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Aliases for CDK15 Gene

Aliases for CDK15 Gene

  • Cyclin-Dependent Kinase 15 2 3 5
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 7 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 7 2 3
  • Serine/Threonine-Protein Kinase PFTAIRE-2 3 4
  • Serine/Threonine-Protein Kinase ALS2CR7 3 4
  • Cell Division Protein Kinase 15 3 4
  • PFTAIRE Protein Kinase 2 2 3
  • EC 2.7.11.22 4 63
  • ALS2CR7 3 4
  • PFTK2 3 4
  • Serine/Threonine Protein Kinase 3
  • EC 2.7.11 63
  • PFTAIRE2 3

External Ids for CDK15 Gene

Previous HGNC Symbols for CDK15 Gene

  • ALS2CR7
  • PFTK2

Previous GeneCards Identifiers for CDK15 Gene

  • GC02P202382
  • GC02P202656
  • GC02P194519

Summaries for CDK15 Gene

GeneCards Summary for CDK15 Gene

CDK15 (Cyclin-Dependent Kinase 15) is a Protein Coding gene. Diseases associated with CDK15 include Amyotrophic Lateral Sclerosis 2, Juvenile. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK14.

UniProtKB/Swiss-Prot for CDK15 Gene

  • Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at Thr-34.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK15 Gene

Genomics for CDK15 Gene

Regulatory Elements for CDK15 Gene

Enhancers for CDK15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDK15 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDK15 Gene

Chromosome:
2
Start:
201,790,459 bp from pter
End:
201,895,550 bp from pter
Size:
105,092 bases
Orientation:
Plus strand

Genomic View for CDK15 Gene

Genes around CDK15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK15 Gene

Proteins for CDK15 Gene

  • Protein details for CDK15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96Q40-CDK15_HUMAN
    Recommended name:
    Cyclin-dependent kinase 15
    Protein Accession:
    Q96Q40
    Secondary Accessions:
    • A8K8R9
    • B8ZZX0
    • C9J1N8
    • C9K003
    • F8W6H8
    • Q4ZG86
    • Q53TV1
    • Q6ZMR9
    • Q8IUP1

    Protein attributes for CDK15 Gene

    Size:
    435 amino acids
    Molecular mass:
    49023 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18656.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK15 Gene

Proteomics data for CDK15 Gene at MOPED

Selected DME Specific Peptides for CDK15 Gene

Post-translational modifications for CDK15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK15 Gene

Antibody Products

  • Abcam antibodies for AL2S7

Domains & Families for CDK15 Gene

Gene Families for CDK15 Gene

Suggested Antigen Peptide Sequences for CDK15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96Q40

UniProtKB/Swiss-Prot:

CDK15_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK15: view

Function for CDK15 Gene

Molecular function for CDK15 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at Thr-34.

Enzyme Numbers (IUBMB) for CDK15 Gene

Gene Ontology (GO) - Molecular Function for CDK15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IDA 24866247
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK15: view
genes like me logo Genes that share phenotypes with CDK15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK15

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK15 Gene

Localization for CDK15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK15 Gene COMPARTMENTS Subcellular localization image for CDK15 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDK15 Gene

Pathways & Interactions for CDK15 Gene

SuperPathways for CDK15 Gene

No Data Available

Pathways by source for CDK15 Gene

1 GeneTex pathway for CDK15 Gene

Gene Ontology (GO) - Biological Process for CDK15 Gene

None

No data available for SIGNOR curated interactions for CDK15 Gene

Drugs & Compounds for CDK15 Gene

(2) Drugs for CDK15 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra Target 0
Magnesium Nutra 0
genes like me logo Genes that share compounds with CDK15: view

Transcripts for CDK15 Gene

Unigene Clusters for CDK15 Gene

Cyclin-dependent kinase 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK15 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for CDK15 Gene

GeneLoc Exon Structure for
CDK15
ECgene alternative splicing isoforms for
CDK15

Expression for CDK15 Gene

mRNA expression in normal human tissues for CDK15 Gene

mRNA differential expression in normal tissues according to GTEx for CDK15 Gene

This gene is overexpressed in Ovary (x8.8).

Protein differential expression in normal tissues from HIPED for CDK15 Gene

This gene is overexpressed in Heart (35.9) and Brain (33.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDK15 Gene



SOURCE GeneReport for Unigene cluster for CDK15 Gene Hs.348711

genes like me logo Genes that share expression patterns with CDK15: view

Protein tissue co-expression partners for CDK15 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CDK15 Gene

Orthologs for CDK15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDK15 35
  • 90.19 (n)
  • 90.65 (a)
dog
(Canis familiaris)
Mammalia CDK15 35
  • 93.08 (n)
  • 92.54 (a)
CDK15 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk15 35
  • 89.12 (n)
  • 90.61 (a)
Cdk15 16
Cdk15 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDK15 35
  • 99.15 (n)
  • 98.83 (a)
CDK15 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fzd7 35
  • 84.23 (n)
  • 85.78 (a)
oppossum
(Monodelphis domestica)
Mammalia CDK15 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK15 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK15 35
  • 71.81 (n)
  • 69.41 (a)
CDK15 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK15 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cdk15 35
  • 65.95 (n)
  • 67.11 (a)
cdk15 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Eip63E 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC123.4 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 36
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10643 36
  • 54 (a)
OneToMany
Species with no ortholog for CDK15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CDK15 Gene

ENSEMBL:
Gene Tree for CDK15 (if available)
TreeFam:
Gene Tree for CDK15 (if available)

Paralogs for CDK15 Gene

Paralogs for CDK15 Gene

genes like me logo Genes that share paralogs with CDK15: view

Variants for CDK15 Gene

Sequence variations from dbSNP and Humsavar for CDK15 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs34776344 - 201,807,560(+) CTGCC(C/G/T)GTGCC nc-transcript-variant, reference, missense
VAR_042017 A renal clear cell carcinoma sample
rs56135556 - 201,812,494(+) TGGAC(A/G)ACTAG nc-transcript-variant, reference, missense
rs34851370 - 201,835,676(+) CCAGA(A/C/T)ATACT nc-transcript-variant, reference, missense
VAR_042020 A breast infiltrating ductal carcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for CDK15 Gene

Variant ID Type Subtype PubMed ID
nsv524548 CNV Gain 19592680
nsv875710 CNV Gain 21882294
nsv834511 CNV Loss 17160897
nsv527313 CNV Loss 19592680
esv2616659 CNV Deletion 19546169
esv2033442 CNV Deletion 18987734
esv2767 CNV Deletion 18987735
esv2721367 CNV Deletion 23290073
nsv215499 CNV Loss 16902084
esv996523 CNV Deletion 20482838
esv9186 CNV Loss 19470904
esv2585128 CNV Deletion 19546169
esv1175048 CNV Deletion 17803354
esv993740 CNV Deletion 20482838
esv1004233 CNV Loss 20482838
esv1007353 CNV Loss 20482838
esv22656 CNV Loss 19812545
esv992519 CNV Gain 20482838
esv23406 CNV Gain 19812545

Variation tolerance for CDK15 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDK15 Gene

Disorders for CDK15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK15 Gene - From: GeneCards

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 2, juvenile
  • als2
- elite association - COSMIC cancer census association via MalaCards
Search CDK15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDK15

Genetic Association Database (GAD)
CDK15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK15
genes like me logo Genes that share disorders with CDK15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK15 Gene

Publications for CDK15 Gene

  1. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PMID: 11586298) Hadano S. … Ikeda J.-E. (Nat. Genet. 2001) 2 3 4 67
  2. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3
  3. Mammalian cyclin-dependent kinases. (PMID: 16236519) Malumbres M. … Barbacid M. (Trends Biochem. Sci. 2005) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34. (PMID: 24866247) Park M.H. … Chung Y.H. (Biochem. Biophys. Res. Commun. 2014) 3

Products for CDK15 Gene

Sources for CDK15 Gene

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