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Aliases for CDK15 Gene

Aliases for CDK15 Gene

  • Cyclin Dependent Kinase 15 2 3 5
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 7 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 7 2 3
  • Serine/Threonine-Protein Kinase PFTAIRE-2 3 4
  • Serine/Threonine-Protein Kinase ALS2CR7 3 4
  • Cell Division Protein Kinase 15 3 4
  • PFTAIRE Protein Kinase 2 2 3
  • EC 2.7.11.22 4 61
  • ALS2CR7 3 4
  • PFTK2 3 4
  • Serine/Threonine Protein Kinase 3
  • Cyclin-Dependent Kinase 15 3
  • EC 2.7.11 61
  • PFTAIRE2 3

External Ids for CDK15 Gene

Previous HGNC Symbols for CDK15 Gene

  • ALS2CR7
  • PFTK2

Previous GeneCards Identifiers for CDK15 Gene

  • GC02P202382
  • GC02P202656
  • GC02P194519

Summaries for CDK15 Gene

GeneCards Summary for CDK15 Gene

CDK15 (Cyclin Dependent Kinase 15) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK14.

UniProtKB/Swiss-Prot for CDK15 Gene

  • Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at Thr-34.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK15 Gene

Genomics for CDK15 Gene

Regulatory Elements for CDK15 Gene

Enhancers for CDK15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F202178 0.5 ENCODE 11.4 +388.1 388054 0.2 CTCF ZNF654 TEAD1 TRIM22 REST RAD21 ZNF101 ZNF143 SMC3 PRDM1 FZD7 CDK15 LOC729224 KIAA2012 NOP58 ENSG00000212309 SNORD70 RNU6-440P PSMA2P3
GH02F201830 0.5 ENCODE 10.9 +41.1 41105 1.1 CDK15 RNU6-440P KIAA2012 GC02P201825 GC02P201846
GH02F202030 0.9 FANTOM5 Ensembl ENCODE 10.8 +244.7 244735 9.8 ATF1 ZNF133 SIN3A ZNF48 ZNF2 GLIS2 ZNF143 ZNF207 FOS ZNF202 FZD7 NOP58 KIAA2012 CDK15 LOC729224 RNU6-440P FAM117B TMEM237
GH02F202161 0.6 Ensembl 10.7 +370.6 370642 0.2 IKZF1 LOC729224 CDK15 FZD7 PSMA2P3
GH02F202162 0.4 FANTOM5 10.7 +371.2 371216 0.1 PKNOX1 JUND ZBTB48 PBX2 SIN3A EBF1 TBX21 LOC729224 CDK15 FZD7 ALS2 PSMA2P3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CDK15 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDK15 Gene

Chromosome:
2
Start:
201,790,459 bp from pter
End:
201,895,550 bp from pter
Size:
105,092 bases
Orientation:
Plus strand

Genomic View for CDK15 Gene

Genes around CDK15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK15 Gene

Proteins for CDK15 Gene

  • Protein details for CDK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96Q40-CDK15_HUMAN
    Recommended name:
    Cyclin-dependent kinase 15
    Protein Accession:
    Q96Q40
    Secondary Accessions:
    • A8K8R9
    • B8ZZX0
    • C9J1N8
    • C9K003
    • F8W6H8
    • Q4ZG86
    • Q53TV1
    • Q6ZMR9
    • Q8IUP1

    Protein attributes for CDK15 Gene

    Size:
    435 amino acids
    Molecular mass:
    49023 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18656.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK15 Gene

Selected DME Specific Peptides for CDK15 Gene

Q96Q40:
  • LEKLGEG
  • GELKLADFGLA
  • DFGLARA
  • LKHANIV
  • VVTLWYR
  • LADFGLA
  • VLHRDLK
  • HRDLKPQN

Post-translational modifications for CDK15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CDK15 Gene

Gene Families for CDK15 Gene

Protein Domains for CDK15 Gene

Suggested Antigen Peptide Sequences for CDK15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96Q40

UniProtKB/Swiss-Prot:

CDK15_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK15: view

Function for CDK15 Gene

Molecular function for CDK15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at Thr-34.

Enzyme Numbers (IUBMB) for CDK15 Gene

Gene Ontology (GO) - Molecular Function for CDK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 24866247
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 22939624
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK15: view
genes like me logo Genes that share phenotypes with CDK15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK15

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK15 Gene

Localization for CDK15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK15 Gene COMPARTMENTS Subcellular localization image for CDK15 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDK15 Gene

Pathways & Interactions for CDK15 Gene

SuperPathways for CDK15 Gene

No Data Available

Pathways by source for CDK15 Gene

1 GeneTex pathway for CDK15 Gene

Gene Ontology (GO) - Biological Process for CDK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDK15: view

No data available for SIGNOR curated interactions for CDK15 Gene

Drugs & Compounds for CDK15 Gene

(2) Drugs for CDK15 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra Target 0
Magnesium Nutra 0
genes like me logo Genes that share compounds with CDK15: view

Transcripts for CDK15 Gene

Unigene Clusters for CDK15 Gene

Cyclin-dependent kinase 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK15 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for CDK15 Gene

GeneLoc Exon Structure for
CDK15
ECgene alternative splicing isoforms for
CDK15

Expression for CDK15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK15 Gene

mRNA differential expression in normal tissues according to GTEx for CDK15 Gene

This gene is overexpressed in Ovary (x8.8).

Protein differential expression in normal tissues from HIPED for CDK15 Gene

This gene is overexpressed in Heart (35.9) and Brain (33.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDK15 Gene



Protein tissue co-expression partners for CDK15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK15 Gene:

CDK15

SOURCE GeneReport for Unigene cluster for CDK15 Gene:

Hs.348711
genes like me logo Genes that share expression patterns with CDK15: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CDK15 Gene

Orthologs for CDK15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK15 34 35
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia CDK15 34 35
  • 93.08 (n)
cow
(Bos Taurus)
Mammalia CDK15 34
  • 90.19 (n)
mouse
(Mus musculus)
Mammalia Cdk15 34 16 35
  • 89.12 (n)
oppossum
(Monodelphis domestica)
Mammalia CDK15 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fzd7 34
  • 84.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDK15 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK15 34 35
  • 71.81 (n)
lizard
(Anolis carolinensis)
Reptilia CDK15 35
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cdk15 34 35
  • 65.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta Eip63E 35
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC123.4 35
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 35
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10643 35
  • 54 (a)
OneToMany
Species where no ortholog for CDK15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CDK15 Gene

ENSEMBL:
Gene Tree for CDK15 (if available)
TreeFam:
Gene Tree for CDK15 (if available)

Paralogs for CDK15 Gene

Paralogs for CDK15 Gene

genes like me logo Genes that share paralogs with CDK15: view

Variants for CDK15 Gene

Sequence variations from dbSNP and Humsavar for CDK15 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_042017 A renal clear cell carcinoma sample
VAR_042020 A breast infiltrating ductal carcinoma sample
rs10168079 -- 201,791,201(+) CTATT(C/T)GATGA intron-variant
rs10169314 -- 201,866,958(+) GGGGC(A/G)TCAGC intron-variant
rs10171801 -- 201,850,455(+) TAGGT(A/T)CTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK15 Gene

Variant ID Type Subtype PubMed ID
dgv2130n106 CNV deletion 24896259
dgv7250n54 CNV loss 21841781
dgv7251n54 CNV loss 21841781
esv1004233 CNV loss 20482838
esv1007353 CNV loss 20482838
esv1175048 CNV deletion 17803354
esv2033442 CNV deletion 18987734
esv22656 CNV loss 19812545
esv23406 CNV gain 19812545
esv2585128 CNV deletion 19546169
esv2616659 CNV deletion 19546169
esv2721367 CNV deletion 23290073
esv2767 CNV loss 18987735
esv2839458 CNV deletion 24192839
esv2839569 CNV deletion 24192839
esv2862124 CNV duplication 24192839
esv3560825 CNV deletion 23714750
esv3593987 CNV gain 21293372
esv3593989 CNV loss 21293372
esv9186 CNV loss 19470904
esv992519 CNV gain 20482838
esv993740 CNV deletion 20482838
esv996523 CNV deletion 20482838
nsv1073005 CNV deletion 25765185
nsv1148158 CNV deletion 26484159
nsv215499 CNV deletion 16902084
nsv524548 CNV gain 19592680
nsv527313 CNV loss 19592680
nsv834511 CNV loss 17160897
nsv979165 CNV duplication 23825009

Variation tolerance for CDK15 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK15 Gene

Disorders for CDK15 Gene

Relevant External Links for CDK15

Genetic Association Database (GAD)
CDK15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK15

No disorders were found for CDK15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK15 Gene

Publications for CDK15 Gene

  1. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PMID: 11586298) Hadano S. … Ikeda J.-E. (Nat. Genet. 2001) 2 3 4 64
  2. ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34. (PMID: 24866247) Park M.H. … Chung Y.H. (Biochem. Biophys. Res. Commun. 2014) 3 4 64
  3. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3 64
  4. Mammalian cyclin-dependent kinases. (PMID: 16236519) Malumbres M. … Barbacid M. (Trends Biochem. Sci. 2005) 2 3 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64

Products for CDK15 Gene

Sources for CDK15 Gene

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