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Aliases for CDHR3 Gene

Aliases for CDHR3 Gene

  • Cadherin-Related Family Member 3 2 3
  • Cadherin-Like Protein 28 3 4
  • CDH28 3 4

External Ids for CDHR3 Gene

Previous GeneCards Identifiers for CDHR3 Gene

  • GC07P105517
  • GC07P099964

Summaries for CDHR3 Gene

GeneCards Summary for CDHR3 Gene

CDHR3 (Cadherin-Related Family Member 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDHR4.

UniProtKB/Swiss-Prot for CDHR3 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDHR3 Gene

Genomics for CDHR3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDHR3 Gene

Start:
105,876,796 bp from pter
End:
106,036,431 bp from pter
Size:
159,636 bases
Orientation:
Plus strand

Genomic View for CDHR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDHR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDHR3 Gene

No data available for Regulatory Elements for CDHR3 Gene

Proteins for CDHR3 Gene

  • Protein details for CDHR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTQ4-CDHR3_HUMAN
    Recommended name:
    Cadherin-related family member 3
    Protein Accession:
    Q6ZTQ4
    Secondary Accessions:
    • Q8TCI7

    Protein attributes for CDHR3 Gene

    Size:
    885 amino acids
    Molecular mass:
    97977 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDHR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDHR3 Gene

Proteomics data for CDHR3 Gene at MOPED

Post-translational modifications for CDHR3 Gene

  • Glycosylation at Asn186, Asn257, and Asn624
  • Modification sites at PhosphoSitePlus

Other Protein References for CDHR3 Gene

No data available for DME Specific Peptides for CDHR3 Gene

Domains for CDHR3 Gene

Gene Families for CDHR3 Gene

HGNC:
  • CDHR :Cadherins / Cadherin-related

Protein Domains for CDHR3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CDHR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZTQ4

UniProtKB/Swiss-Prot:

CDHR3_HUMAN :
  • Q6ZTQ4
Domain:
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with CDHR3: view

Function for CDHR3 Gene

Molecular function for CDHR3 Gene

UniProtKB/Swiss-Prot Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Ontology (GO) - Molecular Function for CDHR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDHR3: view

Phenotypes for CDHR3 Gene

genes like me logo Genes that share phenotypes with CDHR3: view

Animal Model Products

miRNA for CDHR3 Gene

miRTarBase miRNAs that target CDHR3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDHR3 Gene

Localization for CDHR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDHR3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDHR3 Gene COMPARTMENTS Subcellular localization image for CDHR3 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDHR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 24241537
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDHR3: view

Pathways for CDHR3 Gene

SuperPathways for CDHR3 Gene

No Data Available

Interacting Proteins for CDHR3 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000325954%0d%0a9606.ENSP00000346155%0d%0a9606.ENSP00000344456%0d%0a9606.ENSP00000311113%0d%0a9606.ENSP00000362481%0d%0a
Selected Interacting proteins: ENSP00000325954 for CDHR3 Gene via STRING

Gene Ontology (GO) - Biological Process for CDHR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with CDHR3: view

No data available for Pathways by source for CDHR3 Gene

Compounds for CDHR3 Gene

(1) HMDB Compounds for CDHR3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CDHR3: view

Transcripts for CDHR3 Gene

Unigene Clusters for CDHR3 Gene

Cadherin-related family member 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDHR3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CDHR3
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDHR3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for CDHR3 Gene

GeneLoc Exon Structure for
CDHR3
ECgene alternative splicing isoforms for
CDHR3

Expression for CDHR3 Gene

mRNA expression in normal human tissues for CDHR3 Gene

mRNA differential expression in normal tissues according to GTEx for CDHR3 Gene

This gene is overexpressed in Fallopian Tube (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDHR3 Gene

SOURCE GeneReport for Unigene cluster for CDHR3 Gene Hs.150120

mRNA Expression by UniProt/SwissProt for CDHR3 Gene

Q6ZTQ4-CDHR3_HUMAN
Tissue specificity: Expressed in bronchial epithelium from adults and in fetal lung tissue.
genes like me logo Genes that share expressions with CDHR3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CDHR3 Gene

Orthologs for CDHR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDHR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDHR3 35
  • 99.13 (n)
  • 98.76 (a)
CDHR3 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDHR3 35
  • 84.18 (n)
  • 79.66 (a)
CDHR3 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDHR3 35
  • 83.65 (n)
  • 78.19 (a)
CDHR3 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdhr3 35
  • 81.49 (n)
  • 76.18 (a)
Cdhr3 16
Cdhr3 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDHR3 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDHR3 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC686932 35
  • 77.28 (n)
  • 73.04 (a)
chicken
(Gallus gallus)
Aves CDHR3 35
  • 58.94 (n)
  • 47.06 (a)
CDHR3 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDHR3 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdhr3 35
  • 58.32 (n)
  • 52.83 (a)
Species with no ortholog for CDHR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDHR3 Gene

ENSEMBL:
Gene Tree for CDHR3 (if available)
TreeFam:
Gene Tree for CDHR3 (if available)

Paralogs for CDHR3 Gene

Paralogs for CDHR3 Gene

genes like me logo Genes that share paralogs with CDHR3: view

Variants for CDHR3 Gene

Sequence variations from dbSNP and Humsavar for CDHR3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs234 -- 105,920,689(-) CCCTT(C/T)ATTCA intron-variant
rs826 -- 105,920,697(-) TGGGT(C/T)AACCC intron-variant
rs2326 -- 105,911,944(+) GCAAA(C/G)GGCCT intron-variant
rs2327 -- 105,911,954(+) TAAAC(C/T)AGTGG intron-variant
rs3051 -- 105,970,588(-) AACAC(C/G)GCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDHR3 Gene

Variant ID Type Subtype PubMed ID
nsv5891 CNV Loss 18451855
nsv820197 CNV Loss 19587683
esv269437 CNV Insertion 20981092

Relevant External Links for CDHR3 Gene

HapMap Linkage Disequilibrium report
CDHR3
Human Gene Mutation Database (HGMD)
CDHR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDHR3 Gene

Disorders for CDHR3 Gene

UniProtKB/Swiss-Prot

CDHR3_HUMAN
  • Note=Asthma susceptibility may be associated with variations affecting the gene represented in this entry in early childhood asthma with severe exacerbations occurring between 2 and 6 years of age. {ECO:0000269 PubMed:24241537}.

Relevant External Links for CDHR3

Genetic Association Database (GAD)
CDHR3
genes like me logo Genes that share disorders with CDHR3: view

Publications for CDHR3 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. (PMID: 20833655) Cha P.C. … Nakamura Y. (Hum. Mol. Genet. 2010) 3 48
  4. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. (PMID: 24241537) BA … Bisgaard H. (Nat. Genet. 2014) 3 4
  5. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with BehAset's disease. (PMID: 20622878) Remmers E.F. … GA1l A. (Nat. Genet. 2010) 48

Products for CDHR3 Gene

Sources for CDHR3 Gene

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