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Aliases for CDK11B Gene

Aliases for CDK11B Gene

  • Cyclin-Dependent Kinase 11B 2 3 5
  • Galactosyltransferase-Associated Protein Kinase P58/GTA 3 4
  • Cell Division Cycle 2-Like 1 (PITSLRE Proteins) 2 3
  • PITSLRE Serine/Threonine-Protein Kinase CDC2L1 3 4
  • Cell Division Protein Kinase 11B 3 4
  • EC 4 63
  • P58 CLK-1 3 4
  • PITSLREA 3 4
  • CDC2L1 3 4
  • CDK11 3 4
  • CLK-1 3 4
  • PK58 3 4
  • Cell Division Cycle 2-Like Protein Kinase 1 4
  • CDC-Related Protein Kinase P58 3
  • CDK11-P110 3
  • CDK11-P46 3
  • CDK11-P58 3
  • P58CDC2L1 3
  • EC 2.7.11 63
  • P58CLK-1 3
  • P58 3

External Ids for CDK11B Gene

Previous HGNC Symbols for CDK11B Gene

  • CDC2L1

Previous GeneCards Identifiers for CDK11B Gene

  • GC01M001628
  • GC01M001572
  • GC01M001574

Summaries for CDK11B Gene

Entrez Gene Summary for CDK11B Gene

  • This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CDK11B Gene

CDK11B (Cyclin-Dependent Kinase 11B) is a Protein Coding gene. Diseases associated with CDK11B include Neuroblastoma. Among its related pathways are Cell Cycle, Mitotic and DNA Damage. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is CDK4.

UniProtKB/Swiss-Prot for CDK11B Gene

  • Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.

Gene Wiki entry for CDK11B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK11B Gene

Genomics for CDK11B Gene

Regulatory Elements for CDK11B Gene

Enhancers for CDK11B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDK11B on UCSC Golden Path with GeneCards custom track

Promoters for CDK11B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDK11B on UCSC Golden Path with GeneCards custom track

Genomic Location for CDK11B Gene

1,635,226 bp from pter
1,659,839 bp from pter
24,614 bases
Minus strand

Genomic View for CDK11B Gene

Genes around CDK11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK11B Gene

Proteins for CDK11B Gene

  • Protein details for CDK11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cyclin-dependent kinase 11B
    Protein Accession:
    Secondary Accessions:
    • O95265
    • Q12817
    • Q12818
    • Q12819
    • Q12820
    • Q12822
    • Q8N530
    • Q9NZS5
    • Q9UBJ0
    • Q9UBQ1
    • Q9UBR0
    • Q9UNY2
    • Q9UP57
    • Q9UP58
    • Q9UP59

    Protein attributes for CDK11B Gene

    795 amino acids
    Molecular mass:
    92707 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. The p58 isoform but not the p110 isoforms or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7.
    • Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.
    • Sequence=AAC83664.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAF36538.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK11B Gene

neXtProt entry for CDK11B Gene

Proteomics data for CDK11B Gene at MOPED

Post-translational modifications for CDK11B Gene

  • During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins.
  • Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.
  • Ubiquitination at Lys 660
  • Modification sites at PhosphoSitePlus

Domains & Families for CDK11B Gene

Gene Families for CDK11B Gene

Protein Domains for CDK11B Gene

Suggested Antigen Peptide Sequences for CDK11B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK11B: view

Function for CDK11B Gene

Molecular function for CDK11B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595 activates it.
UniProtKB/Swiss-Prot Function:
Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
UniProtKB/Swiss-Prot Induction:
The p58 isoform is specifically induced in G2/M phase of the cell cycle.

Enzyme Numbers (IUBMB) for CDK11B Gene

genes like me logo Genes that share phenotypes with CDK11B: view

Human Phenotype Ontology for CDK11B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDK11B Gene

Localization for CDK11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK11B Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for CDK11B Gene COMPARTMENTS Subcellular localization image for CDK11B gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for CDK11B Gene

Pathways & Interactions for CDK11B Gene

genes like me logo Genes that share pathways with CDK11B: view

Pathways by source for CDK11B Gene

1 GeneTex pathway for CDK11B Gene
1 Cell Signaling Technology pathway for CDK11B Gene

SIGNOR curated interactions for CDK11B Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 12501247
GO:0006915 apoptotic process NAS 9750192
GO:0008283 cell proliferation TAS 8195233
genes like me logo Genes that share ontologies with CDK11B: view

Drugs & Compounds for CDK11B Gene

(2) Drugs for CDK11B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for CDK11B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK11B: view

Transcripts for CDK11B Gene

Unigene Clusters for CDK11B Gene

Cyclin-dependent kinase 11B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK11B Gene

No ASD Table

Relevant External Links for CDK11B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDK11B Gene

mRNA expression in normal human tissues for CDK11B Gene

Protein differential expression in normal tissues from HIPED for CDK11B Gene

This gene is overexpressed in Pancreas (20.4), Lung (15.0), Testis (8.5), and Ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK11B Gene

SOURCE GeneReport for Unigene cluster for CDK11B Gene Hs.709182

mRNA Expression by UniProt/SwissProt for CDK11B Gene

Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
genes like me logo Genes that share expression patterns with CDK11B: view

Protein tissue co-expression partners for CDK11B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK11B Gene

Orthologs for CDK11B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK11B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDC2L1 36
  • 89 (a)
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
(Mus musculus)
Mammalia Cdk11b 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
(Gallus gallus)
Aves CDC2L1 36
  • 84 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16205 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23888 35
(Danio rerio)
Actinopterygii cdk11b 36
  • 87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pitslre 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea B0495.2 36
  • 40 (a)
ZC504.3 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 36
  • 27 (a)
(Glycine max)
eudicotyledons Gma.11311 35
(Hordeum vulgare)
Liliopsida Hv.6051 35
(Oryza sativa)
Liliopsida Os.11889 35
(Triticum aestivum)
Liliopsida Ta.4787 35
Species with no ortholog for CDK11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDK11B Gene

Gene Tree for CDK11B (if available)
Gene Tree for CDK11B (if available)

Paralogs for CDK11B Gene

Paralogs for CDK11B Gene Pseudogenes for CDK11B Gene

genes like me logo Genes that share paralogs with CDK11B: view

Variants for CDK11B Gene

Sequence variations from dbSNP and Humsavar for CDK11B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_041958 -
VAR_041959 -
VAR_041960 -
VAR_041961 -
VAR_041962 -

Structural Variations from Database of Genomic Variants (DGV) for CDK11B Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
dgv9e1 CNV Complex 17122850
dgv43n71 CNV Loss 21882294
dgv44n71 CNV Gain+Loss 21882294
nsv871954 CNV Loss 21882294
nsv871540 CNV Gain 21882294
dgv45n71 CNV Loss 21882294
nsv870847 CNV Loss 21882294
nsv871940 CNV Loss 21882294
dgv46n71 CNV Loss 21882294
esv2661270 CNV Deletion 23128226
dgv47n71 CNV Loss 21882294
nsv871583 CNV Loss 21882294
esv27786 CNV Gain 19812545
esv2748696 CNV Deletion 23290073
dgv48n71 CNV Gain 21882294
nsv871676 CNV Loss 21882294
nsv871749 CNV Gain+Loss 21882294
nsv870598 CNV Gain 21882294
dgv2e199 CNV Deletion 23128226
esv1336011 CNV Insertion 17803354
dgv3n67 CNV Gain 20364138
dgv49n71 CNV Loss 21882294
dgv50n71 CNV Gain 21882294
nsv871030 CNV Gain 21882294
esv2677252 CNV Deletion 23128226
esv1758309 CNV Deletion 17803354
esv6099 CNV Gain 19470904
dgv51n71 CNV Loss 21882294
dgv10e1 CNV Complex 17122850
nsv482957 CNV Loss 15286789
dgv52n71 CNV Loss 21882294
dgv53n71 CNV Gain 21882294
nsv871560 CNV Loss 21882294
nsv442858 CNV CNV 18776908
nsv436343 CNV Deletion 17901297
nsv834091 CNV Loss 17160897
nsv482168 CNV Gain 20164927
nsv822475 CNV Gain 20364138
nsv822586 CNV Gain 20364138
nsv822697 CNV Loss 20364138
nsv871903 CNV Gain+Loss 21882294
nsv871121 CNV Gain 21882294
essv725 CNV CNV 17122850
nsv822809 CNV Loss 20364138
nsv509368 CNV Insertion 20534489
esv2748807 CNV Deletion 23290073
nsv436733 CNV Insertion 17901297
esv2748918 CNV Deletion 23290073
nsv159838 CNV Loss 16902084
esv988165 CNV Deletion 20482838
esv1455500 CNV Deletion 17803354
nsv160496 CNV Loss 16902084
dgv3e201 CNV Deletion 23290073
dgv4e201 CNV Deletion 23290073
esv2749585 CNV Deletion 23290073
nsv160062 CNV Loss 16902084
esv2749696 CNV Deletion 23290073
esv6106 CNV Loss 19470904
nsv160158 CNV Insertion 16902084
esv2668621 CNV Deletion 23128226

Variation tolerance for CDK11B Gene

Gene Damage Index Score: 2.65; 45.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDK11B Gene

Disorders for CDK11B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK11B Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDK11B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDK11B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK11B Gene

Publications for CDK11B Gene

  1. The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. (PMID: 14511641) Mikolajczyk M. … Nelson M. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 67
  2. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3
  3. Regulation of stability of cyclin-dependent kinase CDK11p110 and a caspase-processed form, CDK11p46, by Hsp90. (PMID: 15344906) Mikolajczyk M. … Nelson M.A. (Biochem. J. 2004) 3 23
  4. CDK11 complexes promote pre-mRNA splicing. (PMID: 12501247) Hu D. … Kidd V.J. (J. Biol. Chem. 2003) 3 23
  5. A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3. (PMID: 7777541) White P.S. … Brodeur G.M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 23

Products for CDK11B Gene

Sources for CDK11B Gene