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Aliases for CDK18 Gene

Aliases for CDK18 Gene

  • Cyclin-Dependent Kinase 18 2 3
  • PCTK3 3 4 6
  • Serine/Threonine-Protein Kinase PCTAIRE-3 3 4
  • Cell Division Protein Kinase 18 3 4
  • PCTAIRE-Motif Protein Kinase 3 3 4
  • PCTAIRE Protein Kinase 3 2 3
  • EC 2.7.11.22 4 64
  • PCTAIRE3 3 4
  • EC 2.7.11 64
  • PCTAIRE 3

External Ids for CDK18 Gene

Previous Symbols for CDK18 Gene

  • PCTK3

Summaries for CDK18 Gene

GeneCards Summary for CDK18 Gene

CDK18 (Cyclin-Dependent Kinase 18) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK15.

UniProtKB/Swiss-Prot for CDK18 Gene

  • May play a role in signal transduction cascades in terminally differentiated cells

Gene Wiki entry for CDK18 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK18 Gene

Genomics for CDK18 Gene

Genomic Location for CDK18 Gene

Start:
205,504,556 bp from pter
End:
205,532,793 bp from pter
Size:
28,238 bases
Orientation:
Plus strand

Genomic View for CDK18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK18 Gene

No data available for Regulatory Elements for CDK18 Gene

Proteins for CDK18 Gene

  • Protein details for CDK18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07002-CDK18_HUMAN
    Recommended name:
    Cyclin-dependent kinase 18
    Protein Accession:
    Q07002
    Secondary Accessions:
    • Q5VXQ2
    • Q6V3A2
    • Q6V3A3
    • Q96F90

    Protein attributes for CDK18 Gene

    Size:
    472 amino acids
    Molecular mass:
    54180 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDK18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK18 Gene

Proteomics data for CDK18 Gene at MOPED

Post-translational modifications for CDK18 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys144

Domains for CDK18 Gene

Gene Families for CDK18 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

UniProtKB/Swiss-Prot:

CDK18_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q07002
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.:
    • Q07002
genes like me logo Genes that share domains with CDK18: view

Function for CDK18 Gene

Molecular function for CDK18 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: May play a role in signal transduction cascades in terminally differentiated cells

Enzyme Numbers (IUBMB) for CDK18 Gene

Gene Ontology (GO) - Molecular Function for CDK18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 15161933
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK18: view
genes like me logo Genes that share phenotypes with CDK18: view

miRNA for CDK18 Gene

miRTarBase miRNAs that target CDK18

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK18 Gene

Localization for CDK18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK18 Gene COMPARTMENTS Subcellular localization image for CDK18 gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CDK18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with CDK18: view

Pathways for CDK18 Gene

SuperPathways for CDK18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDK18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDK18: view

No data available for Pathways by source for CDK18 Gene

Compounds for CDK18 Gene

(2) HMDB Compounds for CDK18 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with CDK18: view

Transcripts for CDK18 Gene

Unigene Clusters for CDK18 Gene

Cyclin-dependent kinase 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK18 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a ·
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - -
SP8:
SP9:
SP10:
SP11: - - - - - - - - -
SP12:
SP13:
SP14: - -
SP15:
SP16: -
SP17:
SP18: - - - - - - -
SP19: - -

ExUns: 12b ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7:
SP8: - - - - -
SP9: -
SP10: - -
SP11:
SP12: - -
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for CDK18 Gene

GeneLoc Exon Structure for
CDK18
ECgene alternative splicing isoforms for
CDK18

Expression for CDK18 Gene

mRNA expression in normal human tissues for CDK18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDK18 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (10.6) and Brain - Substantia nigra (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK18 Gene

SOURCE GeneReport for Unigene cluster for CDK18 Gene Hs.445402

mRNA Expression by UniProt/SwissProt for CDK18 Gene

Q07002-CDK18_HUMAN
Tissue specificity: Isoform 3 expression is limited to several subcortical nuclei of the basal gangli and the spinal cord. Isoform 2 is widely expressed.
genes like me logo Genes that share expressions with CDK18: view

Orthologs for CDK18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK18 36
  • 94.87 (n)
  • 93.8 (a)
cow
(Bos Taurus)
Mammalia CDK18 36
  • 91.15 (n)
  • 92.57 (a)
PCTK3 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK18 36
  • 88.31 (n)
  • 90.46 (a)
CDK18 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk18 36
  • 89.06 (n)
  • 91.35 (a)
Cdk18 16
Cdk18 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK18 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK18 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk18 36
  • 88.62 (n)
  • 92.24 (a)
chicken
(Gallus gallus)
Aves CDK18 37
  • 84 (a)
OneToOne
PCTK3 36
  • 79.42 (n)
  • 85.26 (a)
lizard
(Anolis carolinensis)
Reptilia CDK18 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk18 36
  • 69.65 (n)
  • 79.04 (a)
zebrafish
(Danio rerio)
Actinopterygii CDK18 37
  • 80 (a)
OneToOne
LOC100150007 36
  • 72.47 (n)
  • 80.22 (a)
worm
(Caenorhabditis elegans)
Secernentea pct-1 37
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 37
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10414 37
  • 56 (a)
OneToMany
Species with no ortholog for CDK18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK18 Gene

ENSEMBL:
Gene Tree for CDK18 (if available)
TreeFam:
Gene Tree for CDK18 (if available)

Paralogs for CDK18 Gene

Paralogs for CDK18 Gene

genes like me logo Genes that share paralogs with CDK18: view

Variants for CDK18 Gene

Sequence variations from dbSNP and Humsavar for CDK18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8027 -- 205,532,715(+) CCTCC(A/G)CTCCT utr-variant-3-prime, nc-transcript-variant
rs14028 -- 205,532,393(+) TTCCC(A/G)GCCCT utr-variant-3-prime, nc-transcript-variant
rs1042827 -- 205,531,645(+) GGGGG(A/G)GCGGT utr-variant-3-prime, nc-transcript-variant
rs1042832 -- 205,532,341(+) GTGCC(A/G)GGCTG utr-variant-3-prime, nc-transcript-variant
rs1105822 -- 205,513,818(-) AGGGG(C/T)GGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK18 Gene

Variant ID Type Subtype PubMed ID
nsv873115 CNV Loss 21882294
nsv509602 CNV Insertion 20534489
nsv468027 CNV Loss 19166990
esv2657432 CNV Deletion 23128226
nsv820091 CNV Gain 19587683

Relevant External Links for CDK18 Gene

HapMap Linkage Disequilibrium report
CDK18

Disorders for CDK18 Gene

No disorders were found for CDK18 Gene.

No data available for UniProtKB/Swiss-Prot for CDK18 Gene

Publications for CDK18 Gene

  1. PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. (PMID: 1437147) Okuda T. … Downing J.R. (Oncogene 1992) 2 3
  2. A family of human cdc2-related protein kinases. (PMID: 1639063) Meyerson M. … Tsai L.-H. (EMBO J. 1992) 3 4
  3. Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. (PMID: 8088790) Okuda T. … Downing J.R. (Genomics 1994) 3 23
  4. Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. (PMID: 15019984) Herskovits A.Z. … Davies P. (Gene 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CDK18 Gene

  • Addgene plasmids for CDK18

Sources for CDK18 Gene

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