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Aliases for CDK11A Gene

Aliases for CDK11A Gene

  • Cyclin-Dependent Kinase 11A 2 3 5
  • Galactosyltransferase-Associated Protein Kinase P58/GTA 3 4
  • Cell Division Cycle 2-Like 2 (PITSLRE Proteins) 2 3
  • PITSLRE Serine/Threonine-Protein Kinase CDC2L2 3 4
  • Cell Division Cycle 2-Like Protein Kinase 2 3 4
  • Cell Division Protein Kinase 11A 3 4
  • EC 2.7.11.22 4 63
  • CDC2L2 3 4
  • CDC2L3 3 4
  • Cell Division Cycle 2-Like 2 2
  • PITSLRE Protein Kinase Beta 3
  • CDK11-P110 3
  • PITSLRE B 3
  • CDK11-P46 3
  • CDK11-P58 3
  • EC 2.7.11 63
  • PITSLREB 4
  • PITSLRE 3
  • P58GTA 3

External Ids for CDK11A Gene

Previous HGNC Symbols for CDK11A Gene

  • CDC2L3
  • CDC2L2

Previous GeneCards Identifiers for CDK11A Gene

  • GC01M001567
  • GC01M001634

Summaries for CDK11A Gene

Entrez Gene Summary for CDK11A Gene

  • This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

GeneCards Summary for CDK11A Gene

CDK11A (Cyclin-Dependent Kinase 11A) is a Protein Coding gene. Diseases associated with CDK11A include Neuroblastoma. Among its related pathways are Cell Cycle, Mitotic and Regulation of PLK1 Activity at G2/M Transition. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK4.

UniProtKB/Swiss-Prot for CDK11A Gene

  • Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.

Gene Wiki entry for CDK11A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK11A Gene

Genomics for CDK11A Gene

Regulatory Elements for CDK11A Gene

Enhancers for CDK11A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDK11A on UCSC Golden Path with GeneCards custom track

Promoters for CDK11A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDK11A on UCSC Golden Path with GeneCards custom track

Genomic Location for CDK11A Gene

Chromosome:
1
Start:
1,702,730 bp from pter
End:
1,724,352 bp from pter
Size:
21,623 bases
Orientation:
Minus strand

Genomic View for CDK11A Gene

Genes around CDK11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK11A Gene

Proteins for CDK11A Gene

  • Protein details for CDK11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ88-CD11A_HUMAN
    Recommended name:
    Cyclin-dependent kinase 11A
    Protein Accession:
    Q9UQ88
    Secondary Accessions:
    • O95227
    • O95228
    • O96012
    • Q12821
    • Q12853
    • Q12854
    • Q2TAJ0
    • Q5QPR0
    • Q5QPR1
    • Q5QPR2
    • Q9UBC4
    • Q9UBI3
    • Q9UEI1
    • Q9UEI2
    • Q9UP53
    • Q9UP54
    • Q9UP55
    • Q9UP56
    • Q9UQ86
    • Q9UQ87
    • Q9UQ89

    Protein attributes for CDK11A Gene

    Size:
    783 amino acids
    Molecular mass:
    91362 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the p110 isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7.
    Miscellaneous:
    • Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.
    SequenceCaution:
    • Sequence=AAC95297.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC95298.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC95299.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC95300.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC95302.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC95303.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK11A Gene

neXtProt entry for CDK11A Gene

Proteomics data for CDK11A Gene at MOPED

Post-translational modifications for CDK11A Gene

  • During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CDK11A Gene

Gene Families for CDK11A Gene

Protein Domains for CDK11A Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQ88

UniProtKB/Swiss-Prot:

CD11A_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK11A: view

Function for CDK11A Gene

Molecular function for CDK11A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation at Thr-436 or Tyr-437 inactivates the enzyme, while phosphorylation at Thr-583 activates it.
UniProtKB/Swiss-Prot Function:
Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
UniProtKB/Swiss-Prot Induction:
The p58 isoform is specifically induced in G2/M phase of the cell cycle.

Enzyme Numbers (IUBMB) for CDK11A Gene

genes like me logo Genes that share phenotypes with CDK11A: view

Animal Models for CDK11A Gene

MGI Knock Outs for CDK11A:

Animal Model Products

miRNA for CDK11A Gene

miRTarBase miRNAs that target CDK11A

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDK11A Gene

Localization for CDK11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK11A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK11A Gene COMPARTMENTS Subcellular localization image for CDK11A gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for CDK11A Gene

Pathways & Interactions for CDK11A Gene

genes like me logo Genes that share pathways with CDK11A: view

Pathways by source for CDK11A Gene

1 GeneTex pathway for CDK11A Gene

SIGNOR curated interactions for CDK11A Gene

Activates:

Gene Ontology (GO) - Biological Process for CDK11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 12501247
GO:0006915 apoptotic process NAS 9750192
genes like me logo Genes that share ontologies with CDK11A: view

Drugs & Compounds for CDK11A Gene

(2) Drugs for CDK11A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for CDK11A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK11A: view

Transcripts for CDK11A Gene

mRNA/cDNA for CDK11A Gene

(7) REFSEQ mRNAs :
(18) Additional mRNA sequences :
(23) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDK11A Gene

Cyclin-dependent kinase 11A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK11A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a ·
SP1: -
SP2:
SP3:
SP4: - - - - - - - - - - - - - - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14: -
SP15: - -

ExUns: 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b · 23c
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8: -
SP9: - -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CDK11A Gene

GeneLoc Exon Structure for
CDK11A
ECgene alternative splicing isoforms for
CDK11A

Expression for CDK11A Gene

mRNA expression in normal human tissues for CDK11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDK11A Gene

This gene is overexpressed in Pancreas (31.5), Lung (22.2), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK11A Gene



SOURCE GeneReport for Unigene cluster for CDK11A Gene Hs.651228

mRNA Expression by UniProt/SwissProt for CDK11A Gene

Q9UQ88-CD11A_HUMAN
Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
genes like me logo Genes that share expression patterns with CDK11A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for CDK11A Gene

Orthologs for CDK11A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK11A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDC2L1 35
  • 87.43 (n)
  • 94.28 (a)
CDC2L1 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CDK11B 35
  • 85.77 (n)
  • 94.1 (a)
-- 36
  • 90 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cdk11b 35
  • 84.27 (n)
  • 92.18 (a)
Cdk11b 16
Cdk11b 36
  • 95 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CDK11B 35
  • 97.95 (n)
  • 97.83 (a)
rat
(Rattus norvegicus)
Mammalia Cdk11b 35
  • 85 (n)
  • 92.56 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves CDC2L1 35
  • 76.77 (n)
  • 93.24 (a)
CDC2L1 36
  • 92 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk11b 35
  • 73.16 (n)
  • 89.33 (a)
zebrafish
(Danio rerio)
Actinopterygii cdk11b 35
  • 80.67 (n)
  • 87.7 (a)
cdk11b 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pitslre 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.2 36
  • 41 (a)
ManyToMany
ZC504.3 36
  • 36 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 36
  • 27 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07880 35
  • 53.04 (n)
  • 47.51 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppk23 35
  • 50.26 (n)
  • 47.63 (a)
Species with no ortholog for CDK11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK11A Gene

ENSEMBL:
Gene Tree for CDK11A (if available)
TreeFam:
Gene Tree for CDK11A (if available)

Paralogs for CDK11A Gene

Paralogs for CDK11A Gene

genes like me logo Genes that share paralogs with CDK11A: view

Variants for CDK11A Gene

Sequence variations from dbSNP and Humsavar for CDK11A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1059831 - 1,719,406(+) TTTCC(A/G)AGACA reference, missense
rs1059828 - 1,707,458(+) TGGGC(A/C/G)ACAGG reference, missense
rs17424353 - 1,721,654(-) ATCAC(C/G/T)GCATG reference, missense
VAR_060153 -
VAR_062200 -

Structural Variations from Database of Genomic Variants (DGV) for CDK11A Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
dgv9e1 CNV Complex 17122850
dgv43n71 CNV Loss 21882294
nsv871954 CNV Loss 21882294
nsv871540 CNV Gain 21882294
dgv45n71 CNV Loss 21882294
nsv870847 CNV Loss 21882294
dgv47n71 CNV Loss 21882294
nsv871583 CNV Loss 21882294
esv27786 CNV Gain 19812545
esv2748696 CNV Deletion 23290073
nsv871749 CNV Gain+Loss 21882294
nsv870598 CNV Gain 21882294
dgv2e199 CNV Deletion 23128226
dgv3n67 CNV Gain 20364138
dgv49n71 CNV Loss 21882294
dgv50n71 CNV Gain 21882294
nsv871030 CNV Gain 21882294
dgv51n71 CNV Loss 21882294
dgv10e1 CNV Complex 17122850
nsv482957 CNV Loss 15286789
dgv52n71 CNV Loss 21882294
dgv53n71 CNV Gain 21882294
nsv871560 CNV Loss 21882294
nsv442858 CNV CNV 18776908
nsv436343 CNV Deletion 17901297
nsv834091 CNV Loss 17160897
nsv482168 CNV Gain 20164927
nsv822475 CNV Gain 20364138
nsv822586 CNV Gain 20364138
nsv822697 CNV Loss 20364138
nsv871903 CNV Gain+Loss 21882294
nsv871121 CNV Gain 21882294
essv725 CNV CNV 17122850
nsv822809 CNV Loss 20364138
nsv509368 CNV Insertion 20534489
esv2748807 CNV Deletion 23290073
nsv436733 CNV Insertion 17901297
esv2748918 CNV Deletion 23290073
nsv159838 CNV Loss 16902084
esv988165 CNV Deletion 20482838
esv1455500 CNV Deletion 17803354
nsv160496 CNV Loss 16902084
dgv3e201 CNV Deletion 23290073
dgv4e201 CNV Deletion 23290073
esv2749585 CNV Deletion 23290073
nsv160062 CNV Loss 16902084
esv2749696 CNV Deletion 23290073
esv6106 CNV Loss 19470904
nsv160158 CNV Insertion 16902084
esv2668621 CNV Deletion 23128226

Variation tolerance for CDK11A Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.16; 97.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK11A Gene

Human Gene Mutation Database (HGMD)
CDK11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK11A Gene

Disorders for CDK11A Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDK11A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDK11A

Genetic Association Database (GAD)
CDK11A
Human Genome Epidemiology (HuGE) Navigator
CDK11A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK11A
genes like me logo Genes that share disorders with CDK11A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK11A Gene

Publications for CDK11A Gene

  1. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PMID: 9750192) Gururajan R. … Kidd V.J. (Genome Res. 1998) 2 3 4 67
  2. Cyclin-dependent kinases: a family portrait. (PMID: 19884882) Malumbres M. … Wolgemuth D.J. (Nat. Cell Biol. 2009) 2 3
  3. Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. (PMID: 7920654) Lahti J.M. … Kidd V.J. (Nat. Genet. 1994) 2 3
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3

Products for CDK11A Gene

Sources for CDK11A Gene

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