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CDK2 Gene

protein-coding   GIFtS: 78
GCID: GC12P056360

Cyclin-Dependent Kinase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 21 2     EC 2.7.11.223 8
Cell Division Protein Kinase 22 3     Cdc2-Related Protein Kinase2
CDKN22 3     p33(CDK2)2
P33 Protein Kinase2 3     EC 2.7.118

External Ids:    HGNC: 17711   Entrez Gene: 10172   Ensembl: ENSG000001233747   OMIM: 1169535   UniProtKB: P249413   

Export aliases for CDK2 gene to outside databases

Previous GC identifers: GC12M056216 GC12P056923 GC12P056077 GC12P054646 GC12P053399


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK2 Gene:
This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle
regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which
regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S
phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A
or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for CDK2 Gene:
CDK2 (cyclin-dependent kinase 2) is a protein-coding gene. Diseases associated with CDK2 include smooth muscle tumor, and oligodendroglioma. GO annotations related to this gene include histone kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK3.

UniProtKB/Swiss-Prot: CDK2_HUMAN, P24941
Function: Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but
dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2.
Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S
transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2
progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin
B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus.
Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human
embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with
cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin
A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to
mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing.
Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence
by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from
initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this
phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis.
In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated
BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin
E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin
E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated
activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by
being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a
nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S
transition. CTNNB1 phosphorylation regulates insulin internalization

summary for CDK2 Gene:
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through
the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk
genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following
extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D
and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces
transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E
complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M
phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation
of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,
including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by
molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks
is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.
Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to
Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential
targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic
strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK2 (Cyclin-dependent kinase 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDK2 gene promoter:
         C/EBPbeta   Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK2 promoter sequence
   Search Chromatin IP Primers for CDK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13

CDK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056360:  view genomic region     (about GC identifiers)

Start:
56,360,553 bp from pter      End:
56,366,568 bp from pter
Size:
6,016 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDK2_HUMAN, P24941 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 2  
Size: 298 amino acids; 33930 Da
Subunit: Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with
UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and
SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1. Binds to RB1 and CDK7. Binding to CDKN1A (p21) leads
to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S
transition during DNA repair. Associated with PTPN6 and beta-catenin/CTNNB1. Interacts with CACUL1. May interact
with CEP63
Selected PDB 3D structures from and Proteopedia for CDK2 (see all 346):
1AQ1 (3D)        1B38 (3D)        1B39 (3D)        1BUH (3D)        1CKP (3D)        1DI8 (3D)    
Secondary accessions: A8K7C6 O75100
Alternative splicing: 2 isoforms:  P24941-1   P24941-2   

Explore the universe of human proteins at neXtProt for CDK2: NX_P24941

Explore proteomics data for CDK2 at MOPED

Post-translational modifications: 

  • Phosphorylated at Thr-160 by CDK7 in a CAK complex. Phosphorylation at Thr-160 promotes kinase activity, whereas
    phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S
    and G2 phases before being dephosphorylated by CDC25A1
  • Nitrosylated after treatment with nitric oxide (DETA-NO)1
  • Ubiquitination2 at Lys9, Lys56, Lys129, Lys142, Lys237, Lys291
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK2 (P24941) (see all 25)
     VVTLWYR  DFGLARA  EGVPSTA  LADFGLA 


    See CDK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001277159.1  NP_001789.2  NP_439892.2  

    ENSEMBL proteins: 
     ENSP00000266970   ENSP00000450983   ENSP00000452514   ENSP00000393605   ENSP00000452138  
     ENSP00000243067  
    Reactome Protein details: P24941

    CDK2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CDK2 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CDK2
    OriGene Purified Proteins for CDK2
    OriGene Protein Over-expression Lysate for CDK2
    OriGene MassSpec for CDK2
    OriGene Custom Protein Services for CDK2
    GenScript Custom Purified and Recombinant Proteins Services for CDK2
    Novus Biologicals CDK2 Proteins
    Novus Biologicals CDK2 Lysates
    Sino Biological Recombinant Protein for CDK2
    Sino Biological Cell Lysate for CDK2
    ProSpec Recombinant Protein for CDK2
    Cloud-Clone Corp. Proteins for CDK2

    CDK2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK2
    R&D Systems Antibodies for CDK2
    Cell Signaling Technology (CST) Antibodies for CDK2 
    OriGene Antibodies for CDK2
    OriGene Custom Antibody Services for CDK2
    Novus Biologicals CDK2 Antibodies
    Abcam antibodies for CDK2 (P06493, P24941)
    Cloud-Clone Corp. Antibodies for CDK2
    ThermoFisher Antibody for CDK2
    LSBio Antibodies in human, mouse, rat for CDK2

    CDK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK2
    Cloud-Clone Corp. CLIAs for CDK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 2
    CDK1 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P24941

    ProtoNet protein and cluster: P24941

    UniProtKB/Swiss-Prot: CDK2_HUMAN, P24941
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK2_HUMAN, P24941
    Function: Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but
    dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2.
    Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S
    transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2
    progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin
    B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus.
    Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human
    embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with
    cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin
    A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to
    mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing.
    Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence
    by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from
    initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this
    phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis.
    In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated
    BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin
    E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin
    E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated
    activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by
    being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a
    nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S
    transition. CTNNB1 phosphorylation regulates insulin internalization
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160
    activates it. Inhibited by 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), AG-024322,
    N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), R547 (Ro-4584820), purine,
    pyrimidine and pyridine derivatives, 2-aminopyrimidines, paullones, thiazo derivatives, macrocyclic
    quinoxalin-2-one, pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine,
    2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine, seliciclib and CYC202), SNS-032
    (BMS-387032), triazolo[1,5-a]pyrimidines, staurosporine and olomoucine. Stimulated by MYC. Inactivated by CDKN1A
    (p21)
    Induction: Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis

         Genatlas biochemistry entry for CDK2:
    cyclin dependent kinase 2,involved in cell cycle regulation (G1 to S transition),complexing with cyclin E for the
    regulation of chromosome stability,activated in apoptosis by TP53 regulated,BAX and BCL2,putative checkpoint
    between cell cycle and cell death pathway

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10330164
         
    CDK2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDK2:
     Decreased substrate adherent c  Increased cell death HMECs cel  Increased cell number in G2M,   Upregulation of Wnt/beta-caten 

         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cdk2):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  muscle  reproductive system  tumorigenesis  vision/eye 

    CDK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDK2: Cdk2tm1Kald Cdk2tm1Sgo

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK2:
    hsa-mir-361-5p (MIRT044112), hsa-mir-10b-5p (MIRT047445), hsa-mir-23b-3p (MIRT046257), hsa-mir-124-3p (MIRT004283), hsa-mir-26b-5p (MIRT030063), hsa-mir-302d-3p (MIRT005672), hsa-mir-103a-3p (MIRT004764), hsa-mir-376a-3p (MIRT007019), hsa-mir-155-5p (MIRT020948), hsa-mir-885-5p (MIRT005461)

    Block miRNA regulation of human, mouse, rat CDK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK2 (see all 36):
    hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-765 hsa-miR-519a hsa-miR-649 hsa-miR-372 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidCDK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDK2
    Predesigned siRNA for gene silencing in human, mouse, rat CDK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDK2

    Clone
    Products:
         
    OriGene clones in human, mouse for CDK2 (see all 14)
    OriGene ORF clones in mouse, rat for CDK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK2 (NM_052827)
    Sino Biological Human cDNA Clone for CDK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDK2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CDK2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDK2_HUMAN, P24941: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body.
    Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but
    before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by
    1,25-(OH)(2)D(3)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endosome5
    nucleus5
    cytosol4
    extracellular2
    mitochondrion2
    peroxisome2
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000307cyclin-dependent protein kinase holoenzyme complex IDA8692841
    GO:0000781chromosome, telomeric region IEA--
    GO:0000793condensed chromosome IEA--
    GO:0000805X chromosome IEA--
    GO:0000806Y chromosome IEA--

    CDK2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK2 About   (see all 68)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.66
    Cell cycle Start of DNA replication in early S phase0.53
    DNA Replication0.66
    2Cell cycle Regulation of G1 S transition part 2
    Cell cycle Cell cycle generic schema 0.38
    Immune response MIF JAB1 signaling0.32
    Cell cycle Regulation of G1 S transition part 2 0.38
    G2 Phase0.00
    Cell cycle ESR1 regulation of G1 S transition0.33
    3Cyclins and Cell Cycle Regulation
    Cyclins and Cell Cycle Regulation0.67
    Cell Cycle Control by BTG Proteins0.36
    G1-S Phase Transition0.67
    Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes0.00
    4E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    G1 to S cell cycle control0.35
    G1/S Transition0.81
    5Cell cycle
    Cell cycle0.59
    Cell cycle0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CDK2
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDK2 (see all 15)
        Cell Cycle Control by BTG Proteins
    Molecular Mechanisms of Cancer
    Calpain Protease Regulates Cellular Mechanics
    Glioblastoma Multiforme
    DNA Damage Induced 14-3-3Sigma Signaling

    1 Cell Signaling Technology (CST) Pathway for CDK2
        Cell Cycle / Checkpoint Control

    Selected GeneGo (Thomson Reuters) Pathways for CDK2 (see all 11)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Transcription P53 signaling pathway
    Cell cycle Cell cycle (generic schema)
    Cell cycle Role of SCF complex in cell cycle regulation
    Immune response MIF-JAB1 signaling

    Selected BioSystems Pathways for CDK2 (see all 28)
        Cell cycle
    DNA damage response
    G1 to S cell cycle control
    Integrated Breast Cancer Pathway
    Oncostatin M Signaling Pathway

    1 Sino Biological Pathway for CDK2
        p53 Pathway

    Selected Reactome Pathways for CDK2 (see all 17)
        SCF(Skp2)-mediated degradation of p27/p21
    Activation of ATR in response to replication stress
    G0 and Early G1
    Orc1 removal from chromatin
    CDK-mediated phosphorylation and removal of Cdc6


    Selected Kegg Pathways  (Kegg details for CDK2) (see all 14):
        FoxO signaling pathway
    Cell cycle
    Oocyte meiosis
    p53 signaling pathway
    PI3K-Akt signaling pathway


    CDK2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK2 (see all 9): 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK2 (P249411, 2, 3 ENSP000002669704) via UniProtKB, MINT, STRING, and/or I2D (see all 593)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDKN1AP389361, 2, 3, ENSP000002447414EBI-375096,EBI-375077 MINT-2635357 MINT-73323 MINT-3370697 MINT-50415 I2D: score=13 STRING: ENSP00000244741
    CDKN3Q166671, 2, 3, ENSP000003353574EBI-375096,EBI-1031527 MINT-17387 MINT-17388 MINT-24981 I2D: score=6 STRING: ENSP00000335357
    CDKN1BP465271, 2, 3, ENSP000002288724EBI-375096,EBI-519280 MINT-3379700 I2D: score=8 STRING: ENSP00000228872
    CKS1BP610241, 2, 3, ENSP000003110834EBI-375096,EBI-456371 MINT-25066 I2D: score=6 STRING: ENSP00000311083
    CCNB2O950671, 2, 3, ENSP000002882074EBI-375096,EBI-375024 MINT-50430 I2D: score=5 STRING: ENSP00000288207
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000085mitotic G2 phase TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS19238148

    CDK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CDK2
    Selected ApexBio Compounds for CDK2 (see all 20)     About this table
    CompoundAction CAS #
    AT7519novel small molecule effective as a multi-cyclin-dependent kinase inhibitor[844442-38-2]
    AZD-5438Potent CDK1/2/9 inhibitor[602306-29-6]
    BMS265246potent and selective Cdk1/Cdk2 inhibitor[582315-72-8]
    BS-181 HClsmall molecule inhibitor which is highly selective for Cdk7 activity[1397219-81-6]
    Deferasiroxrationally-designed oral iron chelator[201530-41-8]
    Dinaciclib (SCH727965)CDK inhibitor[779353-01-4]
    Flavopiridol hydrochloridepan-cdk inhibitor[131740-09-5]
    LEE011orally available CDK inhibitor[1211441-98-3]
    LY2835219orally available CDK inhibitor, targets the CDK4 and CDK6[1231930-82-7]
    Nu 6027potent inhibitor of cellular ATR activity[220036-08-8]

    Compounds for CDK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 9516Potent cdk2 inhibitor[377090-84-1]
    Purvalanol ACyclin-dependent kinase inhibitor[212844-53-6]
    Ro 3306Cyclin-dependent kinase (cdk) 1 inhibitor[872573-93-8]
    Purvalanol BCyclin-dependent kinase inhibitor[212844-54-7]
    KenpaullonePotent cyclin-dependent kinase inhibitor. Also inhibits GSK-3[142273-20-9]

    2 HMDB Compounds for CDK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected DrugBank Compounds for CDK2 (see all 136)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Hymenialdisine-- --targetinhibitor17139284 11752352 17016423 10592235
    Olomoucine-- 101622-51-9targetinhibitor17139284 11752352 17016423 10592235
    SU9516-- --targetinhibitor17139284 11752352 17016423 10592235
    (2e,3s)-3-Hydroxy-5'-[(4-Hydroxypiperidin-1-Yl)Sulfonyl]-3-Methyl-1,3-Dihydro-2,3'-Biindol-2'(1'h)-One-- --target--17139284 17016423 10592235
    (5-Chloropyrazolo[1,5-a]Pyrimidin-7-Yl)-(4-Methanesulfonylphenyl)Amine-- --target--17139284 17016423 10592235
    1-Amino-6-Cyclohex-3-Enylmethyloxypurine-- --target--17139284 17016423 10592235
    1-[(2-Amino-6,9-Dihydro-1h-Purin-6-Yl)Oxy]-3-Methyl-2-Butanol-- --target--17139284 17016423 10592235
    2-[Trans-(4-Aminocyclohexyl)Amino]-6-(Benzyl-Amino)-9-Cyclopentylpurine-- --target--17139284 17016423 10592235
    3-Pyridin-4-Yl-2,4-Dihydro-Indeno[1,2-.C.]Pyrazole-- --target--17139284 17016423 10592235
    3-[4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for CDK2 gene (see all 158)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    roscovitine 89.5 102 9030780 (4), 9288122 (4), 9841966 (3), 16575928 (3) (see all 66)
    olomoucine 86.5 42 9288122 (4), 9841966 (3), 10234573 (3), 11896531 (2) (see all 25)
    nu2058 82 16 19426695 (6), 17599054 (2), 10956187 (1), 14657672 (1)
    fascaplysin 80.2 2 16750360 (1), 10973815 (1)
    flavopiridol 78.8 26 8674031 (3), 15185335 (2), 11289134 (2), 12852762 (2) (see all 19)
    nu6102 78 3 15928920 (2), 19426695 (1)
    su9516 77.4 11 12234612 (4), 11507069 (2), 14550307 (2), 12749903 (1)
    7-hydroxystaurosporine 71 3 10665655 (1), 15715961 (1), 12181445 (1)
    purvalanol 67.7 4 16168436 (1), 16733081 (1), 16140252 (1)
    aminopurvalanol 66.6 1 10220373 (1)



    CDK2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for CDK2 gene (3 alternative transcripts): 
    NM_001290230.1  NM_001798.4  NM_052827.3  

    Unigene Cluster for CDK2:

    Cyclin-dependent kinase 2
    Hs.19192  [show with all ESTs]
    Unigene Representative Sequence: NM_001798
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266970(uc001sit.4 uc001siu.4 uc010spy.2) ENST00000556464
    ENST00000555408 ENST00000553376 ENST00000440311 ENST00000555357 ENST00000354056
    ENST00000554619 ENST00000556276 ENST00000556656 ENST00000556146 ENST00000554545

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK2 (see all 36):
    hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-765 hsa-miR-519a hsa-miR-649 hsa-miR-372 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidCDK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDK2
    Predesigned siRNA for gene silencing in human, mouse, rat CDK2
    Clone
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    OriGene clones in human, mouse for CDK2 (see all 14)
    OriGene ORF clones in mouse, rat for CDK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK2 (NM_052827)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK2
    Primer
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    OriGene qPCR primer pairs and template standards for CDK2
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK2
      QuantiTect SYBR Green Assays in human, mouse, rat CDK2
      QuantiFast Probe-based Assays in human, mouse, rat CDK2

    Additional mRNA sequence: 

    AB012305.1 AK291941.1 AK293246.1 BC003065.2 BT006821.1 M68520.1 X61622.1 X62071.1 

    15 DOTS entries:

    DT.95327485  DT.92441495  DT.99990963  DT.313922  DT.91866813  DT.95107346  DT.95326857  DT.100893294 
    DT.121208040  DT.92441489  DT.92441490  DT.75102502  DT.92436457  DT.95190554  DT.97862514 

    Selected AceView cDNA sequences (see all 232):

    BX324447 BU172812 BQ217507 AA463909 BX336328 AA810989 BI093689 BQ230342 
    CR603533 AU119029 BX343446 BQ220088 CR610978 BX375699 AL121503 BU174856 
    BQ215672 BQ925355 BX397060 AU139504 BE535195 BQ434863 AU131320 BQ049334 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
    SP1:                          -     -     -     -                                                   
    SP2:                          -     -     -     -                       -                           
    SP3:                                            -                                                   
    SP4:                          -     -     -     -                       -                           
    SP5:                                      -     -                                                   


    ECgene alternative splicing isoforms for CDK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACCTTGG
    CDK2 Expression
    About this image


    CDK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Thymus (Hematopoietic System)
    CDK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.19192
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK2 (see all 9): 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat
              Breast Cancer in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Primer
    Products:
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    OriGene qSTAR qPCR primer pairs in human, mouse for CDK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK2
    QuantiTect SYBR Green Assays in human, mouse, rat CDK2
    QuantiFast Probe-based Assays in human, mouse, rat CDK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK2 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk21 , 5 cyclin-dependent kinase 21, 5 92.51(n)1
    98.99(a)1
      10 (77.13 cM)5
    125661  NM_183417.31  NP_904326.11 
     1286979395 
    chicken
    (Gallus gallus)
    Aves CDK21 cyclin-dependent kinase 2 79.75(n)
    93.29(a)
      100529062  NM_001199857.1  NP_001186786.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK26
    cyclin-dependent kinase 2
    93(a)
    1 ↔ 1
    GL343198.1(3371512-3386011)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.42272 X. laevis Eg1 mRNA for serine/threonine kinase (cdc2) more 78.65(n)    X14227.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.178832 Danio rerio cDNA clone MGC56598 IMAGE5915295, complete more 76.04(n)    BC049499.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cdc23
    cdc2c1
    G2/M transition of mitotic cell cycle
    protein more3
    cdc2c1
    64(a)
    (best of 3)3
    62.81(n)1
    65.65(a)1
      31D113
    424531  NM_169916.31  NP_732544.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-13 serine/threonine kinase (CDC2/CDKX
    subfamily)
    60(a)
    (best of 3)
      III(9819189-9820383)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC28(YBR160W)4
    CDC281
    Catalytic subunit of the main cell cycle cyclin-dependent more4
    CDC281
    61.37(n)1
    65.37(a)1
      2(560078-560974)4
    8524571, 4  NP_009718.31  NP_009718.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CDC21 CDC2 63.21(n)
    68.86(a)
      824036  NM_114734.3  NP_566911.1 
    rice
    (Oryza sativa)
    Liliopsida Os.34282 O.sativa Rcdc2-2 gene for p34-cdc2 protein kinase 77.16(n)    AK101344.1 


    ENSEMBL Gene Tree for CDK2 (if available)
    TreeFam Gene Tree for CDK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK2 gene
    CDK32  CDK62  CDK42  CDK12  
    Selected SIMAP similar genes for CDK2 using alignment to 4 protein entries:     CDK2_HUMAN (see all proteins) (see all similar genes):
    CDK3    MAP4K2    MAP4K3    MAP4K5    STK4    CDK18
    CDK1    CDC2    STK11    CDK17    CDKL4    CDK11A
    CDK14    CDK16    CDK11B    CDC2L1    DKFZp686L20222    CDKL1

    CDK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK2 (see all 71)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419724
    A glioblastoma multiforme sample4--see VAR_0419722 P L mis40--------
    rs1128570841,2
    C,F--56362506(+) GAGCAC/AACCCA 2 -- int11Minor allele frequency- A:0.50CSA 4
    rs20694031,2
    C,F--56362943(+) gaggtG/Aggagg 2 -- int13Minor allele frequency- A:0.01NA NS CSA 362
    rs1492352621,2
    --56362958(+) CTTGAG/TCCCAG 2 -- int10--------
    rs20694041,2
    C,F--56362991(+) acataG/Acgaga 2 -- int14Minor allele frequency- A:0.05NA NS CSA WA 480
    rs20694051,2
    C,F--56362998(+) gagacC/Accatc 2 -- int13Minor allele frequency- A:0.09NA NS EA 480
    rs574889501,2
    C--56363078(+) AAGATC/TTCAAA 2 -- int12Minor allele frequency- T:0.02WA 120
    rs731232181,2
    C,F--56363222(+) ACCCTA/GTAAAC 2 -- int12Minor allele frequency- G:0.01NA EU 697
    rs2004363621,2
    --56363231(+) ACCACC/TCCGCC 2 -- int10--------
    rs2019523291,2
    C--56363324(+) GCTGTC/GGACAT 3 V int1 syn10--------

    HapMap Linkage Disequilibrium report for CDK2 (56360553 - 56366568 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832424CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK2
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116953    OMIM disorders: --

    Selected diseases for CDK2 (see all 118):    
    About MalaCards
    smooth muscle tumor    oligodendroglioma    pancreatic ductal carcinoma    uterine sarcoma
    male germ cell tumor    anaplastic oligodendroglioma    balanitis    arteriovenous fistula
    cervical intraepithelial neoplasia    laryngeal squamous cell carcinoma    leiomyoma    primary effusion lymphoma
    laryngitis    leiomyosarcoma    pemphigus vulgaris    seminoma
    malignant peripheral nerve sheath tumor    melanoma    retinoblastoma    gastric ulcer

    4 diseases from the University of Copenhagen DISEASES database for CDK2:
    Retinoblastoma     Breast cancer     Carcinoma     Leukemia

    CDK2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CDK2 gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 89.6 154 7954429 (2), 9103470 (2), 16824683 (2), 9492054 (2) (see all 99)
    cancer 66.2 103 20423616 (4), 12888290 (2), 16740735 (2), 19525400 (2) (see all 72)
    tumors 61.5 155 11585414 (4), 11299721 (3), 12352662 (3), 10995786 (2) (see all 99)
    breast cancer 53.6 77 8867812 (3), 20010939 (3), 17671085 (3), 10995786 (2) (see all 46)
    colon cancer 50.1 4 12920809 (1), 15763423 (1), 10216486 (1), 12676582 (1)
    prostate cancer 48.7 22 20147522 (3), 9492054 (2), 12954644 (2), 11062725 (1) (see all 12)
    prostate carcinoma 47 3 9794232 (1), 11052627 (1), 12352461 (1)
    colon carcinoma 41 3 7601562 (1), 12234612 (1), 11052627 (1)
    carcinoma squamous cell 35.5 15 11710944 (2), 10390005 (2), 11267947 (1), 11676482 (1) (see all 12)
    pancreatic cancer 35.5 5 9841966 (1), 11376563 (1), 15084985 (1), 19639215 (1) (see all 5)

    Genetic Association Database (GAD): CDK2
    Human Genome Epidemiology (HuGE) Navigator: CDK2 (14 documents)
    Tumor Gene Database (TGDB): CDK2

    Export disorders for CDK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK2 gene, integrated from 10 sources (see all 1905):
    (articles sorted by number of sources associating them with CDK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation. (PubMed id 1717994)1, 2, 3, 9 Ninomiya-Tsuji J.... Matsumoto K. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition. (PubMed id 20147522)1, 2, 9 Flores O.... Burnstein K.L. (Endocrinology 2010)
    3. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. (PubMed id 1396589)1, 2, 9 Gu Y.... O'Morgan D.O. (EMBO J. 1992)
    4. Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. (PubMed id 11113184)1, 2, 9 Garrett S.... Fisher R.P. (Mol. Cell. Biol. 2001)
    5. High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design. (PubMed id 8917641)1, 2, 9 Schulze-Gahmen U.... Kim S.-H. (J. Med. Chem. 1996)
    6. Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. (PubMed id 8275715)1, 3, 9 Demetrick D.J....Beach D.H. (Cytogenet. Cell Genet. 1994)
    7. Cdk2 nitrosylation and loss of mitochondrial potential mediate NO- dependent biphasic effect on HL-60 cell cycle. (PubMed id 20079829)1, 2, 9 Kumar S.... Dikshit M. (Free Radic. Biol. Med. 2010)
    8. Cyclin B and cyclin A confer different substrate recognition properties on CDK2. (PubMed id 17495531)1, 2, 9 Brown N.R....Johnson L.N. (Cell Cycle 2007)
    9. Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value. (PubMed id 19594747)1, 4, 9 Jardin F....Tilly H. (Br. J. Haematol. 2009)
    10. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. (PubMed id 10499802)1, 2, 9 Harbour J.W.... Dean D.C. (Cell 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1017 HGNC: 1771 AceView: CDK2 Ensembl:ENSG00000123374 euGenes: HUgn1017
    ECgene: CDK2 Kegg: 1017 H-InvDB: CDK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdk2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK2 gene:
    Search GeneIP for patents involving CDK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK2
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     EMD Millipore Purified and/or Recombinant CDK2 Protein
     
     EMD Millipore genomic analysis products

      
     Antibodies for CDK2 (CDK2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
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     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CDK2   OriGene RNAi products in human, mouse, rat for CDK2  
     OriGene qPCR primer pairs and template standards for CDK2   OriGene Protein Over-expression Lysate for CDK2  
     OriGene MassSpec something-or-other for CDK2   OriGene clones in human, mouse for CDK2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDK2   OriGene Purified Protein for CDK2  
     OriGene ORF clones in mouse, rat for CDK2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDK2   OriGene Custom Protein Services for CDK2  

     
     
     Block miRNA regulation of human, mouse, rat CDK2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CDK2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK2 Predesigned siRNA for gene silencing in human, mouse, rat CDK2
     QuantiFast Probe-based Assays in human, mouse, rat CDK2 QuantiTect SYBR Green Assays in human, mouse, rat CDK2
     PCR Arrays including human, mouse, rat CDK2 Search Chromatin IP Primers for CDK2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK2  GeneGlobe Interaction Network for CDK2
     Regulatory tfbs in CDK2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CDK2 GenScript cDNA clones with any tag delivered in your preferred vector for CDK2
     GenScript Custom Assay Services for CDK2 GenScript Custom overexpressing Cell Line Services for CDK2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for CDK2 

     Tocris compounds for CDK2
     Proteins for CDK2
     Cell Lysates for CDK2
     cDNA Clones for CDK2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for CDK2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CDK2 antibodies
     CDK2 proteins
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     Antibodies for CDK2
     See all of Abcam's Antibodies, Kits and Proteins for CDK2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CDK2
     Proteins for CDK2
     Antibodies for CDK2
     ELISAs for CDK2
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     Browse ESI BIO Cell Lines and PureStem Progenitors for CDK2
     Gene Synthesis
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     Variant Library Synthesis
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK2
     SwitchGear 3'UTR luciferase reporter plasmids for CDK2
     SwitchGear Promoter luciferase reporter plasmids for CDK2
     ThermoFisher Antibody for CDK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK2
     LSBio Antibodies in human, mouse, rat for CDK2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for CDK2
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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