Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CDHR2 Gene

protein-coding   GIFtS: 46
GCID: GC05P175976

Cadherin-Related Family Member 2

(Previous name: protocadherin 24)
(Previous symbol: PCDH24)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cadherin-Related Family Member 21 2     PCLKC2 3
PCDH241 2 3     protocadherin-242
Protocadherin 241 2     PC-LKC3
Protocadherin LKC1 3     Protocadherin-243

External Ids:    HGNC: 182311   Entrez Gene: 548252   Ensembl: ENSG000000742767   UniProtKB: Q9BYE93   

Export aliases for CDHR2 gene to outside databases

Previous GC identifer: GC05P170893


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CDHR2 Gene:
This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily.
The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent
cell-cell adhesion molecules. This protocadherin represents a new candidate for tumor suppression. Alternatively
spliced transcript variants that encode the same protein have been identified. (provided by RefSeq, Jan 2010)

GeneCards Summary for CDHR2 Gene:
CDHR2 (cadherin-related family member 2) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDHR1.

UniProtKB/Swiss-Prot: CDHR2_HUMAN, Q9BYE9
Function: Role in contact inhibition at the lateral surface of epithelial cells

Gene Wiki entry for CDHR2 (PCLKC) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CDHR2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDHR2 promoter sequence
   Search Chromatin IP Primers for CDHR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDHR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

CDHR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDHR2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P175976:  view genomic region     (about GC identifiers)

Start:
175,969,512 bp from pter      End:
176,022,975 bp from pter
Size:
53,464 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CDHR2_HUMAN, Q9BYE9 (See protein sequence)
Recommended Name: Cadherin-related family member 2 precursor  
Size: 1310 amino acids; 141543 Da
Subunit: Interacts with MAST2
Sequence caution: Sequence=BAA90962.1; Type=Erroneous initiation;
Secondary accessions: A6NC80 Q9NXP8

Explore the universe of human proteins at neXtProt for CDHR2: NX_Q9BYE9

Explore proteomics data for CDHR2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn29, Asn134, Asn182, Asn188, Asn195, Asn300, Asn355, Asn371, Asn401, Asn460,
                                 Asn565, Asn600, Asn616, Asn632, Asn680, Asn696, Asn701, Asn775, Asn821, Asn871 (see all 24)
  • Modification sites at PhosphoSitePlus

  • See CDHR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001165447.1  NP_060145.3  

    ENSEMBL proteins: 
     ENSP00000424565   ENSP00000426838   ENSP00000261944   ENSP00000421078  

    CDHR2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CDHR2
    OriGene Protein Over-expression Lysate for CDHR2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CDHR2
    GenScript Custom Purified and Recombinant Proteins Services for CDHR2
    Novus Biologicals CDHR2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CDHR2 

    CDHR2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CDHR2
    Novus Biologicals CDHR2 Antibodies
    Search for Antibodies for CDHR2 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for CDHR2
    Search LSBio for Antibodies for CDHR2

    CDHR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDHR2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDHR2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CDHR2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CDHR: Cadherins / Cadherin-related

    3 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q9BYE9

    ProtoNet protein and cluster: Q9BYE9

    1 Blocks protein domain: IPB002126 Cadherin

    UniProtKB/Swiss-Prot: CDHR2_HUMAN, Q9BYE9
    Similarity: Contains 9 cadherin domains


    Find genes that share domains with CDHR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDHR2_HUMAN, Q9BYE9
    Function: Role in contact inhibition at the lateral surface of epithelial cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI12117771
         
    Find genes that share ontologies with CDHR2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDHR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDHR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDHR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDHR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDHR2:
    hsa-mir-335-5p (MIRT018407)

    Block miRNA regulation of human, mouse, rat CDHR2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CDHR2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDHR2
    Predesigned siRNA for gene silencing in human, mouse, rat CDHR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDHR2

    Clone
    Products:
         
    OriGene clones in human, mouse for CDHR2 (see all 10)
    OriGene ORF clones in mouse, rat for CDHR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDHR2 (NM_017675)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDHR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDHR2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDHR2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CDHR2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDHR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CDHR2_HUMAN, Q9BYE9: Apical cell membrane; Single-pass type I membrane protein. Cell junction. Note=Present at
    the cell junctions and the apical surface of cells. Colocalizes with actin at the microvilli-like structures
    which protrude from the apical surface
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IDA12117771
    GO:0016324apical plasma membrane IEA--
    GO:0030054cell junction IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CDHR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDHR2
    Interactions:

        Search GeneGlobe Interaction Network for CDHR2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CDHR2 (Q9BYE91, 3 ENSP000002619444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAST2Q6P0Q81, 3, ENSP000003546714EBI-493793,EBI-493777 I2D: score=2 STRING: ENSP00000354671
    UBCENSP000003448184STRING: ENSP00000344818
    HDAC1ENSP000003626494STRING: ENSP00000362649
    SIRT1ENSP000002120154STRING: ENSP00000212015
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IDA12117771
    GO:0007156homophilic cell adhesion IEA--
    GO:0030308negative regulation of cell growth IDA12117771

    Find genes that share ontologies with CDHR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDHR2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CDHR2 gene (2 alternative transcripts): 
    NM_001171976.1  NM_017675.4  

    Unigene Cluster for CDHR2:

    Cadherin-related family member 2
    Hs.4205  [show with all ESTs]
    Unigene Representative Sequence: NM_001171976
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510636(uc021yie.1) ENST00000510124 ENST00000261944(uc003mem.2 uc003men.1)
    ENST00000506348 ENST00000513031 ENST00000508085 ENST00000416365
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDHR2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CDHR2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDHR2
    Predesigned siRNA for gene silencing in human, mouse, rat CDHR2
    Clone
    Products:
         
    OriGene clones in human, mouse for CDHR2 (see all 10)
    OriGene ORF clones in mouse, rat for CDHR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDHR2 (NM_017675)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDHR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDHR2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CDHR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDHR2
      QuantiTect SYBR Green Assays in human, mouse, rat CDHR2
      QuantiFast Probe-based Assays in human, mouse, rat CDHR2

    Additional mRNA sequence: 

    AB047004.1 AK000131.1 AK000390.1 AK128446.1 AK225217.1 AK315055.1 BC130282.1 

    7 DOTS entries:

    DT.100660670  DT.412159  DT.75168130  DT.120839721  DT.91821964  DT.95264870  DT.95264872 

    Selected AceView cDNA sequences (see all 32):

    BM986948 BM713261 BI829619 NM_017675 AI453192 BX478603 BP369836 AB047004 
    BI830857 AW752023 BX478954 AA334554 AK000390 AA130885 BE047157 AK000131 
    BI050441 AI962069 T04973 AA861433 AW084548 AI216901 BM676379 AA130780 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CDHR2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23a · 23b ^
    SP1:                                                                                                                    -     -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
    SP1:                                                
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for CDHR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CDHR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAACCTCC
    CDHR2 Expression
    About this image

    CDHR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDHR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.4205

    UniProtKB/Swiss-Prot: CDHR2_HUMAN, Q9BYE9
    Tissue specificity: Highly expressed in liver, kidney and colon. Moderately expressed in small intestine.
    Down-regulated in a number of liver and colon cancers

        Custom PCR Arrays for CDHR2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CDHR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDHR2
    QuantiTect SYBR Green Assays in human, mouse, rat CDHR2
    QuantiFast Probe-based Assays in human, mouse, rat CDHR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDHR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CDHR2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdhr21 , 5 cadherin-related family member 21, 5 77.45(n)1
    73.07(a)1
      13 (29.03 cM)5
    2686631  NM_001033364.31  NP_001028536.21 
     547014615 
    chicken
    (Gallus gallus)
    Aves CDHR21 cadherin-related family member 2 59(n)
    49.39(a)
      416223  XM_414546.4  XP_414546.4 
    lizard
    (Anolis carolinensis)
    Reptilia CDHR26
    cadherin-related family member 2
    45(a)
    1 ↔ 1
    GL343548.1(92987-148138)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdhr21 cadherin-related family member 2 52.14(n)
    45.74(a)
      100491782  XM_002936943.2  XP_002936989.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005367041 cadherin-related family member 2-like 47.89(n)
    39.17(a)
      100536704  XM_003199963.2  XP_003200011.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cad86C6
    Cad86C
    11(a)
    1 → many
    3R(6652801-6674752)


    ENSEMBL Gene Tree for CDHR2 (if available)
    TreeFam Gene Tree for CDHR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CDHR2 gene
    CDHR12  
    6 SIMAP similar genes for CDHR2 using alignment to 2 protein entries:     CDHR2_HUMAN (see all proteins):
    PCDH24    FAT3    ME5    ME1    ME2    ME4

    Find genes that share paralogs with CDHR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CDHR2 (see all 1691)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0541484
    An acute myeloid leukemia sample4--see VAR_0541482 P L mis40--------
    rs1132001171,2
    Cuntested1175995764(+) TTCTTC/TGCTGT 4 F syn11Minor allele frequency- T:0.50CSA 2
    rs1464059461,2
    --175967552(+) TTAGGA/GTTACC 1 -- us2k10--------
    rs1479473531,2
    --175967674(+) CCCAGC/GAATGG 1 -- us2k10--------
    rs29632931,2
    C,F--175967732(+) TGTCCC/TTGCCC 1 -- us2k111Minor allele frequency- T:0.44NA WA CSA EA 372
    rs1923153631,2
    --175967829(+) TTCACA/GCGTGG 1 -- us2k10--------
    rs1840970111,2
    C--175967937(+) TCTTCA/GAATCC 1 -- us2k10--------
    rs1138652901,2
    F--175968012(+) CTACTG/ATGCGA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1437375091,2
    --175968018(+) TGCGAA/GCCTTG 1 -- us2k10--------
    rs795334641,2
    C,F--175968032(+) TCCCCG/ATACCC 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for CDHR2 (175969512 - 176022975 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CDHR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2341441CNV Deletion18987734
    dgv1057e199CNV Deletion23128226
    esv1281149CNV Insertion17803354
    nsv471056CNV Loss18288195
    dgv6375n71CNV Loss21882294
    nsv883144CNV Loss21882294
    nsv527791CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDHR2
    DNA2.0 Custom Variant and Variant Library Synthesis for CDHR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CDHR2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with CDHR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation. (PubMed id 12117771)1, 2, 3 Okazaki N.... Koga H. (Carcinogenesis 2002)
    2. Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma. (PubMed id 15534908)1, 2, 9 Yang L.Y.... Huang G.W. (World J. Gastroenterol. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Recent progress in protocadherin research. (PubMed id 11082270)1, 3 Suzuki S.T. (Exp. Cell Res. 2000)
    5. PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling. (PubMed id 19383367)1, 9 Ose R....Koga H. (Mol Oncol 2009)
    6. Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions. (PubMed id 22628312)1 Behrendt M....Naim H.Y. (Biol. Chem. 2012)
    7. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    8. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    9. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. (PubMed id 18987736)2 Ley T.J.... Wilson R.K. (Nature 2008)
    10. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54825 HGNC: 18231 AceView: PC-LKC Ensembl:ENSG00000074276 euGenes: HUgn54825
    ECgene: CDHR2 H-InvDB: CDHR2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CDHR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CDHR2 gene:
    Search GeneIP for patents involving CDHR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CDHR2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CDHR2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CDHR2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDHR2   OriGene Purified Protein for CDHR2  
     OriGene ORF clones in mouse, rat for CDHR2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDHR2   OriGene Custom Protein Services for CDHR2  

     
     
     Block miRNA regulation of human, mouse, rat CDHR2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CDHR2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDHR2 Predesigned siRNA for gene silencing in human, mouse, rat CDHR2
     QuantiFast Probe-based Assays in human, mouse, rat CDHR2 QuantiTect SYBR Green Assays in human, mouse, rat CDHR2
     Custom PCR Arrays for CDHR2 Search Chromatin IP Primers for CDHR2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDHR2  Search GeneGlobe Interaction Network for CDHR2
     Search Regulatory tfbs for CDHR2
     GenScript Custom Purified and Recombinant Proteins Services for CDHR2 GenScript cDNA clones with any tag delivered in your preferred vector for CDHR2
     GenScript Custom Assay Services for CDHR2 GenScript Custom overexpressing Cell Line Services for CDHR2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CDHR2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CDHR2 antibodies
     CDHR2 proteins
     Search for Antibodies for CDHR2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CDHR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for CDHR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDHR2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CDHR2
     SwitchGear Promoter luciferase reporter plasmids for CDHR2
     Search ThermoFisher Antibodies for CDHR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDHR2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDHR2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDHR2
     Search LSBio for Antibodies for CDHR2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CDHR2
      Search eBioscience for proteins for CDHR2
      Search eBioscience for elisas for CDHR2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDHR2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4