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CDK11A Gene

protein-coding   GIFtS: 58
GCID: GC01M001634

Cyclin-Dependent Kinase 11A

(Previous names: cell division cycle 2-like 2, cell division cycle 2-like...)
(Previous symbols: CDC2L3, CDC2L2)
  See CDK11A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 11A1 2     CDK11-p1102
CDC2L21 2 3 5     CDK11-p462
CDC2L31 2 3     CDK11-p582
Cell Division Cycle 2-Like 2 (PITSLRE Proteins)1 2     PITSLRE2
Cell Division Cycle 2-Like Protein Kinase 22 3     p58GTA2
Cell Division Protein Kinase 11A2 3     PITSLRE B2
Galactosyltransferase-Associated Protein Kinase P58/GTA2 3     PITSLRE Protein Kinase Beta2
PITSLRE Serine/Threonine-Protein Kinase CDC2L22 3     PITSLREB3
EC 2.7.11.223 8     EC 2.7.118
Cell Division Cycle 2-Like 21     

External Ids:    HGNC: 17301   Entrez Gene: 7286422   Ensembl: ENSG000000081287   OMIM: 1169515   UniProtKB: Q9UQ883   

Export aliases for CDK11A gene to outside databases

Previous GC identifer: GC01M001567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK11A Gene:
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be
essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene
in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22,
consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region
that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma
with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was
demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have
been found for this gene, but the full-length nature of only two have been determined so far. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CDK11A Gene:
CDK11A (cyclin-dependent kinase 11A) is a protein-coding gene. Diseases associated with CDK11A include neuroblastoma. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK12.

UniProtKB/Swiss-Prot: CD11A_HUMAN, Q9UQ88
Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms
have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein
SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression

Gene Wiki entry for CDK11A (CDC2L2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CDK11A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CDK11A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK11A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

CDK11A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK11A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001634:  view genomic region     (about GC identifiers)

Start:
1,634,169 bp from pter      End:
1,655,791 bp from pter
Size:
21,623 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CD11A_HUMAN, Q9UQ88 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 11A  
Size: 783 amino acids; 91362 Da
Cofactor: Magnesium
Subunit: The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the
p110 isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes
containing CCNL1 and SFRS7
Miscellaneous: Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain
at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated
alternative initiation of translation
Caution: Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B
or one/some of the isoforms of each
Sequence caution: Sequence=AAC95297.1; Type=Erroneous gene model prediction; Sequence=AAC95298.1; Type=Erroneous
gene model prediction; Sequence=AAC95299.1; Type=Erroneous gene model prediction; Sequence=AAC95300.1;
Type=Erroneous gene model prediction; Sequence=AAC95302.1; Type=Erroneous gene model prediction;
Sequence=AAC95303.1; Type=Erroneous gene model prediction;
Secondary accessions: O95227 O95228 O96012 Q12821 Q12853 Q12854 Q2TAJ0 Q5QPR0 Q5QPR1 Q5QPR2
Q9UBC4 Q9UBI3 Q9UEI1 Q9UEI2 Q9UP53 Q9UP54 Q9UP55 Q9UP56 Q9UQ86 Q9UQ87 Q9UQ89
Alternative splicing, Alternative initiation: 8 isoforms:  Q9UQ88-1   Q9UQ88-2   Q9UQ88-3   Q9UQ88-4   Q9UQ88-5   Q9UQ88-8   Q9UQ88-9   Q9UQ88-10   
(Produced by alternative initiation at Met-345 of isoform SV6)

Explore the universe of human proteins at neXtProt for CDK11A: NX_Q9UQ88

Explore proteomics data for CDK11A at MOPED

Post-translational modifications: 

  • During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to
    produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins1
  • Ubiquitination2 at Lys661, Lys707
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK11A (Q9UQ88) (see all 12)
     VKRGTSP  ILHRDLK  EQLERKR  TDEIVALK 


    See CDK11A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_076916.2  NP_277071.2  

    ENSEMBL proteins: 
     ENSP00000348529   ENSP00000367905   ENSP00000422149   ENSP00000384442   ENSP00000462289  
     ENSP00000350403   ENSP00000351629   ENSP00000367900   ENSP00000423900   ENSP00000383874  
     ENSP00000367902  
    Reactome Protein details: Q9UQ88

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    Cloud-Clone Corp. Proteins for CDK11A

     
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    antibodies-online proteins for CDK11A (3 products) 

     
    antibodies-online peptides for CDK11A

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 11A
    PITSLRE subfamily

    4 InterPro protein domains:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQ88

    ProtoNet protein and cluster: Q9UQ88

    UniProtKB/Swiss-Prot: CD11A_HUMAN, Q9UQ88
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDK11A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD11A_HUMAN, Q9UQ88
    Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms
    have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein
    SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Phosphorylation at Thr-436 or Tyr-437 inactivates the enzyme, while phosphorylation at Thr-583
    activates it (By similarity)
    Induction: The p58 isoform is specifically induced in G2/M phase of the cell cycle

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity NAS9750192
    GO:0004674protein serine/threonine kinase activity IDA12501247
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IDA12501247
         
    Find genes that share ontologies with CDK11A           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDK11A:
     Decreased viability of wild-ty  Increased cell death in HCC-19  Increased viability with 4OH t 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CDK11A

    miRNA
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    miRTarBase miRNAs that target CDK11A:
    hsa-mir-92a-3p (MIRT049054), hsa-mir-877-3p (MIRT037092)

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    hsa-miR-1283
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD11A_HUMAN, Q9UQ88: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with CDK11A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK11A About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90


    Find genes that share SuperPaths with CDK11A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CDK11A
        Recruitment of mitotic centrosome proteins and complexes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK11A
    Interactions:

        Search GeneGlobe Interaction Network for CDK11A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK11A (Q9UQ882, 3 ENSP000003844424) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000223493Q154773, ENSP000004123104I2D: score=2 STRING: ENSP00000412310
    SKIV2LQ154773, ENSP000003645434I2D: score=2 STRING: ENSP00000364543
    ENSG00000206353Q154773I2D: score=2 
    ENSG00000225737Q154773I2D: score=2 
    ENSG00000228896Q154773I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEP10882096
    GO:0006355regulation of transcription, DNA-templated NAS9750192
    GO:0006468protein phosphorylation IDA12501247
    GO:0006915apoptotic process NAS9750192
    GO:0007067mitosis NAS1639388

    Find genes that share ontologies with CDK11A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CDK11A (CD11A)

    3 HMDB Compounds for CDK11A    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDK11A gene (5 alternative transcripts): 
    NM_024011.2  NM_033529.2  NM_033527.1  NM_033532.1  NM_033534.1  

    Unigene Cluster for CDK11A:

    Cyclin-dependent kinase 11A
    Hs.651228  [show with all ESTs]
    Unigene Representative Sequence: NM_024011
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000356200(uc001ahj.4 uc009vkp.3 uc009vkq.3 uc009vkr.3 uc009vks.3)
    ENST00000463652 ENST00000356937 ENST00000378638(uc010nys.2 uc010nyt.1 uc010nyu.1 uc009vkv.1)
    ENST00000509982(uc001aht.1) ENST00000404249 ENST00000460465 ENST00000357760(uc009vkt.1)
    ENST00000358779 ENST00000378633(uc009vku.1) ENST00000478901 ENST00000468397
    ENST00000491311 ENST00000495016 ENST00000468800 ENST00000464748 ENST00000489300
    ENST00000492390
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    Additional mRNA sequence: 

    AF067519.1 AF067520.1 AF067521.1 AF067522.1 AF067524.1 AF067526.1 AF067527.1 AF067528.1 
    AF067529.1 BC014464.1 BC028187.1 BC054019.1 BC094827.1 BC104661.1 BC110905.1 U04819.1 
    U07704.1 U07705.1 

    Selected DOTS entries (see all 37):

    DT.100887081  DT.100887080  DT.101985235  DT.92453672  DT.95224393  DT.92453671  DT.40308783  DT.95224500 
    DT.100887093  DT.121399053  DT.121399105  DT.92453679  DT.101961048  DT.95224492  DT.100741681  DT.75133401 
    DT.121399172  DT.121399213  DT.40105999  DT.91946997  DT.95213021  DT.99996119  DT.100044908  DT.100887076 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK11A (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a ·
    SP1:                                                                                                                          -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                    -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                                                                      -                                   -                                 

    ExUns: 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b · 23c
    SP1:        -                 -                                                                                 
    SP2:                          -                       -                                                         
    SP3:                                                  -                             -                           
    SP4:  -     -     -     -     -     -     -     -     -     -     -                 -                           
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for CDK11A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK11A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGTTTTT
    CDK11A Expression
    About this image

    CDK11A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK11A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.651228

    UniProtKB/Swiss-Prot: CD11A_HUMAN, Q9UQ88
    Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK11A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk11b1 cyclin-dependent kinase 11B 84.27(n)
    92.18(a)
      12537  NM_007661.3  NP_031687.2 
    chicken
    (Gallus gallus)
    Aves CDC2L11 cell division cycle 2-like 1 (PITSLRE proteins) 76.77(n)
    93.24(a)
      419406  NM_001030871.2  NP_001026042.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    91(a)
    1 → many
    GL344966.1(22-14045)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdk11b1 cyclin-dependent kinase 11B 73.16(n)
    89.33(a)
      549737  NM_001016983.2  NP_001016983.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk11b1 cyclin-dependent kinase 11B 80.67(n)
    87.7(a)
      494103  NM_001008646.1  NP_001008646.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pitslre6
    Pitslre
    40(a)
    1 → many
    3L(20764628-20770031)
    worm
    (Caenorhabditis elegans)
    Secernentea B0495.26
    ZC504.36
    Protein ZC504.3 (ZC504.3) mRNA, complete cds
    41(a)
    36(a)
    many ↔ many
    many ↔ many
    II(7699254-7702304) WBGene00015203
    X(10416637-10419751) WBGene00013917
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTK16
    Catalytic (alpha) subunit of C-terminal domain kin...
    27(a)
    1 → many
    XI(182958-184544) YKL139W


    ENSEMBL Gene Tree for CDK11A (if available)
    TreeFam Gene Tree for CDK11A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK11A gene
    CDK122  CDK102  CDK132  CDK92  CDK11B2  
    Selected SIMAP similar genes for CDK11A using alignment to 8 protein entries:     CD11A_HUMAN (see all proteins) (see all similar genes):
    CDC2L2    CDC2L1    CDK11B    CDK10    CDK1    CDK2
    CDK3    CDK5    CDK6    CDK7    CDK9    CDK20
    CDK4    CDK17    DKFZp686O0215    MAK    CDK8    MAPK1

    Find genes that share paralogs with CDK11A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK11A (see all 780)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2010040061,2
    Cuntested11635335(+) TCCCCG/AAAGAT 4 /F syn11Minor allele frequency- A:0.00EU 579
    rs3742810161,2
    C--1634894(+) CCGCCA/GCCCGG 2 -- int10--------
    rs2012440011,2
    F--1634959(+) CCGAAG/ACGCTT 4 /R syn11Minor allele frequency- A:0.00EU 500
    rs8745161,2
    C,F,O--1635004(+) ATCTTC/TTTGAC 4 K syn18Minor allele frequency- T:0.45NA EA EU 771
    rs10598111,2,,4
    C,F--1635011(+) TGACTA/GCTGGG 4 A V mis16Minor allele frequency- G:0.18NA MN NS EU 949
    rs11369781,2
    C,F--1635022(+) AGCTCA/GCTGTA 4 S syn13Minor allele frequency- G:0.00NA EU 505
    rs11369791,2
    C--1635049(+) TCACTG/AGGGGT 4 /P syn11Minor allele frequency- A:0.00NA 2
    rs1857589131,2
    --1635052(+) CTGGGG/TGTCCC 4 T syn10--------
    rs11369801,2
    --1635061(+) CCCAGC/ATCCTG 4 /E /D mis12Minor allele frequency- A:0.00NA 4
    rs114885901,2
    C,F--1635108(+) CCACAG/ATGTTG 2 -- int11Minor allele frequency- A:0.04EU 515

    HapMap Linkage Disequilibrium report for CDK11A (1634169 - 1655791 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CDK11A (see all 56):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748807CNV Deletion23290073
    esv2748696CNV Deletion23290073
    esv2748918CNV Deletion23290073
    esv1455500CNV Deletion17803354
    dgv4e201CNV Deletion23290073
    dgv2e199CNV Deletion23128226
    esv2749696CNV Deletion23290073
    nsv436343CNV Deletion17901297
    dgv3e201CNV Deletion23290073
    esv2668621CNV Deletion23128226

    Human Gene Mutation Database (HGMD): CDK11A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK11A
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK11A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116951    OMIM disorders: --

    1 disease for CDK11A:    
    About MalaCards
    neuroblastoma


    Find genes that share disorders with CDK11A           About GenesLikeMe

    Genetic Association Database (GAD): CDK11A
    Human Genome Epidemiology (HuGE) Navigator: CDK11A (2 documents)

    Export disorders for CDK11A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK11A gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with CDK11A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PubMed id 9750192)1, 2, 3 Gururajan R.... Kidd V.J. (Genome Res. 1998)
    2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    3. Cyclin-dependent kinases: a family portrait. (PubMed id 19884882)1, 3 Malumbres M....Wolgemuth D.J. (Nat. Cell Biol. 2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis. (PubMed id 12624090)1, 2 Chen S.... Gu J. (J. Biol. Chem. 2003)
    6. CDK11 complexes promote pre-mRNA splicing. (PubMed id 12501247)1, 2 Hu D.... Kidd V.J. (J. Biol. Chem. 2003)
    7. Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. (PubMed id 10882096)1, 2 Cornelis S....Beyaert R. (Mol. Cell 2000)
    8. Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. (PubMed id 7920654)1, 3 Lahti J.M....Kidd V.J. (Nat. Genet. 1994)
    9. Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms. (PubMed id 8195233)1, 2 Xiang J.... Kidd V.J. (J. Biol. Chem. 1994)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 728642 HGNC: 1730 Ensembl:ENSG00000008128 euGenes: HUgn728642 ECgene: CDK11A
    H-InvDB: CDK11A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDK11A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK11A gene:
    Search GeneIP for patents involving CDK11A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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