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Aliases for CDK12 Gene

Aliases for CDK12 Gene

  • Cyclin Dependent Kinase 12 2 3 5
  • Cdc2-Related Kinase, Arginine/Serine-Rich 2 3 4
  • Cell Division Cycle 2-Related Protein Kinase 7 3 4
  • Cell Division Protein Kinase 12 3 4
  • CDC2-Related Protein Kinase 7 3 4
  • EC 2.7.11.22 4 61
  • CRKRS 3 4
  • CRK7 3 4
  • CDC2 Related Protein Kinase 7 2
  • Cyclin-Dependent Kinase 12 3
  • EC 2.7.11.23 4
  • EC 2.7.11 61
  • KIAA0904 4
  • HCDK12 4
  • CRKR 3

External Ids for CDK12 Gene

Previous HGNC Symbols for CDK12 Gene

  • CRKRS

Previous GeneCards Identifiers for CDK12 Gene

  • GC17P034873
  • GC17P037618
  • GC17P033411

Summaries for CDK12 Gene

GeneCards Summary for CDK12 Gene

CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and Formation of the HIV-1 Early Elongation Complex. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK13.

UniProtKB/Swiss-Prot for CDK12 Gene

  • Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates Ser-5 in CTD repeats that are already phosphorylated at Ser-7, but can also phosphorylate Ser-2. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Gene Wiki entry for CDK12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK12 Gene

Genomics for CDK12 Gene

Regulatory Elements for CDK12 Gene

Enhancers for CDK12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CDK12 on UCSC Golden Path with GeneCards custom track

Promoters for CDK12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CDK12 Gene

Chromosome:
17
Start:
39,461,486 bp from pter
End:
39,567,559 bp from pter
Size:
106,074 bases
Orientation:
Plus strand

Genomic View for CDK12 Gene

Genes around CDK12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK12 Gene

Proteins for CDK12 Gene

  • Protein details for CDK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYV4-CDK12_HUMAN
    Recommended name:
    Cyclin-dependent kinase 12
    Protein Accession:
    Q9NYV4
    Secondary Accessions:
    • A7E2B2
    • B4DYX4
    • B9EIQ6
    • O94978

    Protein attributes for CDK12 Gene

    Size:
    1490 amino acids
    Molecular mass:
    164155 Da
    Quaternary structure:
    • Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK.
    SequenceCaution:
    • Sequence=BAA74927.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK12 Gene

    Alternative splice isoforms for CDK12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK12 Gene

Post-translational modifications for CDK12 Gene

Other Protein References for CDK12 Gene

Domains & Families for CDK12 Gene

Gene Families for CDK12 Gene

Protein Domains for CDK12 Gene

Suggested Antigen Peptide Sequences for CDK12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYV4

UniProtKB/Swiss-Prot:

CDK12_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK12: view

Function for CDK12 Gene

Molecular function for CDK12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the ATP analog flavopiridol, purvalanol A, purvalanol B, staurosporine and CR8.
UniProtKB/Swiss-Prot Function:
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates Ser-5 in CTD repeats that are already phosphorylated at Ser-7, but can also phosphorylate Ser-2. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Enzyme Numbers (IUBMB) for CDK12 Gene

Gene Ontology (GO) - Molecular Function for CDK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 11683387
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 12841360
GO:0005524 ATP binding IEA --
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IMP 20952539
genes like me logo Genes that share ontologies with CDK12: view
genes like me logo Genes that share phenotypes with CDK12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK12 Gene

Localization for CDK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK12 Gene

Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK12 Gene COMPARTMENTS Subcellular localization image for CDK12 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CDK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002944 cyclin K-CDK12 complex IPI 22012619
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0016607 nuclear speck IEA,IDA 11683387
genes like me logo Genes that share ontologies with CDK12: view

Pathways & Interactions for CDK12 Gene

genes like me logo Genes that share pathways with CDK12: view

Pathways by source for CDK12 Gene

1 GeneTex pathway for CDK12 Gene
1 Cell Signaling Technology pathway for CDK12 Gene

SIGNOR curated interactions for CDK12 Gene

Activates:

Gene Ontology (GO) - Biological Process for CDK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA,ISS --
GO:0043405 regulation of MAP kinase activity IMP 19651820
GO:0043484 regulation of RNA splicing IEA --
GO:0046777 protein autophosphorylation IDA 11683387
genes like me logo Genes that share ontologies with CDK12: view

Drugs & Compounds for CDK12 Gene

(1) Drugs for CDK12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for CDK12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK12: view

Transcripts for CDK12 Gene

Unigene Clusters for CDK12 Gene

Cyclin-dependent kinase 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2:

Relevant External Links for CDK12 Gene

GeneLoc Exon Structure for
CDK12
ECgene alternative splicing isoforms for
CDK12

Expression for CDK12 Gene

mRNA expression in normal human tissues for CDK12 Gene

Protein differential expression in normal tissues from HIPED for CDK12 Gene

This gene is overexpressed in Liver (24.0), Peripheral blood mononuclear cells (11.7), and Lung (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDK12 Gene



Protein tissue co-expression partners for CDK12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK12 Gene:

CDK12

SOURCE GeneReport for Unigene cluster for CDK12 Gene:

Hs.416108

mRNA Expression by UniProt/SwissProt for CDK12 Gene:

Q9NYV4-CDK12_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with CDK12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK12 Gene

Orthologs for CDK12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDK12 34
  • 91.81 (n)
  • 93.49 (a)
CDK12 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK12 34
  • 93.28 (n)
  • 95.03 (a)
CDK12 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk12 34
  • 88.88 (n)
  • 90.63 (a)
Cdk12 16
Cdk12 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDK12 34
  • 98.48 (n)
  • 98.27 (a)
CDK12 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk12 34
  • 89.31 (n)
  • 91.24 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 87 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CDK12 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK12 34
  • 74.13 (n)
  • 76.84 (a)
CDK12 35
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 66 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk12 34
  • 66.92 (n)
  • 69.92 (a)
Str.18694 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15324 34
zebrafish
(Danio rerio)
Actinopterygii cdk12 35
  • 50 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cdk12 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdk-12 35
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 35
  • 37 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.21132 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10559 35
  • 57 (a)
OneToMany
Species where no ortholog for CDK12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDK12 Gene

ENSEMBL:
Gene Tree for CDK12 (if available)
TreeFam:
Gene Tree for CDK12 (if available)

Paralogs for CDK12 Gene

Paralogs for CDK12 Gene

genes like me logo Genes that share paralogs with CDK12: view

Variants for CDK12 Gene

Sequence variations from dbSNP and Humsavar for CDK12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs56121596 - 39,471,420(+) CTCTT(C/G/T)CCACA reference, missense
VAR_041969 A colorectal adenocarcinoma sample
rs56362165 - 39,526,122(+) GATCC(A/T)GCCTT reference, missense
rs34070318 - 39,530,667(+) ACCGC(C/T)GCCAC intron-variant, downstream-variant-500B, reference, missense
rs1054488 -- 39,531,715(+) GGGGG(A/G)TTGTG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDK12 Gene

Variant ID Type Subtype PubMed ID
dgv50n6 CNV deletion 16902084
esv1352810 CNV deletion 17803354
esv2263528 CNV deletion 18987734
esv2715901 CNV deletion 23290073
esv2715902 CNV deletion 23290073
esv2715903 CNV deletion 23290073
esv3554404 CNV deletion 23714750
nsv1063848 CNV gain 25217958
nsv1116009 CNV deletion 24896259
nsv1127568 CNV deletion 24896259
nsv1134648 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv1147003 CNV deletion 26484159
nsv1152691 CNV deletion 26484159
nsv819586 CNV gain 19587683
nsv827985 CNV loss 20364138
nsv955421 CNV deletion 24416366

Variation tolerance for CDK12 Gene

Residual Variation Intolerance Score: 1.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK12 Gene

Disorders for CDK12 Gene

UniProtKB/Swiss-Prot

CDK12_HUMAN
  • Note=Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.

Relevant External Links for CDK12

Human Genome Epidemiology (HuGE) Navigator
CDK12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK12

No disorders were found for CDK12 Gene.

No data available for MalaCards and Genatlas for CDK12 Gene

Publications for CDK12 Gene

  1. CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. (PMID: 11683387) Ko T.K. … Pines J. (J. Cell Sci. 2001) 2 3 4 22 65
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 65
  3. The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. (PMID: 22012619) Blazek D. … Peterlin B.M. (Genes Dev. 2011) 3 4 65
  4. CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. (PMID: 20952539) Bartkowiak B. … Greenleaf A.L. (Genes Dev. 2010) 3 4 65
  5. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3 65

Products for CDK12 Gene

Sources for CDK12 Gene

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