Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK14 Gene

protein-coding   GIFtS: 56
GCID: GC07P090095

cyclin-dependent kinase 14

(Previous name: PFTAIRE protein kinase 1 )
(Previous symbol: PFTK1)
 Explore 6 diseases affiliated with
CDK14 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDK14    

Aliases
for CDK14 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase 141 2     Serine/Threonine-Protein Kinase PFTAIRE-12 3
PFTK11 2 3 5     HPFTAIRE11
PFTAIRE11 2 5     EC 2.7.11.223 8
PFTAIRE Protein Kinase 11 2     KIAA08343 5
Cell Division Protein Kinase 142 3     EC 2.7.118

External Ids:    HGNC: 88831   Entrez Gene: 52182   Ensembl: ENSG000000580917   OMIM: 6106795   UniProtKB: O949213   

Export aliases for CDK14 gene to outside databases

Previous GC identifer: GC07P084947


Summaries
for CDK14 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDK14:
PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 (PubMed
11313143)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: CDK14_HUMAN, O94921
Function: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is
controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by
mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a
regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in
vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron
differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport

Gene Wiki entry for CDK14 (PFTK1)


Genomic Views
for CDK14 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK14
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): CDK14 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22   Ensembl cytogenetic band:  7q21.13   HGNC cytogenetic band: 7q21-q22

CDK14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK14 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P090095:  view genomic region     (about GC identifiers)

Start:
 90,095,738 bp from pter      End:
 90,839,905 bp from pter
Size:
 744,168 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 89,669,510-90,170,369     

Proteins
for CDK14 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDK14_HUMAN, O94921 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 14  
Size: 469 amino acids; 53057 Da
Subunit: Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of
LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and
YWHAQ
Subcellular location: Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell
membrane by CCNY
Sequence caution: Sequence=BAA74857.2; Type=Erroneous initiation;
Secondary accessions: A4D1E6 A6NK51 A8WFP6 B4DHG5 B4DNM2 Q75N06 Q75N22 Q8N764 Q9H3D7 Q9UDR0
Alternative splicing: 3 isoforms:  O94921-1   O94921-2   O94921-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK14: NX_O94921

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O94921

    • 4/12 DME Specific Peptides for CDK14 (O94921) (see all 12)
     LADFGLA  PDVLLGS  LKHANIV  ILHRDLK 

    CDK14 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036527.1  
    ENSEMBL proteins: 
     ENSP00000393616   ENSP00000410770   ENSP00000394570   ENSP00000406848   ENSP00000369390  
     ENSP00000401603   ENSP00000265741   ENSP00000385034   ENSP00000387794   ENSP00000398936  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CDK14
    OriGene Protein Over-expression Lysate: CDK14
    OriGene Custom Protein Services for CDK14 
    GenScript Custom Purified and Recombinant Proteins Services for CDK14
    Novus Biologicals CDK14 Proteins
    Novus Biologicals CDK14 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDK14

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000308cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IDA19524571


    CDK14 for ontologies           About GeneDecksing



    CDK14 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CDK14 
    GenScript Custom Superior Antibodies Services for CDK14
    Novus Biologicals CDK14 Antibodies
    Search for Antibodies for CDK14 at Abcam  
    Uscn Antibodies for CDK14
    ThermoFisher Antibodies for CDK14

    Assay Products for CDK14: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK14
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CDK14

    Protein Domains /
    Families
    for CDK14 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDK14 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O94921

    ProtoNet protein and cluster: O94921

    1 Blocks protein family: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: CDK14_HUMAN, O94921
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CDK14 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDK14_HUMAN, O94921
    Function: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is
    controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by
    mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a
    regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in
    vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron
    differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and
    repressed by CDKN1A

    Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target CDK14:
    hsa-mir-1 (MIRT003763)

    OriGene 3'-UTR Clone: CDK14
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK14
    8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK14 (see all 90):
    hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-549 hsa-miR-3194-5p hsa-miR-3938 hsa-miR-578 hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): CDK14 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK14 (see all 3)
    OriGene siRNA: CDK14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK14

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CDK14

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK14 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK14 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CDK14 (NM_012395)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK14 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CDK14
    Search LifeMap BioReagents cell lines for CDK14

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK14

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein kinase activity IMP--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    CDK14 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for CDK14:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Increased colony dispersion (i 


    Pathways & Interactions
    for CDK14 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for CDK14 (O949211, 2, 3 ENSP000002657414) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNYQ8ND762, 3, ENSP000003638364MINT-7147585 MINT-7147628 MINT-7147743 MINT-7147695 MINT-7147713 MINT-7147647 MINT-7147665 MINT-7147614 MINT-7147598 MINT-7147680 MINT-7147725 I2D: score=3 STRING: ENSP00000363836
    YWHAEP622581, 3, ENSP000002643354EBI-1043945,EBI-356498 I2D: score=3 STRING: ENSP00000264335
    CCND3P302811, 3, ENSP000003620824EBI-1043945,EBI-375013 I2D: score=2 STRING: ENSP00000362082
    YWHABP319461, 3, ENSP000003001614EBI-1043945,EBI-359815 I2D: score=2 STRING: ENSP00000300161
    CDKN1AP389361, 3, ENSP000002447414EBI-1043945,EBI-375077 I2D: score=2 STRING: ENSP00000244741
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IDA--
    GO:0006468protein phosphorylation ----
    GO:0007049cell cycle ----
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0051301cell division IEA--


    CDK14 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK14 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK14
    Search CenterWatch for drugs/clinical trials and news about CDK14 

    Transcripts
    for CDK14 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDK14 gene: 
    NM_012395.2  

    Unigene Cluster for CDK14:

    Cyclin-dependent kinase 14
    Hs.258576  [show with all ESTs]
    Unigene Representative Sequence: BC167152
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449528(uc003ukt.1 uc003ukx.1) ENST00000484035 ENST00000446224(uc003ukv.1)
    ENST00000430760 ENST00000456689(uc003uku.1) ENST00000380050(uc003uky.2)
    ENST00000496279 ENST00000446790 ENST00000265741(uc003ukz.1) ENST00000406263(uc010les.1 uc011khl.1)
    ENST00000431029 ENST00000478540 ENST00000487145 ENST00000460493 ENST00000436577


    miRNA
    Products:             		 OriGene 3'-UTR Clone: CDK14
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK14
    8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK14 (see all 90):
    hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-549 hsa-miR-3194-5p hsa-miR-3938 hsa-miR-578 hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): CDK14 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK14 (see all 3)
    OriGene siRNA: CDK14
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK14
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK14 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK14 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CDK14 (NM_012395)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK14 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK14
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK14
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK14
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK14

    Additional cDNA sequence: 

    AB020641.1 AF119833.1 AK289782.1 AK295086.1 AK296406.1 AK297974.1 AK307484.1 AK316026.1 
    BC136476.1 BC136477.1 BC152388.1 BC152436.1 BC167152.1 BC167156.1 DQ655962.2 DQ655963.2 
    DQ655965.2 DQ655966.2 DQ656060.2 

    9 DOTS entries:

    DT.447754  DT.99979984  DT.92426256  DT.121073664  DT.108133  DT.121073526  DT.121073645  DT.121073691 
    DT.95085341 

    24/103 AceView cDNA sequences (see all 103):

    AA282871 BQ220223 BM740394 BE675209 AL710269 Z40459 NM_012395 AA954361 
    AA342574 BM724492 BX280683 CR595517 BX279872 CB142556 CA429298 BU169665 
    BP347418 CK005197 W20321 BG260591 BM679713 W67113 W67359 AL535374 

    GeneLoc Exon Structure


    Expression
    for CDK14 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATATGGAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDK14 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeRetinaEye
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage

    See CDK14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK14

    SOURCE GeneReport for Unigene cluster: Hs.258576

    UniProtKB/Swiss-Prot: CDK14_HUMAN, O94921
    Tissue specificity: Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels
    in other tissues except in spleen and thymus where expression is barely detected

        SABiosciences Custom PCR Arrays for CDK14
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK14
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK14
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK14
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK14
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK14

    Orthologs
    for CDK14 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK14 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDK141 cyclin-dependent kinase 14 88.28(n)
    97.97(a)    		   420546  XM_418647.3  XP_418647.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CDK146
    		 --
    		 93(a)
    		 1 ↔ 1
    		 6(20558363-20677169)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX740308.12   -- 78.36(n)    BX740308.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1720961 zgc:172096 78.85(n)
    95.35(a)    		   572146  NM_001128260.1  NP_001121732.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Eip63E1 Ecdysone-induced protein 63E 59.13(n)
    66.07(a)    		   38433  NM_001043118.2  NP_001036583.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ZC123.41 Protein ZC123.4 56.06(n)
    56.49(a)    		   171672  NM_058382.3  NP_490783.3 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CDKA16
    CDKB1;26
    (see all 5)    		 cyclin-dependent kinase B1-2
    (see all 5)    		 51(a)
    46(a)
    (see all 5)    		 1 ↔ many
    possible ortholog
    (see all 5)    		 3(18071536-18074641)
    2(16152505-16154086)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 cyclin-dependent kinase A-1, putative, expressed
    (see all 5)    		 46(a)
    45(a)
    (see all 5)    		 possible ortholog
    many ↔ many
    (see all 5)    		 1(38980259-38983035)
    3(996598-1000241)


    ENSEMBL Gene Tree for CDK14 (if available)
    TreeFam Gene Tree for CDK14 (if available) 

    Paralogs
    for CDK14 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK14 gene
    CDK62  CDK182  CDK52  CDK152  CDK42  CDK12  CDK32  CDK162  
    CDK22  CDK172  
    18/46 SIMAP similar genes for CDK14 using alignment to 5 protein entries:     CDK14_HUMAN (see all proteins) (see all similar genes):
    CDK16    CDK15    CDK3    CDK5    CDK1    CDC2
    PCTK1    CDK18    CDK2    MAPK8    DKFZp686L20222    CDK17
    PCTK3    CDK6    CDK7    CDC2L2    CDC2L1    CDK11B

    CDK14 for paralogs           About GeneDecksing



    Genomic Variants
    for CDK14 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8425 NCBI SNPs in CDK14 are shown (see all 8425)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1386778001,2
    		--90336865(+) TTCTAC/TTGGAT 1 -- us2k10--------
    rs1886909381,2
    		--90337049(+) CCAAAA/TGTCCT 1 -- us2k10--------
    rs1811624481,2
    		--90337126(+) CCACCC/TAAGGA 1 -- us2k10--------
    rs790369381,2
    		C,--90337170(+) TACTCA/GTTTCA 1 -- us2k14Minor allele frequency- G:0.16CSA WA NA 241
    rs1492583601,2
    		--90337194(+) ACTTGC/TTTTAT 1 -- us2k10--------
    rs1845919821,2
    		--90337269(+) AGCACA/GTTTGC 1 -- us2k10--------
    rs800690031,2
    		F,--90337331(+) TTTATA/GCAAGA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1892039381,2
    		--90337383(+) GGGGAA/TTGCCT 1 -- us2k10--------
    rs1816409541,2
    		--90337408(+) GCCCTA/GAAATT 1 -- us2k10--------
    rs176234671,2
    		C,F,--90337514(+) ATGCAA/GTTGGC 1 -- us2k13Minor allele frequency- G:0.03NA 138

    HapMap Linkage Disequilibrium report for CDK14 (90095738 - 90345738 bp, first 250kb of CDK14)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 18 variations for CDK14
         12 CNVs: 94683 82081 94680 64885 64886 94682 94677 94681 100027 82080 94684 94679
         6 Indels: 94678 11306 47408 11307 42125 28711

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK14
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK14

    Disorders / Diseases
    for CDK14 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDK14 for disorders           About GeneDecksing

    OMIM gene information: 610679    OMIM disorders: --

    6 diseases for CDK14:    About MalaCards
    autism spectrum disorder    liver cancer    hepatocellular carcinoma    carcinoma
    malaria    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: CDK14 (0 documents)

    Export disorders for CDK14 gene to outside databases

    Publications
    for CDK14 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK14 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with CDK14)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and cellular localization of human PFTAIRE1. (PubMed id 11313143)1, 2, 3 Yang T. and Chen J.-Y. (2001)
    2. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    3. Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. (PubMed id 19524571)1, 2 Jiang M.... Chen J. (2009)
    4. Functional characterization of human PFTK1 as a cyclin-dependent kinase. (PubMed id 17517622)1, 2 Shu F.... Wu J. (2007)
    5. A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins. (PubMed id 16775625)1, 2 Gao Y.... Chen J. (2006)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    8. KIAA0202, a human septin family member, interacting with hPFTAIRE1. (PubMed id 12098780)1, 2 Yang T.... Chen J.Y. (2002)
    9. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    10. A novel cdc2-related protein kinase expressed in the nervous system. (PubMed id 9202329)1, 3 Lazzaro M.A....Julien J.P. (1997)

    External Searches for CDK14 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDK14 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5218 HGNC: 8883 AceView: PFTK1 Ensembl:ENSG00000058091 euGenes: HUgn5218
    ECgene: CDK14 H-InvDB: CDK14

    Other Databases showing CDK14 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0834

    Specialized Databases showing CDK14 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK14 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CDK14 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDK14 gene:
    Search GeneIP for patents involving CDK14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CDK14 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK14   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK14  
     OriGene Protein Over-expression Lysate for CDK14   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CDK14   OriGene 3'-UTR Clone for CDK14  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK14   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK14  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CDK14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDK14   OriGene Custom Protein Services for CDK14  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK14
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK14
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK14
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK14
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK14
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK14
     GenScript Custom Purified and Recombinant Proteins Services for CDK14 GenScript cDNA clones with any tag delivered in your preferred vector for CDK14
     GenScript Custom Assay Services for CDK14 GenScript Custom Superior Antibodies Services for CDK14
     GenScript Custom overexpressing Cell Line Services for CDK14 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for CDK14
     Search Chromatin IP Primers for CDK14
     RT2 qPCR Primer Assay in human, mouse, rat CDK14
     Search GNC Networks for CDK14
     SABiosciences Custom PCR Arrays for CDK14
     Search Tocris compounds for CDK14
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CDK14 antibodies
     CDK14 proteins
     CDK14 lysates
     Search for Antibodies for CDK14 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CDK14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CDK14 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CDK14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK14
     SwitchGear 3'UTR luciferase reporter plasmids for CDK14
     SwitchGear Promoter luciferase reporter plasmids for CDK14
     ThermoFisher Antibodies for CDK14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK14
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CDK14 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4