Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK13 Gene

protein-coding   GIFtS: 54
GCID: GC07P039957

cyclin-dependent kinase 13

(Previous name: cell division cycle 2-like 5 (cholinesterase-related cell...)
(Previous symbol: CDC2L5)
 Explore 8 diseases affiliated with
CDK13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDK13    

Aliases
for CDK13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase 131 2     Cholinesterase-Related Cell Division Controller2 3
CDC2L1 2 3     CDC2-Related Protein Kinase 52 3
CDC2L51 2 3     HCDK131
CHED1 2 3     EC 2.7.11.223 8
KIAA17911 3     Cell Division Cycle 2-Like 5 (Cholinesterase-Related Cell Division Controller)1
Cell Division Cycle 2-Like Protein Kinase 52 3     EC 2.7.11.233
Cell Division Protein Kinase 132 3     EC 2.7.118

External Ids:    HGNC: 17331   Entrez Gene: 86212   Ensembl: ENSG000000658837   OMIM: 6033095   UniProtKB: Q140043   

Export aliases for CDK13 gene to outside databases

Previous GC identifer: GC07P039875


Summaries
for CDK13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDK13:
The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of
this family are well known for their essential roles as master switches in cell cycle control. The exact function of
this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation
of hematopoiesis. Alternatively spliced transcript variants have been described.(provided by RefSeq, Dec 2009)

UniProtKB/Swiss-Prot: CDK13_HUMAN, Q14004
Function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase
activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II
subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by
phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1
Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production
of the doubly spliced HIV-1 protein Nef

Gene Wiki entry for CDK13 (CDC2L5)


Genomic Views
for CDK13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK13
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): CDK13 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14.1

CDK13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK13 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P039957:  view genomic region     (about GC identifiers)

Start:
 39,989,636 bp from pter      End:
 40,136,733 bp from pter
Size:
 147,098 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 40,028,472-40,175,171     

Proteins
for CDK13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDK13_HUMAN, Q14004 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 13  
Size: 1512 amino acids; 164923 Da
Subunit: Interacts with CCNL1 and CCNL2 (By similarity). Interacts with C1QBP. Interacts with HIV-1 Tat
Subcellular location: Nucleus speckle
Rna editing: Modified_positions=103; Note=Edited at about 88%
Sequence caution: Sequence=AAA58424.1; Type=Frameshift; Positions=1006; Sequence=AAS07490.1; Type=Erroneous gene model
prediction;
Secondary accessions: Q53G78 Q6DKQ9 Q75MH4 Q75MH5 Q96JN4 Q9H4A0 Q9H4A1 Q9UDR4
Alternative splicing: 2 isoforms:  Q14004-1   Q14004-2   

Explore the universe of human proteins at neXtProt for CDK13: NX_Q14004

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14004

    • 4/16 DME Specific Peptides for CDK13 (Q14004) (see all 16)
     LADFGLA  FLHRDIK  IGEGTYG  NMKEIVTDK 

    CDK13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_003709.3  NP_112557.2  

    ENSEMBL proteins: 
     ENSP00000181839   ENSP00000340557  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CDK13
    OriGene Custom Protein Services for CDK13 
    GenScript Custom Purified and Recombinant Proteins Services for CDK13
    Novus Biologicals CDK13 Proteins
    Novus Biologicals CDK13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDK13

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002945cyclin K-CDK13 complex IPI--
    GO:0016607nuclear speck IDA16721827
    GO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex ISS--


    CDK13 for ontologies           About GeneDecksing



    CDK13 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CDK13 
    GenScript Custom Superior Antibodies Services for CDK13
    Novus Biologicals CDK13 Antibodies
    Search for Antibodies for CDK13 at Abcam  
    Uscn Antibodies for CDK13
    ThermoFisher Antibodies for CDK13

    Assay Products for CDK13: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK13
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CDK13

    Protein Domains /
    Families
    for CDK13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDK13 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q14004

    ProtoNet protein and cluster: Q14004

    UniProtKB/Swiss-Prot: CDK13_HUMAN, Q14004
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CDK13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDK13_HUMAN, Q14004
    Function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase
    activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II
    subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by
    phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1
    Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production
    of the doubly spliced HIV-1 protein Nef
    Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

    Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.11.231 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): CDK13
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK13
    8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK13 (see all 90):
    hsa-miR-100* hsa-miR-607 hsa-miR-4272 hsa-miR-218-1* hsa-miR-200a hsa-miR-938 hsa-miR-219-5p hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmid: CDK13 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK13 (see all 4)
    OriGene shRNA RFP: CDK13
    OriGene siRNA: CDK13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK13

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CDK13

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK13 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK13 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK13 (NM_003718)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK13 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CDK13
    Search LifeMap BioReagents cell lines for CDK13

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK13

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS1731328
    GO:0004693cyclin-dependent protein kinase activity IEA--
    GO:0005515protein binding IPI16721827
    GO:0005524ATP binding IEA--
    GO:0008353RNA polymerase II carboxy-terminal domain kinase activity IDA--


    CDK13 for ontologies           About GeneDecksing


    10 GenomeRNAi human phenotypes for CDK13:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  G0/1 arrest 
     Increased G1 DNA content  Increased mitotic index  Stronger migration  Synthetic lethal with Ras 
     Synthetic lethal with c-Myc af  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Cdk13tm1Lex for CDK13
         1 MGI phenotypic allele for Cdk13 (no phenotypes)

    CDK13 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDK13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/26 Interacting proteins for CDK13 (Q140041, 2, 3 ENSP000001818394) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61855 I2D: score=3 
    ALKQ9UM733, ENSP000003737004I2D: score=1 STRING: ENSP00000373700
    CHMP4AQ9BY433, ENSP000003242054I2D: score=1 STRING: ENSP00000324205
    TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000380alternative mRNA splicing, via spliceosome TAS16721827
    GO:0006468protein phosphorylation ----
    GO:0007088regulation of mitosis TAS1731328
    GO:0007275multicellular organismal development TAS1731328
    GO:0008284positive regulation of cell proliferation TAS1731328


    CDK13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK13

    2 HMDB Compounds for CDK13    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Search CenterWatch for drugs/clinical trials and news about CDK13 

    Transcripts
    for CDK13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDK13 gene (2 alternative transcripts): 
    NM_003718.4  NM_031267.3  

    Unigene Cluster for CDK13:

    Cyclin-dependent kinase 13
    Hs.233552  [show with all ESTs]
    Unigene Representative Sequence: NM_003718
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000181839(uc003thh.4 uc003thi.4 uc003thj.3 uc003thk.3)
    ENST00000340829 ENST00000484589(uc011kbf.2) ENST00000478563 ENST00000465643


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): CDK13
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK13
    8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK13 (see all 90):
    hsa-miR-100* hsa-miR-607 hsa-miR-4272 hsa-miR-218-1* hsa-miR-200a hsa-miR-938 hsa-miR-219-5p hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmid: CDK13 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK13 (see all 4)
    OriGene shRNA RFP: CDK13
    OriGene siRNA: CDK13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK13
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK13 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK13 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CDK13 (NM_003718)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK13 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK13

    Additional cDNA sequence: 

    AB058694.1 AJ297709.1 AJ297710.1 AK024379.1 AK025500.1 AK092534.1 AK130653.1 AK223053.1 
    BC001274.1 BC064414.1 BC080601.1 BX647326.1 M80629.1 

    14 DOTS entries:

    DT.95278134  DT.311636  DT.95278135  DT.95243679  DT.100800041  DT.91706778  DT.91739289  DT.95352052 
    DT.40317344  DT.100784997  DT.103736  DT.95206199  DT.99927496  DT.439966 

    24/280 AceView cDNA sequences (see all 280):

    AJ297710 CD722815 NM_031267 BM785494 BC001274 BU687243 AA278603 AW501762 
    BU742441 BM726619 BF111100 AA918354 AA319943 AI818388 AI598212 BU561639 
    AA296511 AI288556 AA479217 AA977044 BU682641 CA411847 AI122576 AI346223 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CDK13 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
    SP1:                                                                    -                                                               
    SP2:                                                                    -                 -                       -     -               
    SP3:                                                                                      -                       -                     
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for CDK13

    Expression
    for CDK13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAGCCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CDK13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK13

    SOURCE GeneReport for Unigene cluster: Hs.233552

    UniProtKB/Swiss-Prot: CDK13_HUMAN, Q14004
    Tissue specificity: Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and
    glioblastoma tumors

        SABiosciences Custom PCR Arrays for CDK13
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK13
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK13
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK13
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK13

    Orthologs
    for CDK13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK13 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDK131 cyclin-dependent kinase 13 78.19(n)
    80.35(a)    		   420766  XM_418864.3  XP_418864.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CDK136
    		 --
    		 77(a)
    		 1 ↔ 1
    		 6(48864614-48906618)
    African clawed frog
    (Xenopus laevis)    		 Amphibia 480599052   -- 74.81(n)    48059905 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi49c052 Transcribed sequence with strong similarity to protein more 76.65(n)    CA974951.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cdk121 CG7597-PA 47.77(n)
    46.29(a)    		   40385  NM_141068.2  NP_649325.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea cdtl-71 Protein CDTL-7 49.09(n)
    42.77(a)    		   175559  NM_065472.3  NP_497873.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CDKC21 cyclin-dependent kinase C-2 56.09(n)
    52.87(a)    		   836620  NM_125895.4  NP_201301.1 
    rice
    (Oryza sativa)    		 Liliopsida Os05g03897001 hypothetical protein 53.19(n)
    49.47(a)    		   4338674  NM_001061971.1  NP_001055436.1 


    ENSEMBL Gene Tree for CDK13 (if available)
    TreeFam Gene Tree for CDK13 (if available) 

    Paralogs
    for CDK13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK13 gene
    CDK122  CDK92  
    5 SIMAP similar genes for CDK13 using alignment to 1 protein entry:     CDK13_HUMAN:
    CDK7    CDK12    CDK6    MAPK14    MAPK13

    CDK13 for paralogs           About GeneDecksing



    Genomic Variants
    for CDK13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2571 NCBI SNPs in CDK13 are shown (see all 2571)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs126721361,2
    		C,F,H,--39988329(+) AATGAG/AATGTG 2 -- us2k15Minor allele frequency- A:0.18NA NS EA 406
    rs174960601,2
    		C,F,--39988381(+) ATATGA/GAGGTG 2 -- us2k12Minor allele frequency- G:0.06NS NA 298
    rs174960671,2
    		C,F,--39988426(+) TCGCAC/GAAGAT 2 -- us2k11Minor allele frequency- G:0.01NS 178
    rs69437581,2
    		C,--39988501(+) TTCCTA/GTATTG 2 -- us2k10--------
    rs1481178091,2
    		--39988518(+) AGCTTA/TAAAAA 2 -- us2k10--------
    rs126721421,2
    		C,F,H,--39988551(+) GTTACC/GGAAGC 2 -- us2k15Minor allele frequency- G:0.18NS NA EA 418
    rs175376021,2
    		C,F,--39988560(+) GCTTGA/GGCTGT 2 -- us2k11Minor allele frequency- G:0.01NS 176
    rs175376091,2
    		F--39988580(+) TTTTT-/TAGGAT 2 -- us2k11Minor allele frequency- T:0.01NS 176
    rs1909841211,2
    		--39988718(+) CGTACA/GTGAGA 2 -- us2k10--------
    rs1418258491,2
    		--39988721(+) ACGTGA/GGACAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK13 (39989636 - 40136733 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CDK13
         3 CNVs: 2692 8555 64803

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK13
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK13

    Disorders / Diseases
    for CDK13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDK13 for disorders           About GeneDecksing

    OMIM gene information: 603309    OMIM disorders: --

    8 diseases for CDK13:    About MalaCards
    ellis-van creveld syndrome    hematopoiesis    invasive aspergillosis    corneal dystrophy
    aspergillosis    glioblastoma    neuroblastoma    immunodeficiency

    Human Genome Epidemiology (HuGE) Navigator: CDK13 (1 document)

    Export disorders for CDK13 gene to outside databases

    Publications
    for CDK13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK13 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with CDK13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis. (PubMed id 1731328)1, 2, 3, 9 Lapidot-Lifson Y.... Soreq H. (1992)
    2. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    3. CDK13, a new potential human immunodeficiency virus type 1 inhibitory factor regulating viral mRNA splicing. (PubMed id 18480452)1, 2 Berro R....Kashanchi F. (2008)
    4. CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo. (PubMed id 16721827)1, 2 Even Y....Geneviere A.M. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    8. A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE. (PubMed id 11162436)1, 2 Marques F.... Geneviere A.M. (2001)
    9. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for CDK13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDK13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8621 HGNC: 1733 AceView: CDC2L5 Ensembl:ENSG00000065883 euGenes: HUgn8621
    ECgene: CDK13 H-InvDB: CDK13

    Other Databases showing CDK13 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1791

    Specialized Databases showing CDK13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK13 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc2l5/

    Intellectual Property
    for CDK13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDK13 gene:
    Search GeneIP for patents involving CDK13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CDK13 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CDK13  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK13   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK13  
     OriGene Protein Over-expression Lysate for CDK13   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CDK13   OriGene 3'-UTR Clone for CDK13  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK13   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK13  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDK13   OriGene Custom Protein Services for CDK13  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK13
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK13
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK13
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK13
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK13
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK13
     GenScript Custom Purified and Recombinant Proteins Services for CDK13 GenScript cDNA clones with any tag delivered in your preferred vector for CDK13
     GenScript Custom Assay Services for CDK13 GenScript Custom Superior Antibodies Services for CDK13
     GenScript Custom overexpressing Cell Line Services for CDK13 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for CDK13
     Search Chromatin IP Primers for CDK13
     RT2 qPCR Primer Assay in human, mouse, rat CDK13
     Search GNC Networks for CDK13
     SABiosciences Custom PCR Arrays for CDK13
     Search Tocris compounds for CDK13
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CDK13 antibodies
     CDK13 proteins
     CDK13 lysates
     Search for Antibodies for CDK13 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CDK13
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CDK13 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CDK13
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK13
     SwitchGear 3'UTR luciferase reporter plasmids for CDK13
     SwitchGear Promoter luciferase reporter plasmids for CDK13
     ThermoFisher Antibodies for CDK13
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK13
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CDK13 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4