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CDK2 Gene

protein-coding GIFtS: 72

GC12P054646

cyclin-dependent kinase 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.22 ^³
p33(CDK2) ^²

Descriptions
cdc2-related protein kinase ^²
cell devision kinase 2 ^²
cyclin-dependent kinase 2 ^²
p33 protein kinase ^², ³

External Ids
HGNC: 1771¹
Entrez Gene: 1017²
UniProtKB: P24941³
Ensembl: ENSG00000123374⁷

Search outside databases for aliases for CDK2 gene

Previous GC identifers: GC12M056216 GC12P056923 GC12P056077

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CDK2:

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein

kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a

catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to

the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with

and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor

p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein

phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of

this gene have been reported. [provided by RefSeq]

UniProtKB/Swiss-Prot: CDK2_HUMAN, P24941

Function: Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E.

Activity of CDK2 is maximal during S phase and G2

Gene Wiki entry for CDK2 (Cyclin-dependent_kinase_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDK2 gene

Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13

CDK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P054646: (about GC identifiers)

Start:	54,646,826 bp from pter
End:	54,652,835 bp from pter
Size:	6,010 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_029419.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CDK2_HUMAN, P24941 (See protein sequence)

Recommended Name: Cell division protein kinase 2

Size: 298 amino acids; 33930 Da

Subunit: Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity).

Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the

Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1

PDB structures from and Proteopedia :

1AQ1 (3D)

1B38 (3D)

1B39 (3D)

1BUH (3D)

1CKP (3D)

1DI8 (3D)

1DM2 (3D)

1E1V (3D)

1E1X (3D)

1E9H (3D)

1F5Q (3D)

1FIN (3D)

1FQ1 (3D)

1FVT (3D)

1FVV (3D)

1G5S (3D)

1GIH (3D)

1GII (3D)

1GIJ (3D)

1GY3 (3D)

1GZ8 (3D)

1H00 (3D)

1H01 (3D)

1H07 (3D)

1H08 (3D)

1H0V (3D)

1H0W (3D)

1H1P (3D)

1H1Q (3D)

1H1R (3D)

1H1S (3D)

1H24 (3D)

1H25 (3D)

1H26 (3D)

1H27 (3D)

1H28 (3D)

1HCK (3D)

1HCL (3D)

1JST (3D)

1JSU (3D)

1JSV (3D)

1JVP (3D)

1KE5 (3D)

1KE6 (3D)

1KE7 (3D)

1KE8 (3D)

1KE9 (3D)

1OGU (3D)

1OI9 (3D)

1OIQ (3D)

1OIR (3D)

1OIT (3D)

1OIU (3D)

1OIY (3D)

1OKV (3D)

1OKW (3D)

1OL1 (3D)

1OL2 (3D)

1P2A (3D)

1P5E (3D)

1PF8 (3D)

1PKD (3D)

1PW2 (3D)

1PXI (3D)

1PXJ (3D)

1PXK (3D)

1PXL (3D)

1PXM (3D)

1PXN (3D)

1PXO (3D)

1PXP (3D)

1PYE (3D)

1QMZ (3D)

1R78 (3D)

1URC (3D)

1URW (3D)

1V1K (3D)

1VYW (3D)

1VYZ (3D)

1W0X (3D)

1W8C (3D)

1W98 (3D)

1WCC (3D)

1Y8Y (3D)

1Y91 (3D)

1YKR (3D)

2A0C (3D)

2A4L (3D)

2B52 (3D)

2B53 (3D)

2B54 (3D)

2B55 (3D)

2BHE (3D)

2BHH (3D)

2BKZ (3D)

2BPM (3D)

2BTR (3D)

2BTS (3D)

2C4G (3D)

2C5N (3D)

2C5O (3D)

2C5P (3D)

2C5V (3D)

2C5X (3D)

2C5Y (3D)

2C68 (3D)

2C69 (3D)

2C6I (3D)

2C6K (3D)

2C6L (3D)

2C6M (3D)

2C6O (3D)

2C6T (3D)

2CCH (3D)

2CCI (3D)

2CJM (3D)

2CLX (3D)

2DS1 (3D)

2DUV (3D)

2EXM (3D)

2FVD (3D)

2G9X (3D)

2HIC (3D)

2I40 (3D)

2IW6 (3D)

2IW8 (3D)

2IW9 (3D)

2J9M (3D)

2JGZ (3D)

2R3F (3D)

2R3G (3D)

2R3H (3D)

2R3I (3D)

2R3J (3D)

2R3K (3D)

2R3L (3D)

2R3M (3D)

2R3N (3D)

2R3O (3D)

2R3P (3D)

2R3Q (3D)

2R3R (3D)

2R64 (3D)

2UUE (3D)

2UZB (3D)

2UZD (3D)

2UZE (3D)

2UZL (3D)

2UZN (3D)

2UZO (3D)

2V0D (3D)

2V22 (3D)

2VTA (3D)

2VTH (3D)

2VTI (3D)

2VTJ (3D)

2VTL (3D)

2VTM (3D)

2VTN (3D)

2VTO (3D)

2VTP (3D)

2VTQ (3D)

2VTR (3D)

2VTS (3D)

2VTT (3D)

2VU3 (3D)

2VV9 (3D)

2W05 (3D)

2W06 (3D)

2W17 (3D)

2W1H (3D)

3BHT (3D)

3BHU (3D)

3BHV (3D)

3DDP (3D)

3DDQ (3D)

3DOG (3D)

3EID (3D)

3EJ1 (3D)

3EOC (3D)

3EZR (3D)

3EZV (3D)

3F5X (3D)

3FZ1 (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001789.2 NP_439892.2

ENSEMBL proteins:

ENSP00000266970 ENSP00000243067

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CDK2
	Millipore Purified and/or Recombinant CDK2 Protein
	Sigma-Aldrich Proteins and CompoZr ZFN for CDK2
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CDK2
	Recombinant Proteins from Abcam (Cdk1 + Cdk2, CDK2 + Cyclin A2, Cdk2, Cdks)
	Human Recombinant Proteins from Abnova (CDK2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IDA	8692841
GO:0005634	nucleus	IDA	16109376
GO:0005654	nucleoplasm	EXP	1396589 7629134 9840943 10323868 10339564 10454565 10548110 11231585 11340163 11907280 11931757 15226314 15707391
GO:0005737	cytoplasm	TAS	10767298
GO:0005829	cytosol	EXP	1312467 7799941 9840943 11907280

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Antibodies for CDK2:

	Invitrogen Antibodies for CDK2
	Millipore Mono- and Polyclonal Antibodies for the study of CDK2
	Sigma-Aldrich Antibodies for CDK2
	R&D Systems Antibodies for CDK2
	Cell Signaling Technology (CST) Antibodies for CDK2
	Antibodies from Abcam (Cdk1 + Cdk2, CDK2 + Cyclin A2, Cdk2, Cdks), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CDK2)
	Novus Biologicals Antibodies for CDK2

Assays for CDK2:

	Invitrogen Assays for CDK2
	Millipore Kits and Assays for the Analysis of CDK2
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P24941

ProtoNet protein and cluster: P24941

UniProtKB/Swiss-Prot: CDK2_HUMAN, P24941

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.

CDC2/CDKX subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDK2)
		Millipore RNAi Products for the Analysis of CDK2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDK2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_052827

Applied Biosystems Silencer® siRNAs for CDK2

Sigma-Aldrich siRNA and siRNA Panels for CDK2

Sigma-Aldrich shRNA Panels and shRNA for CDK2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CDK2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001798
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001798
untagged cDNA clones in CMV expression vector (see all 5): NM_001798

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001798

UniProtKB/Swiss-Prot: CDK2_HUMAN, P24941

Function: Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E.

Activity of CDK2 is maximal during S phase and G2

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while

phosphorylation at Thr-160 activates it

Enzyme Number (IUBMB): EC 2.7.11.22

Genatlas biochemistry entry for CDK2:

cyclin dependent kinase 2,involved in cell cycle regulation (G1 to S transition),complexing with

cyclin E for the regulation of chromosome stability,activated in apoptosis by TP53 regulated,BAX

and BCL2,putative checkpoint between cell cycle and cell death pathway

15 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cdk2):

	cellular	embryogenesis	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-prenatal/perinatal	liver/biliary system
muscle	no phenotypic analysis	reproductive system	skin/coat/nails	vision/eye

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004693	cyclin-dependent protein kinase activity	TAS	1653904
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--
GO:0035173	contributes to histone kinase activity	IDA	8692841

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/13 Sigma-Aldrich "Your Favorite Gene" Pathways for CDK2 (Your Favorite Gene powered by Ingenuity) (see all 13 )

p53 Signaling
ATM Signaling
Nicotinate and Nicotinamide Metabolism
Cell Cycle Regulation by BTG Family Proteins
Small Cell Lung Cancer Signaling

GeneDecks CDK2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CDK2

5/274 Interacting proteins for CDK2 (ENSP00000266970³ P24941^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 274 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCNE2	O96020¹	STRING (score=.999) EBI-375096, EBI-375033
RB1	P06400¹	STRING (score=.999) EBI-375096, EBI-491274
UHRF2	Q96PU4¹	STRING (score=.944) EBI-375096, EBI-625304
EP300	Q09472²	STRING (score=.927) MINT-2983422 MINT-2983397 MINT-2983446 MINT-2983372
CKS1B	P61024²	STRING (score=.999) MINT-25066

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	TAS	1653904
GO:0006275	regulation of DNA replication	TAS	9933170
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007049	cell cycle	IEA	--
GO:0007067	mitosis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CDK2

Sigma-Aldrich Small Molecules for CDK2:

Inhibitor

Compounds for CDK2 available from Tocris Bioscience

Compound	Action	CAS number
SU 9516	Potent cdk2 inhibitor	[377090-84-1]
Olomoucine	Cyclin-dependent kinase inhibitor	[101622-51-9]
Purvalanol B	Cyclin-dependent kinase inhibitor	[212844-54-7]
NU 2058	Cdk1 and cdk2 inhibitor	[161058-83-9]
Purvalanol A	Cyclin-dependent kinase inhibitor	[212844-53-6]

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10/59 Novoseek chemical compound relationships for CDK2 gene (see all 59 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fascaplysin	81.22	2	16750360 (1), 10973815 (1)
nu2058	80.83	14	19426695 (6), 17599054 (2), 10956187 (1), 14657672 (1)
su9516	78.86	11	12234612 (4), 11507069 (2), 14550307 (2), 12749903 (1)
nu6102	75.20	3	15928920 (2), 19426695 (1)
purvalanol	69.04	4	16168436 (1), 16733081 (1), 16140252 (1)
aminopurvalanol	67.38	1	10220373 (1)
kenpaullone	66.37	3	10363974 (1), 17224799 (1)
gnidimacrin	62.30	5	11745413 (5)
mimosine	61.65	2	8940249 (1), 10788489 (1)
threonine	58.78	40	8393783 (3), 10931829 (2), 8647814 (1), 9845759 (1) (see all 28)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDK2)
		Millipore RNAi Products for the Analysis of CDK2 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CDK2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_052827

Sigma-Aldrich siRNA and siRNA Panels for CDK2

Sigma-Aldrich shRNA Panels and shRNA for CDK2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001798 NM_052827

REFSEQ mRNAs for CDK2 gene (2 alternative transcripts):

NM_001798.3 NM_052827.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001798 NM_052827

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001798
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001798
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001798

Additional cDNA sequence:

AB012305.1 AK291941.1 AK293246.1 BC003065.2 BT006821.1 CR603533.1 CR610978.1 M68520.1

X61622.1 X62071.1

15 DOTS entries:

DT.95327485 DT.92441495 DT.99990963 DT.91866813 DT.313922 DT.95107346 DT.95326857 DT.100893294

DT.121208040 DT.92441489 DT.92441490 DT.75102502 DT.92436457 DT.95190554 DT.97862514

24/232 AceView cDNA sequences (see all 232 ):

CB129784 BQ434863 BX375699 BU172812 CR610978 BX343446 BQ217507 BQ421647

BQ925355 BX324447 AA463909 BQ215672 BU174856 BQ220088 BX397060 AU119029

AU139504 BE535195 CR603533 BQ049334 CB112879 AA810989 AL121503 BI093689

highest scoring ESTs for CDK2:

M68520 AA256937 AA418475 AB012305 AI088528 AI554848 AI989454 AL121503 AU119029 AW375951

Unigene Cluster for CDK2:

Cyclin-dependent kinase 2

Hs.19192 [show with all ESTs]

Unigene Representative Sequence: NM_001798

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDK2 (see all 7 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9
SP1:									-		-		-		-
SP2:									-		-		-		-								-
SP3:															-
SP4:									-		-		-		-								-
SP5:													-		-

About this scheme

ECgene alternative splicing isoforms for CDK2

2 Ensembl transcripts including schematic representations:

ENST00000266970 ENST00000354056

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CDK2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDK2

¹ / ² / ³

9 probe-sets matching CDK2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1792_g_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.11	M68520	1.00	1.00	1.00	1
74635_at²^{, 3}	U95-D	1	1.00	1.00	0.97	1.14	AI989454	0.80	1.00	0.91	1
1833_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.75	M68520	1.00	1.00	1.00	1
211804_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB012305	0.80	1.00	0.91	1
204252_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M68520	1.00	1.00	1.00	1
211803_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB012305	0.80	1.00	0.91	1
211804_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204252_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211803_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CDK2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCAACAAATC

SOURCE GeneReport for Unigene cluster: Hs.19192
Expression variation in blood from EXPOLDB for CDK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDK2 gene from 5/25 species (see all 25 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDK2¹	--	cyclin-dependent kinase 2	93.29(n) 98.99(a)	606931 XM_843254.1 XP_848347.1
chimpanzee (Pan troglodytes)	CDK2¹	--	cyclin-dependent kinase 2	99.89(n) 100(a)	467032 XM_522432.2 XP_522432.2
cow (Bos taurus)	CDK2¹	--	cyclin-dependent kinase 2	93.62(n) 98.66(a)	519217 NM_001014934.1 NP_001014934.1
rat (Rattus norvegicus)	Cdk2¹	--	cyclin dependent kinase 2	91.5(n) 98.99(a)	362817 NM_199501.1 NP_955795.1
mouse (Mus musculus)	Cdk2^{1, 5}	10⁵	cyclin-dependent kinase 2^{1, 5}	92.51(n)¹ 98.99(a)¹	12566¹ NM_183417.2¹ NP_904326.1¹ AA414699⁵ AJ223732⁵ (see all 33)

About this table Species with no ortholog for CDK2

ENSEMBL Gene Tree for CDK2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDK2 gene

CDK3² CDC2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/27 NCBI SNPs in CDK2 are shown (see all 27 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 53)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2069413^1,2	C,F,H	54651648(+)	`TGTGAC/GCAAGC`	2	T/S	mis¹		7	NA EU EA WA NS	2254
	rs2069414^1,2	C,F,H	54651966(+)	`aaaGCC/ATTCCT`	2	--	ut3¹		10	NA EU EA WA NS	1090
	rs2069406^1,2	C,F,H	54649624(+)	`GCTGAG/AATGGT`	2	E/E	syn¹ int¹		14	NA EU EA WA NS	1490
	rs2069408^1,2	A,C,F,H	54650588(+)	`CCCCCA/GGTGCA`	2	--	int¹		20	NA EU EA WA NS	2090
	rs3213122^1,2	C,F,H	54649933(+)	`TAGTGC/ACTCTT`	2	--	int¹		11	NS EU EA WA	1074
	rs2069409^1,2	C,F,H	54650611(+)	`TGTCCG/ATATTC`	2	--	int¹		6	NA EU EA WA NS	770
	rs2069410^1,2	C,F,H	54650912(+)	`GGGGCG/AAGGAG`	2	--	int¹		16	NA EU EA WA NS	1660
	rs2069411^1,2	C,F,H	54651004(+)	`CTGACC/TTTTTA`	2	--	int¹		6	NA EU EA WA NS	764
	rs2069412^1,2	C,F,H	54651552(+)	`AGTCAA/GCATGC`	2	--	int¹		6	NA EA WA NS	806
	rs2069402^1,2	C,F,H	54648619(+)	`TTTTTC/TAATGC`	2	--	int¹		3	NA WA NS	466

About this table

HapMap Linkage Disequilibrium images for CDK2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 116953

10/94 Novoseek disease relationships for CDK2 gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	89.64	141	7954429 (2), 9103470 (2), 16824683 (2), 9492054 (2) (see all 99)
cancer	64.25	83	12888290 (2), 16740735 (2), 18698751 (2), 12676582 (2) (see all 58)
tumors	60.67	138	11585414 (4), 11299721 (3), 12352662 (3), 10995786 (2) (see all 96)
breast cancer	51.96	67	8867812 (3), 17671085 (3), 10995786 (2), 15572662 (2) (see all 41)
prostate carcinoma	48.50	3	9794232 (1), 11052627 (1), 12352461 (1)
colon cancer	48.29	4	12920809 (1), 15763423 (1), 10216486 (1), 12676582 (1)
prostate cancer	45.31	16	9492054 (2), 12954644 (2), 11062725 (1), 16970927 (1) (see all 10)
colon carcinoma	42.80	3	7601562 (1), 12234612 (1), 11052627 (1)
carcinoma squamous cell	35.59	15	11710944 (2), 10390005 (2), 11267947 (1), 11676482 (1) (see all 12)
pancreatic cancer	34.13	3	9841966 (1), 11376563 (1), 15084985 (1)

About this table

Human Genome Epidemiology Navigator: CDK2 (8 documents)
Tumor Gene Database: CDK2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1453 PubMed articles for CDK2 gene (see all 1453 ):

Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation. (PubMed id 1717994)^{1, 2, 3, 4} Ninomiya-Tsuji J.... Matsumoto K. (1991)
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. (PubMed id 1396589)^{1, 3, 4} Gu Y.... O'Morgan D.O. (1992)
High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design. (PubMed id 8917641)^{1, 3, 4} Schulze-Gahmen U.... Kim S.-H. (1996)
Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. (PubMed id 8275715)^{1, 2, 3} Demetrick D.J....Beach D.H. (1994)
Cyclin B and cyclin A confer different substrate recognition properties on CDK2. (PubMed id 17495531)^{1, 3, 4} Brown N.R....Johnson L.N. (2007)
Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin. (PubMed id 12185076)^{1, 3, 4} Nguyen T.B....Koff A. (2002)
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. (PubMed id 8684460)^{1, 3, 4} Russo A.A.... Pavletich N.P. (1996)
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. (PubMed id 8610110)^{1, 3, 4} de Azevedo W.F. Jr.... Kim S.-H. (1996)
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1. (PubMed id 1714386)^{1, 3, 4} Elledge S.J. and Spottswood M.R. (1991)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1017	HGNC: 1771	AceView: CDK2	Ensembl:ENSG00000123374	euGenes: HUgn1017
ECgene: CDK2	H-InvDB: CDK2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for CDK2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/cdk2/

Licensable Technologies for CDK2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CDK2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CDK2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CDK2		Antibodies for CDK2
	Explore super-pooled esiRNAs		Proteins for CDK2
	Lentivirus-delivered shRNAs for CDK2		Small molecules for CDK2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CDK2)
	Antibodies (CDK2)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CDK2

	Recombinant Proteins (Cdk1 + Cdk2, CDK2 + Cyclin A2, Cdk2, Cdks)
	Antibodies (Cdk1 + Cdk2, CDK2 + Cyclin A2, Cdk2, Cdks)

Search OriGene for CDK2

Tocris compounds for CDK2

	Drugs/Proteins for CDK2
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CDK2

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CDK2 Gene

protein-coding GIFtS: 72

Aliases &
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Genomic Location
for CDK2

Proteins
for CDK2

Protein Domains/
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for CDK2

Gene Function
for CDK2

Pathways & Interactions
for CDK2

Drugs & Compounds
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDK2 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor CDK2

Summariesfor CDK2

Genomic Locationfor CDK2

Proteinsfor CDK2

Protein Domains/Familiesfor CDK2

Gene Functionfor CDK2

Pathways & Interactionsfor CDK2

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Expression for CDK2

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SNPs/Variantsfor CDK2

Disorders & Mutationsfor CDK2

Medical Newsfor CDK2

Publicationsfor CDK2

Search for CDK2

Genome Databases showing CDK2

Other Databases showing CDK2

Specialized Databases showing CDK2

Licensable Technologiesfor CDK2

Servicesfor CDK2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CDK2

Summaries
for CDK2

Genomic Location
for CDK2

Proteins
for CDK2

Protein Domains/
Families
for CDK2

Gene Function
for CDK2

Pathways & Interactions
for CDK2

Drugs & Compounds
for CDK2

Transcripts
for CDK2

Expression
for CDK2

Orthologs
for CDK2

Paralogs
for CDK2

SNPs/Variants
for CDK2

Disorders & Mutations
for CDK2

Medical News
for CDK2

Publications
for CDK2

Licensable Technologies
for CDK2

Services
for CDK2