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CDK13 Gene

protein-coding   GIFtS: 57
GCID: GC07P039957

Cyclin-Dependent Kinase 13

(Previous name: cell division cycle 2-like 5 (cholinesterase-related cell...)
(Previous symbol: CDC2L5)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 131 2     CDC2-Related Protein Kinase 52 3
CDC2L51 2 3 5     hCDK132 3
Cholinesterase-Related Cell Division Controller1 2 3     EC 2.7.11.223 8
CHED2 3 5     Cell Division Cycle 2-Like 5 (Cholinesterase-Related Cell Division
Controller)1
Cell Division Cycle 2-Like Protein Kinase 52 3     EC 2.7.11.233
Cell Division Protein Kinase 132 3     KIAA17913
CDC2L2 3     EC 2.7.118

External Ids:    HGNC: 17331   Entrez Gene: 86212   Ensembl: ENSG000000658837   OMIM: 6033095   UniProtKB: Q140043   

Export aliases for CDK13 gene to outside databases

Previous GC identifer: GC07P039875


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK13 Gene:
The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family.
Members of this family are well known for their essential roles as master switches in cell cycle control. The
exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be
involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.(provided
by RefSeq, Dec 2009)

GeneCards Summary for CDK13 Gene:
CDK13 (cyclin-dependent kinase 13) is a protein-coding gene. Diseases associated with CDK13 include ellis-van creveld syndrome, and invasive aspergillosis. GO annotations related to this gene include RNA polymerase II carboxy-terminal domain kinase activity and protein kinase activity. An important paralog of this gene is CDK11A.

UniProtKB/Swiss-Prot: CDK13_HUMAN, Q14004
Function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD
kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA
polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA
splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1
virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA
splicing and promoting the production of the doubly spliced HIV-1 protein Nef

Gene Wiki entry for CDK13 (CDC2L5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CDK13
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): CDK13 promoter sequence
   Search Chromatin IP Primers for CDK13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14.1

CDK13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK13 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P039957:  view genomic region     (about GC identifiers)

Start:
39,989,636 bp from pter      End:
40,136,733 bp from pter
Size:
147,098 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 40,028,472-40,175,171     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CDK13_HUMAN, Q14004 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 13  
Size: 1512 amino acids; 164923 Da
Subunit: Interacts with CCNL1 and CCNL2 (By similarity). Interacts with C1QBP. Interacts with HIV-1 Tat
Rna editing: Modified_positions=103; Note=Edited at about 88%
Sequence caution: Sequence=AAA58424.1; Type=Frameshift; Positions=1006; Sequence=AAS07490.1; Type=Erroneous gene
model prediction;
Secondary accessions: Q53G78 Q6DKQ9 Q75MH4 Q75MH5 Q96JN4 Q9H4A0 Q9H4A1 Q9UDR4
Alternative splicing: 2 isoforms:  Q14004-1   Q14004-2   

Explore the universe of human proteins at neXtProt for CDK13: NX_Q14004

Explore proteomics data for CDK13 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK13 (Q14004) (see all 16)
     LADFGLA  FLHRDIK  IGEGTYG  NMKEIVTDK 


    See CDK13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003709.3  NP_112557.2  

    ENSEMBL proteins: 
     ENSP00000181839   ENSP00000340557  

    CDK13 Human Recombinant Protein Products:

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    CDK13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CDK13
    Cloud-Clone Corp. CLIAs for CDK13


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 13
    CRK7 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q14004

    ProtoNet protein and cluster: Q14004

    UniProtKB/Swiss-Prot: CDK13_HUMAN, Q14004
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK13_HUMAN, Q14004
    Function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD
    kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA
    polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA
    splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1
    virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA
    splicing and promoting the production of the doubly spliced HIV-1 protein Nef
    Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.11.231 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS1731328
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16721827
    GO:0005524ATP binding IEA--
         
    CDK13 for ontologies           About GeneDecksing


    Phenotypes:
         10 GenomeRNAi human phenotypes for CDK13:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Decreased viability  G0/1 arrest 
     Increased G1 DNA content  Increased mitotic index  Stronger migration  Synthetic lethal with Ras 
     Synthetic lethal with c-Myc af  Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Cdk13 (no phenotypes)

    CDK13 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdk13tm1Lex for CDK13

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK13
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK13
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK13

    miRNA
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    hsa-mir-29b-2-5p (MIRT038713), hsa-mir-133b (MIRT007125)

    Block miRNA regulation of human, mouse, rat CDK13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK13 (see all 90):
    hsa-miR-100* hsa-miR-607 hsa-miR-4272 hsa-miR-218-1* hsa-miR-200a hsa-miR-938 hsa-miR-219-5p hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidCDK13 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDK13

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CDK13 (NM_003718)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK13

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDK13_HUMAN, Q14004: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002945cyclin K-CDK13 complex IPI--
    GO:0005615extracellular space IDA--
    GO:0016607nuclear speck IDA16721827
    GO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex ISS--

    CDK13 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK13
    Interactions:

        Search GeneGlobe Interaction Network for CDK13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK13 (Q140041, 2, 3 ENSP000001818394) via UniProtKB, MINT, STRING, and/or I2D (see all 191)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61855 I2D: score=3 
    CHMP4AQ9BY433, ENSP000003242054I2D: score=1 STRING: ENSP00000324205
    TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    ALKQ9UM733, ENSP000003737004I2D: score=1 STRING: ENSP00000373700
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000380alternative mRNA splicing, via spliceosome TAS16721827
    GO:0006468protein phosphorylation ----
    GO:0007088regulation of mitosis TAS1731328
    GO:0007275multicellular organismal development TAS1731328
    GO:0008284positive regulation of cell proliferation TAS1731328

    CDK13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDK13

    2 HMDB Compounds for CDK13    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDK13 gene (2 alternative transcripts): 
    NM_003718.4  NM_031267.3  

    Unigene Cluster for CDK13:

    Cyclin-dependent kinase 13
    Hs.233552  [show with all ESTs]
    Unigene Representative Sequence: NM_003718
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000181839(uc003thh.4 uc003thi.4 uc003thj.3 uc003thk.3)
    ENST00000340829 ENST00000484589(uc011kbf.2) ENST00000478563 ENST00000465643

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat CDK13 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDK13 (see all 90):
    hsa-miR-100* hsa-miR-607 hsa-miR-4272 hsa-miR-218-1* hsa-miR-200a hsa-miR-938 hsa-miR-219-5p hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidCDK13 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK13
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK13
      QuantiTect SYBR Green Assays in human, mouse, rat CDK13
      QuantiFast Probe-based Assays in human, mouse, rat CDK13

    Additional mRNA sequence: 

    AB058694.1 AJ297709.1 AJ297710.1 AK024379.1 AK025500.1 AK092534.1 AK130653.1 AK223053.1 
    BC001274.1 BC064414.1 BC080601.1 BX647326.1 M80629.1 

    14 DOTS entries:

    DT.95278134  DT.311636  DT.95278135  DT.95243679  DT.100800041  DT.91706778  DT.91739289  DT.95352052 
    DT.40317344  DT.100784997  DT.103736  DT.95206199  DT.99927496  DT.439966 

    Selected AceView cDNA sequences (see all 280):

    CF143599 AW772215 AJ297710 AI094087 AI801836 BU742441 AW182132 AI288556 
    AA331749 AI818388 BM129386 AA227573 AW665412 BE745598 BC001274 BQ716600 
    AI076449 BX474749 AA947897 BU561639 BU682641 R83723 BQ575530 BC080601 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK13 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
    SP1:                                                                    -                                                               
    SP2:                                                                    -                 -                       -     -               
    SP3:                                                                                      -                       -                     
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for CDK13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAGCCTGT
    CDK13 Expression
    About this image

    CDK13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.233552

    UniProtKB/Swiss-Prot: CDK13_HUMAN, Q14004
    Tissue specificity: Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma
    and glioblastoma tumors

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK13 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk131 , 5 cyclin-dependent kinase 131, 5 92.58(n)1
    95.56(a)1
      13 (6.05 cM)5
    695621  NM_001081058.21  NP_001074527.11 
     177159625 
    chicken
    (Gallus gallus)
    Aves CDK131 cyclin-dependent kinase 13 79.42(n)
    82.36(a)
      420766  XM_418864.4  XP_418864.4 
    lizard
    (Anolis carolinensis)
    Reptilia CDK136
    cyclin-dependent kinase 13
    77(a)
    1 ↔ 1
    6(48864614-48906618)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480599052   -- 74.81(n)    48059905 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi49c052 Transcribed sequence with strong similarity to protein more 76.65(n)    CA974951.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk126
    --
    33(a)
    1 → many
    3L(21509406-21515786)
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-126
    Protein CDK-12, isoform b (cdk-12) mRNA, complete ...
    38(a)
    1 → many
    III(4333396-4340483) WBGene00007135
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTK16
    Catalytic (alpha) subunit of C-terminal domain kin...
    35(a)
    1 → many
    XI(182958-184544) YKL139W
    corn
    (Zea mays)
    Liliopsida Zm.11582 Zea mays PCO084426 mRNA sequence 69.73(n)    AY107067.1 


    ENSEMBL Gene Tree for CDK13 (if available)
    TreeFam Gene Tree for CDK13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK13 gene
    CDK11A2  CDK122  CDK102  CDK92  CDK11B2  
    5 SIMAP similar genes for CDK13 using alignment to 1 protein entry:     CDK13_HUMAN:
    CDK7    CDK12    CDK6    MAPK14    MAPK13

    CDK13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK13 (see all 3159)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs126721361,2
    C,F,H--39988329(+) AATGAG/AATGTG 2 -- us2k15Minor allele frequency- A:0.18NA NS EA 406
    rs174960601,2
    C,F--39988381(+) ATATGA/GAGGTG 2 -- us2k12Minor allele frequency- G:0.06NS NA 298
    rs174960671,2
    C,F--39988426(+) TCGCAC/GAAGAT 2 -- us2k11Minor allele frequency- G:0.01NS 178
    rs69437581,2
    C--39988501(+) TTCCTA/GTATTG 2 -- us2k10--------
    rs1481178091,2
    --39988518(+) AGCTTA/TAAAAA 2 -- us2k10--------
    rs126721421,2
    C,F,H--39988551(+) GTTACC/GGAAGC 2 -- us2k15Minor allele frequency- G:0.18NS NA EA 418
    rs175376021,2
    C,F--39988560(+) GCTTGA/GGCTGT 2 -- us2k11Minor allele frequency- G:0.01NS 176
    rs175376091,2
    C,F--39988579(+) TTTTT-/TAGGAT 2 -- us2k11Minor allele frequency- T:0.01NS 176
    rs58837101,2
    C--39988675(+) aaaaa-/A/AA  
            
    aaaaa
    2 -- us2k11NA 2
    rs560215191,2
    C--39988694(+) AAAAA-/A/AA  
            
    TGGGG
    2 -- us2k11NA 2

    HapMap Linkage Disequilibrium report for CDK13 (39989636 - 40136733 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CDK13 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734303CNV Deletion23290073
    esv2656647CNV Deletion23128226
    esv2666237CNV Deletion23128226
    esv2669384CNV Deletion23128226
    esv273555CNV Insertion20981092
    nsv518849CNV Loss19592680
    nsv887978CNV Loss21882294
    nsv521293CNV Loss19592680
    esv25464CNV Loss19812545
    dgv7253n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603309    OMIM disorders: --

    8 diseases for CDK13:    About MalaCards
    ellis-van creveld syndrome    invasive aspergillosis    aspergillosis    corneal dystrophy
    hiv-1    neuroblastoma    hepatocellular carcinoma    malaria


    CDK13 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: CDK13 (1 document)

    Export disorders for CDK13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK13 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with CDK13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis. (PubMed id 1731328)1, 2, 3, 9 Lapidot-Lifson Y.... Soreq H. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (Nat. Cell Biol. 2009)
    3. CDK13, a new potential human immunodeficiency virus type 1 inhibitory factor regulating viral mRNA splicing. (PubMed id 18480452)1, 2 Berro R.... Kashanchi F. (J. Virol. 2008)
    4. CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2- associated protein p32 and affects splicing in vivo. (PubMed id 16721827)1, 2 Even Y.... Geneviere A.M. (J. Cell. Biochem. 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    9. A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE. (PubMed id 11162436)1, 2 Marques F.... Geneviere A.M. (Biochem. Biophys. Res. Commun. 2000)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8621 HGNC: 1733 AceView: CDC2L5 Ensembl:ENSG00000065883 euGenes: HUgn8621
    ECgene: CDK13 H-InvDB: CDK13

    (According to HUGE)
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    HUGE: KIAA1791

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDK13 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc2l5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK13 gene:
    Search GeneIP for patents involving CDK13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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