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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK20 Gene

protein-coding   GIFtS: 52
GCID: GC09M090582

Cyclin-Dependent Kinase 20

(Previous name: cell cycle related kinase)
(Previous symbol: CCRK)
  18 related diseases
at
MalaCards
 

Aliases
for CDK20 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase 201 2     CAK-Kinase P422 3
CCRK1 2 3 5     CDK-Activating Kinase P422 3
CDCH2 3 5     EC 2.7.11.223 8
Cell Cycle-Related Kinase2 3     P422 5
Cell Division Protein Kinase 202 3     Cell Cycle Related Kinase1
Cyclin-Dependent Protein Kinase H2 3     PNQALRE2
Cyclin-Kinase-Activating Kinase P422 3     EC 2.7.118

External Ids:    HGNC: 214201   Entrez Gene: 235522   Ensembl: ENSG000001563457   OMIM: 6100765   UniProtKB: Q8IZL93   

Export aliases for CDK20 gene to outside databases

Previous GC identifers: GC09M089772 GC09M060404


Summaries
for CDK20 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDK20 Gene:
The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein
kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively
spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Dec 2009)

GeneCards Summary for CDK20 Gene: 
CDK20 (cyclin-dependent kinase 20) is a protein-coding gene. Diseases associated with CDK20 include mantle cell lymphoma, and fanconi's anemia. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is CDK11A.

UniProtKB/Swiss-Prot: CDK20_HUMAN, Q8IZL9
Function: Required for high-level Shh responses in the developing neural tube. Together with BROMI, controls the
structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be
properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a
kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'




Genomic Views
for CDK20 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK20
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDK20 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1   Ensembl cytogenetic band:  9q22.1   HGNC cytogenetic band: 9q22.1

CDK20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK20 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M090582:  view genomic region     (about GC identifiers)

Start:
 90,581,356 bp from pter      End:
 90,589,695 bp from pter
Size:
 8,340 bases      Orientation:
 minus strand

Proteins
for CDK20 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: CDK20_HUMAN, Q8IZL9 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 20  
Size: 346 amino acids; 38695 Da
Subunit: Monomer. Interacts with BROMI (By similarity). Interacts with MAK
Subcellular location: Nucleus. Cytoplasm (By similarity). Cell projection, cilium (By similarity)
Sequence caution: Sequence=AAC98920.1; Type=Frameshift; Positions=331; Sequence=CAH72843.1; Type=Erroneous gene
model prediction;
Secondary accessions: A2A389 A2A390 B4DQX1 O95137 Q5EDC4 Q5VYW1 Q9BUF4
Alternative splicing: 5 isoforms:  Q8IZL9-1   Q8IZL9-2   Q8IZL9-3   Q8IZL9-4   Q8IZL9-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK20: NX_Q8IZL9

Explore proteomics data for CDK20 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZL9

    • 4/5 DME Specific Peptides for CDK20 (Q8IZL9) (see all 5)
     VHRDLKP  IVHRDLK  VGCIMGE  PLEEVLPD 

    CDK20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK20 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001034892.1  NP_001164110.1  NP_001164111.1  NP_036251.2  NP_848519.1  

    ENSEMBL proteins: 
     ENSP00000338975   ENSP00000365043   ENSP00000365031   ENSP00000474485   ENSP00000322343  

    Human Recombinant Protein Products for CDK20: 
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    OriGene Protein Over-expression Lysate for CDK20
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    Novus Biologicals CDK20 Proteins
    Novus Biologicals CDK20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK20 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005929cilium IEA--

    CDK20 for ontologies           About GeneDecksing



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    Assay Products for CDK20: 
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    Cloud-Clone Corp. ELISAs for CDK20 
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    Protein Domains /
    Families
    for CDK20 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 20 
    CCRK subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8IZL9

    ProtoNet protein and cluster: Q8IZL9

    UniProtKB/Swiss-Prot: CDK20_HUMAN, Q8IZL9
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK20 for domains           About GeneDecksing


    Function
    for CDK20 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK20_HUMAN, Q8IZL9
    Function: Required for high-level Shh responses in the developing neural tube. Together with BROMI, controls the
    structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be
    properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a
    kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    CDK20 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for CDK20:
     Decreased Salmonella enterica   Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased telomerase activity 
     Decreased viability of wild-ty  Increased apoptosis  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK20 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK20 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK20 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CDK20:
    hsa-miR-4251
    SwitchGear 3'UTR luciferase reporter plasmid: CDK20 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CDK20

    Clone
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    Sino Biological Human cDNA Clone for CDK20
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK20
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                         Customized lentivirus expression plasmids for stable overexpression of CDK20 

    Cell Line
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    Search LifeMap BioReagents cell lines for CDK20
    In Situ Assay
    Products:       
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    Pathways & Interactions
    for CDK20 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for CDK20 (ENSP000003223434) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNHENSP000002568974STRING: ENSP00000256897
    CDK2ENSP000002669704STRING: ENSP00000266970
    CSNK2BENSP000003650254STRING: ENSP00000365025
    GTF2IRD1ENSP000002657554STRING: ENSP00000265755
    MAKENSP000003130214STRING: ENSP00000313021
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007275multicellular organismal development IEA--
    GO:0051301cell division IEA--

    CDK20 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK20 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK20 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK20

    2 HMDB Compounds for CDK20    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10/12 Novoseek inferred chemical compound relationships for CDK20 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavopiridol 61.5 1 10368639 (1)
    pd 98,059 44.6 2 19154444 (1)
    tyrosine 41.8 23 1692963 (5), 7722327 (3), 9748296 (2), 1879344 (2) (see all 10)
    okadaic acid 34.1 1 8389730 (1)
    threonine 33.2 1 1655537 (1)
    flavonoid 21.3 1 8610110 (1)
    wortmannin 17.8 1 12414747 (1)
    calcium 0 2 18649271 (1), 10732121 (1)
    phosphatidylinositol 0 2 8395016 (1), 9748296 (1)
    glutamate 0 2 9178950 (1)

    Search CenterWatch for drugs/clinical trials and news about CDK20

    Transcripts
    for CDK20 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDK20 gene (5 alternative transcripts): 
    NM_001039803.2  NM_001170639.1  NM_001170640.1  NM_012119.4  NM_178432.3  

    Unigene Cluster for CDK20:

    Cyclin-dependent kinase 20
    Hs.522274  [show with all ESTs]
    Unigene Representative Sequence: AF113130
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000459720 ENST00000603475 ENST00000336654 ENST00000375883(uc004apr.3 uc004aps.3 uc022bjj.1 uc004apt.3)
    ENST00000375871(uc004apu.3) ENST00000605159 ENST00000325303 ENST00000486228
    ENST00000604175 ENST00000605591
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CDK20:
    hsa-miR-4251
    SwitchGear 3'UTR luciferase reporter plasmid: CDK20 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CDK20
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK20
    Clone
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    OriGene ORF clones in mouse, rat for CDK20
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                         Customized lentivirus expression plasmids for stable overexpression of CDK20 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK20
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK20

    Additional mRNA sequence: 

    AF035013.1 AF113130.1 AK075325.1 AK298993.1 AY904367.1 BC002655.2 

    7 DOTS entries:

    DT.101982509  DT.92426077  DT.95372023  DT.111029  DT.100793518  DT.92426079  DT.100793519 

    24/94 AceView cDNA sequences (see all 94):

    BF056145 CR607702 NM_012119 AA156950 AI479563 NM_178432 BF112052 AV706756 
    CA489134 AL602947 AI458554 BI459329 BE467048 AW772529 CB306598 BX344377 
    AA319839 CD556471 CD357898 AI078826 AX810715 AW207510 AW005816 CD366011 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDK20 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:                                            -                       -                                             
    SP2:                                                                    -                                             
    SP3:                                            -                       -                       -                     
    SP4:                                            -                                                                     
    SP5:                                            -                       -     -     -                                 


    ECgene alternative splicing isoforms for CDK20

    Expression
    for CDK20 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK20 expression in normal human tissues (normalized intensities)      CDK20 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGAAGTG
    CDK20 Expression
    About this image


    CDK20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Secondary follicles
             oocyte   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Blood (Hematopoietic System)
             bone marrow-derived macrophages   
     
     Testis (Reproductive System)

    See CDK20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK20

    SOURCE GeneReport for Unigene cluster: Hs.522274
        SABiosciences Custom PCR Arrays for CDK20
    Primer
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    In Situ
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    Orthologs
    for CDK20 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK20 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cdk201 , 5 cyclin-dependent kinase 201, 5 87.96(n)1
    94.22(a)1    		   13 (33.26 cM)5
    1052781  NM_053180.21  NP_444410.11 
     644325535 
    chicken
    (Gallus gallus)    		 Aves CDK206
    		 cyclin-dependent kinase 20
    		 48(a)
    		 1 ↔ 1
    		 AADN03022286.1(21-1405)
    lizard
    (Anolis carolinensis)    		 Reptilia CDK206
    		 Uncharacterized protein
    		 73(a)
    		 1 ↔ 1
    		 2(86265723-86278000)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.75082 Transcribed sequence with weak similarity to protein pirS23382 (H.sapiens) S23382 protein kinase (EC 2.7.1.37) cdk3 - human less 75.48(n)    CF345571.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cdk201 cyclin-dependent kinase 20 68.5(n)
    74.02(a)    		   494112  NM_001008655.1  NP_001008655.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG68001 CDK7-like 53.6(n)
    43.88(a)    		   42562  NM_142727.1  NP_650984.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea dyf-186
    F52B5.26
    		 Protein F52B5.2
    		 29(a)
    23(a)
    		 1 ↔ many
    1 ↔ many
    		 IV(11798665-11801088)
    I(8315902-8318252)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes KIN286
    		 Serine/threonine protein kinase, subunit of the tr...
    		 37(a)
    		 1 → many
    		 IV(267698-268699)


    ENSEMBL Gene Tree for CDK20 (if available)
    TreeFam Gene Tree for CDK20 (if available)

    Paralogs
    for CDK20 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK20 gene
    CDK11A2  CDK102  CDK11B2  CDK72  
    18/47 SIMAP similar genes for CDK20 using alignment to 1 protein entry:     CDK20_HUMAN(see all similar genes):
    CCRK    CDK1    CDC2    CDK3    DKFZp686L20222    CDK17
    MAPK7    CDK7    CDC2L1    CDC2L2    CDK11A    CDK11B
    CDK18    CDK5    PCTK3    CDK16    CDK12    CDK15

    CDK20 for paralogs           About GeneDecksing



    Genomic Variants
    for CDK20 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/300 SNPs in CDK20 are shown (see all 300)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1922865611,2
    		C--90582340(+) AGTGGA/TCCTGA 5 -- ut310--------
    rs1446861981,2
    		C,F--90582380(+) TCTCAC/TCCCTC 8 G syn1 ut311Minor allele frequency- T:0.00NA 3134
    rs2009033881,2
    		C--90582383(+) CACCCC/TTCCAG 8 E syn1 ut310--------
    rs567367341,2
    		C,F--90582445(+) GTCCAA/C/TGTGGA 13 M V L mis1 ut311NA 3114
    rs1510848681,2
    		C--90582463(+) GATGTG/CGGGGG 8 /H /D mis1 ut311Minor allele frequency- C:0.00NA 2906
    rs1413708311,2
    		C,F--90582470(+) GGGGGC/GCCTGG 8 G syn1 ut311Minor allele frequency- G:0.00NA 2862
    rs43500711,2
    		C,H--90582577(+) AGCCTG/CAGGGT 5 -- int14Minor allele frequency- C:0.00NS EA 372
    rs3691116681,2
    		C--90582614(+) CTAGTC/GACCTC 5 -- int10--------
    rs1494460301,2
    		--90582698(+) AGTGTC/GTACTA 5 -- int10--------
    rs1430332611,2
    		C--90582703(+) CTACTA/GTGTCT 5 -- int10--------

    HapMap Linkage Disequilibrium report for CDK20 (90581356 - 90589695 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CDK20: --
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK20
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK20

    Disorders / Diseases
    for CDK20 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 610076    OMIM disorders: --

    18 diseases for CDK20:    About MalaCards
    mantle cell lymphoma    fanconi's anemia    acute lymphoblastic leukemia    lymphoblastic leukemia
    retinoblastoma    anemia    prostate cancer    hypoxia
    glioblastoma    pancreatic cancer    thyroiditis    prostatitis
    colorectal cancer    pancreatitis    leukemia    endotheliitis
    neuronitis    breast cancer


    CDK20 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CDK20 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 37.5 2 8021495 (1), 11961048 (1)
    tumors 14.5 7 17565152 (1), 11961048 (1), 17439397 (1), 19672860 (1)
    cancer 7.69 7 15347600 (2), 15801830 (1), 15857291 (1), 17208431 (1) (see all 6)
    prostate cancer 0 2 17531530 (2)

    Genetic Association Database (GAD): CDK20

    Export disorders for CDK20 gene to outside databases

    Publications
    for CDK20 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK20 gene, integrated from 9 sources (see all 115):
    (articles sorted by number of sources associating them with CDK20)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. (PubMed id 14597612)1, 2, 9 Liu Y.... Galaktionov K. (2004)
    2. Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/C(CDH1). (PubMed id 21986944)1, 2 Wang L.Y. and Kung H.J. (2012)
    3. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. (PubMed id 19672860)1, 9 Wu G.Q....Kung H.F. (2009)
    7. Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. (PubMed id 16954377)1, 9 Fu Z....Sturgill T.W. (2006)
    8. Functional genomics identifies drivers of medulloblast oma dissemination. (PubMed id 22875024)1 Mumert M....Fults D.W. (2012)
    9. Cell cycle-related kinase is a direct androgen recept or-regulated gene that drives I^-catenin/T cell factor-dependent hepatocarcinoge nesis. (PubMed id 21747169)1 Feng H....Sung J.J. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for CDK20 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDK20 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23552 HGNC: 21420 AceView: CCRK Ensembl:ENSG00000156345 euGenes: HUgn23552
    ECgene: CDK20 H-InvDB: CDK20

    Other Databases showing CDK20 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDK20 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK20 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK20 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccrk/

    Intellectual Property
    for CDK20 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDK20 gene:
    Search GeneIP for patents involving CDK20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CDK20 gene

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    About This Section

     
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