Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDIPT Gene

Aliases for CDIPT Gene

  • CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase 2 3 5
  • Phosphatidylinositol Synthase 2 3 4
  • PtdIns Synthase 3 4
  • PI Synthase 3 4
  • PIS1 3 4
  • PIS 3 4
  • CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase (Phosphatidylinositol Synthase) 2
  • EC 2.7.8.11 4

External Ids for CDIPT Gene

Previous GeneCards Identifiers for CDIPT Gene

  • GC16P029286
  • GC16M030192
  • GC16M029868
  • GC16M029907
  • GC16M029777
  • GC16M027530

Summaries for CDIPT Gene

Entrez Gene Summary for CDIPT Gene

  • Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for CDIPT Gene

CDIPT (CDP-Diacylglycerol--Inositol 3-Phosphatidyltransferase) is a Protein Coding gene. Diseases associated with CDIPT include fibromuscular dysplasia and hemoglobin c disease. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include carbohydrate binding and manganese ion binding.

UniProtKB/Swiss-Prot for CDIPT Gene

  • Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.

Gene Wiki entry for CDIPT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDIPT Gene

Genomics for CDIPT Gene

Regulatory Elements for CDIPT Gene

Promoters for CDIPT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDIPT on UCSC Golden Path with GeneCards custom track

Genomic Location for CDIPT Gene

Chromosome:
16
Start:
29,858,356 bp from pter
End:
29,863,736 bp from pter
Size:
5,381 bases
Orientation:
Minus strand

Genomic View for CDIPT Gene

Genes around CDIPT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDIPT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDIPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDIPT Gene

Proteins for CDIPT Gene

  • Protein details for CDIPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14735-CDIPT_HUMAN
    Recommended name:
    CDP-diacylglycerol--inositol 3-phosphatidyltransferase
    Protein Accession:
    O14735
    Secondary Accessions:
    • B4DUV0
    • H3BTV1
    • Q6FGU1
    • Q6ZN70

    Protein attributes for CDIPT Gene

    Size:
    213 amino acids
    Molecular mass:
    23539 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDIPT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDIPT Gene

Proteomics data for CDIPT Gene at MOPED

Post-translational modifications for CDIPT Gene

  • Ubiquitination at Lys 121
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDIPT Gene

Domains & Families for CDIPT Gene

Protein Domains for CDIPT Gene

Graphical View of Domain Structure for InterPro Entry

O14735

UniProtKB/Swiss-Prot:

CDIPT_HUMAN :
  • Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
Family:
  • Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
genes like me logo Genes that share domains with CDIPT: view

No data available for Gene Families for CDIPT Gene

Function for CDIPT Gene

Molecular function for CDIPT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 9.0. {ECO:0000269 PubMed:8110188}; Temperature dependence: Optimum temperature is 50 degrees Celsius. {ECO:0000269 PubMed:8110188};
UniProtKB/Swiss-Prot CatalyticActivity:
CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by PtdIns (product inhibition), phosphatidylinositol phosphate, and nucleoside di- and tri-phosphates.
UniProtKB/Swiss-Prot Function:
Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme.

Enzyme Numbers (IUBMB) for CDIPT Gene

Gene Ontology (GO) - Molecular Function for CDIPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity TAS --
GO:0019992 diacylglycerol binding IEA --
genes like me logo Genes that share ontologies with CDIPT: view
genes like me logo Genes that share phenotypes with CDIPT: view

Animal Models for CDIPT Gene

MGI Knock Outs for CDIPT:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDIPT Gene

Localization for CDIPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDIPT Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDIPT Gene COMPARTMENTS Subcellular localization image for CDIPT gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
golgi apparatus 3
cytosol 2
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CDIPT Gene

Pathways & Interactions for CDIPT Gene

genes like me logo Genes that share pathways with CDIPT: view

Gene Ontology (GO) - Biological Process for CDIPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0008654 phospholipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with CDIPT: view

No data available for SIGNOR curated interactions for CDIPT Gene

Drugs & Compounds for CDIPT Gene

(10) Drugs for CDIPT Gene - From: Novoseek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Myo-Inositol Experimental Pharma Target, inhibitor 0
Manganese Pharma 32
Magnesium Nutra 0

(47) Additional Compounds for CDIPT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CDP-DG(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-CDP
  • 1,2-Dipalmitoyl-rac-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/16:0)
  • CDP-DG(32:0)
  • CDP-Diacylglycerol(16:0/16:0)
CDP-DG(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-CDP
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:0)
  • CDP-DG(34:0)
  • CDP-Diacylglycerol(16:0/18:0)
CDP-DG(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1n7)
  • CDP-DG(16:0/18:1w7)
CDP-DG(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1n9)
  • CDP-DG(16:0/18:1w9)
CDP-DG(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:2)
  • CDP-DG(16:0/18:2n6)
  • CDP-DG(16:0/18:2w6)
genes like me logo Genes that share compounds with CDIPT: view

Transcripts for CDIPT Gene

Unigene Clusters for CDIPT Gene

CDP-diacylglycerol--inositol 3-phosphatidyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDIPT Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - -
SP7: -
SP8:

Relevant External Links for CDIPT Gene

GeneLoc Exon Structure for
CDIPT
ECgene alternative splicing isoforms for
CDIPT

Expression for CDIPT Gene

mRNA expression in normal human tissues for CDIPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDIPT Gene

This gene is overexpressed in Nasal epithelium (41.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDIPT Gene



SOURCE GeneReport for Unigene cluster for CDIPT Gene Hs.121549

mRNA Expression by UniProt/SwissProt for CDIPT Gene

O14735-CDIPT_HUMAN
Tissue specificity: Detected in placenta (at protein level). Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. In fetus, expressed in kidney, liver, lung and brain.
genes like me logo Genes that share expression patterns with CDIPT: view

Protein tissue co-expression partners for CDIPT Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDIPT Gene

Orthologs for CDIPT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDIPT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDIPT 35
  • 100 (n)
  • 100 (a)
CDIPT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDIPT 36
  • 96 (a)
OneToOne
CDIPT 35
  • 90.77 (n)
  • 95.77 (a)
dog
(Canis familiaris)
Mammalia CDIPT 35
  • 90.45 (n)
  • 94.37 (a)
CDIPT 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdipt 16
Cdipt 35
  • 89.51 (n)
  • 96.24 (a)
Cdipt 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDIPT 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDIPT 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdipt 35
  • 87.64 (n)
  • 95.31 (a)
lizard
(Anolis carolinensis)
Reptilia CDIPT 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdipt 35
  • 74.02 (n)
  • 75.59 (a)
zebrafish
(Danio rerio)
Actinopterygii cdipt 35
  • 67.46 (n)
  • 71.29 (a)
cdipt 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003478 35
  • 58.61 (n)
  • 54.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9245 37
  • 50 (a)
Pis 35
  • 58.09 (n)
  • 51.94 (a)
Pis 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y46G5A.5 37
  • 47 (a)
pisy-1 35
  • 54.05 (n)
  • 48.54 (a)
pisy-1 36
  • 45 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR037W 35
  • 49.28 (n)
  • 37.2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PIS1 35
  • 49.01 (n)
  • 41.58 (a)
PIS1 36
  • 38 (a)
OneToOne
PIS1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15037g 35
  • 46.09 (n)
  • 38.76 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PIS1 35
  • 44.28 (n)
  • 34.78 (a)
rice
(Oryza sativa)
Liliopsida Os02g0123600 35
  • 49.05 (n)
  • 38.86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09192 35
  • 57.08 (n)
  • 48.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pis1 35
  • 48.67 (n)
  • 43.5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
Species with no ortholog for CDIPT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDIPT Gene

ENSEMBL:
Gene Tree for CDIPT (if available)
TreeFam:
Gene Tree for CDIPT (if available)

Paralogs for CDIPT Gene

No data available for Paralogs for CDIPT Gene

Variants for CDIPT Gene

Sequence variations from dbSNP and Humsavar for CDIPT Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1802002 - 29,859,236(-) CCGCC(C/T)GCAAC reference, missense
rs8335 -- 29,858,427(-) CTTCT(C/G)TATCC utr-variant-3-prime
rs12597540 -- 29,857,978(+) ttgta(A/G)agatg downstream-variant-500B
rs17842263 -- 29,858,541(-) TCCCC(A/C)CCGCC utr-variant-3-prime
rs34121213 -- 29,861,244(-) TGGGG(C/T)CATGC reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CDIPT Gene

Variant ID Type Subtype PubMed ID
nsv833186 CNV Loss 17160897
nsv518568 CNV Gain 19592680
nsv905717 CNV Loss 21882294
nsv457482 CNV Loss 19166990

Variation tolerance for CDIPT Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDIPT Gene

HapMap Linkage Disequilibrium report
CDIPT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDIPT Gene

Disorders for CDIPT Gene

MalaCards: The human disease database

(3) MalaCards diseases for CDIPT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fibromuscular dysplasia
  • frontometaphyseal dysplasia
hemoglobin c disease
  • hb-c disease
byssinosis
  • cotton mill fever
- elite association - COSMIC cancer census association via MalaCards
Search CDIPT in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDIPT

Genetic Association Database (GAD)
CDIPT
Human Genome Epidemiology (HuGE) Navigator
CDIPT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDIPT
genes like me logo Genes that share disorders with CDIPT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDIPT Gene

Publications for CDIPT Gene

  1. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. (PMID: 9407135) Lykidis A. … Jackowski S. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Phosphatidylinositol synthase from mammalian tissues. (PMID: 9370331) Antonsson B. (Biochim. Biophys. Acta 1997) 3 23
  3. Purification and characterization of phosphatidylinositol synthase from human placenta. (PMID: 8110188) Antonsson B.E. (Biochem. J. 1994) 3 23
  4. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CDIPT Gene

Sources for CDIPT Gene

Back to Top

Content