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Aliases for CDK16 Gene

Aliases for CDK16 Gene

  • Cyclin Dependent Kinase 16 2 3 5
  • Serine/Threonine-Protein Kinase PCTAIRE-1 3 4
  • Cell Division Protein Kinase 16 3 4
  • PCTAIRE-Motif Protein Kinase 1 3 4
  • EC 2.7.11.22 4 56
  • PCTAIRE1 3 4
  • PCTK1 3 4
  • Testis Secretory Sperm-Binding Protein Li 224n 3
  • Serine/Threonine-Protein Kinase 2
  • Cyclin-Dependent Kinase 16 3
  • PCTAIRE Protein Kinase 1 2
  • EC 2.7.11 56
  • PCTGAIRE 3
  • PCTAIRE 3

External Ids for CDK16 Gene

Previous HGNC Symbols for CDK16 Gene

  • PCTK1

Previous GeneCards Identifiers for CDK16 Gene

  • GC0XP046963
  • GC0XP047078
  • GC0XP044787
  • GC0XP047079

Summaries for CDK16 Gene

Entrez Gene Summary for CDK16 Gene

  • The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

GeneCards Summary for CDK16 Gene

CDK16 (Cyclin Dependent Kinase 16) is a Protein Coding gene. Among its related pathways are DNA Damage and Signal transduction_PKA signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK17.

UniProtKB/Swiss-Prot for CDK16 Gene

  • Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at Ser-336 (in vitro).

Gene Wiki entry for CDK16 Gene

Additional gene information for CDK16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK16 Gene

Genomics for CDK16 Gene

GeneHancer (GH) Regulatory Elements for CDK16 Gene

Promoters and enhancers for CDK16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI047216 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.7 659 5 HDGF PKNOX1 CLOCK ARNT SIN3A FEZF1 ZNF2 IRF4 YY1 POLR2B CDK16 LOC105373194 ZNF81 LOC100113397 INE1 ZNF182 ZNF674-AS1 LINC01560 USP11 ZNF674
GH0XI047223 Promoter 0.8 EPDnew 550.4 +5.2 5179 0.1 RFX1 POLR2A ZNF740 BMI1 CDK16 LOC105373194 USP11
GH0XI047523 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +305.8 305841 1 ATF1 ARID4B ZNF2 ZNF143 ATF7 RUNX3 DEK SP3 SP5 REST LINC01560 ZNF41 USP11 CDK16 ELK1 CFP SYN1 SPACA5 NUS1P1 GC0XP047511
GH0XI046836 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 2.7 -378.9 -378913 5.4 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 ZNF213 KLF7 FOS RP2 INE1 UBA1 ZNF81 ARAF CDK16 ZNF674 CHST7 GC0XP046897
GH0XI047559 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 1.3 +344.6 344569 5.4 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ZNF766 ARAF INE1 FTSJ1 ZNF81 NUS1P1 UBA1 UXT CFP CDK16 GC0XP047572
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CDK16 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CDK16 Gene

Genomic Locations for CDK16 Gene
chrX:47,217,860-47,229,997
(GRCh38/hg38)
Size:
12,138 bases
Orientation:
Plus strand
chrX:47,077,259-47,089,396
(GRCh37/hg19)

Genomic View for CDK16 Gene

Genes around CDK16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK16 Gene

Proteins for CDK16 Gene

  • Protein details for CDK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00536-CDK16_HUMAN
    Recommended name:
    Cyclin-dependent kinase 16
    Protein Accession:
    Q00536
    Secondary Accessions:
    • A8K280
    • B7Z7C8
    • J3KN74
    • J3KQP7

    Protein attributes for CDK16 Gene

    Size:
    496 amino acids
    Molecular mass:
    55716 Da
    Quaternary structure:
    • Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ. Interacts with NSF. Identified in a complex with NSF, syntaxin-1, synaptotagmin, SYN1, SYP and CDK5R1 (By similarity). Interacts with BRSK2. Interacts with CCNY; this increases the CDK16 kinase activity.
    SequenceCaution:
    • Sequence=AAH01048.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15607.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK16 Gene

    Alternative splice isoforms for CDK16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK16 Gene

Selected DME Specific Peptides for CDK16 Gene

Q00536:
  • DLKQYLD
  • GELKLADFGLA
  • DFGLARA
  • FLFQLLRGL
  • LKHANIV
  • LRGLAYCH
  • IGFGKLETY
  • VVTLWYR
  • LADFGLA
  • KLGEGTYATV
  • VLHRDLK
  • GRPLFPGS
  • GRPLFPG
  • LGTPTEE
  • HRDLKPQN
  • NVKLFLFQLLRGL

Post-translational modifications for CDK16 Gene

  • Phosphorylation at Ser-153 inhibits kinase activity.
  • Ubiquitination at posLast=133133, posLast=167167, Lys194, posLast=455455, and posLast=466466

Domains & Families for CDK16 Gene

Gene Families for CDK16 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q00536

UniProtKB/Swiss-Prot:

CDK16_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK16: view

Function for CDK16 Gene

Molecular function for CDK16 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at Ser-336 (in vitro).

Enzyme Numbers (IUBMB) for CDK16 Gene

Gene Ontology (GO) - Molecular Function for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA,IEA 22184064
GO:0004693 NOT cyclin-dependent protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 16091426
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK16: view
genes like me logo Genes that share phenotypes with CDK16: view

Animal Models for CDK16 Gene

MGI Knock Outs for CDK16:

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK16 Gene

Localization for CDK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK16 Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK16 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
nucleus 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Microtubules (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IBA --
GO:0005737 cytoplasm IEA,IDA 22798068
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA,IDA --
GO:0008021 colocalizes_with synaptic vesicle IEA,ISS --
genes like me logo Genes that share ontologies with CDK16: view

Pathways & Interactions for CDK16 Gene

genes like me logo Genes that share pathways with CDK16: view

Pathways by source for CDK16 Gene

1 GeneTex pathway for CDK16 Gene
1 Cell Signaling Technology pathway for CDK16 Gene
1 GeneGo (Thomson Reuters) pathway for CDK16 Gene
2 Qiagen pathways for CDK16 Gene

SIGNOR curated interactions for CDK16 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006887 exocytosis ISS,IEA --
GO:0007283 spermatogenesis ISS --
GO:0016310 phosphorylation IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with CDK16: view

Drugs & Compounds for CDK16 Gene

(1) Drugs for CDK16 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME} Experimental Pharma Target 0
genes like me logo Genes that share compounds with CDK16: view

Transcripts for CDK16 Gene

Unigene Clusters for CDK16 Gene

Cyclin-dependent kinase 16:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK16 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8: - - - -
SP9: -
SP10:
SP11: - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - - - - - -
SP15: - - - -
SP16: - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - -
SP19:
SP20:
SP21: - - - - - -

ExUns: 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ·
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - - - - - - - - - - - - - - - - - - - - - - - -
SP18:
SP19:
SP20:
SP21:

Relevant External Links for CDK16 Gene

GeneLoc Exon Structure for
CDK16
ECgene alternative splicing isoforms for
CDK16

Expression for CDK16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK16 Gene

Protein differential expression in normal tissues from HIPED for CDK16 Gene

This gene is overexpressed in Plasma (20.4), Testis (15.1), Fetal Brain (12.1), and Heart (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK16 Gene



Protein tissue co-expression partners for CDK16 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDK16 Gene:

CDK16

SOURCE GeneReport for Unigene cluster for CDK16 Gene:

Hs.496068

mRNA Expression by UniProt/SwissProt for CDK16 Gene:

Q00536-CDK16_HUMAN
Tissue specificity: Detected in pancreas islets (at protein level). Detected in brain and pancreas.

Evidence on tissue expression from TISSUES for CDK16 Gene

  • Nervous system(4.9)
  • Muscle(2.8)
  • Lung(2.7)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CDK16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK16 Gene

Orthologs for CDK16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK16 33 34
  • 99.76 (n)
cow
(Bos Taurus)
Mammalia PCTK1 34
  • 98 (a)
OneToOne
CDK16 33
  • 94.89 (n)
mouse
(Mus musculus)
Mammalia Cdk16 33 16 34
  • 91.87 (n)
rat
(Rattus norvegicus)
Mammalia Cdk16 33
  • 91.6 (n)
dog
(Canis familiaris)
Mammalia CDK16 33 34
  • 91.11 (n)
oppossum
(Monodelphis domestica)
Mammalia CDK16 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK16 34
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK16 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk16 33
  • 76.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21411 33
zebrafish
(Danio rerio)
Actinopterygii cdk16 33 34
  • 71.99 (n)
worm
(Caenorhabditis elegans)
Secernentea pct-1 34
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 34
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10414 34
  • 58 (a)
OneToMany
Species where no ortholog for CDK16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK16 Gene

ENSEMBL:
Gene Tree for CDK16 (if available)
TreeFam:
Gene Tree for CDK16 (if available)

Paralogs for CDK16 Gene

Variants for CDK16 Gene

Sequence variations from dbSNP and Humsavar for CDK16 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs727503845 pathogenic, not provided 47,227,098(+) C/T coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs1064795893 uncertain-significance, not specified 47,226,693(+) A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs145117961 uncertain-significance, not specified 47,225,864(+) C/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs17550472 benign, not specified 47,223,273(+) C/T coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs41305363 benign, not specified 47,226,274(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CDK16 Gene

Variant ID Type Subtype PubMed ID
nsv1077230 CNV deletion 25765185

Variation tolerance for CDK16 Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CDK16 Gene

Human Gene Mutation Database (HGMD)
CDK16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK16 Gene

Disorders for CDK16 Gene

Additional Disease Information for CDK16

No disorders were found for CDK16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK16 Gene

Publications for CDK16 Gene

  1. Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. (PMID: 22184064) Mikolcevic P … Geley S (Molecular and cellular biology 2012) 3 4 58
  2. Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase. (PMID: 22796189) Shehata SN … Sakamoto K (Cellular signalling 2012) 3 4 58
  3. Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells. (PMID: 22798068) Chen XY … Yu L (The Journal of biological chemistry 2012) 3 4 58
  4. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M … Wolgemuth DJ (Nature cell biology 2009) 2 3 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for CDK16 Gene

  • Addgene plasmids for CDK16

Sources for CDK16 Gene

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