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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK11A Gene

protein-coding   GIFtS: 53
GCID: GC01M001634

cyclin-dependent kinase 11A

(Previous names: cell division cycle 2-like 2, cell division cycle 2-like...)
(Previous symbols: CDC2L3, CDC2L2)
 Explore 2 diseases affiliated with
CDK11A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDK11A    

Aliases
for CDK11A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase 11A1 2     Cell Division Protein Kinase 11A2 3
CDC2L21 2 3 5     Galactosyltransferase-Associated Protein Kinase P58/GTA2 3
CDC2L31 2 3     PITSLRE Serine/Threonine-Protein Kinase CDC2L22 3
CDK11-P1101     EC 2.7.11.223 8
CDK11-P461     Cell Division Cycle 2-Like 21
CDK11-P581     PITSLRE B2
PITSLRE1 2     PITSLRE Protein Kinase Beta2
Cell Division Cycle 2-Like 2 (PITSLRE Proteins)1 2     PITSLREB3
P58GTA1     EC 2.7.118
Cell Division Cycle 2-Like Protein Kinase 22 3     

External Ids:    HGNC: 17301   Entrez Gene: 7286422   Ensembl: ENSG000000081287   OMIM: 1169515   UniProtKB: Q9UQ883   

Export aliases for CDK11A gene to outside databases

Previous GC identifer: GC01M001567


Summaries
for CDK11A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDK11A:
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be
essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the
same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of
two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been
duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN
genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell
apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the
full-length nature of only two have been determined so far. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CD11A_HUMAN, Q9UQ88
Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have
been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58
isoform may act as a negative regulator of normal cell cycle progression

Gene Wiki entry for CDK11A (CDC2L2)


Genomic Views
for CDK11A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK11A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CDK11A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

CDK11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK11A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001634:  view genomic region     (about GC identifiers)

Start:
 1,634,169 bp from pter      End:
 1,655,791 bp from pter
Size:
 21,623 bases      Orientation:
 minus strand

Proteins
for CDK11A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD11A_HUMAN, Q9UQ88 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 11A  
Size: 783 amino acids; 91362 Da
Cofactor: Magnesium
Subunit: The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the p110
isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing
CCNL1 and SFRS7
Subcellular location: Cytoplasm. Nucleus
Miscellaneous: Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at
their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated
alternative initiation of translation
Caution: Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B or
one/some of the isoforms of each
Sequence caution: Sequence=AAC95297.1; Type=Erroneous gene model prediction; Sequence=AAC95298.1; Type=Erroneous gene
model prediction; Sequence=AAC95299.1; Type=Erroneous gene model prediction; Sequence=AAC95300.1; Type=Erroneous gene
model prediction; Sequence=AAC95302.1; Type=Erroneous gene model prediction; Sequence=AAC95303.1; Type=Erroneous gene
model prediction;
Secondary accessions: O95227 O95228 O96012 Q12821 Q12853 Q12854 Q2TAJ0 Q5QPR0 Q5QPR1 Q5QPR2 Q9UBC4
Q9UBI3 Q9UEI1 Q9UEI2 Q9UP53 Q9UP54 Q9UP55 Q9UP56 Q9UQ86 Q9UQ87 Q9UQ89
Alternative splicing, Alternative initiation: 8 isoforms:  Q9UQ88-1   Q9UQ88-2   Q9UQ88-3   Q9UQ88-4   Q9UQ88-5   Q9UQ88-8   Q9UQ88-9   Q9UQ88-10   
(Produced by alternative initiation at Met-345 of isoform SV6)

Explore the universe of human proteins at neXtProt for CDK11A: NX_Q9UQ88

Post-translational modifications:

  • During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to
    • produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UQ88

    • 4/12 DME Specific Peptides for CDK11A (Q9UQ88) (see all 12)
     VKRGTSP  ILHRDLK  EQLERKR  TDEIVALK 

    CDK11A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_076916.2  NP_277071.2  

    ENSEMBL proteins: 
     ENSP00000348529   ENSP00000422149   ENSP00000384442   ENSP00000462289   ENSP00000350403  
     ENSP00000351629   ENSP00000367900   ENSP00000367905   ENSP00000423900   ENSP00000383874  
     ENSP00000367902  
    Reactome Protein details: Q9UQ88
    Human Recombinant Protein Products: 
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    Novus Biologicals CDK11A Protein
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDK11A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--


    CDK11A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CDK11A

    Protein Domains /
    Families
    for CDK11A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDK11A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQ88

    ProtoNet protein and cluster: Q9UQ88

    UniProtKB/Swiss-Prot: CD11A_HUMAN, Q9UQ88
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CDK11A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD11A_HUMAN, Q9UQ88
    Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have
    been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58
    isoform may act as a negative regulator of normal cell cycle progression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylation at Thr-436 or Tyr-437 inactivates the enzyme, while phosphorylation at Thr-583
    activates it (By similarity)
    Induction: The p58 isoform is specifically induced in G2/M phase of the cell cycle

    Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity NAS9750192
    GO:0004674protein serine/threonine kinase activity IDA12501247
    GO:0004693cyclin-dependent protein kinase activity IEA--
    GO:0005524ATP binding IDA12501247


    CDK11A for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CDK11A:
     Decreased viability of wild-ty  Increased cell death in HCC-19  Increased viability with 4OH t 


    Pathways & Interactions
    for CDK11A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Recruitment of mitotic centrosome proteins and complexes
    		Centrosome maturation1.00
    		G2/M Transition0.83
    		Recruitment of mitotic centrosome proteins and complexes1.00
    		Mitotic G2-G2/M phases0.81
    2Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for CDK11A (see all 6)
        Centrosome maturation
    G2/M Transition
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    Mitotic G2-G2/M phases



    CDK11A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK11A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for CDK11A (Q9UQ882, 3 ENSP000003844424) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKIV2LQ154773, ENSP000003645434I2D: score=2 STRING: ENSP00000364543
    EIF3FO003033, ENSP000003100404I2D: score=1 STRING: ENSP00000310040
    PAK1Q131533, ENSP000002785684I2D: score=1 STRING: ENSP00000278568
    CCNL1Q9UK583, ENSP000002959264I2D: score=1 STRING: ENSP00000295926
    CCNL2Q96S943, ENSP000003836114I2D: score=1 STRING: ENSP00000383611
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEP10882096
    GO:0001824blastocyst development ----
    GO:0006355regulation of transcription, DNA-dependent NAS9750192
    GO:0006468protein phosphorylation IDA12501247
    GO:0006915apoptotic process NAS9750192


    CDK11A for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK11A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CDK11A

    3 HMDB Compounds for CDK11A    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about CDK11A / CD11A 

    Transcripts
    for CDK11A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDK11A gene (5 alternative transcripts): 
    NM_024011.2  NM_033529.2  NM_033527.1  NM_033532.1  NM_033534.1  

    Unigene Cluster for CDK11A:

    Cyclin-dependent kinase 11A
    Hs.651228  [show with all ESTs]
    Unigene Representative Sequence: NM_024011
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000356200(uc001ahj.4 uc009vkp.3 uc009vkq.3 uc009vkr.3 uc009vks.3)
    ENST00000463652 ENST00000356937 ENST00000509982(uc001aht.1) ENST00000404249
    ENST00000460465 ENST00000357760(uc009vkt.1) ENST00000358779 ENST00000378633(uc009vku.1)
    ENST00000378638(uc010nys.2 uc010nyt.1 uc010nyu.1 uc009vkv.1)
    ENST00000478901 ENST00000468397 ENST00000491311 ENST00000495016 ENST00000468800
    ENST00000464748 ENST00000489300 ENST00000492390

    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF067519.1 AF067520.1 AF067521.1 AF067522.1 AF067524.1 AF067526.1 AF067527.1 AF067528.1 
    AF067529.1 BC014464.1 BC028187.1 BC054019.1 BC094827.1 BC104661.1 BC110905.1 U04819.1 
    U07704.1 U07705.1 

    24/37 DOTS entries (see all 37):

    DT.100887081  DT.100887080  DT.101985235  DT.92453672  DT.95224393  DT.92453671  DT.40308783  DT.95224500 
    DT.100887093  DT.121399053  DT.121399105  DT.92453679  DT.101961048  DT.95224492  DT.100741681  DT.75133401 
    DT.121399172  DT.121399213  DT.40105999  DT.91946997  DT.95213021  DT.99996119  DT.100044908  DT.100887076 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for CDK11A (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a ·
    SP1:                                                                                                                          -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                    -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                      -                                   -                                 

    ExUns: 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b · 23c
    SP1:        -                 -                                                                                 
    SP2:                          -                       -                                                         
    SP3:                                                  -                             -                           
    SP4:  -     -     -     -     -     -     -     -     -     -     -                 -                           
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for CDK11A

    Expression
    for CDK11A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK11A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTGTTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CDK11A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK11A

    SOURCE GeneReport for Unigene cluster: Hs.651228

    UniProtKB/Swiss-Prot: CD11A_HUMAN, Q9UQ88
    Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution

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    Orthologs
    for CDK11A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK11A gene from 7/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDC2L11 cell division cycle 2-like 1 (PITSLRE proteins) 77.62(n)
    92.31(a)    		   419406  NM_001030871.2  NP_001026042.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CDK11A6
    		 --
    		 91(a)
    		 1 → many
    		 GL344966.1(2083-13920)
    zebrafish
    (Danio rerio)    		 Actinopterygii cdk11b1 cyclin-dependent kinase 11B 73.2(n)
    78.32(a)    		   494103  NM_001008646.1  NP_001008646.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pitslre1 CG4268-PA 54.33(n)
    50.82(a)    		   40292  NM_168869.2  NP_730563.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea B0495.21 Protein B0495.2 46.93(n)
    43.57(a)    		   174244  NM_063216.4  NP_495617.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G675801 protein kinase-like protein 55.73(n)
    56.61(a)    		   843079  NM_105425.4  NP_176925.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g04880001 hypothetical protein 49.57(n)
    45.97(a)    		   4336224  NM_001059682.1  NP_001053147.1 


    ENSEMBL Gene Tree for CDK11A (if available)
    TreeFam Gene Tree for CDK11A (if available) 

    Paralogs
    for CDK11A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK11A gene
    CDK11B1 2  CDK102  
    18/34 SIMAP similar genes for CDK11A using alignment to 8 protein entries:     CD11A_HUMAN (see all proteins) (see all similar genes):
    CDC2L2    CDC2L1    CDK11B    CDK10    CDK1    CDK2
    CDK3    CDK5    CDK6    CDK7    CDK9    CDK20
    CDK4    CDK17    DKFZp686O0215    MAK    CDK8    PCTK1

    CDK11A for paralogs           About GeneDecksing



    Genomic Variants
    for CDK11A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/562 NCBI SNPs in CDK11A are shown (see all 562)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2010040061,2
    		Cother1635335(+) TCCCCG/AAAGAT 4 /F syn11Minor allele frequency- A:0.00EU 579
    rs2012440011,2
    		F--1634959(+) CCGAAG/ACGCTT 4 /R syn11Minor allele frequency- A:0.00EU 500
    rs8745161,2
    		C,F,O,--1635004(+) ATCTTC/TTTGAC 4 K syn18Minor allele frequency- T:0.45NA EA EU 771
    rs10598111,2
    		C,F--1635011(+) TGACTA/GCTGGG 4 A V mis16Minor allele frequency- G:0.18NA MN NS EU 949
    rs11369781,2
    		C,F,--1635022(+) AGCTCA/GCTGTA 4 S syn13Minor allele frequency- G:0.00NA EU 505
    rs11369791,2
    		C,--1635049(+) TCACTG/AGGGGT 4 /P syn11Minor allele frequency- A:0.00NA 2
    rs1857589131,2
    		--1635052(+) CTGGGG/TGTCCC 4 T syn10--------
    rs11369801,2
    		--1635061(+) CCCAGC/ATCCTG 4 /E /D mis12Minor allele frequency- A:0.00NA 4
    rs114885901,2
    		C,F,--1635108(+) CCACAG/ATGTTG 2 -- int11Minor allele frequency- A:0.04EU 515
    rs114860261,2
    		--1635193(+) ACCTGC/TGCGCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for CDK11A (1634169 - 1655791 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for CDK11A
         11 CNVs: 2042 22925 38832 2295 30362 3276 0002 60788 31596 84001 63709
         1 Indel: 11373
    Human Gene Mutation Database (HGMD): CDK11A

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    Disorders / Diseases
    for CDK11A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDK11A for disorders           About GeneDecksing

    OMIM gene information: 116951    OMIM disorders: --

    2 diseases for CDK11A:    About MalaCards
    neuroblastoma    breast cancer

    Human Genome Epidemiology (HuGE) Navigator: CDK11A (2 documents)

    Export disorders for CDK11A gene to outside databases

    Publications
    for CDK11A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK11A gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with CDK11A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PubMed id 9750192)1, 2, 3 Gururajan R....Kidd V.J. (1998)
    2. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. (PubMed id 12624090)1, 2 Chen S.... Gu J. (2003)
    5. CDK11 complexes promote pre-mRNA splicing. (PubMed id 12501247)1, 2 Hu D.... Kidd V.J. (2003)
    6. Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. (PubMed id 10882096)1, 2 Cornelis S....Beyaert R. (2000)
    7. Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. (PubMed id 7920654)1, 3 Lahti J.M....Kidd V.J. (1994)
    8. Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms. (PubMed id 8195233)1, 2 Xiang J.... Kidd V.J. (1994)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for CDK11A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing CDK11A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 728642 HGNC: 1730 Ensembl:ENSG00000008128 euGenes: HUgn728642 ECgene: CDK11A
    H-InvDB: CDK11A

    Other Databases showing CDK11A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDK11A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK11A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CDK11A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDK11A gene:
    Search GeneIP for patents involving CDK11A

    GeneCards and IP:
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