Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK10 Gene

protein-coding   GIFtS: 61
GCID: GC16P089753

Cyclin-Dependent Kinase 10

(Previous name: cyclin-dependent kinase (CDC2-like) 10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cyclin-Dependent Kinase 101 2     PISSLRE2 5
Cyclin-Dependent Kinase (CDC2-Like) 101 2     CDC2-Related Protein Kinase2
Cell Division Protein Kinase 102 3     Cyclin-Dependent Kinase Related Protein2
Serine/Threonine-Protein Kinase PISSLRE2 3     Serine/Threonine Protein Kinase PISSLRE2
EC 2.7.11.223 8     EC 2.7.118

External Ids:    HGNC: 17701   Entrez Gene: 85582   Ensembl: ENSG000001853247   OMIM: 6034645   UniProtKB: Q151313   
ORGUL members:         
NONCODE14:n407987 n407986      

Export aliases for CDK10 gene to outside databases

Previous GC identifers: GC16P081075 GC16P090742 GC16P089455 GC16P089496 GC16P088280 GC16P075448


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDK10 Gene:
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK
subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are
known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular
proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, May 2009)

GeneCards Summary for CDK10 Gene: 
CDK10 (cyclin-dependent kinase 10) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CDK10 include seminoma, and biliary tract cancer. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is CDK20.

Gene Wiki entry for CDK10 (Cyclin-dependent kinase 10) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010542.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDK10 gene promoter:
         AML1a   Olf-1   CUTL1   ITF-2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK10 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

CDK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK10 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P089753:  view genomic region     (about GC identifiers)

Start:
89,747,145 bp from pter      End:
89,762,772 bp from pter
Size:
15,628 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CDK10

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDK10_HUMAN, Q15131 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 10  
Size: 360 amino acids; 41038 Da
Secondary accessions: A8MXU6 B7Z420 D3DX82 D3DX83 Q0VGZ7 Q15130 Q6PJC0
Alternative splicing: 4 isoforms:  Q15131-1   Q15131-2   Q15131-3   Q15131-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK10: NX_Q15131

Explore proteomics data for CDK10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15131

  • 4/9 DME Specific Peptides for CDK10 (Q15131) (see all 9)
     VVTLWYR  DFGLARA  IGEGTYG  YRAPELLL 

    CDK10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDK10 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001092003.2  NP_001153839.1  NP_443713.2  NP_443714.3  

    ENSEMBL proteins: 
     ENSP00000329957   ENSP00000338673   ENSP00000423370   ENSP00000424415   ENSP00000426102  
     ENSP00000421597   ENSP00000426264   ENSP00000455976   ENSP00000457055   ENSP00000456788  

    Human Recombinant Protein Products for CDK10: 
    EMD Millipore Purified and/or Recombinant CDK10 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CDK10
    OriGene Protein Over-expression Lysate for CDK10
    OriGene MassSpec for CDK10 
    OriGene Custom Protein Services for CDK10
    GenScript Custom Purified and Recombinant Proteins Services for CDK10
    Novus Biologicals CDK10 Protein
    Novus Biologicals CDK10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK10 


    CDK10 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CDK10
    OriGene Custom Antibody Services for CDK10
    GenScript Custom Superior Antibodies Services for CDK10
    Novus Biologicals CDK10 Antibodies
    Search for Antibodies for CDK10 at Abcam
    Cloud-Clone Corp. Antibodies for CDK10 
    ThermoFisher Antibodies for CDK10
    LSBio Antibodies in human, mouse, rat for CDK10 

    Assay Products for CDK10: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDK10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK10 
    Cloud-Clone Corp. CLIAs for CDK10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 10 
    CDK10 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q15131

    ProtoNet protein and cluster: Q15131

    UniProtKB/Swiss-Prot: CDK10_HUMAN, Q15131
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK10_HUMAN, Q15131
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for CDK10:
    cyclin dependent kinase (CDC2-like) related protein kinase,with several isoforms resulting from complex
    splicing,acting in G2 phase of the cell cycle,not deleted in sporadic breast carcinoma

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI18242510
         
    CDK10 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDK10:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased viability with 4OH t  Paclitaxel antagonistic effect 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK10 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDK10:
    hsa-mir-210 (MIRT003168), hsa-mir-197 (MIRT004208)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK10
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CDK10
    SwitchGear 3'UTR luciferase reporter plasmidCDK10 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDK10
    Sirion Biotech Customized adenovirus for overexpression of CDK10

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDK10 (see all 21)
    OriGene ORF clones in mouse, rat for CDK10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CDK10 (NM_052988)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK10
    Sirion Biotech Customized lentivirus for stable overexpression of CDK10 
                         Customized lentivirus expression plasmids for stable overexpression of CDK10 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDK10
    Search LifeMap BioReagents cell lines for CDK10
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDK10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell Cycle Control of Chromosomal Replication
    Cell Cycle Control of Chromosomal Replication
    2GADD45 Pathway
    GADD45 Pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDK10
        Cell Cycle Control of Chromosomal Replication
    GADD45 Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDK10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/8 Interacting proteins for CDK10 (Q151311, 3 ENSP000003386734) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS2P150361, 3, ENSP000003533444EBI-1646959,EBI-1646991 I2D: score=3 STRING: ENSP00000353344
    PIN1Q135261, 3, ENSP000002479704EBI-1646959,EBI-714158 I2D: score=1 STRING: ENSP00000247970
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    RAF1P040493, ENSP000002518494I2D: score=1 STRING: ENSP00000251849
    HSP90AB1P082381EBI-1646959,EBI-352572
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007089traversing start control point of mitotic cell cycle TAS8208557
    GO:0008285negative regulation of cell proliferation TAS8208557

    CDK10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for CDK10:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDK10

    2 HMDB Compounds for CDK10    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about CDK10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDK10 gene (5 alternative transcripts): 
    NM_001098533.2  NM_001160367.1  NM_052987.3  NM_052988.4  NM_003674.2  

    Unigene Cluster for CDK10:

    Cyclin-dependent kinase 10
    Hs.699177  [show with all ESTs]
    Unigene Representative Sequence: AK131531
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000331006 ENST00000353379(uc002foa.2 uc002fod.3 uc002foe.3 uc002fof.3 uc010cio.3 uc002fog.4 uc002foh.4 uc002foi.3)
    ENST00000508723 ENST00000505473 ENST00000511415 ENST00000502547 ENST00000512912
    ENST00000505733 ENST00000510811 ENST00000507205 ENST00000472018(uc010cip.2 uc010vpl.1)
    ENST00000564192(uc002fob.2) ENST00000378277 ENST00000514965 ENST00000503560
    ENST00000504473 ENST00000568456 ENST00000561477
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK10
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CDK10
    SwitchGear 3'UTR luciferase reporter plasmidCDK10 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDK10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK10
    Clone
    Products:
         
    OriGene clones in human, mouse for CDK10 (see all 21)
    OriGene ORF clones in mouse, rat for CDK10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CDK10 (NM_052988)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK10
    Sirion Biotech Customized lentivirus for stable overexpression of CDK10 
                         Customized lentivirus expression plasmids for stable overexpression of CDK10 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK10

    Additional mRNA sequence: 

    AK131531.1 AK290485.1 AK292351.1 AK295397.1 AK296631.1 AK298386.1 AK312016.1 BC017342.2 
    BC025301.1 L33264.1 NR_027702.1 NR_027703.1 

    24/29 DOTS entries (see all 29):

    DT.92413136  DT.100837924  DT.120667672  DT.97847207  DT.100816583  DT.97847205  DT.120667665  DT.86854973 
    DT.95252922  DT.100816578  DT.95252931  DT.100836930  DT.95306968  DT.100816587  DT.100816593  DT.101984825 
    DT.95252941  DT.99958417  DT.120667608  DT.120667648  DT.102830992  DT.120667647  DT.120667667  DT.91646980 

    24/255 AceView cDNA sequences (see all 255):

    BM790720 AK075036 AU100162 CB051082 AW137031 AA150212 AI963135 AU107435 
    AI653574 BX370771 BQ184950 BM773127 CR624710 CR602954 BM924066 BI823967 
    BQ214789 BC025301 BM142087 CK819887 BI826027 AI660494 BM452234 BM720563 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for CDK10 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ·
    SP1:                                -     -     -                 -                                   -           -                 -     -     -     -         
    SP2:                                      -     -     -     -     -                                   -           -                 -     -     -     -         
    SP3:                                -     -     -                 -                                   -           -                 -     -     -     -         
    SP4:                                      -     -                 -                                   -           -                 -     -     -     -         
    SP5:                                -     -     -                 -                                   -           -                 -     -     -     -         

    ExUns: 11c · 11d ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d · 15e
    SP1:        -     -     -                             -                           
    SP2:        -     -     -                                                         
    SP3:        -                                                                     
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for CDK10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGACCCAA
    CDK10 Expression
    About this image


    See CDK10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK10

    SOURCE GeneReport for Unigene cluster: Hs.699177
        SABiosciences Custom PCR Arrays for CDK10
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDK10
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK10
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK10 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk101 , 5 cyclin-dependent kinase 101, 5 87.04(n)1
    96.94(a)1
      8 (72.09 cM)5
    2348541  NM_194446.21  NP_919428.11 
     1232248415 
    chicken
    (Gallus gallus)
    Aves CDK101 cyclin-dependent kinase 10 79.57(n)
    84.96(a)
      415840  NM_001109939.1  NP_001103409.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK106
    Uncharacterized protein
    71(a)
    1 ↔ 1
    GL343487.1(618254-631732)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.127572 Xenopus laevis transcribed sequence with moderate similarity more 79.57(n)    BJ071284.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.168352 Transcribed sequence with moderate similarity to protein more 76.67(n)    BI983627.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cdc2rk1 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    cdc2-related-kinase1
    66(a)
    (best of 2)3
    64.92(n)1
    66.46(a)1
      46E13
    360511  NM_078950.31  NP_523674.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTK16
    Catalytic (alpha) subunit of C-terminal domain kin...
    24(a)
    1 → many
    XI(182958-184544)


    ENSEMBL Gene Tree for CDK10 (if available)
    TreeFam Gene Tree for CDK10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK10 gene
    CDK202  CDK11A2  CDK11B2  CDK72  
    18/130 SIMAP similar genes for CDK10 using alignment to 10 protein entries:     CDK10_HUMAN (see all proteins) (see all similar genes):
    EIF3G    pp12301    ADCK1    PPP5D1    ARIH1    NDC80
    NELFA    PFKFB3    ZNF66    C12orf76    IRF2    VPS33A
    FLJ00047    NXPE2    RRM2B    EEF1E1    HINFP    NLRC5

    CDK10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/394 SNPs in CDK10 are shown (see all 394)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467878151,2
    --75446390(+) GCTGCA/GACTAC 6 -- us2k10--------
    rs1891337071,2
    --89751154(+) ATCTCC/TTGACC 6 -- us2k10--------
    rs1924663261,2
    --89751167(+) GTGATC/TGACCC 6 -- us2k10--------
    rs1394702801,2
    --89751172(+) CGACCC/TGCCTC 6 -- us2k10--------
    rs4577081,2
    C,F,H--89751327(+) gggaaC/Gaggcc 6 -- us2k112Minor allele frequency- G:0.16NA WA CSA EA 373
    rs1169203001,2
    C,F--89751350(+) CATCAA/CCTGGC 6 -- us2k11Minor allele frequency- C:0.06EA 120
    rs620671121,2
    C,F--89751368(+) CTGGCC/TATAAA 6 -- us2k14Minor allele frequency- T:0.17NA WA EA 244
    rs1445491521,2
    --89751395(+) CTGTGA/GCATGC 6 -- us2k10--------
    rs1181617681,2
    F--89751433(+) AATGAG/AGGCAA 6 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1466339971,2
    --89751508(+) ATGAGC/TGATCT 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK10 (89747145 - 89762772 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for CDK10 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509639CNV Insertion20534489
    nsv907425CNV Loss21882294
    dgv3009n71CNV Loss21882294
    dgv3012n71CNV Loss21882294
    nsv833330CNV Loss17160897
    nsv907420CNV Loss21882294
    nsv907424CNV Loss21882294
    nsv907423CNV Loss21882294
    nsv516241CNV Loss19592680
    dgv3008n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CDK10
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603464    OMIM disorders: --

    6 diseases for CDK10:    About MalaCards
    seminoma    biliary tract cancer    ovarian cancer    melanoma
    breast cancer    hepatitis


    CDK10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDK10

    Export disorders for CDK10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK10 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with CDK10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PISSLRE, a human novel CDC2-related protein kinase. (PubMed id 8208557)1, 2, 3 Grana X.... Giordano A. (1994)
    2. Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. (PubMed id 8084611)1, 2, 3 Brambilla R. and Draetta G. (1994)
    3. Genome-wide association study identifies three new mel anoma susceptibility loci. (PubMed id 21983787)1, 4 Barrett J.H....Bishop D.T. (2011)
    4. A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. (PubMed id 18483556)1, 4 Han J....Hunter D.J. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer. (PubMed id 10036189)1, 2 Crawford J.... Savoia A. (1999)
    7. Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity. (PubMed id 11313931)1, 9 Kasten M. and Giordano A. (2001)
    8. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. (PubMed id 7882308)1, 9 Bullrich F....Croce C.M. (1995)
    9. Human CDK10 gene isoforms. (PubMed id 11006117)1, 9 Sergere J.C.... Leteurtre F. (2000)
    10. Effects of partner proteins on BCA2 RING ligase activi ty. (PubMed id 22315970)1 Bacopulos S....Seth A.K. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8558 HGNC: 1770 AceView: CDK10 Ensembl:ENSG00000185324 euGenes: HUgn8558
    ECgene: CDK10 H-InvDB: CDK10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDK10 gene:
    Search GeneIP for patents involving CDK10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore small molecules (inhibitor) for CDK10
     EMD Millipore Purified and/or Recombinant CDK10 Protein
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CDK10   OriGene RNAi products in human, mouse, rat for CDK10  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CDK10  
     OriGene MassSpec something-or-other for CDK10   OriGene clones in human, mouse for CDK10  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDK10   OriGene Purified Protein for CDK10  
     OriGene ORF clones in mouse, rat for CDK10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDK10   OriGene Custom Protein Services for CDK10  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDK10
     QIAGEN SeqTarget long-range PCR primers for resequencing CDK10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK10
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK10
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK10
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK10
     GenScript Custom Purified and Recombinant Proteins Services for CDK10 GenScript cDNA clones with any tag delivered in your preferred vector for CDK10
     GenScript Custom Assay Services for CDK10 GenScript Custom Superior Antibodies Services for CDK10
     GenScript Custom overexpressing Cell Line Services for CDK10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CDK10 promoter
     Search Chromatin IP Primers for CDK10
     RT2 qPCR Primer Assay in human, mouse, rat CDK10
     GNC Network for CDK10
     SABiosciences PCR Arrays including human, mouse, rat CDK10
     Search Tocris compounds for CDK10
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CDK10 antibodies
     CDK10 proteins
     CDK10 lysates
     Search for Antibodies for CDK10 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CDK10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CDK10
     Antibodies for CDK10
     ELISAs for CDK10
     CLIAs for CDK10
     Search LifeMap BioReagents cell lines for CDK10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK10
     SwitchGear 3'UTR luciferase reporter plasmids for CDK10
     SwitchGear Promoter luciferase reporter plasmids for CDK10
     ThermoFisher Antibodies for CDK10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK10
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CDK10
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDK10
    Customized:
     lentivirus for stable overexpression of CDK10
     lentivirus expression plasmids for stable overexpression of CDK10
     adenovirus for overexpression of CDK10
     LSBio Antibodies in human, mouse, rat for CDK10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDK10 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4