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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK15 Gene

protein-coding   GIFtS: 50
GCID: GC02P202656

cyclin-dependent kinase 15

(Previous names: amyotrophic lateral sclerosis 2 (juvenile) chromosome region,...)
(Previous symbols: ALS2CR7, PFTK2)
 Explore 3 diseases affiliated with
CDK15 via our new
 Human Malady Compendium 
Biological research products
for CDK15
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 151 2     Cell Division Protein Kinase 152 3
ALS2CR71 2 3     Serine/Threonine-Protein Kinase ALS2CR72 3
PFTK21 2 3     Serine/Threonine-Protein Kinase PFTAIRE-22 3
PFTAIRE21 2     EC 2.7.11.223 8
Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 71 2     Serine/Threonine Protein Kinase2
PFTAIRE Protein Kinase 21 2     EC 2.7.118
Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 7 Protein2 3     

External Ids:    HGNC: 144341   Entrez Gene: 650612   Ensembl: ENSG000001383957   UniProtKB: Q96Q403   

Export aliases for CDK15 gene to outside databases

Previous GC identifers: GC02P202382 GC02P194519


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CDK15_HUMAN, Q96Q40
Function: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is
controlled by an associated cyclin (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK15
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK15 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.2   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.2

CDK15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK15 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P202656:  view genomic region     (about GC identifiers)

Start:
202,655,184 bp from pter      End:
202,760,273 bp from pter
Size:
105,090 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDK15_HUMAN, Q96Q40 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 15  
Size: 435 amino acids; 49023 Da
Cofactor: Magnesium (By similarity)
Sequence caution: Sequence=BAD18656.1; Type=Erroneous initiation;
Secondary accessions: A8K8R9 B8ZZX0 C9J1N8 C9K003 Q4ZG86 Q53TV1 Q6ZMR9 Q8IUP1
Alternative splicing: 4 isoforms:  Q96Q40-1   Q96Q40-2   Q96Q40-3   Q96Q40-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK15: NX_Q96Q40

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96Q40

  • 4/8 DME Specific Peptides for CDK15 (Q96Q40) (see all 8)
     LADFGLA  VVTLWYR  LKHANIV  DFGLARA 

    CDK15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001248364.1  NP_001248365.1  NP_631897.1  

    ENSEMBL proteins: 
     ENSP00000389831   ENSP00000386901   ENSP00000260967   ENSP00000406472   ENSP00000412775  
     ENSP00000363726  

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    Uscn Proteins for CDK15


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    Uscn ELISAs and CLIAs for CDK15


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CDK15 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q96Q40

    ProtoNet protein and cluster: Q96Q40

    1 Blocks protein family: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: CDK15_HUMAN, Q96Q40
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CDK15_HUMAN, Q96Q40
    Function: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is
    controlled by an associated cyclin (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

    Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein kinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--


    CDK15 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CDK15:
     Increased cell death in breast  Increased mitotic index 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK15

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/6 Interacting proteins for CDK15 (Q96Q401, 2, 3 ENSP000002609674) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249413, ENSP000002669704I2D: score=2 STRING: ENSP00000266970
    RASSF5Q8WWW03I2D: score=1 
    STK4Q130433I2D: score=1 
    HSP90AB1P082381EBI-1051975,EBI-352572
    CENPKENSP000002428724STRING: ENSP00000242872
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK15

    1 HMDB Compound for CDK15    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for CDK15    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about CDK15 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK15 gene (3 alternative transcripts): 
    NM_001261435.1  NM_001261436.1  NM_139158.2  

    Unigene Cluster for CDK15:

    Cyclin-dependent kinase 15
    Hs.348711  [show with all ESTs]
    Unigene Representative Sequence: BX647394
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451080(uc010ftm.3) ENST00000410091(uc002uys.2) ENST00000493754
    ENST00000260967(uc010ftn.1) ENST00000488419(uc010fto.1) ENST00000450471(uc002uyt.2)
    ENST00000434439 ENST00000460149 ENST00000466337 ENST00000374598(uc002uyu.1)


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    Inhib. RNA
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    Additional cDNA sequence: 

    AB053308.1 AK091710.1 AK131512.1 AK292434.1 AK310050.1 BC038807.1 BX647394.1 

    7 DOTS entries:

    DT.100657408  DT.101967618  DT.308931  DT.95110803  DT.102836181  DT.40301046  DT.91657820 

    24/41 AceView cDNA sequences (see all 41):

    AI276750 AB053308 AX772791 BC038807 NM_139158 AA436054 BX095314 AK131512 
    AA405329 AA759053 BE562611 BX283916 BX647394 CD636738 W03371 CD636736 
    BQ694852 AA405146 BE672851 AK091710 BI755983 AA435956 AI028242 CD636753 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CDK15    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
    SP1:        -     -                                                     -           -                 -                                 
    SP2:                                                                    -           -                 -     -                           
    SP3:                                                                    -           -                                                   
    SP4:                                            -                       -                                                               
    SP5:                                                                                -     -           -                                 


    ECgene alternative splicing isoforms for CDK15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CDK15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK15

    SOURCE GeneReport for Unigene cluster: Hs.348711
        SABiosciences Custom PCR Arrays for CDK15
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK15 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CDK156
    Uncharacterized protein
    69(a)
    1 ↔ 1
    7(12643464-12676391)
    lizard
    (Anolis carolinensis)
    Reptilia CDK156
    --
    63(a)
    1 ↔ 1
    GL343478.1(31546-65328)
    zebrafish
    (Danio rerio)
    Actinopterygii cdk151 cyclin-dependent kinase 15 65.7(n)
    66.75(a)
      791619  NM_001040308.1  NP_001035398.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eip63E6
    Ecdysone-induced protein 63E
    40(a)
    1 → many
    3L(3515751-3610521)
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-26
    ZC123.46
    Protein ZC123.4, isoform c
    33(a)
    27(a)
    possible ortholog
    1 ↔ many
    I(3408035-3415072)
    I(841749-846766)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CDKA16
    CDKB1;26
    (see all 5)
    cyclin-dependent kinase B1-2
    (see all 5)
    46(a)
    43(a)
    (see all 5)
    1 ↔ many
    possible ortholog
    (see all 5)
    3(18071536-18074641)
    2(16152505-16154086)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 5)
    cyclin-dependent kinase A-1, putative, expressed
    (see all 5)
    42(a)
    41(a)
    (see all 5)
    possible ortholog
    many ↔ many
    (see all 5)
    1(38980259-38983035)
    3(996598-1000241)


    ENSEMBL Gene Tree for CDK15 (if available)
    TreeFam Gene Tree for CDK15 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK15 gene
    CDK62  CDK182  CDK52  CDK42  CDK12  CDK32  CDK142  CDK162  
    CDK22  CDK172  
    18/51 SIMAP similar genes for CDK15 using alignment to 3 protein entries:     CDK15_HUMAN (see all proteins) (see all similar genes):
    PCTK3    CDK18    CDK16    PCTK1    CDK5    CDK14
    CDK3    CDK17    CDK1    CDC2    DKFZp686L20222    CDK7
    RPS6KA2    CDK10    CDK4    CDK20    CDK6    MAK

    CDK15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1492 NCBI SNPs in CDK15 are shown (see all 1492    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs558802531,2
    C--202669204(+) AAAAAA/-GTAGT 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1932006031,2
    --202669221(+) AAGTAG/TTTAAT 1 -- us2k10--------
    rs794908311,2
    --202669325(+) AGGAGG/TATCGC 3 -- us2k10--------
    rs1851711451,2
    --202669410(+) CCAGGC/TATGGT 3 -- us2k10--------
    rs1884891871,2
    --202669418(+) GGTGGC/TGTGCA 3 -- us2k10--------
    rs1455655131,2
    C,--202669495(+) GCCTA-/GGCAAC 3 -- us2k10--------
    rs1142272941,2
    F,--202669598(+) ACTGAG/ACCCAG 3 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1927330211,2
    --202669824(+) TCAAAG/TGGAAT 3 -- us2k10--------
    rs1838738111,2
    --202669865(+) TCTCAG/TTTGTC 3 -- us2k10--------
    rs1882712251,2
    --202669902(+) GGGTGC/TGGTGG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK15 (202655184 - 202760273 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for CDK15
         2 CNVs: 63277 63278
         6 Indels: 45930 42770 26538 61877 98104 12116

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK15
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDK15 for disorders           About GeneDecksing

    3 diseases for CDK15:    About MalaCards
    amyotrophic lateral sclerosis    lateral sclerosis    malaria


    Export disorders for CDK15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK15 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CDK15)
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    1. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PubMed id 11586298)1, 2, 3 Hadano S....Ikeda J.-E. (2001)
    2. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. Mammalian cyclin-dependent kinases. (PubMed id 16236519)1, 3 Malumbres M. and Barbacid M. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (2002)
    8. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    9. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    10. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65061 HGNC: 14434 AceView: ALS2CR7 Ensembl:ENSG00000138395 euGenes: HUgn65061
    ECgene: CDK15 H-InvDB: CDK15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK15 gene:
    Search GeneIP for patents involving CDK15

    GeneCards and IP:
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