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Aliases for CDHR3 Gene

Aliases for CDHR3 Gene

  • Cadherin Related Family Member 3 2 3 5
  • Cadherin-Like Protein 28 3 4
  • CDH28 3 4
  • Cadherin-Related Family Member 3 2

External Ids for CDHR3 Gene

Previous GeneCards Identifiers for CDHR3 Gene

  • GC07P105517
  • GC07P099964

Summaries for CDHR3 Gene

GeneCards Summary for CDHR3 Gene

CDHR3 (Cadherin Related Family Member 3) is a Protein Coding gene. Diseases associated with CDHR3 include asthma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDHR4.

UniProtKB/Swiss-Prot for CDHR3 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

  • (Microbial infection) Acts as a receptor for rhinovirus C.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDHR3 Gene

Genomics for CDHR3 Gene

Regulatory Elements for CDHR3 Gene

Promoters for CDHR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDHR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDHR3 Gene

Chromosome:
7
Start:
105,876,796 bp from pter
End:
106,036,431 bp from pter
Size:
159,636 bases
Orientation:
Plus strand

Genomic View for CDHR3 Gene

Genes around CDHR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDHR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDHR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDHR3 Gene

Proteins for CDHR3 Gene

  • Protein details for CDHR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTQ4-CDHR3_HUMAN
    Recommended name:
    Cadherin-related family member 3
    Protein Accession:
    Q6ZTQ4
    Secondary Accessions:
    • Q8TCI7

    Protein attributes for CDHR3 Gene

    Size:
    885 amino acids
    Molecular mass:
    97977 Da
    Quaternary structure:
    • (Microbial infection) Interacts with rhinovirus C capsid proteins.

    Alternative splice isoforms for CDHR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDHR3 Gene

Proteomics data for CDHR3 Gene at MOPED

Post-translational modifications for CDHR3 Gene

  • Glycosylation at Asn 186, Asn 257, and Asn 624
  • Modification sites at PhosphoSitePlus

Other Protein References for CDHR3 Gene

No data available for DME Specific Peptides for CDHR3 Gene

Domains & Families for CDHR3 Gene

Gene Families for CDHR3 Gene

Protein Domains for CDHR3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CDHR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZTQ4

UniProtKB/Swiss-Prot:

CDHR3_HUMAN :
  • Contains 6 cadherin domains.
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with CDHR3: view

Function for CDHR3 Gene

Molecular function for CDHR3 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for rhinovirus C.

Phenotypes for CDHR3 Gene

genes like me logo Genes that share phenotypes with CDHR3: view

Animal Model Products

miRNA for CDHR3 Gene

miRTarBase miRNAs that target CDHR3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDHR3 Gene

Localization for CDHR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDHR3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDHR3 Gene COMPARTMENTS Subcellular localization image for CDHR3 gene
Compartment Confidence
plasma membrane 5
nucleus 3
endoplasmic reticulum 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CDHR3 Gene

Pathways & Interactions for CDHR3 Gene

SuperPathways for CDHR3 Gene

No Data Available

Interacting Proteins for CDHR3 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000325954%0d%0a9606.ENSP00000344456%0d%0a9606.ENSP00000346155%0d%0a9606.ENSP00000362481%0d%0a9606.ENSP00000311113%0d%0a
Selected Interacting proteins: ENSP00000325954 for CDHR3 Gene via STRING

Gene Ontology (GO) - Biological Process for CDHR3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDHR3 Gene

Drugs & Compounds for CDHR3 Gene

(1) Drugs for CDHR3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDHR3: view

Transcripts for CDHR3 Gene

Unigene Clusters for CDHR3 Gene

Cadherin-related family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDHR3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for CDHR3 Gene

GeneLoc Exon Structure for
CDHR3
ECgene alternative splicing isoforms for
CDHR3

Expression for CDHR3 Gene

mRNA expression in normal human tissues for CDHR3 Gene

mRNA differential expression in normal tissues according to GTEx for CDHR3 Gene

This gene is overexpressed in Fallopian Tube (x5.7).

Protein differential expression in normal tissues from HIPED for CDHR3 Gene

This gene is overexpressed in Pancreatic juice (51.5) and Tonsil (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDHR3 Gene



SOURCE GeneReport for Unigene cluster for CDHR3 Gene Hs.150120

mRNA Expression by UniProt/SwissProt for CDHR3 Gene

Q6ZTQ4-CDHR3_HUMAN
Tissue specificity: Expressed in bronchial epithelium from adults and in fetal lung tissue.
genes like me logo Genes that share expression patterns with CDHR3: view

Protein tissue co-expression partners for CDHR3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CDHR3 Gene

Orthologs for CDHR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDHR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDHR3 35
  • 84.18 (n)
  • 79.66 (a)
CDHR3 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDHR3 35
  • 83.65 (n)
  • 78.19 (a)
CDHR3 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdhr3 35
  • 81.49 (n)
  • 76.18 (a)
Cdhr3 16
Cdhr3 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDHR3 35
  • 99.13 (n)
  • 98.76 (a)
CDHR3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC686932 35
  • 77.28 (n)
  • 73.04 (a)
oppossum
(Monodelphis domestica)
Mammalia CDHR3 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDHR3 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDHR3 35
  • 58.94 (n)
  • 47.06 (a)
CDHR3 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDHR3 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdhr3 35
  • 58.32 (n)
  • 52.83 (a)
Species with no ortholog for CDHR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDHR3 Gene

ENSEMBL:
Gene Tree for CDHR3 (if available)
TreeFam:
Gene Tree for CDHR3 (if available)

Paralogs for CDHR3 Gene

Paralogs for CDHR3 Gene

genes like me logo Genes that share paralogs with CDHR3: view

Variants for CDHR3 Gene

Sequence variations from dbSNP and Humsavar for CDHR3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs35008315 - 105,974,960(+) CACCT(A/G)TGATC intron-variant, nc-transcript-variant, reference, missense
rs34426483 - 105,974,980(+) CCCCA(C/G)ATAGT intron-variant, nc-transcript-variant, reference, missense
rs6967330 - 106,018,005(+) GGACT(A/G)TGAAA intron-variant, nc-transcript-variant, reference, missense
rs234 -- 105,920,689(-) CCCTT(C/T)ATTCA intron-variant
rs41261 -- 105,971,386(-) GGAAC(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDHR3 Gene

Variant ID Type Subtype PubMed ID
nsv5891 CNV Loss 18451855
nsv820197 CNV Loss 19587683
esv269437 CNV Insertion 20981092

Variation tolerance for CDHR3 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.63; 94.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDHR3 Gene

HapMap Linkage Disequilibrium report
CDHR3
Human Gene Mutation Database (HGMD)
CDHR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDHR3 Gene

Disorders for CDHR3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDHR3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search CDHR3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDHR3_HUMAN
  • Note=Asthma susceptibility may be associated with variations affecting the gene represented in this entry in early childhood asthma with severe exacerbations occurring between 2 and 6 years of age. {ECO:0000269 PubMed:24241537}.

Relevant External Links for CDHR3

Genetic Association Database (GAD)
CDHR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDHR3
genes like me logo Genes that share disorders with CDHR3: view

No data available for Genatlas for CDHR3 Gene

Publications for CDHR3 Gene

  1. Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication. (PMID: 25848009) Bochkov Y.A. … Gern J.E. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3 4 67
  2. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. (PMID: 24241537) BA … Bisgaard H. (Nat. Genet. 2014) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. (PMID: 20833655) Cha P.C. … Nakamura Y. (Hum. Mol. Genet. 2010) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for CDHR3 Gene

Sources for CDHR3 Gene

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