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CDK18 Gene

protein-coding   GIFtS: 54
GCID: GC01P205474

Cyclin-Dependent Kinase 18

(Previous name: PCTAIRE protein kinase 3)
(Previous symbol: PCTK3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 181 2     PCTAIRE32 3
PCTK31 2 3 5     PCTAIRE-Motif Protein Kinase 32 3
PCTAIRE Protein Kinase 31 2     EC 2.7.11.223 8
Cell Division Protein Kinase 182 3     PCTAIRE2
Serine/Threonine-Protein Kinase PCTAIRE-32 3     EC 2.7.118

External Ids:    HGNC: 87511   Entrez Gene: 51292   Ensembl: ENSG000001172667   OMIM: 1691905   UniProtKB: Q070023   

Export aliases for CDK18 gene to outside databases

Previous GC identifers: GC01P203741 GC01P176639


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CDK18 Gene:
CDK18 (cyclin-dependent kinase 18) is a protein-coding gene. Diseases associated with CDK18 include anogenital venereal wart, and alzheimer's disease. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK14.

UniProtKB/Swiss-Prot: CDK18_HUMAN, Q07002
Function: May play a role in signal transduction cascades in terminally differentiated cells

Gene Wiki entry for CDK18 (PCTK3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CDK18
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK18 promoter sequence
   Search Chromatin IP Primers for CDK18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31-q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31-q32

CDK18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK18 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P205474:  view genomic region     (about GC identifiers)

Start:
205,473,684 bp from pter      End:
205,501,921 bp from pter
Size:
28,238 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDK18_HUMAN, Q07002 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 18  
Size: 472 amino acids; 54180 Da
Secondary accessions: Q5VXQ2 Q6V3A2 Q6V3A3 Q96F90
Alternative splicing: 3 isoforms:  Q07002-1   Q07002-2   Q07002-3   

Explore the universe of human proteins at neXtProt for CDK18: NX_Q07002

Explore proteomics data for CDK18 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys144
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK18 (Q07002) (see all 19)
     DLKQYLD  LGTPTEE  ILHRDLK  VVTLWYR 


    See CDK18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_002587.2  NP_997667.1  NP_997668.1  

    ENSEMBL proteins: 
     ENSP00000399082   ENSP00000422470   ENSP00000425036   ENSP00000423665   ENSP00000353176  
     ENSP00000422842   ENSP00000423408   ENSP00000397831   ENSP00000426368   ENSP00000391324  
     ENSP00000425177  

    CDK18 Human Recombinant Protein Products:

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    Novus Biologicals CDK18 Proteins
    Novus Biologicals CDK18 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CDK18

    CDK18 Antibody Products:

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    CDK18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for CDK18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 18
    TAIRE subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q07002

    ProtoNet protein and cluster: Q07002

    UniProtKB/Swiss-Prot: CDK18_HUMAN, Q07002
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK18_HUMAN, Q07002
    Function: May play a role in signal transduction cascades in terminally differentiated cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004871signal transducer activity ----
         
    CDK18 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDK18:
     Decreased focal adhesion (FA)   Decreased nuclei size in G2M  Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target CDK18:
    hsa-mir-26b-5p (MIRT029346), hsa-mir-222-3p (MIRT046594), hsa-mir-335-5p (MIRT017648)

    Block miRNA regulation of human, mouse, rat CDK18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK18 (see all 18):
    hsa-miR-485-5p hsa-miR-3910 hsa-miR-513a-5p hsa-miR-128 hsa-miR-1271 hsa-miR-183* hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidCDK18 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDK18

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK18

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CDK18 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    CDK18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK18
    Interactions:

        Search GeneGlobe Interaction Network for CDK18

    Selected Interacting proteins for CDK18 (Q070021, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631041, 2, 3EBI-746238,EBI-347088 MINT-3294636 MINT-3295392 I2D: score=1 
    CCDC85BQ158343I2D: score=4 
    CCNKO759093I2D: score=4 
    SEC23AQ154363I2D: score=3 
    DVL1O146403I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction ----

    CDK18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDK18

    2 HMDB Compounds for CDK18    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDK18 gene (3 alternative transcripts): 
    NM_002596.3  NM_212502.2  NM_212503.2  

    Unigene Cluster for CDK18:

    Cyclin-dependent kinase 18
    Hs.445402  [show with all ESTs]
    Unigene Representative Sequence: AK126879
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000429964 ENST00000512922 ENST00000504648(uc010pri.2) ENST00000506784(uc009xbk.2 uc009xbl.2)
    ENST00000360066(uc001hcp.3 uc001hcq.3 uc001hcr.3) ENST00000507067
    ENST00000462976 ENST00000478560 ENST00000443813 ENST00000506215 ENST00000419301
    ENST00000509056(uc009xbm.1) ENST00000507240 ENST00000515494(uc010prj.2 uc001hcs.3)
    ENST00000476153 ENST00000505932 ENST00000489617 ENST00000506489
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDK18 (see all 18):
    hsa-miR-485-5p hsa-miR-3910 hsa-miR-513a-5p hsa-miR-128 hsa-miR-1271 hsa-miR-183* hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidCDK18 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDK18
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    OriGene ORF clones in mouse, rat for CDK18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDK18 (NM_212502)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK18
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CDK18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK18
      QuantiTect SYBR Green Assays in human, mouse, rat CDK18
      QuantiFast Probe-based Assays in human, mouse, rat CDK18

    Additional mRNA sequence: 

    AB209307.1 AK126879.1 AK293756.1 AK295272.1 AK295654.1 AK296320.1 AK308913.1 AL161977.1 
    AY353237.1 AY353238.1 AY353239.1 AY353240.1 BC000281.2 BC009223.2 BC011526.1 BC040529.1 
    BT007299.1 X66362.1 

    20 DOTS entries:

    DT.214567  DT.102842547  DT.100785002  DT.101963875  DT.121397444  DT.101982968  DT.100785004  DT.75105381 
    DT.100784999  DT.86563427  DT.100785003  DT.95214500  DT.95082535  DT.95126887  DT.97844728  DT.100785000 
    DT.121397433  DT.121397543  DT.95188091  DT.97844731 

    Selected AceView cDNA sequences (see all 195):

    BM457869 AU130437 H06887 AI290797 BF724395 BQ959086 AI494275 BQ437828 
    CA390890 AI143268 R00058 AJ711878 NM_212503 Z38344 T07927 CR601018 
    AW613813 CB045518 BG945916 NM_212502 BU528980 BX343391 BQ686142 R96331 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK18 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a ·
    SP1:              -     -     -                       -                       -     -                                         -     -                       -   
    SP2:              -     -     -                       -                                                                       -     -                       -   
    SP3:                    -     -                       -                       -     -                                         -     -                       -   
    SP4:                                                                          -     -                                         -     -                       -   
    SP5:                                                                                                                          -     -                       -   

    ExUns: 12b ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
    SP1:  -           -     -     -                 -     -                                             
    SP2:  -           -     -     -                 -     -                                             
    SP3:  -           -     -     -                 -     -                                             
    SP4:  -           -     -     -                 -     -                                             
    SP5:  -           -     -     -                                                                     


    ECgene alternative splicing isoforms for CDK18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDK18 Expression
    About this image


    CDK18 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Heart (Cardiovascular System)
     
     Spinal Cord (Nervous System)
    CDK18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445402

    UniProtKB/Swiss-Prot: CDK18_HUMAN, Q07002
    Tissue specificity: Isoform 3 expression is limited to several subcortical nuclei of the basal gangli and the
    spinal cord. Isoform 2 is widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK18 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk181 , 5 cyclin-dependent kinase 181, 5 89.06(n)1
    91.35(a)1
      1 (57.24 cM)5
    185571  NM_008795.21  NP_032821.11 
     1321135505 
    chicken
    (Gallus gallus)
    Aves PCTK31 PCTAIRE protein kinase 3 79.42(n)
    85.26(a)
      771736  XM_001234977.3  XP_001234978.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDK186
    cyclin-dependent kinase 18
    82(a)
    1 ↔ 1
    GL343228.1(249327-282841)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdk181 cyclin-dependent kinase 18 69.65(n)
    79.04(a)
      448581  NM_001006836.1  NP_001006837.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001500071 cyclin-dependent kinase 18-like 72.47(n)
    80.22(a)
      100150007  XM_001919300.3  XP_001919335.2 
    worm
    (Caenorhabditis elegans)
    Secernentea pct-16
    Protein PCT-1, isoform c (pct-1) mRNA, complete cd...
    37(a)
    1 → many
    IV(8176485-8188879) WBGene00003961
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO856
    Cyclin-dependent kinase, with ten cyclin partners;...
    50(a)
    1 → many
    XVI(492018-493037) YPL031C


    ENSEMBL Gene Tree for CDK18 (if available)
    TreeFam Gene Tree for CDK18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK18 gene
    CDK142  CDK162  CDK52  CDK172  CDK152  
    Selected SIMAP similar genes for CDK18 using alignment to 6 protein entries:     CDK18_HUMAN (see all proteins) (see all similar genes):
    PCTK3    PCTK1    CDK5    CDK3    CDK16    CDK1
    CDC2    CDK2    CDK15    DKFZp686L20222    CDK17    CDK7
    CDK14    CDKL3    CCRK    CDK20    STK36    CDKL4

    CDK18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK18 (see all 742)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339773421,2
    C--205472436(+) CAGGA-/CGGTTG 2 -- us2k10--------
    rs344428741,2
    C--205476597(+) TACTG-/AAAAAA 3 -- int11Minor allele frequency- A:0.00NA 2
    rs758745081,2
    C,F--205477945(+) CCAGCC/TTGGGC 2 -- int11Minor allele frequency- T:0.50WA 2
    rs598299901,2
    C--205488466(+) TGCTG-/CTGGGTTC 2 -- cds10--------
    rs344081851,2
    C--205488467(+) GACCC-/CT    
       G
    /TGC
    TGCTG
    4 -- cds10--------
    rs113337901,2
    C--205489828(+) ATCTC-/AAAAAA 2 -- int1 trp31Minor allele frequency- A:0.00CSA 2
    rs22753461,2
    C--205497766(-) ATCCAA/G/TTCTCC 2 -- int10--------
    rs1180020891,2
    C,F--212009914(+) TCCATG/CACCCT 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs66924331,2
    C,F,A,H--212009949(+) GTTCCC/TTCCTC 1 -- us2k1 trp37Minor allele frequency- T:0.05NS EA NA WA 630
    rs1396317561,2
    --212009955(+) TCCTCC/TCCTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK18 (205473684 - 205501921 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CDK18:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657432CNV Deletion23128226
    nsv509602CNV Insertion20534489
    nsv873115CNV Loss21882294
    nsv468027CNV Loss19166990
    nsv820091CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK18
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 169190    OMIM disorders: --

    2 diseases for CDK18:    
    About MalaCards
    anogenital venereal wart    alzheimer's disease


    CDK18 for disorders           About GeneDecksing


    Export disorders for CDK18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK18 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CDK18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (Nat. Cell Biol. 2009)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. (PubMed id 15019984)1, 2 Herskovits A.Z. and Davies P. (Gene 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. (PubMed id 1437147)1, 3 Okuda T....Downing J.R. (Oncogene 1992)
    6. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2 Meyerson M.... Tsai L.-H. (EMBO J. 1992)
    7. Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. (PubMed id 8088790)1, 9 Okuda T....Downing J.R. (Genomics 1994)
    8. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5129 HGNC: 8751 AceView: PCTK3 Ensembl:ENSG00000117266 euGenes: HUgn5129
    ECgene: CDK18 H-InvDB: CDK18

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDK18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK18 gene:
    Search GeneIP for patents involving CDK18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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