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Aliases for CDK13 Gene

Aliases for CDK13 Gene

  • Cyclin-Dependent Kinase 13 2 3
  • Cholinesterase-Related Cell Division Controller 2 3 4
  • CDC2L5 3 4 6
  • CHED 3 4 6
  • Cell Division Cycle 2-Like Protein Kinase 5 3 4
  • Cell Division Protein Kinase 13 3 4
  • CDC2-Related Protein Kinase 5 3 4
  • EC 2.7.11.22 4 63
  • HCDK13 3 4
  • CDC2L 3 4
  • Cell Division Cycle 2-Like 5 (Cholinesterase-Related Cell Division Controller) 2
  • EC 2.7.11.23 4
  • EC 2.7.11 63
  • KIAA1791 4

External Ids for CDK13 Gene

Previous HGNC Symbols for CDK13 Gene

  • CDC2L5

Previous GeneCards Identifiers for CDK13 Gene

  • GC07P039957
  • GC07P039875

Summaries for CDK13 Gene

Entrez Gene Summary for CDK13 Gene

  • The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]

GeneCards Summary for CDK13 Gene

CDK13 (Cyclin-Dependent Kinase 13) is a Protein Coding gene. GO annotations related to this gene include protein kinase activity and RNA polymerase II carboxy-terminal domain kinase activity. An important paralog of this gene is CDK12.

UniProtKB/Swiss-Prot for CDK13 Gene

  • Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at Lys-50 and Lys-51, thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.

Gene Wiki entry for CDK13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK13 Gene

Genomics for CDK13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDK13 Gene

Start:
39,950,037 bp from pter
End:
40,097,134 bp from pter
Size:
147,098 bases
Orientation:
Plus strand

Genomic View for CDK13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK13 Gene

No data available for Regulatory Elements for CDK13 Gene

Proteins for CDK13 Gene

  • Protein details for CDK13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14004-CDK13_HUMAN
    Recommended name:
    Cyclin-dependent kinase 13
    Protein Accession:
    Q14004
    Secondary Accessions:
    • Q53G78
    • Q6DKQ9
    • Q75MH4
    • Q75MH5
    • Q96JN4
    • Q9H4A0
    • Q9H4A1
    • Q9UDR4

    Protein attributes for CDK13 Gene

    Size:
    1512 amino acids
    Molecular mass:
    164923 Da
    Quaternary structure:
    • Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK. Interacts with C1QBP. Interacts with HIV-1 Tat.
    SequenceCaution:
    • Sequence=AAA58424.1; Type=Frameshift; Positions=1006; Evidence={ECO:0000305}; Sequence=AAS07490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK13 Gene

Proteomics data for CDK13 Gene at MOPED

Post-translational modifications for CDK13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK13 Gene

Domains for CDK13 Gene

Gene Families for CDK13 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

Suggested Antigen Peptide Sequences for CDK13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14004

UniProtKB/Swiss-Prot:

CDK13_HUMAN :
  • Q14004
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK13: view

Function for CDK13 Gene

Molecular function for CDK13 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at Lys-50 and Lys-51, thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.

Enzyme Numbers (IUBMB) for CDK13 Gene

Gene Ontology (GO) - Molecular Function for CDK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 1731328
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16721827
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK13: view
genes like me logo Genes that share phenotypes with CDK13: view

Animal Model Products

miRNA for CDK13 Gene

miRTarBase miRNAs that target CDK13

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK13

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK13 Gene

Localization for CDK13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK13 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK13 Gene COMPARTMENTS Subcellular localization image for CDK13 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CDK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002945 cyclin K-CDK13 complex IPI 22012619
GO:0005615 extracellular space IDA 22664934
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with CDK13: view

Pathways for CDK13 Gene

SuperPathways for CDK13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome TAS 16721827
GO:0006468 protein phosphorylation --
GO:0007088 regulation of mitotic nuclear division TAS 1731328
GO:0007275 multicellular organismal development TAS 1731328
GO:0008284 positive regulation of cell proliferation TAS 1731328
genes like me logo Genes that share ontologies with CDK13: view

No data available for Pathways by source for CDK13 Gene

Compounds for CDK13 Gene

(2) HMDB Compounds for CDK13 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with CDK13: view

Transcripts for CDK13 Gene

Unigene Clusters for CDK13 Gene

Cyclin-dependent kinase 13:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
SP1: -
SP2: - - - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for CDK13 Gene

GeneLoc Exon Structure for
CDK13
ECgene alternative splicing isoforms for
CDK13

Expression for CDK13 Gene

mRNA expression in normal human tissues for CDK13 Gene

Protein differential expression in normal tissues for CDK13 Gene

This gene is overexpressed in Tlymphocyte (29.5), Lung (11.6), and Blymphocyte (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK13 Gene

SOURCE GeneReport for Unigene cluster for CDK13 Gene Hs.233552

mRNA Expression by UniProt/SwissProt for CDK13 Gene

Q14004-CDK13_HUMAN
Tissue specificity: Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors
genes like me logo Genes that share expressions with CDK13: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Expression partners for CDK13 Gene

Orthologs for CDK13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDK13 35
  • 93.91 (n)
  • 96.56 (a)
CDK13 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk13 35
  • 92.58 (n)
  • 95.56 (a)
Cdk13 16
Cdk13 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDK13 35
  • 99.76 (n)
  • 99.8 (a)
CDK13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk13 35
  • 91.83 (n)
  • 95.16 (a)
dog
(Canis familiaris)
Mammalia CDK13 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK13 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK13 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK13 35
  • 79.42 (n)
  • 82.36 (a)
CDK13 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK13 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk13 35
  • 67.06 (n)
  • 67.62 (a)
zebrafish
(Danio rerio)
Actinopterygii wufi49c05 35
cdk13 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cdk12 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdk-12 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 36
  • 35 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.1158 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10559 36
  • 54 (a)
OneToMany
Species with no ortholog for CDK13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK13 Gene

ENSEMBL:
Gene Tree for CDK13 (if available)
TreeFam:
Gene Tree for CDK13 (if available)

Paralogs for CDK13 Gene

Paralogs for CDK13 Gene

Selected SIMAP similar genes for CDK13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDK13: view

Variants for CDK13 Gene

Sequence variations from dbSNP and Humsavar for CDK13 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs699513 -- 40,037,433(+) cttcc(A/G)caaag intron-variant
rs699514 -- 40,038,210(+) ATATA(A/T)AAAAA intron-variant
rs731847 -- 40,071,105(+) GGGAA(A/G)CTTCC intron-variant
rs731848 -- 40,071,121(+) TGAAA(A/G)AAATG intron-variant
rs758695 -- 40,071,804(+) ttcca(A/G)tttta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK13 Gene

Variant ID Type Subtype PubMed ID
dgv7252n71 CNV Gain 21882294
dgv7253n71 CNV Loss 21882294
nsv464436 CNV Gain 19166990
nsv521293 CNV Loss 19592680
nsv518849 CNV Loss 19592680
nsv887978 CNV Loss 21882294
esv2734303 CNV Deletion 23290073
esv2666237 CNV Deletion 23128226
esv25464 CNV Loss 19812545
esv2656647 CNV Deletion 23128226
dgv2077e1 CNV Complex 17122850
dgv7254n71 CNV Gain 21882294
esv34547 CNV Gain 17911159
nsv824080 CNV Gain 20364138
esv273555 CNV Insertion 20981092
esv2669384 CNV Deletion 23128226
nsv464437 CNV Gain 19166990
nsv887982 CNV Gain 21882294

Relevant External Links for CDK13 Gene

HapMap Linkage Disequilibrium report
CDK13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK13 Gene

Disorders for CDK13 Gene

Relevant External Links for CDK13

Human Genome Epidemiology (HuGE) Navigator
CDK13

No disorders were found for CDK13 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CDK13 Gene

Publications for CDK13 Gene

  1. Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis. (PMID: 1731328) Lapidot-Lifson Y. … Soreq H. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23
  2. A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE. (PMID: 11162436) Marques F. … Geneviere A.M. (Biochem. Biophys. Res. Commun. 2000) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4

Products for CDK13 Gene

Sources for CDK13 Gene

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