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Aliases for CDK12 Gene

Aliases for CDK12 Gene

  • Cyclin-Dependent Kinase 12 2 3 5
  • Cdc2-Related Kinase, Arginine/Serine-Rich 2 3 4
  • Cell Division Cycle 2-Related Protein Kinase 7 3 4
  • Cell Division Protein Kinase 12 3 4
  • CDC2-Related Protein Kinase 7 3 4
  • EC 2.7.11.22 4 63
  • CRKRS 3 4
  • CRK7 3 4
  • CDC2 Related Protein Kinase 7 2
  • EC 2.7.11.23 4
  • EC 2.7.11 63
  • KIAA0904 4
  • HCDK12 4
  • CRKR 3

External Ids for CDK12 Gene

Previous HGNC Symbols for CDK12 Gene

  • CRKRS

Previous GeneCards Identifiers for CDK12 Gene

  • GC17P034873
  • GC17P037618
  • GC17P033411

Summaries for CDK12 Gene

GeneCards Summary for CDK12 Gene

CDK12 (Cyclin-Dependent Kinase 12) is a Protein Coding gene. Diseases associated with CDK12 include ewing sarcoma. Among its related pathways are Gene Expression and Regulation of TP53 Activity. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK13.

UniProtKB/Swiss-Prot for CDK12 Gene

  • Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates Ser-5 in CTD repeats that are already phosphorylated at Ser-7, but can also phosphorylate Ser-2. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Gene Wiki entry for CDK12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK12 Gene

Genomics for CDK12 Gene

Regulatory Elements for CDK12 Gene

Promoters for CDK12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDK12 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDK12 Gene

Chromosome:
17
Start:
39,461,486 bp from pter
End:
39,567,559 bp from pter
Size:
106,074 bases
Orientation:
Plus strand

Genomic View for CDK12 Gene

Genes around CDK12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK12 Gene

Proteins for CDK12 Gene

  • Protein details for CDK12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYV4-CDK12_HUMAN
    Recommended name:
    Cyclin-dependent kinase 12
    Protein Accession:
    Q9NYV4
    Secondary Accessions:
    • A7E2B2
    • B4DYX4
    • B9EIQ6
    • O94978

    Protein attributes for CDK12 Gene

    Size:
    1490 amino acids
    Molecular mass:
    164155 Da
    Quaternary structure:
    • Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK.
    SequenceCaution:
    • Sequence=BAA74927.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK12 Gene

    Alternative splice isoforms for CDK12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK12 Gene

Proteomics data for CDK12 Gene at MOPED

Post-translational modifications for CDK12 Gene

Other Protein References for CDK12 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK12 (CDK12)

Domains & Families for CDK12 Gene

Gene Families for CDK12 Gene

Suggested Antigen Peptide Sequences for CDK12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYV4

UniProtKB/Swiss-Prot:

CDK12_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK12: view

Function for CDK12 Gene

Molecular function for CDK12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the ATP analog flavopiridol, purvalanol A, purvalanol B, staurosporine and CR8.
UniProtKB/Swiss-Prot Function:
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates Ser-5 in CTD repeats that are already phosphorylated at Ser-7, but can also phosphorylate Ser-2. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Enzyme Numbers (IUBMB) for CDK12 Gene

Gene Ontology (GO) - Molecular Function for CDK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,IDA 11683387
genes like me logo Genes that share ontologies with CDK12: view
genes like me logo Genes that share phenotypes with CDK12: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK12 Gene

Localization for CDK12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK12 Gene

Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK12 Gene COMPARTMENTS Subcellular localization image for CDK12 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CDK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with CDK12: view

Pathways & Interactions for CDK12 Gene

genes like me logo Genes that share pathways with CDK12: view

Pathways by source for CDK12 Gene

SIGNOR curated interactions for CDK12 Gene

Activates:

Gene Ontology (GO) - Biological Process for CDK12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043484 regulation of RNA splicing IEA --
GO:0046777 protein autophosphorylation IDA 11683387
GO:0051726 regulation of cell cycle IEA --
genes like me logo Genes that share ontologies with CDK12: view

Drugs & Compounds for CDK12 Gene

(1) Drugs for CDK12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for CDK12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK12: view

Transcripts for CDK12 Gene

Unigene Clusters for CDK12 Gene

Cyclin-dependent kinase 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2:

Relevant External Links for CDK12 Gene

GeneLoc Exon Structure for
CDK12
ECgene alternative splicing isoforms for
CDK12

Expression for CDK12 Gene

mRNA expression in normal human tissues for CDK12 Gene

Protein differential expression in normal tissues from HIPED for CDK12 Gene

This gene is overexpressed in Liver (24.0), Peripheral blood mononuclear cells (11.7), and Lung (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDK12 Gene



SOURCE GeneReport for Unigene cluster for CDK12 Gene Hs.416108

mRNA Expression by UniProt/SwissProt for CDK12 Gene

Q9NYV4-CDK12_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with CDK12: view

Protein tissue co-expression partners for CDK12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK12 Gene

Orthologs for CDK12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK12 35
  • 98.48 (n)
  • 98.27 (a)
CDK12 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK12 36
  • 94 (a)
OneToOne
CDK12 35
  • 91.81 (n)
  • 93.49 (a)
dog
(Canis familiaris)
Mammalia CDK12 35
  • 93.28 (n)
  • 95.03 (a)
CDK12 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk12 16
Cdk12 35
  • 88.88 (n)
  • 90.63 (a)
Cdk12 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CDK12 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk12 35
  • 89.31 (n)
  • 91.24 (a)
chicken
(Gallus gallus)
Aves CDK12 36
  • 79 (a)
OneToOne
CDK12 35
  • 74.13 (n)
  • 76.84 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.15324 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk12 35
  • 66.92 (n)
  • 69.92 (a)
Str.18694 35
zebrafish
(Danio rerio)
Actinopterygii cdk12 36
  • 50 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cdk12 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdk-12 36
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 36
  • 37 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.21132 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10559 36
  • 57 (a)
OneToMany
Species with no ortholog for CDK12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDK12 Gene

ENSEMBL:
Gene Tree for CDK12 (if available)
TreeFam:
Gene Tree for CDK12 (if available)

Paralogs for CDK12 Gene

Paralogs for CDK12 Gene

genes like me logo Genes that share paralogs with CDK12: view

Variants for CDK12 Gene

Sequence variations from dbSNP and Humsavar for CDK12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs56121596 - 39,471,420(+) CTCTT(C/G/T)CCACA reference, missense
VAR_041969 A colorectal adenocarcinoma sample
rs56362165 - 39,526,122(+) GATCC(A/T)GCCTT reference, missense
rs34070318 - 39,530,667(+) ACCGC(C/T)GCCAC intron-variant, downstream-variant-500B, reference, missense
rs1077715 -- 39,527,295(-) CGGCA(A/T)CTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK12 Gene

Variant ID Type Subtype PubMed ID
nsv908204 CNV Gain 21882294
nsv827985 CNV Loss 20364138
esv2715901 CNV Deletion 23290073
esv2263528 CNV Deletion 18987734
esv2715902 CNV Deletion 23290073
esv1352810 CNV Deletion 17803354
dgv50n6 CNV Loss 16902084
esv2715903 CNV Deletion 23290073
nsv819586 CNV Gain 19587683

Variation tolerance for CDK12 Gene

Residual Variation Intolerance Score: 1.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK12 Gene

HapMap Linkage Disequilibrium report
CDK12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK12 Gene

Disorders for CDK12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK12 Gene - From: GeneTests

Disorder Aliases PubMed IDs
ewing sarcoma
  • neuroepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search CDK12 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDK12_HUMAN
  • Note=Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.

Relevant External Links for CDK12

Human Genome Epidemiology (HuGE) Navigator
CDK12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK12
genes like me logo Genes that share disorders with CDK12: view

No data available for Genatlas for CDK12 Gene

Publications for CDK12 Gene

  1. CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles. (PMID: 11683387) Ko T.K. … Pines J. (J. Cell Sci. 2001) 2 3 4 23 67
  2. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CDK12 Gene

Sources for CDK12 Gene

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