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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK16 Gene

protein-coding   GIFtS: 58
GCID: GC0XP047078

Cyclin-Dependent Kinase 16

(Previous name: PCTAIRE protein kinase 1)
(Previous symbol: PCTK1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 161 2     EC 2.7.11.223 8
PCTK11 2 3 5     PCTAIRE Protein Kinase 11
Cell Division Protein Kinase 162 3     Serine/Threonine-Protein Kinase1
Serine/Threonine-Protein Kinase PCTAIRE-12 3     PCTAIRE2
PCTAIRE12 3     PCTGAIRE2
PCTAIRE-Motif Protein Kinase 12 3     EC 2.7.118

External Ids:    HGNC: 87491   Entrez Gene: 51272   Ensembl: ENSG000001022257   OMIM: 3115505   UniProtKB: Q005363   

Export aliases for CDK16 gene to outside databases

Previous GC identifers: GC0XP046963 GC0XP044787


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK16 Gene:
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It
may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in
transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation.
Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq,
Dec 2009)

GeneCards Summary for CDK16 Gene: 
CDK16 (cyclin-dependent kinase 16) is a protein-coding gene. Diseases associated with CDK16 include congenital stationary night blindness, and retinal disease, and among its related super-pathways are Signal transduction PKA signaling and DNA Damage. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536
Function: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1
release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal
spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the
regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at
'Ser-336' (in vitro)

Gene Wiki entry for CDK16 (PCTK1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_079573.4  NC_018934.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK16
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK16 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11

CDK16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK16 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP047078:  view genomic region     (about GC identifiers)

Start:
47,077,259 bp from pter      End:
47,089,396 bp from pter
Size:
12,138 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 16  
Size: 496 amino acids; 55716 Da
Subunit: Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ. Interacts
with NSF. Identified in a complex with NSF, syntaxin-1, synaptotagmin, SYN1, SYP and CDK5R1 (By similarity).
Interacts with BRSK2. Interacts with CCNY; this increases the CDK16 kinase activity
Subcellular location: Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane
protein; Cytoplasmic side. Cell junction, synapse, synaptosome (By similarity). Note=Colocalizes with insulin in
pancreas islets. Recruited to the cell membrane by CCNY
Sequence caution: Sequence=AAH01048.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH15607.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for CDK16:
3MTL (3D)    
Secondary accessions: A8K280 B7Z7C8 J3KN74 J3KQP7
Alternative splicing: 3 isoforms:  Q00536-1   Q00536-2   Q00536-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK16: NX_Q00536

Explore proteomics data for CDK16 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-153 inhibits kinase activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q00536

  • 4/16 DME Specific Peptides for CDK16 (Q00536) (see all 16)
     LADFGLA  DLKQYLD  LGTPTEE  LKHANIV 

    CDK16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK16 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001163931.1  NP_006192.1  NP_148978.2  

    ENSEMBL proteins: 
     ENSP00000405798   ENSP00000431085   ENSP00000430966   ENSP00000349762   ENSP00000429259  
     ENSP00000428351   ENSP00000429985   ENSP00000429044   ENSP00000429751   ENSP00000430486  
     ENSP00000428349   ENSP00000430988   ENSP00000430824   ENSP00000276052  

    Human Recombinant Protein Products for CDK16: 
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    Novus Biologicals CDK16 Proteins
    Novus Biologicals CDK16 Lysates
    Sino Biological Recombinant Protein for CDK16
    Sino Biological Cell Lysate for CDK16 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK16 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0008021colocalizes with synaptic vesicle ISS--
    GO:0030054cell junction IEA--
    GO:0030133transport vesicle IEA--
    GO:0031234extrinsic to internal side of plasma membrane IDA--

    CDK16 for ontologies           About GeneDecksing



    CDK16 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CDK16 

    Assay Products for CDK16: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CDK16
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK16 
    Cloud-Clone Corp. CLIAs for CDK16


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 16 
    TAIRE subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q00536

    ProtoNet protein and cluster: Q00536

    UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK16_HUMAN, Q00536
    Function: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1
    release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal
    spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the
    regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at
    'Ser-336' (in vitro)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA--
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16091426
         
    CDK16 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDK16:
     Decreased substrate adherent c 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cdk16):
     endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    CDK16 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdk16tm1.2Stge for CDK16

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK16 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK16 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK16 

    miRNA
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    hsa-miR-4317 hsa-miR-429 hsa-miR-1914* hsa-miR-485-3p hsa-miR-1260b hsa-miR-25 hsa-miR-889 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCDK16 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK16


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK16 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signal transduction PKA signaling
    Signal transduction PKA signaling1.00
    2DNA Damage
    Cell Cycle / Checkpoint Control0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CDK16
        Signal transduction PKA signaling


    1 Cell Signaling Technology (CST) Pathway for CDK16
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for CDK16
        Signal transduction PKA signaling




    CDK16 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/23 Interacting proteins for CDK16 (Q005361, 2, 3 ENSP000004057984) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463793I2D: score=3 
    ENSG00000096155P463793I2D: score=3 
    ENSG00000227761P463793I2D: score=3 
    ENSG00000228760P463793I2D: score=3 
    ENSG00000229524P463793I2D: score=3 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS1437147
    GO:0006887exocytosis ISS--
    GO:0007283spermatogenesis ISS--
    GO:0030252growth hormone secretion ISS--
    GO:0031175neuron projection development ISS--

    CDK16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK16

    1 DrugBank Compound for CDK16    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about CDK16

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK16 gene (3 alternative transcripts): 
    NM_001170460.1  NM_006201.4  NM_033018.3  

    Unigene Cluster for CDK16:

    Cyclin-dependent kinase 16
    Hs.496068  [show with all ESTs]
    Unigene Representative Sequence: AB209465
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000517997 ENST00000517479 ENST00000457458(uc011mli.2) ENST00000522883
    ENST00000520295 ENST00000357227(uc004dho.3 uc011mlk.2) ENST00000519758
    ENST00000520893 ENST00000517426 ENST00000522234(uc011mlj.2) ENST00000518391
    ENST00000428400 ENST00000518022 ENST00000523034 ENST00000523344 ENST00000523699
    ENST00000523543 ENST00000493213
    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK16 (see all 44):
    hsa-miR-4317 hsa-miR-429 hsa-miR-1914* hsa-miR-485-3p hsa-miR-1260b hsa-miR-25 hsa-miR-889 hsa-miR-3613-3p
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    Additional mRNA sequence: 

    AB209465.1 AK096881.1 AK290145.1 AK301832.1 AK303849.1 BC001048.2 BC006190.2 BC009852.2 
    BC015607.2 BT006827.1 X66363.1 

    24/30 DOTS entries (see all 30):

    DT.100058938  DT.100640965  DT.95110942  DT.443184  DT.100818191  DT.99983136  DT.100818193  DT.100818189 
    DT.95076636  DT.97862739  DT.121295829  DT.95263149  DT.100818182  DT.121295863  DT.91798196  DT.95208593 
    DT.100731789  DT.121295816  DT.121295817  DT.121295845  DT.121295865  DT.40220735  DT.91773109  DT.91773111 

    24/464 AceView cDNA sequences (see all 464):

    AI338323 BM972889 AL134521 BG422022 F11113 BE889809 CA433645 AI672859 
    AA232259 H02429 AI051719 BQ187876 CN481240 BU184870 BU147247 NM_033019 
    AI673573 CB153093 AA359199 AA326685 AA481247 AW514644 BQ675917 CN483617 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for CDK16 (see all 21)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a ·
    SP1:                                            -     -     -     -     -     -     -     -     -     -     -     -     -                             -         
    SP2:                                                                          -     -     -     -     -     -     -     -                             -         
    SP3:                                                                                                                                                  -         
    SP4:                                                                                                                                                  -         
    SP5:                                                                                                                                                            

    ExUns: 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ·
    SP1:                                                        -                                         -                 -     -                                 
    SP2:                                                        -                                         -                 -     -                                 
    SP3:                                                                                                  -                 -     -                                 
    SP4:                                                                                                                    -     -                                 
    SP5:                                                        -                                                           -     -                                 


    ECgene alternative splicing isoforms for CDK16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK16 expression in normal human tissues (normalized intensities)      CDK16 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACAGCCAC
    CDK16 Expression
    About this image


    CDK16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             vastus lateralis   
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow

    See CDK16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK16

    SOURCE GeneReport for Unigene cluster: Hs.496068

    UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536
    Tissue specificity: Detected in pancreas islets (at protein level). Detected in brain and pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK16 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk161 , 5 cyclin-dependent kinase 161, 5 91.87(n)1
    97.58(a)1
      X (16.18 cM)5
    185551  NM_011049.41  NP_035179.11 
     206879545 
    lizard
    (Anolis carolinensis)
    Reptilia CDK166
    cyclin-dependent kinase 16
    81(a)
    1 ↔ 1
    2(68597280-68622765)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.214112 Xenopus laevis transcribed sequence with strong similarity more 79.61(n)    BU900712.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk161 cyclin-dependent kinase 16 71.42(n)
    80.58(a)
      559750  XM_001335539.3  XP_001335575.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pct-16
    ZC123.46
    Protein ZC123.4, isoform a
    39(a)
    32(a)
    1 ↔ many
    possible ortholog
    IV(8176485-8188879)
    I(841746-846763)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO856
    Cyclin-dependent kinase, with ten cyclin partners;...
    51(a)
    1 → many
    XVI(492018-493037)


    ENSEMBL Gene Tree for CDK16 (if available)
    TreeFam Gene Tree for CDK16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK16 gene
    CDK182  CDK62  CDK52  CDK152  CDK12  CDK42  CDK32  CDK142  
    CDK22  CDK172  
    18/61 SIMAP similar genes for CDK16 using alignment to 11 protein entries:     CDK16_HUMAN (see all proteins) (see all similar genes):
    PCTK1    PCTK3    CDK5    CDK1    CDK18    CDK3
    CDC2    CDK15    CDK14    DKFZp686L20222    CDKL4    CDK17
    CDK2    CDK7    CCRK    DYRK4    CDK10    CDKL1

    CDK16 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CDK16
    PGOHUM00000257266


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/213 SNPs in CDK16 are shown (see all 213)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs70564071,2
    C,F,H--46995929(+) gagtcA/Ggggga 2 -- us2k1 tfbs3 trp37Minor allele frequency- G:0.10NS EA WA CSA 422
    rs1815159681,2
    --46996112(+) GAAGAC/GGCGGG 2 -- us2k10--------
    rs128405491,2
    C--46996508(+) TCTAAA/GGATCC 2 -- us2k10--------
    rs1864611461,2
    --46996961(+) CGAAAA/CGTCAT 2 -- ut51 us2k10--------
    rs1438607021,2
    --46996968(+) TCATCA/TTCTCG 2 -- ut51 us2k10--------
    rs1883856511,2
    --46997305(+) TGCAGC/TCCGAG 3 P S mis1 us2k10--------
    rs1808482761,2
    --46997666(+) GAAGGA/TGGTCG 2 -- int1 ut510--------
    rs1850617591,2
    --46997792(+) CTCCTC/TCAGAA 2 -- int10--------
    rs1910418611,2
    C--46997872(+) CCAGAA/GTGCAC 2 -- int10--------
    rs1838006671,2
    --46998047(+) TGCTGA/TTGGGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for CDK16 (47077259 - 47089396 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CDK16: --

    Locus Specific Mutation Databases (LSDB): CDK16
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 311550    OMIM disorders: --

    7 diseases for CDK16:    About MalaCards
    congenital stationary night blindness    retinal disease    night blindness    blindness
    retinitis    pancreatitis    neuronitis


    CDK16 for disorders           About GeneDecksing


    Export disorders for CDK16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK16 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with CDK16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells. (PubMed id 22798068)1, 2 Chen X.Y.... Yu L. (2012)
    2. Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activat ed by cyclin Y and is essential for spermatogenesis. (PubMed id 22184064)1, 2 Mikolcevic P....Geley S. (2012)
    3. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. (PubMed id 1437147)1, 3 Okuda T....Downing J.R. (1992)
    9. A family of human cdc2-related protein kinases. (PubMed id 1639063)1, 2 Meyerson M.... Tsai L.-H. (1992)
    10. Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. (PubMed id 12154078)1, 9 Graeser R....Hunt T. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5127 HGNC: 8749 AceView: PCTK1 Ensembl:ENSG00000102225 euGenes: HUgn5127
    ECgene: CDK16 H-InvDB: CDK16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK16 gene:
    Search GeneIP for patents involving CDK16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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