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Aliases for CDK11A Gene

Aliases for CDK11A Gene

  • Cyclin-Dependent Kinase 11A 2 3
  • CDC2L2 3 4 6
  • Galactosyltransferase-Associated Protein Kinase P58/GTA 3 4
  • Cell Division Cycle 2-Like 2 (PITSLRE Proteins) 2 3
  • PITSLRE Serine/Threonine-Protein Kinase CDC2L2 3 4
  • Cell Division Cycle 2-Like Protein Kinase 2 3 4
  • Cell Division Protein Kinase 11A 3 4
  • EC 2.7.11.22 4 63
  • CDC2L3 3 4
  • Cell Division Cycle 2-Like 2 2
  • PITSLRE Protein Kinase Beta 3
  • CDK11-P110 3
  • PITSLRE B 3
  • CDK11-P46 3
  • CDK11-P58 3
  • EC 2.7.11 63
  • PITSLREB 4
  • PITSLRE 3
  • P58GTA 3

External Ids for CDK11A Gene

Previous HGNC Symbols for CDK11A Gene

  • CDC2L3
  • CDC2L2

Previous GeneCards Identifiers for CDK11A Gene

  • GC01M001567
  • GC01M001634

Summaries for CDK11A Gene

Entrez Gene Summary for CDK11A Gene

  • This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK11A Gene

CDK11A (Cyclin-Dependent Kinase 11A) is a Protein Coding gene. Diseases associated with CDK11A include neuroblastoma. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK12.

UniProtKB/Swiss-Prot for CDK11A Gene

  • Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.

Gene Wiki entry for CDK11A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK11A Gene

Genomics for CDK11A Gene

Genomic Location for CDK11A Gene

Start:
1,702,730 bp from pter
End:
1,724,352 bp from pter
Size:
21,623 bases
Orientation:
Minus strand

Genomic View for CDK11A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK11A Gene

No data available for Regulatory Elements for CDK11A Gene

Proteins for CDK11A Gene

  • Protein details for CDK11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ88-CD11A_HUMAN
    Recommended name:
    Cyclin-dependent kinase 11A
    Protein Accession:
    Q9UQ88
    Secondary Accessions:
    • O95227
    • O95228
    • O96012
    • Q12821
    • Q12853
    • Q12854
    • Q2TAJ0
    • Q5QPR0
    • Q5QPR1
    • Q5QPR2
    • Q9UBC4
    • Q9UBI3
    • Q9UEI1
    • Q9UEI2
    • Q9UP53
    • Q9UP54
    • Q9UP55
    • Q9UP56
    • Q9UQ86
    • Q9UQ87
    • Q9UQ89

    Protein attributes for CDK11A Gene

    Size:
    783 amino acids
    Molecular mass:
    91362 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the p110 isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7.
    Miscellaneous:
    • Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation
    SequenceCaution:
    • Sequence=AAC95297.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC95298.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC95299.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC95300.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC95302.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC95303.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CDK11A Gene

neXtProt entry for CDK11A Gene

Proteomics data for CDK11A Gene at MOPED

Post-translational modifications for CDK11A Gene

  • During apoptosis, induced by Fas or tumor necrosis factor, specific CKD11 p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the CDK11 proteins
  • Ubiquitination at Lys661 and Lys707
  • Modification sites at PhosphoSitePlus

Domains for CDK11A Gene

Gene Families for CDK11A Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

Protein Domains for CDK11A Gene

Suggested Antigen Peptide Sequences for CDK11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UQ88

UniProtKB/Swiss-Prot:

CD11A_HUMAN :
  • Q9UQ88
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK11A: view

Function for CDK11A Gene

Molecular function for CDK11A Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Phosphorylation at Thr-436 or Tyr-437 inactivates the enzyme, while phosphorylation at Thr-583 activates it.
UniProtKB/Swiss-Prot Function: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
UniProtKB/Swiss-Prot Induction: The p58 isoform is specifically induced in G2/M phase of the cell cycle.

Enzyme Numbers (IUBMB) for CDK11A Gene

Gene Ontology (GO) - Molecular Function for CDK11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity NAS 9750192
GO:0004674 protein serine/threonine kinase activity IDA 12501247
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IDA 12501247
genes like me logo Genes that share ontologies with CDK11A: view
genes like me logo Genes that share phenotypes with CDK11A: view

Animal Model Products

CRISPR Products

miRNA for CDK11A Gene

miRTarBase miRNAs that target CDK11A

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDK11A Gene

Localization for CDK11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK11A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK11A Gene COMPARTMENTS Subcellular localization image for CDK11A gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CDK11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CDK11A: view

Pathways for CDK11A Gene

genes like me logo Genes that share pathways with CDK11A: view

Gene Ontology (GO) - Biological Process for CDK11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEP 10882096
GO:0006355 regulation of transcription, DNA-templated NAS 9750192
GO:0006468 protein phosphorylation IDA 12501247
GO:0006915 apoptotic process NAS 9750192
GO:0007067 mitotic nuclear division NAS 1639388
genes like me logo Genes that share ontologies with CDK11A: view

Compounds for CDK11A Gene

(3) HMDB Compounds for CDK11A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with CDK11A: view

Transcripts for CDK11A Gene

mRNA/cDNA for CDK11A Gene

(18) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(23) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDK11A Gene

Cyclin-dependent kinase 11A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDK11A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CDK11A
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK11A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a ·
SP1: -
SP2:
SP3:
SP4: - - - - - - - - - - - - - - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14: -
SP15: - -

ExUns: 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b · 23c
SP1: - -
SP2: - -
SP3: - -
SP4: - - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8: -
SP9: - -
SP10: - -
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CDK11A Gene

GeneLoc Exon Structure for
CDK11A
ECgene alternative splicing isoforms for
CDK11A

Expression for CDK11A Gene

mRNA expression in normal human tissues for CDK11A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDK11A Gene

SOURCE GeneReport for Unigene cluster for CDK11A Gene Hs.651228

mRNA Expression by UniProt/SwissProt for CDK11A Gene

Q9UQ88-CD11A_HUMAN
Tissue specificity: Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
genes like me logo Genes that share expressions with CDK11A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDK11A Gene

Orthologs for CDK11A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK11A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK11B 35
  • 97.95 (n)
  • 97.83 (a)
cow
(Bos Taurus)
Mammalia CDC2L1 35
  • 87.43 (n)
  • 94.28 (a)
CDC2L1 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 90 (a)
OneToMany
CDK11B 35
  • 85.77 (n)
  • 94.1 (a)
mouse
(Mus musculus)
Mammalia Cdk11b 35
  • 84.27 (n)
  • 92.18 (a)
Cdk11b 36
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cdk11b 35
  • 85 (n)
  • 92.56 (a)
chicken
(Gallus gallus)
Aves CDC2L1 35
  • 76.77 (n)
  • 93.24 (a)
CDC2L1 36
  • 92 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk11b 35
  • 73.16 (n)
  • 89.33 (a)
zebrafish
(Danio rerio)
Actinopterygii cdk11b 35
  • 80.67 (n)
  • 87.7 (a)
cdk11b 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pitslre 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.2 36
  • 41 (a)
ManyToMany
ZC504.3 36
  • 36 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 36
  • 27 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07880 35
  • 53.04 (n)
  • 47.51 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppk23 35
  • 50.26 (n)
  • 47.63 (a)
Species with no ortholog for CDK11A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK11A Gene

ENSEMBL:
Gene Tree for CDK11A (if available)
TreeFam:
Gene Tree for CDK11A (if available)

Paralogs for CDK11A Gene

Paralogs for CDK11A Gene

genes like me logo Genes that share paralogs with CDK11A: view

Variants for CDK11A Gene

Sequence variations from dbSNP and Humsavar for CDK11A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs760925 -- 1,715,135(+) GCTTT(C/T)ACCCA intron-variant
rs760926 -- 1,715,218(+) GTCTC(C/T)CTACG intron-variant
rs760927 -- 1,715,350(+) TTTTG(C/T)TCATT intron-variant
rs760928 -- 1,715,860(+) ATATA(C/T)AGACT intron-variant
rs760929 -- 1,715,862(+) ATACA(A/G)ACTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDK11A Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv10n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
dgv9e1 CNV Complex 17122850
dgv43n71 CNV Loss 21882294
nsv871954 CNV Loss 21882294
nsv871540 CNV Gain 21882294
dgv45n71 CNV Loss 21882294
nsv870847 CNV Loss 21882294
dgv47n71 CNV Loss 21882294
nsv871583 CNV Loss 21882294
esv27786 CNV Gain 19812545
esv2748696 CNV Deletion 23290073
nsv871749 CNV Gain+Loss 21882294
nsv870598 CNV Gain 21882294
dgv2e199 CNV Deletion 23128226
dgv3n67 CNV Gain 20364138
dgv49n71 CNV Loss 21882294
dgv50n71 CNV Gain 21882294
nsv871030 CNV Gain 21882294
dgv51n71 CNV Loss 21882294
dgv10e1 CNV Complex 17122850
nsv482957 CNV Loss 15286789
dgv52n71 CNV Loss 21882294
dgv53n71 CNV Gain 21882294
nsv871560 CNV Loss 21882294
nsv442858 CNV CNV 18776908
nsv436343 CNV Deletion 17901297
nsv834091 CNV Loss 17160897
nsv482168 CNV Gain 20164927
nsv822475 CNV Gain 20364138
nsv822586 CNV Gain 20364138
nsv822697 CNV Loss 20364138
nsv871903 CNV Gain+Loss 21882294
nsv871121 CNV Gain 21882294
essv725 CNV CNV 17122850
nsv822809 CNV Loss 20364138
nsv509368 CNV Insertion 20534489
esv2748807 CNV Deletion 23290073
nsv436733 CNV Insertion 17901297
esv2748918 CNV Deletion 23290073
nsv159838 CNV Loss 16902084
esv988165 CNV Deletion 20482838
esv1455500 CNV Deletion 17803354
nsv160496 CNV Loss 16902084
dgv3e201 CNV Deletion 23290073
dgv4e201 CNV Deletion 23290073
esv2749585 CNV Deletion 23290073
nsv160062 CNV Loss 16902084
esv2749696 CNV Deletion 23290073
esv6106 CNV Loss 19470904
nsv160158 CNV Insertion 16902084
esv2668621 CNV Deletion 23128226

Relevant External Links for CDK11A Gene

HapMap Linkage Disequilibrium report
CDK11A
Human Gene Mutation Database (HGMD)
CDK11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK11A Gene

Disorders for CDK11A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CDK11A Gene including...

Search for CDK11A Gene in MalaCards »

Relevant External Links for CDK11A

Genetic Association Database (GAD)
CDK11A
Human Genome Epidemiology (HuGE) Navigator
CDK11A
genes like me logo Genes that share disorders with CDK11A: view

No data available for UniProtKB/Swiss-Prot for CDK11A Gene

Publications for CDK11A Gene

  1. Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2. (PMID: 9750192) Gururajan R. … Kidd V.J. (Genome Res. 1998) 2 3 4
  2. Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. (PMID: 10882096) Cornelis S. … Beyaert R. (Mol. Cell 2000) 3 4
  3. Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. (PMID: 7920654) Lahti J.M. … Kidd V.J. (Nat. Genet. 1994) 2 3
  4. Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms. (PMID: 8195233) Xiang J. … Kidd V.J. (J. Biol. Chem. 1994) 3 4
  5. CDK11 complexes promote pre-mRNA splicing. (PMID: 12501247) Hu D. … Kidd V.J. (J. Biol. Chem. 2003) 3 4

Products for CDK11A Gene

Sources for CDK11A Gene

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