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Aliases for CDK13 Gene

Aliases for CDK13 Gene

  • Cyclin-Dependent Kinase 13 2 3 5
  • Cholinesterase-Related Cell Division Controller 2 3 4
  • Cell Division Cycle 2-Like Protein Kinase 5 3 4
  • Cell Division Protein Kinase 13 3 4
  • CDC2-Related Protein Kinase 5 3 4
  • EC 2.7.11.22 4 63
  • CDC2L5 3 4
  • HCDK13 3 4
  • CDC2L 3 4
  • CHED 3 4
  • Cell Division Cycle 2-Like 5 (Cholinesterase-Related Cell Division Controller) 2
  • EC 2.7.11.23 4
  • EC 2.7.11 63
  • KIAA1791 4

External Ids for CDK13 Gene

Previous HGNC Symbols for CDK13 Gene

  • CDC2L5

Previous GeneCards Identifiers for CDK13 Gene

  • GC07P039957
  • GC07P039875

Summaries for CDK13 Gene

Entrez Gene Summary for CDK13 Gene

  • The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]

GeneCards Summary for CDK13 Gene

CDK13 (Cyclin-Dependent Kinase 13) is a Protein Coding gene. Diseases associated with CDK13 include hiv-1 and corneal dystrophy, posterior polymorphous, 1. Among its related pathways are Gene Expression and Formation of the HIV-1 Early Elongation Complex. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is CDK12.

UniProtKB/Swiss-Prot for CDK13 Gene

  • Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at Lys-50 and Lys-51, thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.

Gene Wiki entry for CDK13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK13 Gene

Genomics for CDK13 Gene

Regulatory Elements for CDK13 Gene

Enhancers for CDK13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDK13 on UCSC Golden Path with GeneCards custom track

Promoters for CDK13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDK13 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDK13 Gene

Chromosome:
7
Start:
39,949,838 bp from pter
End:
40,097,134 bp from pter
Size:
147,297 bases
Orientation:
Plus strand

Genomic View for CDK13 Gene

Genes around CDK13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK13 Gene

Proteins for CDK13 Gene

  • Protein details for CDK13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14004-CDK13_HUMAN
    Recommended name:
    Cyclin-dependent kinase 13
    Protein Accession:
    Q14004
    Secondary Accessions:
    • Q53G78
    • Q6DKQ9
    • Q75MH4
    • Q75MH5
    • Q96JN4
    • Q9H4A0
    • Q9H4A1
    • Q9UDR4

    Protein attributes for CDK13 Gene

    Size:
    1512 amino acids
    Molecular mass:
    164923 Da
    Quaternary structure:
    • Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK. Interacts with C1QBP. Interacts with HIV-1 Tat.
    SequenceCaution:
    • Sequence=AAA58424.1; Type=Frameshift; Positions=1006; Evidence={ECO:0000305}; Sequence=AAS07490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK13 Gene

    Alternative splice isoforms for CDK13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK13 Gene

Proteomics data for CDK13 Gene at MOPED

Post-translational modifications for CDK13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK13 Gene

Domains & Families for CDK13 Gene

Gene Families for CDK13 Gene

Suggested Antigen Peptide Sequences for CDK13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14004

UniProtKB/Swiss-Prot:

CDK13_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK13: view

Function for CDK13 Gene

Molecular function for CDK13 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at Lys-50 and Lys-51, thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.

Enzyme Numbers (IUBMB) for CDK13 Gene

Gene Ontology (GO) - Molecular Function for CDK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,TAS 1731328
genes like me logo Genes that share ontologies with CDK13: view
genes like me logo Genes that share phenotypes with CDK13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDK13

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK13 Gene

Localization for CDK13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK13 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK13 Gene COMPARTMENTS Subcellular localization image for CDK13 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CDK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA,TAS --
genes like me logo Genes that share ontologies with CDK13: view

Pathways & Interactions for CDK13 Gene

genes like me logo Genes that share pathways with CDK13: view

Pathways by source for CDK13 Gene

Gene Ontology (GO) - Biological Process for CDK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0008284 positive regulation of cell proliferation TAS 1731328
GO:0016032 viral process IEA --
GO:0030097 hemopoiesis IMP 1731328
genes like me logo Genes that share ontologies with CDK13: view

No data available for SIGNOR curated interactions for CDK13 Gene

Drugs & Compounds for CDK13 Gene

(1) Drugs for CDK13 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for CDK13 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK13: view

Transcripts for CDK13 Gene

Unigene Clusters for CDK13 Gene

Cyclin-dependent kinase 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
SP1: -
SP2: - - - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for CDK13 Gene

GeneLoc Exon Structure for
CDK13
ECgene alternative splicing isoforms for
CDK13

Expression for CDK13 Gene

mRNA expression in normal human tissues for CDK13 Gene

Protein differential expression in normal tissues from HIPED for CDK13 Gene

This gene is overexpressed in Tlymphocyte (29.5), Lung (11.6), and Blymphocyte (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK13 Gene



SOURCE GeneReport for Unigene cluster for CDK13 Gene Hs.233552

mRNA Expression by UniProt/SwissProt for CDK13 Gene

Q14004-CDK13_HUMAN
Tissue specificity: Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.
genes like me logo Genes that share expression patterns with CDK13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDK13 Gene

Orthologs for CDK13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDK13 35
  • 93.91 (n)
  • 96.56 (a)
CDK13 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk13 35
  • 92.58 (n)
  • 95.56 (a)
Cdk13 16
Cdk13 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDK13 35
  • 99.76 (n)
  • 99.8 (a)
CDK13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk13 35
  • 91.83 (n)
  • 95.16 (a)
dog
(Canis familiaris)
Mammalia CDK13 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK13 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDK13 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK13 35
  • 79.42 (n)
  • 82.36 (a)
CDK13 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK13 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk13 35
  • 67.06 (n)
  • 67.62 (a)
zebrafish
(Danio rerio)
Actinopterygii wufi49c05 35
cdk13 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cdk12 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdk-12 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 36
  • 35 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.1158 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10559 36
  • 54 (a)
OneToMany
Species with no ortholog for CDK13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK13 Gene

ENSEMBL:
Gene Tree for CDK13 (if available)
TreeFam:
Gene Tree for CDK13 (if available)

Paralogs for CDK13 Gene

Paralogs for CDK13 Gene

(5) SIMAP similar genes for CDK13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDK13: view

Variants for CDK13 Gene

Sequence variations from dbSNP and Humsavar for CDK13 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17537669 - 39,951,707(+) GGCTG(C/G)CGCGC reference, missense
rs3735137 - 39,951,848(-) CCTGA(A/G)CACAG reference, missense
rs17496261 - 39,987,616(+) ATCCC(A/G)AAGCA reference, missense
rs3735135 - 39,987,885(-) TTCCG(C/T)GTTCC reference, missense
rs17496275 - 39,988,257(+) CTGAT(A/G)GGTAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDK13 Gene

Variant ID Type Subtype PubMed ID
dgv7252n71 CNV Gain 21882294
dgv7253n71 CNV Loss 21882294
nsv464436 CNV Gain 19166990
nsv521293 CNV Loss 19592680
nsv518849 CNV Loss 19592680
nsv887978 CNV Loss 21882294
esv2734303 CNV Deletion 23290073
esv2666237 CNV Deletion 23128226
esv25464 CNV Loss 19812545
esv2656647 CNV Deletion 23128226
dgv2077e1 CNV Complex 17122850
dgv7254n71 CNV Gain 21882294
esv34547 CNV Gain 17911159
nsv824080 CNV Gain 20364138
esv273555 CNV Insertion 20981092
esv2669384 CNV Deletion 23128226
nsv464437 CNV Gain 19166990
nsv887982 CNV Gain 21882294

Variation tolerance for CDK13 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.72; 78.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK13 Gene

HapMap Linkage Disequilibrium report
CDK13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK13 Gene

Disorders for CDK13 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CDK13 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
corneal dystrophy, posterior polymorphous, 1
  • posterior polymorphous corneal dystrophy
chandler syndrome
  • chandler's syndrome
corneal dystrophy, thiel-behnke type
  • thiel-behnke corneal dystrophy
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search CDK13 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDK13

Human Genome Epidemiology (HuGE) Navigator
CDK13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK13
genes like me logo Genes that share disorders with CDK13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK13 Gene

Publications for CDK13 Gene

  1. Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis. (PMID: 1731328) Lapidot-Lifson Y. … Soreq H. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23 67
  2. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3
  3. Structural and Functional Analysis of the Cdk13/Cyclin K Complex. (PMID: 26748711) Greifenberg A.K. … Geyer M. (Cell Rep 2016) 3
  4. Protein deep sequencing applied to biobank samples from patients with pancreatic cancer. (PMID: 25216700) Ansari D. … Marko-Varga G. (J. Cancer Res. Clin. Oncol. 2015) 3
  5. Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing. (PMID: 25561469) Liang K. … Shilatifard A. (Mol. Cell. Biol. 2015) 3

Products for CDK13 Gene

Sources for CDK13 Gene

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