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CDK10 Gene

protein-coding   GIFtS: 57
GCID: GC16P089753

Cyclin-Dependent Kinase 10

(Previous name: cyclin-dependent kinase (CDC2-like) 10)
  See CDK10-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 101 2     PISSLRE2 5
Cyclin-Dependent Kinase (CDC2-Like) 101 2     CDC2-Related Protein Kinase2
Cell Division Protein Kinase 102 3     Cyclin-Dependent Kinase Related Protein2
Serine/Threonine-Protein Kinase PISSLRE2 3     Serine/Threonine Protein Kinase PISSLRE2
EC 2.7.11.223 8     EC 2.7.118

External Ids:    HGNC: 17701   Entrez Gene: 85582   Ensembl: ENSG000001853247   OMIM: 6034645   UniProtKB: Q151313   

Export aliases for CDK10 gene to outside databases

Previous GC identifers: GC16P081075 GC16P090742 GC16P089455 GC16P089496 GC16P088280 GC16P075448


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK10 Gene:
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK
subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are
known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular
proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, May 2009)

GeneCards Summary for CDK10 Gene:
CDK10 (cyclin-dependent kinase 10) is a protein-coding gene. Diseases associated with CDK10 include star syndrome. GO annotations related to this gene include cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is CDK11A.

Gene Wiki entry for CDK10 (Cyclin-dependent kinase 10) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CDK10 gene promoter:
         AML1a   Olf-1   CUTL1   ITF-2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK10 promoter sequence
   Search Chromatin IP Primers for CDK10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

CDK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK10 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P089753:  view genomic region     (about GC identifiers)

Start:
89,747,145 bp from pter      End:
89,762,772 bp from pter
Size:
15,628 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CDK10

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CDK10_HUMAN, Q15131 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 10  
Size: 360 amino acids; 41038 Da
Secondary accessions: A8MXU6 B7Z420 D3DX82 D3DX83 Q0VGZ7 Q15130 Q6PJC0
Alternative splicing: 4 isoforms:  Q15131-1   Q15131-2   Q15131-3   Q15131-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDK10: NX_Q15131

Explore proteomics data for CDK10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys76
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDK10 (Q15131) (see all 9)
     VVTLWYR  DFGLARA  IGEGTYG  YRAPELLL 


    See CDK10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001092003.2  NP_001153839.1  NP_443713.2  NP_443714.3  

    ENSEMBL proteins: 
     ENSP00000329957   ENSP00000338673   ENSP00000423370   ENSP00000424415   ENSP00000426102  
     ENSP00000421597   ENSP00000426264   ENSP00000455976   ENSP00000457055   ENSP00000456788  

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    Novus Biologicals CDK10 Protein
    Novus Biologicals CDK10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK10

     
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    antibodies-online proteins for CDK10 (2 products) 

     
    antibodies-online peptides for CDK10

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    antibodies-online antibodies for CDK10 (53 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 10
    CDK10 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q15131

    ProtoNet protein and cluster: Q15131

    UniProtKB/Swiss-Prot: CDK10_HUMAN, Q15131
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CDK10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK10_HUMAN, Q15131
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for CDK10:
    cyclin dependent kinase (CDC2-like) related protein kinase,with several isoforms resulting from complex
    splicing,acting in G2 phase of the cell cycle,not deleted in sporadic breast carcinoma

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI18242510
         
    Find genes that share ontologies with CDK10           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CDK10:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased viability with 4OH t  Paclitaxel antagonistic effect 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CDK10

    miRNA
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    miRTarBase miRNAs that target CDK10:
    hsa-mir-210-3p (MIRT003168), hsa-mir-197-3p (MIRT004208)

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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDK10

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    Sino Biological Human cDNA Clone for CDK10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK10
    Addgene plasmids for CDK10 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK10 About    
    See pathways by source

    SuperPathContained pathways About
    1GADD45 Pathway
    GADD45 Pathway
    2Cell Cycle Control of Chromosomal Replication
    Cell Cycle Control of Chromosomal Replication

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDK10
        Cell Cycle Control of Chromosomal Replication
    GADD45 Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDK10
    Interactions:

        GeneGlobe Interaction Network for CDK10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDK10 (Q151311, 3 ENSP000003386734) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS2P150361, 3, ENSP000003533444EBI-1646959,EBI-1646991 I2D: score=3 STRING: ENSP00000353344
    PIN1Q135261, 3, ENSP000002479704EBI-1646959,EBI-714158 I2D: score=1 STRING: ENSP00000247970
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    RAF1P040493, ENSP000002518494I2D: score=1 STRING: ENSP00000251849
    HSP90AB1P082381EBI-1646959,EBI-352572
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007089traversing start control point of mitotic cell cycle TAS8208557
    GO:0008285negative regulation of cell proliferation TAS8208557

    Find genes that share ontologies with CDK10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDK10

    2 HMDB Compounds for CDK10    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDK10 gene (5 alternative transcripts): 
    NM_001098533.2  NM_001160367.1  NM_052987.3  NM_052988.4  NM_003674.2  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000331006 ENST00000353379(uc002foa.2 uc002fod.3 uc002foe.3 uc002fof.3 uc010cio.3 uc002fog.4 uc002foh.4 uc002foi.3)
    ENST00000508723 ENST00000505473 ENST00000511415 ENST00000502547 ENST00000512912
    ENST00000505733 ENST00000510811 ENST00000507205 ENST00000472018(uc010cip.2 uc010vpl.1)
    ENST00000564192(uc002fob.2) ENST00000378277 ENST00000514965 ENST00000503560
    ENST00000504473 ENST00000568456 ENST00000561477
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDK10
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    GenScript: all cDNA clones in your preferred vector (see all 4): CDK10 (NM_052988)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK10
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK10
      QuantiTect SYBR Green Assays in human, mouse, rat CDK10
      QuantiFast Probe-based Assays in human, mouse, rat CDK10

    Selected AceView cDNA sequences (see all 255):

    CR615113 NM_052987 AU107435 BE857480 BF969521 BI771697 CR617735 L33264 
    AW137031 AA150212 BM773127 BM924066 BM720563 AI660494 BI823967 BX459786 
    NM_052988 BU742401 AU100162 AU107436 AW473588 BX370771 BC025301 AW089343 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK10 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ·
    SP1:                                -     -     -                 -                                   -           -                 -     -     -     -         
    SP2:                                      -     -     -     -     -                                   -           -                 -     -     -     -         
    SP3:                                -     -     -                 -                                   -           -                 -     -     -     -         
    SP4:                                      -     -                 -                                   -           -                 -     -     -     -         
    SP5:                                -     -     -                 -                                   -           -                 -     -     -     -         

    ExUns: 11c · 11d ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d · 15e
    SP1:        -     -     -                             -                           
    SP2:        -     -     -                                                         
    SP3:        -                                                                     
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for CDK10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDK10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGACCCAA
    CDK10 Expression
    About this image

    CDK10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK10 Protein Expression
        Custom PCR Arrays for CDK10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK10 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk101 , 5 cyclin-dependent kinase 101, 5 87.04(n)1
    96.94(a)1
      8 (72.09 cM)5
    2348541  NM_194446.21  NP_919428.11 
     1232248415 
    chicken
    (Gallus gallus)
    Aves CDK101 cyclin-dependent kinase 10 79.57(n)
    84.96(a)
      415840  NM_001109939.1  NP_001103409.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK106
    cyclin-dependent kinase 10
    73(a)
    1 ↔ 1
    GL343487.1(618254-631732)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.127572 Xenopus laevis transcribed sequence with moderate similarity more 79.57(n)    BJ071284.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.168352 Transcribed sequence with moderate similarity to protein more 76.67(n)    BI983627.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cdc2rk1 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    cdc2-related-kinase1
    66(a)
    (best of 2)3
    65.13(n)1
    66.46(a)1
      46E13
    360511  NM_078950.31  NP_523674.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTK16
    Catalytic (alpha) subunit of C-terminal domain kin...
    25(a)
    1 → many
    XI(182958-184544) YKL139W


    ENSEMBL Gene Tree for CDK10 (if available)
    TreeFam Gene Tree for CDK10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDK10 gene
    CDK11A2  CDK122  CDK132  CDK92  CDK11B2  
    Selected SIMAP similar genes for CDK10 using alignment to 10 protein entries:     CDK10_HUMAN (see all proteins) (see all similar genes):
    EIF3G    pp12301    ADCK1    PPP5D1    ARIH1    NDC80
    NELFA    PFKFB3    ZNF66    C12orf76    IRF2    VPS33A
    FLJ00047    RRM2B    EEF1E1    HINFP    NLRC5    SLC35E3

    Find genes that share paralogs with CDK10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDK10 (see all 394)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467878151,2
    --75446390(+) GCTGCA/GACTAC 6 -- us2k10--------
    rs1891337071,2
    --89751154(+) ATCTCC/TTGACC 6 -- us2k10--------
    rs1924663261,2
    --89751167(+) GTGATC/TGACCC 6 -- us2k10--------
    rs1394702801,2
    --89751172(+) CGACCC/TGCCTC 6 -- us2k10--------
    rs4577081,2
    C,F,H--89751327(+) gggaaC/Gaggcc 6 -- us2k112Minor allele frequency- G:0.16NA WA CSA EA 373
    rs1169203001,2
    C,F--89751350(+) CATCAA/CCTGGC 6 -- us2k11Minor allele frequency- C:0.06EA 120
    rs620671121,2
    C,F--89751368(+) CTGGCC/TATAAA 6 -- us2k14Minor allele frequency- T:0.17NA WA EA 244
    rs1445491521,2
    --89751395(+) CTGTGA/GCATGC 6 -- us2k10--------
    rs1181617681,2
    F--89751433(+) AATGAG/AGGCAA 6 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1466339971,2
    --89751508(+) ATGAGC/TGATCT 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDK10 (89747145 - 89762772 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CDK10 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509639CNV Insertion20534489
    nsv907425CNV Loss21882294
    dgv3009n71CNV Loss21882294
    dgv3012n71CNV Loss21882294
    nsv833330CNV Loss17160897
    nsv907420CNV Loss21882294
    nsv907424CNV Loss21882294
    nsv907423CNV Loss21882294
    nsv516241CNV Loss19592680
    dgv3008n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603464    OMIM disorders: --

    1 disease for CDK10:    
    About MalaCards
    star syndrome


    Find genes that share disorders with CDK10           About GenesLikeMe

    Genetic Association Database (GAD): CDK10

    Export disorders for CDK10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK10 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with CDK10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PISSLRE, a human novel CDC2-related protein kinase. (PubMed id 8208557)1, 2, 3 Grana X.... Giordano A. (Oncogene 1994)
    2. Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. (PubMed id 8084611)1, 2, 3 Brambilla R. and Draetta G. (Oncogene 1994)
    3. Genome-wide association study identifies three new melanoma susceptibility loci. (PubMed id 21983787)1, 4 Barrett J.H....Bishop D.T. (Nat. Genet. 2011)
    4. A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. (PubMed id 18483556)1, 4 Han J....Hunter D.J. (PLoS Genet. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer. (PubMed id 10036189)1, 2 Crawford J.... Savoia A. (Genomics 1999)
    7. Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity. (PubMed id 11313931)1, 9 Kasten M. and Giordano A. (Oncogene 2001)
    8. Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. (PubMed id 7882308)1, 9 Bullrich F....Croce C.M. (Cancer Res. 1995)
    9. Human CDK10 gene isoforms. (PubMed id 11006117)1, 9 Sergere J.C.... Leteurtre F. (Biochem. Biophys. Res. Commun. 2000)
    10. Promoter hypermethylation contributes to the frequent suppression of the CDK10 gene in human nasopharyngeal carcinomas. (PubMed id 23740091)1 You Y....Ran Y. (Cell Oncol (Dordr) 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8558 HGNC: 1770 AceView: CDK10 Ensembl:ENSG00000185324 euGenes: HUgn8558
    ECgene: CDK10 H-InvDB: CDK10

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDK10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDK10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDK10 gene:
    Search GeneIP for patents involving CDK10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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