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Aliases for CDK14 Gene

Aliases for CDK14 Gene

  • Cyclin Dependent Kinase 14 2 3 5
  • Serine/Threonine-Protein Kinase PFTAIRE-1 3 4
  • Cell Division Protein Kinase 14 3 4
  • PFTAIRE Protein Kinase 1 2 3
  • EC 2.7.11.22 4 61
  • PFTK1 3 4
  • Cyclin-Dependent Kinase 14 3
  • HPFTAIRE1 4
  • EC 2.7.11 61
  • PFTAIRE1 3
  • KIAA0834 4

External Ids for CDK14 Gene

Previous HGNC Symbols for CDK14 Gene

  • PFTK1

Previous GeneCards Identifiers for CDK14 Gene

  • GC07P090095
  • GC07P084947
  • GC07P090468

Summaries for CDK14 Gene

Entrez Gene Summary for CDK14 Gene

  • PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CDK14 Gene

CDK14 (Cyclin Dependent Kinase 14) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK15.

UniProtKB/Swiss-Prot for CDK14 Gene

  • Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at Ser-1490, leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

Gene Wiki entry for CDK14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK14 Gene

Genomics for CDK14 Gene

Regulatory Elements for CDK14 Gene

Enhancers for CDK14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G090623 1.3 FANTOM5 Ensembl ENCODE 12.4 +158.8 158815 3.2 ZNF146 JUN TEAD4 CEBPB E2F4 EP300 ATF2 RAD21 JUND POLR2A ENSG00000223969 CDK14 ENSG00000251154 CLDN12 GTPBP10 TVP23CP1 GC07P090613
GH07G090621 1.3 FANTOM5 Ensembl ENCODE 11.8 +155.2 155178 1.2 CHD7 ZNF366 EED IKZF1 STAT3 POU5F1 FOXJ2 ETV6 RELB FOXP2 ENSG00000223969 CDK14 STEAP2 GC07P090613 TVP23CP1
GH07G090629 0.6 ENCODE 12.4 +163.1 163088 0.1 CTCF ZNF654 ZNF143 SMC3 RAD21 DEK RFX5 ENSG00000223969 CDK14 ENSG00000251154 CLDN12 TVP23CP1 GC07P090613
GH07G090766 1.2 Ensembl ENCODE 4.3 +300.8 300773 2.2 HNRNPUL1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 JUNB PPARG KAT8 ENSG00000223969 STEAP2 GTPBP10 CDK14 GC07P090827 GC07P090678 GC07P090677
GH07G090816 1.2 Ensembl ENCODE 4.1 +351.0 350952 2.3 PKNOX1 SIN3A FEZF1 YY1 GATA2 CBX5 ZNF207 FOS JUNB TSHZ1 GTPBP10 CDK14 GC07P090827 GC07P090678 GC07P090677
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDK14 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDK14 Gene

Chromosome:
7
Start:
90,466,424 bp from pter
End:
91,210,590 bp from pter
Size:
744,167 bases
Orientation:
Plus strand

Genomic View for CDK14 Gene

Genes around CDK14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK14 Gene

Proteins for CDK14 Gene

  • Protein details for CDK14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94921-CDK14_HUMAN
    Recommended name:
    Cyclin-dependent kinase 14
    Protein Accession:
    O94921
    Secondary Accessions:
    • A4D1E6
    • A6NK51
    • A8WFP6
    • B4DHG5
    • B4DNM2
    • Q75N06
    • Q75N22
    • Q8N764
    • Q9H3D7
    • Q9UDR0

    Protein attributes for CDK14 Gene

    Size:
    469 amino acids
    Molecular mass:
    53057 Da
    Quaternary structure:
    • Found in a complex with LRP6, CCNY and CAPRIN2 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus (PubMed:27821587). Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6 (PubMed:20059949, PubMed:19524571). Interacts with CCDN3 and CDKN1A (PubMed:17517622). Interacts with SEPT8 (PubMed:12098780). Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ (PubMed:16775625).
    SequenceCaution:
    • Sequence=BAA74857.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK14 Gene

Selected DME Specific Peptides for CDK14 Gene

O94921:
  • ILHRDLK
  • VVTLWYR
  • LADFGLA
  • TYSNEVVTLWYRPPDVLLGSTEYST
  • LEKLGEG
  • HRDLKPQN
  • GELKLADFGLA
  • DFGLARA
  • FLFQLLRGL
  • LKHANIV
  • PDVLLGS
  • NVKLFLFQLLRGL

Post-translational modifications for CDK14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for CDK14

Domains & Families for CDK14 Gene

Gene Families for CDK14 Gene

Protein Domains for CDK14 Gene

Suggested Antigen Peptide Sequences for CDK14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94921

UniProtKB/Swiss-Prot:

CDK14_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK14: view

Function for CDK14 Gene

Molecular function for CDK14 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at Ser-1490, leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

Enzyme Numbers (IUBMB) for CDK14 Gene

Gene Ontology (GO) - Molecular Function for CDK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IMP 19524571
GO:0005515 protein binding IPI 16775625
genes like me logo Genes that share ontologies with CDK14: view
genes like me logo Genes that share phenotypes with CDK14: view

Animal Models for CDK14 Gene

MGI Knock Outs for CDK14:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK14

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDK14

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK14 Gene

Localization for CDK14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK14 Gene

Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK14 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for CDK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA 19524571
GO:0005634 nucleus IDA,TAS --
GO:0005737 cytoplasm TAS 9202329
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA,IEA 19524571
genes like me logo Genes that share ontologies with CDK14: view

Pathways & Interactions for CDK14 Gene

genes like me logo Genes that share pathways with CDK14: view

Pathways by source for CDK14 Gene

1 GeneTex pathway for CDK14 Gene
1 KEGG pathway for CDK14 Gene

SIGNOR curated interactions for CDK14 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CDK14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 20059949
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CDK14: view

Drugs & Compounds for CDK14 Gene

(1) Drugs for CDK14 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for CDK14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK14: view

Transcripts for CDK14 Gene

Unigene Clusters for CDK14 Gene

Cyclin-dependent kinase 14:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDK14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK14 Gene

No ASD Table

Relevant External Links for CDK14 Gene

GeneLoc Exon Structure for
CDK14
ECgene alternative splicing isoforms for
CDK14

Expression for CDK14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK14 Gene

mRNA differential expression in normal tissues according to GTEx for CDK14 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.5).

Protein differential expression in normal tissues from HIPED for CDK14 Gene

This gene is overexpressed in Frontal cortex (44.6) and Retina (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK14 Gene



Protein tissue co-expression partners for CDK14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK14 Gene:

CDK14

SOURCE GeneReport for Unigene cluster for CDK14 Gene:

Hs.258576

mRNA Expression by UniProt/SwissProt for CDK14 Gene:

O94921-CDK14_HUMAN
Tissue specificity: Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected.

Evidence on tissue expression from TISSUES for CDK14 Gene

  • Nervous system(4.9)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with CDK14: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK14 Gene

Orthologs for CDK14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK14 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia CDK14 34 35
  • 96.5 (n)
cow
(Bos Taurus)
Mammalia CDK14 34
  • 94.53 (n)
mouse
(Mus musculus)
Mammalia Cdk14 34 16 35
  • 91.61 (n)
rat
(Rattus norvegicus)
Mammalia Cdk14 34
  • 91.39 (n)
oppossum
(Monodelphis domestica)
Mammalia CDK14 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK14 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK14 34 35
  • 87.93 (n)
lizard
(Anolis carolinensis)
Reptilia CDK14 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk14 34
  • 82.66 (n)
zebrafish
(Danio rerio)
Actinopterygii CDK14 35
  • 90 (a)
OneToOne
zgc:172096 34
  • 78.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta Eip63E 34 35
  • 60.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005729 34
  • 59.55 (n)
worm
(Caenorhabditis elegans)
Secernentea ZC123.4 34 35
  • 56.31 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO85 35
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10643 35
  • 56 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2431 34
Species where no ortholog for CDK14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK14 Gene

ENSEMBL:
Gene Tree for CDK14 (if available)
TreeFam:
Gene Tree for CDK14 (if available)

Paralogs for CDK14 Gene

Variants for CDK14 Gene

Sequence variations from dbSNP and Humsavar for CDK14 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs773301216 An ovarian mucinous carcinoma 91,118,066(+) ACAGT(A/G)TCTTC reference, missense
rs1000000124 -- 90,808,588(+) ATCAT(A/C)ATGAC intron-variant
rs1000002381 -- 91,010,553(+) ATTAC(C/T)AGTAT intron-variant
rs1000005396 -- 91,190,235(+) CTTCC(C/T)CAGTC intron-variant
rs1000009321 -- 90,896,895(+) CTTTG(C/T)CTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK14 Gene

Variant ID Type Subtype PubMed ID
dgv11499n54 CNV gain 21841781
dgv11500n54 CNV loss 21841781
dgv3614n106 CNV deletion 24896259
dgv827n27 CNV gain 19166990
esv1647013 CNV deletion 17803354
esv2017217 CNV deletion 18987734
esv24639 CNV loss 19812545
esv2523347 CNV deletion 19546169
esv26448 CNV loss 19812545
esv2657077 CNV deletion 23128226
esv2675428 CNV deletion 23128226
esv2734811 CNV deletion 23290073
esv2967 CNV loss 18987735
esv32913 CNV loss 17666407
esv3303943 CNV mobile element insertion 20981092
esv3371542 CNV insertion 20981092
esv33717 CNV gain 17666407
esv3542072 CNV deletion 23714750
esv3542074 CNV deletion 23714750
esv3571977 CNV loss 25503493
esv3571978 CNV loss 25503493
esv3614110 CNV loss 21293372
esv3614111 CNV loss 21293372
esv3614112 CNV loss 21293372
esv3614113 CNV loss 21293372
esv3614115 CNV loss 21293372
esv3614116 CNV loss 21293372
esv3614117 CNV loss 21293372
esv3891163 CNV loss 25118596
esv996268 CNV insertion 20482838
esv998831 CNV deletion 20482838
nsv1020637 CNV loss 25217958
nsv1028455 CNV loss 25217958
nsv1033533 CNV loss 25217958
nsv1075981 CNV deletion 25765185
nsv1139904 CNV duplication 24896259
nsv1145152 CNV deletion 24896259
nsv1151619 CNV insertion 26484159
nsv1152975 CNV deletion 26484159
nsv464640 CNV loss 19166990
nsv470379 CNV loss 18288195
nsv477631 CNV novel sequence insertion 20440878
nsv478332 CNV novel sequence insertion 20440878
nsv510098 OTHER sequence alteration 20534489
nsv510099 OTHER sequence alteration 20534489
nsv515998 CNV gain 19592680
nsv517959 CNV loss 19592680
nsv524316 CNV loss 19592680
nsv527216 CNV gain 19592680
nsv528932 CNV loss 19592680
nsv5832 CNV insertion 18451855
nsv5833 CNV insertion 18451855
nsv607795 CNV loss 21841781
nsv607796 CNV loss 21841781
nsv607797 CNV loss 21841781
nsv607798 CNV loss 21841781
nsv607799 CNV loss 21841781
nsv824208 CNV gain 20364138
nsv955973 CNV deletion 24416366

Variation tolerance for CDK14 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK14 Gene

Disorders for CDK14 Gene

Relevant External Links for CDK14

Genetic Association Database (GAD)
CDK14
Human Genome Epidemiology (HuGE) Navigator
CDK14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK14

No disorders were found for CDK14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDK14 Gene

Publications for CDK14 Gene

  1. Identification and cellular localization of human PFTAIRE1. (PMID: 11313143) Yang T. … Chen J.-Y. (Gene 2001) 2 3 4 64
  2. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3 64
  3. Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. (PMID: 19524571) Jiang M. … Chen J. (FEBS Lett. 2009) 3 4 64
  4. Cell cycle control of wnt receptor activation. (PMID: 20059949) Davidson G. … Niehrs C. (Dev. Cell 2009) 3 4 64
  5. Functional characterization of human PFTK1 as a cyclin-dependent kinase. (PMID: 17517622) Shu F. … Wu J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 64

Products for CDK14 Gene

Sources for CDK14 Gene

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