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CDK15 Gene

protein-coding   GIFtS: 51
GCID: GC02P202656

Cyclin-Dependent Kinase 15

(Previous names: amyotrophic lateral sclerosis 2 (juvenile) chromosome region,...)
(Previous symbols: ALS2CR7, PFTK2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 151 2     Serine/Threonine-Protein Kinase ALS2CR72 3
ALS2CR71 2 3     Serine/Threonine-Protein Kinase PFTAIRE-22 3
PFTK21 2 3     EC 2.7.11.223 8
Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 71 2     PFTAIRE22
PFTAIRE Protein Kinase 21 2     Serine/Threonine Protein Kinase2
Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 7
Protein2 3
     EC 2.7.118
Cell Division Protein Kinase 152 3     

External Ids:    HGNC: 144341   Entrez Gene: 650612   Ensembl: ENSG000001383957   UniProtKB: Q96Q403   

Export aliases for CDK15 gene to outside databases

Previous GC identifers: GC02P202382 GC02P194519


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CDK15 Gene:
CDK15 (cyclin-dependent kinase 15) is a protein-coding gene. Diseases associated with CDK15 include amyotrophic lateral sclerosis 2, juvenile, and lateral sclerosis. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK15_HUMAN, Q96Q40
Function: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is
controlled by an associated cyclin (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CDK15
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDK15 promoter sequence
   Search Chromatin IP Primers for CDK15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.2   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.2

CDK15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK15 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P202656:  view genomic region     (about GC identifiers)

Start:
202,655,184 bp from pter      End:
202,760,273 bp from pter
Size:
105,090 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDK15_HUMAN, Q96Q40 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 15  
Size: 435 amino acids; 49023 Da
Cofactor: Magnesium (By similarity)
Sequence caution: Sequence=BAD18656.1; Type=Erroneous initiation;
Secondary accessions: A8K8R9 B8ZZX0 C9J1N8 C9K003 F8W6H8 Q4ZG86 Q53TV1 Q6ZMR9 Q8IUP1
Alternative splicing: 5 isoforms:  Q96Q40-1   Q96Q40-2   Q96Q40-3   Q96Q40-4   Q96Q40-5   (Gene prediction based on EST data. May be due to competing acceptor splice site)

Explore the universe of human proteins at neXtProt for CDK15: NX_Q96Q40

Explore proteomics data for CDK15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK15 (Q96Q40) (see all 8)
     LADFGLA  VVTLWYR  LKHANIV  DFGLARA 


    See CDK15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001248364.1  NP_001248365.1  NP_631897.1  

    ENSEMBL proteins: 
     ENSP00000389831   ENSP00000386901   ENSP00000260967   ENSP00000406472   ENSP00000412775  
     ENSP00000363726  

    CDK15 Human Recombinant Protein Products:

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    Novus Biologicals CDK15 Proteins
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    Cloud-Clone Corp. CLIAs for CDK15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 15
    TAIRE subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q96Q40

    ProtoNet protein and cluster: Q96Q40

    1 Blocks protein domain: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: CDK15_HUMAN, Q96Q40
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK15_HUMAN, Q96Q40
    Function: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is
    controlled by an associated cyclin (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    CDK15 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDK15:
     Increased cell death in breast  Increased mitotic index 

         1 MGI phenotypic allele for Cdk15 (no phenotypes)

    CDK15 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK15

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDK15

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK15

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK15
    Interactions:

        Search GeneGlobe Interaction Network for CDK15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK15 (Q96Q401, 2, 3 ENSP000002609674) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2P249413, ENSP000002669704I2D: score=2 STRING: ENSP00000266970
    RASSF5Q8WWW03I2D: score=1 
    STK4Q130433I2D: score=1 
    HSP90AB1P082381EBI-1051975,EBI-352572
    CCNCENSP000003582224STRING: ENSP00000358222
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    CDK15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDK15

    1 HMDB Compound for CDK15    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for CDK15    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDK15 gene (3 alternative transcripts): 
    NM_001261435.1  NM_001261436.1  NM_139158.2  

    Unigene Cluster for CDK15:

    Cyclin-dependent kinase 15
    Hs.348711  [show with all ESTs]
    Unigene Representative Sequence: BX647394
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451080(uc010ftm.3) ENST00000410091(uc002uys.2) ENST00000493754
    ENST00000260967(uc010ftn.1) ENST00000488419(uc010fto.1) ENST00000450471(uc002uyt.2)
    ENST00000434439 ENST00000460149 ENST00000466337 ENST00000374598(uc002uyu.1)

    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate CDK15
    SwitchGear 3'UTR luciferase reporter plasmidCDK15 3' UTR sequence
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK15
      QuantiTect SYBR Green Assays in human, mouse, rat CDK15
      QuantiFast Probe-based Assays in human, mouse, rat CDK15

    Additional mRNA sequence: 

    AB053308.1 AK091710.1 AK131512.1 AK292434.1 AK310050.1 BC038807.1 BX647394.1 

    7 DOTS entries:

    DT.100657408  DT.101967618  DT.308931  DT.95110803  DT.102836181  DT.40301046  DT.91657820 

    Selected AceView cDNA sequences (see all 41):

    AA759053 AA405329 AA436054 AI276750 BX095314 AK131512 AB053308 NM_139158 
    AX772791 BC038807 BQ694852 AA405146 AI028242 AA435956 BX283916 CD636738 
    AK091710 BI755983 BE672851 BE562611 CD636736 W03371 BX647394 CD636751 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CDK15    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
    SP1:        -     -                                                     -           -                 -                                 
    SP2:                                                                    -           -                 -     -                           
    SP3:                                                                    -           -                                                   
    SP4:                                            -                       -                                                               
    SP5:                                                                                -     -           -                                 


    ECgene alternative splicing isoforms for CDK15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDK15 Expression
    About this image


    CDK15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Blood (Hematopoietic System)
             Umbilical cord blood-derived mesenchymal stem cells
    CDK15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.348711
        Custom PCR Arrays for CDK15
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK15 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk151 , 5 cyclin-dependent kinase 151, 5 89.12(n)1
    90.61(a)1
      1 (29.47 cM)5
    2716971  NM_001033373.21  NP_001028545.21 
     592569065 
    chicken
    (Gallus gallus)
    Aves CDK151 cyclin-dependent kinase 15 71.81(n)
    69.41(a)
      424086  XM_004942625.1  XP_004942682.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK156
    cyclin-dependent kinase 15
    67(a)
    1 ↔ 1
    GL343478.1(31546-65328)
    zebrafish
    (Danio rerio)
    Actinopterygii cdk151 cyclin-dependent kinase 15 65.95(n)
    67.11(a)
      791619  NM_001040308.1  NP_001035398.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eip63E6
    Ecdysone-induced protein 63E
    42(a)
    1 → many
    3L(3515751-3610521)
    worm
    (Caenorhabditis elegans)
    Secernentea ZC123.46
    Protein ZC123.4, isoform b
    30(a)
    1 → many
    I(841746-846763) WBGene00022519
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO856
    Cyclin-dependent kinase, with ten cyclin partners;...
    48(a)
    1 → many
    XVI(492018-493037) YPL031C


    ENSEMBL Gene Tree for CDK15 (if available)
    TreeFam Gene Tree for CDK15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK15 gene
    CDK182  CDK142  CDK162  CDK52  CDK172  
    Selected SIMAP similar genes for CDK15 using alignment to 2 protein entries:     CDK15_HUMAN (see all proteins) (see all similar genes):
    CDK14    PCTK3    CDK16    PCTK1    CDK18    CDK5
    CDK3    CDK17    CDK1    CDC2    DKFZp686L20222    CDK7
    CDK4    CDK10    CDK2    CDK20    CDK6    MAK

    CDK15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK15 (see all 1777)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0420204
    A breast infiltrating ductal carcinoma sample4--see VAR_0420202 E D mis40--------
    VAR_0420174
    A renal clear cell carcinoma sample4--see VAR_0420172 K E mis40--------
    rs2000429621,2
    C--202669203(+) CGGAAA/GAAAAA 1 -- us2k10--------
    rs1932006031,2
    --202669221(+) AAGTAG/TTTAAT 1 -- us2k10--------
    rs794908311,2
    --202669325(+) AGGAGG/TATCGC 3 -- us2k10--------
    rs1851711451,2
    --202669410(+) CCAGGC/TATGGT 3 -- us2k10--------
    rs1884891871,2
    --202669418(+) GGTGGC/TGTGCA 3 -- us2k10--------
    rs1455655131,2
    C--202669495(+) GCCTA-/GGCAAC 3 -- us2k10--------
    rs1142272941,2
    C,F--202669598(+) ACTGAG/ACCCAG 3 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1927330211,2
    --202669824(+) TCAAAG/TGGAAT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK15 (202655184 - 202760273 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CDK15 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2767CNV Deletion18987735
    esv2585128CNV Deletion19546169
    esv2616659CNV Deletion19546169
    esv1175048CNV Deletion17803354
    esv993740CNV Deletion20482838
    esv2033442CNV Deletion18987734
    esv996523CNV Deletion20482838
    esv2721367CNV Deletion23290073
    nsv834511CNV Loss17160897
    esv9186CNV Loss19470904

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for CDK15:    
    About MalaCards
    amyotrophic lateral sclerosis 2, juvenile    lateral sclerosis    amyotrophic lateral sclerosis


    CDK15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDK15

    Export disorders for CDK15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK15 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with CDK15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PubMed id 11586298)1, 2, 3 Hadano S....Ikeda J.-E. (Nat. Genet. 2001)
    2. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (Nat. Cell Biol. 2009)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. Mammalian cyclin-dependent kinases. (PubMed id 16236519)1, 3 Malumbres M. and Barbacid M. (Trends Biochem. Sci. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (Science 2002)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65061 HGNC: 14434 AceView: ALS2CR7 Ensembl:ENSG00000138395 euGenes: HUgn65061
    ECgene: CDK15 H-InvDB: CDK15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDK15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK15 gene:
    Search GeneIP for patents involving CDK15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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