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Aliases for CDHR4 Gene

Aliases for CDHR4 Gene

  • Cadherin Related Family Member 4 2 3 5
  • Cadherin-Related Family Member 4 2 3
  • Cadherin-Like Protein 29 3 4
  • Cadherin-Like 29 2 3
  • CDH29 3 4
  • Cadherin-Like Protein UNQ9392/PRO34300 3
  • PRO34300 3
  • VLLR9392 3

External Ids for CDHR4 Gene

Previous HGNC Symbols for CDHR4 Gene

  • CDH29

Previous GeneCards Identifiers for CDHR4 Gene

  • GC03M049828

Summaries for CDHR4 Gene

GeneCards Summary for CDHR4 Gene

CDHR4 (Cadherin Related Family Member 4) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDHR3.

UniProtKB/Swiss-Prot for CDHR4 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDHR4 Gene

Genomics for CDHR4 Gene

Regulatory Elements for CDHR4 Gene

Enhancers for CDHR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F049802 0.6 ENCODE 35.4 -2.6 -2614 7.2 HDGF MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF263 CDHR4 FAM212A AMT WDR6 MIR5193
GH03F049812 0.4 ENCODE 34.6 -10.8 -10792 2.5 ELF3 IRF2 TFAP4 ZNF146 SAP130 ASH2L ARID4B ZBTB40 GATAD1 POLR2A CDHR4 MIR5193 UBA7
GH03F049784 1.1 ENCODE 31.7 +16.6 16605 3.2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 CDHR4 FAM212A AMT NICN1 QRICH1 ENSG00000225399 IMPDH2 C3orf18 IP6K1
GH03F049838 1 Ensembl ENCODE 29.8 -37.0 -37005 2.7 CTCF SAP130 ARID4B MAX ZIC2 RAD21 YY1 POLR2A ZNF143 SMC3 WDR6 CDHR4 FAM212A AMT GC03M049858 GC03M049859 UBA7
GH03F049855 0.6 ENCODE 27.8 -53.3 -53331 1.6 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 BRCA1 ETS1 CDHR4 QRICH1 NICN1 ENSG00000223343 ENSG00000225399 IMPDH2 GC03M049858 GC03M049859 UBA7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CDHR4 on UCSC Golden Path with GeneCards custom track

Promoters for CDHR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001363723 64 1801 ATF1 ZNF133 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 GATA2 ZNF143

Genomic Location for CDHR4 Gene

Chromosome:
3
Start:
49,790,732 bp from pter
End:
49,803,164 bp from pter
Size:
12,433 bases
Orientation:
Minus strand

Genomic View for CDHR4 Gene

Genes around CDHR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDHR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDHR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDHR4 Gene

Proteins for CDHR4 Gene

  • Protein details for CDHR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6H8M9-CDHR4_HUMAN
    Recommended name:
    Cadherin-related family member 4
    Protein Accession:
    A6H8M9
    Secondary Accessions:
    • Q6UXT0

    Protein attributes for CDHR4 Gene

    Size:
    788 amino acids
    Molecular mass:
    85827 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDHR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDHR4 Gene

Post-translational modifications for CDHR4 Gene

  • Glycosylation at Asn 242
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDHR4 Gene

Domains & Families for CDHR4 Gene

Gene Families for CDHR4 Gene

Protein Domains for CDHR4 Gene

Suggested Antigen Peptide Sequences for CDHR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6H8M9

UniProtKB/Swiss-Prot:

CDHR4_HUMAN :
  • Contains 4 cadherin domains.
Domain:
  • Contains 4 cadherin domains.
genes like me logo Genes that share domains with CDHR4: view

Function for CDHR4 Gene

Molecular function for CDHR4 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).

Gene Ontology (GO) - Molecular Function for CDHR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDHR4: view

Phenotypes for CDHR4 Gene

genes like me logo Genes that share phenotypes with CDHR4: view

Animal Model Products

miRNA for CDHR4 Gene

miRTarBase miRNAs that target CDHR4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDHR4 Gene

Localization for CDHR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDHR4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDHR4 Gene COMPARTMENTS Subcellular localization image for CDHR4 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CDHR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDHR4: view

Pathways & Interactions for CDHR4 Gene

SuperPathways for CDHR4 Gene

No Data Available

Interacting Proteins for CDHR4 Gene

Gene Ontology (GO) - Biological Process for CDHR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,IBA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007267 cell-cell signaling IBA --
GO:0007399 nervous system development IBA --
genes like me logo Genes that share ontologies with CDHR4: view

No data available for Pathways by source and SIGNOR curated interactions for CDHR4 Gene

Drugs & Compounds for CDHR4 Gene

(1) Drugs for CDHR4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDHR4: view

Transcripts for CDHR4 Gene

mRNA/cDNA for CDHR4 Gene

(9) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDHR4 Gene

Cadherin-related family member 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDHR4 Gene

No ASD Table

Relevant External Links for CDHR4 Gene

GeneLoc Exon Structure for
CDHR4
ECgene alternative splicing isoforms for
CDHR4

Expression for CDHR4 Gene

mRNA expression in normal human tissues for CDHR4 Gene

mRNA differential expression in normal tissues according to GTEx for CDHR4 Gene

This gene is overexpressed in Fallopian Tube (x15.7), Cervix - Endocervix (x10.4), Testis (x8.0), and Lung (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of CDHR4 Gene:

CDHR4

SOURCE GeneReport for Unigene cluster for CDHR4 Gene:

Hs.363312
genes like me logo Genes that share expression patterns with CDHR4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CDHR4 Gene

Orthologs for CDHR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDHR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDHR4 34 35
  • 98.88 (n)
cow
(Bos Taurus)
Mammalia CDHR4 34 35
  • 82.86 (n)
dog
(Canis familiaris)
Mammalia CDHR4 34 35
  • 81.51 (n)
rat
(Rattus norvegicus)
Mammalia Cdhr4 34
  • 79.3 (n)
mouse
(Mus musculus)
Mammalia Cdhr4 34 16 35
  • 79.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CDHR4 35
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDHR4 34 35
  • 50.2 (n)
lizard
(Anolis carolinensis)
Reptilia CDHR4 35
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdhr4 34
  • 48.61 (n)
Species where no ortholog for CDHR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDHR4 Gene

ENSEMBL:
Gene Tree for CDHR4 (if available)
TreeFam:
Gene Tree for CDHR4 (if available)

Paralogs for CDHR4 Gene

Paralogs for CDHR4 Gene

genes like me logo Genes that share paralogs with CDHR4: view

Variants for CDHR4 Gene

Sequence variations from dbSNP and Humsavar for CDHR4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs111479156 -- 49,803,281(+) TCGCG(C/T)AGGCA upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs112026700 -- 49,804,363(+) GACAG(A/G)GATGC upstream-variant-2KB, reference, synonymous-codon
rs112223079 -- 49,800,856(+) GCCTG(A/G)ACAAC intron-variant, upstream-variant-2KB
rs112233695 -- 49,797,638(+) CACCA(C/T)GCCTG intron-variant
rs113000938 -- 49,803,734(+) ACTAA(A/C)GAGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDHR4 Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV loss 17160897

Variation tolerance for CDHR4 Gene

Gene Damage Index Score: 3.26; 52.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDHR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDHR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDHR4 Gene

Disorders for CDHR4 Gene

Relevant External Links for CDHR4

Human Genome Epidemiology (HuGE) Navigator
CDHR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDHR4

No disorders were found for CDHR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDHR4 Gene

Publications for CDHR4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan A.R. … Ferguson L.R. (Hum. Immunol. 2010) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for CDHR4 Gene

Sources for CDHR4 Gene

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