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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK11B Gene

protein-coding   GIFtS: 57
GCID: GC01M001574

Cyclin-Dependent Kinase 11B

(Previous name: cell division cycle 2-like 1 (PITSLRE proteins))
(Previous symbol: CDC2L1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cyclin-Dependent Kinase 11B1 2     PITSLRE Serine/Threonine-Protein Kinase CDC2L12 3
CDC2L11 2 3 5     EC 2.7.11.223 8
CDK112 3 5     CDK11-p1102
Cell Division Cycle 2-Like 1 (PITSLRE Proteins)1 2     CDK11-p462
Cell Division Cycle 2-Like Protein Kinase 12 3     CDK11-p582
Cell Division Protein Kinase 11B2 3     CDC-Related Protein Kinase P582
Galactosyltransferase-Associated Protein Kinase P58/GTA2 3     p582
CLK-12 3     p58CDC2L12
PITSLREA2 3     p58CLK-12
PK582 3     P585
P58 CLK-12 3     EC 2.7.118

External Ids:    HGNC: 17291   Entrez Gene: 9842   Ensembl: ENSG000002483337   OMIM: 1768735   UniProtKB: P211273   

Export aliases for CDK11B gene to outside databases

Previous GC identifers: GC01M001628 GC01M001572


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK11B Gene:
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be
essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene
in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22,
consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region
that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma
with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was
demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been
reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDK11B Gene: 
CDK11B (cyclin-dependent kinase 11B) is a protein-coding gene. Diseases associated with CDK11B include childhood endodermal sinus tumor, and endodermal sinus tumor, and among its related super-pathways are G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK20.

UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127
Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms
have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein
SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression

Gene Wiki entry for CDK11B (CDC2L1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004350.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK11B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CDK11B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK11B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

CDK11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK11B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001574:  view genomic region     (about GC identifiers)

Start:
1,570,603 bp from pter      End:
1,590,473 bp from pter
Size:
19,871 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 11B  
Size: 795 amino acids; 92707 Da
Cofactor: Magnesium
Subunit: The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts
with RNPS1. The p58 isoform but not the p110 isoforms or p110C interacts with CCND3. The p110 isoforms are found
in large molecular weight complexes containing CCNL1 and SFRS7
Subcellular location: Cytoplasm. Nucleus
Miscellaneous: Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain
at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated
alternative initiation of translation
Caution: Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B
or one/some of the isoforms of each
Sequence caution: Sequence=AAC83664.1; Type=Erroneous gene model prediction; Sequence=AAF36538.1; Type=Erroneous
initiation;
Secondary accessions: O95265 Q12817 Q12818 Q12819 Q12820 Q12822 Q8N530 Q9NZS5 Q9UBJ0 Q9UBQ1
Q9UBR0 Q9UNY2 Q9UP57 Q9UP58 Q9UP59
Alternative splicing, Alternative initiation: 10 isoforms:  P21127-1   P21127-2   P21127-3   P21127-4   P21127-5   P21127-6   P21127-8   P21127-9   
P21127-10   P21127-12   (Produced by alternative initiation at Met-357 of isoform SV9)

Explore the universe of human proteins at neXtProt for CDK11B: NX_P21127

Explore proteomics data for CDK11B at MOPED 

Post-translational modifications:

  • UniProtKB: During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to
    produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins
  • UniProtKB: Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P21127

  • 4/13 DME Specific Peptides for CDK11B (P21127) (see all 13)
     VKRGTSP  ILHRDLK  EQLERKR  VVTLWYR 

    CDK11B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK11B Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_277021.1  NP_277022.1  NP_277023.1  NP_277024.1  NP_277027.1  NP_277028.1  

    ENSEMBL proteins: 
     ENSP00000463404   ENSP00000344418   ENSP00000464036   ENSP00000463200   ENSP00000464016  
     ENSP00000463048  
    Reactome Protein details: P21127
    Human Recombinant Protein Products for CDK11B: 
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    Cloud-Clone Corp. Proteins for CDK11B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    CDK11B for ontologies           About GeneDecksing



    CDK11B Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 11B 
    PITSLRE subfamily

    4 InterPro protein domains:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P21127

    ProtoNet protein and cluster: P21127

    UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK11B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD11B_HUMAN, P21127
    Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms
    have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein
    SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595
    activates it (By similarity)
    Induction: The p58 isoform is specifically induced in G2/M phase of the cell cycle

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS1639388
    GO:0004674protein serine/threonine kinase activity IDA12501247
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12624090
         
    CDK11B for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for CDK11B:
     Decreased substrate adherent c  Decreased viability  Increased apoptosis  Increased circadian period len 
     Increased viability with 4OH t  Weaker migration 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cdk11b):
     cellular  embryogenesis  integument  mortality/aging  tumorigenesis 

    CDK11B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdk11btm1Vjk for CDK11B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK11B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK11B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK11B 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK11B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    G2/M Transition0.83
    Centrosome maturation0.83
    Mitotic G2-G2/M phases0.81
    2Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    3DNA Damage
    Cell Cycle / Checkpoint Control0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CDK11B
        Cell Cycle / Checkpoint Control

    5/6        Reactome Pathways for CDK11B (see all 6)
        Centrosome maturation
    G2/M Transition
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    Mitotic G2-G2/M phases



    CDK11B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK11B

    5/24 Interacting proteins for CDK11B (P211271, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAK1Q131531, 2, 3EBI-1298,EBI-1307 MINT-1771821 I2D: score=3 
    KAT7O952512, 3MINT-62237 MINT-62238 MINT-62239 MINT-62236 MINT-62240 MINT-62241 I2D: score=2 
    EIF3FO003032, 3MINT-6948862 MINT-6948836 MINT-6948849 I2D: score=1 
    URM1Q9BTM92, 3MINT-63553 I2D: score=3 
    CCND3P302813I2D: score=2 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEP10882096
    GO:0001824blastocyst development ----
    GO:0006355regulation of transcription, DNA-dependent NAS9750192
    GO:0006468protein phosphorylation IDA12501247
    GO:0006915apoptotic process NAS9750192

    CDK11B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK11B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CDK11B

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    3 HMDB Compounds for CDK11B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about CDK11B / CD11B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK11B gene (8 alternative transcripts): 
    NM_033486.1  NM_033487.1  NM_033488.1  NM_033489.1  NM_033492.1  NM_033493.1  NM_001787.1  NM_033490.1  

    Unigene Cluster for CDK11B:

    Cyclin-dependent kinase 11B
    Hs.709182  [show with all ESTs]
    Unigene Representative Sequence: AK000081
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513088 ENST00000341028(uc001ahc.1) ENST00000407249 ENST00000317673
    ENST00000340677 ENST00000341832(uc009vkj.2 uc010nyr.1 uc001ags.1 uc001agt.1 uc001aha.1 uc001agw.1 uc001agv.1 uc001agy.1 uc001agx.1 uc001agz.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AF067512.1 AF067513.1 AF067514.1 AF067515.1 AF067516.1 AF174497.1 AK000081.1 AK295607.1 
    AK301495.1 AK303446.1 AK303451.1 AK304679.1 BC009375.2 BC062579.1 BC139777.1 BC140714.1 
    BC171773.1 U04816.1 U04817.1 U04818.1 U04824.1 

    24/32 DOTS entries (see all 32):

    DT.40308783  DT.92453672  DT.95224500  DT.75133401  DT.92453679  DT.92453688  DT.100887081  DT.91946997 
    DT.100887093  DT.100887090  DT.121399105  DT.121399199  DT.100887079  DT.100887091  DT.99977005  DT.121399213 
    DT.121643403  DT.92453670  DT.100044908  DT.40105999  DT.40223002  DT.101985235  DT.92453681  DT.95224492 

    24/499 AceView cDNA sequences (see all 499):

    NM_182838 BC014464 CR617963 AW027583 CR619853 AL519809 AI066775 CR591109 
    AA159745 BE674770 BI753229 CR600892 BM661926 AW662168 CR612504 AL049665 
    CB148088 BM679566 AI374934 CK429285 AA761922 AW072757 AL043340 CB159795 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK11B expression in normal human tissues (normalized intensities)      CDK11B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDK11B Expression
    About this image


    CDK11B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/midbrain   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Neural Tube (Nervous System)
             Telencephalon

    See CDK11B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK11B

    SOURCE GeneReport for Unigene cluster: Hs.709182

    UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127
    Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK11B gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk11b1 , 5 cyclin-dependent kinase 11B1, 5 87.43(n)1
    96.93(a)1
      4 (86.73 cM)5
    125371  NM_007661.31  NP_031687.21 
     1556248545 
    chicken
    (Gallus gallus)
    Aves CDC2L11 cell division cycle 2-like 1 (PITSLRE proteins) 77.94(n)
    93.37(a)
      419406  NM_001030871.2  NP_001026042.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    93(a)
    1 → many
    GL344966.1(22-14045)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238882 Xenopus laevis transcribed sequence with strong similarity more 76.01(n)    BU916896.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA472942.12   -- 83.33(n)    CA472942.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pitslre1 CG4268-PA 53.27(n)
    49.51(a)
      40292  NM_168869.2  NP_730563.1 
    worm
    (Caenorhabditis elegans)
    Secernentea B0495.21 Protein B0495.2 47.65(n)
    42.25(a)
      174244  NM_063216.4  NP_495617.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTK16
    Catalytic (alpha) subunit of C-terminal domain kin...
    26(a)
    1 → many
    XI(182958-184544)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G675801 protein kinase-like protein 55.51(n)
    57.05(a)
      843079  NM_105425.4  NP_176925.1 
    rice
    (Oryza sativa)
    Liliopsida Os.118892 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.42(n)    AK111593.1 


    ENSEMBL Gene Tree for CDK11B (if available)
    TreeFam Gene Tree for CDK11B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK11B gene
    CDK11A1 2  CDK202  CDK102  CDK72  
    18/59 SIMAP similar genes for CDK11B using alignment to 6 protein entries:     CD11B_HUMAN (see all proteins) (see all similar genes):
    CDC2L2    CDC2L1    CDK11A    DYRK4    NDUFA9    CDK10
    CDC2    PHKG2    CDK1    CDK3    CDK5    CDK6
    DKFZp686L20222    NEK9    CDK2    CDK7    CDK9    CDK4

    CDK11B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CDK11B
    PGOHUM00000247147


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/466 SNPs in CDK11B are shown (see all 466)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419584
    ----see VAR_0419582 R C mis40--------
    VAR_0419614
    ----see VAR_0419612 I V mis40--------
    VAR_0455774
    ----see VAR_0455772 V A mis40--------
    VAR_0419624
    ----see VAR_0419622 L Q mis40--------
    VAR_0455784
    ----see VAR_0455782 G S mis40--------
    VAR_0419644
    ----see VAR_0419642 A V mis40--------
    VAR_0621994
    ----see VAR_0621992 R C mis40--------
    VAR_0419594
    ----see VAR_0419592 R W mis40--------
    VAR_0577754
    ----see VAR_0577752 R W mis40--------
    VAR_0419604
    ----see VAR_0419602 S L mis40--------

    HapMap Linkage Disequilibrium report for CDK11B (1570603 - 1590473 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/66 variations for CDK11B (see all 66):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677252CNV Deletion23128226
    esv1758309CNV Deletion17803354
    esv2749696CNV Deletion23290073
    dgv3e201CNV Deletion23290073
    esv2748807CNV Deletion23290073
    esv2748696CNV Deletion23290073
    esv2748918CNV Deletion23290073
    esv1455500CNV Deletion17803354
    dgv4e201CNV Deletion23290073
    dgv2e199CNV Deletion23128226

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176873    OMIM disorders: --

    11 diseases for CDK11B:    About MalaCards
    childhood endodermal sinus tumor    endodermal sinus tumor    sinusitis    neuroblastoma
    keloids    hodgkin's lymphoma    non-hodgkin lymphoma    melanoma
    alzheimer's disease    hepatocellular carcinoma    breast cancer


    CDK11B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for CDK11B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 19.5 2 15344906 (1)
    tumors 0 1 9162192 (1)

    Genetic Association Database (GAD): CDK11B
    Human Genome Epidemiology (HuGE) Navigator: CDK11B (1 document)

    Export disorders for CDK11B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK11B gene, integrated from 9 sources (see all 81):
    (articles sorted by number of sources associating them with CDK11B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. (PubMed id 14511641)1, 2, 3 Mikolajczyk M.... Nelson M. (2003)
    2. CDK11 complexes promote pre-mRNA splicing. (PubMed id 12501247)1, 2, 9 Hu D.... Kidd V.J. (2003)
    3. Structure and expression of the human p58clk-1 protein kinase chromosomal gene. (PubMed id 1639388)1, 2, 9 Eipers P.G.... Kidd V.J. (1992)
    4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    5. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. The cyclin-dependent kinase 11 interacts with 14-3-3 proteins. (PubMed id 15883043)1, 2 Feng Y....Nelson M.A. (2005)
    9. The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. (PubMed id 12624090)1, 2 Chen S.... Gu J. (2003)
    10. Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. (PubMed id 10882096)1, 2 Cornelis S....Beyaert R. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 984 HGNC: 1729 AceView: CDC2L1andSLC35E2 Ensembl:ENSG00000248333 euGenes: HUgn984
    ECgene: CDK11B H-InvDB: CDK11B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK11B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK11B gene:
    Search GeneIP for patents involving CDK11B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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