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Aliases for CDK2 Gene

Aliases for CDK2 Gene

  • Cyclin-Dependent Kinase 2 2 3
  • Cell Division Protein Kinase 2 3 4
  • P33 Protein Kinase 3 4
  • EC 2.7.11.22 4 64
  • CDKN2 3 4
  • Cdc2-Related Protein Kinase 3
  • P33(CDK2) 3
  • EC 2.7.11 64

External Ids for CDK2 Gene

Summaries for CDK2 Gene

Entrez Gene Summary for CDK2 Gene

  • This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for CDK2 Gene

CDK2 (Cyclin-Dependent Kinase 2) is a Protein Coding gene. Diseases associated with CDK2 include melanoma and tetraploidy. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity and histone kinase activity. An important paralog of this gene is CDK1.

UniProtKB/Swiss-Prot for CDK2 Gene

  • Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity).

Tocris Summary for CDK2 Gene

  • Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases, including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability. Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK2 Gene

Genomics for CDK2 Gene

Genomic Location for CDK2 Gene

Start:
55,966,769 bp from pter
End:
55,972,784 bp from pter
Size:
6,016 bases
Orientation:
Plus strand

Genomic View for CDK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK2 Gene

Regulatory Elements for CDK2 Gene

Transcription factor binding sites by QIAGEN in the CDK2 gene promoter:

Proteins for CDK2 Gene

  • Protein details for CDK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24941-CDK2_HUMAN
    Recommended name:
    Cyclin-dependent kinase 2
    Protein Accession:
    P24941
    Secondary Accessions:
    • A8K7C6
    • O75100

    Protein attributes for CDK2 Gene

    Size:
    298 amino acids
    Molecular mass:
    33930 Da
    Quaternary structure:
    • Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1. Binds to RB1 and CDK7. Binding to CDKN1A (p21) leads to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair. Associated with PTPN6 and beta-catenin/CTNNB1. Interacts with CACUL1. May interact with CEP63. Interacts with ANKRD17. Interacts with CEBPA (when phosphorylated) (PubMed:15107404).

    Three dimensional structures from OCA and Proteopedia for CDK2 Gene

    Alternative splice isoforms for CDK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK2 Gene

Proteomics data for CDK2 Gene at MOPED

Post-translational modifications for CDK2 Gene

  • Nitrosylated after treatment with nitric oxide (DETA-NO).
  • Phosphorylated at Thr-160 by CDK7 in a CAK complex. Phosphorylation at Thr-160 promotes kinase activity, whereas phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S and G2 phases before being dephosphorylated by CDC25A.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys9, Lys56, Lys129, Lys142, Lys237, and Lys291

Other Protein References for CDK2 Gene

Domains for CDK2 Gene

Gene Families for CDK2 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

UniProtKB/Swiss-Prot:

CDK2_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P24941
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.:
    • P24941
genes like me logo Genes that share domains with CDK2: view

Function for CDK2 Gene

Molecular function for CDK2 Gene

GENATLAS Biochemistry: cyclin dependent kinase 2,involved in cell cycle regulation (G1 to S transition),complexing with cyclin E for the regulation of chromosome stability,activated in apoptosis by TP53 regulated,BAX and BCL2,putative checkpoint between cell cycle and cell death pathway
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160 activates it. Inhibited by 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), AG-024322, N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), R547 (Ro-4584820), purine, pyrimidine and pyridine derivatives, 2-aminopyrimidines, paullones, thiazo derivatives, macrocyclic quinoxalin-2-one, pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine, 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine, seliciclib and CYC202), SNS-032 (BMS-387032), triazolo[1,5-a]pyrimidines, staurosporine and olomoucine. Stimulated by MYC. Inactivated by CDKN1A (p21).
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity).
UniProtKB/Swiss-Prot Induction: Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis

Enzyme Numbers (IUBMB) for CDK2 Gene

Gene Ontology (GO) - Molecular Function for CDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity TAS --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 10330164
genes like me logo Genes that share ontologies with CDK2: view
genes like me logo Genes that share phenotypes with CDK2: view

Animal Models for CDK2 Gene

MGI Knock Outs for CDK2:

No data available for Transcription Factor Targeting and HOMER Transcription for CDK2 Gene

Localization for CDK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK2 Gene COMPARTMENTS Subcellular localization image for CDK2 gene
Compartment Confidence
cytoskeleton 5
endosome 5
nucleus 5
cytosol 4
extracellular 2
mitochondrion 2
peroxisome 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 8692841
GO:0000781 chromosome, telomeric region IEA --
GO:0000793 condensed chromosome IEA --
GO:0000805 X chromosome IEA --
GO:0000806 Y chromosome IEA --
genes like me logo Genes that share ontologies with CDK2: view

Pathways for CDK2 Gene

SuperPathways for CDK2 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Cyclins and Cell Cycle Regulation
3 Cell cycle Role of SCF complex in cell cycle regulation
4 Cellular Senescence
5 E2F mediated regulation of DNA replication
genes like me logo Genes that share pathways with CDK2: view

Gene Ontology (GO) - Biological Process for CDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication TAS 19238148
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with CDK2: view

Compounds for CDK2 Gene

(20) ApexBio Compounds for CDK2 Gene

Compound Action Cas Number
AT7519 novel small molecule effective as a multi-cyclin-dependent kinase inhibitor [844442-38-2]
AZD-5438 Potent CDK1/2/9 inhibitor [602306-29-6]
BMS265246 potent and selective Cdk1/Cdk2 inhibitor [582315-72-8]
BS-181 HCl small molecule inhibitor which is highly selective for Cdk7 activity [1397219-81-6]
Deferasirox rationally-designed oral iron chelator. [201530-41-8]
Dinaciclib (SCH727965) CDK inhibitor [779353-01-4]
Flavopiridol hydrochloride pan-cdk inhibitor. [131740-09-5]
LEE011 orally available CDK inhibitor. [1211441-98-3]
LY2835219 orally available CDK inhibitor, targets the CDK4 and CDK6 [1231930-82-7]
Nu 6027 potent inhibitor of cellular ATR activity [220036-08-8]
Palbociclib (PD0332991) Isethionate Highly selective CDK4/6 inhibitor [827022-33-3]
PD 0332991 (Palbociclib) HCl Highly selective CDK4/6 inhibitor [827022-33-3]
PHA-793887 novel pan-Cdk inhibitor [718630-59-2]
PHA-848125 potent, ATP-competitive Cdk2/cyclin A inhibitor. [802539-81-7]
Purvalanol B cyclin-dependent kinase inhibitor. [212844-54-7]
R547 novel, selective inhibitor of cell cycle and transcriptional CDK. [741713-40-6]
Roscovitine (Seliciclib,CYC202) potent and selective inhibitor of cyclin-dependent kinases [186692-46-6]
SB1317 novel pyrimidine-based multi-kinase inhibitor that inhibits CDKs 1, 2, 7 and 9 together with JAK2 and FLT3 [937270-47-8]
SCH900776 S-isomer potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 [891494-64-7]
SNS-032 (BMS-387032) Potent and selective CDK inhibitor [345627-80-7]

(5) Tocris Compounds for CDK2 Gene

Compound Action Cas Number
Kenpaullone Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3 [142273-20-9]
Purvalanol A Cyclin-dependent kinase inhibitor [212844-53-6]
Purvalanol B Cyclin-dependent kinase inhibitor [212844-54-7]
Ro 3306 Cyclin-dependent kinase (cdk) 1 inhibitor [872573-93-8]
SU 9516 Potent cdk2 inhibitor [377090-84-1]

(2) HMDB Compounds for CDK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(158) Novoseek inferred chemical compound relationships for CDK2 Gene

Compound -log(P) Hits PubMed IDs
roscovitine 89.5 82
olomoucine 86.5 34
nu2058 82 10
fascaplysin 80.2 2
flavopiridol 78.8 24
genes like me logo Genes that share compounds with CDK2: view

Transcripts for CDK2 Gene

Unigene Clusters for CDK2 Gene

Cyclin-dependent kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - - - -
SP5: - -
SP6:
SP7: - - - - -

Relevant External Links for CDK2 Gene

GeneLoc Exon Structure for
CDK2
ECgene alternative splicing isoforms for
CDK2

Expression for CDK2 Gene

mRNA expression in normal human tissues for CDK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK2 Gene

SOURCE GeneReport for Unigene cluster for CDK2 Gene Hs.19192

genes like me logo Genes that share expressions with CDK2: view

Orthologs for CDK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK2 36
  • 99.89 (n)
  • 100 (a)
CDK2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK2 36
  • 93.62 (n)
  • 98.66 (a)
CDK2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK2 36
  • 93.29 (n)
  • 98.99 (a)
CDK2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk2 36
  • 92.51 (n)
  • 98.99 (a)
Cdk2 16
Cdk2 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk2 36
  • 91.5 (n)
  • 98.99 (a)
chicken
(Gallus gallus)
Aves CDK2 36
  • 79.75 (n)
  • 93.29 (a)
CDK2 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK2 37
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4227 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk2 36
  • 77.36 (n)
  • 89.86 (a)
Str.2871 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9226 36
zebrafish
(Danio rerio)
Actinopterygii cdk2 36
  • 75.84 (n)
  • 90.27 (a)
cdk2 37
  • 90 (a)
OneToOne
Dr.17883 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004579 36
  • 60.94 (n)
  • 60.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta cdc2c 36
  • 62.81 (n)
  • 65.65 (a)
cdc2c 37
  • 60 (a)
OneToMany
cdc2c 38
  • 64 (a)
cdc2 38
  • 64 (a)
Cdk4 38
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea cdk-2 37
  • 40 (a)
ManyToMany
cdk-4 38
  • 38 (a)
cdk-1 38
  • 60 (a)
H01G02.2 38
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR058C 36
  • 63.3 (n)
  • 64.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC28 36
  • 61.37 (n)
  • 65.37 (a)
CDC28 37
  • 61 (a)
OneToMany
CDC28 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B09790g 36
  • 59.7 (n)
  • 62.37 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6720 36
thale cress
(Arabidopsis thaliana)
eudicotyledons CDC2 36
  • 63.21 (n)
  • 68.86 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10992 36
corn
(Zea mays)
Liliopsida Zm.12226 36
rice
(Oryza sativa)
Liliopsida Os.3428 36
Os03g0118400 36
  • 64.71 (n)
  • 69.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09778 36
  • 64.98 (n)
  • 68.01 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc2 36
  • 61.69 (n)
  • 67.36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5905 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5702 37
  • 67 (a)
OneToMany
Species with no ortholog for CDK2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK2 Gene

ENSEMBL:
Gene Tree for CDK2 (if available)
TreeFam:
Gene Tree for CDK2 (if available)

Paralogs for CDK2 Gene

Paralogs for CDK2 Gene

genes like me logo Genes that share paralogs with CDK2: view

Variants for CDK2 Gene

Sequence variations from dbSNP and Humsavar for CDK2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_016157 -
VAR_019988 -
VAR_053927 -
VAR_041972 A glioblastoma multiforme sample

Structural Variations from Database of Genomic Variants (DGV) for CDK2 Gene

Variant ID Type Subtype PubMed ID
nsv832424 CNV Loss 17160897

Relevant External Links for CDK2 Gene

HapMap Linkage Disequilibrium report
CDK2

Disorders for CDK2 Gene

(2) MalaCards Diseases for CDK2 Gene

Search for CDK2 Gene in MalaCards »

(4) University of Copenhagen DISEASES for CDK2 Gene

(94) Novoseek inferred disease relationships for CDK2 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 89.6 106
cancer 66.2 82
tumors 61.5 117
breast cancer 53.6 60
colon cancer 50.1 4

Relevant External Links for CDK2

Genetic Association Database (GAD)
CDK2
Human Genome Epidemiology (HuGE) Navigator
CDK2
Tumor Gene Database (TGDB):
CDK2
genes like me logo Genes that share disorders with CDK2: view

No data available for UniProtKB/Swiss-Prot for CDK2 Gene

Publications for CDK2 Gene

  1. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. (PMID: 1396589) Gu Y. … O'Morgan D.O. (EMBO J. 1992) 3 4 23
  2. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. (PMID: 9030781) Meijer L. … Moulinoux J.-P. (Eur. J. Biochem. 1997) 3 4 23
  3. Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. (PMID: 8275715) Demetrick D.J. … Beach D.H. (Cytogenet. Cell Genet. 1994) 2 3 23
  4. Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. (PMID: 8684460) Russo A.A. … Pavletich N.P. (Nature 1996) 3 4 23
  5. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. (PMID: 8610110) de Azevedo W.F. Jr. … Kim S.-H. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23

Products for CDK2 Gene

  • Addgene plasmids for CDK2

Sources for CDK2 Gene

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