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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK15 Gene

protein-coding   GIFtS: 53
GCID: GC02P202656

Cyclin-Dependent Kinase 15

(Previous names: amyotrophic lateral sclerosis 2 (juvenile) chromosome region,...)
(Previous symbols: ALS2CR7, PFTK2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 151 2     Serine/Threonine-Protein Kinase ALS2CR72 3
ALS2CR71 2 3     Serine/Threonine-Protein Kinase PFTAIRE-22 3
PFTK21 2 3     EC 2.7.11.223 8
Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 71 2     PFTAIRE22
PFTAIRE Protein Kinase 21 2     Serine/Threonine Protein Kinase2
Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 7
Protein2 3
     EC 2.7.118
Cell Division Protein Kinase 152 3     

External Ids:    HGNC: 144341   Entrez Gene: 650612   Ensembl: ENSG000001383957   UniProtKB: Q96Q403   

Export aliases for CDK15 gene to outside databases

Previous GC identifers: GC02P202382 GC02P194519


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CDK15 Gene: 
CDK15 (cyclin-dependent kinase 15) is a protein-coding gene. Diseases associated with CDK15 include lateral sclerosis, and amyotrophic lateral sclerosis. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity and metal ion binding. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK15_HUMAN, Q96Q40
Function: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is
controlled by an associated cyclin (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK15
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK15 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.2   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.2

CDK15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK15 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P202656:  view genomic region     (about GC identifiers)

Start:
202,655,184 bp from pter      End:
202,760,273 bp from pter
Size:
105,090 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK15_HUMAN, Q96Q40 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 15  
Size: 435 amino acids; 49023 Da
Cofactor: Magnesium (By similarity)
Sequence caution: Sequence=BAD18656.1; Type=Erroneous initiation;
Secondary accessions: A8K8R9 B8ZZX0 C9J1N8 C9K003 F8W6H8 Q4ZG86 Q53TV1 Q6ZMR9 Q8IUP1
Alternative splicing: 5 isoforms:  Q96Q40-1   Q96Q40-2   Q96Q40-3   Q96Q40-4   Q96Q40-5   (Gene prediction based on EST data. May be due to competing acceptor splice site)

Explore the universe of human proteins at neXtProt for CDK15: NX_Q96Q40

Explore proteomics data for CDK15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96Q40

  • 4/8 DME Specific Peptides for CDK15 (Q96Q40) (see all 8)
     LADFGLA  VVTLWYR  LKHANIV  DFGLARA 

    CDK15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK15 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001248364.1  NP_001248365.1  NP_631897.1  

    ENSEMBL proteins: 
     ENSP00000389831   ENSP00000386901   ENSP00000260967   ENSP00000406472   ENSP00000412775  
     ENSP00000363726  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 15 
    TAIRE subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q96Q40

    ProtoNet protein and cluster: Q96Q40

    1 Blocks protein domain: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: CDK15_HUMAN, Q96Q40
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK15_HUMAN, Q96Q40
    Function: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is
    controlled by an associated cyclin (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    CDK15 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDK15:
     Increased cell death in breast  Increased mitotic index 

         1 MGI phenotypic allele for Cdk15 (no phenotypes)

    CDK15 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK15 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK15 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK15 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK15

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/6 Interacting proteins for CDK15 (Q96Q401, 2, 3 ENSP000002609674) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249413, ENSP000002669704I2D: score=2 STRING: ENSP00000266970
    RASSF5Q8WWW03I2D: score=1 
    STK4Q130433I2D: score=1 
    HSP90AB1P082381EBI-1051975,EBI-352572
    CENPKENSP000002428724STRING: ENSP00000242872
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    CDK15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK15

    1 HMDB Compound for CDK15    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for CDK15    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about CDK15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK15 gene (3 alternative transcripts): 
    NM_001261435.1  NM_001261436.1  NM_139158.2  

    Unigene Cluster for CDK15:

    Cyclin-dependent kinase 15
    Hs.348711  [show with all ESTs]
    Unigene Representative Sequence: BX647394
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451080(uc010ftm.3) ENST00000410091(uc002uys.2) ENST00000493754
    ENST00000260967(uc010ftn.1) ENST00000488419(uc010fto.1) ENST00000450471(uc002uyt.2)
    ENST00000434439 ENST00000460149 ENST00000466337 ENST00000374598(uc002uyu.1)

    miRNA
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    Additional mRNA sequence: 

    AB053308.1 AK091710.1 AK131512.1 AK292434.1 AK310050.1 BC038807.1 BX647394.1 

    7 DOTS entries:

    DT.100657408  DT.101967618  DT.308931  DT.95110803  DT.102836181  DT.40301046  DT.91657820 

    24/41 AceView cDNA sequences (see all 41):

    AX772791 AA436054 BX095314 AA759053 AK131512 AB053308 NM_139158 AI276750 
    AA405329 BC038807 W03371 BE562611 CD636736 BX647394 AI028242 AK091710 
    AA435956 CD636738 BI755983 BE672851 BX283916 AA405146 BQ694852 CD636757 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CDK15    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
    SP1:        -     -                                                     -           -                 -                                 
    SP2:                                                                    -           -                 -     -                           
    SP3:                                                                    -           -                                                   
    SP4:                                            -                       -                                                               
    SP5:                                                                                -     -           -                                 


    ECgene alternative splicing isoforms for CDK15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK15 expression in normal human tissues (normalized intensities)      CDK15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDK15 Expression
    About this image


    CDK15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived mesenchymal stem cells
     
     Blood (Hematopoietic System)
             Umbilical cord blood-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Umbilical cord blood-derived mesenchymal stem cells

    See CDK15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK15

    SOURCE GeneReport for Unigene cluster: Hs.348711
        SABiosciences Custom PCR Arrays for CDK15
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK15 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk151 , 5 cyclin-dependent kinase 151, 5 89.79(n)1
    92.15(a)1
      1 (29.47 cM)5
    2716971  NM_001033373.21  NP_001028545.21 
     592569065 
    chicken
    (Gallus gallus)
    Aves CDK156
    cyclin-dependent kinase 15
    72(a)
    1 ↔ 1
    7(11084221-11117761)
    lizard
    (Anolis carolinensis)
    Reptilia CDK156
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343478.1(31546-65328)
    zebrafish
    (Danio rerio)
    Actinopterygii cdk151 cyclin-dependent kinase 15 65.7(n)
    66.75(a)
      791619  NM_001040308.1  NP_001035398.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eip63E6
    Ecdysone-induced protein 63E
    40(a)
    1 → many
    3L(3515751-3610521)
    worm
    (Caenorhabditis elegans)
    Secernentea ZC123.46
    Protein ZC123.4, isoform a
    29(a)
    possible ortholog
    I(841746-846763)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO856
    Cyclin-dependent kinase, with ten cyclin partners;...
    48(a)
    1 → many
    XVI(492018-493037)


    ENSEMBL Gene Tree for CDK15 (if available)
    TreeFam Gene Tree for CDK15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK15 gene
    CDK182  CDK62  CDK52  CDK12  CDK42  CDK32  CDK142  CDK162  
    CDK22  CDK172  
    18/38 SIMAP similar genes for CDK15 using alignment to 2 protein entries:     CDK15_HUMAN (see all proteins) (see all similar genes):
    CDK14    PCTK3    CDK16    PCTK1    CDK18    CDK5
    CDK3    CDK17    CDK1    CDC2    DKFZp686L20222    CDK7
    CDK4    CDK10    CDK2    CDK20    CDK6    MAK

    CDK15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1777 SNPs in CDK15 are shown (see all 1777)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0420204
    A breast infiltrating ductal carcinoma sample4--see VAR_0420202 E D mis40--------
    VAR_0420174
    A renal clear cell carcinoma sample4--see VAR_0420172 K E mis40--------
    rs2000429621,2
    C--202669203(+) CGGAAA/GAAAAA 1 -- us2k10--------
    rs1932006031,2
    --202669221(+) AAGTAG/TTTAAT 1 -- us2k10--------
    rs794908311,2
    --202669325(+) AGGAGG/TATCGC 3 -- us2k10--------
    rs1851711451,2
    --202669410(+) CCAGGC/TATGGT 3 -- us2k10--------
    rs1884891871,2
    --202669418(+) GGTGGC/TGTGCA 3 -- us2k10--------
    rs1455655131,2
    C--202669495(+) GCCTA-/GGCAAC 3 -- us2k10--------
    rs1142272941,2
    C,F--202669598(+) ACTGAG/ACCCAG 3 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1927330211,2
    --202669824(+) TCAAAG/TGGAAT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK15 (202655184 - 202760273 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for CDK15 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2767CNV Deletion18987735
    esv2585128CNV Deletion19546169
    esv2616659CNV Deletion19546169
    esv1175048CNV Deletion17803354
    esv993740CNV Deletion20482838
    esv2033442CNV Deletion18987734
    esv996523CNV Deletion20482838
    esv2721367CNV Deletion23290073
    nsv834511CNV Loss17160897
    esv9186CNV Loss19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CDK15:    About MalaCards
    lateral sclerosis    amyotrophic lateral sclerosis


    CDK15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDK15

    Export disorders for CDK15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK15 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with CDK15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PubMed id 11586298)1, 2, 3 Hadano S....Ikeda J.-E. (2001)
    2. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. Mammalian cyclin-dependent kinases. (PubMed id 16236519)1, 3 Malumbres M. and Barbacid M. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (2002)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    10. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65061 HGNC: 14434 AceView: ALS2CR7 Ensembl:ENSG00000138395 euGenes: HUgn65061
    ECgene: CDK15 H-InvDB: CDK15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK15 gene:
    Search GeneIP for patents involving CDK15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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