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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDHR2 Gene

protein-coding   GIFtS: 45
GCID: GC05P175976

Cadherin-Related Family Member 2

(Previous name: protocadherin 24)
(Previous symbol: PCDH24)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cadherin-Related Family Member 21 2     PCLKC2 3
PCDH241 2 3     protocadherin-242
Protocadherin 241 2     PC-LKC3
Protocadherin LKC1 3     Protocadherin-243

External Ids:    HGNC: 182311   Entrez Gene: 548252   Ensembl: ENSG000000742767   UniProtKB: Q9BYE93   

Export aliases for CDHR2 gene to outside databases

Previous GC identifer: GC05P170893


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDHR2 Gene:
This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily.
The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent
cell-cell adhesion molecules. This protocadherin represents a new candidate for tumor suppression. Alternatively
spliced transcript variants that encode the same protein have been identified. (provided by RefSeq, Jan 2010)

GeneCards Summary for CDHR2 Gene: 
CDHR2 (cadherin-related family member 2) is a protein-coding gene. Diseases associated with CDHR2 include colon cancer, and hepatocellular carcinoma. GO annotations related to this gene include protein binding and calcium ion binding. An important paralog of this gene is DCHS1.

UniProtKB/Swiss-Prot: CDHR2_HUMAN, Q9BYE9
Function: Role in contact inhibition at the lateral surface of epithelial cells

Gene Wiki entry for CDHR2 (PCLKC) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CDHR2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDHR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDHR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDHR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.2

CDHR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDHR2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P175976:  view genomic region     (about GC identifiers)

Start:
175,969,512 bp from pter      End:
176,022,975 bp from pter
Size:
53,464 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDHR2_HUMAN, Q9BYE9 (See protein sequence)
Recommended Name: Cadherin-related family member 2 precursor  
Size: 1310 amino acids; 141543 Da
Subunit: Interacts with MAST2
Subcellular location: Apical cell membrane; Single-pass type I membrane protein. Cell junction. Note=Present at
the cell junctions and the apical surface of cells. Colocalizes with actin at the microvilli-like structures
which protrude from the apical surface
Sequence caution: Sequence=BAA90962.1; Type=Erroneous initiation;
Secondary accessions: A6NC80 Q9NXP8

Explore the universe of human proteins at neXtProt for CDHR2: NX_Q9BYE9

Explore proteomics data for CDHR2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BYE9

  • CDHR2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDHR2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001165447.1  NP_060145.3  

    ENSEMBL proteins: 
     ENSP00000424565   ENSP00000426838   ENSP00000261944   ENSP00000421078  

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IDA12117771
    GO:0016324apical plasma membrane IEA--
    GO:0030054cell junction IEA--

    CDHR2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CDHR: Cadherins / Cadherin-related

    3 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q9BYE9

    ProtoNet protein and cluster: Q9BYE9

    1 Blocks protein domain: IPB002126 Cadherin

    UniProtKB/Swiss-Prot: CDHR2_HUMAN, Q9BYE9
    Similarity: Contains 9 cadherin domains


    CDHR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDHR2_HUMAN, Q9BYE9
    Function: Role in contact inhibition at the lateral surface of epithelial cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI12117771
         
    CDHR2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDHR2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDHR2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CDHR2 (Q9BYE91, 3 ENSP000002619444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAST2Q6P0Q81, 3, ENSP000003546714EBI-493793,EBI-493777 I2D: score=2 STRING: ENSP00000354671
    UBCENSP000003448184STRING: ENSP00000344818
    HDAC1ENSP000003626494STRING: ENSP00000362649
    SIRT1ENSP000002120154STRING: ENSP00000212015
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IDA12117771
    GO:0007156homophilic cell adhesion IEA--
    GO:0030308negative regulation of cell growth IDA12117771

    CDHR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDHR2

    Search CenterWatch for drugs/clinical trials and news about CDHR2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDHR2 gene (2 alternative transcripts): 
    NM_001171976.1  NM_017675.4  

    Unigene Cluster for CDHR2:

    Cadherin-related family member 2
    Hs.4205  [show with all ESTs]
    Unigene Representative Sequence: NM_001171976
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510636(uc021yie.1) ENST00000510124 ENST00000261944(uc003mem.2 uc003men.1)
    ENST00000506348 ENST00000513031 ENST00000508085 ENST00000416365
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    Additional mRNA sequence: 

    AB047004.1 AK000131.1 AK000390.1 AK128446.1 AK225217.1 AK315055.1 BC130282.1 

    7 DOTS entries:

    DT.100660670  DT.412159  DT.75168130  DT.120839721  DT.91821964  DT.95264870  DT.95264872 

    24/32 AceView cDNA sequences (see all 32):

    BI829619 AI453192 NM_017675 BM713261 BM986948 BX478603 AW752023 BI830857 
    AB047004 AA130885 AA334554 AI962069 BI050441 AK000390 BP369836 BX478954 
    AK000131 BE047157 AI216901 AA861433 AA130780 AW084548 BM676379 T04973 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CDHR2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23a · 23b ^
    SP1:                                                                                                                    -     -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
    SP1:                                                
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for CDHR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDHR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAACCTCC
    CDHR2 Expression
    About this image


    See CDHR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDHR2

    SOURCE GeneReport for Unigene cluster: Hs.4205

    UniProtKB/Swiss-Prot: CDHR2_HUMAN, Q9BYE9
    Tissue specificity: Highly expressed in liver, kidney and colon. Moderately expressed in small intestine.
    Down-regulated in a number of liver and colon cancers

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CDHR2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdhr21 , 5 cadherin-related family member 21, 5 77.45(n)1
    73.07(a)1
      13 (29.03 cM)5
    2686631  NM_001033364.31  NP_001028536.21 
     547014615 
    chicken
    (Gallus gallus)
    Aves CDHR21 cadherin-related family member 2 58.75(n)
    48.78(a)
      416223  XM_414546.3  XP_414546.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDHR26
    cadherin-related family member 2
    47(a)
    1 ↔ 1
    GL343548.1(92987-148138)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005367041 uncharacterized LOC100536704 48.04(n)
    39.2(a)
      100536704  XM_003199963.1  XP_003200011.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cad88C6
    Cad87A6
    (see all 4)
    Cad87A
    (see all 4)
    19(a)
    18(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    3R(10460475-10467334)
    3R(7719234-7774851)
    worm
    (Caenorhabditis elegans)
    Secernentea hmr-16
    Cadherin-related hmr-1
    8(a)
    possible ortholog
    I(11075758-11134667)


    ENSEMBL Gene Tree for CDHR2 (if available)
    TreeFam Gene Tree for CDHR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDHR2 gene
    DCHS12  DCHS22  CELSR32  CELSR12  FAT22  CDHR12  PCDH152  FAT42  
    FAT32  CELSR22  FAT12  
    6 SIMAP similar genes for CDHR2 using alignment to 2 protein entries:     CDHR2_HUMAN (see all proteins):
    PCDH24    FAT3    ME5    ME1    ME2    ME4

    CDHR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1691 SNPs in CDHR2 are shown (see all 1691)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0541484
    An acute myeloid leukemia sample4--see VAR_0541482 P L mis40--------
    rs1132001171,2
    Cuntested1175995764(+) TTCTTC/TGCTGT 4 F syn11Minor allele frequency- T:0.50CSA 2
    rs1464059461,2
    --175967552(+) TTAGGA/GTTACC 1 -- us2k10--------
    rs1479473531,2
    --175967674(+) CCCAGC/GAATGG 1 -- us2k10--------
    rs29632931,2
    C,F--175967732(+) TGTCCC/TTGCCC 1 -- us2k111Minor allele frequency- T:0.44NA WA CSA EA 372
    rs1923153631,2
    --175967829(+) TTCACA/GCGTGG 1 -- us2k10--------
    rs1840970111,2
    C--175967937(+) TCTTCA/GAATCC 1 -- us2k10--------
    rs1138652901,2
    F--175968012(+) CTACTG/ATGCGA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1437375091,2
    --175968018(+) TGCGAA/GCCTTG 1 -- us2k10--------
    rs795334641,2
    C,F--175968032(+) TCCCCG/ATACCC 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for CDHR2 (175969512 - 176022975 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CDHR2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2341441CNV Deletion18987734
    dgv1057e199CNV Deletion23128226
    esv1281149CNV Insertion17803354
    nsv471056CNV Loss18288195
    dgv6375n71CNV Loss21882294
    nsv883144CNV Loss21882294
    nsv527791CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CDHR2:    About MalaCards
    colon cancer    hepatocellular carcinoma


    CDHR2 for disorders           About GeneDecksing


    Export disorders for CDHR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDHR2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with CDHR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation. (PubMed id 12117771)1, 2, 3 Okazaki N.... Koga H. (2002)
    2. Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma. (PubMed id 15534908)1, 2, 9 Yang L.Y.... Huang G.W. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Recent progress in protocadherin research. (PubMed id 11082270)1, 3 Suzuki S.T. (2000)
    5. PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling. (PubMed id 19383367)1, 9 Ose R....Koga H. (2009)
    6. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    7. Cadherin-related protein 24 induces morphological chan ges and partial cell polarization by facilitating direct cell-cell interactions. (PubMed id 22628312)1 Behrendt M....Naim H.Y. (2012)
    8. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    9. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. (PubMed id 18987736)2 Ley T.J.... Wilson R.K. (2008)
    10. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54825 HGNC: 18231 AceView: PC-LKC Ensembl:ENSG00000074276 euGenes: HUgn54825
    ECgene: CDHR2 H-InvDB: CDHR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDHR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDHR2 gene:
    Search GeneIP for patents involving CDHR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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