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CDK19 Gene

protein-coding   GIFtS: 56
GCID: GC06M110932

Cyclin-Dependent Kinase 19

(Previous names: cyclin-dependent kinase (CDC2-like) 11, cell division cycle...)
(Previous symbols: CDK11, CDC2L6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cyclin-Dependent Kinase 191 2     Death-Preventing Kinase2 3
CDC2L61 2 3     CDC2-Related Protein Kinase 62 3
CDK111 2 3     KIAA10283 5
Cell Division Cycle 2-Like 6 (CDK8-Like)1 2     bA346C16.32
Cyclin-Dependent Kinase (CDC2-Like) 111 2     CDK8-Like Cyclin-Dependent Kinase2
Cell Division Cycle 2-Like Protein Kinase 62 3     Cyclin Dependent Kinase 19 Variant 22
Cell Division Protein Kinase 192 3     EC 2.7.11.223
Cyclin-Dependent Kinase 112 3     EC 2.7.118

External Ids:    HGNC: 193381   Entrez Gene: 230972   Ensembl: ENSG000001551117   OMIM: 6147205   UniProtKB: Q9BWU13   
ORGUL members:         

Export aliases for CDK19 gene to outside databases

Previous GC identifers: GC06M111039 GC06M108502


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK19 Gene:
This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator
complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of
genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8
which can also be a component of the Mediator complex. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDK19 Gene:
CDK19 (cyclin-dependent kinase 19) is a protein-coding gene. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK8.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CDK19
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK19 promoter sequence
   Search Chromatin IP Primers for CDK19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

CDK19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK19 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M110932:  view genomic region     (about GC identifiers)

Start:
110,931,181 bp from pter      End:
111,137,161 bp from pter
Size:
205,981 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDK19_HUMAN, Q9BWU1 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 19  
Size: 502 amino acids; 56802 Da
Sequence caution: Sequence=AAH24247.1; Type=Erroneous initiation;
Secondary accessions: Q5JQZ7 Q5JR00 Q8TC78 Q9UPX2
Alternative splicing: 2 isoforms:  Q9BWU1-1   Q9BWU1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK19: NX_Q9BWU1

Explore proteomics data for CDK19 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for CDK19 (Q9BWU1)
     VLHRDLK  YRAPELLL 


    See CDK19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055891.1  
    ENSEMBL proteins: 
     ENSP00000357907   ENSP00000317665   ENSP00000415621   ENSP00000434476   ENSP00000410604  
    Reactome Protein details: Q9BWU1

    CDK19 Human Recombinant Protein Products:

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    Novus Biologicals CDK19 Proteins
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    Cloud-Clone Corp. Proteins for CDK19

     
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    CDK19 Assay Products:

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    Search eBioscience for ELISAs for CDK19 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 19
    CDK8 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9BWU1

    ProtoNet protein and cluster: Q9BWU1

    UniProtKB/Swiss-Prot: CDK19_HUMAN, Q9BWU1
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDK19           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK19_HUMAN, Q9BWU1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.221

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CDK19           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDK19:
     Decreased substrate adherent c  Increased cell death HMECs cel  Increased colony dispersion (i 

         1 MGI phenotypic allele for Cdk19 (no phenotypes)

    Find genes that share phenotypes with CDK19           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK19
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK19
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    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK19:
    hsa-mir-21-5p (MIRT030820), hsa-mir-148a-3p (MIRT026007), hsa-mir-128-3p (MIRT021943), hsa-mir-335-5p (MIRT017357), hsa-mir-373-3p (MIRT003832), hsa-mir-130b-3p (MIRT020239), hsa-mir-20a-5p (MIRT050601), hsa-mir-19b-3p (MIRT031144), hsa-mir-26b-5p (MIRT029199), hsa-mir-10a-5p (MIRT047678)

    Block miRNA regulation of human, mouse, rat CDK19 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK19 (see all 111):
    hsa-miR-607 hsa-miR-520f hsa-miR-520e hsa-miR-361-5p hsa-miR-376b hsa-miR-218-1* hsa-miR-374a hsa-miR-4275
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDK19

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CDK19
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    GenScript: all cDNA clones in your preferred vector: CDK19 (NM_015076)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK19
    Addgene plasmids for CDK19 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CDK19 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton1
    cytosol1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK19 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3L1CAM interactions
    Developmental Biology0.63


    Find genes that share SuperPaths with CDK19           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CDK19
        Cell Cycle Control of Chromosomal Replication

    2 Reactome Pathways for CDK19
        Transcriptional regulation of white adipocyte differentiation
    PPARA activates gene expression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK19
    Interactions:

        Search GeneGlobe Interaction Network for CDK19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK19 (Q9BWU13 ENSP000003579074) via UniProtKB, MINT, STRING, and/or I2D (see all 211)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3FO003033, ENSP000003100404I2D: score=2 STRING: ENSP00000310040
    MED1Q156483, ENSP000003006514I2D: score=2 STRING: ENSP00000300651
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=2 
    MED28Q9H2043, ENSP000002373804I2D: score=2 STRING: ENSP00000237380
    MED29Q9NX703, ENSP000003143434I2D: score=2 STRING: ENSP00000314343
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0051301cell division ----

    Find genes that share ontologies with CDK19           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDK19

    2 HMDB Compounds for CDK19    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDK19 gene: 
    NM_015076.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368911(uc003puh.1) ENST00000323817(uc011eax.1 uc003pui.1)
    ENST00000457688 ENST00000463016 ENST00000460913 ENST00000468997 ENST00000497709
    ENST00000413605
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDK19 (see all 111):
    hsa-miR-607 hsa-miR-520f hsa-miR-520e hsa-miR-361-5p hsa-miR-376b hsa-miR-218-1* hsa-miR-374a hsa-miR-4275
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CDK19 (NM_015076)
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    Addgene plasmids for CDK19 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK19
      QuantiTect SYBR Green Assays in human, mouse, rat CDK19
      QuantiFast Probe-based Assays in human, mouse, rat CDK19

    Selected AceView cDNA sequences (see all 188):

    H90375 BQ023376 BC037289 AI085029 AI301074 AA806264 AA339816 AI472152 
    AL122055 AA910982 AI078052 CN480629 AA460757 BM975293 BE219385 NM_015076 
    AA428200 AA649134 AI123220 AA994004 AA460158 AI472163 AA043107 AI808361 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CDK19    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:        -     -     -                                                                                       
    SP2:                    -     -                                                                                 
    SP3:                                                                                                            


    ECgene alternative splicing isoforms for CDK19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTGCAGGA
    CDK19 Expression
    About this image

    CDK19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK19 Protein Expression
        Custom PCR Arrays for CDK19
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK19 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk191 , 5 cyclin-dependent kinase 191, 5 90.35(n)1
    96.61(a)1
      10 (21.94 cM)5
    783341  NM_001168304.11  NP_001161776.11 
     403493085 
    chicken
    (Gallus gallus)
    Aves CDK191 cyclin-dependent kinase 19 85.4(n)
    93.46(a)
      421756  XM_419786.4  XP_419786.4 
    lizard
    (Anolis carolinensis)
    Reptilia CDK196
    cyclin-dependent kinase 19
    95(a)
    1 ↔ 1
    1(191837089-191977741)
    African clawed frog
    (Xenopus laevis)
    Amphibia cdk-8-prov2 Cyclin-Dependent Kinase (67.8 kD) (cdk-8) 80.51(n)    BC056076.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk191 cyclin-dependent kinase 19 74.91(n)
    89.1(a)
      100149670  XM_001923318.4  XP_001923353.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk86
    Cyclin-dependent kinase 8
    72(a)
    1 → many
    3L(9830180-9831791)
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-86
    Protein CDK-8 (cdk-8) mRNA, complete cds
    44(a)
    1 → many
    I(8702478-8705796) WBGene00000409
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSN36
    Cyclin-dependent protein kinase, component of RNA ...
    29(a)
    1 → many
    XVI(473040-474707) YPL042C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CDKE;11 CDKE;1 51.98(n)
    47.25(a)
      836481  NM_125756.4  NP_201166.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g05803001 Os10g0580300 54.77(n)
    50.44(a)
      4349519  NM_001072044.1  NP_001065512.1 


    ENSEMBL Gene Tree for CDK19 (if available)
    TreeFam Gene Tree for CDK19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK19 gene
    CDK82  
    Selected SIMAP similar genes for CDK19 using alignment to 5 protein entries:     CDK19_HUMAN (see all proteins) (see all similar genes):
    DKFZp434M058    CDK8    MAPK8    STK36    STK25    CDK11B
    CDK10    CDK16    MAPK7    CDK3    CDK6    CDC2L1
    CDC2L2    DKFZp564L2416    MAK    CDKL1    CDK4    NLK

    Find genes that share paralogs with CDK19           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK19 (see all 3745)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs567108191,2
    C--108690359(+) AAAAA-/A/AAA 
     AAAAAAA
    GAAAG
    1 -- int12NA 4
    rs2019588191,2
    C--110931078(+) TTCTA-/CCTC  
      AGCCTC
    CCGAA
    1 -- ds50010--------
    rs2014302441,2
    C--110931080(+) CTACC-/TCAGCCTC 1 -- ds50010--------
    rs1999721641,2
    C--110931084(+) CTCAG-/CCTCCC
            
    GAAGT
    1 -- ds50010--------
    rs2011464661,2
    C--110931091(+) TCCCGA/GAGTGC 1 -- ds50010--------
    rs3703073631,2
    C--110931094(+) CGAAG-/TGCTGA 1 -- ds50010--------
    rs21406721,2
    C,F,A,H--110931135(+) ACTAAA/GCCTTA 1 -- ds500121Minor allele frequency- G:0.34NS EA NA WA CSA 1010
    rs1814952891,2
    --110931260(+) ATTTCA/CAGAAG 1 -- ut310--------
    rs117549351,2
    H--110931337(+) GAGCAG/AGCCTC 1 -- ut314Minor allele frequency- A:0.00NS EA 420
    rs1410838431,2
    --110931387(+) AGCACA/GAAAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CDK19 (110931181 - 111137161 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CDK19 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732571CNV Deletion23290073
    esv2672817CNV Deletion23128226
    esv2670731CNV Deletion23128226
    esv268054CNV Insertion20981092
    nsv516177CNV Loss19592680
    nsv830770CNV Loss17160897
    nsv823823CNV Loss20364138
    nsv830773CNV Loss17160897
    nsv830772CNV Gain17160897
    nsv886538CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614720    OMIM disorders: --


    Find genes that share disorders with CDK19           About GenesLikeMe

    Genetic Association Database (GAD): CDK19
    Human Genome Epidemiology (HuGE) Navigator: CDK19 (2 documents)

    Export disorders for CDK19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK19 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with CDK19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R.... Ohara O. (DNA Res. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (Nat. Cell Biol. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction. (PubMed id 23563140)1 Tsai K.L....Asturias F.J. (amp 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes. (PubMed id 23749998)1 Tsutsui T....Ohkuma Y. (J. Biol. Chem. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23097 HGNC: 19338 AceView: CDK11 Ensembl:ENSG00000155111 euGenes: HUgn23097
    ECgene: CDK19 H-InvDB: CDK19

    (According to HUGE)
    About This Section

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    HUGE: KIAA1028

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDK19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDK19 gene:
    Search GeneIP for patents involving CDK19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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