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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDK1 Gene

protein-coding   GIFtS: 63
GCID: GC10P062539

cyclin-dependent kinase 1

(Previous names: cell division cycle 2, G1 to S and G2 to M )
(Previous symbol: CDC2)
 Explore 104 diseases affiliated with
CDK1 via
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Biological research products
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Aliases
for CDK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cyclin-Dependent Kinase 11 2     P34CDC22 3
CDC21 2 3 5     P34 Protein Kinase2 3
CDC28A1 2 3     Cell Cycle Controller CDC22
Cell Division Cycle 2, G1 To S And G2 To M1 2     CDKN13
Cell Division Control Protein 2 Homolog2 3     EC 2.7.11.223
Cell Division Protein Kinase 12 3     EC 2.7.11.233

External Ids:    HGNC: 17221   Entrez Gene: 9832   Ensembl: ENSG000001703127   OMIM: 1169405   UniProtKB: P064933   

Export aliases for CDK1 gene to outside databases

Previous GC identifers: GC10P062205 GC10P056527


Summaries
for CDK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDK1:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit
of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S
and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function
as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction
through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles
in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Mar 2009)

UniProtKB/Swiss-Prot: CDK1_HUMAN, P06493
Function: Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as
mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple
interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC,
AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII,
FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP,
GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1,
MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1,
NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A,
RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1,
VIM/vimentin, TK1, FOXO1, RUNX1/AML1 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized
eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated
dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least
centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are
condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated
phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope
and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and
genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through
WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In
proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3
proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of
postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1
phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring
complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation
regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The
phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8
phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation
occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes
H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during
peripheral nerve regeneration

Gene Wiki entry for CDK1 (Cyclin-dependent kinase 1)


Genomic Views
for CDK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDK1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.1   Ensembl cytogenetic band:  10q21.2   HGNC cytogenetic band: 10q21.2

CDK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P062539:  view genomic region     (about GC identifiers)

Start:
 62,538,089 bp from pter      End:
 62,554,610 bp from pter
Size:
 16,522 bases      Orientation:
 plus strand

Proteins
for CDK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDK1_HUMAN, P06493 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 1  
Size: 297 amino acids; 34095 Da
Subunit: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cyclins-B
(CCNB1, CCNB2 and CCNB3) to form a serine/threonine kinase holoenzyme complex also known as maturation promoting
factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Can also form CDK1-cylin-D and
CDK1-cyclin-E complexes that phosphorylate RB1 in vitro. Binds to RB1 and other transcription factors such as FOXO1
and RUNX2. Promotes G2-M transition when in complex with a cyclin-B. Interacts with DLGAP5. Binds to the CDK
inhibitors CDKN1A/p21 and CDKN1B/p27. Isoform 2 is unable to complex with cyclin-B1 and also fails to bind to
CDKN1A/p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during
interphase. Associates with cyclins-A and B1 during S-phase in regenerating hepatocytes. Interacts with FANCC.
Interacts with CEP63; this interaction recruits CDK1 to centrosomes
Subcellular location: Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic during
the interphase. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when
associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage
Miscellaneous: As a key regulator of the cell cycle, CDK1 is a potent therapeutic target for inhibitors in cancer
treatment (PubMed:21517772)
Sequence caution: Sequence=EAW54204.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for CDK1:
1LC9 (3D)    
Secondary accessions: A8K7C4 C9J497 O60764
Alternative splicing: 2 isoforms:  P06493-1   P06493-2   

Explore the universe of human proteins at neXtProt for CDK1: NX_P06493

Post-translational modifications:

  • Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1
    • prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and
    acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylation by PKMYT1 and WEE1 takes
    place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2. By the end of G2, PKMYT1 and WEE1
    are inactivated, but CDC25A and CDC25B are activated. Dephosphorylation by active CDC25A and CDC25B at Thr-14 and
    Tyr-15, leads to CDK1 activation at the G2-M transition. Phosphorylation at Tyr-15 by WEE2 during oogenesis is
    required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at
    dictyate prophase I, leading to prevent meiotic reentry. Phosphorylation by WEE2 is also required for metaphase II
    exit during egg activation to ensure exit from meiosis in oocytes and promote pronuclear formation. Phosphorylated at
    Tyr-4 by PKR/EIF2AK2 upon genotoxic stress. This phosphorylation triggers CDK1 polyubiquitination and subsequent
    proteolysis, thus leading to G2 arrest. In response to UV irradiation, phosphorylation at Tyr-15 by PRKCD activates
    the G2/M DNA damage checkpoint1
  • Polyubiquitinated upon genotoxic stress1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P06493

    • CDK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001163877.1  NP_001163878.1  NP_001777.1  NP_203698.1  

    ENSEMBL proteins: 
     ENSP00000430665   ENSP00000378699   ENSP00000397973   ENSP00000362915   ENSP00000325970  
    Reactome Protein details: P06493
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CDK1 Protein
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    Enzo Life Sciences proteins for CDK1
    OriGene Purified Protein: CDK1
    OriGene Protein Over-expression Lysate: CDK1
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    Novus Biologicals CDK1 Proteins
    Novus Biologicals CDK1 Lysates
    Sino Biological Recombinant Protein for CDK1
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDK1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion TAS19917720
    GO:0005815microtubule organizing center IEA--


    CDK1 for ontologies           About GeneDecksing



    CDK1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK1
    R&D Systems Antibodies for CDK1 (CDC2/CDK1)
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    OriGene Antibodies (see all 8): CDK1
    OriGene Custom Antibody Services for CDK1 
    GenScript Superior Antibodies for CDK1
    Novus Biologicals CDK1 Antibodies
    Abcam antibodies for CDK1 
    Uscn Antibodies for CDK1
    ThermoFisher Antibody for CDK1

    Assay Products for CDK1: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CDK1

    Protein Domains /
    Families
    for CDK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDK1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P06493

    ProtoNet protein and cluster: P06493

    UniProtKB/Swiss-Prot: CDK1_HUMAN, P06493
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CDK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDK1_HUMAN, P06493
    Function: Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as
    mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple
    interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC,
    AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII,
    FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP,
    GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1,
    MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1,
    NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A,
    RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1,
    VIM/vimentin, TK1, FOXO1, RUNX1/AML1 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized
    eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated
    dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least
    centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are
    condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated
    phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope
    and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and
    genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through
    WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In
    proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3
    proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of
    postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1
    phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring
    complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation
    regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The
    phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8
    phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation
    occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes
    H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during
    peripheral nerve regeneration
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
    Enzyme regulation: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161
    activates it. Activated through a multistep process; binding to cyclin-B is required for relocation of cyclin-kinase
    complexes to the nucleus, activated by CAK/CDK7-mediated phosphorylation on Thr-161, and CDC25-mediated
    dephosphorylation of inhibitory phosphorylation on Thr-14 and Tyr-15. Inhibited by flavopiridol and derivatives,
    pyrimidine derivatives, pyridine derivatives, purine derivatives, staurosporine, paullones, oxoindoles, indazole
    analogs, indolin-2-ones, pyrazolo[3,4-b]pyridines, imidazo[1,2-a]pyridine (AZ703), thiazolinone analogs(RO-3306),
    thiazol urea, macrocyclic quinoxalin-2-one, pyrrolo[2,3-a]carbazole, pyrazolo[1,5-a]-1,3,5-triazine,
    pyrazolo[1,5-a]pyrimidine (Dinaciclib, SCH 727965), 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
    (roscovitine), olomoucine, AG-024322, AT-7519, P276-00, R547/Ro-4584820 and SNS-032/BMS-387032. Repressed by the CDK
    inhibitors CDKN1A/p21 and CDKN1B/p27 during the G1 phase and by CDKN1A/p21 at the G1-S checkpoint upon DNA damage.
    Transient activation by rapid and transient dephosphorylation at Tyr-15 triggered by TGFB1
    Induction: Follows a cyclic expression; during interphase, accumulates gradually following G1, S to reach a critical
    threshold at the end of G2, which promotes self-activation and triggers onset of mitosis. Induced transiently by TGFB1
    at an early phase of TGFB1-mediated apoptosis, but later repressed. Triggered by CKS1B during mitotic entry in breast
    cancer cells. Down-regulated under genotoxic stresses triggered by PKR/EIF2AK2-mediated phosphorylation

    Enzyme Numbers (IUBMB): EC 2.7.11.231 EC 2.7.11.221

    miRNA
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    hsa-miR-513a-3p hsa-miR-330-3p hsa-miR-802 hsa-miR-378* hsa-miR-548c-3p
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity NAS9001210
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004693cyclin-dependent protein kinase activity TAS--
    GO:0005515protein binding IPI11687586
    GO:0005524ATP binding IEA--


    CDK1 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for CDK1:
     Cell cycle / mitosis defect  Decreased focal adhesion (FA)   Decreased substrate adherent c  G2 arrest 
     Increased G2M DNA content  Increased cell number in G2M,  

    Animal Models:
         Mouse knock-out Cdk1tm2.2Kald for CDK1
         9 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cdk1):
     cellular  embryogenesis  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system 
     mortality/aging  normal  reproductive system  tumorigenesis 

    CDK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/61 super-pathways (see all 61) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    2Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    3Ubiquitinated Orc1 is degraded by the proteasome
    		Degradation multiubiquitinated Cyclin A0.69
    		Regulation of APC/C activators between G1/S and early anaphase0.62
    		Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.69
    		Regulation of mitotic cell cycle0.58
    		APC/C:Cdc20 mediated degradation of mitotic proteins0.69
    		APC/C-mediated degradation of cell cycle proteins0.58
    		Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins0.68
    		Cell Cycle Checkpoints0.42
    4IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		Signaling by Insulin receptor0.74
    		IRS-related events triggered by IGF1R0.93
    5SHC-mediated signalling
    		SHC-mediated signalling1.00
    		SOS-mediated signalling0.71
    		SHC-related events0.88
    		GRB2 events in EGFR signaling0.71
    		SHC-related events triggered by IGF1R0.83
    		RAF/MAP kinase cascade0.67
    		SHC1 events in EGFR signaling0.76

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/12 EMD Millipore Pathways for CDK1 (see all 12)
        Cell cycle Role of APC in cell cycle regulation
    Apoptosis and survival Role of CDK5 in neuronal death and survival
    Meiosis
    Cell cycle Role of 14-3-3 proteins in cell cycle regulation
    Cell cycle Chromosome condensation in prometaphase


    1 Cell Signaling Technology (CST) Pathway for CDK1
        Cell Cycle / Checkpoint Control

    5/10 GeneGo (Thomson Reuters) Pathways for CDK1 (see all 10)
        Cell cycle Chromosome condensation in prometaphase
    Apoptosis and survival BAD phosphorylation
    Cell cycle Spindle assembly and chromosome separation
    Cell cycle Cell cycle (generic schema)
    Cell cycle Role of SCF complex in cell cycle regulation

    5/11 BioSystems Pathways for CDK1 (see all 11) 
        Hedgehog Signaling Pathway
    DNA damage response
    Cell cycle
    G1 to S cell cycle control
    TGF-beta Receptor Signaling Pathway

    5/118        Reactome Pathways for CDK1 (see all 118)
        Toll Like Receptor 2 (TLR2) Cascade
    SHC-related events
    Toll Like Receptor TLR6:TLR2 Cascade
    G0 and Early G1
    Recruitment of mitotic centrosome proteins and complexes

    1 PharmGKB Pathway for CDK1
        Busulfan Pathway, Pharmacodynamics

    5         Kegg Pathways  (Kegg details for CDK1):
        Cell cycle
    Oocyte meiosis
    p53 signaling pathway
    Gap junction
    Progesterone-mediated oocyte maturation


    CDK1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDK1

    5/750 Interacting proteins for CDK1 (P064931, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 750)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNB1P146351, 2, 3EBI-444308,EBI-495332 MINT-7945693 MINT-6549429 I2D: score=13 
    UBCP0CG482, 3MINT-7892156 MINT-7891847 MINT-7892113 MINT-7892143 MINT-7891862 MINT-7892126 MINT-7891945 I2D: score=2 
    EIF2AK2P195252, 3MINT-7892000 MINT-7892034 MINT-7891957 MINT-7892054 I2D: score=1 
    EEF2KO004182, 3MINT-6549314 MINT-6549429 MINT-6549466 I2D: score=1 
    SFNP319472, 3MINT-15829 MINT-15830 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/69 biological process terms (GO ID links to tree view) (see all 69):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S phase of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000165MAPK cascade TAS--


    CDK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDK1 for compounds           About GeneDecksing

    EMD Millipore small molecules for CDK1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CDK1

    Browse Tocris compounds for CDK1

    6 DrugBank Compounds for CDK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alsterpaullone-- --targetinhibitor11752352
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352
    Hymenialdisine-- --target--11752352
    Indirubin-3'-Monoxime-- --targetbinder11752352
    Olomoucine-- 101622-51-9targetbinder11752352
    SU9516-- --targetbinder11752352

    10/125 Novoseek chemical compound relationships for CDK1 gene (see all 125)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    roscovitine 84.4 49 15474478 (4), 14724573 (3), 9288122 (3), 18501396 (2) (see all 31)
    olomoucine 83.2 17 9288122 (3), 11896531 (2), 9046330 (1), 9300578 (1) (see all 12)
    nu2058 82.2 3 10956187 (1), 17599054 (1)
    butyrolactone i 76.9 12 10378783 (2), 10079191 (1), 9042196 (1), 8058318 (1) (see all 7)
    flavopiridol 69.9 14 15474478 (3), 11063609 (2), 9427698 (1), 9802881 (1) (see all 8)
    pstair 68.8 4 8407941 (2), 1833185 (1)
    alsterpaullone 66.9 2 15362121 (1), 14726692 (1)
    purvalanol a 66.2 1 10956385 (1)
    nocodazole 63.9 12 16669628 (2), 17160019 (1), 18418077 (1), 10194549 (1) (see all 9)
    tetra-o-methylnordihydroguaiaretic acid 62.4 2 17454637 (2)

    Search CenterWatch for drugs/clinical trials and news about CDK1 

    Transcripts
    for CDK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDK1 gene (5 alternative transcripts): 
    NM_001170406.1  NM_001170407.1  NM_001786.4  NM_033379.4  NM_001130829.1  

    Unigene Cluster for CDK1:

    Cyclin-dependent kinase 1
    Hs.732435  [show with all ESTs]
    Unigene Representative Sequence: CR933728
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519078 ENST00000475504(uc010qii.2 uc021prh.1) ENST00000395284(uc001jld.3 uc001jlg.3 uc001jle.3)
    ENST00000519760 ENST00000448257 ENST00000373809 ENST00000487784 ENST00000316629


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): CDK1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDK1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CDK1:
    hsa-miR-513a-3p hsa-miR-330-3p hsa-miR-802 hsa-miR-378* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CDK1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDK1 (see all 4)
    OriGene shRNA RFP: CDK1
    OriGene siRNA: CDK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDK1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDK1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDK1 (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): CDK1 (NM_001170406)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDK1
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK1

    Additional cDNA sequence: 

    AK291939.1 AK295741.1 BC014563.1 BT007004.1 CR933728.1 D88357.1 X05360.1 Y00272.1 

    7 DOTS entries:

    DT.455976  DT.99984670  DT.100019020  DT.87046806  DT.121298371  DT.121298359  DT.100781022 

    24/183 AceView cDNA sequences (see all 183):

    AA278384 AF055880 CA423827 BE252934 BC014563 BM982777 CR597955 BG684341 
    BX342068 BT007004 BU661041 AL520473 AA598974 AA278152 CR595214 BU625310 
    CR603310 AV716477 AA313715 BU538964 BU633268 AA460417 AI608775 BF968871 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDK1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c
    SP1:              -                             -     -                                                               
    SP2:                                            -     -                             -                                 
    SP3:                                            -     -                             -                                 
    SP4:        -     -                             -     -                                                               
    SP5:                                            -     -     -     -                 -                                 


    ECgene alternative splicing isoforms for CDK1

    Expression
    for CDK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)

    See CDK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDK1

    SOURCE GeneReport for Unigene cluster: Hs.732435

    UniProtKB/Swiss-Prot: CDK1_HUMAN, P06493
    Tissue specificity: Isoform 2 is found in breast cancer tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDK1 (see all 6): 
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Gap Junctions in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDK1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK1

    Orthologs
    for CDK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CDK1 gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDK11 cyclin-dependent kinase 1 80.52(n)
    93.58(a)    		   396252  NM_205314.1  NP_990645.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CDK16
    		 --
    		 86(a)
    		 1 ↔ 1
    		 GL343204.1(4018810-4036295)
    African clawed frog
    (Xenopus laevis)    		 Amphibia cdc2-prov2 Cell division control protein 2 homolog 1 78.15(n)    BC045078.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cdk11 cyclin-dependent kinase 1 73.65(n)
    84.88(a)    		   80973  NM_212564.2  NP_997729.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta cdc21 CDC2 kinase 63.08(n)
    73.96(a)    		   34411  NM_057449.3  NP_476797.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea cdk-11 Protein CDK-1 61.74(n)
    66.32(a)    		   176374  NM_001027576.2  NP_001022747.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CDKB2;26
    CDKB1;26
    (see all 4)    		 cyclin-dependent kinase B1-2
    (see all 4)    		 54(a)
    53(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 1(7292568-7294746)
    2(16152505-16154086)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 cyclin-dependent kinase B2-1, putative, expressed
    		 54(a)
    49(a)
    		 possible ortholog
    possible ortholog
    		 1(38980259-38983035)
    8(25417170-25419113)


    ENSEMBL Gene Tree for CDK1 (if available)
    TreeFam Gene Tree for CDK1 (if available) 

    Paralogs
    for CDK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDK1 gene
    CDK62  CDK182  CDK52  CDK152  CDK42  CDK32  CDK142  CDK162  
    CDK22  CDK172  
    18/106 SIMAP similar genes for CDK1 using alignment to 2 protein entries:     CDK1_HUMAN (see all proteins) (see all similar genes):
    CDC2    DKFZp686L20222    CDK3    PCTK3    CDK5    CDK17
    PCTK1    CDK16    CDK18    CDK2    CDK14    CDK7
    CDK6    STK3    CDK11B    CDK15    CDC2L1    CDC2L2

    CDK1 for paralogs           About GeneDecksing



    Genomic Variants
    for CDK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/339 NCBI SNPs in CDK1 are shown (see all 339)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs618532691,2
    		C,--56525798(+) NNNNTA/CAAGAA 4 -- us2k14Minor allele frequency- C:0.11NA WA EA 360
    rs32130081,2
    		C,H,--56526416(+) GTCTAG/ACTCTG 4 -- us2k15Minor allele frequency- A:0.00NS EA 582
    rs32130091,2
    		H--56526586(+) gtctcC/Tgcaaa 4 -- us2k15Minor allele frequency- T:0.00NS EA 582
    rs32130101,2
    		C,F,H,--56526668(+) AACTGC/TAGTAA 4 -- us2k1 tfbs316Minor allele frequency- T:0.03NS EA NA CSA WA 1720
    rs32130111,2
    		C,--56526826(+) gtggcG/Aagtgc 4 -- us2k11Minor allele frequency- A:0.01NS 166
    rs32130131,2
    		C,H,--56527115(+) GAGGCA/G/TGTCTT 4 -- us2k15NS EA 596
    rs32130141,2
    		H--56527140(+) TCCTTC/TTTAAG 4 -- us2k1 trp35Minor allele frequency- T:0.00NS EA 594
    rs32130151,2
    		H--56527206(+) TAACTA/GTACAC 4 -- us2k15Minor allele frequency- G:0.00NS EA 594
    rs1129320161,2
    		--56527400(+) ACTCTG/CCCGAC 4 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs32130171,2
    		C,F,H,--56527743(+) CGGCCG/TAGGGC 4 -- int14Minor allele frequency- T:0.01NS NA 348

    HapMap Linkage Disequilibrium report for CDK1 (62538089 - 62554610 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CDK1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDK1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK1

    Disorders / Diseases
    for CDK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDK1 for disorders           About GeneDecksing

    OMIM gene information: 116940    OMIM disorders: --

    20/104 diseases for CDK1 (see all 104):    About MalaCards
    diffuse large b-cell lymphoma    cervical intraepithelial neoplasia    spastic paraplegia    b-cell lymphomas
    hereditary spastic paraplegia    frontotemporal dementia    smooth muscle tumor    male germ cell tumor
    non-hodgkin lymphoma    bladder transitional cell carcinoma    germ cell tumor    transitional cell carcinoma
    squamous cell carcinoma    bloom syndrome    fanconi's anemia    myeloid leukemia
    paraplegia    cutaneous malignant melanoma    adenoid cystic carcinoma    oral squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for CDK1:
    Retinoblastoma

    10/61 Novoseek disease relationships for CDK1 gene (see all 61)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 73.2 34 16465393 (4), 1756735 (1), 8876167 (1), 14674679 (1) (see all 30)
    cancer 57.1 42 8318919 (3), 15645429 (2), 16687918 (2), 17481885 (2) (see all 29)
    tumors 52.2 80 17434927 (3), 18069625 (3), 14696091 (2), 15958646 (2) (see all 54)
    colon cancer 43.5 4 10216486 (2), 15001986 (1), 16024531 (1)
    myeloid leukemia 38.8 2 18505930 (1), 17636382 (1)
    prostate cancer 36.4 18 17070313 (3), 17043241 (2), 15961392 (1), 14652289 (1) (see all 10)
    cervical carcinoma 36.3 1 9201712 (1)
    breast cancer 33.5 23 19239702 (3), 9515786 (2), 11720835 (2), 20010939 (2) (see all 16)
    colon carcinoma 33.5 1 19223178 (1)
    promyelocytic leukemia 32.1 2 16619512 (1), 8936337 (1)

    Human Genome Epidemiology (HuGE) Navigator: CDK1 (11 documents)

    Export disorders for CDK1 gene to outside databases

    Publications
    for CDK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDK1 gene, integrated from 9 sources (see all 1483):
    (articles sorted by number of sources associating them with CDK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. (PubMed id 3553962)1, 2, 3 Lee M.G. and Nurse P. (1987)
    2. New Cdc2 Tyr 4 phosphorylation by dsRNA-activated pro tein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stre sses. (PubMed id 20395957)1, 2, 9 Yoon C.H....Bae Y.S. (2010)
    3. Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. (PubMed id 19509060)1, 2, 9 Zhang X....Zhang C. (2009)
    4. The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2. (PubMed id 9242535)1, 2, 9 Kupfer G.M....D'Andrea A.D. (1997)
    5. Cdc25 phosphatases are required for timely assembly o f CDK1-cyclin B at the G2/M transition. (PubMed id 20360007)1, 2, 9 Timofeev O....Hoffmann I. (2010)
    6. Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons. (PubMed id 18356527)1, 2, 9 Yuan Z....Bonni A. (2008)
    7. Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. (PubMed id 16407259)1, 2, 9 Qiao M....Passaniti A. (2006)
    8. Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. (PubMed id 16371510)1, 2, 9 Fourest-Lieuvin A....Job D. (2006)
    9. T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21. (PubMed id 9515786)1, 2, 9 Ohta T....Xiong Y. (1998)
    10. Cep63 recruits Cdk1 to the centrosome: implications f or regulation of mitotic entry, centrosome amplification, and genome maintenanc e. (PubMed id 21406398)1, 2 LAPffler H....KrAomer A. (2011)

    External Searches for CDK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 983 HGNC: 1722 AceView: CDC2 Ensembl:ENSG00000170312 euGenes: HUgn983
    ECgene: CDK1 Kegg: 983 H-InvDB: CDK1

    Other Databases showing CDK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDK1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc2/

    Intellectual Property
    for CDK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDK1 gene:
    Search GeneIP for patents involving CDK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CDK1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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     Browse Kits and Assays available from EMD Millipore
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