureStem Progenitors for CDK20

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK20

	SwitchGear 3'UTR luciferase reporter plasmids for CDK20
	SwitchGear Promoter luciferase reporter plasmids for CDK20

ThermoFisher Antibodies for CDK20

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK20

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK20
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK20

LSBio Antibodies in human, mouse, rat for CDK20

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CDK20 gene at Home site.

Version: 3.12.136 22 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

CDK20 Gene

Cyclin-Dependent Kinase 20

Aliases
for CDK20 gene

Summaries
for CDK20 gene

Genomic Views
for CDK20 gene

Proteins
for CDK20 gene

CDK20 Human Recombinant Protein Products:

CDK20 Antibody Products:

CDK20 Assay Products:

Domains /
Families
for CDK20 gene

Function
for CDK20 gene

Localization
for CDK20 gene

Pathways & Interactions
for CDK20 gene

Drugs & Compounds
for CDK20 gene

Transcripts
for CDK20 gene

Expression
for CDK20 gene

Orthologs
for CDK20 gene

Paralogs
for CDK20 gene

Genomic Variants
for CDK20 gene

Disorders / Diseases
for CDK20 gene

Publications
for CDK20 gene

External Searches for CDK20 gene

Genome Databases showing CDK20 gene

Other Databases showing CDK20 gene

Specialized Databases showing CDK20 gene

Intellectual Property
for CDK20 gene

Products
for CDK20 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

CDK20 Gene

Cyclin-Dependent Kinase 20

Aliasesfor CDK20 gene

Summariesfor CDK20 gene

Genomic Viewsfor CDK20 gene

Proteinsfor CDK20 gene

CDK20 Human Recombinant Protein Products:

CDK20 Antibody Products:

CDK20 Assay Products:

Domains /Familiesfor CDK20 gene

Functionfor CDK20 gene

Localizationfor CDK20 gene

Pathways & Interactionsfor CDK20 gene

Drugs & Compoundsfor CDK20 gene

Transcriptsfor CDK20 gene

Expression for CDK20 gene

Orthologsfor CDK20 gene

Paralogsfor CDK20 gene

Genomic Variantsfor CDK20 gene

Disorders / Diseasesfor CDK20 gene

Publicationsfor CDK20 gene

External Searches for CDK20 gene

Genome Databases showing CDK20 gene

Other Databases showing CDK20 gene

Specialized Databases showing CDK20 gene

Intellectual Propertyfor CDK20 gene

Productsfor CDK20 gene

View Random Gene

Aliases
for CDK20 gene

Summaries
for CDK20 gene

Genomic Views
for CDK20 gene

Proteins
for CDK20 gene

Domains /
Families
for CDK20 gene

Function
for CDK20 gene

Localization
for CDK20 gene

Pathways & Interactions
for CDK20 gene

Drugs & Compounds
for CDK20 gene

Transcripts
for CDK20 gene

Expression
for CDK20 gene

Orthologs
for CDK20 gene

Paralogs
for CDK20 gene

Genomic Variants
for CDK20 gene

Disorders / Diseases
for CDK20 gene

Publications
for CDK20 gene

Intellectual Property
for CDK20 gene

Products
for CDK20 gene