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CDK11B Gene

protein-coding   GIFtS: 52
GCID: GC01M001574

Cyclin-Dependent Kinase 11B

(Previous name: cell division cycle 2-like 1 (PITSLRE proteins))
(Previous symbol: CDC2L1)
  See CDK11B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 11B1 2     EC 2.7.11.223 8
CDC2L11 2 3 5     CDK11-p1102
CDK112 3 5     CDK11-p462
Cell Division Cycle 2-Like 1 (PITSLRE Proteins)1 2     CDK11-p582
Cell Division Protein Kinase 11B2 3     CDC-Related Protein Kinase P582
Galactosyltransferase-Associated Protein Kinase P58/GTA2 3     p582
CLK-12 3     p58CDC2L12
PITSLREA2 3     p58CLK-12
PK582 3     Cell Division Cycle 2-Like Protein Kinase 13
P58 CLK-12 3     P585
PITSLRE Serine/Threonine-Protein Kinase CDC2L12 3     EC 2.7.118

External Ids:    HGNC: 17291   Entrez Gene: 9842   Ensembl: ENSG000002483337   OMIM: 1768735   UniProtKB: P211273   

Export aliases for CDK11B gene to outside databases

Previous GC identifers: GC01M001628 GC01M001572


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK11B Gene:
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be
essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene
in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22,
consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region
that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma
with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was
demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been
reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDK11B Gene:
CDK11B (cyclin-dependent kinase 11B) is a protein-coding gene. Diseases associated with CDK11B include childhood endodermal sinus tumor, and endodermal sinus tumor. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK11A.

UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127
Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms
have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein
SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression

Gene Wiki entry for CDK11B (CDC2L1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CDK11B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CDK11B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK11B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

CDK11B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK11B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001574:  view genomic region     (about GC identifiers)

Start:
1,570,603 bp from pter      End:
1,590,473 bp from pter
Size:
19,871 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 11B  
Size: 795 amino acids; 92707 Da
Cofactor: Magnesium
Subunit: The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts
with RNPS1. The p58 isoform but not the p110 isoforms or p110C interacts with CCND3. The p110 isoforms are found
in large molecular weight complexes containing CCNL1 and SFRS7
Miscellaneous: Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain
at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated
alternative initiation of translation
Caution: Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B
or one/some of the isoforms of each
Sequence caution: Sequence=AAC83664.1; Type=Erroneous gene model prediction; Sequence=AAF36538.1; Type=Erroneous
initiation;
Secondary accessions: O95265 Q12817 Q12818 Q12819 Q12820 Q12822 Q8N530 Q9NZS5 Q9UBJ0 Q9UBQ1
Q9UBR0 Q9UNY2 Q9UP57 Q9UP58 Q9UP59
Alternative splicing, Alternative initiation: 10 isoforms:  P21127-1   P21127-2   P21127-3   P21127-4   P21127-5   P21127-6   P21127-8   P21127-9   
P21127-10   P21127-12   (Produced by alternative initiation at Met-357 of isoform SV9)

Explore the universe of human proteins at neXtProt for CDK11B: NX_P21127

Explore proteomics data for CDK11B at MOPED

Post-translational modifications: 

  • During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to
    produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins1
  • Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated1
  • Ubiquitination2 at Lys660, Lys673, Lys719
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK11B (P21127) (see all 13)
     VKRGTSP  ILHRDLK  EQLERKR  VVTLWYR 


    See CDK11B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_277021.1  NP_277022.1  NP_277023.1  NP_277024.1  NP_277027.1  NP_277028.1  

    ENSEMBL proteins: 
     ENSP00000463404   ENSP00000344418   ENSP00000464036   ENSP00000463200   ENSP00000464016  
     ENSP00000463048  
    Reactome Protein details: P21127

    CDK11B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 11B
    PITSLRE subfamily

    4 InterPro protein domains:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P21127

    ProtoNet protein and cluster: P21127

    UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDK11B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD11B_HUMAN, P21127
    Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms
    have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein
    SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595
    activates it (By similarity)
    Induction: The p58 isoform is specifically induced in G2/M phase of the cell cycle

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS1639388
    GO:0004674protein serine/threonine kinase activity IDA12501247
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12624090
         
    Find genes that share ontologies with CDK11B           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for CDK11B:
     Decreased substrate adherent c  Decreased viability  Increased apoptosis  Increased circadian period len 
     Increased viability with 4OH t  Weaker migration 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cdk11b):
     cellular  embryogenesis  integument  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with CDK11B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdk11btm1Vjk for CDK11B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK11B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK11B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK11B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK11B

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD11B_HUMAN, P21127: Cytoplasm. Nucleus

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA8195233
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CDK11B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK11B About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    3Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32


    Find genes that share SuperPaths with CDK11B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CDK11B
        Cell Cycle Control of Chromosomal Replication

    1 Cell Signaling Technology (CST) Pathway for CDK11B
        Cell Cycle / Checkpoint Control

    1 Reactome Pathway for CDK11B
        Recruitment of mitotic centrosome proteins and complexes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK11B
    Interactions:

        Search GeneGlobe Interaction Network for CDK11B

    Selected Interacting proteins for CDK11B (P211271, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF3FO003031, 2, 3EBI-1298,EBI-711990 MINT-6948862 MINT-6948836 MINT-6948849 I2D: score=1 
    PAK1Q131531, 2, 3EBI-1298,EBI-1307 MINT-1771821 I2D: score=3 
    KAT7O952512, 3MINT-62237 MINT-62238 MINT-62239 MINT-62236 MINT-62240 MINT-62241 I2D: score=2 
    URM1Q9BTM92, 3MINT-63553 I2D: score=3 
    CCND3P302813I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEP10882096
    GO:0006355regulation of transcription, DNA-templated NAS9750192
    GO:0006468protein phosphorylation IDA12501247
    GO:0006915apoptotic process NAS9750192
    GO:0007067mitosis NAS1639388

    Find genes that share ontologies with CDK11B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CDK11B
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDK11B (CD11B)

    3 HMDB Compounds for CDK11B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    Find genes that share compounds with CDK11B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDK11B gene (8 alternative transcripts): 
    NM_033486.1  NM_033487.1  NM_033488.1  NM_033489.1  NM_033492.1  NM_033493.1  NM_001787.1  NM_033490.1  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513088 ENST00000341028(uc001ahc.1) ENST00000407249 ENST00000317673
    ENST00000340677 ENST00000341832(uc009vkj.2 uc010nyr.1 uc001ags.1 uc001agt.1 uc001aha.1 uc001agw.1 uc001agv.1 uc001agy.1 uc001agx.1 uc001agz.1)

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    Selected AceView cDNA sequences (see all 499):

    BF058069 BM679566 CR617963 BM761686 CA434883 BE047587 CR606630 BM977699 
    CB148088 BX646365 AA311742 AW072757 CB159795 BM510601 BU732836 C02016 
    AI066775 CB161273 BC014464 BQ717326 AW027583 AI262667 F02917 AA159745 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK11B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDK11B Expression
    About this image


    CDK11B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
    CDK11B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK11B Protein Expression

    UniProtKB/Swiss-Prot: CD11B_HUMAN, P21127
    Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK11B gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk11b5 cyclin-dependent kinase 11B   --   4 (86.73 cM) 155624854 
    chicken
    (Gallus gallus)
    Aves CDC2L16
    Gallus gallus cell division cycle 2-like 1 (PITSLR...
    84(a)
    1 → many
    21(2016536-2028646)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    93(a)
    1 → many
    GL344966.1(22-14045)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238882 Xenopus laevis transcribed sequence with strong similarity more 76.01(n)    BU916896.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA472942.12   -- 83.33(n)    CA472942.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pitslre6
    Pitslre
    39(a)
    1 → many
    3L(20764628-20770031)
    worm
    (Caenorhabditis elegans)
    Secernentea B0495.26
    ZC504.36
    Protein ZC504.3 (ZC504.3) mRNA, complete cds
    40(a)
    35(a)
    many ↔ many
    many ↔ many
    II(7699254-7702304) WBGene00015203
    X(10416637-10419751) WBGene00013917
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTK16
    Catalytic (alpha) subunit of C-terminal domain kin...
    27(a)
    1 → many
    XI(182958-184544) YKL139W
    soybean
    (Glycine max)
    eudicotyledons Gma.113112 Transcribed sequence with moderate similarity to protein more 70.84(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.118892 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.42(n)    AK111593.1 


    ENSEMBL Gene Tree for CDK11B (if available)
    TreeFam Gene Tree for CDK11B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK11B gene
    CDK11A2  CDK122  CDK102  CDK132  CDK92  
    Selected SIMAP similar genes for CDK11B using alignment to 6 protein entries:     CD11B_HUMAN (see all proteins) (see all similar genes):
    CDC2L2    CDC2L1    CDK11A    DYRK4    CDK10    CDC2
    PHKG2    CDK1    CDK3    CDK5    CDK6    DKFZp686L20222
    NEK9    CDK2    CDK7    CDK9    CDK4    CCRK

    Find genes that share paralogs with CDK11B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CDK11B
    PGOHUM00000247147


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK11B (see all 466)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446696151,2
    --841679(+) GGCCAC/TGGCGC 6 -- int10--------
    rs3688479031,2
    C--841703(+) GGCTCA/C/TGCGCT 6 -- int10--------
    rs1163066981,2
    C,F--841798(+) GCCTTC/GGCGTG 6 -- int11Minor allele frequency- G:0.05WA 118
    rs1379398481,2
    C--841828(+) AAAAAC/GAAAGA 6 -- int10--------
    rs2012685141,2
    --841925(+) CGAGG-/AGGGGG 6 -- int10--------
    rs284646841,2
    C--842017(+) ACCCTC/TCAGGC 6 -- int16Minor allele frequency- T:0.16NA CSA EA 247
    rs617749081,2
    C,F--842034(+) ACGGCC/TGCCTC 6 -- int12Minor allele frequency- T:0.21NA EA 122
    rs1917568251,2
    --842228(+) CTGGGG/TGCCGG 6 -- int10--------
    rs1823296811,2
    --842508(+) CCGGTC/TTCGGT 6 -- int10--------
    rs1873311201,2
    --842837(+) CTACCC/GACGCA 6 -- int10--------

    HapMap Linkage Disequilibrium report for CDK11B (1570603 - 1590473 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CDK11B (see all 66):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677252CNV Deletion23128226
    esv1758309CNV Deletion17803354
    esv2749696CNV Deletion23290073
    dgv3e201CNV Deletion23290073
    esv2748807CNV Deletion23290073
    esv2748696CNV Deletion23290073
    esv2748918CNV Deletion23290073
    esv1455500CNV Deletion17803354
    dgv4e201CNV Deletion23290073
    dgv2e199CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CDK11B
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK11B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176873    OMIM disorders: --

    3 diseases for CDK11B:    
    About MalaCards
    childhood endodermal sinus tumor    endodermal sinus tumor    neuroblastoma


    Find genes that share disorders with CDK11B           About GenesLikeMe

    2 Novoseek inferred disease relationships for CDK11B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 19.5 2 15344906 (1)
    tumors 0 1 9162192 (1)

    Genetic Association Database (GAD): CDK11B
    Human Genome Epidemiology (HuGE) Navigator: CDK11B (1 document)

    Export disorders for CDK11B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK11B gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with CDK11B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. (PubMed id 14511641)1, 2, 3 Mikolajczyk M.... Nelson M. (Biochem. Biophys. Res. Commun. 2003)
    2. CDK11 complexes promote pre-mRNA splicing. (PubMed id 12501247)1, 2, 9 Hu D.... Kidd V.J. (J. Biol. Chem. 2003)
    3. Structure and expression of the human p58clk-1 protein kinase chromosomal gene. (PubMed id 1639388)1, 2, 9 Eipers P.G.... Kidd V.J. (Genomics 1992)
    4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    5. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (Nat. Cell Biol. 2009)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. The cyclin-dependent kinase 11 interacts with 14-3-3 proteins. (PubMed id 15883043)1, 2 Feng Y.... Nelson M.A. (Biochem. Biophys. Res. Commun. 2005)
    9. The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. (PubMed id 12624090)1, 2 Chen S.... Gu J. (J. Biol. Chem. 2003)
    10. Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. (PubMed id 10882096)1, 2 Cornelis S....Beyaert R. (Mol. Cell 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 984 HGNC: 1729 AceView: CDC2L1andSLC35E2 Ensembl:ENSG00000248333 euGenes: HUgn984
    ECgene: CDK11B H-InvDB: CDK11B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDK11B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDK11B gene:
    Search GeneIP for patents involving CDK11B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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