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Aliases for CDK16 Gene

Aliases for CDK16 Gene

  • Cyclin Dependent Kinase 16 2 3 5
  • Serine/Threonine-Protein Kinase PCTAIRE-1 3 4
  • Cell Division Protein Kinase 16 3 4
  • PCTAIRE-Motif Protein Kinase 1 3 4
  • EC 2.7.11.22 4 61
  • PCTAIRE1 3 4
  • PCTK1 3 4
  • Testis Secretory Sperm-Binding Protein Li 224n 3
  • Serine/Threonine-Protein Kinase 2
  • Cyclin-Dependent Kinase 16 3
  • PCTAIRE Protein Kinase 1 2
  • EC 2.7.11 61
  • PCTGAIRE 3
  • PCTAIRE 3

External Ids for CDK16 Gene

Previous HGNC Symbols for CDK16 Gene

  • PCTK1

Previous GeneCards Identifiers for CDK16 Gene

  • GC0XP046963
  • GC0XP047078
  • GC0XP044787
  • GC0XP047079

Summaries for CDK16 Gene

Entrez Gene Summary for CDK16 Gene

  • The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

GeneCards Summary for CDK16 Gene

CDK16 (Cyclin Dependent Kinase 16) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Signal transduction_PKA signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK17.

UniProtKB/Swiss-Prot for CDK16 Gene

  • Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at Ser-336 (in vitro).

Gene Wiki entry for CDK16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK16 Gene

Genomics for CDK16 Gene

Regulatory Elements for CDK16 Gene

Enhancers for CDK16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF047523 1.3 FANTOM5 Ensembl ENCODE 12.2 +305.8 305841 1.4 ATF1 CBX3 ARID4B ZNF2 RAD21 ZNF366 RCOR1 ZNF391 CREM KLF13 ZNF41 LINC01560 CDK16 USP11 ELK1 CFP SYN1 SPACA5 NUS1P1 ARAF
GH0XF046836 0.9 FANTOM5 ENCODE 2.7 -378.9 -378913 5.4 ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 KLF7 FOS SP3 RP2 CDK16 ZNF674 CHST7 GC0XP046897
GH0XF047321 1.3 FANTOM5 Ensembl ENCODE 1.5 +104.0 104010 1.7 YY2 HCFC1 SIX5 YY1 POLR2A SMARCA4 CREM TCF7L2 EGR2 SNORA11C LOC100419232 RGN UBA1 CDK16 ELK1 PIR34305 GC0XM047351
GH0XF047559 1 FANTOM5 ENCODE 1.3 +344.6 344570 5.4 HDGF PKNOX1 CREB3L1 SIN3A DMAP1 ZNF2 YY1 FOS SP3 NFYC LINC01560 CFP ZNF182 ZNF630 ARAF CDK16 GC0XP047571 GC0XP047572
GH0XF047216 0.4 ENCODE 0.8 +0.7 659 5.0 HDGF PKNOX1 WRNIP1 SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF207 ZNF143 LOC100113397 ZNF674-AS1 LINC01560 ZNF81 ZNF182 INE1 UXT-AS1 LOC100419232 SNORA11C ZNF674
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CDK16 on UCSC Golden Path with GeneCards custom track

Promoters for CDK16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000478257 1140 3201 HDGF PKNOX1 WRNIP1 SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF207 ZNF143

Genomic Location for CDK16 Gene

Chromosome:
X
Start:
47,217,860 bp from pter
End:
47,229,997 bp from pter
Size:
12,138 bases
Orientation:
Plus strand

Genomic View for CDK16 Gene

Genes around CDK16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK16 Gene

Proteins for CDK16 Gene

  • Protein details for CDK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00536-CDK16_HUMAN
    Recommended name:
    Cyclin-dependent kinase 16
    Protein Accession:
    Q00536
    Secondary Accessions:
    • A8K280
    • B7Z7C8
    • J3KN74
    • J3KQP7

    Protein attributes for CDK16 Gene

    Size:
    496 amino acids
    Molecular mass:
    55716 Da
    Quaternary structure:
    • Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ. Interacts with NSF. Identified in a complex with NSF, syntaxin-1, synaptotagmin, SYN1, SYP and CDK5R1 (By similarity). Interacts with BRSK2. Interacts with CCNY; this increases the CDK16 kinase activity.
    SequenceCaution:
    • Sequence=AAH01048.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15607.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK16 Gene

    Alternative splice isoforms for CDK16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK16 Gene

Selected DME Specific Peptides for CDK16 Gene

Q00536:
  • DLKQYLD
  • GELKLADFGLA
  • DFGLARA
  • FLFQLLRGL
  • LKHANIV
  • LRGLAYCH
  • IGFGKLETY
  • VVTLWYR
  • LADFGLA
  • KLGEGTYATV
  • VLHRDLK
  • GRPLFPGS
  • GRPLFPG
  • LGTPTEE
  • HRDLKPQN
  • NVKLFLFQLLRGL

Post-translational modifications for CDK16 Gene

  • Phosphorylation at Ser-153 inhibits kinase activity.
  • Ubiquitination at Lys 133, Lys 167, Lys 194, Lys 455, and Lys 466
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK16 (CDK16)
  • Cloud-Clone Corp. Antibodies for CDK16

Domains & Families for CDK16 Gene

Gene Families for CDK16 Gene

Protein Domains for CDK16 Gene

Graphical View of Domain Structure for InterPro Entry

Q00536

UniProtKB/Swiss-Prot:

CDK16_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK16: view

Function for CDK16 Gene

Molecular function for CDK16 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at Ser-336 (in vitro).

Enzyme Numbers (IUBMB) for CDK16 Gene

Gene Ontology (GO) - Molecular Function for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 22184064
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 16091426
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK16: view
genes like me logo Genes that share phenotypes with CDK16: view

Animal Models for CDK16 Gene

MGI Knock Outs for CDK16:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK16

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK16 Gene

Localization for CDK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK16 Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK16 Gene COMPARTMENTS Subcellular localization image for CDK16 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 22798068
GO:0005886 plasma membrane IDA --
GO:0008021 colocalizes_with synaptic vesicle IEA,ISS --
GO:0015630 microtubule cytoskeleton IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CDK16: view

Pathways & Interactions for CDK16 Gene

genes like me logo Genes that share pathways with CDK16: view

Pathways by source for CDK16 Gene

1 GeneTex pathway for CDK16 Gene
1 Cell Signaling Technology pathway for CDK16 Gene
1 GeneGo (Thomson Reuters) pathway for CDK16 Gene
2 Qiagen pathways for CDK16 Gene

SIGNOR curated interactions for CDK16 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006887 exocytosis IEA,ISS --
GO:0007283 spermatogenesis ISS --
GO:0016310 phosphorylation IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with CDK16: view

Drugs & Compounds for CDK16 Gene

(1) Drugs for CDK16 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME} Experimental Pharma Target 0
genes like me logo Genes that share compounds with CDK16: view

Transcripts for CDK16 Gene

Unigene Clusters for CDK16 Gene

Cyclin-dependent kinase 16:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK16 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8: - - - -
SP9: -
SP10:
SP11: - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - - - - - -
SP15: - - - -
SP16: - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - -
SP19:
SP20:
SP21: - - - - - -

ExUns: 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ·
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - - - - - - - - - - - - - - - - - - - - - - - -
SP18:
SP19:
SP20:
SP21:

Relevant External Links for CDK16 Gene

GeneLoc Exon Structure for
CDK16
ECgene alternative splicing isoforms for
CDK16

Expression for CDK16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK16 Gene

Protein differential expression in normal tissues from HIPED for CDK16 Gene

This gene is overexpressed in Plasma (20.4), Testis (15.1), Fetal Brain (12.1), and Heart (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK16 Gene



Protein tissue co-expression partners for CDK16 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDK16 Gene:

CDK16

SOURCE GeneReport for Unigene cluster for CDK16 Gene:

Hs.496068

mRNA Expression by UniProt/SwissProt for CDK16 Gene:

Q00536-CDK16_HUMAN
Tissue specificity: Detected in pancreas islets (at protein level). Detected in brain and pancreas.
genes like me logo Genes that share expression patterns with CDK16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK16 Gene

Orthologs for CDK16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK16 34 35
  • 99.76 (n)
cow
(Bos Taurus)
Mammalia PCTK1 35
  • 98 (a)
OneToOne
CDK16 34
  • 94.89 (n)
mouse
(Mus musculus)
Mammalia Cdk16 34 16 35
  • 91.87 (n)
rat
(Rattus norvegicus)
Mammalia Cdk16 34
  • 91.6 (n)
dog
(Canis familiaris)
Mammalia CDK16 34 35
  • 91.11 (n)
oppossum
(Monodelphis domestica)
Mammalia CDK16 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK16 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK16 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk16 34
  • 76.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21411 34
zebrafish
(Danio rerio)
Actinopterygii cdk16 34 35
  • 71.99 (n)
worm
(Caenorhabditis elegans)
Secernentea pct-1 35
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 35
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10414 35
  • 58 (a)
OneToMany
Species where no ortholog for CDK16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK16 Gene

ENSEMBL:
Gene Tree for CDK16 (if available)
TreeFam:
Gene Tree for CDK16 (if available)

Paralogs for CDK16 Gene

Variants for CDK16 Gene

Sequence variations from dbSNP and Humsavar for CDK16 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs727503845 Pathogenic 47,227,098(+) CACCC(C/T)GGTGA nc-transcript-variant, reference, stop-gained
rs145117961 Uncertain significance 47,225,864(+) AGTAC(C/T)TGGTA nc-transcript-variant, reference, synonymous-codon
rs17550472 Benign 47,223,273(+) TAGGG(C/T)CCTTG intron-variant, nc-transcript-variant, reference, missense
rs41305363 Benign 47,226,274(+) GGGTC(C/T)CCAGC intron-variant
rs727503843 Benign 47,223,217(+) TGGAG(C/G)CTTCT intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDK16 Gene

Variant ID Type Subtype PubMed ID
nsv1077230 CNV deletion 25765185

Variation tolerance for CDK16 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK16 Gene

Human Gene Mutation Database (HGMD)
CDK16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK16 Gene

Disorders for CDK16 Gene

Relevant External Links for CDK16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK16

No disorders were found for CDK16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK16 Gene

Publications for CDK16 Gene

  1. Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. (PMID: 22184064) Mikolcevic P. … Geley S. (Mol. Cell. Biol. 2012) 3 4 64
  2. Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase. (PMID: 22796189) Shehata S.N. … Sakamoto K. (Cell. Signal. 2012) 3 4 64
  3. Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells. (PMID: 22798068) Chen X.Y. … Yu L. (J. Biol. Chem. 2012) 3 4 64
  4. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for CDK16 Gene

Sources for CDK16 Gene

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