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Aliases for CDIPT Gene

Aliases for CDIPT Gene

  • CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase 2 3 5
  • Phosphatidylinositol Synthase 2 3 4
  • PtdIns Synthase 3 4
  • PI Synthase 3 4
  • PIS1 3 4
  • PIS 3 4
  • CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase (Phosphatidylinositol Synthase) 2
  • EC 4

External Ids for CDIPT Gene

Previous GeneCards Identifiers for CDIPT Gene

  • GC16P029286
  • GC16M030192
  • GC16M029868
  • GC16M029907
  • GC16M029777
  • GC16M027530

Summaries for CDIPT Gene

Entrez Gene Summary for CDIPT Gene

  • Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for CDIPT Gene

CDIPT (CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase) is a Protein Coding gene. Diseases associated with CDIPT include Epilepsy, Familial Temporal Lobe, 2 and Fibromuscular Dysplasia. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include carbohydrate binding and manganese ion binding.

UniProtKB/Swiss-Prot for CDIPT Gene

  • Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.

Gene Wiki entry for CDIPT Gene

Additional gene information for CDIPT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDIPT Gene

Genomics for CDIPT Gene

Regulatory Elements for CDIPT Gene

Enhancers for CDIPT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H030566 2.1 FANTOM5 Ensembl ENCODE dbSUPER 23.5 -706.1 -706139 6 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZC3H11A SETD1A SRCAP ENSG00000260267 ZNF747 NPIPB13 INO80E ZNF764 C16orf58 SMG1P5 SMG1P2
GH16H029273 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.3 +589.8 589836 0.6 HDGF PKNOX1 FOXA2 ARNT YBX1 ZBTB7B TCF12 ZNF207 FOS ATF7 NPIPB12 ENSG00000260853 ATXN2L INO80E NPIPB13 SPNS1 ENSG00000261766 ENSG00000260796 NFATC2IP ENSG00000198106
GH16H029942 1.7 FANTOM5 Ensembl ENCODE 21.5 -80.2 -80247 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B ZNF766 INO80E SRCAP ENSG00000260853 NPIPB12 SPNS1 NFATC2IP ENSG00000260367 ZNF785 SMG1P5 SMG1P2
GH16H030052 1.4 ENCODE dbSUPER 23.5 -190.5 -190469 3.1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZC3H11A SETD1A SRCAP INO80E NPIPB12 ZNF747 ZNF764 SMG1P5 SMG1P2 NPIPB13 BCL7C
GH16H030785 1.1 ENCODE 23.5 -923.0 -923002 3.4 MLX ZFP64 ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 ZNF143 ZNF548 SRCAP SETD1A INO80E ENSG00000260267 SMG1P5 FUS ZNF764 ENSG00000260304 ZNF747 BCL7C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDIPT on UCSC Golden Path with GeneCards custom track

Promoters for CDIPT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for CDIPT Gene

Genomic Locations for CDIPT Gene
5,381 bases
Minus strand

Genomic View for CDIPT Gene

Genes around CDIPT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDIPT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDIPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDIPT Gene

Proteins for CDIPT Gene

  • Protein details for CDIPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CDP-diacylglycerol--inositol 3-phosphatidyltransferase
    Protein Accession:
    Secondary Accessions:
    • B4DUV0
    • H3BTV1
    • Q6FGU1
    • Q6ZN70

    Protein attributes for CDIPT Gene

    213 amino acids
    Molecular mass:
    23539 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDIPT Gene


neXtProt entry for CDIPT Gene

Post-translational modifications for CDIPT Gene

  • Ubiquitination at posLast=121121
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDIPT Gene

Domains & Families for CDIPT Gene

Gene Families for CDIPT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for CDIPT Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  • Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
genes like me logo Genes that share domains with CDIPT: view

Function for CDIPT Gene

Molecular function for CDIPT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 9.0. {ECO:0000269 PubMed:8110188}; Temperature dependence: Optimum temperature is 50 degrees Celsius. {ECO:0000269 PubMed:8110188};
UniProtKB/Swiss-Prot CatalyticActivity:
CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by PtdIns (product inhibition), phosphatidylinositol phosphate, and nucleoside di- and tri-phosphates.
UniProtKB/Swiss-Prot Function:
Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.

Enzyme Numbers (IUBMB) for CDIPT Gene

Phenotypes From GWAS Catalog for CDIPT Gene

Gene Ontology (GO) - Molecular Function for CDIPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016780 phosphotransferase activity, for other substituted phosphate groups IEA --
GO:0019992 diacylglycerol binding IEA --
genes like me logo Genes that share ontologies with CDIPT: view
genes like me logo Genes that share phenotypes with CDIPT: view

Animal Models for CDIPT Gene

MGI Knock Outs for CDIPT:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDIPT Gene

Localization for CDIPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDIPT Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDIPT gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
nucleus 3
golgi apparatus 3
extracellular 2
cytosol 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDIPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IBA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CDIPT: view

Pathways & Interactions for CDIPT Gene

genes like me logo Genes that share pathways with CDIPT: view

Gene Ontology (GO) - Biological Process for CDIPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006661 phosphatidylinositol biosynthetic process TAS,IDA --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0046341 CDP-diacylglycerol metabolic process IEA --
genes like me logo Genes that share ontologies with CDIPT: view

No data available for SIGNOR curated interactions for CDIPT Gene

Drugs & Compounds for CDIPT Gene

(12) Drugs for CDIPT Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 35
Cytidine monophosphate Experimental Pharma 0
Inositol Investigational Nutra 90
Scyllitol Investigational Pharma Target, inhibitor 0
Magnesium Nutra 0

(44) Additional Compounds for CDIPT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,2-Dihexadecanoyl-rac-glycero-3-CDP
  • 1,2-Dipalmitoyl-rac-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/16:0)
  • CDP-DG(32:0)
  • CDP-Diacylglycerol(16:0/16:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-CDP
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:0)
  • CDP-DG(34:0)
  • CDP-Diacylglycerol(16:0/18:0)
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1n7)
  • CDP-DG(16:0/18:1w7)
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1n9)
  • CDP-DG(16:0/18:1w9)
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:2)
  • CDP-DG(16:0/18:2n6)
  • CDP-DG(16:0/18:2w6)
genes like me logo Genes that share compounds with CDIPT: view

Transcripts for CDIPT Gene

Unigene Clusters for CDIPT Gene

CDP-diacylglycerol--inositol 3-phosphatidyltransferase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDIPT Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - -
SP7: -

Relevant External Links for CDIPT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDIPT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDIPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDIPT Gene

This gene is overexpressed in Nasal epithelium (41.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDIPT Gene

Protein tissue co-expression partners for CDIPT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDIPT Gene:


SOURCE GeneReport for Unigene cluster for CDIPT Gene:


mRNA Expression by UniProt/SwissProt for CDIPT Gene:

Tissue specificity: Detected in placenta (at protein level). Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. In fetus, expressed in kidney, liver, lung and brain.

Evidence on tissue expression from TISSUES for CDIPT Gene

  • Nervous system(4.6)
  • Lung(3.3)
  • Blood(2.8)
  • Kidney(2.7)
  • Liver(2.5)
  • Eye(2.4)
  • Muscle(2.3)
  • Intestine(2.2)
  • Heart(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with CDIPT: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDIPT Gene

Orthologs for CDIPT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDIPT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDIPT 33 34
  • 100 (n)
(Bos Taurus)
Mammalia CDIPT 33 34
  • 90.77 (n)
(Canis familiaris)
Mammalia CDIPT 33 34
  • 90.45 (n)
(Mus musculus)
Mammalia Cdipt 33 16 34
  • 89.51 (n)
(Monodelphis domestica)
Mammalia CDIPT 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Cdipt 33
  • 87.64 (n)
(Ornithorhynchus anatinus)
Mammalia CDIPT 34
  • 86 (a)
(Anolis carolinensis)
Reptilia CDIPT 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdipt 33
  • 74.02 (n)
(Danio rerio)
Actinopterygii cdipt 33 34
  • 67.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003478 33
  • 58.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pis 33 34
  • 58.09 (n)
CG9245 35
  • 50 (a)
(Caenorhabditis elegans)
Secernentea pisy-1 33 34
  • 54.05 (n)
Y46G5A.5 35
  • 47 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR037W 33
  • 49.28 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PIS1 33 34 36
  • 49.01 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15037g 33
  • 46.09 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PIS1 33
  • 44.28 (n)
(Oryza sativa)
Liliopsida Os02g0123600 33
  • 49.05 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09192 33
  • 57.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
-- 34
  • 46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pis1 33
  • 48.67 (n)
Species where no ortholog for CDIPT was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDIPT Gene

Gene Tree for CDIPT (if available)
Gene Tree for CDIPT (if available)

Paralogs for CDIPT Gene

No data available for Paralogs for CDIPT Gene

Variants for CDIPT Gene

Sequence variations from dbSNP and Humsavar for CDIPT Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000556536 -- 29,863,854(+) TTTAT(A/G)GCGTC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000672613 -- 29,860,240(+) GCCAC(C/T)ATGCC intron-variant
rs1001874080 -- 29,858,013(+) GGCCT(C/T)GAACT downstream-variant-500B
rs1002426899 -- 29,864,478(+) AGCCA(C/T)GGGCC intron-variant, upstream-variant-2KB
rs1003247056 -- 29,862,917(+) AGCCC(C/G)GCAGC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CDIPT Gene

Variant ID Type Subtype PubMed ID
nsv833186 CNV loss 17160897
nsv571818 CNV loss 21841781
nsv518568 CNV gain 19592680
nsv457482 CNV loss 19166990
esv3638373 CNV loss 21293372

Variation tolerance for CDIPT Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDIPT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDIPT Gene

Disorders for CDIPT Gene

MalaCards: The human disease database

(5) MalaCards diseases for CDIPT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
epilepsy, familial temporal lobe, 2
  • familial temporal lobe epilepsy 2
fibromuscular dysplasia
  • fibromuscular dysplasia of arteries
hemoglobin c disease
  • hb-c disease
wilson-turner syndrome
  • mental retardation, x-linked, syndromic 6
  • cotton mill fever
- elite association - COSMIC cancer census association via MalaCards
Search CDIPT in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDIPT

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDIPT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDIPT Gene

Publications for CDIPT Gene

  1. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. (PMID: 9407135) Lykidis A … Jackowski S (The Journal of biological chemistry 1997) 2 3 4 22 60
  2. Purification and characterization of phosphatidylinositol synthase from human placenta. (PMID: 8110188) Antonsson BE (The Biochemical journal 1994) 3 4 22 60
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for CDIPT Gene

Sources for CDIPT Gene