Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK18 Gene

protein-coding   GIFtS: 53
GCID: GC01P205474

Cyclin-Dependent Kinase 18

(Previous name: PCTAIRE protein kinase 3)
(Previous symbol: PCTK3)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 181 2     PCTAIRE32 3
PCTK31 2 3 5     PCTAIRE-Motif Protein Kinase 32 3
PCTAIRE Protein Kinase 31 2     EC 2.7.11.223 8
Cell Division Protein Kinase 182 3     PCTAIRE2
Serine/Threonine-Protein Kinase PCTAIRE-32 3     EC 2.7.118

External Ids:    HGNC: 87511   Entrez Gene: 51292   Ensembl: ENSG000001172667   OMIM: 1691905   UniProtKB: Q070023   

Export aliases for CDK18 gene to outside databases

Previous GC identifers: GC01P203741 GC01P176639


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CDK18 Gene: 
CDK18 (cyclin-dependent kinase 18) is a protein-coding gene. Diseases associated with CDK18 include anogenital venereal wart, and alzheimer's disease. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK6.

UniProtKB/Swiss-Prot: CDK18_HUMAN, Q07002
Function: May play a role in signal transduction cascades in terminally differentiated cells

Gene Wiki entry for CDK18 (PCTK3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK18
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK18 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31-q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31-q32

CDK18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK18 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P205474:  view genomic region     (about GC identifiers)

Start:
205,473,684 bp from pter      End:
205,501,921 bp from pter
Size:
28,238 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK18_HUMAN, Q07002 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 18  
Size: 472 amino acids; 54180 Da
Secondary accessions: Q5VXQ2 Q6V3A2 Q6V3A3 Q96F90
Alternative splicing: 3 isoforms:  Q07002-1   Q07002-2   Q07002-3   

Explore the universe of human proteins at neXtProt for CDK18: NX_Q07002

Explore proteomics data for CDK18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07002

  • 4/19 DME Specific Peptides for CDK18 (Q07002) (see all 19)
     DLKQYLD  LGTPTEE  ILHRDLK  VVTLWYR 

    CDK18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK18 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_002587.2  NP_997667.1  NP_997668.1  

    ENSEMBL proteins: 
     ENSP00000399082   ENSP00000422470   ENSP00000425036   ENSP00000423665   ENSP00000353176  
     ENSP00000422842   ENSP00000423408   ENSP00000397831   ENSP00000426368   ENSP00000391324  
     ENSP00000425177  

    Human Recombinant Protein Products for CDK18: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CDK18
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CDK18
    GenScript Custom Purified and Recombinant Proteins Services for CDK18
    Novus Biologicals CDK18 Proteins
    Novus Biologicals CDK18 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK18 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    CDK18 for ontologies           About GeneDecksing



    CDK18 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CDK18
    GenScript Custom Superior Antibodies Services for CDK18
    Novus Biologicals CDK18 Antibodies
    Abcam antibodies for CDK18
    Cloud-Clone Corp. Antibodies for CDK18 
    ThermoFisher Antibodies for CDK18
    LSBio Antibodies in human, mouse, rat for CDK18 

    Assay Products for CDK18: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK18
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK18 
    Cloud-Clone Corp. CLIAs for CDK18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 18 
    TAIRE subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q07002

    ProtoNet protein and cluster: Q07002

    UniProtKB/Swiss-Prot: CDK18_HUMAN, Q07002
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK18_HUMAN, Q07002
    Function: May play a role in signal transduction cascades in terminally differentiated cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity NAS--
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004871signal transducer activity NAS--
         
    CDK18 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDK18:
     Decreased focal adhesion (FA)   Decreased nuclei size in G2M  Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK18 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK18 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK18 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK18
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK18 (see all 18):
    hsa-miR-485-5p hsa-miR-3910 hsa-miR-513a-5p hsa-miR-128 hsa-miR-1271 hsa-miR-183* hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidCDK18 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDK18
    Sirion Biotech Customized adenovirus for overexpression of CDK18

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDK18 (see all 18)
    OriGene ORF clones in mouse, rat for CDK18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDK18 (NM_212502)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK18
    Sirion Biotech Customized lentivirus for stable overexpression of CDK18 
                         Customized lentivirus expression plasmids for stable overexpression of CDK18 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDK18
    Search LifeMap BioReagents cell lines for CDK18
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK18


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK18

    5/10 Interacting proteins for CDK18 (Q070022, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3MINT-3294636 MINT-3295392 I2D: score=1 
    CCDC85BQ158343I2D: score=4 
    CCNKO759093I2D: score=4 
    SEC23AQ154363I2D: score=3 
    DVL1O146403I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation NAS--
    GO:0007165signal transduction NAS--

    CDK18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK18

    2 HMDB Compounds for CDK18    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about CDK18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK18 gene (3 alternative transcripts): 
    NM_002596.3  NM_212502.2  NM_212503.2  

    Unigene Cluster for CDK18:

    Cyclin-dependent kinase 18
    Hs.445402  [show with all ESTs]
    Unigene Representative Sequence: AK126879
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000429964 ENST00000512922 ENST00000504648(uc010pri.2) ENST00000506784(uc009xbk.2 uc009xbl.2)
    ENST00000360066(uc001hcp.3 uc001hcq.3 uc001hcr.3) ENST00000507067
    ENST00000462976 ENST00000478560 ENST00000443813 ENST00000506215 ENST00000419301
    ENST00000509056(uc009xbm.1) ENST00000507240 ENST00000515494(uc010prj.2 uc001hcs.3)
    ENST00000476153 ENST00000505932 ENST00000489617 ENST00000506489

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK18
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK18 (see all 18):
    hsa-miR-485-5p hsa-miR-3910 hsa-miR-513a-5p hsa-miR-128 hsa-miR-1271 hsa-miR-183* hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidCDK18 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK18
    Clone
    Products:
         
    OriGene clones in human, mouse for CDK18 (see all 18)
    OriGene ORF clones in mouse, rat for CDK18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDK18 (NM_212502)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK18
    Sirion Biotech Customized lentivirus for stable overexpression of CDK18 
                         Customized lentivirus expression plasmids for stable overexpression of CDK18 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK18
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK18
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK18
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK18

    Additional mRNA sequence: 

    AB209307.1 AK126879.1 AK293756.1 AK295272.1 AK295654.1 AK296320.1 AK308913.1 AL161977.1 
    AY353237.1 AY353238.1 AY353239.1 AY353240.1 BC000281.2 BC009223.2 BC011526.1 BC040529.1 
    BT007299.1 X66362.1 

    20 DOTS entries:

    DT.214567  DT.102842547  DT.100785002  DT.101963875  DT.121397444  DT.101982968  DT.100785004  DT.75105381 
    DT.100784999  DT.86563427  DT.100785003  DT.95214500  DT.95082535  DT.95126887  DT.97844728  DT.100785000 
    DT.121397433  DT.121397543  DT.95188091  DT.97844731 

    24/195 AceView cDNA sequences (see all 195):

    BU557003 BQ959086 AU130437 T07927 CR601018 AW613813 CB045518 BG945916 
    NM_212502 BU528980 BX343391 BQ686142 R96331 NM_002596 AA394136 AY353237 
    BQ426109 BF724395 AI494275 BM457869 R00058 AI143268 BQ437828 AI290797 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for CDK18 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a ·
    SP1:              -     -     -                       -                       -     -                                         -     -                       -   
    SP2:              -     -     -                       -                                                                       -     -                       -   
    SP3:                    -     -                       -                       -     -                                         -     -                       -   
    SP4:                                                                          -     -                                         -     -                       -   
    SP5:                                                                                                                          -     -                       -   

    ExUns: 12b ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
    SP1:  -           -     -     -                 -     -                                             
    SP2:  -           -     -     -                 -     -                                             
    SP3:  -           -     -     -                 -     -                                             
    SP4:  -           -     -     -                 -     -                                             
    SP5:  -           -     -     -                                                                     


    ECgene alternative splicing isoforms for CDK18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK18 expression in normal human tissues (normalized intensities)      CDK18 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDK18 Expression
    About this image


    CDK18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             atrial myocardium   
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
     
     Eye (Sensory Organs)
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Spinal Cord (Nervous System)

    See CDK18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK18

    SOURCE GeneReport for Unigene cluster: Hs.445402

    UniProtKB/Swiss-Prot: CDK18_HUMAN, Q07002
    Tissue specificity: Isoform 3 expression is limited to several subcortical nuclei of the basal gangli and the
    spinal cord. Isoform 2 is widely expressed

        SABiosciences Custom PCR Arrays for CDK18
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK18
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK18
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK18
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK18 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk181 , 5 cyclin-dependent kinase 181, 5 89.06(n)1
    91.35(a)1
      1 (57.24 cM)5
    185571  NM_008795.21  NP_032821.11 
     1321135505 
    chicken
    (Gallus gallus)
    Aves PCTK31 PCTAIRE protein kinase 3 79.49(n)
    85.04(a)
      771736  XM_001234977.2  XP_001234978.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDK186
    Uncharacterized protein
    82(a)
    1 ↔ 1
    GL343228.1(249327-282841)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001500071 cyclin-dependent kinase 18-like 72.69(n)
    80.43(a)
      100150007  XM_001919300.2  XP_001919335.2 
    worm
    (Caenorhabditis elegans)
    Secernentea pct-16
    ZC123.46
    Protein ZC123.4, isoform a
    35(a)
    31(a)
    1 ↔ many
    possible ortholog
    IV(8176485-8188879)
    I(841746-846763)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO856
    Cyclin-dependent kinase, with ten cyclin partners;...
    50(a)
    1 → many
    XVI(492018-493037)


    ENSEMBL Gene Tree for CDK18 (if available)
    TreeFam Gene Tree for CDK18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK18 gene
    CDK62  CDK52  CDK152  CDK12  CDK42  CDK32  CDK142  CDK162  
    CDK22  CDK172  
    18/44 SIMAP similar genes for CDK18 using alignment to 6 protein entries:     CDK18_HUMAN (see all proteins) (see all similar genes):
    PCTK3    PCTK1    CDK5    CDK3    CDK1    CDK16
    CDC2    CDK2    CDK15    DKFZp686L20222    CDK17    CDK7
    CDK14    CDKL3    CCRK    CDK20    STK36    CDKL4

    CDK18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/742 SNPs in CDK18 are shown (see all 742)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0478034
    ----see VAR_0478032 G R mis40--------
    VAR_0478044
    ----see VAR_0478042 T M mis40--------
    VAR_0478024
    ----see VAR_0478022 G S mis40--------
    rs339773421,2
    C--205472436(+) CAGGA-/CGGTTG 2 -- us2k10--------
    rs344428741,2
    C--205476597(+) TACTG-/AAAAAA 3 -- int11Minor allele frequency- A:0.00NA 2
    rs758745081,2
    C,F--205477945(+) CCAGCC/TTGGGC 2 -- int11Minor allele frequency- T:0.50WA 2
    rs598299901,2
    C--205488466(+) TGCTG-/CTGGGTTC 2 -- cds10--------
    rs344081851,2
    C--205488467(+) GACCC-/CT    
       G
    /TGC
    TGCTG
    4 -- cds10--------
    rs113337901,2
    C--205489828(+) ATCTC-/AAAAAA 2 -- int1 trp31Minor allele frequency- A:0.00CSA 2
    rs22753461,2
    C--205497766(-) ATCCAA/G/TTCTCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for CDK18 (205473684 - 205501921 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CDK18:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657432CNV Deletion23128226
    nsv509602CNV Insertion20534489
    nsv873115CNV Loss21882294
    nsv468027CNV Loss19166990
    nsv820091CNV Gain19587683

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK18
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 169190    OMIM disorders: --

    3 diseases for CDK18:    About MalaCards
    anogenital venereal wart    alzheimer's disease    gastric cancer


    CDK18 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for CDK18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK18 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with CDK18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. (PubMed id 15019984)1, 2 Herskovits A.Z. and Davies P. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. (PubMed id 1437147)1, 3 Okuda T....Downing J.R. (1992)
    6. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2 Meyerson M.... Tsai L.-H. (1992)
    7. Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. (PubMed id 8088790)1, 9 Okuda T....Downing J.R. (1994)
    8. Loci associated with N-glycosylation of human immunogl obulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (2013)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. 14-3-3 proteins sequester a pool of soluble TRIM32 ubi quitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5129 HGNC: 8751 AceView: PCTK3 Ensembl:ENSG00000117266 euGenes: HUgn5129
    ECgene: CDK18 H-InvDB: CDK18

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK18 gene:
    Search GeneIP for patents involving CDK18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CDK18  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CDK18  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CDK18  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDK18   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CDK18   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDK18   OriGene Custom Protein Services for CDK18  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK18
     QIAGEN SeqTarget long-range PCR primers for resequencing CDK18
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK18
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK18
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK18
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK18
     GenScript Custom Purified and Recombinant Proteins Services for CDK18 GenScript cDNA clones with any tag delivered in your preferred vector for CDK18
     GenScript Custom Assay Services for CDK18 GenScript Custom Superior Antibodies Services for CDK18
     GenScript Custom overexpressing Cell Line Services for CDK18 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for CDK18
     Search Chromatin IP Primers for CDK18
     RT2 qPCR Primer Assay in human, mouse, rat CDK18
     Search GNC Networks for CDK18
     SABiosciences Custom PCR Arrays for CDK18
     Search Tocris compounds for CDK18
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CDK18 antibodies
     CDK18 proteins
     CDK18 lysates
     Antibodies for CDK18
     See all of Abcam's Antibodies, Kits and Proteins for CDK18
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CDK18
     Antibodies for CDK18
     ELISAs for CDK18
     CLIAs for CDK18
     Search LifeMap BioReagents cell lines for CDK18
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK18
     SwitchGear 3'UTR luciferase reporter plasmids for CDK18
     SwitchGear Promoter luciferase reporter plasmids for CDK18
     ThermoFisher Antibodies for CDK18
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK18
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK18
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK18
    Customized:
     lentivirus for stable overexpression of CDK18
     lentivirus expression plasmids for stable overexpression of CDK18
     adenovirus for overexpression of CDK18
     LSBio Antibodies in human, mouse, rat for CDK18
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDK18 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4