Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDK16 Gene

protein-coding GIFtS: 57
GCID: GC0XP047078

cyclin-dependent kinase 16

(Previous name: PCTAIRE protein kinase 1 )
(Previous symbol: PCTK1)

Explore 7 diseases affiliated with
CDK16 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 16¹ ²		Serine/Threonine-Protein Kinase PCTAIRE-1² ³
PCTK1¹ ² ³ ⁵		PCTAIRE-Motif Protein Kinase 1² ³
PCTAIRE1¹ ² ³		EC 2.7.11.22³ ⁸
PCTAIRE¹ ²		FLJ16665¹
PCTGAIRE¹ ²		PCTAIRE Protein Kinase 1¹
Cell Division Protein Kinase 16² ³		EC 2.7.11⁸

External Ids:	HGNC: 8749¹	Entrez Gene: 5127²	Ensembl: ENSG00000102225⁷	OMIM: 311550⁵	UniProtKB: Q00536³

Export aliases for CDK16 gene to outside databases

Previous GC identifers: GC0XP046963 GC0XP044787

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK16:

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may

play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of

secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing

results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Dec 2009)

UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536

Function: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1

release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal

spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the

regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336'

(in vitro)

Gene Wiki entry for CDK16 (PCTK1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_079573.4

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for CDK16
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDK16 promoter sequence

Search SABiosciences Chromatin IP Primers for CDK16

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK16

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11

CDK16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK16 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP047078: view genomic region (about GC identifiers)

Start:	47,077,259 bp from pter	End:	47,089,396 bp from pter
Size:	12,138 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536 (See protein sequence)

Recommended Name: Cyclin-dependent kinase 16

Size: 496 amino acids; 55716 Da

Subunit: Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ. Interacts with

NSF. Identified in a complex with NSF, syntaxin-1, synaptotagmin, SYN1, SYP and CDK5R1 (By similarity). Interacts with

BRSK2. Interacts with CCNY; this increases the CDK16 kinase activity

Subcellular location: Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein;

Cytoplasmic side. Cell junction, synapse, synaptosome (By similarity). Note=Colocalizes with insulin in pancreas

islets. Recruited to the cell membrane by CCNY

1 PDB 3D structure from and Proteopedia for CDK16:

3MTL (3D)

Secondary accessions: A8K280 B7Z7C8 J3KN74

Alternative splicing: 2 isoforms: Q00536-1 Q00536-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK16: NX_Q00536

Post-translational modifications:

Phosphorylation at Ser-153 inhibits kinase activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q00536

4/16 DME Specific Peptides for CDK16 (Q00536) (see all 16)

LADFGLA

DLKQYLD

LGTPTEE

LKHANIV

CDK16 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001163931.1 NP_006192.1 NP_148978.2

ENSEMBL proteins:

ENSP00000405798 ENSP00000431085 ENSP00000430966 ENSP00000349762 ENSP00000429259

ENSP00000428351 ENSP00000429985 ENSP00000429044 ENSP00000429751 ENSP00000430486

ENSP00000428349 ENSP00000430988 ENSP00000430824 ENSP00000276052

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): CDK16 OriGene Protein Over-expression Lysate (see all 3): CDK16 OriGene Custom Protein Services for CDK16
	GenScript Custom Purified and Recombinant Proteins Services for CDK16
	Novus Biologicals CDK16 Proteins Novus Biologicals CDK16 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDK16

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0008021	colocalizes with synaptic vesicle	ISS	--
GO:0030054	cell junction	IEA	--
GO:0030133	transport vesicle	IEA	--
GO:0031234	extrinsic to internal side of plasma membrane	IDA	--

CDK16 for ontologies About GeneDecksing

CDK16 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK16
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CDK16
	Browse OriGene Antibodies OriGene Custom Antibody Services for CDK16
	GenScript Custom Superior Antibodies Services for CDK16
	Novus Biologicals CDK16 Antibodies
	Search for Antibodies for CDK16 at Abcam
	Uscn Antibodies for CDK16
	ThermoFisher Antibodies for CDK16

Assay Products for CDK16:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CDK16
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDK16

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDK16 for domains About GeneDecksing

5 InterPro domains/families:

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q00536

ProtoNet protein and cluster: Q00536

UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536

Function: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1

release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal

spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the

regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336'

(in vitro)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB): EC 2.7.11.22¹ ² EC 2.7.11²

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CDK16 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK16
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK16 (see all 44):
		hsa-miR-4317 hsa-miR-429 hsa-miR-1914* hsa-miR-485-3p hsa-miR-1260b hsa-miR-25 hsa-miR-889 hsa-miR-3613-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CDK16 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK16 (see all 4) OriGene shRNA RFP: CDK16 OriGene siRNA: CDK16
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK16

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CDK16

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK16 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK16 (see all 6) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CDK16 (NM_006201)
		Sino Biological Human cDNA Clone for CDK16
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK16
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK16

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDK16
		Search LifeMap BioReagents cell lines for CDK16

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK16

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	IDA	--
GO:0004693	cyclin-dependent protein kinase activity	IEA	--
GO:0005515	protein binding	IPI	16091426
GO:0005524	ATP binding	IEA	--

CDK16 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CDK16:

Decreased substrate adherent c

Animal Models:
Mouse knock-out Cdk16^tm1.2Stge for CDK16
3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cdk16):

endocrine/exocrine gland

no phenotypic analysis

reproductive system

CDK16 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G Protein Signaling Pathways

Signal transduction_PKA signaling

0.23

Signal transduction PKA signaling

0.23

Cell Cycle / Checkpoint Control

Cell Cycle / Checkpoint Control

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CDK16

Signal transduction PKA signaling

1 Cell Signaling Technology (CST) Pathway for CDK16

Cell Cycle / Checkpoint Control

1 GeneGo (Thomson Reuters) Pathway for CDK16

Signal transduction PKA signaling

CDK16 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CDK16

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/17 Interacting proteins for CDK16 (Q00536^{1, 2, 3} ENSP00000405798⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-8006109 I2D: score=3 STRING: ENSP00000309503
SEC23A	Q15436¹^,³, ENSP00000306881⁴	EBI-726261,EBI-81088 I2D: score=3 STRING: ENSP00000306881
CDK5R1	Q15078³, ENSP00000318486⁴	I2D: score=4 STRING: ENSP00000318486
CDK5	Q00535³, ENSP00000297518⁴	I2D: score=3 STRING: ENSP00000297518
YWHAG	P61981³, ENSP00000306330⁴	I2D: score=3 STRING: ENSP00000306330

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	TAS	1437147
GO:0006887	exocytosis	ISS	--
GO:0007283	spermatogenesis	ISS	--
GO:0030252	growth hormone secretion	ISS	--
GO:0031175	neuron projection development	ISS	--

CDK16 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDK16

1 DrugBank Compound for CDK16 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about CDK16

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDK16 gene (3 alternative transcripts):

NM_001170460.1 NM_006201.4 NM_033018.3

Unigene Cluster for CDK16:

Cyclin-dependent kinase 16

Hs.496068 [show with all ESTs]

Unigene Representative Sequence: AB209465

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000517997 ENST00000517479 ENST00000457458(uc011mli.2) ENST00000522883

ENST00000520295 ENST00000357227(uc004dho.3 uc011mlk.2) ENST00000519758

ENST00000520893 ENST00000517426 ENST00000522234(uc011mlj.2) ENST00000518391

ENST00000428400 ENST00000518022 ENST00000523034 ENST00000523344 ENST00000523699

ENST00000523543 ENST00000493213

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CDK16 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK16
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK16 (see all 44):
		hsa-miR-4317 hsa-miR-429 hsa-miR-1914* hsa-miR-485-3p hsa-miR-1260b hsa-miR-25 hsa-miR-889 hsa-miR-3613-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CDK16 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK16 (see all 4) OriGene shRNA RFP: CDK16 OriGene siRNA: CDK16
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK16

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK16 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK16 (see all 6) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CDK16 (NM_006201)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK16
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK16

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK16 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CDK16
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK16
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK16

Additional cDNA sequence:

AB209465.1 AK096881.1 AK290145.1 AK301832.1 AK303849.1 BC001048.2 BC006190.2 BC009852.2

BC015607.2 BT006827.1 X66363.1

24/30 DOTS entries (see all 30):

DT.100058938 DT.100640965 DT.95110942 DT.443184 DT.100818191 DT.99983136 DT.100818193 DT.100818189

DT.95076636 DT.97862739 DT.121295829 DT.95263149 DT.100818182 DT.121295863 DT.91798196 DT.95208593

DT.100731789 DT.121295816 DT.121295817 DT.121295845 DT.121295865 DT.40220735 DT.91773109 DT.91773111

24/464 AceView cDNA sequences (see all 464):

AI144457 CB306800 H14264 F17521 BI964065 AA135519 BG178354 BM128693

CA748685 CB851841 BI223253 CK903784 AI333363 BM742270 BQ684431 AI352426

BM264559 BQ889854 R43865 NM_006201 BM973729 BQ675322 CD370257 BU508013

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for CDK16 (see all 21) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	·	4d	·	4e	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8	^	9a	·
SP1:															-		-		-		-		-		-		-		-		-		-		-		-		-										-
SP2:																									-		-		-		-		-		-		-		-										-
SP3:																																																	-
SP4:																																																	-
SP5:

ExUns:	9b	^	10	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17a	·	17b	^	18a	·	18b	^	19a	·	19b	^	20a	·	20b	^	21a	·	21b	^	22a	·	22b	^	23a	·	23b	·
SP1:																			-														-						-		-
SP2:																			-														-						-		-
SP3:																																	-						-		-
SP4:																																							-		-
SP5:																			-																				-		-

ECgene alternative splicing isoforms for CDK16

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDK16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACAGCCAC

About this image
See CDK16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDK16

SOURCE GeneReport for Unigene cluster: Hs.496068

UniProtKB/Swiss-Prot: CDK16_HUMAN, Q00536

Tissue specificity: Detected in pancreas islets (at protein level). Detected in brain and pancreas

SABiosciences Custom PCR Arrays for CDK16

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK16 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CDK16
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK16
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK16

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK16

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK16 gene from 6/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CDK16⁶	--	87(a)	1 ↔ 1	2(68598444-68622743)
African clawed frog (Xenopus laevis)	Amphibia	Xl.21411²	Xenopus laevis transcribed sequence with strong similarity more	79.61(n)		BU900712.1
zebrafish (Danio rerio)	Actinopterygii	cdk16¹	cyclin-dependent kinase 16	71.42(n) 80.58(a)		559750 XM_001335539.3 XP_001335575.1
worm (Caenorhabditis elegans)	Secernentea	cdk-2⁶ pct-1⁶	Cyclin-Dependent Kinase family member (cdk-2) PCTAIRE class cell cycle kinase family member (pct...	38(a) 37(a)	possible ortholog 1 ↔ many	I(3408035-3415072) IV(8176471-8188865)
thale cress (Arabidopsis thaliana)	eudicotyledons	CDKA1⁶ CDKB1;1⁶ (see all 5)	cyclin-dependent kinase B1-1 (see all 5)	54(a) 48(a) (see all 5)	1 ↔ many possible ortholog (see all 5)	3(18071536-18074641) 3(20059796-20061438)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	cyclin-dependent kinase A-1, putative, expressed (see all 5)	49(a) 48(a) (see all 5)	possible ortholog many ↔ many (see all 5)	1(38980259-38983035) 3(996598-1000241)

ENSEMBL Gene Tree for CDK16 (if available)
TreeFam Gene Tree for CDK16 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDK16 gene

CDK6² CDK18² CDK5² CDK15² CDK4² CDK1² CDK3² CDK14²

CDK2² CDK17²

18/63 SIMAP similar genes for CDK16 using alignment to 12 protein entries: CDK16_HUMAN (see all proteins) (see all similar genes):

PCTK1 PCTK3 CDK5 CDK18 CDK1 CDK3

CDC2 CDK15 CDK14 DKFZp686L20222 CDK17 CDK2

CDK7 CCRK CDK10 DYRK4 CDKL4 CDKL1

CDK16 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CDK16
PGOHUM00000257266

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141751126^1,2		--	47075640(+)	`TCTTCC/TCCACT`	1	--	us2k¹		0	--	--	--	--
rs188138284^1,2		--	47075737(+)	`CCATTA/GTTGCT`	1	--	us2k¹		0	--	--	--	--
rs73630265^1,2	C,	--	47075816(+)	`ACAACC/TGTTGT`	1	--	us2k¹		1		WA	2
rs191499413^1,2		--	47075935(+)	`CCTTGA/GCACCT`	1	--	us2k¹		0	--	--	--	--
rs55938641^1,2	C,	--	47076053(+)	`TACCA-/GTC TACCATTGTT`	1	--	us2k¹		0	--	--	--	--
rs183649419^1,2		--	47076096(+)	`AGATCA/GGGGCT`	2	--	us2k¹		0	--	--	--	--
rs189486803^1,2		--	47076110(+)	`CAGGCA/GGGGGT`	2	--	us2k¹		0	--	--	--	--
rs192514388^1,2		--	47076165(+)	`TAGGGG/TGGGAC`	2	--	us2k¹		0	--	--	--	--
rs139400183^1,2		--	47076256(+)	`CATTCA/GACAAA`	2	--	us2k¹		0	--	--	--	--
rs185455698^1,2		--	47076350(+)	`TTTTAC/TGTTCT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDK16 (47077259 - 47089396 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CDK16
5 Indels: 96636 83489 83487 96635 83488
Locus Specific Mutation Databases (LSDB): CDK16

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK16

DNA2.0 Custom Variant and Variant Library Synthesis for CDK16

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDK16 for disorders           About GeneDecksing

OMIM gene information: 311550    OMIM disorders: --

7 diseases for CDK16:    About MalaCards

x inactivation congenital stationary night blindness night blindness retinal disease

retinitis blindness malaria

Export disorders for CDK16 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDK16 gene, integrated from 9 sources (see all 45):
(articles sorted by number of sources associating them with CDK16)

Utopia: connect your pdf to the dynamic
world of online information

Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells. (PubMed id 22798068)^{1, 2} Chen X.Y.... Yu L. (2012)
Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activat ed by cyclin Y and is essential for spermatogenesis. (PubMed id 22184064)^{1, 2} Mikolcevic P....Geley S. (2012)
Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)^{1, 3} Malumbres M....Wolgemuth D.J. (2009)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. (PubMed id 1437147)^{1, 3} Okuda T....Downing J.R. (1992)
A family of human cdc2-related protein kinases. (PubMed id 1639063)^{1, 2} Meyerson M.... Tsai L.-H. (1992)
Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. (PubMed id 12154078)^{1, 9} Graeser R....Hunt T. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5127	HGNC: 8749	AceView: PCTK1	Ensembl:ENSG00000102225	euGenes: HUgn5127
ECgene: CDK16	H-InvDB: CDK16

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDK16	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CDK16 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CDK16 gene:
Search GeneIP for patents involving CDK16

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK16
	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CDK16
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK16		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK16
	OriGene Protein Over-expression Lysate for CDK16		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CDK16		OriGene 3'-UTR Clone for CDK16
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK16		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK16
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CDK16		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CDK16		OriGene Custom Protein Services for CDK16
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK16
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK16
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK16
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK16
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK16
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK16

	GenScript Custom Purified and Recombinant Proteins Services for CDK16		GenScript cDNA clones with any tag delivered in your preferred vector for CDK16
	GenScript Custom Assay Services for CDK16		GenScript Custom Superior Antibodies Services for CDK16
	GenScript Custom overexpressing Cell Line Services for CDK16		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for CDK16

	Search Regulatory tfbs for CDK16
	Search Chromatin IP Primers for CDK16
	RT² qPCR Primer Assay in human, mouse, rat CDK16
	Search GNC Networks for CDK16
	SABiosciences Custom PCR Arrays for CDK16

Search Tocris compounds for CDK16

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for CDK16
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CDK16 antibodies
	CDK16 proteins
	CDK16 lysates

	Search for Antibodies for CDK16 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CDK16
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CDK16 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CDK16

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK16

	SwitchGear 3'UTR luciferase reporter plasmids for CDK16
	SwitchGear Promoter luciferase reporter plasmids for CDK16

ThermoFisher Antibodies for CDK16

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK16

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CDK16 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CDK16 Gene

cyclin-dependent kinase 16

Aliases
for CDK16 gene

Summaries
for CDK16 gene

Genomic Views
for CDK16 gene

Proteins
for CDK16 gene

Protein Domains /
Families
for CDK16 gene

Function
for CDK16 gene

Pathways & Interactions
for CDK16 gene

Drugs & Compounds
for CDK16 gene

Transcripts
for CDK16 gene

Expression
for CDK16 gene

Orthologs
for CDK16 gene

Paralogs
for CDK16 gene

Genomic Variants
for CDK16 gene

Disorders / Diseases
for CDK16 gene

Publications
for CDK16 gene

External Searches for CDK16 gene

Genome Databases showing CDK16 gene

Other Databases showing CDK16 gene

Specialized Databases showing CDK16 gene

Intellectual Property
for CDK16 gene

Products
for CDK16 gene

View Random Gene

Advanced Search

Export list of displayed genes

CDK16 Gene

cyclin-dependent kinase 16

Aliasesfor CDK16 gene

Summariesfor CDK16 gene

Genomic Viewsfor CDK16 gene

Proteinsfor CDK16 gene

Protein Domains /Familiesfor CDK16 gene

Functionfor CDK16 gene

Pathways & Interactionsfor CDK16 gene

Drugs & Compoundsfor CDK16 gene

Transcriptsfor CDK16 gene

Expression for CDK16 gene

Orthologsfor CDK16 gene

Paralogsfor CDK16 gene

Genomic Variantsfor CDK16 gene

Disorders / Diseasesfor CDK16 gene

Publicationsfor CDK16 gene

External Searches for CDK16 gene

Genome Databases showing CDK16 gene

Other Databases showing CDK16 gene

Specialized Databases showing CDK16 gene

Intellectual Propertyfor CDK16 gene

Productsfor CDK16 gene

View Random Gene

Aliases
for CDK16 gene

Summaries
for CDK16 gene

Genomic Views
for CDK16 gene

Proteins
for CDK16 gene

Protein Domains /
Families
for CDK16 gene

Function
for CDK16 gene

Pathways & Interactions
for CDK16 gene

Drugs & Compounds
for CDK16 gene

Transcripts
for CDK16 gene

Expression
for CDK16 gene

Orthologs
for CDK16 gene

Paralogs
for CDK16 gene

Genomic Variants
for CDK16 gene

Disorders / Diseases
for CDK16 gene

Publications
for CDK16 gene

Intellectual Property
for CDK16 gene

Products
for CDK16 gene