Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK19 Gene

protein-coding   GIFtS: 58
GCID: GC06M110932

Cyclin-Dependent Kinase 19

(Previous names: cyclin-dependent kinase (CDC2-like) 11, cell division cycle...)
(Previous symbols: CDK11, CDC2L6)
  Search for CDK19
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 191 2     Death-Preventing Kinase2 3
CDC2L61 2 3     CDC2-Related Protein Kinase 62 3
CDK111 2 3     bA346C16.32
Cell Division Cycle 2-Like 6 (CDK8-Like)1 2     CDK8-Like Cyclin-Dependent Kinase2
Cyclin-Dependent Kinase (CDC2-Like) 111 2     Cyclin Dependent Kinase 19 Variant 22
Cell Division Cycle 2-Like Protein Kinase 62 3     EC 2.7.11.223
Cell Division Protein Kinase 192 3     KIAA10283
Cyclin-Dependent Kinase 112 3     EC 2.7.118

External Ids:    HGNC: 193381   Entrez Gene: 230972   Ensembl: ENSG000001551117   OMIM: 6147205   UniProtKB: Q9BWU13   

Export aliases for CDK19 gene to outside databases

Previous GC identifers: GC06M111039 GC06M108502


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK19 Gene:
This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator
complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of
genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8
which can also be a component of the Mediator complex. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDK19 Gene: 
CDK19 (cyclin-dependent kinase 19) is a protein-coding gene. Among its related super-pathways are Axon guidance. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is CDK8.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK19
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK19 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

CDK19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK19 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M110932:  view genomic region     (about GC identifiers)

Start:
110,931,181 bp from pter      End:
111,137,161 bp from pter
Size:
205,981 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK19_HUMAN, Q9BWU1 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 19  
Size: 502 amino acids; 56802 Da
Sequence caution: Sequence=AAH24247.1; Type=Erroneous initiation;
Secondary accessions: Q5JQZ7 Q5JR00 Q8TC78 Q9UPX2
Alternative splicing: 2 isoforms:  Q9BWU1-1   Q9BWU1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK19: NX_Q9BWU1

Explore proteomics data for CDK19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BWU1

  • 2 DME Specific Peptides for CDK19 (Q9BWU1)
     VLHRDLK  YRAPELLL 

    CDK19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK19 Protein Expression
    REFSEQ proteins: NP_055891.1  
    ENSEMBL proteins: 
     ENSP00000357907   ENSP00000317665   ENSP00000415621   ENSP00000434476   ENSP00000410604  
    Reactome Protein details: Q9BWU1
    Human Recombinant Protein Products for CDK19: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CDK19
    OriGene Protein Over-expression Lysate for CDK19
    OriGene MassSpec for CDK19 
    OriGene Custom Protein Services for CDK19
    GenScript Custom Purified and Recombinant Proteins Services for CDK19
    Novus Biologicals CDK19 Proteins
    Novus Biologicals CDK19 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK19 


    CDK19 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CDK19
    GenScript Custom Superior Antibodies Services for CDK19
    Novus Biologicals CDK19 Antibodies
    Abcam antibodies for CDK19
    Cloud-Clone Corp. Antibodies for CDK19 
    ThermoFisher Antibody for CDK19
    LSBio Antibodies in human, mouse, rat for CDK19 

    Assay Products for CDK19: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK19
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK19
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK19 
    Cloud-Clone Corp. CLIAs for CDK19


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 19 
    CDK8 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9BWU1

    ProtoNet protein and cluster: Q9BWU1

    UniProtKB/Swiss-Prot: CDK19_HUMAN, Q9BWU1
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK19_HUMAN, Q9BWU1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.221

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    CDK19 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDK19:
     Decreased substrate adherent c  Increased cell death HMECs cel  Increased colony dispersion (i 

         1 MGI phenotypic allele for Cdk19 (no phenotypes)

    CDK19 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK19 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK19 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK19 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK19:
    hsa-mir-373 (MIRT003832)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK19
    8/111 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK19 (see all 111):
    hsa-miR-607 hsa-miR-520f hsa-miR-520e hsa-miR-361-5p hsa-miR-376b hsa-miR-218-1* hsa-miR-374a hsa-miR-4275
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK19

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDK19
    Sirion Biotech Customized adenovirus for overexpression of CDK19

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDK19 (see all 8)
    OriGene ORF clones in mouse, rat for CDK19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDK19 (NM_015076)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK19
    Sirion Biotech Customized lentivirus for stable overexpression of CDK19 
                         Customized lentivirus expression plasmids for stable overexpression of CDK19 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDK19
    Search LifeMap BioReagents cell lines for CDK19
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK19


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK19 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Developmental Biology0.69
    2Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for CDK19
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation



    CDK19 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/82 Interacting proteins for CDK19 (Q9BWU13 ENSP000003579074) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRSF7Q166293, ENSP000003259054I2D: score=3 STRING: ENSP00000325905
    EIF3FO003033, ENSP000003100404I2D: score=2 STRING: ENSP00000310040
    MED1Q156483, ENSP000003006514I2D: score=2 STRING: ENSP00000300651
    MED10Q9BTT43, ENSP000002557644I2D: score=2 STRING: ENSP00000255764
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0051301cell division ----

    CDK19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK19

    2 HMDB Compounds for CDK19    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about CDK19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK19 gene: 
    NM_015076.3  

    Unigene Cluster for CDK19:

    Cyclin-dependent kinase 19
    Hs.744895  [show with all ESTs]
    Unigene Representative Sequence: NM_015076
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368911(uc003puh.1) ENST00000323817(uc011eax.1 uc003pui.1)
    ENST00000457688 ENST00000463016 ENST00000460913 ENST00000468997 ENST00000497709
    ENST00000413605
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK19
    8/111 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK19 (see all 111):
    hsa-miR-607 hsa-miR-520f hsa-miR-520e hsa-miR-361-5p hsa-miR-376b hsa-miR-218-1* hsa-miR-374a hsa-miR-4275
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK19
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK19
    Clone
    Products:
         
    OriGene clones in human, mouse for CDK19 (see all 8)
    OriGene ORF clones in mouse, rat for CDK19
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDK19 (NM_015076)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK19
    Sirion Biotech Customized lentivirus for stable overexpression of CDK19 
                         Customized lentivirus expression plasmids for stable overexpression of CDK19 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK19
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK19
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK19
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK19

    Additional mRNA sequence: 

    AB028951.2 AK292360.1 AK300567.1 AL122055.1 AY028424.1 BC024247.1 BC037289.1 JX028238.1 

    11 DOTS entries:

    DT.214139  DT.92425193  DT.92425189  DT.95262826  DT.121357094  DT.121356903  DT.107663  DT.102834469 
    DT.97840418  DT.92425190  DT.95262828 

    24/188 AceView cDNA sequences (see all 188):

    AA339816 BU619550 NM_015076 AI078052 AA428200 AA043107 AI472152 AA649134 
    BM832778 AA460757 AI085029 BM975293 AA906375 BX503685 BC047513 BQ023376 
    AA039402 BQ185177 BQ574452 AI278439 AI680597 H90375 AA312952 Z38518 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CDK19    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:        -     -     -                                                                                       
    SP2:                    -     -                                                                                 
    SP3:                                                                                                            


    ECgene alternative splicing isoforms for CDK19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTGCAGGA
    CDK19 Expression
    About this image


    See CDK19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK19

    SOURCE GeneReport for Unigene cluster: Hs.744895
        SABiosciences Custom PCR Arrays for CDK19
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK19
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK19
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK19
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK19
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK19 gene from 10/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk191 , 5 cyclin-dependent kinase 191, 5 90.35(n)1
    96.61(a)1
      10 (21.94 cM)5
    783341  NM_001168304.11  NP_001161776.11 
     403493085 
    chicken
    (Gallus gallus)
    Aves CDK191 cyclin-dependent kinase 19 84.31(n)
    92.26(a)
      421756  XM_419786.3  XP_419786.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDK196
    cyclin-dependent kinase 19
    95(a)
    1 ↔ 1
    1(191837089-191977741)
    African clawed frog
    (Xenopus laevis)
    Amphibia cdk-8-prov2 Cyclin-Dependent Kinase (67.8 kD) (cdk-8) 80.51(n)    BC056076.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk191 cyclin-dependent kinase 19 75.56(n)
    90.21(a)
      100149670  XM_001923318.3  XP_001923353.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk86
    Cyclin-dependent kinase 8
    72(a)
    1 → many
    3L(9830180-9831791)
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-86
    Cyclin-dependent kinase 8
    44(a)
    1 → many
    I(8702478-8705796)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSN36
    Cyclin-dependent protein kinase, component of RNA ...
    27(a)
    1 → many
    XVI(473040-474707)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CDKE;11 cyclin-dependent kinase E-1 52.61(n)
    47.49(a)
      836481  NM_125756.4  NP_201166.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g05803001 hypothetical protein 51.31(n)
    45.35(a)
      4349519  NM_001072044.1  NP_001065512.1 


    ENSEMBL Gene Tree for CDK19 (if available)
    TreeFam Gene Tree for CDK19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK19 gene
    CDK82  
    18/50 SIMAP similar genes for CDK19 using alignment to 5 protein entries:     CDK19_HUMAN (see all proteins) (see all similar genes):
    DKFZp434M058    CDK8    MAPK8    STK36    STK25    CDK11B
    CDK10    CDK16    MAPK7    CDK3    CDK6    CDC2L1
    CDC2L2    DKFZp564L2416    MAK    CDKL1    CDK4    NLK

    CDK19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3745 SNPs in CDK19 are shown (see all 3745)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs567108191,2
    C--108690359(+) AAAAA-/A/AAA 
     AAAAAAA
    GAAAG
    1 -- int12NA 4
    rs2019588191,2
    C--110931078(+) TTCTA-/CCTC  
      AGCCTC
    CCGAA
    1 -- ds50010--------
    rs2014302441,2
    C--110931080(+) CTACC-/TCAGCCTC 1 -- ds50010--------
    rs1999721641,2
    C--110931084(+) CTCAG-/CCTCCC
            
    GAAGT
    1 -- ds50010--------
    rs2011464661,2
    C--110931091(+) TCCCGA/GAGTGC 1 -- ds50010--------
    rs3703073631,2
    C--110931094(+) CGAAG-/TGCTGA 1 -- ds50010--------
    rs21406721,2
    C,F,A,H--110931135(+) ACTAAA/GCCTTA 1 -- ds500121Minor allele frequency- G:0.34NS EA NA WA CSA 1010
    rs1814952891,2
    --110931260(+) ATTTCA/CAGAAG 1 -- ut310--------
    rs117549351,2
    H--110931337(+) GAGCAG/AGCCTC 1 -- ut314Minor allele frequency- A:0.00NS EA 420
    rs1410838431,2
    --110931387(+) AGCACA/GAAAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CDK19 (110931181 - 111137161 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for CDK19 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2732571CNV Deletion23290073
    esv2672817CNV Deletion23128226
    esv2670731CNV Deletion23128226
    esv268054CNV Insertion20981092
    nsv516177CNV Loss19592680
    nsv830770CNV Loss17160897
    nsv823823CNV Loss20364138
    nsv830773CNV Loss17160897
    nsv830772CNV Gain17160897
    nsv886538CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK19
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDK19 for disorders           About MalaCards
    OMIM gene information: 614720    OMIM disorders: --


    CDK19 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDK19
    Human Genome Epidemiology (HuGE) Navigator: CDK19 (2 documents)

    Export disorders for CDK19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK19 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with CDK19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    7. A conserved Mediator-CDK8 kinase module association re gulates Mediator-RNA polymerase II interaction. (PubMed id 23563140)1 Tsai K.L....Asturias F.J. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    10. Mediator CDK subunits are platforms for interactions w ith various chromatin regulatory complexes. (PubMed id 22668559)1 Fukasawa R....Ohkuma Y. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23097 HGNC: 19338 AceView: CDK11 Ensembl:ENSG00000155111 euGenes: HUgn23097
    ECgene: CDK19 H-InvDB: CDK19

    (According to HUGE)
    About This Section
    HUGE: KIAA1028

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK19 gene:
    Search GeneIP for patents involving CDK19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CDK19  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CDK19  
     OriGene MassSpec something-or-other for CDK19   OriGene clones in human, mouse for CDK19  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDK19   OriGene Purified Protein for CDK19  
     OriGene ORF clones in mouse, rat for CDK19   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDK19   OriGene Custom Protein Services for CDK19  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK19
     QIAGEN SeqTarget long-range PCR primers for resequencing CDK19
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK19
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK19
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK19
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK19
     GenScript Custom Purified and Recombinant Proteins Services for CDK19 GenScript cDNA clones with any tag delivered in your preferred vector for CDK19
     GenScript Custom Assay Services for CDK19 GenScript Custom Superior Antibodies Services for CDK19
     GenScript Custom overexpressing Cell Line Services for CDK19 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for CDK19
     Search Chromatin IP Primers for CDK19
     RT2 qPCR Primer Assay in human, mouse, rat CDK19
     Search GNC Networks for CDK19
     SABiosciences Custom PCR Arrays for CDK19
     Search Tocris compounds for CDK19
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CDK19 antibodies
     CDK19 proteins
     CDK19 lysates
     Antibodies for CDK19
     See all of Abcam's Antibodies, Kits and Proteins for CDK19
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CDK19
     Antibodies for CDK19
     ELISAs for CDK19
     CLIAs for CDK19
     Search LifeMap BioReagents cell lines for CDK19
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK19
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CDK19
     SwitchGear Promoter luciferase reporter plasmids for CDK19
     ThermoFisher Antibody for CDK19
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK19
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK19
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK19
    Customized:
     lentivirus for stable overexpression of CDK19
     lentivirus expression plasmids for stable overexpression of CDK19
     adenovirus for overexpression of CDK19
     LSBio Antibodies in human, mouse, rat for CDK19
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDK19 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4