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Aliases for CDIP1 Gene

Aliases for CDIP1 Gene

  • Cell Death Inducing P53 Target 1 2 3 5
  • Cell Death Involved P53-Target 2 3 4
  • Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha-Like Protein 3 4
  • Transmembrane Protein I1 3 4
  • LITAF-Like Protein 3 4
  • C16orf5 3 4
  • LITAFL 3 4
  • CDIP 3 4
  • Lipopolysaccharide-Induced TNF Factor-Like 2
  • Cell Death-Inducing P53-Target Protein 1 3
  • Chromosome 16 Open Reading Frame 5 2
  • Cell Death-Inducing P53 Target 1 2
  • Cell Death Inducing Protein 3
  • Cell Death-Inducing Protein 4
  • I1 3

External Ids for CDIP1 Gene

Previous HGNC Symbols for CDIP1 Gene

  • C16orf5

Previous GeneCards Identifiers for CDIP1 Gene

  • GC16M004560

Summaries for CDIP1 Gene

GeneCards Summary for CDIP1 Gene

CDIP1 (Cell Death Inducing P53 Target 1) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and DNA Damage. An important paralog of this gene is LITAF.

UniProtKB/Swiss-Prot for CDIP1 Gene

  • Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDIP1 Gene

Genomics for CDIP1 Gene

Regulatory Elements for CDIP1 Gene

Enhancers for CDIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F004536 1 FANTOM5 ENCODE 37.7 +0.6 637 2.6 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF302 ZNF500 CDIP1 NMRAL1 CREBBP HMOX2 GLIS2 MGRN1 PPL C16orf96 ENSG00000278434
GH16F004485 1.3 Ensembl ENCODE 30.1 +50.4 50437 6.2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 NMRAL1 CDIP1 HMOX2 CLUAP1 ZNF500 NUDT16L1 GLIS2 CORO7 MGRN1
GH16F004513 1 Ensembl ENCODE 20.4 +23.2 23184 5.1 HDGF PKNOX1 ZNF2 RAD21 ZNF121 ETV6 CREM ZNF654 CBFB JUNB NMRAL1 CDIP1 ZNF500 HMOX2 PPL MGRN1 ENSG00000263235 GC16M004514 PIR61581 GC16P004530
GH16F004473 0.6 ENCODE 17.2 +62.7 62660 5.4 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 CBX5 NMRAL1 ZNF500 CREBBP CDIP1 HMOX2 NUDT16L1 MGRN1
GH16F004499 0.6 Ensembl ENCODE 13.2 +35.3 35332 7.4 HDGF PKNOX1 WRNIP1 INSM2 SIN3A BMI1 FEZF1 ZNF2 RAD21 YY1 NMRAL1 HMOX2 CDIP1 PPL GC16P004506
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CDIP1 on UCSC Golden Path with GeneCards custom track

Promoters for CDIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000502966 628 2000 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF302

Genomic Location for CDIP1 Gene

Chromosome:
16
Start:
4,510,675 bp from pter
End:
4,538,828 bp from pter
Size:
28,154 bases
Orientation:
Minus strand

Genomic View for CDIP1 Gene

Genes around CDIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDIP1 Gene

Proteins for CDIP1 Gene

  • Protein details for CDIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H305-CDIP1_HUMAN
    Recommended name:
    Cell death-inducing p53-target protein 1
    Protein Accession:
    Q9H305
    Secondary Accessions:
    • A8K7M1
    • B4DFU1
    • B4DY75
    • D3DUD6
    • Q96ID8
    • Q9H0Q4
    • Q9P112

    Protein attributes for CDIP1 Gene

    Size:
    208 amino acids
    Molecular mass:
    21892 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF26619.1; Type=Frameshift; Positions=200; Evidence={ECO:0000305};

    Alternative splice isoforms for CDIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDIP1 Gene

Post-translational modifications for CDIP1 Gene

  • Ubiquitination at Lys 21, Lys 198, and Lys 205
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDIP1 Gene

Domains & Families for CDIP1 Gene

Protein Domains for CDIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H305

UniProtKB/Swiss-Prot:

CDIP1_HUMAN :
  • Belongs to the CDIP1/LITAF family.
Family:
  • Belongs to the CDIP1/LITAF family.
genes like me logo Genes that share domains with CDIP1: view

No data available for Gene Families for CDIP1 Gene

Function for CDIP1 Gene

Molecular function for CDIP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.
UniProtKB/Swiss-Prot Induction:
Up-regulated by p53/TP53.

Gene Ontology (GO) - Molecular Function for CDIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CDIP1: view

Animal Model Products

miRNA for CDIP1 Gene

miRTarBase miRNAs that target CDIP1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDIP1 Gene

Localization for CDIP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDIP1 Gene COMPARTMENTS Subcellular localization image for CDIP1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytoskeleton 2
chloroplast 1
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,IDA 10570909
genes like me logo Genes that share ontologies with CDIP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CDIP1 Gene

Pathways & Interactions for CDIP1 Gene

genes like me logo Genes that share pathways with CDIP1: view

Pathways by source for CDIP1 Gene

3 Cell Signaling Technology pathways for CDIP1 Gene

Gene Ontology (GO) - Biological Process for CDIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IGI 17599062
GO:0033209 tumor necrosis factor-mediated signaling pathway IGI 17599062
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP 17599062
genes like me logo Genes that share ontologies with CDIP1: view

No data available for SIGNOR curated interactions for CDIP1 Gene

Transcripts for CDIP1 Gene

Unigene Clusters for CDIP1 Gene

Cell death-inducing p53 target 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4:
SP5: - - - - - - -
SP6: - - - - - -
SP7: - -
SP8: - - -

Relevant External Links for CDIP1 Gene

GeneLoc Exon Structure for
CDIP1
ECgene alternative splicing isoforms for
CDIP1

Expression for CDIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDIP1 Gene

This gene is overexpressed in Frontal cortex (39.0) and Peripheral blood mononuclear cells (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDIP1 Gene



Protein tissue co-expression partners for CDIP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDIP1 Gene:

CDIP1

SOURCE GeneReport for Unigene cluster for CDIP1 Gene:

Hs.654653

mRNA Expression by UniProt/SwissProt for CDIP1 Gene:

Q9H305-CDIP1_HUMAN
Tissue specificity: Highly expressed in brain. Expressed at lower level in heart, skeletal muscle, kidney, pancreas and liver. Weakly or not expressed in placenta and lung.
genes like me logo Genes that share expression patterns with CDIP1: view

Primer Products

No data available for mRNA differential expression in normal tissues for CDIP1 Gene

Orthologs for CDIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16H16ORF5 35
  • 100 (a)
OneToOne
C16H16orf5 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia CDIP1 35
  • 96 (a)
OneToOne
C6H16orf5 34
  • 89.9 (n)
cow
(Bos Taurus)
Mammalia CDIP1 34 35
  • 90.38 (n)
rat
(Rattus norvegicus)
Mammalia Cdip1 34
  • 88.46 (n)
mouse
(Mus musculus)
Mammalia Cdip1 34 16 35
  • 88.14 (n)
oppossum
(Monodelphis domestica)
Mammalia CDIP1 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDIP1 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves C16ORF5 34 35
  • 67.5 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5174 34
African clawed frog
(Xenopus laevis)
Amphibia MGC52765 34
zebrafish
(Danio rerio)
Actinopterygii zgc:165666 34
  • 62.4 (n)
CDIP1 35
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32280 35
  • 35 (a)
ManyToMany
CG13559 35
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F36G3.3 35
  • 26 (a)
OneToMany
Species where no ortholog for CDIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDIP1 Gene

ENSEMBL:
Gene Tree for CDIP1 (if available)
TreeFam:
Gene Tree for CDIP1 (if available)

Paralogs for CDIP1 Gene

Paralogs for CDIP1 Gene

genes like me logo Genes that share paralogs with CDIP1: view

Variants for CDIP1 Gene

Sequence variations from dbSNP and Humsavar for CDIP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10451135 -- 4,530,213(+) TACAC(C/T)ACATT intron-variant
rs10451137 -- 4,530,635(+) CAGAG(C/T)GAGAC intron-variant
rs1051308 -- 4,510,300(+) CCTCC(A/G)CGCTG downstream-variant-500B, utr-variant-3-prime
rs11076836 -- 4,519,330(+) TGGAC(A/G)TCTTC intron-variant
rs11076837 -- 4,519,439(+) TGCGA(C/T)CTGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDIP1 Gene

Variant ID Type Subtype PubMed ID
nsv1046986 CNV gain 25217958

Variation tolerance for CDIP1 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDIP1 Gene

Human Gene Mutation Database (HGMD)
CDIP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDIP1 Gene

Disorders for CDIP1 Gene

Relevant External Links for CDIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDIP1

No disorders were found for CDIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDIP1 Gene

Publications for CDIP1 Gene

  1. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. (PMID: 17599062) Brown L. … Lee S.W. (EMBO J. 2007) 2 3 4 64
  2. C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed in the brain. (PMID: 10570909) Bhalla K. … Callen D.F. (J. Hum. Genet. 1999) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for CDIP1 Gene

Sources for CDIP1 Gene

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