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Aliases for CDK19 Gene

Aliases for CDK19 Gene

  • Cyclin Dependent Kinase 19 2 3 5
  • Cell Division Cycle 2-Like Protein Kinase 6 3 4
  • Cell Division Cycle 2-Like 6 (CDK8-Like) 2 3
  • Cyclin-Dependent Kinase (CDC2-Like) 11 2 3
  • Cell Division Protein Kinase 19 3 4
  • CDC2-Related Protein Kinase 6 3 4
  • Cyclin-Dependent Kinase 11 3 4
  • Death-Preventing Kinase 3 4
  • CDC2L6 3 4
  • CDK11 3 4
  • Cyclin Dependent Kinase 19 Variant 2 3
  • CDK8-Like Cyclin-Dependent Kinase 3
  • Cyclin-Dependent Kinase 19 3
  • EC 2.7.11.22 4
  • BA346C16.3 3
  • EC 2.7.11 61
  • KIAA1028 4

External Ids for CDK19 Gene

Previous HGNC Symbols for CDK19 Gene

  • CDK11
  • CDC2L6

Previous GeneCards Identifiers for CDK19 Gene

  • GC06M111039
  • GC06M110932
  • GC06M108502

Summaries for CDK19 Gene

Entrez Gene Summary for CDK19 Gene

  • This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for CDK19 Gene

CDK19 (Cyclin Dependent Kinase 19) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK8.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK19 Gene

Genomics for CDK19 Gene

Regulatory Elements for CDK19 Gene

Enhancers for CDK19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F110873 1.5 FANTOM5 ENCODE 19 -60.0 -60040 6.6 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FCF1P5 MFSD4B RPF2 CDK19 ENSG00000231046 RN7SL617P ENSG00000220506 GTF3C6 RNU6-957P WASF1
GH06F110944 1.6 FANTOM5 Ensembl ENCODE 11.3 -128.4 -128403 1.4 HDGF HDAC1 TBP PKNOX1 ATF1 TBL1XR1 WRNIP1 BMI1 CBX5 SCRT2 RPF2 CDK19 AMD1 SLC16A10 GTF3C6 LOC442244
GH06F110681 1.2 Ensembl ENCODE 11.5 +134.2 134193 1.4 PKNOX1 MLX WRNIP1 SIN3A ARID4B FEZF1 YY1 REST TBX21 PPARG AMD1 CDK19 GTF3C6 RNU6-957P RPF2 RPS20P18 LOC100129155
GH06F110813 1.2 ENCODE 11 +1.2 1210 4.1 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 MFSD4B RPF2 FCF1P5 ENSG00000220506 CDK19 BRD7P4 AMD1
GH06F110866 1.1 Ensembl ENCODE 11.6 -51.0 -50973 2.6 LEF1 SAP130 ARID4B ZNF384 CEBPG RAD21 YY1 ZNF316 ELK1 HNF4G CDK19 CNN2P9 ENSG00000271607 GC06P110895
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDK19 on UCSC Golden Path with GeneCards custom track

Promoters for CDK19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001224397 1516 2801 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for CDK19 Gene

Chromosome:
6
Start:
110,609,978 bp from pter
End:
110,816,516 bp from pter
Size:
206,539 bases
Orientation:
Minus strand

Genomic View for CDK19 Gene

Genes around CDK19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK19 Gene

Proteins for CDK19 Gene

  • Protein details for CDK19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWU1-CDK19_HUMAN
    Recommended name:
    Cyclin-dependent kinase 19
    Protein Accession:
    Q9BWU1
    Secondary Accessions:
    • Q5JQZ7
    • Q5JR00
    • Q8TC78
    • Q9UPX2

    Protein attributes for CDK19 Gene

    Size:
    502 amino acids
    Molecular mass:
    56802 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH24247.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK19 Gene

Selected DME Specific Peptides for CDK19 Gene

Q9BWU1:
  • VLHRDLK
  • YRAPELLL

Post-translational modifications for CDK19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CDK19 Gene

Protein Domains for CDK19 Gene

Suggested Antigen Peptide Sequences for CDK19 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWU1

UniProtKB/Swiss-Prot:

CDK19_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK19: view

Function for CDK19 Gene

Molecular function for CDK19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for CDK19 Gene

Gene Ontology (GO) - Molecular Function for CDK19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CDK19: view
genes like me logo Genes that share phenotypes with CDK19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK19

miRNA for CDK19 Gene

miRTarBase miRNAs that target CDK19

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK19 Gene

Localization for CDK19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK19 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CDK19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CDK19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK19 Gene

Pathways & Interactions for CDK19 Gene

genes like me logo Genes that share pathways with CDK19: view

SIGNOR curated interactions for CDK19 Gene

Other effect:

Gene Ontology (GO) - Biological Process for CDK19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0043065 positive regulation of apoptotic process IEA --
GO:0050729 positive regulation of inflammatory response IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDK19: view

Drugs & Compounds for CDK19 Gene

(9) Drugs for CDK19 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
AT7519 Investigational Pharma Multi-CDK inhibitor 0
Kenpaullone Pharma Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3 0
ML167 Pharma Clk4 inhibitor,highly selective 0
Nu 6027 Pharma ATR/CDK inhibitor, potent and selective 0

(1) Additional Compounds for CDK19 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(8) ApexBio Compounds for CDK19 Gene

Compound Action Cas Number
AT7519 Multi-CDK inhibitor 844442-38-2
Kenpaullone 142273-20-9
ML167 Clk4 inhibitor,highly selective 1285702-20-6
Nu 6027 ATR/CDK inhibitor, potent and selective 220036-08-8
PHA-848125 CDK inhibitor,potent and ATP-competitive 802539-81-7
Purvalanol B CDK1/CDK2/CDK4 inhibitor 212844-54-7
R547 CDK1/2/4 inhibitor,ATP-competitive 741713-40-6
Ro 3306 An ATP-competitive, potent CDK1 inhibitor 872573-93-8
genes like me logo Genes that share compounds with CDK19: view

Transcripts for CDK19 Gene

Unigene Clusters for CDK19 Gene

Cyclin-dependent kinase 19:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK19 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2: - -
SP3:

Relevant External Links for CDK19 Gene

GeneLoc Exon Structure for
CDK19
ECgene alternative splicing isoforms for
CDK19

Expression for CDK19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK19 Gene

Protein differential expression in normal tissues from HIPED for CDK19 Gene

This gene is overexpressed in Adrenal (38.9), Peripheral blood mononuclear cells (12.2), and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK19 Gene



Protein tissue co-expression partners for CDK19 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDK19 Gene:

CDK19

SOURCE GeneReport for Unigene cluster for CDK19 Gene:

Hs.744895
genes like me logo Genes that share expression patterns with CDK19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDK19 Gene

Orthologs for CDK19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK19 34 35
  • 99.85 (n)
cow
(Bos Taurus)
Mammalia CDK19 34 35
  • 94.07 (n)
dog
(Canis familiaris)
Mammalia CDK19 34 35
  • 92.45 (n)
oppossum
(Monodelphis domestica)
Mammalia CDK19 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK19 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk19 34
  • 90.82 (n)
mouse
(Mus musculus)
Mammalia Cdk19 34 16 35
  • 90.35 (n)
chicken
(Gallus gallus)
Aves CDK19 34 35
  • 85.4 (n)
lizard
(Anolis carolinensis)
Reptilia CDK19 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk19 34
  • 81.09 (n)
African clawed frog
(Xenopus laevis)
Amphibia cdk-8-prov 34
zebrafish
(Danio rerio)
Actinopterygii cdk19 34 35
  • 74.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cdk8 35
  • 72 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdk-8 35
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSN3 35
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CDKE;1 34
  • 51.98 (n)
rice
(Oryza sativa)
Liliopsida Os10g0580300 34
  • 54.77 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.6555 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 81 (a)
OneToMany
Species where no ortholog for CDK19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDK19 Gene

ENSEMBL:
Gene Tree for CDK19 (if available)
TreeFam:
Gene Tree for CDK19 (if available)

Paralogs for CDK19 Gene

Variants for CDK19 Gene

Sequence variations from dbSNP and Humsavar for CDK19 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10080825 -- 110,742,788(+) ctctc(A/G)aatcc intron-variant
rs10447427 -- 110,795,876(+) gatca(C/T)atCTA intron-variant
rs10456871 -- 110,680,440(+) GTTTA(C/T)TAAGA intron-variant
rs10457217 -- 110,637,777(+) gagtt(C/T)gagac intron-variant
rs10457218 -- 110,640,169(+) gggta(C/T)tactg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK19 Gene

Variant ID Type Subtype PubMed ID
esv2670731 CNV deletion 23128226
esv2672817 CNV deletion 23128226
esv2732571 CNV deletion 23290073
esv3378392 CNV insertion 20981092
esv3540312 CNV deletion 23714750
esv3610364 CNV loss 21293372
esv3610365 CNV loss 21293372
nsv1032572 CNV gain 25217958
nsv516177 CNV loss 19592680
nsv823823 CNV loss 20364138
nsv830770 CNV loss 17160897
nsv830772 CNV gain 17160897
nsv965750 CNV duplication 23825009
nsv830773 CNV loss 17160897

Variation tolerance for CDK19 Gene

Residual Variation Intolerance Score: 20.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK19 Gene

Disorders for CDK19 Gene

Relevant External Links for CDK19

Genetic Association Database (GAD)
CDK19
Human Genome Epidemiology (HuGE) Navigator
CDK19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK19

No disorders were found for CDK19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK19 Gene

Publications for CDK19 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for CDK19 Gene

Sources for CDK19 Gene

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