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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDIP1 Gene

protein-coding   GIFtS: 39
GCID: GC16M004560

Cell Death-Inducing P53 Target 1

(Previous name: chromosome 16 open reading frame 5)
(Previous symbol: C16orf5)
  Search for CDIP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Death-Inducing P53 Target 11 2     LITAFL2 3
C16orf51 2 3 5     LITAF-Like Protein2 3
Cell Death Involved P53-Target1 2 3     Chromosome 16 Open Reading Frame 51
Cell Death-Inducing Protein2 3     Lipopolysaccharide-Induced TNF Factor-Like1
Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha-Like Protein2 3     I12
Transmembrane Protein I12 3     Cell Death Inducing Protein2
CDIP2 3     Cell Death-Inducing P53-Target Protein 12

External Ids:    HGNC: 132341   Entrez Gene: 299652   Ensembl: ENSG000000894867   OMIM: 6105035   UniProtKB: Q9H3053   

Export aliases for CDIP1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CDIP1 Gene: 
CDIP1 (cell death-inducing p53 target 1) is a protein-coding gene. GO annotations related to this gene include molecular_function. An important paralog of this gene is LITAF.

UniProtKB/Swiss-Prot: CDIP1_HUMAN, Q9H305
Function: Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a
p53/TP53-dependent manner




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDIP1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CDIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

CDIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDIP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004560:  view genomic region     (about GC identifiers)

Start:
4,560,676 bp from pter      End:
4,588,829 bp from pter
Size:
28,154 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDIP1_HUMAN, Q9H305 (See protein sequence)
Recommended Name: Cell death-inducing p53-target protein 1  
Size: 208 amino acids; 21892 Da
Sequence caution: Sequence=AAF26619.1; Type=Frameshift; Positions=200;
Secondary accessions: A8K7M1 B4DFU1 B4DY75 D3DUD6 Q96ID8 Q9H0Q4 Q9P112
Alternative splicing: 3 isoforms:  Q9H305-1   Q9H305-2   Q9H305-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDIP1: NX_Q9H305

Explore proteomics data for CDIP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H305

  • CDIP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDIP1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001185983.1  NP_001185984.1  NP_001185985.1  NP_037531.2  

    ENSEMBL proteins: 
     ENSP00000454994   ENSP00000382508   ENSP00000457877   ENSP00000456461   ENSP00000455462  
     ENSP00000455050   ENSP00000466378   ENSP00000457255   ENSP00000466186   ENSP00000457370  
     ENSP00000465412   ENSP00000468627   ENSP00000467058  

    Human Recombinant Protein Products for CDIP1: 
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    Novus Biologicals CDIP1 Proteins
    Novus Biologicals CDIP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10570909

    CDIP1 for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006629 LITAF

    Graphical View of Domain Structure for InterPro Entry Q9H305

    ProtoNet protein and cluster: Q9H305

    UniProtKB/Swiss-Prot: CDIP1_HUMAN, Q9H305
    Similarity: Belongs to the CDIP1/LITAF family


    CDIP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDIP1_HUMAN, Q9H305
    Function: Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a
    p53/TP53-dependent manner
    Induction: Up-regulated by p53/TP53

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    CDIP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDIP1 
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    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDIP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDIP1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for CDIP1 (Q9H3053 ENSP000003825084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNIP1Q150253I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IGI17599062
    GO:0033209tumor necrosis factor-mediated signaling pathway IGI17599062
    GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP17599062

    CDIP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDIP1

    Search CenterWatch for drugs/clinical trials and news about CDIP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDIP1 gene (4 alternative transcripts): 
    NM_001199054.1  NM_001199055.1  NM_001199056.1  NM_013399.2  

    Unigene Cluster for CDIP1:

    Cell death-inducing p53 target 1
    Hs.654653  [show with all ESTs]
    Unigene Representative Sequence: AF131218
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000563332(uc002cwv.3 uc002cww.3 uc010uxl.2 uc010uxm.2 uc010btu.3)
    ENST00000399599(uc002cwu.3) ENST00000567695 ENST00000564828 ENST00000563507
    ENST00000562334 ENST00000589159 ENST00000562579 ENST00000589890 ENST00000563186
    ENST00000588381 ENST00000586728 ENST00000566234 ENST00000586768
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF131218.1 AF195661.1 AK292036.1 AK294257.1 AK302297.1 AK307067.1 AK308532.1 AK311295.1 
    AL136698.1 AL833853.1 BC002882.2 BC007604.1 CR533446.1 DQ167023.1 

    19 DOTS entries:

    DT.92437152  DT.92437147  DT.447203  DT.100789985  DT.95303265  DT.120676672  DT.120676718  DT.100789988 
    DT.99973947  DT.102833269  DT.120676678  DT.120676703  DT.91723414  DT.95212062  DT.120676610  DT.120676705 
    DT.75160544  DT.40116416  DT.92437150 

    24/271 AceView cDNA sequences (see all 271):

    BQ052917 BM971770 BX100026 CB155310 BQ771963 BQ001157 F10861 BM781973 
    BM722334 AW015231 AW027215 AI590525 T35911 BU838238 BQ054159 AI363035 
    BF740272 AA694126 AI272235 BQ021508 AA448130 BG819052 AW161049 BQ646454 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CDIP1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d
    SP1:                    -     -     -     -     -                                                                                 
    SP2:                    -     -     -     -     -                       -     -     -     -                                       
    SP3:                                -     -     -                                                                                 
    SP4:                                                                                                                              
    SP5:                    -     -     -     -     -                             -     -                                             


    ECgene alternative splicing isoforms for CDIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDIP1 expression in normal human tissues (normalized intensities)      CDIP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDIP1 Expression
    About this image


    CDIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Endothelium (Cardiovascular System)
             Peripheral blood-derived endothelial progenitor cells

    See CDIP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDIP1

    SOURCE GeneReport for Unigene cluster: Hs.654653

    UniProtKB/Swiss-Prot: CDIP1_HUMAN, Q9H305
    Tissue specificity: Highly expressed in brain. Expressed at lower level in heart, skeletal muscle, kidney,
    pancreas and liver. Weakly or not expressed in placenta and lung

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CDIP1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdip11 , 5 RIKEN cDNA 5730403B10 gene5
    cell death inducing Trp53 target 11
    88.14(n)1
    94.23(a)1
      16 (2.47 cM)5
    666261  NM_025670.41  NP_079946.21 
     47503485 
    chicken
    (Gallus gallus)
    Aves C14H16orf51 chromosome 14 open reading frame, human C16orf5 77.78(n)
    79.8(a)
      416662  XM_414959.3  XP_414959.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC527652 hypothetical protein MGC52765 78.5(n)    BC041237.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1656661 zgc:165666 65.85(n)
    67.98(a)
      557073  NM_001099242.1  NP_001092712.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG322801 CG32280 51.79(n)
    41.54(a)
      317952  NM_167992.1  NP_728818.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F36G3.36
    Protein F36G3.3
    27(a)
    1 ↔ 1
    X(9798835-9801038)


    ENSEMBL Gene Tree for CDIP1 (if available)
    TreeFam Gene Tree for CDIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDIP1 gene
    LITAF2  

    CDIP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/670 SNPs in CDIP1 are shown (see all 670)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47865061,2
    H--4560860(+) AGAGGT/GCGCCC 4 -- ut314Minor allele frequency- G:0.00NS EA 420
    rs1858796081,2
    --4560862(+) AGGTCA/GCCCAG 4 -- ut310--------
    rs77021,2
    C,F,A,H--4560929(+) TCTGTC/GTTGCT 4 -- ut3126Minor allele frequency- N:0.00MN NS EA NA WA CSA 1980
    rs178824321,2
    C,F,H--4561010(+) GATCCC/TATGCG 4 -- ut3115Minor allele frequency- T:0.02NS NA WA 1548
    rs1503858521,2
    C--4561103(+) CTGGCC/TCAGTC 4 -- ut310--------
    rs1899498981,2
    --4561126(+) CCCAGA/GGCTGG 4 -- ut310--------
    rs1825854861,2
    --4561131(+) GGCTGA/GTCTAC 4 -- ut310--------
    rs178848331,2
    C,F,H--4561300(+) GGAAGC/TCAGGC 4 -- ut319Minor allele frequency- T:0.02NS NA WA 1068
    rs178816261,2
    C,F--4561532(+) TTGTGG/CCTGCT 4 -- ut311Minor allele frequency- C:0.01NS 176
    rs14771241,2
    H--4561588(+) CAGGCA/TCAGCA 4 -- ut315Minor allele frequency- T:0.01MN NS EA 604

    HapMap Linkage Disequilibrium report for CDIP1 (4560676 - 4588829 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CDIP1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CDIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDIP1 for disorders           About MalaCards
    OMIM gene information: 610503    OMIM disorders: --


    CDIP1 for disorders           About GeneDecksing


    Export disorders for CDIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDIP1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with CDIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner. (PubMed id 17599062)1, 2, 3 Brown L.... Lee S.W. (2007)
    2. C16orf5, a novel proline-rich gene at 16p13.3, is highly expressed in the brain. (PubMed id 10570909)1, 2, 3 Bhalla K.... Callen D.F. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    5. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Expression of the p53 target CDIP correlates with sens itivity to TNFa-induced apoptosis in cancer cells. (PubMed id 22549949)1 Brown-Endres L....Lee S.W. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29965 HGNC: 13234 AceView: C16orf5 Ensembl:ENSG00000089486 euGenes: HUgn29965
    ECgene: CDIP1 H-InvDB: CDIP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDIP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDIP1 gene:
    Search GeneIP for patents involving CDIP1

    GeneCards and IP:
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