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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK12 Gene

protein-coding   GIFtS: 55
GCID: GC17P037618

cyclin-dependent kinase 12

(Previous names: Cdc2-related kinase, arginine/serine-rich )
(Previous symbol: CRKRS)
 Explore 2 diseases affiliated with
CDK12 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDK12    

Aliases
for CDK12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase 121 2     Cell Division Protein Kinase 122 3
CRK71 2 3     CDC2-Related Protein Kinase 72 3
CRKRS1 2 3     HCDK121
Cdc2-Related Kinase, Arginine/Serine-Rich1 2 3     EC 2.7.11.223 8
CRKR1 2     CrkRS3
KIAA09041 3     EC 2.7.11.233
Cell Division Cycle 2-Related Protein Kinase 72 3     EC 2.7.118

External Ids:    HGNC: 242241   Entrez Gene: 517552   Ensembl: ENSG000001672587   UniProtKB: Q9NYV43   

Export aliases for CDK12 gene to outside databases

Previous GC identifers: GC17P034873 GC17P033411


Summaries
for CDK12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CDK12_HUMAN, Q9NYV4
Function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase
activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II
subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by
phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to
estrogn inhibitors

Gene Wiki entry for CDK12 (CRKRS)


Genomic Views
for CDK12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK12
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK12 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12

CDK12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK12 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P037618:  view genomic region     (about GC identifiers)

Start:
 37,617,739 bp from pter      End:
 37,721,160 bp from pter
Size:
 103,422 bases      Orientation:
 plus strand

Proteins
for CDK12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDK12_HUMAN, Q9NYV4 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 12  
Size: 1490 amino acids; 164155 Da
Subunit: Interacts with CCNL1 and CCNL2 (By similarity)
Subcellular location: Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase
Sequence caution: Sequence=BAA74927.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7E2B2 B4DYX4 B9EIQ6 O94978
Alternative splicing: 3 isoforms:  Q9NYV4-1   Q9NYV4-2   Q9NYV4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK12: NX_Q9NYV4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYV4

    • 4/16 DME Specific Peptides for CDK12 (Q9NYV4) (see all 16)
     LADFGLA  FLHRDIK  IGEGTYG  NMKEIVTDK 

    CDK12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_055898.1  NP_057591.2  

    ENSEMBL proteins: 
     ENSP00000464641   ENSP00000407720   ENSP00000398880   ENSP00000453329  

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    OriGene Protein Over-expression Lysate (see all 2): CDK12
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    Novus Biologicals CDK12 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDK12

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002944cyclin K-CDK12 complex IPI--
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0016607nuclear speck IDA11683387
    GO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex ISS--


    CDK12 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CDK12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDK12 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYV4

    ProtoNet protein and cluster: Q9NYV4

    UniProtKB/Swiss-Prot: CDK12_HUMAN, Q9NYV4
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CDK12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDK12_HUMAN, Q9NYV4
    Function: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase
    activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II
    subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by
    phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to
    estrogn inhibitors
    Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

    Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.11.231 EC 2.7.112

    miRNA
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    hsa-miR-4328 hsa-miR-429 hsa-miR-330-5p hsa-miR-15a hsa-miR-30d hsa-miR-105 hsa-miR-30a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: CDK12 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA11683387
    GO:0004693cyclin-dependent protein kinase activity IEA--
    GO:0005515protein binding IPI12841360
    GO:0005524ATP binding IEA--
    GO:0008353RNA polymerase II carboxy-terminal domain kinase activity IMP--


    CDK12 for ontologies           About GeneDecksing


    9 GenomeRNAi human phenotypes for CDK12:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased nuclei size in G2M 
     Decreased substrate adherent c  G0/1 arrest  Increased G1 DNA content  Increased viability with 4OH t 
     Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for CDK12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CDK12
        Cell Cycle / Checkpoint Control



    CDK12 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/588 Interacting proteins for CDK12 (Q9NYV42, 3 ENSP000003988804) via UniProtKB, MINT, STRING, and/or I2D (see all 588)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61865 MINT-7945693 I2D: score=5 
    SRRM2Q9UQ352, 3, ENSP000003017404MINT-7945693 I2D: score=1 STRING: ENSP00000301740
    POLR2AP249282, 3, ENSP000003149494MINT-7945693 I2D: score=2 STRING: ENSP00000314949
    SRSF1Q079552, 3, ENSP000002589624MINT-7945693 I2D: score=2 STRING: ENSP00000258962
    SRSF2Q011302, 3, ENSP000003508774MINT-7945693 I2D: score=2 STRING: ENSP00000350877
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing ISS--
    GO:0043405regulation of MAP kinase activity IMP19651820
    GO:0046777protein autophosphorylation IDA11683387
    GO:0070816phosphorylation of RNA polymerase II C-terminal domain IMP--


    CDK12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CDK12

    2 HMDB Compounds for CDK12    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Search CenterWatch for drugs/clinical trials and news about CDK12 

    Transcripts
    for CDK12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDK12 gene (2 alternative transcripts): 
    NM_015083.1  NM_016507.2  

    Unigene Cluster for CDK12:

    Cyclin-dependent kinase 12
    Hs.416108  [show with all ESTs]
    Unigene Representative Sequence: NM_016507
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000584632(uc010wef.1) ENST00000430627 ENST00000447079(uc010cvv.3 uc002hrw.4)
    ENST00000581593 ENST00000559663 ENST00000584336 ENST00000581963 ENST00000559545
    ENST00000585161 ENST00000558240

    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK12 (see all 55):
    hsa-miR-4328 hsa-miR-429 hsa-miR-330-5p hsa-miR-15a hsa-miR-30d hsa-miR-105 hsa-miR-30a hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: CDK12 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB020711.2 AF227198.1 AK302645.1 BC012428.1 BC140854.1 BC150265.1 

    13 DOTS entries:

    DT.407252  DT.97837995  DT.214006  DT.100716017  DT.120922935  DT.91889521  DT.95364481  DT.120922915 
    DT.120922953  DT.87014848  DT.91835016  DT.92434158  DT.99972837 

    24/199 AceView cDNA sequences (see all 199):

    AA480951 AI991518 AI123947 AA481122 AA742996 AI651579 AI308204 BM473746 
    AI350744 CD627982 BU167911 AA490255 AI128124 AI672119 AI081228 CR622325 
    CA454339 AW193787 BG390612 AI693362 AA420967 BE674496 AW593440 AA480893 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CDK12    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                                      -         
    SP2:                                                                                                


    ECgene alternative splicing isoforms for CDK12

    Expression
    for CDK12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCATATAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDK12 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyCap MesenchymeCap Mesenchyme CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CDK12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK12

    SOURCE GeneReport for Unigene cluster: Hs.416108

    UniProtKB/Swiss-Prot: CDK12_HUMAN, Q9NYV4
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for CDK12
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    In Situ
    Assay Products:     
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    Orthologs
    for CDK12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK12 gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDK121 cyclin-dependent kinase 12 75.59(n)
    78.76(a)    		   428306  XM_425866.3  XP_425866.3 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 73(a)
    60(a)
    		 1 ↔ many
    1 ↔ many
    		 6(67783549-67800200)
    6(67763234-67782997)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.153242 Xenopus laevis transcribed sequence with weak similarity more 74.01(n)    BJ069786.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1001498341 cdc2-related kinase, arginine/serine-rich-like 57.85(n)
    60.68(a)    		   100149834  XM_003200531.1  XP_003200579.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cdk126
    		 --
    		 32(a)
    		 1 → many
    		 3L(21509406-21515786)
    rice
    (Oryza sativa)    		 Liliopsida AK073808.12   -- 74.22(n)    AK073808.1 


    ENSEMBL Gene Tree for CDK12 (if available)
    TreeFam Gene Tree for CDK12 (if available) 

    Paralogs
    for CDK12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK12 gene
    CDK132  CDK92  
    18/66 SIMAP similar genes for CDK12 using alignment to 3 protein entries:     CDK12_HUMAN (see all proteins) (see all similar genes):
    PHKG2    CDKL2    MAP4K2    MAP4K5    CDC2    RPS6KA2
    TXK    CDK10    CDK1    CDK9    STK3    STK38L
    CDK7    DYRK4    NDUFA9    RPS6KA1    STK11    ULK1

    CDK12 for paralogs           About GeneDecksing



    Genomic Variants
    for CDK12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1226 NCBI SNPs in CDK12 are shown (see all 1226)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs728251931,2
    		C,--37615744(+) GTGGCC/TCACGC 2 -- us2k10--------
    rs728251941,2
    		C,F,--37616064(+) CCTGTG/CAGCAA 2 -- us2k12Minor allele frequency- C:0.04NA EA 240
    rs1422716721,2
    		--37616167(+) TCTCCA/GTTTTG 2 -- us2k10--------
    rs771133111,2
    		--37616239(+) CTGTTC/G/TTGAAG 2 -- us2k11NA 2
    rs1821661201,2
    		--37616266(+) TAGGCA/GAAAGT 2 -- us2k10--------
    rs46114921,2
    		C,F,H,--37616337(+) TACTAT/CGCTTT 2 -- us2k1 tfbs318Minor allele frequency- C:0.03NS EA NA 2240
    rs1407255951,2
    		--37616647(+) ATAATA/GTATGT 2 -- us2k10--------
    rs1870253861,2
    		--37616731(+) TGTCCC/TGACAT 2 -- us2k10--------
    rs1923749991,2
    		--37616962(+) GCGACC/TCTATA 2 -- us2k10--------
    rs129531781,2
    		C,F,--37617008(+) gcttgG/Agccca 2 -- us2k12Minor allele frequency- A:0.50NA 4

    HapMap Linkage Disequilibrium report for CDK12 (37617739 - 37721160 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for CDK12
         5 Indels: 11880 58790 45538 25828 11879

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    Disorders / Diseases
    for CDK12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDK12 for disorders           About GeneDecksing

    UniProtKB/Swiss-Prot: CDK12_HUMAN, Q9NYV4
  • Note=Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region
    • producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not
    in-frame with ERBB2

    2 diseases for CDK12:    About MalaCards
    gastric cancer    breast cancer

    Human Genome Epidemiology (HuGE) Navigator: CDK12 (0 documents)

    Export disorders for CDK12 gene to outside databases

    Publications
    for CDK12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK12 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with CDK12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. (PubMed id 11683387)1, 2, 3, 9 Ko T.K.... Pines J. (2001)
    2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    3. CDK12 is a transcription elongation-associated CTD ki nase, the metazoan ortholog of yeast Ctk1. (PubMed id 20952539)1, 2 Bartkowiak B....Greenleaf A.L. (2010)
    4. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    5. CRK7 modifies the MAPK pathway and influences the res ponse to endocrine therapy. (PubMed id 19651820)1, 2 Iorns E....Ashworth A. (2009)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)

    External Searches for CDK12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    NCBI Bookshelf
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    Genome Databases showing CDK12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51755 HGNC: 24224 AceView: CRK7 Ensembl:ENSG00000167258 euGenes: HUgn51755
    ECgene: CDK12 H-InvDB: CDK12

    Other Databases showing CDK12 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0904

    Specialized Databases showing CDK12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK12 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CDK12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDK12 gene:
    Search GeneIP for patents involving CDK12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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