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Aliases for CDK11B Gene

Aliases for CDK11B Gene

  • Cyclin Dependent Kinase 11B 2 3 5
  • Galactosyltransferase-Associated Protein Kinase P58/GTA 3 4
  • Cell Division Cycle 2-Like 1 (PITSLRE Proteins) 2 3
  • PITSLRE Serine/Threonine-Protein Kinase CDC2L1 3 4
  • Cell Division Protein Kinase 11B 3 4
  • EC 4 58
  • P58 CLK-1 3 4
  • PITSLREA 3 4
  • CDC2L1 3 4
  • CDK11 3 4
  • CLK-1 3 4
  • PK58 3 4
  • Cell Division Cycle 2-Like Protein Kinase 1 4
  • CDC-Related Protein Kinase P58 3
  • Cyclin-Dependent Kinase 11B 3
  • CDK11-P110 3
  • CDK11-P46 3
  • CDK11-P58 3
  • P58CDC2L1 3
  • EC 2.7.11 58
  • P58CLK-1 3
  • P58 3

External Ids for CDK11B Gene

Previous HGNC Symbols for CDK11B Gene

  • CDC2L1

Previous GeneCards Identifiers for CDK11B Gene

  • GC01M001628
  • GC01M001572
  • GC01M001574
  • GC01M001636
  • GC01M001637
  • GC01M001641

Summaries for CDK11B Gene

Entrez Gene Summary for CDK11B Gene

  • This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CDK11B Gene

CDK11B (Cyclin Dependent Kinase 11B) is a Protein Coding gene. Diseases associated with CDK11B include Neuroblastoma. Among its related pathways are DNA Damage and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is CDK11A.

UniProtKB/Swiss-Prot for CDK11B Gene

  • Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.

Gene Wiki entry for CDK11B Gene

Additional gene information for CDK11B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK11B Gene

Genomics for CDK11B Gene

Regulatory Elements for CDK11B Gene

Enhancers for CDK11B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H001269 1.6 Ensembl ENCODE dbSUPER 25.1 +387.3 387348 5.5 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 ZNF207 ZNF143 SP3 ENSG00000230092 CDK11A UBE2J2 ENSG00000237094 INTS11 LOC100288069 LOC100288379 ATAD3B CDK11B CCNL2
GH01H001397 1.2 ENCODE 24.4 +259.7 259726 5.5 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SSRP1 ZNF610 INTS11 ATAD3B ENSG00000240731 CCNL2 ENSG00000230092 SLC35E2 NOC2L LOC100129381 LOC100288379 CDK11B
GH01H002253 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.9 -596.6 -596553 6.4 PKNOX1 ATF1 ARNT BRCA1 ZNF2 ETS1 TCF12 GLIS2 CBX5 FOS ATAD3B CCNL2 ENSG00000240731 INTS11 CDK11A UBE2J2 RER1 CDK11B SLC35E2 LOC100288379
GH01H002045 1.6 FANTOM5 ENCODE dbSUPER 14 -390.2 -390226 8.8 MLX ARID4B DMAP1 YY1 ZNF121 GLIS2 ZNF143 FOS ATF7 SP3 UBE2J2 CDK11B CDK11A INTS11 PRKCZ ENSG00000271806 ANKRD65 FNDC10 SLC35E2B NADK
GH01H001196 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +459.0 458977 8 ATF1 ZNF766 GLIS2 ZNF143 FOS ATF7 RUNX3 ZNF202 ZNF592 ZSCAN16 ATAD3B INTS11 SDF4 CCNL2 NOC2L ENSG00000230092 ENSG00000240731 CDK11A LOC100288379 UBE2J2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDK11B on UCSC Golden Path with GeneCards custom track

Promoters for CDK11B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000215 839 1601 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 SP3 ZHX2

Genomic Locations for CDK11B Gene

Genomic Locations for CDK11B Gene
24,614 bases
Minus strand

Genomic View for CDK11B Gene

Genes around CDK11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK11B Gene

Proteins for CDK11B Gene

  • Protein details for CDK11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase 11B
    Protein Accession:
    Secondary Accessions:
    • O95265
    • Q12817
    • Q12818
    • Q12819
    • Q12820
    • Q12822
    • Q8N530
    • Q9NZS5
    • Q9UBJ0
    • Q9UBQ1
    • Q9UBR0
    • Q9UNY2
    • Q9UP57
    • Q9UP58
    • Q9UP59

    Protein attributes for CDK11B Gene

    795 amino acids
    Molecular mass:
    92707 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Cleaved isoform SV9 (p110C) binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. Isoform 7, but not isoform SV9, nor its cleavage product p110C, interacts with CCND3. Interacts with CCNL1 and CCNL2. Forms complexes with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7. Interacts with isoform 5 of MYO18A (PubMed:25965346).
    • Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.
    • Sequence=AAC83664.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAF36538.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK11B Gene

neXtProt entry for CDK11B Gene

Selected DME Specific Peptides for CDK11B Gene


Post-translational modifications for CDK11B Gene

  • During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.
  • Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.
  • Ubiquitination at Lys660
  • Modification sites at PhosphoSitePlus

Domains & Families for CDK11B Gene

Gene Families for CDK11B Gene

Protein Domains for CDK11B Gene

Suggested Antigen Peptide Sequences for CDK11B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK11B: view

Function for CDK11B Gene

Molecular function for CDK11B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595 activates it.
UniProtKB/Swiss-Prot Function:
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.
UniProtKB/Swiss-Prot Induction:
Isoform 7 is induced in G2/M phase of the cell cycle.

Enzyme Numbers (IUBMB) for CDK11B Gene

Phenotypes From GWAS Catalog for CDK11B Gene

Gene Ontology (GO) - Molecular Function for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0004672 protein kinase activity TAS 1639388
GO:0004674 protein serine/threonine kinase activity IDA 12501247
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI 12624090
genes like me logo Genes that share ontologies with CDK11B: view
genes like me logo Genes that share phenotypes with CDK11B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDK11B Gene

Localization for CDK11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK11B Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK11B gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8195233
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDK11B: view

Pathways & Interactions for CDK11B Gene

genes like me logo Genes that share pathways with CDK11B: view

Pathways by source for CDK11B Gene

1 GeneTex pathway for CDK11B Gene
1 Cell Signaling Technology pathway for CDK11B Gene

SIGNOR curated interactions for CDK11B Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle NAS 1639388
GO:0001558 regulation of cell growth IEP 10882096
GO:0006355 regulation of transcription, DNA-templated NAS 9750192
GO:0006468 protein phosphorylation IDA,IEA 12501247
GO:0006915 apoptotic process NAS 9750192
genes like me logo Genes that share ontologies with CDK11B: view

Drugs & Compounds for CDK11B Gene

(2) Drugs for CDK11B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Nutra Agonist 0
Magnesium Nutra 0

(1) Additional Compounds for CDK11B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK11B: view

Transcripts for CDK11B Gene

Unigene Clusters for CDK11B Gene

Cyclin-dependent kinase 11B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK11B Gene

No ASD Table

Relevant External Links for CDK11B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDK11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDK11B Gene

Protein differential expression in normal tissues from HIPED for CDK11B Gene

This gene is overexpressed in Pancreas (20.4), Lung (15.0), Testis (8.5), and Ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDK11B Gene

Protein tissue co-expression partners for CDK11B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDK11B Gene:


SOURCE GeneReport for Unigene cluster for CDK11B Gene:


mRNA Expression by UniProt/SwissProt for CDK11B Gene:

Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.

Evidence on tissue expression from TISSUES for CDK11B Gene

  • Blood(4)
  • Liver(4)
genes like me logo Genes that share expression patterns with CDK11B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDK11B Gene

Orthologs for CDK11B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK11B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDC2L1 34
  • 89 (a)
(Mus musculus)
Mammalia Cdk11b 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 86 (a)
(Canis familiaris)
Mammalia -- 34
  • 83 (a)
(Gallus gallus)
Aves CDC2L1 34
  • 84 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16205 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23888 33
(Danio rerio)
Actinopterygii cdk11b 34
  • 87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pitslre 34
  • 39 (a)
(Caenorhabditis elegans)
Secernentea B0495.2 34
  • 40 (a)
ZC504.3 34
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 34
  • 27 (a)
(Glycine max)
eudicotyledons Gma.11311 33
(Hordeum vulgare)
Liliopsida Hv.6051 33
(Oryza sativa)
Liliopsida Os.11889 33
(Triticum aestivum)
Liliopsida Ta.4787 33
Species where no ortholog for CDK11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDK11B Gene

Gene Tree for CDK11B (if available)
Gene Tree for CDK11B (if available)

Paralogs for CDK11B Gene

Variants for CDK11B Gene

Sequence variations from dbSNP and Humsavar for CDK11B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000008651 -- 1,642,062(+) TACCA(C/T)CACCC intron-variant
rs1000037479 -- 1,654,835(+) CTGTA(-/T)TTTTA intron-variant
rs1000078484 -- 1,641,171(+) ACAGG(C/T)AGGAT intron-variant
rs1000423450 -- 1,636,319(+) CCGGC(A/T)GCACT intron-variant
rs1000704026 -- 1,659,339(+) GAGCA(A/G)AATGC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CDK11B Gene

Variant ID Type Subtype PubMed ID
nsv950452 CNV deletion 24416366
nsv947410 CNV duplication 23825009
nsv545018 CNV loss 21841781
nsv545017 CNV loss 21841781
nsv482937 CNV loss 15286789
nsv1160797 CNV duplication 26073780
nsv1139466 CNV duplication 24896259
nsv1118425 CNV duplication 24896259
nsv1075361 CNV duplication 25765185
nsv1073627 CNV deletion 25765185
nsv10161 CNV gain+loss 18304495
esv3585007 CNV loss 21293372
esv3575582 CNV gain 25503493
esv3550788 CNV deletion 23714750
esv3390461 CNV duplication 20981092
esv27786 CNV gain 19812545
esv2760410 CNV gain+loss 21179565
esv2758913 CNV gain+loss 17122850
esv2661270 CNV deletion 23128226
esv1336011 CNV insertion 17803354
dgv8n100 CNV loss 25217958
dgv5n111 CNV deletion 26073780
dgv3n67 CNV gain 20364138
dgv2e199 CNV deletion 23128226

Variation tolerance for CDK11B Gene

Gene Damage Index Score: 2.65; 45.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK11B Gene

Disorders for CDK11B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK11B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDK11B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDK11B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK11B Gene

Publications for CDK11B Gene

  1. The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. (PMID: 14511641) Mikolajczyk M … Nelson M (Biochemical and biophysical research communications 2003) 2 3 4 60
  2. CDK11 complexes promote pre-mRNA splicing. (PMID: 12501247) Hu D … Kidd VJ (The Journal of biological chemistry 2003) 3 4 22 60
  3. Structure and expression of the human p58clk-1 protein kinase chromosomal gene. (PMID: 1639388) Eipers PG … Kidd VJ (Genomics 1992) 3 4 22 60
  4. SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation. (PMID: 25965346) Yang L … Chroneos ZC (PloS one 2015) 3 4 60
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 45 60

Products for CDK11B Gene

Sources for CDK11B Gene

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