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Aliases for CDHR4 Gene

Aliases for CDHR4 Gene

  • Cadherin-Related Family Member 4 2 3
  • Cadherin-Like Protein 29 3 4
  • Cadherin-Like 29 2 3
  • CDH29 3 4
  • Cadherin-Like Protein UNQ9392/PRO34300 3
  • PRO34300 3
  • VLLR9392 3

External Ids for CDHR4 Gene

Previous Symbols for CDHR4 Gene

  • CDH29

Summaries for CDHR4 Gene

GeneCards Summary for CDHR4 Gene

CDHR4 (Cadherin-Related Family Member 4) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDHR3.

UniProtKB/Swiss-Prot for CDHR4 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDHR4 Gene

Genomics for CDHR4 Gene

Genomic Location for CDHR4 Gene

Start:
49,790,732 bp from pter
End:
49,799,835 bp from pter
Size:
9,104 bases
Orientation:
Minus strand

Genomic View for CDHR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDHR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDHR4 Gene

No data available for Regulatory Elements for CDHR4 Gene

Proteins for CDHR4 Gene

  • Protein details for CDHR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6H8M9-CDHR4_HUMAN
    Recommended name:
    Cadherin-related family member 4
    Protein Accession:
    A6H8M9
    Secondary Accessions:
    • Q6UXT0

    Protein attributes for CDHR4 Gene

    Size:
    788 amino acids
    Molecular mass:
    85827 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDHR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDHR4 Gene

Proteomics data for CDHR4 Gene at MOPED

Post-translational modifications for CDHR4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn242

Other Protein References for CDHR4 Gene

No data available for DME Specific Peptides for CDHR4 Gene

Domains for CDHR4 Gene

Gene Families for CDHR4 Gene

HGNC:
  • CDHR :Cadherins / Cadherin-related

Protein Domains for CDHR4 Gene

UniProtKB/Swiss-Prot:

CDHR4_HUMAN
Domain:
  • Contains 4 cadherin domains.:
    • A6H8M9
genes like me logo Genes that share domains with CDHR4: view

Function for CDHR4 Gene

Molecular function for CDHR4 Gene

UniProtKB/Swiss-Prot Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).

Gene Ontology (GO) - Molecular Function for CDHR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDHR4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDHR4 Gene

Localization for CDHR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDHR4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDHR4 Gene COMPARTMENTS Subcellular localization image for CDHR4 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CDHR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDHR4: view

Pathways for CDHR4 Gene

SuperPathways for CDHR4 Gene

No Data Available

Interacting Proteins for CDHR4 Gene

Gene Ontology (GO) - Biological Process for CDHR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with CDHR4: view

No data available for Pathways by source for CDHR4 Gene

Compounds for CDHR4 Gene

(1) HMDB Compounds for CDHR4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CDHR4: view

Transcripts for CDHR4 Gene

mRNA/cDNA for CDHR4 Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDHR4 Gene

Cadherin-related family member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDHR4 Gene

No ASD Table

Relevant External Links for CDHR4 Gene

GeneLoc Exon Structure for
CDHR4
ECgene alternative splicing isoforms for
CDHR4

Expression for CDHR4 Gene

mRNA expression in normal human tissues for CDHR4 Gene

mRNA differential expression in normal tissues according to GTEx for CDHR4 Gene

This gene is overexpressed in Fallopian Tube (15.7), Cervix - Endocervix (10.4), Testis (8.0), and Lung (5.5).

SOURCE GeneReport for Unigene cluster for CDHR4 Gene Hs.363312

genes like me logo Genes that share expressions with CDHR4: view

Orthologs for CDHR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDHR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDHR4 36
  • 98.88 (n)
  • 97.94 (a)
CDHR4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDHR4 36
  • 82.86 (n)
  • 76.04 (a)
CDHR4 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDHR4 36
  • 81.51 (n)
  • 74.62 (a)
CDHR4 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdhr4 36
  • 79.17 (n)
  • 72.68 (a)
Cdhr4 16
Cdhr4 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDHR4 37
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 37 (a)
OneToMany
-- 37
  • 42 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cdhr4 36
  • 79.3 (n)
  • 72.89 (a)
chicken
(Gallus gallus)
Aves CDHR4 36
  • 50.2 (n)
  • 37.28 (a)
CDHR4 37
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDHR4 37
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdhr4 36
  • 48.61 (n)
  • 39.87 (a)
Species with no ortholog for CDHR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDHR4 Gene

ENSEMBL:
Gene Tree for CDHR4 (if available)
TreeFam:
Gene Tree for CDHR4 (if available)

Paralogs for CDHR4 Gene

Paralogs for CDHR4 Gene

genes like me logo Genes that share paralogs with CDHR4: view

Variants for CDHR4 Gene

Sequence variations from dbSNP and Humsavar for CDHR4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6446296 -- 49,800,619(+) tatca(A/G)ttgga upstream-variant-2KB
rs6790568 -- 49,798,017(+) atgct(C/T)ctgcc intron-variant
rs6802890 -- 49,794,828(+) AACAC(A/G)GGTTG intron-variant
rs6804993 -- 49,800,603(+) tggtt(A/C)ccgtt upstream-variant-2KB
rs6809879 -- 49,797,138(+) TGCCT(A/G)CACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDHR4 Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV Loss 17160897
nsv876766 CNV Loss 21882294

Relevant External Links for CDHR4 Gene

HapMap Linkage Disequilibrium report
CDHR4

Disorders for CDHR4 Gene

Relevant External Links for CDHR4

Human Genome Epidemiology (HuGE) Navigator
CDHR4
genes like me logo Genes that share disorders with CDHR4: view

No data available for UniProtKB/Swiss-Prot for CDHR4 Gene

Publications for CDHR4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan A.R. … Ferguson L.R. (Hum. Immunol. 2010) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CDHR4 Gene

Sources for CDHR4 Gene

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