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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK14 Gene

protein-coding   GIFtS: 62
GCID: GC07P090095

Cyclin-Dependent Kinase 14

(Previous name: PFTAIRE protein kinase 1)
(Previous symbol: PFTK1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 141 2     hPFTAIRE12 3
PFTK11 2 3 5     EC 2.7.11.223 8
PFTAIRE Protein Kinase 11 2     PFTAIRE12 5
Cell Division Protein Kinase 142 3     KIAA08343 5
Serine/Threonine-Protein Kinase PFTAIRE-12 3     EC 2.7.118

External Ids:    HGNC: 88831   Entrez Gene: 52182   Ensembl: ENSG000000580917   OMIM: 6106795   UniProtKB: O949213   

Export aliases for CDK14 gene to outside databases

Previous GC identifer: GC07P084947


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK14 Gene:
PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 (PubMed
11313143)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CDK14 Gene: 
CDK14 (cyclin-dependent kinase 14) is a protein-coding gene. Diseases associated with CDK14 include autism spectrum disorder, and squamous cell carcinoma. GO annotations related to this gene include cyclin binding and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK18.

UniProtKB/Swiss-Prot: CDK14_HUMAN, O94921
Function: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is
controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by
mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts
as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates
RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in
meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose
transport

Gene Wiki entry for CDK14 (PFTK1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK14
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): CDK14 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22   Ensembl cytogenetic band:  7q21.13   HGNC cytogenetic band: 7q21-q22

CDK14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK14 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P090095:  view genomic region     (about GC identifiers)

Start:
90,095,738 bp from pter      End:
90,839,905 bp from pter
Size:
744,168 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 89,669,510-90,170,369     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK14_HUMAN, O94921 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 14  
Size: 469 amino acids; 53057 Da
Subunit: Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of
LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH
and YWHAQ
Subcellular location: Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell
membrane by CCNY
Sequence caution: Sequence=BAA74857.2; Type=Erroneous initiation;
Secondary accessions: A4D1E6 A6NK51 A8WFP6 B4DHG5 B4DNM2 Q75N06 Q75N22 Q8N764 Q9H3D7 Q9UDR0
Alternative splicing: 3 isoforms:  O94921-1   O94921-2   O94921-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK14: NX_O94921

Explore proteomics data for CDK14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94921

  • 4/12 DME Specific Peptides for CDK14 (O94921) (see all 12)
     LADFGLA  PDVLLGS  LKHANIV  ILHRDLK 

    CDK14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK14 Protein Expression
    REFSEQ proteins: NP_036527.1  
    ENSEMBL proteins: 
     ENSP00000393616   ENSP00000410770   ENSP00000394570   ENSP00000406848   ENSP00000369390  
     ENSP00000401603   ENSP00000265741   ENSP00000385034   ENSP00000387794   ENSP00000398936  

    Human Recombinant Protein Products for CDK14: 
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    Novus Biologicals CDK14 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK14 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000308cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA19524571
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IDA19524571

    CDK14 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 14 
    TAIRE subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O94921

    ProtoNet protein and cluster: O94921

    1 Blocks protein domain: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: CDK14_HUMAN, O94921
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK14_HUMAN, O94921
    Function: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is
    controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by
    mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts
    as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates
    RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in
    meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose
    transport
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and
    repressed by CDKN1A

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IMP19524571
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16775625
         
    CDK14 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDK14:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  Increased colony dispersion (i 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK14 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK14 
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    miRNA
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    miRTarBase miRNAs that target CDK14:
    hsa-mir-1 (MIRT003763)

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    8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK14 (see all 90):
    hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-549 hsa-miR-3194-5p hsa-miR-3938 hsa-miR-578 hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): CDK14 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for CDK14):
        Transcriptional misregulation in cancer


    CDK14 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for CDK14 (O949211, 2, 3 ENSP000002657414) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNYQ8ND762, 3, ENSP000003638364MINT-7147585 MINT-7147628 MINT-7147743 MINT-7147695 MINT-7147713 MINT-7147647 MINT-7147665 MINT-7147614 MINT-7147598 MINT-7147680 MINT-7147725 I2D: score=3 STRING: ENSP00000363836
    YWHAEP622581, 3, ENSP000002643354EBI-1043945,EBI-356498 I2D: score=3 STRING: ENSP00000264335
    CCND3P302811, 3, ENSP000003620824EBI-1043945,EBI-375013 I2D: score=2 STRING: ENSP00000362082
    YWHABP319461, 3, ENSP000003001614EBI-1043945,EBI-359815 I2D: score=2 STRING: ENSP00000300161
    CDKN1AP389361, 3, ENSP000002447414EBI-1043945,EBI-375077 I2D: score=2 STRING: ENSP00000244741
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IDA--
    GO:0006468protein phosphorylation ----
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0051301cell division IEA--
    GO:0060828regulation of canonical Wnt receptor signaling pathway IDA--

    CDK14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK14

    Search CenterWatch for drugs/clinical trials and news about CDK14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK14 gene: 
    NM_012395.2  

    Unigene Cluster for CDK14:

    Cyclin-dependent kinase 14
    Hs.258576  [show with all ESTs]
    Unigene Representative Sequence: BC167152
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449528(uc003ukt.1 uc003ukx.1) ENST00000484035 ENST00000446224(uc003ukv.1)
    ENST00000430760 ENST00000456689(uc003uku.1) ENST00000380050(uc003uky.2)
    ENST00000496279 ENST00000446790 ENST00000265741(uc003ukz.1) ENST00000406263(uc010les.1 uc011khl.1)
    ENST00000431029 ENST00000478540 ENST00000487145 ENST00000460493 ENST00000436577

    miRNA
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    hsa-miR-323-3p hsa-miR-3678-3p hsa-miR-549 hsa-miR-3194-5p hsa-miR-3938 hsa-miR-578 hsa-miR-371-5p hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): CDK14 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB020641.1 AF119833.1 AK289782.1 AK295086.1 AK296406.1 AK297974.1 AK307484.1 AK316026.1 
    BC136476.1 BC136477.1 BC152388.1 BC152436.1 BC167152.1 BC167156.1 DQ655962.2 DQ655963.2 
    DQ655965.2 DQ655966.2 DQ656060.2 

    8 DOTS entries:

    DT.447754  DT.99979984  DT.92426256  DT.121073664  DT.108133  DT.121073526  DT.121073645  DT.121073691 

    24/103 AceView cDNA sequences (see all 103):

    Z40459 CA429298 BX280683 BM724492 CR595517 BM740394 AA282871 AL710269 
    BQ220223 BE675209 CB142556 BX279872 AA954361 BU169665 AA342574 NM_012395 
    AI204989 BP360012 BP347418 BP347440 CK005197 AA883846 BQ003954 BX451918 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK14 expression in normal human tissues (normalized intensities)      CDK14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATGGAATA
    CDK14 Expression
    About this image


    CDK14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             brain/forebrain/telencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             spinal/ganglion/dorsal root ganglion   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose   

    See CDK14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK14

    SOURCE GeneReport for Unigene cluster: Hs.258576

    UniProtKB/Swiss-Prot: CDK14_HUMAN, O94921
    Tissue specificity: Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower
    levels in other tissues except in spleen and thymus where expression is barely detected

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK14 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk141 , 5 cyclin-dependent kinase 141, 5 91.38(n)1
    98.37(a)1
      5 (2.61 cM)5
    186471  NM_011074.21  NP_035204.21 
     48033915 
    chicken
    (Gallus gallus)
    Aves CDK141 cyclin-dependent kinase 14 88.28(n)
    97.97(a)
      420546  XM_418647.3  XP_418647.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDK146
    Uncharacterized protein
    88(a)
    1 ↔ 1
    6(20475429-20677169)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX740308.12   -- 78.36(n)    BX740308.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1720961 zgc:172096 78.85(n)
    95.35(a)
      572146  NM_001128260.1  NP_001121732.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Eip63E1 Ecdysone-induced protein 63E 59.13(n)
    66.07(a)
      38433  NM_001043118.2  NP_001036583.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZC123.41 Protein ZC123.4 56.06(n)
    56.49(a)
      171672  NM_058382.3  NP_490783.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO856
    Cyclin-dependent kinase, with ten cyclin partners;...
    50(a)
    1 → many
    XVI(492018-493037)


    ENSEMBL Gene Tree for CDK14 (if available)
    TreeFam Gene Tree for CDK14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK14 gene
    CDK182  CDK62  CDK52  CDK152  CDK12  CDK42  CDK32  CDK162  
    CDK22  CDK172  
    18/45 SIMAP similar genes for CDK14 using alignment to 5 protein entries:     CDK14_HUMAN (see all proteins) (see all similar genes):
    CDK15    CDK16    CDK1    CDK3    CDK5    CDC2
    PCTK1    CDK18    CDK2    MAPK8    DKFZp686L20222    CDK17
    PCTK3    CDK6    CDK7    CDC2L2    CDC2L1    CDK11B

    CDK14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9809 SNPs in CDK14 are shown (see all 9809)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0467654
    An ovarian mucinous carcinoma4--see VAR_0467652 M I mis40--------
    VAR_0467664
    ----see VAR_0467662 S R mis40--------
    rs725294601,2
    C--85375077(+) GGGGG-/GTGTGTG 1 -- int10--------
    rs680509251,2
    C--89675787(+) TTTTT-/T/TT  
            
    CTAGA
    1 -- int12NA 4
    rs677441761,2
    C--89855822(+) TTTTT-/T/TT  
            
    GAGAT
    1 -- int11NA 2
    rs1386778001,2
    --90336865(+) TTCTAC/TTGGAT 1 -- us2k10--------
    rs1886909381,2
    --90337049(+) CCAAAA/TGTCCT 1 -- us2k10--------
    rs1811624481,2
    C--90337126(+) CCACCC/TAAGGA 1 -- us2k10--------
    rs790369381,2
    C,F--90337170(+) TACTCA/GTTTCA 1 -- us2k14Minor allele frequency- G:0.16CSA WA NA 241
    rs1492583601,2
    --90337194(+) ACTTGC/TTTTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK14 (90095738 - 90345738 bp, first 250kb of CDK14)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for CDK14 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1647013CNV Deletion17803354
    esv998831CNV Deletion20482838
    esv2675428CNV Deletion23128226
    esv2967CNV Deletion18987735
    esv2657077CNV Deletion23128226
    esv2523347CNV Deletion19546169
    esv2017217CNV Deletion18987734
    esv2734811CNV Deletion23290073
    nsv5832CNV Insertion18451855
    nsv5833CNV Insertion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610679    OMIM disorders: --

    4 diseases for CDK14:    About MalaCards
    autism spectrum disorder    squamous cell carcinoma    hepatocellular carcinoma    neuronitis


    CDK14 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDK14
    Human Genome Epidemiology (HuGE) Navigator: CDK14 (0 documents)

    Export disorders for CDK14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK14 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with CDK14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and cellular localization of human PFTAIRE1. (PubMed id 11313143)1, 2, 3 Yang T. and Chen J.-Y. (2001)
    2. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    3. Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. (PubMed id 19524571)1, 2 Jiang M.... Chen J. (2009)
    4. Functional characterization of human PFTK1 as a cyclin-dependent kinase. (PubMed id 17517622)1, 2 Shu F.... Wu J. (2007)
    5. A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins. (PubMed id 16775625)1, 2 Gao Y.... Chen J. (2006)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    8. KIAA0202, a human septin family member, interacting with hPFTAIRE1. (PubMed id 12098780)1, 2 Yang T.... Chen J.Y. (2002)
    9. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T....Ohara O. (1998)
    10. A novel cdc2-related protein kinase expressed in the nervous system. (PubMed id 9202329)1, 3 Lazzaro M.A....Julien J.P. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5218 HGNC: 8883 AceView: PFTK1 Ensembl:ENSG00000058091 euGenes: HUgn5218
    ECgene: CDK14 Kegg: 5218 H-InvDB: CDK14

    (According to HUGE)
    About This Section
    HUGE: KIAA0834

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK14 gene:
    Search GeneIP for patents involving CDK14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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