CDHR3 Gene
protein-coding GIFtS: 43
GCID: GC07P105517
|
|
cadherin-related family member 3
| |
Aliases
for CDHR3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cadherin-Related Family Member 31 2 | | CDH281 2 3 | | Cadherin-Like Protein 282 3 | | FLJ238341 | | FLJ443661 |
Export aliases for CDHR3 gene to outside databasesPrevious GC identifer: GC07P099964 |
Summaries
for CDHR3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CDHR3_HUMAN, Q6ZTQ4Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in ahomophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types
|
Genomic Views
for CDHR3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CDHR3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CDHR3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDHR3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.3 Ensembl cytogenetic band: 7q22.3 HGNC cytogenetic band: 7q22.2CDHR3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P105517: view genomic region
(about GC identifiers)
Start:
|
105,517,242 bp from pter |
End:
|
105,676,877 bp from pter |
Size:
|
159,636 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 104,964,683-105,037,907 |
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Proteins
for CDHR3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CDHR3_HUMAN, Q6ZTQ4 (See
protein sequence)Recommended Name: Cadherin-related family member 3 precursor Size: 885 amino acids; 97977 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: Q8TCI7Alternative splicing: 2 isoforms: Q6ZTQ4-1 Q6ZTQ4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CDHR3: NX_Q6ZTQ4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZTQ4
CDHR3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689963.2
ENSEMBL proteins: ENSP00000419593 ENSP00000325954 ENSP00000417771 ENSP00000417198 ENSP00000419017 ENSP00000418958 ENSP00000439766 ENSP00000443733 ENSP00000341510
Human Recombinant Protein Products for CDHR3:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CDHR3 for ontologies About GeneDecksing
CDHR3 Antibody Products:
Assay Products for CDHR3: |
Protein
Domains /
Families
for CDHR3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CDHR3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZTQ4ProtoNet protein and cluster: Q6ZTQ4 1 Blocks protein family: IPB002126 Cadherin
UniProtKB/Swiss-Prot: CDHR3_HUMAN, Q6ZTQ4Similarity: Contains 6 cadherin domains |
Function
for CDHR3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CDHR3_HUMAN, Q6ZTQ4Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in ahomophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- |
CDHR3 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for CDHR3:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDHR3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDHR3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CDHR3 (NM_152750) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDHR3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDHR3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDHR3 |
|
Pathways & Interactions
for CDHR3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDHR3
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007156 | homophilic cell adhesion |
IEA | -- |
CDHR3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CDHR3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CDHR3
1 HMDB Compound for CDHR3 About this table
Search CenterWatch for drugs/clinical trials and news about CDHR3
|
Transcripts
for CDHR3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CDHR3 gene: NM_152750.4 Unigene Cluster for CDHR3: Cadherin-related family member 3 Hs.150120 [show with all ESTs]Unigene Representative Sequence: NM_15275017 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000487084 ENST00000474330 ENST00000470188 ENST00000488386 ENST00000472116
ENST00000317716 ENST00000478080 ENST00000461766 ENST00000496633 ENST00000466045
ENST00000471910 ENST00000466351 ENST00000468477 ENST00000468143 ENST00000542731(uc003vdl.4 uc003vdm.4 uc011klt.2)
ENST00000541203 ENST00000343407(uc003vdk.3 uc011kls.1 uc003vdn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDHR3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDHR3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CDHR3 (NM_152750) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDHR3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDHR3 |
Additional cDNA sequence: AK074414.1 AK125261.1 AK126338.1 AK131293.1 AK304118.1 AK304352.1 BC111696.1 BC111738.1 11 DOTS entries: DT.101957894 DT.75100706 DT.436794 DT.102829709 DT.100768339 DT.100751666 DT.107457 DT.121093143 DT.40127428 DT.100013068 DT.40190683 24/60 AceView cDNA sequences (see all 60): AI792798 AK125261 AA292873 CR604543 BP341691 BX115477 BI768220 Z41922 AA974855 BF195172 BQ668694 AI924018 Z38217 BQ670922 BQ669362 AI299366 AI272975 AI299610 BX482126 AI793167 CR607992 CB850790 BE857564 CN479975
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CDHR3 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CDHR3
|
Expression
for CDHR3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CDHR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAATGAAGT
About this image
See CDHR3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDHR3
SOURCE GeneReport for Unigene cluster: Hs.150120
SABiosciences Custom PCR Arrays for CDHR3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDHR3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDHR3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDHR3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDHR3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDHR3 |
Orthologs
for CDHR3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CDHR3 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for CDHR3 (if available)
TreeFam Gene Tree for CDHR3 (if available) |
Paralogs
for CDHR3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CDHR3 gene
- CDHR42
CDHR3 for paralogs About GeneDecksing
|
Genomic Variants
for CDHR3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CDHR3 (105517242 - 105676877 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CDHR3
1 CNV: 59373 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDHR3 |
|
Disorders
/ Diseases
for CDHR3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CDHR3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CDHR3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CDHR3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Genome-wide association study identifies genetic dete rminants of warfarin responsiveness for Japanese. (PubMed id 20833655)1 Cha P.C....Nakamura Y. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
|
External Searches for CDHR3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CDHR3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CDHR3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CDHR3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CDHR3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CDHR3 gene:
Search GeneIP for patents involving CDHR3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CDHR3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CDHR3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDHR3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDHR3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CDHR3 | | OriGene 3'-UTR Clone for CDHR3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDHR3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDHR3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CDHR3 | | OriGene Custom Protein Services for CDHR3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDHR3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDHR3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDHR3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDHR3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDHR3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDHR3 |
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 |  |  |  | |
| | | | Search Tocris compounds for CDHR3 |
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 | | | CDHR3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDHR3 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CDHR3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDHR3 |
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