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Aliases for CDK15 Gene

Aliases for CDK15 Gene

  • Cyclin-Dependent Kinase 15 2 3
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 7 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 7 2 3
  • Serine/Threonine-Protein Kinase PFTAIRE-2 3 4
  • Serine/Threonine-Protein Kinase ALS2CR7 3 4
  • Cell Division Protein Kinase 15 3 4
  • PFTAIRE Protein Kinase 2 2 3
  • EC 4 63
  • ALS2CR7 3 4
  • PFTK2 3 4
  • Serine/Threonine Protein Kinase 3
  • EC 2.7.11 63
  • PFTAIRE2 3

External Ids for CDK15 Gene

Previous HGNC Symbols for CDK15 Gene

  • ALS2CR7
  • PFTK2

Previous GeneCards Identifiers for CDK15 Gene

  • GC02P202382
  • GC02P202656
  • GC02P194519

Summaries for CDK15 Gene

GeneCards Summary for CDK15 Gene

CDK15 (Cyclin-Dependent Kinase 15) is a Protein Coding gene. Diseases associated with CDK15 include lateral sclerosis. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK5.

UniProtKB/Swiss-Prot for CDK15 Gene

  • Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at Thr-34.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK15 Gene

Genomics for CDK15 Gene

Genomic Location for CDK15 Gene

201,790,454 bp from pter
201,895,550 bp from pter
105,097 bases
Plus strand

Genomic View for CDK15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK15 Gene

No data available for Regulatory Elements for CDK15 Gene

Proteins for CDK15 Gene

  • Protein details for CDK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase 15
    Protein Accession:
    Secondary Accessions:
    • A8K8R9
    • B8ZZX0
    • C9J1N8
    • C9K003
    • F8W6H8
    • Q4ZG86
    • Q53TV1
    • Q6ZMR9
    • Q8IUP1

    Protein attributes for CDK15 Gene

    435 amino acids
    Molecular mass:
    49023 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=BAD18656.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK15 Gene


neXtProt entry for CDK15 Gene

Proteomics data for CDK15 Gene at MOPED

Selected DME Specific Peptides for CDK15 Gene

Post-translational modifications for CDK15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK15 Gene

Antibody Products

Domains for CDK15 Gene

Gene Families for CDK15 Gene

  • CDK :Cyclin-dependent kinases

Suggested Antigen Peptide Sequences for CDK15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96Q40
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK15: view

Function for CDK15 Gene

Molecular function for CDK15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at Thr-34.

Enzyme Numbers (IUBMB) for CDK15 Gene

Gene Ontology (GO) - Molecular Function for CDK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 24866247
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 22939624
genes like me logo Genes that share ontologies with CDK15: view

Phenotypes for CDK15 Gene

genes like me logo Genes that share phenotypes with CDK15: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK15

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDK15 Gene

Localization for CDK15 Gene

Subcellular locations from

Jensen Localization Image for CDK15 Gene COMPARTMENTS Subcellular localization image for CDK15 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDK15 Gene

Pathways for CDK15 Gene

SuperPathways for CDK15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDK15: view

No data available for Pathways by source for CDK15 Gene

Compounds for CDK15 Gene

(1) HMDB Compounds for CDK15 Gene

Compound Synonyms Cas Number PubMed IDs
  • Magnesium

(1) Drugbank Compounds for CDK15 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine triphosphate
  • 5'-ATP
56-65-5 target
genes like me logo Genes that share compounds with CDK15: view

Transcripts for CDK15 Gene

Unigene Clusters for CDK15 Gene

Cyclin-dependent kinase 15:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK15

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK15 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for CDK15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDK15 Gene

mRNA expression in normal human tissues for CDK15 Gene

mRNA differential expression in normal tissues according to GTEx for CDK15 Gene

This gene is overexpressed in Ovary (8.8).

Protein differential expression in normal tissues for CDK15 Gene

This gene is overexpressed in Heart (35.9) and Brain (33.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDK15 Gene

SOURCE GeneReport for Unigene cluster for CDK15 Gene Hs.348711

genes like me logo Genes that share expressions with CDK15: view

Expression partners for CDK15 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CDK15 Gene

Orthologs for CDK15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDK15 35
  • 90.19 (n)
  • 90.65 (a)
(Canis familiaris)
Mammalia CDK15 35
  • 93.08 (n)
  • 92.54 (a)
CDK15 36
  • 91 (a)
(Mus musculus)
Mammalia Cdk15 35
  • 89.12 (n)
  • 90.61 (a)
Cdk15 16
Cdk15 36
  • 89 (a)
(Pan troglodytes)
Mammalia CDK15 35
  • 99.15 (n)
  • 98.83 (a)
CDK15 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Fzd7 35
  • 84.23 (n)
  • 85.78 (a)
(Monodelphis domestica)
Mammalia CDK15 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia CDK15 36
  • 71 (a)
(Gallus gallus)
Aves CDK15 35
  • 71.81 (n)
  • 69.41 (a)
CDK15 36
  • 72 (a)
(Anolis carolinensis)
Reptilia CDK15 36
  • 67 (a)
(Danio rerio)
Actinopterygii cdk15 35
  • 65.95 (n)
  • 67.11 (a)
cdk15 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Eip63E 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea ZC123.4 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 36
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10643 36
  • 54 (a)
Species with no ortholog for CDK15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CDK15 Gene

Gene Tree for CDK15 (if available)
Gene Tree for CDK15 (if available)

Paralogs for CDK15 Gene

Paralogs for CDK15 Gene

genes like me logo Genes that share paralogs with CDK15: view

Variants for CDK15 Gene

Sequence variations from dbSNP and Humsavar for CDK15 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs16698 -- 201,843,666(+) CGTGT(-/NN)ATATA intron-variant
rs193598 -- 201,845,479(-) CCACT(A/G)TGCCT intron-variant
rs193599 -- 201,834,478(-) ATACA(A/G)TGATA intron-variant
rs193600 -- 201,832,300(-) GGAAG(A/G)CCAAA intron-variant
rs193601 -- 201,832,288(-) CGAGC(C/G/T)GATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK15 Gene

Variant ID Type Subtype PubMed ID
nsv524548 CNV Gain 19592680
nsv875710 CNV Gain 21882294
nsv834511 CNV Loss 17160897
nsv527313 CNV Loss 19592680
esv2616659 CNV Deletion 19546169
esv2033442 CNV Deletion 18987734
esv2767 CNV Deletion 18987735
esv2721367 CNV Deletion 23290073
nsv215499 CNV Loss 16902084
esv996523 CNV Deletion 20482838
esv9186 CNV Loss 19470904
esv2585128 CNV Deletion 19546169
esv1175048 CNV Deletion 17803354
esv993740 CNV Deletion 20482838
esv1004233 CNV Loss 20482838
esv1007353 CNV Loss 20482838
esv22656 CNV Loss 19812545
esv992519 CNV Gain 20482838
esv23406 CNV Gain 19812545

Relevant External Links for CDK15 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK15 Gene

Disorders for CDK15 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CDK15 Gene in MalaCards »

(1) Diseases for CDK15 Gene including...

Relevant External Links for CDK15

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with CDK15: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CDK15 Gene

Publications for CDK15 Gene

  1. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PMID: 11586298) Hadano S. … Ikeda J.-E. (Nat. Genet. 2001) 2 3 4
  2. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for CDK15 Gene

  • Addgene plasmids for CDK15

Sources for CDK15 Gene

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