CDK11B Gene
protein-coding GIFtS: 52
GCID: GC01M001574
|
|
cyclin-dependent kinase 11B(Previous name: cell division cycle 2-like 1 (PITSLRE proteins) )
(Previous symbol: CDC2L1)
| |
Aliases
for CDK11B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cyclin-Dependent Kinase 11B1 2 | | PITSLREA2 3 | | CDC2L11 2 3 5 | | PK582 3 | | CDK112 3 5 | | P58 CLK-12 3 | | CDK11-P1101 | | PITSLRE Serine/Threonine-Protein Kinase CDC2L12 3 | | CDK11-P461 | | EC 2.7.11.223 8 | | CDK11-P581 | | CDC-Related Protein Kinase P582 | | Cell Division Cycle 2-Like 1 (PITSLRE Proteins)1 2 | | P585 | | Cell Division Cycle 2-Like Protein Kinase 12 3 | | P58CDC2L11 | | Cell Division Protein Kinase 11B2 3 | | P58CLK-11 | | Galactosyltransferase-Associated Protein Kinase P58/GTA2 3 | | P585 | | CLK-12 3 | | EC 2.7.118 |
Export aliases for CDK11B gene to outside databasesPrevious GC identifers: GC01M001628 GC01M001572 |
Summaries
for CDK11B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CDK11B:
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to beessential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in thesame chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist oftwo identical, tandemly linked genomic regions which are thought to be a part of the larger region that has beenduplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCNgenes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cellapoptosis. Several alternatively spliced variants of this gene have been reported. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms havebeen suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58isoform may act as a negative regulator of normal cell cycle progression
Gene Wiki entry for CDK11B (CDC2L1)
|
Genomic Views
for CDK11B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CDK11B
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDK11B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK11B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33CDK11B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M001574: view genomic region
(about GC identifiers)
Start:
|
1,570,603 bp from pter |
End:
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1,590,473 bp from pter |
Size:
|
19,871 bases |
Orientation:
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minus strand |
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Proteins
for CDK11B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127 (See
protein sequence)Recommended Name: Cyclin-dependent kinase 11B Size: 795 amino acids; 92707 Da
Cofactor: Magnesium
Subunit: The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts withRNPS1. The p58 isoform but not the p110 isoforms or p110C interacts with CCND3. The p110 isoforms are found in largemolecular weight complexes containing CCNL1 and SFRS7
Subcellular location: Cytoplasm. Nucleus
Miscellaneous: Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain attheir C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediatedalternative initiation of translation
Caution: Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B orone/some of the isoforms of each
Sequence caution: Sequence=AAC83664.1; Type=Erroneous gene model prediction; Sequence=AAF36538.1; Type=Erroneousinitiation;
Secondary accessions: O95265 Q12817 Q12818 Q12819 Q12820 Q12822 Q8N530 Q9NZS5 Q9UBJ0 Q9UBQ1 Q9UBR0Q9UNY2 Q9UP57 Q9UP58 Q9UP59Alternative splicing, Alternative initiation: 10 isoforms: P21127-1 P21127-2 P21127-3 P21127-4 P21127-5 P21127-6 P21127-8 P21127-9 P21127-10 P21127-12 (Produced by alternative initiation at Met-357 of isoform SV9)Explore the universe of human proteins at neXtProt for CDK11B: NX_P21127
Post-translational modifications:
During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases toproduce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins1
Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P21127
4/13 DME Specific Peptides for CDK11B (P21127) (see all 13)
CDK11B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_277021.1 NP_277022.1 NP_277023.1 NP_277024.1 NP_277027.1 NP_277028.1
ENSEMBL proteins: ENSP00000463404 ENSP00000344418 ENSP00000464036 ENSP00000463200 ENSP00000464016 ENSP00000463048 Reactome Protein details: P21127
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CDK11B for ontologies About GeneDecksing
CDK11B Antibody Products:
Assay Products for CDK11B: |
Protein
Domains /
Families
for CDK11B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDK11B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P21127ProtoNet protein and cluster: P21127 UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamilySimilarity: Contains 1 protein kinase domain |
Function
for CDK11B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms havebeen suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58isoform may act as a negative regulator of normal cell cycle progressionCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595activates it (By similarity)Induction: The p58 isoform is specifically induced in G2/M phase of the cell cycleEnzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK11B (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK11B (see all 9)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): CDK11B (NM_033489) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDK11B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK11B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK11B |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
CDK11B for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for CDK11B:
Animal Models:
Mouse knock-out Cdk11btm1Vjk for CDK11B
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Cdk11b):
CDK11B for phenotypes About GeneDecksing
|
Pathways & Interactions
for CDK11B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Recruitment of mitotic centrosome proteins and complexes | | | 2 | Cell Cycle | | | 3 | Cell Cycle / Checkpoint Control | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for CDK11B
5/6 
Reactome Pathways for CDK11B (see all 6)
CDK11B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK11B
5/24 Interacting proteins for CDK11B (P211271, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 24)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
CDK11B for ontologies About GeneDecksing
|
Drugs & Compounds
for CDK11B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CDK11B for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for CDK11B |
 Browse Tocris compounds for CDK11B
3 HMDB Compounds for CDK11B About this table
Search CenterWatch for drugs/clinical trials and news about CDK11B / CD11B
|
Transcripts
for CDK11B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDK11B gene (8 alternative transcripts): NM_033486.1 NM_033487.1 NM_033488.1 NM_033489.1 NM_033492.1 NM_033493.1 NM_001787.1 NM_033490.1 Unigene Cluster for CDK11B: Cyclin-dependent kinase 11B Hs.709182 [show with all ESTs]Unigene Representative Sequence: AK0000816 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000513088 ENST00000341028(uc001ahc.1) ENST00000407249 ENST00000317673
ENST00000340677 ENST00000341832(uc009vkj.2 uc010nyr.1 uc001ags.1 uc001agt.1 uc001aha.1 uc001agw.1 uc001agv.1 uc001agy.1 uc001agx.1 uc001agz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK11B (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK11B (see all 9)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): CDK11B (NM_033489) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDK11B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK11B |
Additional cDNA sequence: AF067512.1 AF067513.1 AF067514.1 AF067515.1 AF067516.1 AF174497.1 AK000081.1 AK295607.1 AK301495.1 AK303446.1 AK303451.1 AK304679.1 BC009375.2 BC062579.1 BC139777.1 BC140714.1 BC171773.1 U04816.1 U04817.1 U04818.1 U04824.1 24/32 DOTS entries (see all 32): DT.40308783 DT.92453672 DT.95224500 DT.75133401 DT.92453679 DT.92453688 DT.100887081 DT.91946997 DT.100887093 DT.100887090 DT.121399105 DT.121399199 DT.100887079 DT.100887091 DT.99977005 DT.121399213 DT.121643403 DT.92453670 DT.100044908 DT.40105999 DT.40223002 DT.101985235 DT.92453681 DT.95224492 24/499 AceView cDNA sequences (see all 499): BF589317 BI753229 AA159745 AL519809 BQ717326 CK823856 BE047587 NM_182838 BE328002 AL043340 CK429285 AI263381 AW662168 AA300538 BM761686 BX646365 AI066775 CR606630 BF058069 BQ045355 BF868528 AW292671 BC014464 CB161273
GeneLoc Exon Structure
|
Expression
for CDK11B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDK11B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CDK11B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDK11B
SOURCE GeneReport for Unigene cluster: Hs.709182
UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution
SABiosciences Custom PCR Arrays for CDK11B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK11B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK11B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK11B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK11B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK11B |
Orthologs
for CDK11B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CDK11B gene from 8/34 species (see all 34) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CDC2L11 |
cell division cycle 2-like 1 (PITSLRE proteins) |
77.94(n)
93.37(a) |
|
419406 NM_001030871.2 NP_001026042.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CDK11A6 |
-- |
93(a) |
1 → many |
GL344966.1(2083-13920) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.238882 |
Xenopus laevis transcribed sequence with strong similarity more |
76.01(n) |
|
BU916896.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CA472942.12 |
-- |
83.33(n) |
|
CA472942.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pitslre1 |
CG4268-PA |
53.27(n)
49.51(a) |
|
40292 NM_168869.2 NP_730563.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
B0495.21 |
Protein B0495.2 |
47.65(n)
42.25(a) |
|
174244 NM_063216.4 NP_495617.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G675801 |
protein kinase-like protein |
55.51(n)
57.05(a) |
|
843079 NM_105425.4 NP_176925.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.118892 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
69.42(n) |
|
AK111593.1 |
ENSEMBL Gene Tree for CDK11B (if available)
TreeFam Gene Tree for CDK11B (if available) |
Paralogs
for CDK11B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDK11B gene
- CDK11A1 2 CDK102
18/60 SIMAP similar genes for CDK11B using alignment to 6 protein entries: CD11B_HUMAN (see all proteins)
(see all similar genes):CDC2L2 CDC2L1 CDK11A DYRK4 NDUFA9 CDK10
CDC2 PHKG2 CDK1 CDK3 CDK5 CDK6
DKFZp686L20222 NEK9 CDK2 CDK7 CDK9 CDK4
CDK11B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CDK11B
PGOHUM00000247147
|
Genomic Variants
for CDK11B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDK11B (1570603 - 1590473 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for CDK11B
13 CNVs: 2042 22925 38832 2295 30362 3276 0002 60788 31596 84001 63709 23342 74286
3 Indels: 11373 23983 59918 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CDK11B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDK11B for disorders About GeneDecksing
OMIM gene information: 176873
OMIM disorders: --
11  diseases for CDK11B: About MalaCardsendodermal sinus tumor childhood endodermal sinus tumor neuroblastoma non-hodgkin lymphoma
hodgkin's lymphoma sinusitis hepatocellular carcinoma alzheimer's disease
melanoma breast cancer carcinoma
2 Novoseek disease relationships for CDK11B gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| melanoma |
19.5 |
2 |
15344906 (1) |
| tumors |
0 |
1 |
9162192 (1) |
Human Genome Epidemiology (HuGE) Navigator: CDK11B (1 document)
Export disorders for CDK11B gene to outside databases
|
Publications
for CDK11B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDK11B gene, integrated from 9 sources (see all 74):
(articles sorted by number of sources associating them with CDK11B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. (PubMed id 14511641)1, 2, 3 Mikolajczyk M.... Nelson M. (2003)
- CDK11 complexes promote pre-mRNA splicing. (PubMed id 12501247)1, 2, 9 Hu D.... Kidd V.J. (2003)
- Structure and expression of the human p58clk-1 protein kinase chromosomal gene. (PubMed id 1639388)1, 2, 9 Eipers P.G.... Kidd V.J. (1992)
- Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The cyclin-dependent kinase 11 interacts with 14-3-3 proteins. (PubMed id 15883043)1, 2 Feng Y....Nelson M.A. (2005)
- The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. (PubMed id 12624090)1, 2 Chen S.... Gu J. (2003)
- Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. (PubMed id 10882096)1, 2 Cornelis S....Beyaert R. (2000)
- Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PubMed id 9750192)1, 2 Gururajan R....Kidd V.J. (1998)
|
External Searches for CDK11B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDK11B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDK11B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDK11B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDK11B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CDK11B gene:
Search GeneIP for patents involving CDK11B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CDK11B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CDK11B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK11B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK11B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDK11B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK11B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK11B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CDK11B | | OriGene Custom Protein Services for CDK11B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK11B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK11B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK11B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK11B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK11B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK11B |
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| | Antibodies & Assays for CDK11B |
| | | | Search Tocris compounds for CDK11B |
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 | | | CDK11B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK11B |
|  |  |  | | | | ThermoFisher Antibodies for CDK11B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK11B |
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