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Aliases for CDK11B Gene

Aliases for CDK11B Gene

  • Cyclin Dependent Kinase 11B 2 3 5
  • Galactosyltransferase-Associated Protein Kinase P58/GTA 3 4
  • Cell Division Cycle 2-Like 1 (PITSLRE Proteins) 2 3
  • PITSLRE Serine/Threonine-Protein Kinase CDC2L1 3 4
  • Cell Division Protein Kinase 11B 3 4
  • EC 2.7.11.22 4 61
  • P58 CLK-1 3 4
  • PITSLREA 3 4
  • CDC2L1 3 4
  • CDK11 3 4
  • CLK-1 3 4
  • PK58 3 4
  • Cell Division Cycle 2-Like Protein Kinase 1 4
  • CDC-Related Protein Kinase P58 3
  • Cyclin-Dependent Kinase 11B 3
  • CDK11-P110 3
  • CDK11-P46 3
  • CDK11-P58 3
  • P58CDC2L1 3
  • EC 2.7.11 61
  • P58CLK-1 3
  • P58 3

External Ids for CDK11B Gene

Previous HGNC Symbols for CDK11B Gene

  • CDC2L1

Previous GeneCards Identifiers for CDK11B Gene

  • GC01M001628
  • GC01M001572
  • GC01M001574

Summaries for CDK11B Gene

Entrez Gene Summary for CDK11B Gene

  • This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CDK11B Gene

CDK11B (Cyclin Dependent Kinase 11B) is a Protein Coding gene. Diseases associated with CDK11B include Neuroblastoma. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is CDK11A.

UniProtKB/Swiss-Prot for CDK11B Gene

  • Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.

Gene Wiki entry for CDK11B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK11B Gene

Genomics for CDK11B Gene

Regulatory Elements for CDK11B Gene

Enhancers for CDK11B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CDK11B on UCSC Golden Path with GeneCards custom track

Promoters for CDK11B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CDK11B Gene

Chromosome:
1
Start:
1,635,226 bp from pter
End:
1,659,839 bp from pter
Size:
24,614 bases
Orientation:
Minus strand

Genomic View for CDK11B Gene

Genes around CDK11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK11B Gene

Proteins for CDK11B Gene

  • Protein details for CDK11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21127-CD11B_HUMAN
    Recommended name:
    Cyclin-dependent kinase 11B
    Protein Accession:
    P21127
    Secondary Accessions:
    • O95265
    • Q12817
    • Q12818
    • Q12819
    • Q12820
    • Q12822
    • Q8N530
    • Q9NZS5
    • Q9UBJ0
    • Q9UBQ1
    • Q9UBR0
    • Q9UNY2
    • Q9UP57
    • Q9UP58
    • Q9UP59

    Protein attributes for CDK11B Gene

    Size:
    795 amino acids
    Molecular mass:
    92707 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Cleaved isoform SV9 (p110C) binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. Isoform 7, but not isoform SV9, nor its cleavage product p110C, interacts with CCND3. Interacts with CCNL1 and CCNL2. Forms complexes with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7.
    Miscellaneous:
    • Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.
    SequenceCaution:
    • Sequence=AAC83664.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAF36538.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK11B Gene

neXtProt entry for CDK11B Gene

Post-translational modifications for CDK11B Gene

  • During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.
  • Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.
  • Ubiquitination at Lys 660
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK11B (CDK11B)

Domains & Families for CDK11B Gene

Gene Families for CDK11B Gene

Protein Domains for CDK11B Gene

Suggested Antigen Peptide Sequences for CDK11B Gene

Graphical View of Domain Structure for InterPro Entry

P21127

UniProtKB/Swiss-Prot:

CD11B_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK11B: view

Function for CDK11B Gene

Molecular function for CDK11B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595 activates it.
UniProtKB/Swiss-Prot Function:
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
UniProtKB/Swiss-Prot Induction:
Isoform 7 is induced in G2/M phase of the cell cycle.

Enzyme Numbers (IUBMB) for CDK11B Gene

Gene Ontology (GO) - Molecular Function for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 1639388
GO:0004674 protein serine/threonine kinase activity IDA 12501247
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 12624090
GO:0005524 ATP binding IDA 12501247
genes like me logo Genes that share ontologies with CDK11B: view
genes like me logo Genes that share phenotypes with CDK11B: view

Human Phenotype Ontology for CDK11B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDK11B Gene

Localization for CDK11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK11B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK11B Gene COMPARTMENTS Subcellular localization image for CDK11B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8195233
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDK11B: view

Pathways & Interactions for CDK11B Gene

genes like me logo Genes that share pathways with CDK11B: view

Pathways by source for CDK11B Gene

1 GeneTex pathway for CDK11B Gene
1 Cell Signaling Technology pathway for CDK11B Gene

SIGNOR curated interactions for CDK11B Gene

Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEP 10882096
GO:0006355 regulation of transcription, DNA-templated NAS 9750192
GO:0006468 protein phosphorylation IDA 12501247
GO:0006915 apoptotic process NAS 9750192
GO:0007067 mitotic nuclear division NAS 1639388
genes like me logo Genes that share ontologies with CDK11B: view

Drugs & Compounds for CDK11B Gene

(2) Drugs for CDK11B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for CDK11B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK11B: view

Transcripts for CDK11B Gene

Unigene Clusters for CDK11B Gene

Cyclin-dependent kinase 11B:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK11B Gene

No ASD Table

Relevant External Links for CDK11B Gene

GeneLoc Exon Structure for
CDK11B
ECgene alternative splicing isoforms for
CDK11B

Expression for CDK11B Gene

mRNA expression in normal human tissues for CDK11B Gene

Protein differential expression in normal tissues from HIPED for CDK11B Gene

This gene is overexpressed in Pancreas (20.4), Lung (15.0), Testis (8.5), and Ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK11B Gene



Protein tissue co-expression partners for CDK11B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK11B Gene:

CDK11B

SOURCE GeneReport for Unigene cluster for CDK11B Gene:

Hs.709182

mRNA Expression by UniProt/SwissProt for CDK11B Gene:

P21127-CD11B_HUMAN
Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
genes like me logo Genes that share expression patterns with CDK11B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK11B Gene

Orthologs for CDK11B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK11B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC2L1 35
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cdk11b 35
  • 88 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 88 (a)
OneToMany
chicken
(Gallus gallus)
Aves CDC2L1 35
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 93 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16205 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23888 34
zebrafish
(Danio rerio)
Actinopterygii cdk11b 35
  • 87 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pitslre 35
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.2 35
  • 40 (a)
ManyToMany
ZC504.3 35
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 35
  • 27 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.11311 34
barley
(Hordeum vulgare)
Liliopsida Hv.6051 34
rice
(Oryza sativa)
Liliopsida Os.11889 34
wheat
(Triticum aestivum)
Liliopsida Ta.4787 34
Species where no ortholog for CDK11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDK11B Gene

ENSEMBL:
Gene Tree for CDK11B (if available)
TreeFam:
Gene Tree for CDK11B (if available)

Paralogs for CDK11B Gene

Paralogs for CDK11B Gene

Pseudogenes.org Pseudogenes for CDK11B Gene

genes like me logo Genes that share paralogs with CDK11B: view

Variants for CDK11B Gene

Sequence variations from dbSNP and Humsavar for CDK11B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_041958 -
VAR_041959 -
VAR_041960 -
VAR_041961 -
VAR_041962 -

Structural Variations from Database of Genomic Variants (DGV) for CDK11B Gene

Variant ID Type Subtype PubMed ID
dgv2e199 CNV deletion 23128226
dgv3n67 CNV gain 20364138
dgv5n111 CNV deletion 26073780
dgv8n100 CNV loss 25217958
esv1336011 CNV insertion 17803354
esv2661270 CNV deletion 23128226
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv27786 CNV gain 19812545
esv3390461 CNV duplication 20981092
esv3550788 CNV deletion 23714750
esv3575582 CNV gain 25503493
esv3585007 CNV loss 21293372
nsv10161 CNV gain+loss 18304495
nsv1073627 CNV deletion 25765185
nsv1075361 CNV duplication 25765185
nsv1118425 CNV duplication 24896259
nsv1139466 CNV duplication 24896259
nsv1160797 CNV duplication 26073780
nsv482937 CNV loss 15286789
nsv545017 CNV loss 21841781
nsv545018 CNV loss 21841781
nsv947410 CNV duplication 23825009
nsv950452 CNV deletion 24416366

Variation tolerance for CDK11B Gene

Gene Damage Index Score: 2.65; 45.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK11B Gene

Disorders for CDK11B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK11B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDK11B

Genetic Association Database (GAD)
CDK11B
Human Genome Epidemiology (HuGE) Navigator
CDK11B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK11B
genes like me logo Genes that share disorders with CDK11B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK11B Gene

Publications for CDK11B Gene

  1. The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. (PMID: 14511641) Mikolajczyk M. … Nelson M. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 65
  2. CDK11 complexes promote pre-mRNA splicing. (PMID: 12501247) Hu D. … Kidd V.J. (J. Biol. Chem. 2003) 3 4 22 65
  3. Structure and expression of the human p58clk-1 protein kinase chromosomal gene. (PMID: 1639388) Eipers P.G. … Kidd V.J. (Genomics 1992) 3 4 22 65
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 65
  5. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3 65

Products for CDK11B Gene

Sources for CDK11B Gene

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