CDHR4 Gene
protein-coding GIFtS: 38
GCID: GC03M049828
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cadherin-related family member 4(Previous name: cadherin-like 29 )
(Previous symbol: CDH29)
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Aliases
for CDHR4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cadherin-Related Family Member 41 2 | | Cadherin-Like Protein 292 3 | | CDH291 2 3 | | PRO343002 | | VLLR93921 2 | | Cadherin-Like Protein UNQ9392/PRO343002 | | Cadherin-Like 291 2 | | |
Export aliases for CDHR4 gene to outside databases |
Summaries
for CDHR4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CDHR4_HUMAN, A6H8M9Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in ahomophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (Bysimilarity)
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Genomic Views
for CDHR4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CDHR4
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDHR4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDHR4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31CDHR4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M049828: view genomic region
(about GC identifiers)
Start:
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49,828,165 bp from pter |
End:
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49,837,268 bp from pter |
Size:
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9,104 bases |
Orientation:
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minus strand |
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Proteins
for CDHR4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDHR4_HUMAN, A6H8M9 (See
protein sequence)Recommended Name: Cadherin-related family member 4 precursor Size: 788 amino acids; 85827 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: Q6UXT0Alternative splicing: 2 isoforms: A6H8M9-1 A6H8M9-2 Explore the universe of human proteins at neXtProt for CDHR4: NX_A6H8M9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6H8M9
CDHR4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001007541.2
ENSEMBL proteins: ENSP00000419433 ENSP00000417753 ENSP00000391409 ENSP00000341302 ENSP00000420677
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
CDHR4 for ontologies About GeneDecksing
CDHR4 Antibody Products:
Assay Products for CDHR4: |
Protein
Domains /
Families
for CDHR4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDHR4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6H8M9ProtoNet protein and cluster: A6H8M9 UniProtKB/Swiss-Prot: CDHR4_HUMAN, A6H8M9Similarity: Contains 4 cadherin domains |
Function
for CDHR4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CDHR4_HUMAN, A6H8M9Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in ahomophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDHR4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDHR4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CDHR4 (NM_001007540) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDHR4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDHR4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDHR4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- |
CDHR4 for ontologies About GeneDecksing
|
Pathways & Interactions
for CDHR4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDHR4
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007156 | homophilic cell adhesion |
IEA | -- |
CDHR4 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDHR4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDHR4
1 HMDB Compound for CDHR4 About this table
Search CenterWatch for drugs/clinical trials and news about CDHR4
|
Transcripts
for CDHR4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDHR4 gene: NM_001007540.2 Unigene Cluster for CDHR4: Cadherin-related family member 4 Hs.363312 [show with all ESTs]Unigene Representative Sequence: NM_0010075406 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000462108 ENST00000487666 ENST00000460430 ENST00000412678(uc010hkz.3)
ENST00000343366(uc003cxp.2) ENST00000487256(uc011bcw.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDHR4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDHR4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDHR4 (NM_001007540) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDHR4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDHR4 |
Additional cDNA sequence: AY358221.1 BC132756.1 BC144445.1 BC146674.1 3 DOTS entries: DT.75122800 DT.100653348 DT.120863012 4 AceView cDNA sequences: CF891017 AY358221 CB241135 CF887405
GeneLoc Exon Structure
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Expression
for CDHR4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDHR4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTGTATTT
About this image
See CDHR4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.363312
SABiosciences Custom PCR Arrays for CDHR4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDHR4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDHR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDHR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDHR4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDHR4 |
Orthologs
for CDHR4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CDHR4 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for CDHR4 (if available)
TreeFam Gene Tree for CDHR4 (if available) |
Paralogs
for CDHR4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDHR4 gene
- CDHR32
CDHR4 for paralogs About GeneDecksing
|
Genomic Variants
for CDHR4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDHR4 (49828165 - 49837268 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDHR4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDHR4 |
|
Disorders
/ Diseases
for CDHR4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CDHR4 for disorders About GeneDecksing
1  disease for CDHR4: About MalaCardscrohn's disease
Human Genome Epidemiology (HuGE) Navigator: CDHR4 (0 documents)
Export disorders for CDHR4 gene to outside databases
|
Publications
for CDHR4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDHR4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CDHR4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PubMed id 20307617)1 Morgan A.R....Ferguson L.R. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for CDHR4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDHR4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDHR4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDHR4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDHR4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CDHR4 gene:
Search GeneIP for patents involving CDHR4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDHR4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CDHR4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDHR4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDHR4 | | | OriGene Protein Over-expression Lysate for CDHR4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDHR4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDHR4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDHR4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CDHR4 | | OriGene Custom Protein Services for CDHR4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDHR4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDHR4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDHR4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDHR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDHR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDHR4 |
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 |  |  |  | |
| | | | Search Tocris compounds for CDHR4 |
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 | | | CDHR4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDHR4 |
|  |  |  | | | | Search ThermoFisher Antibodies for CDHR4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDHR4 |
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