Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CDK20 Gene

protein-coding   GIFtS: 51
GCID: GC09M090582

Cyclin-Dependent Kinase 20

(Previous name: cell cycle related kinase)
(Previous symbol: CCRK)
  See CDK20-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cyclin-Dependent Kinase 201 2     CAK-Kinase P422 3
CCRK1 2 3 5     CDK-Activating Kinase P422 3
CDCH2 3 5     EC 2.7.11.223 8
Cell Cycle-Related Kinase2 3     P422 5
Cell Division Protein Kinase 202 3     Cell Cycle Related Kinase1
Cyclin-Dependent Protein Kinase H2 3     PNQALRE2
Cyclin-Kinase-Activating Kinase P422 3     EC 2.7.118

External Ids:    HGNC: 214201   Entrez Gene: 235522   Ensembl: ENSG000001563457   OMIM: 6100765   UniProtKB: Q8IZL93   

Export aliases for CDK20 gene to outside databases

Previous GC identifers: GC09M089772 GC09M060404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CDK20 Gene:
The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein
kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively
spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Dec 2009)

GeneCards Summary for CDK20 Gene:
CDK20 (cyclin-dependent kinase 20) is a protein-coding gene. Diseases associated with CDK20 include mantle cell lymphoma. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDKL1.

UniProtKB/Swiss-Prot: CDK20_HUMAN, Q8IZL9
Function: Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the
structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be
properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a
kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CDK20
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK20 promoter sequence
   Search Chromatin IP Primers for CDK20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1   Ensembl cytogenetic band:  9q22.1   HGNC cytogenetic band: 9q22.1

CDK20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK20 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M090582:  view genomic region     (about GC identifiers)

Start:
90,581,356 bp from pter      End:
90,589,695 bp from pter
Size:
8,340 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CDK20_HUMAN, Q8IZL9 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 20  
Size: 346 amino acids; 38695 Da
Subunit: Monomer. Interacts with TBC1D32 (By similarity). Interacts with MAK
Sequence caution: Sequence=AAC98920.1; Type=Frameshift; Positions=331; Sequence=CAH72843.1; Type=Erroneous gene
model prediction;
Secondary accessions: A2A389 A2A390 B4DQX1 O95137 Q5EDC4 Q5VYW1 Q9BUF4
Alternative splicing: 5 isoforms:  Q8IZL9-1   Q8IZL9-2   Q8IZL9-3   Q8IZL9-4   Q8IZL9-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK20: NX_Q8IZL9

Explore proteomics data for CDK20 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK20 (Q8IZL9) (see all 5)
     VHRDLKP  IVHRDLK  VGCIMGE  PLEEVLPD 


    See CDK20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001034892.1  NP_001164110.1  NP_001164111.1  NP_036251.2  NP_848519.1  

    ENSEMBL proteins: 
     ENSP00000338975   ENSP00000365043   ENSP00000365031   ENSP00000474485   ENSP00000322343  

    CDK20 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CDK20
    OriGene Protein Over-expression Lysate for CDK20
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CDK20
    GenScript Custom Purified and Recombinant Proteins Services for CDK20
    Novus Biologicals CDK20 Proteins
    Novus Biologicals CDK20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK20

     
    Search eBioscience for Proteins for CDK20 

    CDK20 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CDK20
    OriGene Custom Antibody Services for CDK20
    Novus Biologicals CDK20 Antibodies
    Search for Antibodies for CDK20 at Abcam
    Cloud-Clone Corp. Antibodies for CDK20
    ThermoFisher Antibodies for CDK20
    LSBio Antibodies in human, mouse, rat for CDK20

    CDK20 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK20
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK20
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK20
    Cloud-Clone Corp. CLIAs for CDK20
    Search eBioscience for ELISAs for CDK20 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 20
    CCRK subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q8IZL9

    ProtoNet protein and cluster: Q8IZL9

    UniProtKB/Swiss-Prot: CDK20_HUMAN, Q8IZL9
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDK20           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK20_HUMAN, Q8IZL9
    Function: Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the
    structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be
    properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a
    kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CDK20           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for CDK20:
     Decreased Salmonella enterica   Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased telomerase activity 
     Decreased viability of wild-ty  Increased apoptosis  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK20

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK20:
    hsa-mir-615-3p (MIRT039839), hsa-mir-335-5p (MIRT017181)

    Block miRNA regulation of human, mouse, rat CDK20 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CDK20:
    hsa-miR-4251
    SwitchGear 3'UTR luciferase reporter plasmidCDK20 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDK20
    Predesigned siRNA for gene silencing in human, mouse, rat CDK20

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDK20

    Clone
    Products:
         
    OriGene clones in human, mouse for CDK20 (see all 30)
    OriGene ORF clones in mouse, rat for CDK20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): CDK20 (NM_178432)
    Sino Biological Human cDNA Clone for CDK20
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK20
    Addgene plasmids for CDK20 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDK20
    Browse ESI BIO Cell Lines and PureStem Progenitors for CDK20 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CDK20_HUMAN, Q8IZL9: Nucleus. Cytoplasm (By similarity). Cell projection, cilium (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005929cilium IEA--

    Find genes that share ontologies with CDK20           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK20
    Interactions:

        Search GeneGlobe Interaction Network for CDK20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK20 (ENSP000003223434) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNHENSP000002568974STRING: ENSP00000256897
    CDK2ENSP000002669704STRING: ENSP00000266970
    CSNK2BENSP000003650254STRING: ENSP00000365025
    GTF2IRD1ENSP000002657554STRING: ENSP00000265755
    MAKENSP000003130214STRING: ENSP00000313021
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007275multicellular organismal development IEA--
    GO:0051301cell division IEA--

    Find genes that share ontologies with CDK20           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDK20

    2 HMDB Compounds for CDK20    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for CDK20 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavopiridol 61.5 1 10368639 (1)
    pd 98,059 44.6 2 19154444 (1)
    tyrosine 41.8 23 1692963 (5), 7722327 (3), 9748296 (2), 1879344 (2) (see all 10)
    okadaic acid 34.1 1 8389730 (1)
    threonine 33.2 1 1655537 (1)
    flavonoid 21.3 1 8610110 (1)
    wortmannin 17.8 1 12414747 (1)
    calcium 0 2 18649271 (1), 10732121 (1)
    phosphatidylinositol 0 2 8395016 (1), 9748296 (1)
    glutamate 0 2 9178950 (1)



    Find genes that share compounds with CDK20           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CDK20 gene (5 alternative transcripts): 
    NM_001039803.2  NM_001170639.1  NM_001170640.1  NM_012119.4  NM_178432.3  

    Unigene Cluster for CDK20:

    Cyclin-dependent kinase 20
    Hs.522274  [show with all ESTs]
    Unigene Representative Sequence: AF113130
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000459720 ENST00000603475 ENST00000336654 ENST00000375883(uc004apr.3 uc004aps.3 uc022bjj.1 uc004apt.3)
    ENST00000375871(uc004apu.3) ENST00000605159 ENST00000325303 ENST00000486228
    ENST00000604175 ENST00000605591
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDK20 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CDK20:
    hsa-miR-4251
    SwitchGear 3'UTR luciferase reporter plasmidCDK20 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDK20
    Predesigned siRNA for gene silencing in human, mouse, rat CDK20
    Clone
    Products:
         
    OriGene clones in human, mouse for CDK20 (see all 30)
    OriGene ORF clones in mouse, rat for CDK20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): CDK20 (NM_178432)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK20
    Addgene plasmids for CDK20 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CDK20
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK20
      QuantiTect SYBR Green Assays in human, mouse, rat CDK20
      QuantiFast Probe-based Assays in human, mouse, rat CDK20

    Additional mRNA sequence: 

    AF035013.1 AF113130.1 AK075325.1 AK298993.1 AY904367.1 BC002655.2 

    7 DOTS entries:

    DT.101982509  DT.92426077  DT.95372023  DT.111029  DT.100793518  DT.92426079  DT.100793519 

    Selected AceView cDNA sequences (see all 94):

    AA156950 NM_012119 CR607702 AI479563 BF056145 BF112052 NM_178432 CA489134 
    AV706756 AF035013 BM982394 CB992644 BE221274 BI757318 BI461940 BI772502 
    AW005816 AA319839 BI459329 BE467048 N59289 BX091841 BV199036 BX344376 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK20 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:                                            -                       -                                             
    SP2:                                                                    -                                             
    SP3:                                            -                       -                       -                     
    SP4:                                            -                                                                     
    SP5:                                            -                       -     -     -                                 


    ECgene alternative splicing isoforms for CDK20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CDK20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGAAGTG
    CDK20 Expression
    About this image


    CDK20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Oviduct
             Secondary follicles
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Hippocampus
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Heart (Cardiovascular System)
             Endocardial Tube Cells Endocardium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    CDK20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522274
        Custom PCR Arrays for CDK20
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDK20
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK20
    QuantiTect SYBR Green Assays in human, mouse, rat CDK20
    QuantiFast Probe-based Assays in human, mouse, rat CDK20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK20 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk201 , 5 cyclin-dependent kinase 201, 5 87.96(n)1
    94.22(a)1
      13 (33.26 cM)5
    1052781  NM_053180.21  NP_444410.11 
     644325535 
    lizard
    (Anolis carolinensis)
    Reptilia CDK206
    cyclin-dependent kinase 20
    74(a)
    1 ↔ 1
    2(86265723-86278000)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.75082 Transcribed sequence with weak similarity to protein more 75.48(n)    CF345571.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk201 cyclin-dependent kinase 20 68.5(n)
    74.02(a)
      494112  NM_001008655.1  NP_001008655.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68001 CG6800 53.52(n)
    43.73(a)
      42562  NM_142727.1  NP_650984.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dyf-186
    Protein DYF-18 (dyf-18) mRNA, complete cds
    32(a)
    1 → many
    IV(11798665-11801088) WBGene00010349
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KIN286
    Serine/threonine protein kinase, subunit of the tr...
    37(a)
    1 → many
    IV(267698-268699) YDL108W


    ENSEMBL Gene Tree for CDK20 (if available)
    TreeFam Gene Tree for CDK20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CDK20 gene
    CDKL12  CDKL22  CDKL52  CDKL32  CDK72  CDKL42  
    Selected SIMAP similar genes for CDK20 using alignment to 1 protein entry:     CDK20_HUMAN(see all similar genes):
    CCRK    CDK1    CDC2    CDK3    DKFZp686L20222    CDK17
    MAPK7    CDK7    CDC2L1    CDC2L2    CDK11A    CDK11B
    CDK18    CDK5    PCTK3    CDK16    CDK12    CDK15

    Find genes that share paralogs with CDK20           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CDK20 (see all 300)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922865611,2
    C--90582340(+) AGTGGA/TCCTGA 5 -- ut310--------
    rs1446861981,2
    C,F--90582380(+) TCTCAC/TCCCTC 8 G syn1 ut311Minor allele frequency- T:0.00NA 3134
    rs2009033881,2
    C--90582383(+) CACCCC/TTCCAG 8 E syn1 ut310--------
    rs567367341,2
    C,F--90582445(+) GTCCAA/C/TGTGGA 13 M V L mis1 ut311NA 3114
    rs1510848681,2
    C--90582463(+) GATGTG/CGGGGG 8 /H /D mis1 ut311Minor allele frequency- C:0.00NA 2906
    rs1413708311,2
    C,F--90582470(+) GGGGGC/GCCTGG 8 G syn1 ut311Minor allele frequency- G:0.00NA 2862
    rs43500711,2
    C,H--90582577(+) AGCCTG/CAGGGT 5 -- int14Minor allele frequency- C:0.00NS EA 372
    rs3691116681,2
    C--90582614(+) CTAGTC/GACCTC 5 -- int10--------
    rs1494460301,2
    --90582698(+) AGTGTC/GTACTA 5 -- int10--------
    rs1430332611,2
    C--90582703(+) CTACTA/GTGTCT 5 -- int10--------

    HapMap Linkage Disequilibrium report for CDK20 (90581356 - 90589695 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CDK20: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK20
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610076    OMIM disorders: --

    1 disease for CDK20:    
    About MalaCards
    mantle cell lymphoma


    Find genes that share disorders with CDK20           About GenesLikeMe

    4 Novoseek inferred disease relationships for CDK20 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 37.5 2 8021495 (1), 11961048 (1)
    tumors 14.5 7 17565152 (1), 11961048 (1), 17439397 (1), 19672860 (1)
    cancer 7.69 7 15347600 (2), 15801830 (1), 15857291 (1), 17208431 (1) (see all 6)
    prostate cancer 0 2 17531530 (2)

    Genetic Association Database (GAD): CDK20

    Export disorders for CDK20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CDK20 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with CDK20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. (PubMed id 14597612)1, 2, 9 Liu Y.... Galaktionov K. (J. Biol. Chem. 2004)
    2. Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/C(CDH1). (PubMed id 21986944)1, 2 Wang L.Y. and Kung H.J. (Oncogene 2012)
    3. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (Nat. Cell Biol. 2009)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. (PubMed id 19672860)1, 9 Wu G.Q....Kung H.F. (Int. J. Cancer 2009)
    7. Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. (PubMed id 16954377)1, 9 Fu Z....Sturgill T.W. (Mol. Cell. Biol. 2006)
    8. CCRK depletion inhibits glioblastoma cell proliferation in a cilium-dependent manner. (PubMed id 23743448)1 Yang Y....MAokelAo T.P. (EMBO Rep. 2013)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. Functional genomics identifies drivers of medulloblastoma dissemination. (PubMed id 22875024)1 Mumert M....Fults D.W. (Cancer Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23552 HGNC: 21420 AceView: CCRK Ensembl:ENSG00000156345 euGenes: HUgn23552
    ECgene: CDK20 H-InvDB: CDK20

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CDK20 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK20 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ccrk/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CDK20 gene:
    Search GeneIP for patents involving CDK20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CDK20   OriGene RNAi products in human, mouse, rat for CDK20  
     OriGene qPCR primer pairs and template standards for CDK20   OriGene Protein Over-expression Lysate for CDK20  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CDK20  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDK20   OriGene Purified Protein for CDK20  
     OriGene ORF clones in mouse, rat for CDK20   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDK20   OriGene Custom Protein Services for CDK20  

     
     
     Block miRNA regulation of human, mouse, rat CDK20 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CDK20
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK20 Predesigned siRNA for gene silencing in human, mouse, rat CDK20
     QuantiFast Probe-based Assays in human, mouse, rat CDK20 QuantiTect SYBR Green Assays in human, mouse, rat CDK20
     Custom PCR Arrays for CDK20 Search Chromatin IP Primers for CDK20
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK20  Search GeneGlobe Interaction Network for CDK20
     Search Regulatory tfbs for CDK20
     GenScript Custom Purified and Recombinant Proteins Services for CDK20 GenScript cDNA clones with any tag delivered in your preferred vector for CDK20
     GenScript Custom Assay Services for CDK20 GenScript Custom overexpressing Cell Line Services for CDK20
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CDK20
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CDK20
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CDK20 antibodies
     CDK20 proteins
     CDK20 lysates
     Search for Antibodies for CDK20 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CDK20
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CDK20
     Antibodies for CDK20
     ELISAs for CDK20
     CLIAs for CDK20



     Browse ESI BIO Cell Lines and PureStem Progenitors for CDK20
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK20
     SwitchGear 3'UTR luciferase reporter plasmids for CDK20
     SwitchGear Promoter luciferase reporter plasmids for CDK20
     ThermoFisher Antibodies for CDK20
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK20
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK20
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK20
     LSBio Antibodies in human, mouse, rat for CDK20
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for CDK20
      Search eBioscience for proteins for CDK20
      Search eBioscience for elisas for CDK20
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDK20 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4