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Aliases for CDK16 Gene

Aliases for CDK16 Gene

  • Cyclin-Dependent Kinase 16 2 3
  • Serine/Threonine-Protein Kinase PCTAIRE-1 3 4
  • Cell Division Protein Kinase 16 3 4
  • PCTAIRE-Motif Protein Kinase 1 3 4
  • EC 2.7.11.22 4 63
  • PCTAIRE1 3 4
  • PCTK1 3 4
  • Serine/Threonine-Protein Kinase 2
  • PCTAIRE Protein Kinase 1 2
  • EC 2.7.11 63
  • PCTGAIRE 3
  • PCTAIRE 3

External Ids for CDK16 Gene

Previous HGNC Symbols for CDK16 Gene

  • PCTK1

Previous GeneCards Identifiers for CDK16 Gene

  • GC0XP046963
  • GC0XP047078
  • GC0XP044787
  • GC0XP047079

Summaries for CDK16 Gene

Entrez Gene Summary for CDK16 Gene

  • The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

GeneCards Summary for CDK16 Gene

CDK16 (Cyclin-Dependent Kinase 16) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and DNA Damage. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK15.

UniProtKB/Swiss-Prot for CDK16 Gene

  • Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at Ser-336 (in vitro).

Gene Wiki entry for CDK16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK16 Gene

Genomics for CDK16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDK16 Gene

Chromosome:
X
Start:
47,217,860 bp from pter
End:
47,229,997 bp from pter
Size:
12,138 bases
Orientation:
Plus strand

Genomic View for CDK16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK16 Gene

No data available for Regulatory Elements for CDK16 Gene

Proteins for CDK16 Gene

  • Protein details for CDK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00536-CDK16_HUMAN
    Recommended name:
    Cyclin-dependent kinase 16
    Protein Accession:
    Q00536
    Secondary Accessions:
    • A8K280
    • B7Z7C8
    • J3KN74
    • J3KQP7

    Protein attributes for CDK16 Gene

    Size:
    496 amino acids
    Molecular mass:
    55716 Da
    Quaternary structure:
    • Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ. Interacts with NSF. Identified in a complex with NSF, syntaxin-1, synaptotagmin, SYN1, SYP and CDK5R1 (By similarity). Interacts with BRSK2. Interacts with CCNY; this increases the CDK16 kinase activity.
    SequenceCaution:
    • Sequence=AAH01048.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15607.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK16 Gene

    Alternative splice isoforms for CDK16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK16 Gene

Proteomics data for CDK16 Gene at MOPED

Post-translational modifications for CDK16 Gene

  • Phosphorylation at Ser-153 inhibits kinase activity.
  • Ubiquitination at Lys 133, Lys 167, Lys 194, Lys 455, and Lys 466
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK16 (CDK16)

Domains & Families for CDK16 Gene

Gene Families for CDK16 Gene

Graphical View of Domain Structure for InterPro Entry

Q00536

UniProtKB/Swiss-Prot:

CDK16_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK16: view

Function for CDK16 Gene

Molecular function for CDK16 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at Ser-336 (in vitro).

Enzyme Numbers (IUBMB) for CDK16 Gene

Gene Ontology (GO) - Molecular Function for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 22184064
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 16091426
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK16: view
genes like me logo Genes that share phenotypes with CDK16: view

Animal Models for CDK16 Gene

MGI Knock Outs for CDK16:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK16

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CDK16 Gene

Localization for CDK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK16 Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK16 Gene COMPARTMENTS Subcellular localization image for CDK16 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22798068
GO:0005886 plasma membrane IDA --
GO:0008021 colocalizes_with synaptic vesicle ISS --
GO:0015630 microtubule cytoskeleton IDA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CDK16: view

Pathways & Interactions for CDK16 Gene

genes like me logo Genes that share pathways with CDK16: view

Pathways by source for CDK16 Gene

2 Qiagen pathways for CDK16 Gene
1 Cell Signaling Technology pathway for CDK16 Gene
1 GeneGo (Thomson Reuters) pathway for CDK16 Gene

SIGNOR curated interactions for CDK16 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006887 exocytosis ISS --
GO:0007283 spermatogenesis ISS --
GO:0030252 growth hormone secretion ISS --
GO:0031175 neuron projection development ISS --
genes like me logo Genes that share ontologies with CDK16: view

Drugs & Compounds for CDK16 Gene

(1) Drugs for CDK16 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME} Experimental Pharma Target 0
genes like me logo Genes that share compounds with CDK16: view

Transcripts for CDK16 Gene

Unigene Clusters for CDK16 Gene

Cyclin-dependent kinase 16:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK16 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8: - - - -
SP9: -
SP10:
SP11: - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - - - - - -
SP15: - - - -
SP16: - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - -
SP19:
SP20:
SP21: - - - - - -

ExUns: 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ·
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - - - - - - - - - - - - - - - - - - - - - - - -
SP18:
SP19:
SP20:
SP21:

Relevant External Links for CDK16 Gene

GeneLoc Exon Structure for
CDK16
ECgene alternative splicing isoforms for
CDK16

Expression for CDK16 Gene

mRNA expression in normal human tissues for CDK16 Gene

Protein differential expression in normal tissues from HIPED for CDK16 Gene

This gene is overexpressed in Plasma (20.4), Testis (15.1), Fetal Brain (12.1), and Heart (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK16 Gene



SOURCE GeneReport for Unigene cluster for CDK16 Gene Hs.496068

mRNA Expression by UniProt/SwissProt for CDK16 Gene

Q00536-CDK16_HUMAN
Tissue specificity: Detected in pancreas islets (at protein level). Detected in brain and pancreas.
genes like me logo Genes that share expression patterns with CDK16: view

Protein tissue co-expression partners for CDK16 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK16 Gene

Orthologs for CDK16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDK16 35
  • 94.89 (n)
  • 97.98 (a)
PCTK1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK16 35
  • 91.11 (n)
  • 92.11 (a)
CDK16 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk16 35
  • 91.87 (n)
  • 97.58 (a)
Cdk16 16
Cdk16 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDK16 35
  • 99.76 (n)
  • 100 (a)
CDK16 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk16 35
  • 91.6 (n)
  • 97.58 (a)
oppossum
(Monodelphis domestica)
Mammalia CDK16 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK16 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK16 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk16 35
  • 76.13 (n)
  • 86.92 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21411 35
zebrafish
(Danio rerio)
Actinopterygii cdk16 35
  • 71.99 (n)
  • 80.5 (a)
cdk16 36
  • 74 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pct-1 36
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 36
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10414 36
  • 58 (a)
OneToMany
Species with no ortholog for CDK16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK16 Gene

ENSEMBL:
Gene Tree for CDK16 (if available)
TreeFam:
Gene Tree for CDK16 (if available)

Paralogs for CDK16 Gene

Paralogs for CDK16 Gene

Pseudogenes.org Pseudogenes for CDK16 Gene

genes like me logo Genes that share paralogs with CDK16: view

Variants for CDK16 Gene

Sequence variations from dbSNP and Humsavar for CDK16 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs10617 -- 47,229,247(+) TTTTT(G/T)TTTGT utr-variant-3-prime, nc-transcript-variant
rs1058465 -- 47,228,756(+) GTGGA(A/C)ACCGA missense, reference, intron-variant, nc-transcript-variant
rs1058513 -- 47,228,917(+) CCAAA(A/C)ACCCC utr-variant-3-prime, intron-variant, nc-transcript-variant
rs2273272 -- 47,223,787(-) CCATA(C/T)GGGAG intron-variant
rs5902386 -- 47,227,283(+) AGGGA(-/C)CCCCC intron-variant

Variation tolerance for CDK16 Gene

Residual Variation Intolerance Score: 11.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK16 Gene

HapMap Linkage Disequilibrium report
CDK16
Human Gene Mutation Database (HGMD)
CDK16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDK16 Gene

Disorders for CDK16 Gene

Relevant External Links for CDK16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK16
genes like me logo Genes that share disorders with CDK16: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK16 Gene

Publications for CDK16 Gene

  1. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 67
  2. An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport. (PMID: 16461467) Tang X. … Czech M.P. (Proc. Natl. Acad. Sci. U.S.A. 2006) 23 67
  3. Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. (PMID: 12154078) Graeser R. … Hunt T. (J. Cell. Sci. 2002) 23 67
  4. UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2. (PMID: 9801870) Brandau O. … Meindl A. (Eur. J. Hum. Genet. 1998) 23 67
  5. X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse. (PMID: 8852665) Carrel L. … Willard H.F. (Hum. Mol. Genet. 1996) 23 67

Products for CDK16 Gene

Sources for CDK16 Gene

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