Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDK11B Gene

Aliases for CDK11B Gene

  • Cyclin-Dependent Kinase 11B 2 3
  • CDC2L1 3 4 6
  • CDK11 3 4 6
  • Galactosyltransferase-Associated Protein Kinase P58/GTA 3 4
  • Cell Division Cycle 2-Like 1 (PITSLRE Proteins) 2 3
  • PITSLRE Serine/Threonine-Protein Kinase CDC2L1 3 4
  • Cell Division Protein Kinase 11B 3 4
  • EC 2.7.11.22 4 63
  • P58 CLK-1 3 4
  • PITSLREA 3 4
  • CLK-1 3 4
  • PK58 3 4
  • P58 3 6
  • Cell Division Cycle 2-Like Protein Kinase 1 4
  • CDC-Related Protein Kinase P58 3
  • CDK11-P110 3
  • CDK11-P46 3
  • CDK11-P58 3
  • P58CDC2L1 3
  • EC 2.7.11 63
  • P58CLK-1 3

External Ids for CDK11B Gene

Previous HGNC Symbols for CDK11B Gene

  • CDC2L1

Previous GeneCards Identifiers for CDK11B Gene

  • GC01M001628
  • GC01M001572
  • GC01M001574

Summaries for CDK11B Gene

Entrez Gene Summary for CDK11B Gene

  • This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for CDK11B Gene

CDK11B (Cyclin-Dependent Kinase 11B) is a Protein Coding gene. Diseases associated with CDK11B include childhood endodermal sinus tumor and endodermal sinus tumor. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK12.

UniProtKB/Swiss-Prot for CDK11B Gene

  • Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.

Gene Wiki entry for CDK11B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK11B Gene

Genomics for CDK11B Gene

Genomic Location for CDK11B Gene

Start:
1,635,226 bp from pter
End:
1,722,818 bp from pter
Size:
87,593 bases
Orientation:
Minus strand

Genomic View for CDK11B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK11B Gene

No data available for Regulatory Elements for CDK11B Gene

Proteins for CDK11B Gene

  • Protein details for CDK11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21127-CD11B_HUMAN
    Recommended name:
    Cyclin-dependent kinase 11B
    Protein Accession:
    P21127
    Secondary Accessions:
    • O95265
    • Q12817
    • Q12818
    • Q12819
    • Q12820
    • Q12822
    • Q8N530
    • Q9NZS5
    • Q9UBJ0
    • Q9UBQ1
    • Q9UBR0
    • Q9UNY2
    • Q9UP57
    • Q9UP58
    • Q9UP59

    Protein attributes for CDK11B Gene

    Size:
    795 amino acids
    Molecular mass:
    92707 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. The p58 isoform but not the p110 isoforms or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7.
    Miscellaneous:
    • Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation
    SequenceCaution:
    • Sequence=AAC83664.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAF36538.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK11B Gene

neXtProt entry for CDK11B Gene

Proteomics data for CDK11B Gene at MOPED

Post-translational modifications for CDK11B Gene

  • During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins
  • Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.
  • Ubiquitination at Lys660, Lys673, and Lys719
  • Modification sites at PhosphoSitePlus

Other Protein References for CDK11B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDK11B (CDK11B)

Domains for CDK11B Gene

Gene Families for CDK11B Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

Protein Domains for CDK11B Gene

Suggested Antigen Peptide Sequences for CDK11B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21127

UniProtKB/Swiss-Prot:

CD11B_HUMAN :
  • P21127
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK11B: view

Function for CDK11B Gene

Molecular function for CDK11B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595 activates it.
UniProtKB/Swiss-Prot Function:
Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
UniProtKB/Swiss-Prot Induction:
The p58 isoform is specifically induced in G2/M phase of the cell cycle.

Enzyme Numbers (IUBMB) for CDK11B Gene

Gene Ontology (GO) - Molecular Function for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 1639388
GO:0004674 protein serine/threonine kinase activity IDA 12501247
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 12624090
genes like me logo Genes that share ontologies with CDK11B: view
genes like me logo Genes that share phenotypes with CDK11B: view

Animal Models for CDK11B Gene

MGI Knock Outs for CDK11B:

Animal Model Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CDK11B Gene

Localization for CDK11B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK11B Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8195233
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDK11B: view

No data available for Subcellular locations from COMPARTMENTS for CDK11B Gene

Pathways for CDK11B Gene

genes like me logo Genes that share pathways with CDK11B: view

Pathways by source for CDK11B Gene

Gene Ontology (GO) - Biological Process for CDK11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEP 10882096
GO:0006355 regulation of transcription, DNA-templated NAS 9750192
GO:0006468 protein phosphorylation IDA 12501247
GO:0006915 apoptotic process NAS 9750192
GO:0007067 mitotic nuclear division NAS 1639388
genes like me logo Genes that share ontologies with CDK11B: view

Compounds for CDK11B Gene

(3) HMDB Compounds for CDK11B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with CDK11B: view

Transcripts for CDK11B Gene

Unigene Clusters for CDK11B Gene

Cyclin-dependent kinase 11B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK11B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK11B Gene

No ASD Table

Relevant External Links for CDK11B Gene

GeneLoc Exon Structure for
CDK11B
ECgene alternative splicing isoforms for
CDK11B

Expression for CDK11B Gene

mRNA expression in normal human tissues for CDK11B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CDK11B Gene

This gene is overexpressed in Pancreas (20.4), Lung (15.0), Testis (8.5), and Ovary (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK11B Gene

SOURCE GeneReport for Unigene cluster for CDK11B Gene Hs.709182

mRNA Expression by UniProt/SwissProt for CDK11B Gene

P21127-CD11B_HUMAN
Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
genes like me logo Genes that share expressions with CDK11B: view

Expression partners for CDK11B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDK11B Gene

Orthologs for CDK11B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDK11B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cdk11b 16
Cdk11b 36
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CDC2L1 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
chicken
(Gallus gallus)
Aves CDC2L1 36
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16205 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23888 35
zebrafish
(Danio rerio)
Actinopterygii cdk11b 36
  • 87 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pitslre 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.2 36
  • 40 (a)
ManyToMany
ZC504.3 36
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 36
  • 27 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.11311 35
barley
(Hordeum vulgare)
Liliopsida Hv.6051 35
rice
(Oryza sativa)
Liliopsida Os.11889 35
wheat
(Triticum aestivum)
Liliopsida Ta.4787 35
Species with no ortholog for CDK11B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CDK11B Gene

ENSEMBL:
Gene Tree for CDK11B (if available)
TreeFam:
Gene Tree for CDK11B (if available)

Paralogs for CDK11B Gene

Paralogs for CDK11B Gene

Pseudogenes.org Pseudogenes for CDK11B Gene

genes like me logo Genes that share paralogs with CDK11B: view

Variants for CDK11B Gene

Sequence variations from dbSNP and Humsavar for CDK11B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1059814 -- 1,636,712(+) ATTTC(C/T)GAATT reference, synonymous-codon
rs1059815 -- 1,636,715(+) TCCGA(A/C)TTCCC reference, missense
rs3765907 -- 1,641,261(+) CCCAG(C/T)GCTTT intron-variant
rs3765908 -- 1,641,275(+) AGGCC(A/G)AGGCG intron-variant
rs3765910 -- 1,641,373(+) gcgtg(C/G)tggcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK11B Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
dgv9e1 CNV Complex 17122850
dgv43n71 CNV Loss 21882294
dgv44n71 CNV Gain+Loss 21882294
nsv871954 CNV Loss 21882294
nsv871540 CNV Gain 21882294
dgv45n71 CNV Loss 21882294
nsv870847 CNV Loss 21882294
nsv871940 CNV Loss 21882294
dgv46n71 CNV Loss 21882294
esv2661270 CNV Deletion 23128226
dgv47n71 CNV Loss 21882294
nsv871583 CNV Loss 21882294
esv27786 CNV Gain 19812545
esv2748696 CNV Deletion 23290073
dgv48n71 CNV Gain 21882294
nsv871676 CNV Loss 21882294
nsv871749 CNV Gain+Loss 21882294
nsv870598 CNV Gain 21882294
dgv2e199 CNV Deletion 23128226
esv1336011 CNV Insertion 17803354
dgv3n67 CNV Gain 20364138
dgv49n71 CNV Loss 21882294
dgv50n71 CNV Gain 21882294
nsv871030 CNV Gain 21882294
esv2677252 CNV Deletion 23128226
esv1758309 CNV Deletion 17803354
esv6099 CNV Gain 19470904
dgv51n71 CNV Loss 21882294
dgv10e1 CNV Complex 17122850
nsv482957 CNV Loss 15286789
dgv52n71 CNV Loss 21882294
dgv53n71 CNV Gain 21882294
nsv871560 CNV Loss 21882294
nsv442858 CNV CNV 18776908
nsv436343 CNV Deletion 17901297
nsv834091 CNV Loss 17160897
nsv482168 CNV Gain 20164927
nsv822475 CNV Gain 20364138
nsv822586 CNV Gain 20364138
nsv822697 CNV Loss 20364138
nsv871903 CNV Gain+Loss 21882294
nsv871121 CNV Gain 21882294
essv725 CNV CNV 17122850
nsv822809 CNV Loss 20364138
nsv509368 CNV Insertion 20534489
esv2748807 CNV Deletion 23290073
nsv436733 CNV Insertion 17901297
esv2748918 CNV Deletion 23290073
nsv159838 CNV Loss 16902084
esv988165 CNV Deletion 20482838
esv1455500 CNV Deletion 17803354
nsv160496 CNV Loss 16902084
dgv3e201 CNV Deletion 23290073
dgv4e201 CNV Deletion 23290073
esv2749585 CNV Deletion 23290073
nsv160062 CNV Loss 16902084
esv2749696 CNV Deletion 23290073
esv6106 CNV Loss 19470904
nsv160158 CNV Insertion 16902084
esv2668621 CNV Deletion 23128226

Relevant External Links for CDK11B Gene

HapMap Linkage Disequilibrium report
CDK11B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK11B Gene

Disorders for CDK11B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CDK11B Gene in MalaCards »

(3) Diseases for CDK11B Gene including...

(2) Novoseek inferred disease relationships for CDK11B Gene

Disease -log(P) Hits PubMed IDs
melanoma 19.5 1
tumors 0 1

Relevant External Links for CDK11B

Genetic Association Database (GAD)
CDK11B
Human Genome Epidemiology (HuGE) Navigator
CDK11B
genes like me logo Genes that share disorders with CDK11B: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CDK11B Gene

Publications for CDK11B Gene

  1. Structure and expression of the human p58clk-1 protein kinase chromosomal gene. (PMID: 1639388) Eipers P.G. … Kidd V.J. (Genomics 1992) 3 4 23
  2. CDK11 complexes promote pre-mRNA splicing. (PMID: 12501247) Hu D. … Kidd V.J. (J. Biol. Chem. 2003) 3 4 23
  3. The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. (PMID: 14511641) Mikolajczyk M. … Nelson M. (Biochem. Biophys. Res. Commun. 2003) 2 3 4
  4. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PMID: 9750192) Gururajan R. … Kidd V.J. (Genome Res. 1998) 3 4
  5. Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. (PMID: 10882096) Cornelis S. … Beyaert R. (Mol. Cell 2000) 3 4

Products for CDK11B Gene

Sources for CDK11B Gene

Back to Top

Content