Aliases for CDK16 Gene
External Ids for CDK16 Gene
Previous HGNC Symbols for CDK16 Gene
Previous GeneCards Identifiers for CDK16 Gene
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]
GeneCards Summary for CDK16 Gene
CDK16 (Cyclin-Dependent Kinase 16) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and DNA Damage. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK15.
UniProtKB/Swiss-Prot for CDK16 Gene
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at Ser-336 (in vitro).