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CDK17 Gene

protein-coding   GIFtS: 57
GCID: GC12M096673

Cyclin-Dependent Kinase 17

(Previous name: PCTAIRE protein kinase 2)
(Previous symbol: PCTK2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 171 2     PCTAIRE-Motif Protein Kinase 22 3
PCTK21 2 3     EC 2.7.11.223 8
Cell Division Protein Kinase 172 3     PCTAIRE Protein Kinase 21
Serine/Threonine-Protein Kinase PCTAIRE-22 3     Protein Kinase Cdc2-Related PCTAIRE-22
PCTAIRE22 3     EC 2.7.118

External Ids:    HGNC: 87501   Entrez Gene: 51282   Ensembl: ENSG000000597587   OMIM: 6034405   UniProtKB: Q005373   

Export aliases for CDK17 gene to outside databases

Previous GC identifers: GC12M095196 GC12M093733


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK17 Gene:
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It
has similarity to a rat protein that is thought to play a role in terminally differentiated neurons.
Alternatively spliced transcript variants encoding different isoforms have been found. (provided by RefSeq, Jul
2010)

GeneCards Summary for CDK17 Gene:
CDK17 (cyclin-dependent kinase 17) is a protein-coding gene. GO annotations related to this gene include protein kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK17_HUMAN, Q00537
Function: May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone
H1 (By similarity)

Gene Wiki entry for CDK17 (PCTK2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CDK17
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK17 promoter sequence
   Search Chromatin IP Primers for CDK17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1   Ensembl cytogenetic band:  12q23.1   HGNC cytogenetic band: 12q23.1

CDK17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK17 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M096673:  view genomic region     (about GC identifiers)

Start:
96,672,039 bp from pter      End:
96,794,366 bp from pter
Size:
122,328 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDK17_HUMAN, Q00537 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 17  
Size: 523 amino acids; 59582 Da
Subunit: Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7 (By similarity)
Secondary accessions: A8K1U6 B2RCQ2 Q8NEB8
Alternative splicing: 2 isoforms:  Q00537-1   Q00537-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK17: NX_Q00537

Explore proteomics data for CDK17 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys452, Lys493
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK17 (Q00537) (see all 18)
     FKRRLSL  VVTLWYR  DFGLARA  LADFGLA 


    See CDK17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001163935.1  NP_002586.2  

    ENSEMBL proteins: 
     ENSP00000261211   ENSP00000444459   ENSP00000442926   ENSP00000450058   ENSP00000447282  
     ENSP00000447441   ENSP00000448132  

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    Novus Biologicals CDK17 Proteins
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    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for CDK17

     
    Search eBioscience for Proteins for CDK17 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 17
    TAIRE subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q00537

    ProtoNet protein and cluster: Q00537

    UniProtKB/Swiss-Prot: CDK17_HUMAN, Q00537
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDK17           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK17_HUMAN, Q00537
    Function: May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone
    H1 (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS1639063
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI15161933
         
    Find genes that share ontologies with CDK17           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDK17:
     Decreased substrate adherent c  Increased cell death in breast 

         1 MGI phenotypic allele for Cdk17 (no phenotypes)

    Find genes that share phenotypes with CDK17           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK17
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK17
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    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK17:
    hsa-mir-98-5p (MIRT027559), hsa-mir-335-5p (MIRT017391), hsa-mir-16-5p (MIRT031589), hsa-mir-193b-3p (MIRT041319), hsa-mir-103a-3p (MIRT027115)

    Block miRNA regulation of human, mouse, rat CDK17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK17 (see all 77):
    hsa-miR-140-5p hsa-miR-549 hsa-miR-193a-3p hsa-miR-199a-3p hsa-miR-15a hsa-miR-1260b hsa-miR-1244 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidCDK17 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDK17

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CDK17 (NM_002595)
    Sino Biological Human cDNA Clone for CDK17
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK17
    Addgene plasmids for CDK17 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK17


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK17
    Interactions:

        Search GeneGlobe Interaction Network for CDK17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK17 (Q005371, 2, 3 ENSP000002612114) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631041, 2, 3, ENSP000003095034EBI-624648,EBI-347088 MINT-3295415 MINT-3294474 I2D: score=2 STRING: ENSP00000309503
    YWHAGP619812, 3, ENSP000003063304MINT-50351 I2D: score=4 STRING: ENSP00000306330
    TDRD7Q8NHU63, ENSP000003474444I2D: score=4 STRING: ENSP00000347444
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS1639063

    Find genes that share ontologies with CDK17           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDK17

    2 HMDB Compounds for CDK17    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDK17 gene (2 alternative transcripts): 
    NM_001170464.2  NM_002595.4  

    Unigene Cluster for CDK17:

    Cyclin-dependent kinase 17
    Hs.506415  [show with all ESTs]
    Unigene Representative Sequence: NM_001170464
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261211(uc001tep.2 uc009ztk.3 uc010svb.2) ENST00000543119
    ENST00000542666 ENST00000548422 ENST00000550971 ENST00000549899 ENST00000551484
    ENST00000553042 ENST00000551816 ENST00000552496 ENST00000548734 ENST00000552262

    miRNA
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    Block miRNA regulation of human, mouse, rat CDK17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK17 (see all 77):
    hsa-miR-140-5p hsa-miR-549 hsa-miR-193a-3p hsa-miR-199a-3p hsa-miR-15a hsa-miR-1260b hsa-miR-1244 hsa-miR-3150b-3p
    SwitchGear 3'UTR luciferase reporter plasmidCDK17 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for CDK17 
    Primer
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    OriGene qPCR primer pairs and template standards for CDK17
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      QuantiTect SYBR Green Assays in human, mouse, rat CDK17
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    Additional mRNA sequence: 

    AF086067.1 AK290011.1 AK315214.1 BC033005.1 X66360.1 

    11 DOTS entries:

    DT.75146876  DT.95365663  DT.99940529  DT.91832898  DT.100656191  DT.121181566  DT.40210045  DT.91728948 
    DT.121181545  DT.311769  DT.121181610 

    Selected AceView cDNA sequences (see all 118):

    BG572678 BQ896593 BE327813 AI492295 BF111798 BG506553 NM_002595 AW079292 
    BQ228350 AA370537 BM770095 AI567817 BC033005 AA291069 AI091227 AI273962 
    BM788092 BP352110 AA812037 AA370536 BF064070 BU178069 X66360 N52766 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTAAAAA
    CDK17 Expression
    About this image


    CDK17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Cerebral Cortex
             Olfactory Bulb   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalon
    CDK17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506415
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK17 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk171 , 5 cyclin-dependent kinase 171, 5 90.57(n)1
    98.66(a)1
      10 (47.89 cM)5
    2374591  NM_146239.21  NP_666351.21 
     931608765 
    chicken
    (Gallus gallus)
    Aves CDK171 cyclin-dependent kinase 17 84.64(n)
    97.9(a)
      417920  XM_004937650.1  XP_004937707.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK176
    cyclin-dependent kinase 17
    97(a)
    1 ↔ 1
    5(30362700-30454720)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043763.12   -- 83.18(n)    BC043763.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.266492 Danio rerio cDNA clone IMAGE5413024, containing frame-shift more 76.44(n)    BC055158.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pct-11 pct-1 58.21(n)
    56.65(a)
      177615  NM_068971.5  NP_501372.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO856
    Cyclin-dependent kinase, with ten cyclin partners;...
    49(a)
    1 → many
    XVI(492018-493037) YPL031C


    ENSEMBL Gene Tree for CDK17 (if available)
    TreeFam Gene Tree for CDK17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK17 gene
    CDK182  CDK142  CDK162  CDK52  CDK152  
    Selected SIMAP similar genes for CDK17 using alignment to 6 protein entries:     CDK17_HUMAN (see all proteins) (see all similar genes):
    PCTK1    PCTK3    CDK5    CDK3    CDK1    CDC2
    DKFZp686L20222    CDK18    CDK15    CDK2    CDK16    CDK14
    CCRK    CDK10    CDK20    MAPK7    CDC2L1    CDC2L2

    Find genes that share paralogs with CDK17           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK17 (see all 2358)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347544331,2
    C--96618506(+) GGCGG-/AGAGGTT 2 -- int10--------
    rs2020200151,2
    --96671557(+) TTTAT-/GAGATAT 2 -- ds50010--------
    rs104314331,2
    C,A,H--96671560(+) tatgaG/Tatata 2 -- ds50016Minor allele frequency- T:0.34NA WA 246
    rs111084511,2
    --96671562(+) TGATAG/TATATA 2 -- ds50010--------
    rs347096611,2
    --96671564(+) AGATAG/TATATA 2 -- ds50010--------
    rs583920441,2
    C--96671604(+) TATAT-/AT/ATA
    TATAT
    /TG
    GTCTC
    2 -- ds50010--------
    rs108600101,2
    C,A--96671605(+) TATATA/GTCTCA 2 -- ds50013Minor allele frequency- G:0.00WA NA CSA 5
    rs107777791,2
    C,F,A,H--96671666(+) AAAGAT/CAGATT 2 -- ds500124Minor allele frequency- C:0.07NS EA NA WA CSA 2344
    rs107777801,2
    C,F,A,H--96671691(+) AATAGT/CCTTTC 2 -- ds500122Minor allele frequency- C:0.49NS EA WA NA CSA 2346
    rs1821457741,2
    --96671812(+) TTCTCA/TTACCT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for CDK17 (96672039 - 96794366 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CDK17:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676742CNV Deletion23128226
    esv269643CNV Insertion20981092
    nsv836CNV Insertion18451855
    nsv53730CNV Insertion16902084
    esv272651CNV Insertion20981092
    nsv899457CNV Gain21882294
    nsv7234OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603440    OMIM disorders: --


    Find genes that share disorders with CDK17           About GenesLikeMe

    Genetic Association Database (GAD): CDK17
    Human Genome Epidemiology (HuGE) Navigator: CDK17 (0 documents)

    Export disorders for CDK17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK17 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with CDK17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1, 4 Demirkan A....Schmitz G. (PLoS Genet. 2012)
    2. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (Nat. Cell Biol. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons. (PubMed id 9370357)1, 3 Hirose T....Okada M. (Eur. J. Biochem. 1997)
    5. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2 Meyerson M.... Tsai L.-H. (EMBO J. 1992)
    6. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    9. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    10. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (Nature 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5128 HGNC: 8750 AceView: PCTK2 Ensembl:ENSG00000059758 euGenes: HUgn5128
    ECgene: CDK17 H-InvDB: CDK17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDK17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK17 gene:
    Search GeneIP for patents involving CDK17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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