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Aliases for CDK1 Gene

Aliases for CDK1 Gene

  • Cyclin-Dependent Kinase 1 2 3
  • CDC2 3 4 6
  • Cell Division Cycle 2, G1 To S And G2 To M 2 3
  • Cell Division Control Protein 2 Homolog 3 4
  • Cell Division Protein Kinase 1 3 4
  • P34 Protein Kinase 3 4
  • P34CDC2 3 4
  • CDC28A 3 4
  • Cell Cycle Controller CDC2 3
  • EC 2.7.11.22 4
  • EC 2.7.11.23 4
  • CDKN1 4

External Ids for CDK1 Gene

Previous Symbols for CDK1 Gene

  • CDC2

Summaries for CDK1 Gene

Entrez Gene Summary for CDK1 Gene

  • The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for CDK1 Gene

CDK1 (Cyclin-Dependent Kinase 1) is a Protein Coding gene. Diseases associated with CDK1 include thyroid lymphoma and melanoma. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include protein kinase activity and RNA polymerase II carboxy-terminal domain kinase activity. An important paralog of this gene is CDK4.

UniProtKB/Swiss-Prot for CDK1 Gene

  • Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration.

Tocris Summary for CDK1 Gene

  • Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases, including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability. Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic strategies that block Cdk activity are unlikely to selectively target tumor cells.

Gene Wiki entry for CDK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK1 Gene

Genomics for CDK1 Gene

Genomic Location for CDK1 Gene

Start:
60,772,976 bp from pter
End:
60,794,852 bp from pter
Size:
21,877 bases
Orientation:
Plus strand

Genomic View for CDK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK1 Gene

No data available for Regulatory Elements for CDK1 Gene

Proteins for CDK1 Gene

  • Protein details for CDK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06493-CDK1_HUMAN
    Recommended name:
    Cyclin-dependent kinase 1
    Protein Accession:
    P06493
    Secondary Accessions:
    • A8K7C4
    • C9J497
    • O60764

    Protein attributes for CDK1 Gene

    Size:
    297 amino acids
    Molecular mass:
    34095 Da
    Quaternary structure:
    • Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cyclins-B (CCNB1, CCNB2 and CCNB3) to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Can also form CDK1-cylin-D and CDK1-cyclin-E complexes that phosphorylate RB1 in vitro. Binds to RB1 and other transcription factors such as FOXO1 and RUNX2. Promotes G2-M transition when in complex with a cyclin-B. Interacts with DLGAP5. Binds to the CDK inhibitors CDKN1A/p21 and CDKN1B/p27. Isoform 2 is unable to complex with cyclin-B1 and also fails to bind to CDKN1A/p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase. Associates with cyclins-A and B1 during S-phase in regenerating hepatocytes. Interacts with FANCC. Interacts with CEP63; this interaction recruits CDK1 to centrosomes.
    Miscellaneous:
    • As a key regulator of the cell cycle, CDK1 is a potent therapeutic target for inhibitors in cancer treatment.
    SequenceCaution:
    • Sequence=EAW54204.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDK1 Gene

    Alternative splice isoforms for CDK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDK1 Gene

Proteomics data for CDK1 Gene at MOPED

Post-translational modifications for CDK1 Gene

  • Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1 prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylation by PKMYT1 and WEE1 takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2. By the end of G2, PKMYT1 and WEE1 are inactivated, but CDC25A and CDC25B are activated. Dephosphorylation by active CDC25A and CDC25B at Thr-14 and Tyr-15, leads to CDK1 activation at the G2-M transition. Phosphorylation at Tyr-15 by WEE2 during oogenesis is required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, leading to prevent meiotic reentry. Phosphorylation by WEE2 is also required for metaphase II exit during egg activation to ensure exit from meiosis in oocytes and promote pronuclear formation. Phosphorylated at Tyr-4 by PKR/EIF2AK2 upon genotoxic stress. This phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest. In response to UV irradiation, phosphorylation at Tyr-15 by PRKCD activates the G2/M DNA damage checkpoint.
  • Polyubiquitinated upon genotoxic stress.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys9, Lys20, Lys24, Lys33, Lys34, Lys89, Lys130, Lys139, Lys143, Lys201, Lys238, Lys245, Lys254, Lys266, Lys274, Lys279, and Lys295

Other Protein References for CDK1 Gene

No data available for DME Specific Peptides for CDK1 Gene

Domains for CDK1 Gene

Gene Families for CDK1 Gene

HGNC:
  • CDK :Cyclin-dependent kinases
IUPHAR :

Suggested Antigen Peptide Sequences for CDK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06493

UniProtKB/Swiss-Prot:

CDK1_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P06493
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.:
    • P06493
genes like me logo Genes that share domains with CDK1: view

Function for CDK1 Gene

Molecular function for CDK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it. Activated through a multistep process; binding to cyclin-B is required for relocation of cyclin-kinase complexes to the nucleus, activated by CAK/CDK7-mediated phosphorylation on Thr-161, and CDC25-mediated dephosphorylation of inhibitory phosphorylation on Thr-14 and Tyr-15. Inhibited by flavopiridol and derivatives, pyrimidine derivatives, pyridine derivatives, purine derivatives, staurosporine, paullones, oxoindoles, indazole analogs, indolin-2-ones, pyrazolo[3,4-b]pyridines, imidazo[1,2-a]pyridine (AZ703), thiazolinone analogs(RO-3306), thiazol urea, macrocyclic quinoxalin-2-one, pyrrolo[2,3-a]carbazole, pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine (Dinaciclib, SCH 727965), 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), olomoucine, AG-024322, AT-7519, P276-00, R547/Ro-4584820 and SNS-032/BMS-387032. Repressed by the CDK inhibitors CDKN1A/p21 and CDKN1B/p27 during the G1 phase and by CDKN1A/p21 at the G1-S checkpoint upon DNA damage. Transient activation by rapid and transient dephosphorylation at Tyr-15 triggered by TGFB1.
UniProtKB/Swiss-Prot Function: Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration.
UniProtKB/Swiss-Prot Induction: Follows a cyclic expression; during interphase, accumulates gradually following G1, S to reach a critical threshold at the end of G2, which promotes self-activation and triggers onset of mitosis. Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis, but later repressed. Triggered by CKS1B during mitotic entry in breast cancer cells. Down-regulated under genotoxic stresses triggered by PKR/EIF2AK2-mediated phosphorylation.

Enzyme Numbers (IUBMB) for CDK1 Gene

Gene Ontology (GO) - Molecular Function for CDK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 22854038
GO:0004674 protein serine/threonine kinase activity IDA 11298763
GO:0004693 cyclin-dependent protein serine/threonine kinase activity TAS --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 10373560
genes like me logo Genes that share ontologies with CDK1: view
genes like me logo Genes that share phenotypes with CDK1: view

Animal Models for CDK1 Gene

MGI Knock Outs for CDK1:

No data available for Transcription Factor Targeting and HOMER Transcription for CDK1 Gene

Localization for CDK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK1 Gene

Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK1 Gene COMPARTMENTS Subcellular localization image for CDK1 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 4
peroxisome 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion TAS 19917720
GO:0005813 centrosome IDA 17488717
genes like me logo Genes that share ontologies with CDK1: view

Pathways for CDK1 Gene

SuperPathways for CDK1 Gene

Superpath Contained pathways
1 Signaling by FGFR
2 Insulin receptor signalling cascade
3 SHC1 events in ERBB2 signaling
4 Regulation of PLK1 Activity at G2/M Transition
5 CDK-mediated phosphorylation and removal of Cdc6
genes like me logo Genes that share pathways with CDK1: view

Gene Ontology (GO) - Biological Process for CDK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
genes like me logo Genes that share ontologies with CDK1: view

Compounds for CDK1 Gene

(20) ApexBio Compounds for CDK1 Gene

Compound Action Cas Number
AT7519 novel small molecule effective as a multi-cyclin-dependent kinase inhibitor [844442-38-2]
AZD-5438 Potent CDK1/2/9 inhibitor [602306-29-6]
BMS265246 potent and selective Cdk1/Cdk2 inhibitor [582315-72-8]
BS-181 HCl small molecule inhibitor which is highly selective for Cdk7 activity [1397219-81-6]
Deferasirox rationally-designed oral iron chelator. [201530-41-8]
Dinaciclib (SCH727965) CDK inhibitor [779353-01-4]
Flavopiridol hydrochloride pan-cdk inhibitor. [131740-09-5]
LEE011 orally available CDK inhibitor. [1211441-98-3]
LY2835219 orally available CDK inhibitor, targets the CDK4 and CDK6 [1231930-82-7]
Nu 6027 potent inhibitor of cellular ATR activity [220036-08-8]
Palbociclib (PD0332991) Isethionate Highly selective CDK4/6 inhibitor [827022-33-3]
PD 0332991 (Palbociclib) HCl Highly selective CDK4/6 inhibitor [827022-33-3]
PHA-793887 novel pan-Cdk inhibitor [718630-59-2]
PHA-848125 potent, ATP-competitive Cdk2/cyclin A inhibitor. [802539-81-7]
Purvalanol B cyclin-dependent kinase inhibitor. [212844-54-7]
R547 novel, selective inhibitor of cell cycle and transcriptional CDK. [741713-40-6]
Roscovitine (Seliciclib,CYC202) potent and selective inhibitor of cyclin-dependent kinases [186692-46-6]
SB1317 novel pyrimidine-based multi-kinase inhibitor that inhibits CDKs 1, 2, 7 and 9 together with JAK2 and FLT3 [937270-47-8]
SCH900776 S-isomer potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 [891494-64-7]
SNS-032 (BMS-387032) Potent and selective CDK inhibitor [345627-80-7]

(5) Tocris Compounds for CDK1 Gene

Compound Action Cas Number
Kenpaullone Potent cyclin-dependent kinase inhibitor. Also inhibits GSK-3 [142273-20-9]
Purvalanol A Cyclin-dependent kinase inhibitor [212844-53-6]
Purvalanol B Cyclin-dependent kinase inhibitor [212844-54-7]
Ro 3306 Cyclin-dependent kinase (cdk) 1 inhibitor [872573-93-8]
SU 9516 Potent cdk2 inhibitor [377090-84-1]

(6) Drugbank Compounds for CDK1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alsterpaullone
target inhibitor
Flavopiridol
  • Alvocidib
131740-09-5 target
Hymenialdisine
target
Indirubin-3'-Monoxime
target binder
Olomoucine
101622-51-9 target binder

(125) Novoseek inferred chemical compound relationships for CDK1 Gene

Compound -log(P) Hits PubMed IDs
roscovitine 84.4 40
olomoucine 83.2 15
nu2058 82.2 2
butyrolactone i 76.9 8
flavopiridol 69.9 11
genes like me logo Genes that share compounds with CDK1: view

Transcripts for CDK1 Gene

Unigene Clusters for CDK1 Gene

Cyclin-dependent kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6:
SP7:

Relevant External Links for CDK1 Gene

GeneLoc Exon Structure for
CDK1
ECgene alternative splicing isoforms for
CDK1

Expression for CDK1 Gene

mRNA expression in normal human tissues for CDK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDK1 Gene

This gene is overexpressed in Esophagus - Mucosa (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDK1 Gene

SOURCE GeneReport for Unigene cluster for CDK1 Gene Hs.732435

mRNA Expression by UniProt/SwissProt for CDK1 Gene

P06493-CDK1_HUMAN
Tissue specificity: Isoform 2 is found in breast cancer tissues
genes like me logo Genes that share expressions with CDK1: view

Orthologs for CDK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK1 35
  • 99.89 (n)
  • 100 (a)
CDK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK1 35
  • 95.29 (n)
  • 98.65 (a)
CDK1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK1 35
  • 95.74 (n)
  • 99.33 (a)
CDK1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk1 35
  • 86.08 (n)
  • 96.97 (a)
Cdk1 16
Cdk1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CDK1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk1 35
  • 84.62 (n)
  • 97.64 (a)
chicken
(Gallus gallus)
Aves CDK1 35
  • 80.36 (n)
  • 93.27 (a)
CDK1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDK1 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cdc2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk1 35
  • 75.71 (n)
  • 89.15 (a)
MGC76203 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.631 35
zebrafish
(Danio rerio)
Actinopterygii cdk1 35
  • 73.65 (n)
  • 84.88 (a)
cdk1 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009459 35
  • 60.71 (n)
  • 71.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta cdc2 35
  • 63.08 (n)
  • 73.96 (a)
cdc2 36
  • 72 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cdk-1 35
  • 61.64 (n)
  • 66.1 (a)
cdk-1 36
  • 58 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC28 36
  • 59 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2773 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2145 36
  • 73 (a)
OneToOne
Species with no ortholog for CDK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK1 Gene

ENSEMBL:
Gene Tree for CDK1 (if available)
TreeFam:
Gene Tree for CDK1 (if available)

Paralogs for CDK1 Gene

Paralogs for CDK1 Gene

genes like me logo Genes that share paralogs with CDK1: view

Variants for CDK1 Gene

Sequence variations from dbSNP and Humsavar for CDK1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs8755 -- 60,784,842(+) AACTT(C/G/T)GTCAT reference, missense
rs10711 -- 60,794,716(+) AGGAG(G/T)TGCTT utr-variant-3-prime
rs744383 -- 60,777,020(+) TCTGT(C/T)GCCTA upstream-variant-2KB, intron-variant
rs998826 -- 60,774,869(-) AAAAA(A/T)TTTAA intron-variant
rs1060373 -- 60,794,742(+) TCTGA(A/G)TTTAA utr-variant-3-prime

Relevant External Links for CDK1 Gene

HapMap Linkage Disequilibrium report
CDK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDK1 Gene

Disorders for CDK1 Gene

(1) University of Copenhagen DISEASES for CDK1 Gene

(61) Novoseek inferred disease relationships for CDK1 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 73.2 33
cancer 57.1 35
tumors 52.2 66
colon cancer 43.5 4
myeloid leukemia 38.8 2

Relevant External Links for CDK1

Genetic Association Database (GAD)
CDK1
Human Genome Epidemiology (HuGE) Navigator
CDK1
genes like me logo Genes that share disorders with CDK1: view

No data available for UniProtKB/Swiss-Prot for CDK1 Gene

Publications for CDK1 Gene

  1. T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21. (PMID: 9515786) Ohta T. … Xiong Y. (Cancer Res. 1998) 3 4 23
  2. The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2. (PMID: 9242535) Kupfer G.M. … D'Andrea A.D. (Blood 1997) 3 4 23
  3. Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. (PMID: 16371510) Fourest-Lieuvin A. … Job D. (Mol. Biol. Cell 2006) 3 4 23
  4. Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. (PMID: 16407259) Qiao M. … Passaniti A. (J. Biol. Chem. 2006) 3 4 23
  5. Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. (PMID: 3553962) Lee M.G. … Nurse P. (Nature 1987) 2 3 4

Products for CDK1 Gene

  • Addgene plasmids for CDK1

Sources for CDK1 Gene

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