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Aliases for CDK16 Gene

Aliases for CDK16 Gene

  • Cyclin-Dependent Kinase 16 2 3
  • PCTAIRE1 3 4 6
  • PCTK1 3 4 6
  • Serine/Threonine-Protein Kinase PCTAIRE-1 3 4
  • Cell Division Protein Kinase 16 3 4
  • PCTAIRE-Motif Protein Kinase 1 3 4
  • EC 2.7.11.22 4 63
  • Serine/Threonine-Protein Kinase 2
  • PCTAIRE Protein Kinase 1 2
  • EC 2.7.11 63
  • PCTGAIRE 3
  • PCTAIRE 3

External Ids for CDK16 Gene

Previous HGNC Symbols for CDK16 Gene

  • PCTK1

Previous GeneCards Identifiers for CDK16 Gene

  • GC0XP046963
  • GC0XP047078
  • GC0XP044787
  • GC0XP047079

Summaries for CDK16 Gene

Entrez Gene Summary for CDK16 Gene

  • The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

GeneCards Summary for CDK16 Gene

CDK16 (Cyclin-Dependent Kinase 16) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK15.

UniProtKB/Swiss-Prot for CDK16 Gene

  • Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at Ser-336 (in vitro).

Gene Wiki entry for CDK16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK16 Gene

Genomics for CDK16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDK16 Gene

Start:
47,217,860 bp from pter
End:
47,229,997 bp from pter
Size:
12,138 bases
Orientation:
Plus strand

Genomic View for CDK16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK16 Gene

No data available for Regulatory Elements for CDK16 Gene

Proteins for CDK16 Gene

  • Protein details for CDK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00536-CDK16_HUMAN
    Recommended name:
    Cyclin-dependent kinase 16
    Protein Accession:
    Q00536
    Secondary Accessions:
    • A8K280
    • B7Z7C8
    • J3KN74
    • J3KQP7

    Protein attributes for CDK16 Gene

    Size:
    496 amino acids
    Molecular mass:
    55716 Da
    Quaternary structure:
    • Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ. Interacts with NSF. Identified in a complex with NSF, syntaxin-1, synaptotagmin, SYN1, SYP and CDK5R1 (By similarity). Interacts with BRSK2. Interacts with CCNY; this increases the CDK16 kinase activity.
    SequenceCaution:
    • Sequence=AAH01048.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15607.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK16 Gene

    Alternative splice isoforms for CDK16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK16 Gene

Proteomics data for CDK16 Gene at MOPED

Post-translational modifications for CDK16 Gene

  • Phosphorylation at Ser-153 inhibits kinase activity.
  • Ubiquitination at Lys133, Lys143, Lys167, Lys194, Lys455, and Lys466
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK16 (CDK16)

Domains for CDK16 Gene

Gene Families for CDK16 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q00536

UniProtKB/Swiss-Prot:

CDK16_HUMAN :
  • Q00536
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK16: view

Function for CDK16 Gene

Molecular function for CDK16 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at Ser-336 (in vitro).

Enzyme Numbers (IUBMB) for CDK16 Gene

Gene Ontology (GO) - Molecular Function for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 22184064
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16091426
genes like me logo Genes that share ontologies with CDK16: view

Phenotypes for CDK16 Gene

genes like me logo Genes that share phenotypes with CDK16: view

Animal Models for CDK16 Gene

MGI Knock Outs for CDK16:

Animal Model Products

miRNA for CDK16 Gene

miRTarBase miRNAs that target CDK16

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK16

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CDK16 Gene

Localization for CDK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK16 Gene

Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK16 Gene COMPARTMENTS Subcellular localization image for CDK16 gene
Compartment Confidence
plasma membrane 5
cytosol 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0008021 colocalizes_with synaptic vesicle ISS --
GO:0015630 microtubule cytoskeleton IDA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with CDK16: view

Pathways for CDK16 Gene

genes like me logo Genes that share pathways with CDK16: view

Pathways by source for CDK16 Gene

2 Qiagen pathways for CDK16 Gene
1 Cell Signaling Technology pathway for CDK16 Gene
1 GeneGo (Thomson Reuters) pathway for CDK16 Gene

Gene Ontology (GO) - Biological Process for CDK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006887 exocytosis ISS --
GO:0007283 spermatogenesis ISS --
GO:0030252 growth hormone secretion ISS --
GO:0031175 neuron projection development ISS --
genes like me logo Genes that share ontologies with CDK16: view

Compounds for CDK16 Gene

(1) Drugbank Compounds for CDK16 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
target
genes like me logo Genes that share compounds with CDK16: view

Transcripts for CDK16 Gene

Unigene Clusters for CDK16 Gene

Cyclin-dependent kinase 16:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK16

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK16 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8: - - - -
SP9: -
SP10:
SP11: - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - - - - - - - -
SP15: - - - -
SP16: - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - -
SP19:
SP20:
SP21: - - - - - -

ExUns: 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ·
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - - - - - - - - - - - - - - - - - - - - - - - -
SP18:
SP19:
SP20:
SP21:

Relevant External Links for CDK16 Gene

GeneLoc Exon Structure for
CDK16
ECgene alternative splicing isoforms for
CDK16

Expression for CDK16 Gene

mRNA expression in normal human tissues for CDK16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK16 Gene

SOURCE GeneReport for Unigene cluster for CDK16 Gene Hs.496068

mRNA Expression by UniProt/SwissProt for CDK16 Gene

Q00536-CDK16_HUMAN
Tissue specificity: Detected in pancreas islets (at protein level). Detected in brain and pancreas.
genes like me logo Genes that share expressions with CDK16: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDK16 Gene

Orthologs for CDK16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK16 35
  • 99.76 (n)
  • 100 (a)
CDK16 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK16 35
  • 94.89 (n)
  • 97.98 (a)
PCTK1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK16 35
  • 91.11 (n)
  • 92.11 (a)
CDK16 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk16 35
  • 91.87 (n)
  • 97.58 (a)
Cdk16 16
Cdk16 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK16 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK16 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk16 35
  • 91.6 (n)
  • 97.58 (a)
lizard
(Anolis carolinensis)
Reptilia CDK16 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21411 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk16 35
  • 76.13 (n)
  • 86.92 (a)
zebrafish
(Danio rerio)
Actinopterygii cdk16 35
  • 71.99 (n)
  • 80.5 (a)
cdk16 36
  • 74 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pct-1 36
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 36
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10414 36
  • 58 (a)
OneToMany
Species with no ortholog for CDK16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK16 Gene

ENSEMBL:
Gene Tree for CDK16 (if available)
TreeFam:
Gene Tree for CDK16 (if available)

Paralogs for CDK16 Gene

Paralogs for CDK16 Gene

Pseudogenes.org Pseudogenes for CDK16 Gene

genes like me logo Genes that share paralogs with CDK16: view

Variants for CDK16 Gene

Sequence variations from dbSNP and Humsavar for CDK16 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs10617 -- 47,229,247(+) TTTTT(G/T)TTTGT utr-variant-3-prime
rs1058465 -- 47,228,756(+) GTGGA(A/C)ACCGA missense, reference
rs1058513 -- 47,228,917(+) CCAAA(A/C)ACCCC utr-variant-3-prime
rs2273272 -- 47,223,787(-) CCATA(C/T)GGGAG intron-variant
rs5902386 -- 47,227,283(+) AGGGA(-/C)CCCCC intron-variant

Relevant External Links for CDK16 Gene

HapMap Linkage Disequilibrium report
CDK16
Human Gene Mutation Database (HGMD)
CDK16
Locus Specific Mutation Databases (LSDB)
CDK16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDK16 Gene

Disorders for CDK16 Gene

No disorders were found for CDK16 Gene.

No data available for UniProtKB/Swiss-Prot for CDK16 Gene

Publications for CDK16 Gene

  1. PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. (PMID: 1437147) Okuda T. … Downing J.R. (Oncogene 1992) 2 3
  2. A family of human cdc2-related protein kinases. (PMID: 1639063) Meyerson M. … Tsai L.-H. (EMBO J. 1992) 3 4
  3. Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3. (PMID: 7656587) Knight J.C. … Okuda T. (Cytogenet. Cell Genet. 1995) 3 23
  4. Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. (PMID: 8088790) Okuda T. … Downing J.R. (Genomics 1994) 3 23
  5. X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse. (PMID: 8852665) Carrel L. … Willard H.F. (Hum. Mol. Genet. 1996) 3 23

Products for CDK16 Gene

  • Addgene plasmids for CDK16

Sources for CDK16 Gene

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