Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDIP1 Gene

Aliases for CDIP1 Gene

  • Cell Death-Inducing P53 Target 1 2 3 5
  • Cell Death Involved P53-Target 2 3 4
  • Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha-Like Protein 3 4
  • Cell Death-Inducing Protein 3 4
  • Transmembrane Protein I1 3 4
  • LITAF-Like Protein 3 4
  • C16orf5 3 4
  • LITAFL 3 4
  • CDIP 3 4
  • Lipopolysaccharide-Induced TNF Factor-Like 2
  • Chromosome 16 Open Reading Frame 5 2
  • Cell Death Inducing Protein 3
  • I1 3

External Ids for CDIP1 Gene

Previous HGNC Symbols for CDIP1 Gene

  • C16orf5

Previous GeneCards Identifiers for CDIP1 Gene

  • GC16M004560

Summaries for CDIP1 Gene

GeneCards Summary for CDIP1 Gene

CDIP1 (Cell Death-Inducing P53 Target 1) is a Protein Coding gene. Among its related pathways are NF-kappaB Signaling and DNA Damage. An important paralog of this gene is LITAF.

UniProtKB/Swiss-Prot for CDIP1 Gene

  • Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDIP1 Gene

Genomics for CDIP1 Gene

Regulatory Elements for CDIP1 Gene

Enhancers for CDIP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDIP1 on UCSC Golden Path with GeneCards custom track

Promoters for CDIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDIP1 Gene

4,510,675 bp from pter
4,538,828 bp from pter
28,154 bases
Minus strand

Genomic View for CDIP1 Gene

Genes around CDIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDIP1 Gene

Proteins for CDIP1 Gene

  • Protein details for CDIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell death-inducing p53-target protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K7M1
    • B4DFU1
    • B4DY75
    • D3DUD6
    • Q96ID8
    • Q9H0Q4
    • Q9P112

    Protein attributes for CDIP1 Gene

    208 amino acids
    Molecular mass:
    21892 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF26619.1; Type=Frameshift; Positions=200; Evidence={ECO:0000305};

    Alternative splice isoforms for CDIP1 Gene


neXtProt entry for CDIP1 Gene

Proteomics data for CDIP1 Gene at MOPED

Post-translational modifications for CDIP1 Gene

  • Ubiquitination at Lys 21, Lys 198, and Lys 205
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDIP1 Gene

Domains & Families for CDIP1 Gene

Protein Domains for CDIP1 Gene


Suggested Antigen Peptide Sequences for CDIP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CDIP1/LITAF family.
  • Belongs to the CDIP1/LITAF family.
genes like me logo Genes that share domains with CDIP1: view

No data available for Gene Families for CDIP1 Gene

Function for CDIP1 Gene

Molecular function for CDIP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.
UniProtKB/Swiss-Prot Induction:
Up-regulated by p53/TP53.

Gene Ontology (GO) - Molecular Function for CDIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CDIP1: view

Animal Model Products

CRISPR Products

miRNA for CDIP1 Gene

miRTarBase miRNAs that target CDIP1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDIP1 Gene

Localization for CDIP1 Gene

Subcellular locations from

Jensen Localization Image for CDIP1 Gene COMPARTMENTS Subcellular localization image for CDIP1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytoskeleton 2
chloroplast 1
cytosol 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CDIP1 Gene

Pathways & Interactions for CDIP1 Gene

genes like me logo Genes that share pathways with CDIP1: view

Pathways by source for CDIP1 Gene

3 Cell Signaling Technology pathways for CDIP1 Gene

Interacting Proteins for CDIP1 Gene

Gene Ontology (GO) - Biological Process for CDIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033209 tumor necrosis factor-mediated signaling pathway IGI 17599062
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP 17599062
genes like me logo Genes that share ontologies with CDIP1: view

No data available for SIGNOR curated interactions for CDIP1 Gene

Drugs & Compounds for CDIP1 Gene

No Compound Related Data Available

Transcripts for CDIP1 Gene

Unigene Clusters for CDIP1 Gene

Cell death-inducing p53 target 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - -
SP8: - - -

Relevant External Links for CDIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDIP1 Gene

mRNA expression in normal human tissues for CDIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDIP1 Gene

This gene is overexpressed in Frontal cortex (39.0) and Peripheral blood mononuclear cells (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDIP1 Gene

SOURCE GeneReport for Unigene cluster for CDIP1 Gene Hs.654653

mRNA Expression by UniProt/SwissProt for CDIP1 Gene

Tissue specificity: Highly expressed in brain. Expressed at lower level in heart, skeletal muscle, kidney, pancreas and liver. Weakly or not expressed in placenta and lung.
genes like me logo Genes that share expression patterns with CDIP1: view

Protein tissue co-expression partners for CDIP1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for CDIP1 Gene

Orthologs for CDIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDIP1 35
  • 90.38 (n)
  • 95.67 (a)
CDIP1 36
  • 96 (a)
(Canis familiaris)
Mammalia C6H16orf5 35
  • 89.9 (n)
  • 95.67 (a)
CDIP1 36
  • 96 (a)
(Mus musculus)
Mammalia Cdip1 35
  • 88.14 (n)
  • 94.23 (a)
Cdip1 16
Cdip1 36
  • 94 (a)
(Pan troglodytes)
Mammalia C16H16orf5 35
  • 99.68 (n)
  • 99.52 (a)
C16H16ORF5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cdip1 35
  • 88.46 (n)
  • 94.23 (a)
(Monodelphis domestica)
Mammalia CDIP1 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia CDIP1 36
  • 69 (a)
(Gallus gallus)
Aves C16ORF5 35
  • 67.5 (n)
  • 67 (a)
C16ORF5 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5174 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52765 35
(Danio rerio)
Actinopterygii zgc:165666 35
  • 62.4 (n)
  • 62.56 (a)
CDIP1 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13559 36
  • 25 (a)
CG32280 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea F36G3.3 36
  • 26 (a)
Species with no ortholog for CDIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDIP1 Gene

Gene Tree for CDIP1 (if available)
Gene Tree for CDIP1 (if available)

Paralogs for CDIP1 Gene

Paralogs for CDIP1 Gene

genes like me logo Genes that share paralogs with CDIP1: view

Variants for CDIP1 Gene

Sequence variations from dbSNP and Humsavar for CDIP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs7665 -- 4,512,511(+) TGAGC(A/G)CAGGG utr-variant-3-prime
rs7702 -- 4,510,928(+) TCTGT(C/G)TTGCT utr-variant-3-prime
rs8129 -- 4,512,350(+) CATTG(C/T)CAGCC utr-variant-3-prime
rs8062952 -- 4,523,228(+) gacac(A/G)tccct intron-variant
rs13330016 -- 4,517,751(+) ACAAA(A/C)AAAAA intron-variant

Variation tolerance for CDIP1 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDIP1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDIP1 Gene

Disorders for CDIP1 Gene

Relevant External Links for CDIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CDIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDIP1 Gene

Publications for CDIP1 Gene

  1. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. (PMID: 17599062) Brown L. … Lee S.W. (EMBO J. 2007) 2 3 4 67
  2. C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed in the brain. (PMID: 10570909) Bhalla K. … Callen D.F. (J. Hum. Genet. 1999) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3
  5. Expression of the p53 target CDIP correlates with sensitivity to TNFI+-induced apoptosis in cancer cells. (PMID: 22549949) Brown-Endres L. … Lee S.W. (Cancer Res. 2012) 3

Products for CDIP1 Gene

Sources for CDIP1 Gene