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Aliases for CDK10 Gene

Aliases for CDK10 Gene

  • Cyclin Dependent Kinase 10 2 3 5
  • Cyclin-Dependent Kinase (CDC2-Like) 10 2 3
  • Cell Division Protein Kinase 10 3 4
  • EC 2.7.11.22 4 61
  • Cyclin-Dependent Kinase Related Protein 3
  • Serine/Threonine Protein Kinase PISSLRE 3
  • Serine/Threonine-Protein Kinase PISSLRE 4
  • CDC2-Related Protein Kinase 3
  • Cyclin-Dependent Kinase 10 3
  • EC 2.7.11 61
  • PISSLRE 3

External Ids for CDK10 Gene

Previous GeneCards Identifiers for CDK10 Gene

  • GC16P081075
  • GC16P090742
  • GC16P089455
  • GC16P089496
  • GC16P088280
  • GC16P089753
  • GC16P075448

Summaries for CDK10 Gene

Entrez Gene Summary for CDK10 Gene

  • The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

GeneCards Summary for CDK10 Gene

CDK10 (Cyclin Dependent Kinase 10) is a Protein Coding gene. Diseases associated with CDK10 include Star Syndrome and Tick Infestation. Among its related pathways are Cell Cycle Control of Chromosomal Replication and GADD45 Pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK11B.

UniProtKB/Swiss-Prot for CDK10 Gene

  • Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells).

Gene Wiki entry for CDK10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK10 Gene

Genomics for CDK10 Gene

Regulatory Elements for CDK10 Gene

Enhancers for CDK10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F089639 1.2 Ensembl ENCODE 49.3 -31.1 -31139 2.4 ATF1 PKNOX1 DMAP1 ZNF2 ZNF48 YY1 ZNF143 ZNF207 REST KAT8 CDK10 SPIRE2 GAS8-AS1 CHMP1A DPEP1 RPL13 PIR44959
GH16F089630 1.4 Ensembl ENCODE 32.8 -39.9 -39930 3.0 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 CDK10 CHMP1A TUBB3 RPL13 GALNS PIR44959 DPEP1
GH16F089825 1.3 FANTOM5 ENCODE 34 +156.1 156062 5.2 ATF1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 GLIS2 CDK10 FANCA SPIRE2 LOC105371419
GH16F089832 1.7 FANTOM5 Ensembl ENCODE 25.4 +164.1 164113 7.7 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 BRCA1 YY1 ZNF121 SLC30A9 CDK10 SPIRE2 TUBB3 VPS9D1 ZNF276 RPL13 FANCA ACSF3 MC1R LOC105371419
GH16F089815 1.1 ENCODE 36.7 +145.3 145274 4.3 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SPIRE2 CDK10 ENSG00000259006 ENSG00000261692 RNU6-430P ZNF778 GAS8 VPS9D1 LOC105371419
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDK10 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDK10 Gene

Chromosome:
16
Start:
89,672,247 bp from pter
End:
89,696,364 bp from pter
Size:
24,118 bases
Orientation:
Plus strand

Genomic View for CDK10 Gene

Genes around CDK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK10 Gene

Proteins for CDK10 Gene

  • Protein details for CDK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15131-CDK10_HUMAN
    Recommended name:
    Cyclin-dependent kinase 10
    Protein Accession:
    Q15131
    Secondary Accessions:
    • A8K370
    • A8K8I6
    • A8MXU6
    • B3KQJ3
    • B7Z420
    • D3DX82
    • D3DX83
    • Q0VGZ7
    • Q15130
    • Q6PJC0

    Protein attributes for CDK10 Gene

    Size:
    360 amino acids
    Molecular mass:
    41038 Da
    Quaternary structure:
    • Heterodimer with FAM58A/Cyclin-M, the interaction is required for kinase activity. Interacts with ETS2.

    Alternative splice isoforms for CDK10 Gene

neXtProt entry for CDK10 Gene

Selected DME Specific Peptides for CDK10 Gene

Q15131:
  • TDEIVALK
  • DFGLARA
  • TDEIVALKKVRMDKEKDG
  • QYSLRKQPYNNLKHKFPWLSEAGLRL
  • VVTLWYR
  • DLIVQLLGTPSENIWPGFS
  • LQVLRGLQYLHR
  • YRAPELLL
  • IGEGTYG

Post-translational modifications for CDK10 Gene

  • Ubiquitination at Lys 76
  • Modification sites at PhosphoSitePlus

Domains & Families for CDK10 Gene

Gene Families for CDK10 Gene

Protein Domains for CDK10 Gene

Graphical View of Domain Structure for InterPro Entry

Q15131

UniProtKB/Swiss-Prot:

CDK10_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with CDK10: view

Function for CDK10 Gene

Molecular function for CDK10 Gene

GENATLAS Biochemistry:
cyclin dependent kinase (CDC2-like) related protein kinase,with several isoforms resulting from complex splicing,acting in G2 phase of the cell cycle,not deleted in sporadic breast carcinoma
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells).

Enzyme Numbers (IUBMB) for CDK10 Gene

Gene Ontology (GO) - Molecular Function for CDK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA,TAS --
GO:0005515 protein binding IPI 18242510
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CDK10: view
genes like me logo Genes that share phenotypes with CDK10: view

Animal Model Products

miRNA for CDK10 Gene

miRTarBase miRNAs that target CDK10

Clone Products

  • Addgene plasmids for CDK10

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDK10 Gene

Localization for CDK10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDK10 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDK10 Gene

Pathways & Interactions for CDK10 Gene

genes like me logo Genes that share pathways with CDK10: view

Pathways by source for CDK10 Gene

1 GeneTex pathway for CDK10 Gene
1 Cell Signaling Technology pathway for CDK10 Gene

Gene Ontology (GO) - Biological Process for CDK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007089 traversing start control point of mitotic cell cycle TAS 8208557
GO:0008285 negative regulation of cell proliferation TAS 8208557
GO:0016310 phosphorylation IEA --
GO:0043410 positive regulation of MAPK cascade IEA --
genes like me logo Genes that share ontologies with CDK10: view

No data available for SIGNOR curated interactions for CDK10 Gene

Drugs & Compounds for CDK10 Gene

(2) Drugs for CDK10 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
alvocidib Pharma inhibitor Kinase Inhibitors 59

(1) Additional Compounds for CDK10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CDK10: view

Transcripts for CDK10 Gene

Unigene Clusters for CDK10 Gene

Cyclin-dependent kinase 10:
Representative Sequences:

Clone Products

  • Addgene plasmids for CDK10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDK10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - -
SP9: - - - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: - - - -
SP13: - - - - - -
SP14: - - -
SP15:
SP16:
SP17:
SP18:

ExUns: 11c · 11d ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - - - -
SP16:
SP17: - - -
SP18:

Relevant External Links for CDK10 Gene

GeneLoc Exon Structure for
CDK10
ECgene alternative splicing isoforms for
CDK10

Expression for CDK10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDK10 Gene

Protein differential expression in normal tissues from HIPED for CDK10 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDK10 Gene



Protein tissue co-expression partners for CDK10 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDK10 Gene:

CDK10

SOURCE GeneReport for Unigene cluster for CDK10 Gene:

Hs.699177
genes like me logo Genes that share expression patterns with CDK10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDK10 Gene

Orthologs for CDK10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK10 34 35
  • 92.46 (n)
oppossum
(Monodelphis domestica)
Mammalia CDK10 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK10 34 35
  • 89.85 (n)
dog
(Canis familiaris)
Mammalia CDK10 34 35
  • 88.15 (n)
rat
(Rattus norvegicus)
Mammalia Cdk10 34
  • 87.41 (n)
mouse
(Mus musculus)
Mammalia Cdk10 34 16 35
  • 87.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDK10 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDK10 34 35
  • 79.57 (n)
lizard
(Anolis carolinensis)
Reptilia CDK10 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk10 34
  • 75.15 (n)
Str.19111 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12757 34
zebrafish
(Danio rerio)
Actinopterygii cdk10 34 35
  • 71.55 (n)
Dr.16835 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10159 34
fruit fly
(Drosophila melanogaster)
Insecta cdc2rk 36 34 35
  • 65.13 (n)
CG6800 36
  • 35 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005851 34
  • 62.91 (n)
worm
(Caenorhabditis elegans)
Secernentea H01G02.2 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTK1 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 67 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13995 34
Species where no ortholog for CDK10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK10 Gene

ENSEMBL:
Gene Tree for CDK10 (if available)
TreeFam:
Gene Tree for CDK10 (if available)

Paralogs for CDK10 Gene

Paralogs for CDK10 Gene

genes like me logo Genes that share paralogs with CDK10: view

Variants for CDK10 Gene

Sequence variations from dbSNP and Humsavar for CDK10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1045814 -- 89,696,507(-) GGGCA(A/G)GGTGC downstream-variant-500B, utr-variant-3-prime
rs11076612 -- 89,689,941(+) GGCCT(C/T)CCAAA intron-variant
rs111245966 -- 89,695,475(+) ACAGG(A/G)GCATG intron-variant
rs111415935 -- 89,693,884(+) GACCC(-/CA)GTGTC intron-variant
rs111709034 -- 89,696,030(+) CCCCC(A/G)CTGTC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDK10 Gene

Variant ID Type Subtype PubMed ID
esv2762221 CNV gain+loss 21179565
esv3639592 CNV gain 21293372
nsv1057351 CNV loss 25217958
nsv428331 CNV gain+loss 18775914
nsv952079 CNV deletion 24416366
nsv833330 CNV loss 17160897
nsv573743 CNV gain 21841781
nsv573739 CNV gain 21841781
nsv516241 CNV loss 19592680
nsv509639 CNV insertion 20534489
nsv482951 CNV loss 15286789
nsv457623 CNV gain 19166990

Variation tolerance for CDK10 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDK10 Gene

Human Gene Mutation Database (HGMD)
CDK10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK10 Gene

Disorders for CDK10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDK10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
star syndrome
  • toe syndactyly, telecanthus, and anogenital and renal malformations
tick infestation
  • tick infestations
- elite association - COSMIC cancer census association via MalaCards
Search CDK10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDK10

Genetic Association Database (GAD)
CDK10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDK10
genes like me logo Genes that share disorders with CDK10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDK10 Gene

Publications for CDK10 Gene

  1. Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. (PMID: 8084611) Brambilla R. … Draetta G. (Oncogene 1994) 2 3 4 64
  2. PISSLRE, a human novel CDC2-related protein kinase. (PMID: 8208557) Grana X. … Giordano A. (Oncogene 1994) 2 3 4 64
  3. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. (PMID: 24218572) Guen V.J. … Colas P. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4 64
  4. Genome-wide association study identifies three new melanoma susceptibility loci. (PMID: 21983787) Barrett J.H. … Bishop D.T. (Nat. Genet. 2011) 3 46 64
  5. A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. (PMID: 18483556) Han J. … Hunter D.J. (PLoS Genet. 2008) 3 46 64

Products for CDK10 Gene

Sources for CDK10 Gene

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