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Aliases for CDK18 Gene

Aliases for CDK18 Gene

  • Cyclin Dependent Kinase 18 2 3 5
  • Serine/Threonine-Protein Kinase PCTAIRE-3 3 4
  • Cell Division Protein Kinase 18 3 4
  • PCTAIRE-Motif Protein Kinase 3 3 4
  • PCTAIRE Protein Kinase 3 2 3
  • EC 2.7.11.22 4 61
  • PCTAIRE3 3 4
  • PCTK3 3 4
  • Cyclin-Dependent Kinase 18 3
  • EC 2.7.11 61
  • PCTAIRE 3

External Ids for CDK18 Gene

Previous HGNC Symbols for CDK18 Gene

  • PCTK3

Previous GeneCards Identifiers for CDK18 Gene

  • GC01P203741
  • GC01P205474
  • GC01P176639

Summaries for CDK18 Gene

GeneCards Summary for CDK18 Gene

CDK18 (Cyclin Dependent Kinase 18) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK17.

UniProtKB/Swiss-Prot for CDK18 Gene

  • May play a role in signal transduction cascades in terminally differentiated cells.

Gene Wiki entry for CDK18 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK18 Gene

Genomics for CDK18 Gene

Regulatory Elements for CDK18 Gene

Enhancers for CDK18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F205540 0.3 FANTOM5 13.5 +36.5 36508 0.4 ZFHX2 PRDM10 MFSD4A CDK18 RNU2-19P RNU6-418P LOC100420878 ELK4 CNTN2 TMEM81 LOC105371700
GH01F205479 1.3 FANTOM5 Ensembl ENCODE 12.4 -23.4 -23414 3.0 HDGF PKNOX1 ARID4B DMAP1 ZNF48 ZNF121 SP5 TBX21 ETV4 GLIS1 CDK18 LEMD1 LOC284577 MIR135B KLHDC8A LEMD1-AS1 NUAK2 MFSD4A RAB29 CNTN2
GH01F205282 1.5 FANTOM5 Ensembl ENCODE 11.8 -210.7 -210727 23.3 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF263 NFYC TBX21 MEF2D SSRP1 NUAK2 TMCC2 DSTYK LOC101929459 RBBP5 CDK18 MFSD4A CNTN2 TMEM81 KLHDC8A
GH01F205477 1 Ensembl ENCODE 11.7 -26.5 -26513 1.8 PKNOX1 ZNF133 ARID4B FEZF1 SCRT2 RCOR1 SP3 REST ZNF592 RCOR2 CDK18 KLHDC8A MFSD4A PM20D1 TRK-TTT8-1
GH01F205538 1.1 Ensembl ENCODE 11.6 +33.7 33745 0.6 BCOR GATA3 ZNF362 PKNOX1 PATZ1 CEBPB MFSD4A RNU2-19P CDK18 RNU6-418P LOC100420878 ELK4 LOC105371700
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CDK18 on UCSC Golden Path with GeneCards custom track

Promoters for CDK18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001527900 444 1601 PKNOX1 ARID4B SIN3A ZNF2 SLC30A9 GLIS2 ZNF263 SP3 NFYC REST

Genomic Location for CDK18 Gene

Chromosome:
1
Start:
205,504,556 bp from pter
End:
205,532,793 bp from pter
Size:
28,238 bases
Orientation:
Plus strand

Genomic View for CDK18 Gene

Genes around CDK18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK18 Gene

Proteins for CDK18 Gene

  • Protein details for CDK18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07002-CDK18_HUMAN
    Recommended name:
    Cyclin-dependent kinase 18
    Protein Accession:
    Q07002
    Secondary Accessions:
    • Q5VXQ2
    • Q6V3A2
    • Q6V3A3
    • Q96F90

    Protein attributes for CDK18 Gene

    Size:
    472 amino acids
    Molecular mass:
    54180 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDK18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK18 Gene

Post-translational modifications for CDK18 Gene

  • Ubiquitination at Lys 144
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for CDK18

Domains & Families for CDK18 Gene

Gene Families for CDK18 Gene

Protein Domains for CDK18 Gene

Graphical View of Domain Structure for InterPro Entry

Q07002

UniProtKB/Swiss-Prot:

CDK18_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK18: view

Function for CDK18 Gene

Molecular function for CDK18 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
May play a role in signal transduction cascades in terminally differentiated cells.

Enzyme Numbers (IUBMB) for CDK18 Gene

Gene Ontology (GO) - Molecular Function for CDK18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 15161933
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK18: view
genes like me logo Genes that share phenotypes with CDK18: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK18

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK18 Gene

Localization for CDK18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK18 Gene COMPARTMENTS Subcellular localization image for CDK18 gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CDK18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with CDK18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDK18 Gene

Pathways & Interactions for CDK18 Gene

SuperPathways for CDK18 Gene

No Data Available

Pathways by source for CDK18 Gene

1 GeneTex pathway for CDK18 Gene

Gene Ontology (GO) - Biological Process for CDK18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDK18: view

No data available for SIGNOR curated interactions for CDK18 Gene

Drugs & Compounds for CDK18 Gene

(1) Drugs for CDK18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for CDK18 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK18: view

Transcripts for CDK18 Gene

Unigene Clusters for CDK18 Gene

Cyclin-dependent kinase 18:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK18 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a ·
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - -
SP8:
SP9:
SP10:
SP11: - - - - - - - - -
SP12:
SP13:
SP14: - -
SP15:
SP16: -
SP17:
SP18: - - - - - - -
SP19: - -

ExUns: 12b ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7:
SP8: - - - - -
SP9: -
SP10: - -
SP11:
SP12: - -
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for CDK18 Gene

GeneLoc Exon Structure for
CDK18
ECgene alternative splicing isoforms for
CDK18

Expression for CDK18 Gene

mRNA expression in normal human tissues for CDK18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDK18 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.6) and Brain - Substantia nigra (x6.2).

Protein differential expression in normal tissues from HIPED for CDK18 Gene

This gene is overexpressed in Spinal cord (31.7), Frontal cortex (13.7), and Retina (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK18 Gene



Protein tissue co-expression partners for CDK18 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDK18 Gene:

CDK18

SOURCE GeneReport for Unigene cluster for CDK18 Gene:

Hs.445402

mRNA Expression by UniProt/SwissProt for CDK18 Gene:

Q07002-CDK18_HUMAN
Tissue specificity: Isoform 3 expression is limited to several subcortical nuclei of the basal gangli and the spinal cord. Isoform 2 is widely expressed.
genes like me logo Genes that share expression patterns with CDK18: view

Primer Products

Orthologs for CDK18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK18 34
  • 94.87 (n)
cow
(Bos Taurus)
Mammalia PCTK3 35
  • 93 (a)
OneToOne
CDK18 34
  • 91.15 (n)
mouse
(Mus musculus)
Mammalia Cdk18 34 16 35
  • 89.06 (n)
rat
(Rattus norvegicus)
Mammalia Cdk18 34
  • 88.62 (n)
dog
(Canis familiaris)
Mammalia CDK18 34 35
  • 88.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDK18 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK18 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK18 35
  • 84 (a)
OneToOne
PCTK3 34
  • 79.42 (n)
lizard
(Anolis carolinensis)
Reptilia CDK18 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk18 34
  • 69.65 (n)
zebrafish
(Danio rerio)
Actinopterygii CDK18 35
  • 80 (a)
OneToOne
LOC100150007 34
  • 72.47 (n)
worm
(Caenorhabditis elegans)
Secernentea pct-1 35
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 35
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10414 35
  • 56 (a)
OneToMany
Species where no ortholog for CDK18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK18 Gene

ENSEMBL:
Gene Tree for CDK18 (if available)
TreeFam:
Gene Tree for CDK18 (if available)

Paralogs for CDK18 Gene

Variants for CDK18 Gene

Sequence variations from dbSNP and Humsavar for CDK18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1042827 -- 205,531,645(+) GGGGG(A/G)GCGGT nc-transcript-variant, utr-variant-3-prime
rs1042832 -- 205,532,341(+) GTGCC(A/G)GGCTG nc-transcript-variant, utr-variant-3-prime
rs10494870 -- 205,507,061(+) GCCCG(A/G)CTTGA intron-variant
rs10900498 -- 205,504,079(+) GGACA(A/C)GTTGA upstream-variant-2KB
rs10900499 -- 205,504,306(+) AGAGG(A/T)AGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDK18 Gene

Variant ID Type Subtype PubMed ID
esv2657432 CNV deletion 23128226
esv3588637 CNV loss 21293372
nsv468027 CNV loss 19166990
nsv509602 CNV insertion 20534489
nsv549043 CNV loss 21841781
nsv820091 CNV gain 19587683

Variation tolerance for CDK18 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.74; 73.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK18 Gene

Disorders for CDK18 Gene

Relevant External Links for CDK18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK18

No disorders were found for CDK18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK18 Gene

Publications for CDK18 Gene

  1. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. (PMID: 15019984) Herskovits A.Z. … Davies P. (Gene 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. (PMID: 8088790) Okuda T. … Downing J.R. (Genomics 1994) 3 22 64

Products for CDK18 Gene

Sources for CDK18 Gene

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