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Aliases for CDK20 Gene

Aliases for CDK20 Gene

  • Cyclin-Dependent Kinase 20 2 3
  • CCRK 3 4 6
  • CDCH 3 4 6
  • Cyclin-Kinase-Activating Kinase P42 3 4
  • Cyclin-Dependent Protein Kinase H 3 4
  • Cell Division Protein Kinase 20 3 4
  • Cell Cycle-Related Kinase 3 4
  • CDK-Activating Kinase P42 3 4
  • CAK-Kinase P42 3 4
  • EC 2.7.11.22 4 63
  • P42 3 6
  • Cell Cycle Related Kinase 2
  • EC 2.7.11 63
  • PNQALRE 3

External Ids for CDK20 Gene

Previous HGNC Symbols for CDK20 Gene

  • CCRK

Previous GeneCards Identifiers for CDK20 Gene

  • GC09M089772
  • GC09M090582
  • GC09M060404

Summaries for CDK20 Gene

Entrez Gene Summary for CDK20 Gene

  • The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]

GeneCards Summary for CDK20 Gene

CDK20 (Cyclin-Dependent Kinase 20) is a Protein Coding gene. Diseases associated with CDK20 include mantle cell lymphoma. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDKL3.

UniProtKB/Swiss-Prot for CDK20 Gene

  • Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue Thr-160.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK20 Gene

Genomics for CDK20 Gene

Genomic Location for CDK20 Gene

Start:
87,966,441 bp from pter
End:
87,974,780 bp from pter
Size:
8,340 bases
Orientation:
Minus strand

Genomic View for CDK20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK20 Gene

No data available for Regulatory Elements for CDK20 Gene

Proteins for CDK20 Gene

  • Protein details for CDK20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZL9-CDK20_HUMAN
    Recommended name:
    Cyclin-dependent kinase 20
    Protein Accession:
    Q8IZL9
    Secondary Accessions:
    • A2A389
    • A2A390
    • B4DQX1
    • O95137
    • Q5EDC4
    • Q5VYW1
    • Q9BUF4

    Protein attributes for CDK20 Gene

    Size:
    346 amino acids
    Molecular mass:
    38695 Da
    Quaternary structure:
    • Monomer. Interacts with TBC1D32 (By similarity). Interacts with MAK.
    SequenceCaution:
    • Sequence=AAC98920.1; Type=Frameshift; Positions=331; Evidence={ECO:0000305}; Sequence=CAH72843.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK20 Gene

Proteomics data for CDK20 Gene at MOPED

Selected DME Specific Peptides for CDK20 Gene

Post-translational modifications for CDK20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for CDK20 Gene

Gene Families for CDK20 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

Suggested Antigen Peptide Sequences for CDK20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZL9

UniProtKB/Swiss-Prot:

CDK20_HUMAN :
  • Q8IZL9
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK20: view

Function for CDK20 Gene

Molecular function for CDK20 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue Thr-160.

Enzyme Numbers (IUBMB) for CDK20 Gene

Gene Ontology (GO) - Molecular Function for CDK20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 21986944
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK20: view
genes like me logo Genes that share phenotypes with CDK20: view

miRNA for CDK20 Gene

miRTarBase miRNAs that target CDK20

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK20 Gene

Localization for CDK20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK20 Gene

Nucleus. Cytoplasm. Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK20 Gene COMPARTMENTS Subcellular localization image for CDK20 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CDK20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with CDK20: view

Pathways for CDK20 Gene

SuperPathways for CDK20 Gene

No Data Available

Interacting Proteins for CDK20 Gene

Gene Ontology (GO) - Biological Process for CDK20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007275 multicellular organismal development IEA --
GO:0051301 cell division IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDK20: view

No data available for Pathways by source for CDK20 Gene

Compounds for CDK20 Gene

(2) HMDB Compounds for CDK20 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(12) Novoseek inferred chemical compound relationships for CDK20 Gene

Compound -log(P) Hits PubMed IDs
flavopiridol 61.5 1
pd 98,059 44.6 1
tyrosine 41.8 18
okadaic acid 34.1 1
threonine 33.2 1
genes like me logo Genes that share compounds with CDK20: view

Transcripts for CDK20 Gene

Unigene Clusters for CDK20 Gene

Cyclin-dependent kinase 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK20 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: -
SP3: - - -
SP4: -
SP5: - - - -
SP6: -
SP7: -

Relevant External Links for CDK20 Gene

GeneLoc Exon Structure for
CDK20
ECgene alternative splicing isoforms for
CDK20

Expression for CDK20 Gene

mRNA expression in normal human tissues for CDK20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDK20 Gene

SOURCE GeneReport for Unigene cluster for CDK20 Gene Hs.522274

genes like me logo Genes that share expressions with CDK20: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDK20 Gene

Orthologs for CDK20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK20 35
  • 96.05 (n)
  • 94.8 (a)
CDK20 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCRK 36
  • 92 (a)
OneToOne
CDK20 35
  • 88.63 (n)
  • 92.49 (a)
dog
(Canis familiaris)
Mammalia CDK20 35
  • 88.54 (n)
  • 93.35 (a)
CDK20 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk20 35
  • 87.96 (n)
  • 94.22 (a)
Cdk20 16
Cdk20 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK20 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK20 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk20 35
  • 87.38 (n)
  • 93.64 (a)
lizard
(Anolis carolinensis)
Reptilia CDK20 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7508 35
zebrafish
(Danio rerio)
Actinopterygii cdk20 35
  • 68.5 (n)
  • 74.02 (a)
cdk20 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004594 35
  • 52.76 (n)
  • 44.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6800 35
  • 53.52 (n)
  • 43.73 (a)
CG6800 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dyf-18 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KIN28 36
  • 37 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5990 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToOne
Species with no ortholog for CDK20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK20 Gene

ENSEMBL:
Gene Tree for CDK20 (if available)
TreeFam:
Gene Tree for CDK20 (if available)

Paralogs for CDK20 Gene

Paralogs for CDK20 Gene

genes like me logo Genes that share paralogs with CDK20: view

Variants for CDK20 Gene

Sequence variations from dbSNP and Humsavar for CDK20 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1167 -- 87,966,831(+) TGAAG(C/T)ACACA utr-variant-3-prime
rs508711 -- 87,971,772(+) GGCCA(C/G)TACTG intron-variant
rs555592 -- 87,968,141(+) GCAGC(A/G)TCATG intron-variant
rs555595 -- 87,968,142(+) CAGCG(G/T)CATGA intron-variant
rs560019 -- 87,968,606(+) CACCT(C/T)CTCAA intron-variant

Relevant External Links for CDK20 Gene

HapMap Linkage Disequilibrium report
CDK20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDK20 Gene

Disorders for CDK20 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CDK20 Gene including...

Search for CDK20 Gene in MalaCards »

(4) Novoseek inferred disease relationships for CDK20 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 37.5 2
tumors 14.5 4
cancer 7.69 7
prostate cancer 0 2

Relevant External Links for CDK20

Genetic Association Database (GAD)
CDK20
genes like me logo Genes that share disorders with CDK20: view

No data available for UniProtKB/Swiss-Prot for CDK20 Gene

Publications for CDK20 Gene

  1. p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. (PMID: 14597612) Liu Y. … Galaktionov K. (J. Biol. Chem. 2004) 3 4 23
  2. Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. (PMID: 19672860) Wu G.Q. … Kung H.F. (Int. J. Cancer 2009) 3 23
  3. Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. (PMID: 16954377) Fu Z. … Sturgill T.W. (Mol. Cell. Biol. 2006) 3 23
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CDK20 Gene

  • Addgene plasmids for CDK20

Sources for CDK20 Gene

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