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Aliases for CDK2 Gene

Aliases for CDK2 Gene

  • Cyclin Dependent Kinase 2 2 3 5
  • Cell Division Protein Kinase 2 3 4
  • P33 Protein Kinase 3 4
  • EC 2.7.11.22 4 61
  • CDKN2 3 4
  • CDC2-Related Protein Kinase 3
  • Cyclin-Dependent Kinase 2 3
  • P33(CDK2) 3
  • EC 2.7.11 61

External Ids for CDK2 Gene

Previous GeneCards Identifiers for CDK2 Gene

  • GC12M056216
  • GC12P056923
  • GC12P056077
  • GC12P054646
  • GC12P056360
  • GC12P053399

Summaries for CDK2 Gene

Entrez Gene Summary for CDK2 Gene

  • This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

CIViC summary for CDK2 Gene

GeneCards Summary for CDK2 Gene

CDK2 (Cyclin Dependent Kinase 2) is a Protein Coding gene. Diseases associated with CDK2 include Glioblastoma Multiforme and Glioblastoma. Among its related pathways are DNA Double-Strand Break Repair and Regulation of TP53 Activity. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK3.

UniProtKB/Swiss-Prot for CDK2 Gene

  • Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431).

Tocris Summary for CDK2 Gene

  • Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle.

Gene Wiki entry for CDK2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK2 Gene

Genomics for CDK2 Gene

Regulatory Elements for CDK2 Gene

Enhancers for CDK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G056718 1.5 ENCODE dbSUPER 29.2 +755.8 755790 8.9 CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 ZNF263 MCM3 NEMP1 SMARCC2 BAZ2A ENSG00000257740 ANKRD52 TMEM198B ENSG00000224713 NAB2 RN7SL809P STAT2
GH12G056298 1.4 ENCODE dbSUPER 30 +334.0 334042 4.6 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 NEMP1 BAZ2A ZC3H10 CDK2 RN7SL809P ENSG00000257303 TMEM198B RPL41 RNU6-343P RBMS2
GH12G055715 1.7 Ensembl ENCODE dbSUPER 21.6 -248.1 -248098 7.1 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 BAZ2A RDH5 RN7SL809P ENSG00000258199 CDK2 ITGA7 TMEM198B RNU6-343P ZC3H10 ENSG00000257740
GH12G056040 1.7 FANTOM5 ENCODE dbSUPER 18.4 +75.2 75231 3.3 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 BAZ2A RN7SL809P ENSG00000258199 STAT2 SUOX RAB5B ENSG00000257740 GDF11 RBMS2 PHC1P1
GH12G055742 1.3 ENCODE dbSUPER 21.6 -222.3 -222343 4.6 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 YBX1 ZNF2 ZBTB7B ZNF143 CDK2 BAZ2A RN7SL809P TMEM198B RNU6-343P ZC3H10 SUOX ITGA7 BLOC1S1 ORMDL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDK2 on UCSC Golden Path with GeneCards custom track

Promoters for CDK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052462 231 1201 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Transcription factor binding sites by QIAGEN in the CDK2 gene promoter:

Genomic Location for CDK2 Gene

Chromosome:
12
Start:
55,966,769 bp from pter
End:
55,972,789 bp from pter
Size:
6,021 bases
Orientation:
Plus strand

Genomic View for CDK2 Gene

Genes around CDK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK2 Gene

Proteins for CDK2 Gene

  • Protein details for CDK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24941-CDK2_HUMAN
    Recommended name:
    Cyclin-dependent kinase 2
    Protein Accession:
    P24941
    Secondary Accessions:
    • A8K7C6
    • O75100

    Protein attributes for CDK2 Gene

    Size:
    298 amino acids
    Molecular mass:
    33930 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Found in a complex with CABLES1, CCNA1 and CCNE1. Interacts with CABLES1 (By similarity). Interacts with UHRF2. Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts with the Speedy/Ringo proteins SPDYA and SPDYC. Found in a complex with both SPDYA and CDKN1B/KIP1. Binds to RB1 and CDK7. Binding to CDKN1A (p21) leads to CDK2/cyclin E inactivation at the G1-S phase DNA damage checkpoint, thereby arresting cells at the G1-S transition during DNA repair. Associated with PTPN6 and beta-catenin/CTNNB1. Interacts with CACUL1. May interact with CEP63. Interacts with ANKRD17. Interacts with CEBPA (when phosphorylated) (PubMed:15107404). Forms a ternary complex with CCNA2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements (PubMed:8684460). Interacts with cyclins A, B1, B3, D, or E (PubMed:10499802, PubMed:10884347, PubMed:12185076, PubMed:23781148). Interacts with CDK2AP2 (PubMed:23781148).

    Three dimensional structures from OCA and Proteopedia for CDK2 Gene

    Alternative splice isoforms for CDK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK2 Gene

Selected DME Specific Peptides for CDK2 Gene

P24941:
  • GCIFAEM
  • FCHSHRV
  • TAIREIS
  • DVIHTENKL
  • YSTAVDIWSLGCIFAEM
  • DFGLARA
  • YDPNKRISAK
  • EVVTLWYRAP
  • RVLHRDLKPQNLLIN
  • VVTLWYR
  • EGVPSTA
  • LADFGLA
  • DLKKFMD
  • VLHRDLK
  • DFGLARAFG
  • SEIDQLF
  • WPGVTSMPDYKPSFPKWARQD
  • HRDLKPQN
  • RISAKAAL
  • FQKVEKIGEGTYGVVYKA
  • VALKKIR
  • SKVVPPLDEDGR
  • IGEGTYG
  • NHPNIVKL
  • KLYLVFE

Post-translational modifications for CDK2 Gene

  • Nitrosylated after treatment with nitric oxide (DETA-NO).
  • Phosphorylated at Thr-160 by CDK7 in a CAK complex. Phosphorylation at Thr-160 promotes kinase activity, whereas phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity. Phosphorylated on Thr-14 and Tyr-15 during S and G2 phases before being dephosphorylated by CDC25A.
  • Ubiquitination at posLast=66, posLast=5656, posLast=129129, Lys142, posLast=237237, and posLast=291291
  • Modification sites at PhosphoSitePlus

Domains & Families for CDK2 Gene

Gene Families for CDK2 Gene

Protein Domains for CDK2 Gene

Suggested Antigen Peptide Sequences for CDK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P24941

UniProtKB/Swiss-Prot:

CDK2_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK2: view

Function for CDK2 Gene

Molecular function for CDK2 Gene

GENATLAS Biochemistry:
cyclin dependent kinase 2,involved in cell cycle regulation (G1 to S transition),complexing with cyclin E for the regulation of chromosome stability,activated in apoptosis by TP53 regulated,BAX and BCL2,putative checkpoint between cell cycle and cell death pathway
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-160 activates it. Inhibited by 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), AG-024322, N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), R547 (Ro-4584820), purine, pyrimidine and pyridine derivatives, 2-aminopyrimidines, paullones, thiazo derivatives, macrocyclic quinoxalin-2-one, pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine, 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine, seliciclib and CYC202), SNS-032 (BMS-387032), triazolo[1,5-a]pyrimidines, staurosporine and olomoucine. Stimulated by MYC. Inactivated by CDKN1A (p21).
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (PubMed:12944431).
UniProtKB/Swiss-Prot Induction:
Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis.

Enzyme Numbers (IUBMB) for CDK2 Gene

Gene Ontology (GO) - Molecular Function for CDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI 2227411
genes like me logo Genes that share ontologies with CDK2: view
genes like me logo Genes that share phenotypes with CDK2: view

Animal Models for CDK2 Gene

MGI Knock Outs for CDK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK2

CRISPR Products

miRNA for CDK2 Gene

miRTarBase miRNAs that target CDK2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK2 Gene

Localization for CDK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
endosome 5
plasma membrane 2
extracellular 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA 1312467
GO:0000781 chromosome, telomeric region IEA --
GO:0000793 condensed chromosome IEA --
GO:0000805 X chromosome IEA --
GO:0000806 Y chromosome IEA --
genes like me logo Genes that share ontologies with CDK2: view

Pathways & Interactions for CDK2 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 DNA Double-Strand Break Repair
3 Cyclins and Cell Cycle Regulation
4 E2F mediated regulation of DNA replication
5 Cell cycle Cell cycle (generic schema)
.01
genes like me logo Genes that share pathways with CDK2: view

Gene Ontology (GO) - Biological Process for CDK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006260 DNA replication TAS 19238148
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with CDK2: view

Drugs & Compounds for CDK2 Gene

(278) Drugs for CDK2 Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
bosutinib Approved Pharma Target, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Deferasirox Approved, Investigational Pharma Oral iron chelator 89
Bosulif Approved September 2012 Pharma 0
Flavopiridol Experimental, Investigational Pharma Target, inhibitor Pan-cdk inhibitor 0
Purvalanol A Experimental Pharma 0

(66) Additional Compounds for CDK2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PD 0332991 isethionate
827022-33-3

(5) Tocris Compounds for CDK2 Gene

Compound Action Cas Number
BMS 265246 Potent cdk1/2 inhibitor 582315-72-8
Kenpaullone Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3 142273-20-9
PD 0332991 isethionate Potent, selective Cdk4/6 inhibitor; brain penetrant 827022-33-3
Ro 3306 Cyclin-dependent kinase (cdk) 1 inhibitor 872573-93-8
Senexin A Cyclin-dependent kinase 8 (cdk8) inhibitor

(35) ApexBio Compounds for CDK2 Gene

Compound Action Cas Number
A-674563 Akt1/PKA/CDK2 inhibitor,potent and selective 552325-73-2
Aminopurvalanol A 220792-57-4
AT7519 Multi-CDK inhibitor 844442-38-2
AT7519 Hydrochloride Multi-CDK inhibitor 902135-91-5
AT7519 trifluoroacetate CDK/cyclin inhibitor 1431697-85-6
AZD-5438 Potent CDK1/2/9 inhibitor 602306-29-6
AZD-5597 Potent CDK inhibitor 924641-59-8
BMS265246 CDK1/2 inhibitor,potent and selective 582315-72-8
BS-181 HCl CDK7 inhibitor,highly selective 1397219-81-6
CDK inhibitor II 1269815-17-9
CVT-313 Cdk2 inhibitor 199986-75-9
Deferasirox Oral iron chelator 201530-41-8
Dinaciclib (SCH727965) Potent CDK inhibitor 779353-01-4
Flavopiridol Pan-cdk inhibitor 146426-40-6
Flavopiridol hydrochloride 131740-09-5
JNJ-7706621 Potent CDK/Aurora kinase inhibitor 443797-96-4
Kenpaullone 142273-20-9
LDC000067 1073485-20-7
NSC 625987 141992-47-4
Nu 6027 ATR/CDK inhibitor, potent and selective 220036-08-8
NVP-LCQ195 CDK1/CDK2/CDK5 inhibitor 902156-99-4
PF 4800567 hydrochloride 1391052-28-0
PF-562271 ATP-competitive FAK inhibitor, reversible 717907-75-0
PHA-793887 Pan-Cdk inhibitor 718630-59-2
PHA-848125 CDK inhibitor,potent and ATP-competitive 802539-81-7
Purvalanol A 212844-53-6
Purvalanol B CDK1/CDK2/CDK4 inhibitor 212844-54-7
R547 CDK1/2/4 inhibitor,ATP-competitive 741713-40-6
Roscovitine (Seliciclib,CYC202) CDK inhibitor,potent and selective 186692-46-6
SB1317 CDK,JAK and FLT inhibitor 937270-47-8
SCH900776 S-isomer Checkpoint kinase(Chk)inhibitor 891494-64-7
SNS-032 (BMS-387032) CDK inhibitor 345627-80-7
SU 9516 Cdk2 inhibitor 377090-84-1
TMCB 905105-89-7
WHI-P180 hydrochloride inhibitor of Cdk2, EGFR and Janus Kinase 3 153437-55-9
genes like me logo Genes that share compounds with CDK2: view

Drug Products

Transcripts for CDK2 Gene

Unigene Clusters for CDK2 Gene

Cyclin-dependent kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDK2

Alternative Splicing Database (ASD) splice patterns (SP) for CDK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - - - -
SP5: - -
SP6:
SP7: - - - - -

Relevant External Links for CDK2 Gene

GeneLoc Exon Structure for
CDK2
ECgene alternative splicing isoforms for
CDK2

Expression for CDK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDK2 Gene

This gene is overexpressed in Breast (12.5), Peripheral blood mononuclear cells (10.7), Lymph node (9.2), and Fetal gut (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK2 Gene



Protein tissue co-expression partners for CDK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK2 Gene:

CDK2

SOURCE GeneReport for Unigene cluster for CDK2 Gene:

Hs.19192

Evidence on tissue expression from TISSUES for CDK2 Gene

  • Skin(4.1)
  • Intestine(2.8)
  • Nervous system(2.8)
  • Lung(2.7)
  • Liver(2.6)
  • Blood(2.5)
  • Muscle(2.5)
  • Bone marrow(2.3)
  • Kidney(2.3)
  • Lymph node(2.1)
  • Heart(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with CDK2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK2 Gene

Orthologs for CDK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK2 34 35
  • 99.89 (n)
cow
(Bos Taurus)
Mammalia CDK2 34 35
  • 93.62 (n)
dog
(Canis familiaris)
Mammalia CDK2 34 35
  • 93.29 (n)
mouse
(Mus musculus)
Mammalia Cdk2 34 16 35
  • 92.51 (n)
rat
(Rattus norvegicus)
Mammalia Cdk2 34
  • 91.5 (n)
chicken
(Gallus gallus)
Aves CDK2 34 35
  • 79.75 (n)
lizard
(Anolis carolinensis)
Reptilia CDK2 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk2 34
  • 77.36 (n)
Str.2871 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4227 34
zebrafish
(Danio rerio)
Actinopterygii cdk2 34 35
  • 75.84 (n)
Dr.17883 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9226 34
fruit fly
(Drosophila melanogaster)
Insecta cdc2 36
  • 64 (a)
cdc2c 36 34 35
  • 62.81 (n)
Cdk4 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004579 34
  • 60.94 (n)
worm
(Caenorhabditis elegans)
Secernentea cdk-1 36
  • 60 (a)
cdk-2 35
  • 40 (a)
ManyToMany
cdk-4 36
  • 38 (a)
H01G02.2 36
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR058C 34
  • 63.3 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC28 34 35 37
  • 61.37 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B09790g 34
  • 59.7 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons CDC2 34
  • 63.21 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6720 34
rice
(Oryza sativa)
Liliopsida Os03g0118400 34
  • 64.71 (n)
Os.3428 34
barley
(Hordeum vulgare)
Liliopsida Hv.10992 34
corn
(Zea mays)
Liliopsida Zm.12226 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5702 35
  • 67 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU09778 34
  • 64.98 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc2 34
  • 61.69 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5905 34
Species where no ortholog for CDK2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK2 Gene

ENSEMBL:
Gene Tree for CDK2 (if available)
TreeFam:
Gene Tree for CDK2 (if available)

Paralogs for CDK2 Gene

Variants for CDK2 Gene

Sequence variations from dbSNP and Humsavar for CDK2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_041972 A glioblastoma multiforme sample
rs1000506207 -- 55,967,895(+) AGAGA(C/T)CTCTC intron-variant, upstream-variant-2KB, reference, missense
rs1000568856 -- 55,972,446(+) AGAAG(C/G/T)TAGGG upstream-variant-2KB, utr-variant-3-prime
rs1001293184 -- 55,966,775(+) ACGCG(A/G)GAAGC upstream-variant-2KB, utr-variant-5-prime
rs1001728800 -- 55,972,321(+) GGCCT(C/T)ATGAG upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDK2 Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv832424 CNV loss 17160897

Variation tolerance for CDK2 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK2 Gene

Human Gene Mutation Database (HGMD)
CDK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK2 Gene

Disorders for CDK2 Gene

MalaCards: The human disease database

(23) MalaCards diseases for CDK2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glioblastoma multiforme
  • adult glioblastoma multiforme
glioblastoma
  • glioblastoma multiforme
sensory system cancer
retinal cancer
  • malignant neoplasm of retina
star syndrome
  • toe syndactyly, telecanthus, and anogenital and renal malformations
- elite association - COSMIC cancer census association via MalaCards
Search CDK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDK2

Genetic Association Database (GAD)
CDK2
Human Genome Epidemiology (HuGE) Navigator
CDK2
Tumor Gene Database (TGDB):
CDK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK2