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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK12 Gene

protein-coding   GIFtS: 56
GCID: GC17P037618

Cyclin-Dependent Kinase 12

(Previous names: Cdc2-related kinase, arginine/serine-rich)
(Previous symbol: CRKRS)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 121 2     EC 2.7.11.223 8
CRKRS1 2 3     CDC2 Related Protein Kinase 71
Cdc2-Related Kinase, Arginine/Serine-Rich1 2 3     CRKR2
Cell Division Cycle 2-Related Protein Kinase 72 3     CrkRS3
Cell Division Protein Kinase 122 3     EC 2.7.11.233
CRK72 3     KIAA09043
CDC2-Related Protein Kinase 72 3     EC 2.7.118
hCDK122 3     

External Ids:    HGNC: 242241   Entrez Gene: 517552   Ensembl: ENSG000001672587   UniProtKB: Q9NYV43   

Export aliases for CDK12 gene to outside databases

Previous GC identifers: GC17P034873 GC17P033411


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CDK12 Gene: 
CDK12 (cyclin-dependent kinase 12) is a protein-coding gene. Diseases associated with CDK12 include gastric cancer, and breast cancer, and among its related super-pathways are Cell Cycle / Checkpoint Control. GO annotations related to this gene include RNA polymerase II carboxy-terminal domain kinase activity and protein kinase activity. An important paralog of this gene is CDK13.

UniProtKB/Swiss-Prot: CDK12_HUMAN, Q9NYV4
Function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD
kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA
polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA
splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading
to affect the response to estrogn inhibitors

Gene Wiki entry for CDK12 (CRKRS) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK12
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK12 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

CDK12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK12 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P037618:  view genomic region     (about GC identifiers)

Start:
37,617,739 bp from pter      End:
37,721,160 bp from pter
Size:
103,422 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK12_HUMAN, Q9NYV4 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 12  
Size: 1490 amino acids; 164155 Da
Subunit: Interacts with CCNL1 and CCNL2 (By similarity)
Subcellular location: Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase
Sequence caution: Sequence=BAA74927.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7E2B2 B4DYX4 B9EIQ6 O94978
Alternative splicing: 3 isoforms:  Q9NYV4-1   Q9NYV4-2   Q9NYV4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK12: NX_Q9NYV4

Explore proteomics data for CDK12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYV4

  • 4/16 DME Specific Peptides for CDK12 (Q9NYV4) (see all 16)
     LADFGLA  FLHRDIK  IGEGTYG  NMKEIVTDK 

    CDK12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK12 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_055898.1  NP_057591.2  

    ENSEMBL proteins: 
     ENSP00000464641   ENSP00000407720   ENSP00000398880   ENSP00000453329  

    Human Recombinant Protein Products for CDK12: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK12 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002944cyclin K-CDK12 complex IPI--
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0016607nuclear speck IDA11683387
    GO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex ISS--

    CDK12 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 12 
    CRK7 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYV4

    ProtoNet protein and cluster: Q9NYV4

    UniProtKB/Swiss-Prot: CDK12_HUMAN, Q9NYV4
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK12_HUMAN, Q9NYV4
    Function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD
    kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA
    polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA
    splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading
    to affect the response to estrogn inhibitors
    Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.11.231 EC 2.7.112

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA11683387
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12841360
         
    CDK12 for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for CDK12:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased nuclei size in G2M 
     Decreased substrate adherent c  G0/1 arrest  Increased G1 DNA content  Increased viability with 4OH t 
     Upregulation of Wnt/beta-caten 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidCDK12 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK12 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    DNA Damage0.32
    Cell Cycle / Checkpoint Control0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for CDK12
        Cell Cycle / Checkpoint Control
    DNA Damage



    CDK12 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/616 Interacting proteins for CDK12 (Q9NYV42, 3 ENSP000003988804) via UniProtKB, MINT, STRING, and/or I2D (see all 616)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61865 MINT-7945693 I2D: score=5 
    SRRM2Q9UQ352, 3, ENSP000003017404MINT-7945693 I2D: score=1 STRING: ENSP00000301740
    POLR2AP249282, 3, ENSP000003149494MINT-7945693 I2D: score=2 STRING: ENSP00000314949
    SRSF1Q079552, 3, ENSP000002589624MINT-7945693 I2D: score=2 STRING: ENSP00000258962
    SRSF2Q011302, 3, ENSP000003508774MINT-7945693 I2D: score=2 STRING: ENSP00000350877
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006468protein phosphorylation ----
    GO:0008380RNA splicing ISS--
    GO:0043405regulation of MAP kinase activity IMP19651820
    GO:0046777protein autophosphorylation IDA11683387

    CDK12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK12

    2 HMDB Compounds for CDK12    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about CDK12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK12 gene (2 alternative transcripts): 
    NM_015083.1  NM_016507.2  

    Unigene Cluster for CDK12:

    Cyclin-dependent kinase 12
    Hs.416108  [show with all ESTs]
    Unigene Representative Sequence: NM_016507
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000584632(uc010wef.1) ENST00000430627 ENST00000447079(uc010cvv.3 uc002hrw.4)
    ENST00000581593 ENST00000559663 ENST00000584336 ENST00000581963 ENST00000559545
    ENST00000585161 ENST00000558240
    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK12 (see all 55):
    hsa-miR-4328 hsa-miR-429 hsa-miR-330-5p hsa-miR-15a hsa-miR-30d hsa-miR-105 hsa-miR-30a hsa-miR-424
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    Additional mRNA sequence: 

    AB020711.2 AF227198.1 AK302645.1 BC012428.1 BC140854.1 BC150265.1 

    13 DOTS entries:

    DT.407252  DT.97837995  DT.214006  DT.100716017  DT.120922935  DT.91889521  DT.95364481  DT.120922915 
    DT.120922953  DT.87014848  DT.91835016  DT.92434158  DT.99972837 

    24/199 AceView cDNA sequences (see all 199):

    AA810096 AI924966 AI457477 AA767576 AW593440 BG390612 AW005160 BE674496 
    AA480893 AA420967 AI693362 CR622325 AW193787 AI081228 CA454339 AI686820 
    BE466706 BX119213 AI830166 AA770088 AA490355 AI672119 AA490255 AI350744 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CDK12    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                                      -         
    SP2:                                                                                                


    ECgene alternative splicing isoforms for CDK12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK12 expression in normal human tissues (normalized intensities)      CDK12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATATAATT
    CDK12 Expression
    About this image


    CDK12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             nk cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See CDK12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK12

    SOURCE GeneReport for Unigene cluster: Hs.416108

    UniProtKB/Swiss-Prot: CDK12_HUMAN, Q9NYV4
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK12 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk121 , 5 cyclin-dependent kinase 121, 5 89.89(n)1
    91.71(a)1
      11 (61.75 cM)5
    691311  NM_001109626.11  NP_001103096.11 
     982030595 
    chicken
    (Gallus gallus)
    Aves CDK121 cyclin-dependent kinase 12 75.59(n)
    78.76(a)
      428306  XM_425866.3  XP_425866.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    76(a)
    64(a)
    1 ↔ many
    1 ↔ many
    6(67783549-67800200)
    6(67763234-67782997)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153242 Xenopus laevis transcribed sequence with weak similarity more 74.01(n)    BJ069786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001498341 cdc2-related kinase, arginine/serine-rich-like 57.85(n)
    60.68(a)
      100149834  XM_003200531.1  XP_003200579.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cdk126
    --
    32(a)
    1 → many
    3L(21509406-21515786)
    worm
    (Caenorhabditis elegans)
    Secernentea cdtl-76
    Cyclin-dependent kinase 12
    39(a)
    1 → many
    III(4333396-4340483)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTK16
    Catalytic (alpha) subunit of C-terminal domain kin...
    30(a)
    1 → many
    XI(182958-184544)
    rice
    (Oryza sativa)
    Liliopsida AK073808.12   -- 74.22(n)    AK073808.1 


    ENSEMBL Gene Tree for CDK12 (if available)
    TreeFam Gene Tree for CDK12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK12 gene
    CDK132  CDK92  
    18/65 SIMAP similar genes for CDK12 using alignment to 3 protein entries:     CDK12_HUMAN (see all proteins) (see all similar genes):
    PHKG2    CDKL2    MAP4K2    MAP4K5    CCRK    CDC2
    RPS6KA2    TXK    CDK10    CDK9    STK3    STK38L
    CDK7    CDK1    DYRK4    NDUFA9    RPS6KA1    STK11

    CDK12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1506 SNPs in CDK12 are shown (see all 1506)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419694
    A colorectal adenocarcinoma sample4--see VAR_0419692 R H mis40--------
    rs728251931,2
    C--37615744(+) GTGGCC/TCACGC 2 -- us2k10--------
    rs728251941,2
    C,F--37616064(+) CCTGTG/CAGCAA 2 -- us2k12Minor allele frequency- C:0.04NA EA 240
    rs1422716721,2
    --37616167(+) TCTCCA/GTTTTG 2 -- us2k10--------
    rs771133111,2
    F--37616239(+) CTGTTC/G/TTGAAG 2 -- us2k11NA 2
    rs1821661201,2
    --37616266(+) TAGGCA/GAAAGT 2 -- us2k10--------
    rs46114921,2
    C,F,H--37616337(+) TACTAT/CGCTTT 2 -- us2k1 tfbs318Minor allele frequency- C:0.03NS EA NA 2240
    rs1407255951,2
    --37616647(+) ATAATA/GTATGT 2 -- us2k10--------
    rs1870253861,2
    --37616731(+) TGTCCC/TGACAT 2 -- us2k10--------
    rs1923749991,2
    --37616962(+) GCGACC/TCTATA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK12 (37617739 - 37721160 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CDK12:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2263528CNV Deletion18987734
    esv2715903CNV Deletion23290073
    esv2715901CNV Deletion23290073
    esv2715902CNV Deletion23290073
    esv1352810CNV Deletion17803354
    dgv50n6CNV Loss16902084
    nsv827985CNV Loss20364138
    nsv908204CNV Gain21882294
    nsv819586CNV Gain19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UniProtKB/Swiss-Prot: CDK12_HUMAN, Q9NYV4
  • Note=Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region
    producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not
    in-frame with ERBB2

  • 2 diseases for CDK12:    About MalaCards
    gastric cancer    breast cancer


    CDK12 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: CDK12 (0 documents)

    Export disorders for CDK12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK12 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with CDK12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. (PubMed id 11683387)1, 2, 3, 9 Ko T.K.... Pines J. (2001)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    3. CDK12 is a transcription elongation-associated CTD ki nase, the metazoan ortholog of yeast Ctk1. (PubMed id 20952539)1, 2 Bartkowiak B....Greenleaf A.L. (2010)
    4. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    5. CRK7 modifies the MAPK pathway and influences the res ponse to endocrine therapy. (PubMed id 19651820)1, 2 Iorns E....Ashworth A. (2009)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51755 HGNC: 24224 AceView: CRK7 Ensembl:ENSG00000167258 euGenes: HUgn51755
    ECgene: CDK12 H-InvDB: CDK12

    (According to HUGE)
    About This Section
    HUGE: KIAA0904

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK12 gene:
    Search GeneIP for patents involving CDK12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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