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CDK1 Gene

protein-coding   GIFtS: 60
GCID: GC10P062539

Cyclin-Dependent Kinase 1

(Previous names: cell division cycle 2, G1 to S and G2 to M)
(Previous symbol: CDC2)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cyclin-Dependent Kinase 11 2     P34CDC22 3
CDC21 2 3 5     P34 Protein Kinase2 3
Cell Division Cycle 2, G1 To S And G2 To M1 2     Cell Cycle Controller CDC22
Cell Division Control Protein 2 Homolog2 3     CDKN13
Cell Division Protein Kinase 12 3     EC 2.7.11.223
CDC28A2 3     EC 2.7.11.233

External Ids:    HGNC: 17221   Entrez Gene: 9832   Ensembl: ENSG000001703127   OMIM: 1169405   UniProtKB: P064933   

Export aliases for CDK1 gene to outside databases

Previous GC identifers: GC10P062205 GC10P056527


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDK1 Gene:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic
subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is
essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with
this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin
accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein
also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Mar 2009)

GeneCards Summary for CDK1 Gene:
CDK1 (cyclin-dependent kinase 1) is a protein-coding gene. Diseases associated with CDK1 include thyroid lymphoma, and myxofibrosarcoma. GO annotations related to this gene include RNA polymerase II carboxy-terminal domain kinase activity and protein kinase activity. An important paralog of this gene is CDK3.

UniProtKB/Swiss-Prot: CDK1_HUMAN, P06493
Function: Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well
as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with
multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates
PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A,
CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR,
FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB,
LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex,
PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB,
PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI,
BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1 and RUNX2.
CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of
embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin
complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics,
nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the
metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister
chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated
by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at
the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent
signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating
cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and
thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of
postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1
phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring
complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation
regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis.
The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast,
CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This
phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2
phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes
Schwann cell migration during peripheral nerve regeneration

summary for CDK1 Gene:
Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through
the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk
genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following
extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D
and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces
transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E
complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M
phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation
of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases,
including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by
molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks
is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability.
Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to
Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential
targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic
strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK1 (Cyclin-dependent kinase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CDK1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDK1 promoter sequence
   Search Chromatin IP Primers for CDK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.1   Ensembl cytogenetic band:  10q21.2   HGNC cytogenetic band: 10q21.2

CDK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDK1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P062539:  view genomic region     (about GC identifiers)

Start:
62,538,089 bp from pter      End:
62,554,610 bp from pter
Size:
16,522 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CDK1_HUMAN, P06493 (See protein sequence)
Recommended Name: Cyclin-dependent kinase 1  
Size: 297 amino acids; 34095 Da
Subunit: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with
cyclins-B (CCNB1, CCNB2 and CCNB3) to form a serine/threonine kinase holoenzyme complex also known as maturation
promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Can also form
CDK1-cylin-D and CDK1-cyclin-E complexes that phosphorylate RB1 in vitro. Binds to RB1 and other transcription
factors such as FOXO1 and RUNX2. Promotes G2-M transition when in complex with a cyclin-B. Interacts with DLGAP5.
Binds to the CDK inhibitors CDKN1A/p21 and CDKN1B/p27. Isoform 2 is unable to complex with cyclin-B1 and also
fails to bind to CDKN1A/p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an
endocytotic complex during interphase. Associates with cyclins-A and B1 during S-phase in regenerating
hepatocytes. Interacts with FANCC. Interacts with CEP63; this interaction recruits CDK1 to centrosomes
Miscellaneous: As a key regulator of the cell cycle, CDK1 is a potent therapeutic target for inhibitors in cancer
treatment (PubMed:21517772)
Sequence caution: Sequence=EAW54204.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for CDK1:
1LC9 (3D)    
Secondary accessions: A8K7C4 C9J497 O60764
Alternative splicing: 2 isoforms:  P06493-1   P06493-2   

Explore the universe of human proteins at neXtProt for CDK1: NX_P06493

Explore proteomics data for CDK1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1
    prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity
    and acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylation by PKMYT1 and WEE1
    takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2. By the end of G2, PKMYT1
    and WEE1 are inactivated, but CDC25A and CDC25B are activated. Dephosphorylation by active CDC25A and CDC25B at
    Thr-14 and Tyr-15, leads to CDK1 activation at the G2-M transition. Phosphorylation at Tyr-15 by WEE2 during
    oogenesis is required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period
    of quiescence at dictyate prophase I, leading to prevent meiotic reentry. Phosphorylation by WEE2 is also
    required for metaphase II exit during egg activation to ensure exit from meiosis in oocytes and promote
    pronuclear formation. Phosphorylated at Tyr-4 by PKR/EIF2AK2 upon genotoxic stress. This phosphorylation triggers
    CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest. In response to UV irradiation,
    phosphorylation at Tyr-15 by PRKCD activates the G2/M DNA damage checkpoint1
  • Polyubiquitinated upon genotoxic stress1
  • Ubiquitination2 at Lys9, Lys20, Lys24, Lys33, Lys34, Lys89, Lys130, Lys139, Lys143, Lys201,
                                 Lys238, Lys245, Lys254, Lys266, Lys274, Lys279, Lys295
  • Modification sites at PhosphoSitePlus

  • See CDK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001163877.1  NP_001163878.1  NP_001777.1  NP_203698.1  

    ENSEMBL proteins: 
     ENSP00000430665   ENSP00000378699   ENSP00000397973   ENSP00000362915   ENSP00000325970  
    Reactome Protein details: P06493

    CDK1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CDK1 Protein
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    OriGene Protein Over-expression Lysate for CDK1
    OriGene MassSpec for CDK1
    OriGene Custom Protein Services for CDK1
    GenScript Custom Purified and Recombinant Proteins Services for CDK1
    Novus Biologicals CDK1 Proteins
    Novus Biologicals CDK1 Lysates
    Sino Biological Recombinant Protein for CDK1
    Sino Biological Cell Lysate for CDK1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDK1

    CDK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDK1
    R&D Systems Antibodies for CDK1 (CDC2/CDK1)
    Cell Signaling Technology (CST) Antibodies for CDK1 
    OriGene Antibodies for CDK1
    OriGene Custom Antibody Services for CDK1
    Novus Biologicals CDK1 Antibodies
    Search for Antibodies for CDK1 at Abcam
    Cloud-Clone Corp. Antibodies for CDK1
    ThermoFisher Antibody for CDK1
    LSBio Antibodies in human, mouse, rat for CDK1

    CDK1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of CDK1
    OriGene Custom Assay Services for CDK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDK1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for CDK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDK1
    Cloud-Clone Corp. CLIAs for CDK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CDK: Cyclin-dependent kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: cyclin-dependent kinase 1
    CDK1 subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P06493

    ProtoNet protein and cluster: P06493

    UniProtKB/Swiss-Prot: CDK1_HUMAN, P06493
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    CDK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDK1_HUMAN, P06493
    Function: Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well
    as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with
    multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates
    PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A,
    CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR,
    FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB,
    LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex,
    PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB,
    PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI,
    BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1 and RUNX2.
    CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of
    embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin
    complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics,
    nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the
    metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister
    chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated
    by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at
    the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent
    signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating
    cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and
    thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of
    postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1
    phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring
    complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation
    regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis.
    The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast,
    CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This
    phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2
    phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes
    Schwann cell migration during peripheral nerve regeneration
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
    Enzyme regulation: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161
    activates it. Activated through a multistep process; binding to cyclin-B is required for relocation of
    cyclin-kinase complexes to the nucleus, activated by CAK/CDK7-mediated phosphorylation on Thr-161, and
    CDC25-mediated dephosphorylation of inhibitory phosphorylation on Thr-14 and Tyr-15. Inhibited by flavopiridol
    and derivatives, pyrimidine derivatives, pyridine derivatives, purine derivatives, staurosporine, paullones,
    oxoindoles, indazole analogs, indolin-2-ones, pyrazolo[3,4-b]pyridines, imidazo[1,2-a]pyridine (AZ703),
    thiazolinone analogs(RO-3306), thiazol urea, macrocyclic quinoxalin-2-one, pyrrolo[2,3-a]carbazole,
    pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine (Dinaciclib, SCH 727965),
    2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), olomoucine, AG-024322, AT-7519,
    P276-00, R547/Ro-4584820 and SNS-032/BMS-387032. Repressed by the CDK inhibitors CDKN1A/p21 and CDKN1B/p27 during
    the G1 phase and by CDKN1A/p21 at the G1-S checkpoint upon DNA damage. Transient activation by rapid and
    transient dephosphorylation at Tyr-15 triggered by TGFB1
    Induction: Follows a cyclic expression; during interphase, accumulates gradually following G1, S to reach a
    critical threshold at the end of G2, which promotes self-activation and triggers onset of mitosis. Induced
    transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis, but later repressed. Triggered by CKS1B
    during mitotic entry in breast cancer cells. Down-regulated under genotoxic stresses triggered by
    PKR/EIF2AK2-mediated phosphorylation

         Enzyme Numbers (IUBMB): EC 2.7.11.231 EC 2.7.11.221

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity NAS9001210
    GO:0004674protein serine/threonine kinase activity IDA19879842
    GO:0004693cyclin-dependent protein serine/threonine kinase activity TAS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10373560
         
    CDK1 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for CDK1:
     Cell cycle / mitosis defect  Decreased focal adhesion (FA)   Decreased substrate adherent c  G2 arrest 
     Increased G2M DNA content  Increased cell number in G2M,  

         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cdk1):
     cellular  embryogenesis  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system 
     mortality/aging  normal  reproductive system  tumorigenesis 

    CDK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdk1tm2.2Kald for CDK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDK1

    miRNA
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    miRTarBase miRNAs that target CDK1:
    hsa-mir-92a-3p (MIRT049057), hsa-mir-24-3p (MIRT030503), hsa-mir-193b-3p (MIRT016442), hsa-mir-663a (MIRT016140), hsa-mir-31-5p (MIRT007328), hsa-mir-590-3p (MIRT016189)

    Block miRNA regulation of human, mouse, rat CDK1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CDK1:
    hsa-miR-513a-3p hsa-miR-330-3p hsa-miR-802 hsa-miR-378* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidCDK1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): CDK1 (NM_001170406)
    Sino Biological Human cDNA Clone for CDK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK1

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDK1_HUMAN, P06493: Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome. Note=Cytoplasmic during the interphase. Reversibly translocated from cytoplasm to nucleus when
    phosphorylated before G2-M transition when associated with cyclin- B1. Accumulates in mitochondria in G2-arrested
    cells upon DNA- damage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    mitochondrion5
    nucleus5
    cytosol4
    peroxisome2
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion TAS19917720
    GO:0005815microtubule organizing center IEA--

    CDK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDK1 About   (see all 59)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1E2F mediated regulation of DNA replication
    Mitotic G1-G1/S phases0.81
    E2F mediated regulation of DNA replication0.30
    G1/S Transition0.81
    E2F-enabled inhibition of pre-replication complex formation0.00
    G1 to S cell cycle control0.35
    G1/S-Specific Transcription0.00
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    4PLK1 signaling events
    PLK1 signaling events
    Phosphorylation of Emi10.00
    5Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDK1 (see all 14)
        14-3-3 and Cell Cycle Regulation
    Cell Cycle Control by BTG Proteins
    Molecular Mechanisms of Cancer
    Calpain Protease Regulates Cellular Mechanics
    DNA Damage Induced 14-3-3Sigma Signaling

    1 Cell Signaling Technology (CST) Pathway for CDK1
        Cell Cycle / Checkpoint Control

    Selected GeneGo (Thomson Reuters) Pathways for CDK1 (see all 10)
        Cell cycle Chromosome condensation in prometaphase
    Apoptosis and survival BAD phosphorylation
    Cell cycle Spindle assembly and chromosome separation
    Cell cycle Cell cycle (generic schema)
    Cell cycle Role of SCF complex in cell cycle regulation

    Selected BioSystems Pathways for CDK1 (see all 15)
        Cell cycle
    DNA damage response
    G1 to S cell cycle control
    Hedgehog Signaling Pathway
    Spinal Cord Injury


    Selected Reactome Pathways for CDK1 (see all 27)
        Resolution of Sister Chromatid Cohesion
    G0 and Early G1
    E2F-enabled inhibition of pre-replication complex formation
    Recruitment of mitotic centrosome proteins and complexes
    Recruitment of NuMA to mitotic centrosomes

    1 PharmGKB Pathway for CDK1
        Busulfan Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for CDK1) (see all 8):
        Cell cycle
    Oocyte meiosis
    p53 signaling pathway
    Gap junction
    Progesterone-mediated oocyte maturation


    CDK1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK1 (see all 6): 
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CDK1

    Selected Interacting proteins for CDK1 (P064931, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 790)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG481, 2, 3EBI-444308,EBI-3390054 MINT-7892156 MINT-7891847 MINT-7892113 MINT-7892143 MINT-7891862 MINT-7892126 MINT-7891945 I2D: score=2 
    EIF2AK2P195251, 2, 3EBI-444308,EBI-640775 MINT-7892000 MINT-7892034 MINT-7891957 MINT-7892054 I2D: score=1 
    CCNB1P146351, 2, 3EBI-444308,EBI-495332 MINT-7945693 MINT-6549429 I2D: score=13 
    EEF2KO004182, 3MINT-6549314 MINT-6549429 MINT-6549466 I2D: score=1 
    SFNP319472, 3MINT-15829 MINT-15830 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 72):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000165MAPK cascade TAS--
    GO:0000186activation of MAPKK activity TAS--

    CDK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CDK1
    Selected ApexBio Compounds for CDK1 (see all 20)     About this table
    CompoundAction CAS #
    AT7519novel small molecule effective as a multi-cyclin-dependent kinase inhibitor[844442-38-2]
    AZD-5438Potent CDK1/2/9 inhibitor[602306-29-6]
    BMS265246potent and selective Cdk1/Cdk2 inhibitor[582315-72-8]
    BS-181 HClsmall molecule inhibitor which is highly selective for Cdk7 activity[1397219-81-6]
    Deferasiroxrationally-designed oral iron chelator[201530-41-8]
    Dinaciclib (SCH727965)CDK inhibitor[779353-01-4]
    Flavopiridol hydrochloridepan-cdk inhibitor[131740-09-5]
    LEE011orally available CDK inhibitor[1211441-98-3]
    LY2835219orally available CDK inhibitor, targets the CDK4 and CDK6[1231930-82-7]
    Nu 6027potent inhibitor of cellular ATR activity[220036-08-8]

    Compounds for CDK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SU 9516Potent cdk2 inhibitor[377090-84-1]
    Purvalanol ACyclin-dependent kinase inhibitor[212844-53-6]
    Ro 3306Cyclin-dependent kinase (cdk) 1 inhibitor[872573-93-8]
    Purvalanol BCyclin-dependent kinase inhibitor[212844-54-7]
    KenpaullonePotent cyclin-dependent kinase inhibitor. Also inhibits GSK-3[142273-20-9]

    6 DrugBank Compounds for CDK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alsterpaullone-- --targetinhibitor11752352
    FlavopiridolAlvocidib (see all 5)131740-09-5target--11752352
    Hymenialdisine-- --target--11752352
    Indirubin-3'-Monoxime-- --targetbinder11752352
    Olomoucine-- 101622-51-9targetbinder11752352
    SU9516-- --targetbinder11752352

    Selected Novoseek inferred chemical compound relationships for CDK1 gene (see all 125)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    roscovitine 84.4 49 15474478 (4), 14724573 (3), 9288122 (3), 18501396 (2) (see all 31)
    olomoucine 83.2 17 9288122 (3), 11896531 (2), 9046330 (1), 9300578 (1) (see all 12)
    nu2058 82.2 3 10956187 (1), 17599054 (1)
    butyrolactone i 76.9 12 10378783 (2), 10079191 (1), 9042196 (1), 8058318 (1) (see all 7)
    flavopiridol 69.9 14 15474478 (3), 11063609 (2), 9427698 (1), 9802881 (1) (see all 8)
    pstair 68.8 4 8407941 (2), 1833185 (1)
    alsterpaullone 66.9 2 15362121 (1), 14726692 (1)
    purvalanol a 66.2 1 10956385 (1)
    nocodazole 63.9 12 16669628 (2), 17160019 (1), 18418077 (1), 10194549 (1) (see all 9)
    tetra-o-methylnordihydroguaiaretic acid 62.4 2 17454637 (2)



    CDK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for CDK1 gene (5 alternative transcripts): 
    NM_001170406.1  NM_001170407.1  NM_001786.4  NM_033379.4  NM_001130829.1  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519078 ENST00000475504(uc010qii.2 uc021prh.1) ENST00000395284(uc001jld.3 uc001jlg.3 uc001jle.3)
    ENST00000519760 ENST00000448257 ENST00000373809 ENST00000487784 ENST00000316629

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDK1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CDK1:
    hsa-miR-513a-3p hsa-miR-330-3p hsa-miR-802 hsa-miR-378* hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidCDK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDK1
    Predesigned siRNA for gene silencing in human, mouse, rat CDK1
    Clone
    Products:
         
    OriGene clones in human, mouse for CDK1 (see all 23)
    OriGene ORF clones in mouse, rat for CDK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CDK1 (NM_001170406)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDK1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CDK1
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK1
      QuantiTect SYBR Green Assays in human, mouse, rat CDK1
      QuantiFast Probe-based Assays in human, mouse, rat CDK1

    Selected AceView cDNA sequences (see all 183):

    AL520473 AA598974 AI608775 BT007004 AU280243 AA460417 CR603310 BE252934 
    CR597955 BU661041 BU633268 AF055880 AA278384 CA423827 AV716477 BG684341 
    BF968871 AA278152 BU625310 BC014563 BU538964 BM982777 BX342068 AA313715 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDK1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c
    SP1:              -                             -     -                                                               
    SP2:                                            -     -                             -                                 
    SP3:                                            -     -                             -                                 
    SP4:        -     -                             -     -                                                               
    SP5:                                            -     -     -     -                 -                                 


    ECgene alternative splicing isoforms for CDK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDK1 Expression
    About this image


    CDK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Thymus
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
    CDK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDK1 Protein Expression

    UniProtKB/Swiss-Prot: CDK1_HUMAN, P06493
    Tissue specificity: Isoform 2 is found in breast cancer tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDK1 (see all 6): 
              Cancer Drug Targets in human mouse rat
              Cell Cycle in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Alzheimer's Disease in human mouse rat
              Gap Junctions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDK1
    OriGene qSTAR qPCR primer pairs in human, mouse for CDK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDK1
    QuantiTect SYBR Green Assays in human, mouse, rat CDK1
    QuantiFast Probe-based Assays in human, mouse, rat CDK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDK1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdk11 , 5 cyclin-dependent kinase 11, 5 86.08(n)1
    96.97(a)1
      10 (36.07 cM)5
    125341  NM_007659.31  NP_031685.21 
     693366355 
    chicken
    (Gallus gallus)
    Aves CDK11 cyclin-dependent kinase 1 80.36(n)
    93.27(a)
      396252  NM_205314.1  NP_990645.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDK16
    cyclin-dependent kinase 1
    84(a)
    1 ↔ 1
    GL343204.1(4017940-4041020)
    African clawed frog
    (Xenopus laevis)
    Amphibia cdc2-prov2 Cell division control protein 2 homolog 1 78.15(n)    BC045078.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdk11 cyclin-dependent kinase 1 73.65(n)
    84.88(a)
      80973  NM_212564.2  NP_997729.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cdc21 cdc2 63.08(n)
    73.96(a)
      34411  NM_057449.4  NP_476797.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cdk-11 cdk-1 61.64(n)
    66.1(a)
      176374  NM_001027576.3  NP_001022747.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC286
    Catalytic subunit of the main cell cycle cyclin-de...
    59(a)
    1 → many
    II(560078-560974) YBR160W


    ENSEMBL Gene Tree for CDK1 (if available)
    TreeFam Gene Tree for CDK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CDK1 gene
    CDK32  CDK62  CDK22  CDK42  
    Selected SIMAP similar genes for CDK1 using alignment to 2 protein entries:     CDK1_HUMAN (see all proteins) (see all similar genes):
    CDC2    DKFZp686L20222    CDK3    PCTK3    CDK5    CDK17
    PCTK1    CDK16    CDK18    PHKG2    CDK2    CDK14
    CDK7    CDK6    STK3    CDK15    CDC2L1    CDC2L2

    CDK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CDK1 (see all 403)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs32130221,2
    C,F--62538906(+) AACTCTC/-ATGAG 4 -- int11Minor allele frequency- -:0.46NS 168
    rs32130261,2
    C--62539538(+) GGTATAA/-CTTTG 4 -- int11Minor allele frequency- -:0.01NS 146
    rs105969381,2
    C--62547447(+) ATGAA-/AGAT  
            
    AGAAA
    2 -- int10--------
    rs105822661,2
    C--62547450(+) AAAGA-/TAGA  
            
    AAAGG
    2 -- int11Minor allele frequency- TAGA:0.00NA 2
    rs1125014211,2
    C--62547450(+) AAAGAA/TAGAAA 2 -- int10--------
    rs560147031,2
    C--62553273(+) AAGAATGT/-TGTAA 2 -- int11Minor allele frequency- -:0.50NA 2
    rs1493872811,2
    C--62908566(+) GAAGGA/CCCACT 1 -- us2k10--------
    rs1497094521,2
    --62908650(+) ACATTG/TCCCTG 1 -- us2k10--------
    rs1862385761,2
    --62908776(+) CAGTGC/TTGCAC 4 -- us2k10--------
    rs618532691,2
    C--62908875(+) TTTATA/CAAGAA 4 -- us2k14Minor allele frequency- C:0.11NA WA EA 360

    HapMap Linkage Disequilibrium report for CDK1 (62538089 - 62554610 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CDK1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDK1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 116940    OMIM disorders: --

    Selected diseases for CDK1 (see all 96):    
    About MalaCards
    thyroid lymphoma    myxofibrosarcoma    bloom syndrome    male germ cell tumor
    frontotemporal dementia    cervical intraepithelial neoplasia    smooth muscle tumor    tongue cancer
    bladder transitional cell carcinoma    tuberous sclerosis complex    fanconi's anemia    cervicitis
    spinal cord injury    transitional cell carcinoma    malt lymphoma    tuberous sclerosis
    oral cancer    hereditary spastic paraplegia    melanoma    cutaneous malignant melanoma

    1 disease from the University of Copenhagen DISEASES database for CDK1:
    Retinoblastoma

    CDK1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CDK1 gene (see all 61)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 73.2 34 16465393 (4), 1756735 (1), 8876167 (1), 14674679 (1) (see all 30)
    cancer 57.1 42 8318919 (3), 15645429 (2), 16687918 (2), 17481885 (2) (see all 29)
    tumors 52.2 80 17434927 (3), 18069625 (3), 14696091 (2), 15958646 (2) (see all 54)
    colon cancer 43.5 4 10216486 (2), 15001986 (1), 16024531 (1)
    myeloid leukemia 38.8 2 18505930 (1), 17636382 (1)
    prostate cancer 36.4 18 17070313 (3), 17043241 (2), 15961392 (1), 14652289 (1) (see all 10)
    cervical carcinoma 36.3 1 9201712 (1)
    breast cancer 33.5 23 19239702 (3), 9515786 (2), 11720835 (2), 20010939 (2) (see all 16)
    colon carcinoma 33.5 1 19223178 (1)
    promyelocytic leukemia 32.1 2 16619512 (1), 8936337 (1)

    Genetic Association Database (GAD): CDK1
    Human Genome Epidemiology (HuGE) Navigator: CDK1 (11 documents)

    Export disorders for CDK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDK1 gene, integrated from 10 sources (see all 1534):
    (articles sorted by number of sources associating them with CDK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. (PubMed id 3553962)1, 2, 3 Lee M.G. and Nurse P. (Nature 1987)
    2. New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses. (PubMed id 20395957)1, 2, 9 Yoon C.-H.... Bae Y.-S. (EMBO Rep. 2010)
    3. Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome. (PubMed id 19509060)1, 2, 9 Zhang X....Zhang C. (J. Cell Sci. 2009)
    4. The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2. (PubMed id 9242535)1, 2, 9 Kupfer G.M....D'Andrea A.D. (Blood 1997)
    5. Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition. (PubMed id 20360007)1, 2, 9 Timofeev O.... Hoffmann I. (J. Biol. Chem. 2010)
    6. Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons. (PubMed id 18356527)1, 2, 9 Yuan Z.... Bonni A. (Science 2008)
    7. Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. (PubMed id 16407259)1, 2, 9 Qiao M.... Passaniti A. (J. Biol. Chem. 2006)
    8. Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. (PubMed id 16371510)1, 2, 9 Fourest-Lieuvin A.... Job D. (Mol. Biol. Cell 2006)
    9. T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21. (PubMed id 9515786)1, 2, 9 Ohta T....Xiong Y. (Cancer Res. 1998)
    10. Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance. (PubMed id 21406398)1, 2 Loffler H.... Kramer A. (Cancer Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 983 HGNC: 1722 AceView: CDC2 Ensembl:ENSG00000170312 euGenes: HUgn983
    ECgene: CDK1 Kegg: 983 H-InvDB: CDK1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDK1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cdc2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDK1 gene:
    Search GeneIP for patents involving CDK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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