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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK2 Gene

protein-coding   GIFtS: 76
GCID: GC12P056360

cyclin-dependent kinase 2
 Explore 134 diseases affiliated with
CDK2 via
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Biological research products
for CDK2    

Aliases
for CDK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase 21 2     Cell Devision Kinase 22
Cell Division Protein Kinase 22 3     P33(CDK2)1
P33 Protein Kinase2 3     CDKN23
EC 2.7.11.223 8     EC 2.7.118
Cdc2-Related Protein Kinase2     

External Ids:    HGNC: 17711   Entrez Gene: 10172   Ensembl: ENSG000001233747   OMIM: 1169535   UniProtKB: P249413   

Export aliases for CDK2 gene to outside databases

Previous GC identifers: GC12M056216 GC12P056923 GC12P056077 GC12P054646 GC12P053399


Summaries
for CDK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDK2:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly
similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the
cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle
G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including
cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein
phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been
reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CDK2_HUMAN, P24941
Function: Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but
dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts
with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote
the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing
of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and
coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine
balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of
CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis
to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of
DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3
maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative
stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that
prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by
phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells
progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a
reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1
phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome
duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the
NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth
inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a
nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition.
CTNNB1 phosphorylation regulates insulin internalization

summary for CDK2:
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through
the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk
genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following
extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D
and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces
transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E
complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M
phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation
of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,
including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by
molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks
is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.
Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to
Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential
targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic
strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK2 (Cyclin-dependent kinase 2)


Genomic Views
for CDK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK2 gene promoter:
         C/EBPbeta   Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13

CDK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056360:  view genomic region     (about GC identifiers)

Start:
 56,360,553 bp from pter      End:
 56,366,568 bp from pter
Size:
 6,016 bases      Orientation:
 plus strand

Proteins
for CDK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDK2_HUMAN, P24941 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 2  
Size: 298 amino acids; 33930 Da
Subunit: Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with
UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and
SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1. Binds to RB1 and CDK7. Binding to CDKN1A (p21) leads to
CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition
during DNA repair. Associated with PTPN6 and beta-catenin/CTNNB1. Interacts with CACUL1. May interact with CEP63
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at
the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase.
Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3)
6/315 PDB 3D structures from and Proteopedia for CDK2 (see all 315):
1AQ1 (3D)        1B38 (3D)        1B39 (3D)        1BUH (3D)        1CKP (3D)        1DI8 (3D)    
Secondary accessions: A8K7C6 O75100
Alternative splicing: 2 isoforms:  P24941-1   P24941-2   

Explore the universe of human proteins at neXtProt for CDK2: NX_P24941

Post-translational modifications:

  • Phosphorylated at Thr-160 by CDK7 in a CAK complex. Phosphorylation at Thr-160 promotes kinase activity, whereas
    • phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S and
    G2 phases before being dephosphorylated by CDC25A1
  • Nitrosylated after treatment with nitric oxide (DETA-NO)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P24941

    • 4/25 DME Specific Peptides for CDK2 (P24941) (see all 25)
     VVTLWYR  DFGLARA  EGVPSTA  LADFGLA 

    CDK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001789.2  NP_439892.2  

    ENSEMBL proteins: 
     ENSP00000266970   ENSP00000450983   ENSP00000452514   ENSP00000393605   ENSP00000452138  
     ENSP00000243067  
    Reactome Protein details: P24941
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CDK2 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CDK2
    OriGene Purified Protein: CDK2
    OriGene Protein Over-expression Lysate (see all 2): CDK2
    OriGene Custom Protein Services for CDK2 
    GenScript Custom Purified and Recombinant Proteins Services for CDK2
    Novus Biologicals CDK2 Proteins
    Novus Biologicals CDK2 Lysates
    Sino Biological Recombinant Protein for CDK2
    ProSpec Recombinant Protein for CDK2
    Uscn Proteins for CDK2

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA8692841
    GO:0000781chromosome, telomeric region IEA--
    GO:0000793condensed chromosome IEA--
    GO:0000805X chromosome IEA--
    GO:0000806Y chromosome IEA--


    CDK2 for ontologies           About GeneDecksing



    CDK2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK2
    R&D Systems Antibodies for CDK2
    Cell Signaling Technology (CST) Antibodies for CDK2 
    OriGene Antibodies (see all 13): CDK2
    OriGene Custom Antibody Services for CDK2 
    GenScript Superior Antibodies for CDK2
    Novus Biologicals CDK2 Antibodies
    Abcam antibodies for CDK2 
    Uscn Antibodies for CDK2
    ThermoFisher Antibody for CDK2

    Assay Products for CDK2: 
    EMD Millipore Kits and Assays for the Analysis of CDK2
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CDK2

    Protein Domains /
    Families
    for CDK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDK2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P24941

    ProtoNet protein and cluster: P24941

    UniProtKB/Swiss-Prot: CDK2_HUMAN, P24941
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CDK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDK2_HUMAN, P24941
    Function: Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but
    dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts
    with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote
    the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing
    of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and
    coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine
    balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of
    CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis
    to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of
    DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3
    maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative
    stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that
    prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by
    phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells
    progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a
    reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1
    phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome
    duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the
    NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth
    inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a
    nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition.
    CTNNB1 phosphorylation regulates insulin internalization
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160
    activates it. Inhibited by 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), AG-024322,
    N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), R547 (Ro-4584820), purine,
    pyrimidine and pyridine derivatives, 2-aminopyrimidines, paullones, thiazo derivatives, macrocyclic quinoxalin-2-one,
    pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine,
    2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine, seliciclib and CYC202), SNS-032
    (BMS-387032), triazolo[1,5-a]pyrimidines, staurosporine and olomoucine. Stimulated by MYC. Inactivated by CDKN1A (p21)
    Induction: Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis

         Genatlas biochemistry entry for CDK2:
    cyclin dependent kinase 2,involved in cell cycle regulation (G1 to S transition),complexing with cyclin E for the
    regulation of chromosome stability,activated in apoptosis by TP53 regulated,BAX and BCL2,putative checkpoint between
    cell cycle and cell death pathway

    Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target CDK2:
    hsa-mir-103 (MIRT004764), hsa-mir-885-5p (MIRT005461), hsa-mir-124 (MIRT004283), hsa-mir-302d (MIRT005672)

    OriGene 3'-UTR Clone (see all 2): CDK2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK2
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK2 (see all 36):
    hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-765 hsa-miR-519a hsa-miR-649 hsa-miR-372 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: CDK2 3' UTR sequence
    Inhib. RNA
    Products:            		EMD Millipore RNAi Products for the Analysis of CDK2 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK2 (see all 7)
    OriGene shRNA RFP: CDK2
    OriGene siRNA: CDK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CDK2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK2 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK2 (NM_052827)
    Sino Biological Human cDNA Clone for CDK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CDK2
    Search LifeMap BioReagents cell lines for CDK2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK2

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein kinase activity TAS--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    CDK2 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for CDK2:
     Decreased substrate adherent c  Increased cell death HMECs cel  Increased cell number in G2M,   Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for CDK2: Cdk2tm1Kald Cdk2tm1Sgo
         15 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cdk2):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  muscle  reproductive system  tumorigenesis  vision/eye 

    CDK2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/63 super-pathways (see all 63) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/21 pathways (see all 21)
    		CDK-mediated phosphorylation and removal of Cdc60.94
    		Cyclin A:Cdk2-associated events at S phase entry0.66
    		p53-Dependent G1/S DNA damage checkpoint0.83
    		DNA Replication Pre-Initiation0.62
    		p53-Dependent G1 DNA Damage Response0.83
    		M/G1 Transition0.62
    		G1/S DNA Damage Checkpoints0.79
    		Regulation of APC/C activators between G1/S and early anaphase0.62
    2Cell cycle_Cell cycle (generic schema)
    		Cell cycle_Cell cycle (generic schema)1.00
    		Cell cycle Regulation of G1/S transition (part 2)0.38
    		Cell cycle Cell cycle (generic schema)1.00
    		G0 and Early G10.31
    		Cell cycle_Regulation of G1/S transition (part 2)0.38
    3Cyclins and Cell Cycle Regulation
    		Cyclins and Cell Cycle Regulation1.00
    		Cell Cycle Control by BTG Proteins0.36
    		G1-S Phase Transition0.67
    4Chks in Checkpoint Regulation
    		Chks in Checkpoint Regulation1.00
    		p53 Signaling0.32
    		Estrogen-mediated S-Phase Entry0.55
    5Cell cycle
    		Cell cycle1.00
    		G1 to S cell cycle control0.38
    		Cell cycle0.57

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/13 EMD Millipore Pathways for CDK2 (see all 13)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Regulation of G1/S transition (part 2)
    Cell cycle Role of APC in cell cycle regulation
    Meiosis
    Cell cycle Regulation of G1/S transition (part 1)

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK2 (see all 15)
        Cell Cycle Control by BTG Proteins
    Molecular Mechanisms of Cancer
    Calpain Protease Regulates Cellular Mechanics
    Glioblastoma Multiforme
    DNA Damage Induced 14-3-3Sigma Signaling

    1 Cell Signaling Technology (CST) Pathway for CDK2
        Cell Cycle / Checkpoint Control

    5/11 GeneGo (Thomson Reuters) Pathways for CDK2 (see all 11)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription P53 signaling pathway
    Cell cycle Cell cycle (generic schema)
    Cell cycle Role of SCF complex in cell cycle regulation
    Immune response MIF-JAB1 signaling

    5/26 BioSystems Pathways for CDK2 (see all 26) 
        Signaling Pathways in Glioblastoma
    Cell cycle
    Oncostatin M Signaling Pathway
    Integrated Breast Cancer Pathway
    G1 to S cell cycle control

    5/38        Reactome Pathways for CDK2 (see all 38)
        Activation of ATR in response to replication stress
    G0 and Early G1
    Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6
    G1/S DNA Damage Checkpoints


    5/8         Kegg Pathways  (Kegg details for CDK2) (see all 8):
        Cell cycle
    Oocyte meiosis
    p53 signaling pathway
    Progesterone-mediated oocyte maturation
    Measles


    CDK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/302 Interacting proteins for CDK2 (P249411, 2, 3 ENSP000002669704) via UniProtKB, MINT, STRING, and/or I2D (see all 302)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN1AP389361, 2, 3, ENSP000002447414EBI-375096,EBI-375077 MINT-2635357 MINT-73323 MINT-3370697 MINT-50415 I2D: score=13 STRING: ENSP00000244741
    CDKN3Q166671, 2, 3, ENSP000003353574EBI-375096,EBI-1031527 MINT-17387 MINT-17388 MINT-24981 I2D: score=6 STRING: ENSP00000335357
    CDKN1BP465271, 2, 3, ENSP000002288724EBI-375096,EBI-519280 MINT-3379700 I2D: score=8 STRING: ENSP00000228872
    CCNA2P202481, 3, ENSP000002740264EBI-375096,EBI-457097 I2D: score=9 STRING: ENSP00000274026
    CCNE2O960201, 3, ENSP000003091814EBI-375096,EBI-375033 I2D: score=6 STRING: ENSP00000309181
    About this table

    Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000085G2 phase of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle NAS1653904


    CDK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK2 for compounds           About GeneDecksing

    EMD Millipore small molecules for CDK2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CDK2

    Compounds for CDK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 9516Potent cdk2 inhibitor[377090-84-1]
    Ro 3306Cyclin-dependent kinase (cdk) 1 inhibitor[872573-93-8]
    Purvalanol ACyclin-dependent kinase inhibitor[212844-53-6]
    Purvalanol BCyclin-dependent kinase inhibitor[212844-54-7]
    OlomoucineCyclin-dependent kinase inhibitor[101622-51-9]
    NU 2058Cdk1 and cdk2 inhibitor[161058-83-9]

    2 HMDB Compounds for CDK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10/135 DrugBank Compounds for CDK2 (see all 135)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Hymenialdisine-- --targetinhibitor17139284 11752352 17016423 10592235
    Olomoucine-- 101622-51-9targetinhibitor17139284 11752352 17016423 10592235
    SU9516-- --targetinhibitor17139284 11752352 17016423 10592235
    (2e,3s)-3-Hydroxy-5'-[(4-Hydroxypiperidin-1-Yl)Sulfonyl]-3-Methyl-1,3-Dihydro-2,3'-Biindol-2'(1'h)-One-- --target--17139284 17016423 10592235
    (5-Chloropyrazolo[1,5-a]Pyrimidin-7-Yl)-(4-Methanesulfonylphenyl)Amine-- --target--17139284 17016423 10592235
    1-Amino-6-Cyclohex-3-Enylmethyloxypurine-- --target--17139284 17016423 10592235
    1-[(2-Amino-6,9-Dihydro-1h-Purin-6-Yl)Oxy]-3-Methyl-2-Butanol-- --target--17139284 17016423 10592235
    2-[Trans-(4-Aminocyclohexyl)Amino]-6-(Benzyl-Amino)-9-Cyclopentylpurine-- --target--17139284 17016423 10592235
    3-Pyridin-4-Yl-2,4-Dihydro-Indeno[1,2-.C.]Pyrazole-- --target--17139284 17016423 10592235
    3-[4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol-- --target--17139284 17016423 10592235

    10/158 Novoseek chemical compound relationships for CDK2 gene (see all 158)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    roscovitine 89.5 102 9030780 (4), 9288122 (4), 9841966 (3), 16575928 (3) (see all 66)
    olomoucine 86.5 42 9288122 (4), 9841966 (3), 10234573 (3), 11896531 (2) (see all 25)
    nu2058 82 16 19426695 (6), 17599054 (2), 10956187 (1), 14657672 (1)
    fascaplysin 80.2 2 16750360 (1), 10973815 (1)
    flavopiridol 78.8 26 8674031 (3), 15185335 (2), 11289134 (2), 12852762 (2) (see all 19)
    nu6102 78 3 15928920 (2), 19426695 (1)
    su9516 77.4 11 12234612 (4), 11507069 (2), 14550307 (2), 12749903 (1)
    7-hydroxystaurosporine 71 3 10665655 (1), 15715961 (1), 12181445 (1)
    purvalanol 67.7 4 16168436 (1), 16733081 (1), 16140252 (1)
    aminopurvalanol 66.6 1 10220373 (1)

    Search CenterWatch for drugs/clinical trials and news about CDK2 

    Transcripts
    for CDK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDK2 gene (2 alternative transcripts): 
    NM_001798.3  NM_052827.2  

    Unigene Cluster for CDK2:

    Cyclin-dependent kinase 2
    Hs.19192  [show with all ESTs]
    Unigene Representative Sequence: NM_001798
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266970(uc001sit.4 uc001siu.4 uc010spy.2) ENST00000556464
    ENST00000555408 ENST00000553376 ENST00000440311 ENST00000555357 ENST00000354056
    ENST00000554619 ENST00000556276 ENST00000556656 ENST00000556146 ENST00000554545


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): CDK2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK2
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK2 (see all 36):
    hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-765 hsa-miR-519a hsa-miR-649 hsa-miR-372 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: CDK2 3' UTR sequence
    Inhib. RNA
    Products:             		EMD Millipore RNAi Products for the Analysis of CDK2 Gene knock-down
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK2 (see all 7)
    OriGene shRNA RFP: CDK2
    OriGene siRNA: CDK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK2 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK2 (NM_052827)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK2 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK2

    Additional cDNA sequence: 

    AB012305.1 AK291941.1 AK293246.1 BC003065.2 BT006821.1 M68520.1 X61622.1 X62071.1 

    15 DOTS entries:

    DT.95327485  DT.92441495  DT.99990963  DT.313922  DT.91866813  DT.95107346  DT.95326857  DT.100893294 
    DT.121208040  DT.92441489  DT.92441490  DT.92436457  DT.95190554  DT.97862514  DT.75102502 

    24/232 AceView cDNA sequences (see all 232):

    BQ215672 BQ220088 BQ217507 BQ049334 AU119029 BQ421647 AU139504 CB112879 
    BX343446 BX324447 AA463909 BQ218421 BU172812 BI093689 BQ434863 CR610978 
    BX336328 AL121503 BU174856 AA810989 BQ230342 AU131320 BX397060 CB129784 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDK2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
    SP1:                          -     -     -     -                                                   
    SP2:                          -     -     -     -                       -                           
    SP3:                                            -                                                   
    SP4:                          -     -     -     -                       -                           
    SP5:                                      -     -                                                   


    ECgene alternative splicing isoforms for CDK2

    Expression
    for CDK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCACCTTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDK2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSecondary SpermatocyteGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CDK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK2

    SOURCE GeneReport for Unigene cluster: Hs.19192
        SABiosciences Expression via Pathway-Focused PCR Arrays including CDK2 (see all 9): 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK2

    Orthologs
    for CDK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK2 gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDK21 cyclin-dependent kinase 2 79.75(n)
    93.29(a)    		   100529062  NM_001199857.1  NP_001186786.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CDK26
    		 --
    		 92(a)
    		 1 ↔ 1
    		 GL343198.1(3371965-3384039)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.42272 X. laevis Eg1 mRNA for serine/threonine kinase (cdc2) more 78.65(n)    X14227.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.178832 Danio rerio cDNA clone MGC56598 IMAGE5915295, complete more 76.04(n)    BC049499.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta cdc23
    cdc2c1    		 G2/M transition of mitotic cell cycle
    protein more3
    CG10498-PA1    		 64(a)
    (best of 3)3
    62.81(n)1
    65.65(a)1    		   31D113
    424531  NM_001170195.11  NP_001163666.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea cdk-13 serine/threonine kinase (CDC2/CDKX
    subfamily)    		 60(a)
    (best of 3)    		   III(9819189-9820383)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes CDC28(YBR160W)4
    CDC281    		 Catalytic subunit of the main cell cycle cyclin-dependent more4
    Cdc28p1    		 61.37(n)1
    65.37(a)1    		   2(560078-560974)4
    8524571, 4  NP_009718.31  NP_009718.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CDC21 cyclin-dependent kinase A-1 63.21(n)
    68.86(a)    		   824036  NM_114734.3  NP_566911.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.34282 O.sativa Rcdc2-2 gene for p34-cdc2 protein kinase 77.16(n)    AK101344.1 


    ENSEMBL Gene Tree for CDK2 (if available)
    TreeFam Gene Tree for CDK2 (if available) 

    Paralogs
    for CDK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK2 gene
    CDK62  CDK182  CDK52  CDK152  CDK42  CDK12  CDK32  CDK142  
    CDK162  CDK172  
    18/81 SIMAP similar genes for CDK2 using alignment to 4 protein entries:     CDK2_HUMAN (see all proteins) (see all similar genes):
    CDK3    MAP4K2    MAP4K3    MAP4K5    STK4    CDK18
    CDK1    CDC2    STK11    CDK17    CDKL4    CDK11A
    CDK16    CDK14    CDK11B    CDC2L1    DKFZp686L20222    CDKL1

    CDK2 for paralogs           About GeneDecksing



    Genomic Variants
    for CDK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/131 NCBI SNPs in CDK2 are shown (see all 131)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1846887151,2
    		--56358737(+) GACGGA/CGACTC 5 -- int1 us2k10--------
    rs1998447021,2
    		--56358901(+) GAGAC-/GGGGGT 5 -- int1 us2k10--------
    rs1897107591,2
    		--56359006(+) GCGCCC/TGGCCT 5 -- int1 us2k10--------
    rs123098951,2
    		C,F,H,--56359085(+) GAGCAT/ACCCAC 5 -- us2k1 int111Minor allele frequency- A:0.07NS EA NA CSA WA 796
    rs1809618761,2
    		--56359156(+) AGCAGC/TACGGG 5 -- int1 us2k10--------
    rs754795861,2
    		C,F,--56359426(+) TCTCCT/CGCACA 5 -- us2k1 int13Minor allele frequency- C:0.13CSA WA 122
    rs1141233261,2
    		F,--56359606(+) CAAATG/AAGTGG 5 -- us2k1 int11Minor allele frequency- A:0.03WA 118
    rs20693891,2
    		C,F,H,--56359642(+) CTCCCA/GTTAGG 5 -- int1 us2k16Minor allele frequency- G:0.02NA NS EA 702
    rs20693901,2
    		H--56359645(+) CCATTA/TGGAGG 5 -- us2k1 int15Minor allele frequency- T:0.00NA NS EA 576
    rs1848963911,2
    		C,--56359678(+) TTCATC/TCCCAA 5 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for CDK2 (56360553 - 56366568 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CDK2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK2
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK2

    Disorders / Diseases
    for CDK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDK2 for disorders           About GeneDecksing

    OMIM gene information: 116953    OMIM disorders: --

    20/134 diseases for CDK2 (see all 134):    About MalaCards
    leukemia    malignant peripheral nerve sheath tumor    melanoma    smooth muscle tumor
    diffuse large b-cell lymphoma    human t-cell leukemia virus type 1    cervical intraepithelial neoplasia    dna topoisomerase ii
    non-small cell lung carcinoma    adenomatous polyposis coli    b-cell lymphomas    germ cell tumor
    laryngeal squamous cell carcinoma    anaplastic large cell lymphoma    testicular germ cell tumor    male germ cell tumor
    clear cell renal cell carcinoma    non-hodgkin lymphoma    squamous cell carcinoma    pemphigus vulgaris

    4 diseases from the University of Copenhagen DISEASES database for CDK2:
    Retinoblastoma     Breast cancer     Carcinoma     Leukemia

    10/94 Novoseek disease relationships for CDK2 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 89.6 154 7954429 (2), 9103470 (2), 16824683 (2), 9492054 (2) (see all 99)
    cancer 66.2 103 20423616 (4), 12888290 (2), 16740735 (2), 19525400 (2) (see all 72)
    tumors 61.5 155 11585414 (4), 11299721 (3), 12352662 (3), 10995786 (2) (see all 99)
    breast cancer 53.6 77 8867812 (3), 20010939 (3), 17671085 (3), 10995786 (2) (see all 46)
    colon cancer 50.1 4 12920809 (1), 15763423 (1), 10216486 (1), 12676582 (1)
    prostate cancer 48.7 22 20147522 (3), 9492054 (2), 12954644 (2), 11062725 (1) (see all 12)
    prostate carcinoma 47 3 9794232 (1), 11052627 (1), 12352461 (1)
    colon carcinoma 41 3 7601562 (1), 12234612 (1), 11052627 (1)
    carcinoma squamous cell 35.5 15 11710944 (2), 10390005 (2), 11267947 (1), 11676482 (1) (see all 12)
    pancreatic cancer 35.5 5 9841966 (1), 11376563 (1), 15084985 (1), 19639215 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: CDK2 (14 documents)
    Tumor Gene Database (TGDB): CDK2

    Export disorders for CDK2 gene to outside databases

    Publications
    for CDK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK2 gene, integrated from 9 sources (see all 1852):
    (articles sorted by number of sources associating them with CDK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation. (PubMed id 1717994)1, 2, 3, 9 Ninomiya-Tsuji J.... Matsumoto K. (1991)
    2. Nuclear targeting of cyclin-dependent kinase 2 reveal s essential roles of cyclin-dependent kinase 2 localization and cyclin E in vit amin D-mediated growth inhibition. (PubMed id 20147522)1, 2, 9 Flores O....Burnstein K.L. (2010)
    3. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. (PubMed id 1396589)1, 2, 9 Gu Y.... O'Morgan D.O. (1992)
    4. Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. (PubMed id 11113184)1, 2, 9 Garrett S....Fisher R.P. (2001)
    5. High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design. (PubMed id 8917641)1, 2, 9 Schulze-Gahmen U.... Kim S.-H. (1996)
    6. Chromosomal mapping of human CDK2, CDK4, and CDK5 cel l cycle kinase genes. (PubMed id 8275715)1, 3, 9 Demetrick D.J....Beach D.H. (1994)
    7. Cdk2 nitrosylation and loss of mitochondrial potentia l mediate NO-dependent biphasic effect on HL-60 cell cycle. (PubMed id 20079829)1, 2, 9 Kumar S....Dikshit M. (2010)
    8. Cyclin B and cyclin A confer different substrate recognition properties on CDK2. (PubMed id 17495531)1, 2, 9 Brown N.R....Johnson L.N. (2007)
    9. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. (PubMed id 10499802)1, 2, 9 Harbour J.W....Dean D.C. (1999)
    10. Phosphorylation by Cdk2 is required for Myc to repres s Ras-induced senescence in cotransformation. (PubMed id 19966300)1, 2, 9 Hydbring P....Larsson L.G. (2010)

    External Searches for CDK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1017 HGNC: 1771 AceView: CDK2 Ensembl:ENSG00000123374 euGenes: HUgn1017
    ECgene: CDK2 Kegg: 1017 H-InvDB: CDK2

    Other Databases showing CDK2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk2/

    Intellectual Property
    for CDK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDK2 gene:
    Search GeneIP for patents involving CDK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CDK2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

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