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Aliases for CDK19 Gene

Aliases for CDK19 Gene

  • Cyclin-Dependent Kinase 19 2 3
  • Cell Division Cycle 2-Like Protein Kinase 6 3 4
  • Cell Division Cycle 2-Like 6 (CDK8-Like) 2 3
  • Cyclin-Dependent Kinase (CDC2-Like) 11 2 3
  • Cell Division Protein Kinase 19 3 4
  • CDC2-Related Protein Kinase 6 3 4
  • Cyclin-Dependent Kinase 11 3 4
  • Death-Preventing Kinase 3 4
  • KIAA1028 4 6
  • CDC2L6 3 4
  • CDK11 3 4
  • Cyclin Dependent Kinase 19 Variant 2 3
  • CDK8-Like Cyclin-Dependent Kinase 3
  • EC 2.7.11.22 4
  • BA346C16.3 3
  • EC 2.7.11 64

External Ids for CDK19 Gene

Previous Symbols for CDK19 Gene

  • CDK11
  • CDC2L6

Summaries for CDK19 Gene

Entrez Gene Summary for CDK19 Gene

  • This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for CDK19 Gene

CDK19 (Cyclin-Dependent Kinase 19) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK8.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK19 Gene

Genomics for CDK19 Gene

Genomic Location for CDK19 Gene

Start:
110,609,978 bp from pter
End:
110,815,958 bp from pter
Size:
205,981 bases
Orientation:
Minus strand

Genomic View for CDK19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK19 Gene

No data available for Regulatory Elements for CDK19 Gene

Proteins for CDK19 Gene

  • Protein details for CDK19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWU1-CDK19_HUMAN
    Recommended name:
    Cyclin-dependent kinase 19
    Protein Accession:
    Q9BWU1
    Secondary Accessions:
    • Q5JQZ7
    • Q5JR00
    • Q8TC78
    • Q9UPX2

    Protein attributes for CDK19 Gene

    Size:
    502 amino acids
    Molecular mass:
    56802 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH24247.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK19 Gene

Proteomics data for CDK19 Gene at MOPED

Selected DME Specific Peptides for CDK19 Gene

Post-translational modifications for CDK19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK19 Gene

Domains for CDK19 Gene

Gene Families for CDK19 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

UniProtKB/Swiss-Prot:

CDK19_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9BWU1
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.:
    • Q9BWU1
genes like me logo Genes that share domains with CDK19: view

Function for CDK19 Gene

Molecular function for CDK19 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for CDK19 Gene

Gene Ontology (GO) - Molecular Function for CDK19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK19: view
genes like me logo Genes that share phenotypes with CDK19: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK19 Gene

Localization for CDK19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK19 Gene COMPARTMENTS Subcellular localization image for CDK19 gene
Compartment Confidence
cytoskeleton 1
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CDK19 Gene

Pathways for CDK19 Gene

genes like me logo Genes that share pathways with CDK19: view

Gene Ontology (GO) - Biological Process for CDK19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDK19: view

Compounds for CDK19 Gene

(2) HMDB Compounds for CDK19 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with CDK19: view

Transcripts for CDK19 Gene

Unigene Clusters for CDK19 Gene

Cyclin-dependent kinase 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK19 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2: - -
SP3:

Relevant External Links for CDK19 Gene

GeneLoc Exon Structure for
CDK19
ECgene alternative splicing isoforms for
CDK19

Expression for CDK19 Gene

mRNA expression in normal human tissues for CDK19 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK19 Gene

SOURCE GeneReport for Unigene cluster for CDK19 Gene Hs.744895

genes like me logo Genes that share expressions with CDK19: view

Orthologs for CDK19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK19 36
  • 99.85 (n)
  • 100 (a)
CDK19 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK19 36
  • 94.07 (n)
  • 98.2 (a)
CDK19 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK19 36
  • 92.45 (n)
  • 97.17 (a)
CDK19 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk19 36
  • 90.35 (n)
  • 96.61 (a)
Cdk19 16
Cdk19 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK19 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK19 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk19 36
  • 90.82 (n)
  • 96.61 (a)
chicken
(Gallus gallus)
Aves CDK19 36
  • 85.4 (n)
  • 93.46 (a)
CDK19 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK19 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cdk-8-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk19 36
  • 81.09 (n)
  • 88.98 (a)
zebrafish
(Danio rerio)
Actinopterygii cdk19 36
  • 74.91 (n)
  • 89.1 (a)
cdk19 37
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cdk8 37
  • 72 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdk-8 37
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSN3 37
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CDKE;1 36
  • 51.98 (n)
  • 47.25 (a)
rice
(Oryza sativa)
Liliopsida Os10g0580300 36
  • 54.77 (n)
  • 50.44 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6555 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 81 (a)
OneToMany
Species with no ortholog for CDK19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDK19 Gene

ENSEMBL:
Gene Tree for CDK19 (if available)
TreeFam:
Gene Tree for CDK19 (if available)

Paralogs for CDK19 Gene

Paralogs for CDK19 Gene

genes like me logo Genes that share paralogs with CDK19: view

Variants for CDK19 Gene

Sequence variations from dbSNP and Humsavar for CDK19 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs10624 -- 110,610,228(+) TGCGT(G/T)CAGAA utr-variant-3-prime
rs706928 -- 110,806,849(+) ggtat(A/G)tgcct intron-variant
rs706929 -- 110,807,396(+) AATGA(C/T)TGCCC intron-variant
rs706930 -- 110,809,699(+) CGTTT(G/T)TAAAG intron-variant
rs802657 -- 110,778,458(+) TATGT(C/T)ATCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK19 Gene

Variant ID Type Subtype PubMed ID
nsv830770 CNV Loss 17160897
nsv830772 CNV Gain 17160897
nsv886537 CNV Gain 21882294
esv2672817 CNV Deletion 23128226
esv2732571 CNV Deletion 23290073
nsv823823 CNV Loss 20364138
nsv516177 CNV Loss 19592680
nsv886538 CNV Gain 21882294
esv2670731 CNV Deletion 23128226
esv268054 CNV Insertion 20981092
nsv830773 CNV Loss 17160897

Relevant External Links for CDK19 Gene

HapMap Linkage Disequilibrium report
CDK19

Disorders for CDK19 Gene

Relevant External Links for CDK19

Genetic Association Database (GAD)
CDK19
Human Genome Epidemiology (HuGE) Navigator
CDK19
genes like me logo Genes that share disorders with CDK19: view

No data available for UniProtKB/Swiss-Prot for CDK19 Gene

Publications for CDK19 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for CDK19 Gene

  • Addgene plasmids for CDK19

Sources for CDK19 Gene

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