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Aliases for CDIPT Gene

Aliases for CDIPT Gene

  • CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase 2 3 5
  • Phosphatidylinositol Synthase 2 3 4
  • PtdIns Synthase 3 4
  • PI Synthase 3 4
  • PIS1 3 4
  • PIS 3 4
  • CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase (Phosphatidylinositol Synthase) 2
  • EC 2.7.8.11 4

External Ids for CDIPT Gene

Previous GeneCards Identifiers for CDIPT Gene

  • GC16P029286
  • GC16M030192
  • GC16M029868
  • GC16M029907
  • GC16M029777
  • GC16M027530

Summaries for CDIPT Gene

Entrez Gene Summary for CDIPT Gene

  • Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for CDIPT Gene

CDIPT (CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase) is a Protein Coding gene. Diseases associated with CDIPT include Fibromuscular Dysplasia and Hemoglobin C Disease. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include carbohydrate binding and manganese ion binding.

UniProtKB/Swiss-Prot for CDIPT Gene

  • Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.

Gene Wiki entry for CDIPT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDIPT Gene

Genomics for CDIPT Gene

Regulatory Elements for CDIPT Gene

Enhancers for CDIPT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F030555 1.2 Ensembl ENCODE 32.5 -694.3 -694336 4.2 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC ENSG00000260267 ZNF764 SMG1P2 NPIPB13 ENSG00000260304 ZNF785 BCL7C MIR762HG ENSG00000261474 PRR14
GH16F030052 0.2 ENCODE 23.5 -190.5 -190469 3.1 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 ZNF747 ZNF764 SMG1P2 NPIPB13 BCL7C ZNF785 PRR14 ZNF629 ZNF689 ENSG00000235560
GH16F030785 0.2 ENCODE 23.5 -923.0 -923002 3.4 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF143 ENSG00000260267 ENSG00000260304 ZNF764 BCL7C NPIPB13 ZNF747 PRR14 ZNF720 ENSG00000235560 CDIPT
GH16F030566 0.9 FANTOM5 ENCODE 23.5 -706.1 -706139 6.0 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF302 ENSG00000260267 NPIPB13 ZNF747 SMG1P2 ZNF764 ENSG00000260304 BCL7C ENSG00000261474 ZNF785 ENSG00000235560
GH16F029258 1.3 FANTOM5 Ensembl ENCODE 23.3 +599.1 599109 11.3 HDGF PKNOX1 ARNT MLX ARID4B SIN3A YBX1 FOS SP3 MXD4 ENSG00000260853 MIR4517 SMG1P2 ENSG00000260367 SGF29 NPIPB13 CDIPT ENSG00000260953 ENSG00000261766 NPIPB11
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CDIPT on UCSC Golden Path with GeneCards custom track

Promoters for CDIPT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051754 836 2201 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for CDIPT Gene

Chromosome:
16
Start:
29,858,356 bp from pter
End:
29,863,736 bp from pter
Size:
5,381 bases
Orientation:
Minus strand

Genomic View for CDIPT Gene

Genes around CDIPT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDIPT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDIPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDIPT Gene

Proteins for CDIPT Gene

  • Protein details for CDIPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14735-CDIPT_HUMAN
    Recommended name:
    CDP-diacylglycerol--inositol 3-phosphatidyltransferase
    Protein Accession:
    O14735
    Secondary Accessions:
    • B4DUV0
    • H3BTV1
    • Q6FGU1
    • Q6ZN70

    Protein attributes for CDIPT Gene

    Size:
    213 amino acids
    Molecular mass:
    23539 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDIPT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDIPT Gene

Post-translational modifications for CDIPT Gene

  • Ubiquitination at Lys 121
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDIPT Gene

Domains & Families for CDIPT Gene

Protein Domains for CDIPT Gene

Graphical View of Domain Structure for InterPro Entry

O14735

UniProtKB/Swiss-Prot:

CDIPT_HUMAN :
  • Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
Family:
  • Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
genes like me logo Genes that share domains with CDIPT: view

No data available for Gene Families for CDIPT Gene

Function for CDIPT Gene

Molecular function for CDIPT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 9.0. {ECO:0000269 PubMed:8110188}; Temperature dependence: Optimum temperature is 50 degrees Celsius. {ECO:0000269 PubMed:8110188};
UniProtKB/Swiss-Prot CatalyticActivity:
CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by PtdIns (product inhibition), phosphatidylinositol phosphate, and nucleoside di- and tri-phosphates.
UniProtKB/Swiss-Prot Function:
Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.

Enzyme Numbers (IUBMB) for CDIPT Gene

Gene Ontology (GO) - Molecular Function for CDIPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IDA,TAS --
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016780 phosphotransferase activity, for other substituted phosphate groups IEA --
GO:0019992 diacylglycerol binding IEA --
genes like me logo Genes that share ontologies with CDIPT: view
genes like me logo Genes that share phenotypes with CDIPT: view

Animal Models for CDIPT Gene

MGI Knock Outs for CDIPT:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDIPT

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDIPT Gene

Localization for CDIPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDIPT Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDIPT Gene COMPARTMENTS Subcellular localization image for CDIPT gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
golgi apparatus 3
cytosol 2
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CDIPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0005794 Golgi apparatus IEA,IBA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CDIPT: view

Pathways & Interactions for CDIPT Gene

genes like me logo Genes that share pathways with CDIPT: view

Gene Ontology (GO) - Biological Process for CDIPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006661 phosphatidylinositol biosynthetic process IDA,TAS --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0046341 CDP-diacylglycerol metabolic process IEA --
genes like me logo Genes that share ontologies with CDIPT: view

No data available for SIGNOR curated interactions for CDIPT Gene

Drugs & Compounds for CDIPT Gene

(11) Drugs for CDIPT Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 34
Myo-Inositol Experimental Pharma Target, inhibitor 0
Magnesium Nutra 0

(46) Additional Compounds for CDIPT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CDP-DG(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-CDP
  • 1,2-Dipalmitoyl-rac-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/16:0)
  • CDP-DG(32:0)
  • CDP-Diacylglycerol(16:0/16:0)
CDP-DG(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-CDP
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:0)
  • CDP-DG(34:0)
  • CDP-Diacylglycerol(16:0/18:0)
CDP-DG(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1n7)
  • CDP-DG(16:0/18:1w7)
CDP-DG(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1n9)
  • CDP-DG(16:0/18:1w9)
CDP-DG(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:2)
  • CDP-DG(16:0/18:2n6)
  • CDP-DG(16:0/18:2w6)
genes like me logo Genes that share compounds with CDIPT: view

Transcripts for CDIPT Gene

Unigene Clusters for CDIPT Gene

CDP-diacylglycerol--inositol 3-phosphatidyltransferase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDIPT Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - -
SP7: -
SP8:

Relevant External Links for CDIPT Gene

GeneLoc Exon Structure for
CDIPT
ECgene alternative splicing isoforms for
CDIPT

Expression for CDIPT Gene

mRNA expression in normal human tissues for CDIPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDIPT Gene

This gene is overexpressed in Nasal epithelium (41.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDIPT Gene



Protein tissue co-expression partners for CDIPT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDIPT Gene:

CDIPT

SOURCE GeneReport for Unigene cluster for CDIPT Gene:

Hs.121549

mRNA Expression by UniProt/SwissProt for CDIPT Gene:

O14735-CDIPT_HUMAN
Tissue specificity: Detected in placenta (at protein level). Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. In fetus, expressed in kidney, liver, lung and brain.
genes like me logo Genes that share expression patterns with CDIPT: view

Primer Products

No data available for mRNA differential expression in normal tissues for CDIPT Gene

Orthologs for CDIPT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDIPT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDIPT 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia CDIPT 34 35
  • 90.77 (n)
dog
(Canis familiaris)
Mammalia CDIPT 34 35
  • 90.45 (n)
mouse
(Mus musculus)
Mammalia Cdipt 34 16 35
  • 89.51 (n)
oppossum
(Monodelphis domestica)
Mammalia CDIPT 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdipt 34
  • 87.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDIPT 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDIPT 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdipt 34
  • 74.02 (n)
zebrafish
(Danio rerio)
Actinopterygii cdipt 34 35
  • 67.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003478 34
  • 58.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pis 34 35
  • 58.09 (n)
CG9245 36
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea pisy-1 34 35
  • 54.05 (n)
Y46G5A.5 36
  • 47 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR037W 34
  • 49.28 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PIS1 34 35 37
  • 49.01 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15037g 34
  • 46.09 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PIS1 34
  • 44.28 (n)
rice
(Oryza sativa)
Liliopsida Os02g0123600 34
  • 49.05 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09192 34
  • 57.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToMany
-- 35
  • 46 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pis1 34
  • 48.67 (n)
Species where no ortholog for CDIPT was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDIPT Gene

ENSEMBL:
Gene Tree for CDIPT (if available)
TreeFam:
Gene Tree for CDIPT (if available)

Paralogs for CDIPT Gene

No data available for Paralogs for CDIPT Gene

Variants for CDIPT Gene

Sequence variations from dbSNP and Humsavar for CDIPT Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111849392 -- 29,862,239(+) GCGAC(A/G)CTGCA intron-variant, upstream-variant-2KB
rs113404632 -- 29,860,555(+) CTGAG(A/G)GGTGG intron-variant
rs114293898 -- 29,858,094(+) CTTGA(A/G)TTTGC downstream-variant-500B
rs114923885 -- 29,860,585(+) CCCTC(A/G)AGGTG reference, missense
rs114948991 -- 29,863,991(+) GTTTC(C/T)ACCCA intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDIPT Gene

Variant ID Type Subtype PubMed ID
esv3638373 CNV loss 21293372
nsv457482 CNV loss 19166990
nsv518568 CNV gain 19592680
nsv571818 CNV loss 21841781
nsv833186 CNV loss 17160897

Variation tolerance for CDIPT Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDIPT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDIPT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDIPT Gene

Disorders for CDIPT Gene

MalaCards: The human disease database

(3) MalaCards diseases for CDIPT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fibromuscular dysplasia
  • frontometaphyseal dysplasia
hemoglobin c disease
  • hb-c disease
byssinosis
  • cotton mill fever
- elite association - COSMIC cancer census association via MalaCards
Search CDIPT in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDIPT

Genetic Association Database (GAD)
CDIPT
Human Genome Epidemiology (HuGE) Navigator
CDIPT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDIPT
genes like me logo Genes that share disorders with CDIPT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDIPT Gene

Publications for CDIPT Gene

  1. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. (PMID: 9407135) Lykidis A. … Jackowski S. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. Purification and characterization of phosphatidylinositol synthase from human placenta. (PMID: 8110188) Antonsson B.E. (Biochem. J. 1994) 3 4 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CDIPT Gene

Sources for CDIPT Gene

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