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Aliases for CDH9 Gene

Aliases for CDH9 Gene

  • Cadherin 9 2 3 5
  • Cadherin 9, Type 2 (T1-Cadherin) 2 3
  • T1-Cadherin 3
  • Cadherin-9 3

External Ids for CDH9 Gene

Previous GeneCards Identifiers for CDH9 Gene

  • GC05M026567
  • GC05M027314
  • GC05M026880
  • GC05M026926

Summaries for CDH9 Gene

Entrez Gene Summary for CDH9 Gene

  • This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH9 Gene

CDH9 (Cadherin 9) is a Protein Coding gene. Among its related pathways are WNT Signaling and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH6.

UniProtKB/Swiss-Prot for CDH9 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Wiki entry for CDH9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH9 Gene

Genomics for CDH9 Gene

Regulatory Elements for CDH9 Gene

Enhancers for CDH9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CDH9 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDH9 Gene

Chromosome:
5
Start:
26,880,600 bp from pter
End:
27,121,198 bp from pter
Size:
240,599 bases
Orientation:
Minus strand

Genomic View for CDH9 Gene

Genes around CDH9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH9 Gene

Proteins for CDH9 Gene

  • Protein details for CDH9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULB4-CADH9_HUMAN
    Recommended name:
    Cadherin-9
    Protein Accession:
    Q9ULB4
    Secondary Accessions:
    • Q3B7I5

    Protein attributes for CDH9 Gene

    Size:
    789 amino acids
    Molecular mass:
    88689 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDH9 Gene

Post-translational modifications for CDH9 Gene

  • Glycosylation at Asn 255, Asn 437, Asn 455, and Asn 536
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDH9 Gene

Domains & Families for CDH9 Gene

Gene Families for CDH9 Gene

Suggested Antigen Peptide Sequences for CDH9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULB4

UniProtKB/Swiss-Prot:

CADH9_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH9: view

Function for CDH9 Gene

Molecular function for CDH9 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Ontology (GO) - Molecular Function for CDH9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDH9: view
genes like me logo Genes that share phenotypes with CDH9: view

Animal Model Products

CRISPR Products

miRNA for CDH9 Gene

miRTarBase miRNAs that target CDH9

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDH9 Gene

Localization for CDH9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH9 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH9 Gene COMPARTMENTS Subcellular localization image for CDH9 gene
Compartment Confidence
plasma membrane 5
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDH9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH9: view

Pathways & Interactions for CDH9 Gene

genes like me logo Genes that share pathways with CDH9: view

Gene Ontology (GO) - Biological Process for CDH9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0016337 single organismal cell-cell adhesion NAS 10861224
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CDH9: view

No data available for SIGNOR curated interactions for CDH9 Gene

Drugs & Compounds for CDH9 Gene

(1) Drugs for CDH9 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH9: view

Transcripts for CDH9 Gene

mRNA/cDNA for CDH9 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDH9 Gene

Cadherin 9, type 2 (T1-cadherin):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2:

Relevant External Links for CDH9 Gene

GeneLoc Exon Structure for
CDH9
ECgene alternative splicing isoforms for
CDH9

Expression for CDH9 Gene

mRNA expression in normal human tissues for CDH9 Gene

mRNA differential expression in normal tissues according to GTEx for CDH9 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x8.3), Brain - Nucleus accumbens (basal ganglia) (x7.6), Brain - Cortex (x7.5), Brain - Frontal Cortex (BA9) (x7.2), Brain - Amygdala (x5.2), and Brain - Putamen (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for CDH9 Gene

This gene is overexpressed in Pancreatic juice (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH9 Gene



Protein tissue co-expression partners for CDH9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDH9 Gene:

CDH9

SOURCE GeneReport for Unigene cluster for CDH9 Gene:

Hs.272212
genes like me logo Genes that share expression patterns with CDH9: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CDH9 Gene

Orthologs for CDH9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDH9 34
  • 91.14 (n)
  • 94.84 (a)
CDH9 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH9 34
  • 91.85 (n)
  • 94.93 (a)
CDH9 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh9 34
  • 86.47 (n)
  • 91.22 (a)
Cdh9 16
Cdh9 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDH9 34
  • 99.7 (n)
  • 99.75 (a)
CDH9 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh9 34
  • 86.97 (n)
  • 92.13 (a)
oppossum
(Monodelphis domestica)
Mammalia CDH9 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH9 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH9 34
  • 79.26 (n)
  • 83.65 (a)
CDH9 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH9 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh9 34
  • 71.79 (n)
  • 72.05 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01067945.1 35
  • 65 (a)
ManyToMany
cdh10 35
  • 62 (a)
ManyToMany
cdh6 35
  • 61 (a)
ManyToMany
Species where no ortholog for CDH9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH9 Gene

ENSEMBL:
Gene Tree for CDH9 (if available)
TreeFam:
Gene Tree for CDH9 (if available)

Paralogs for CDH9 Gene

Paralogs for CDH9 Gene

(18) SIMAP similar genes for CDH9 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDH9: view

Variants for CDH9 Gene

Sequence variations from dbSNP and Humsavar for CDH9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2288467 - 26,988,317(+) GTATA(C/T)AATGG reference, missense
rs2288466 - 26,988,221(+) GACCC(A/G)CTATC reference, missense
rs1428647 -- 26,985,380(+) GTCAA(A/G)TTTAA intron-variant
rs1428648 -- 26,985,389(+) AAACA(A/G)CTTCT intron-variant
rs1428649 -- 26,985,486(+) ATTTT(G/T)CTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH9 Gene

Variant ID Type Subtype PubMed ID
dgv9699n54 CNV loss 21841781
esv1001329 CNV insertion 20482838
esv2759335 CNV loss 17122850
esv3380329 OTHER inversion 20981092
esv3604457 CNV gain 21293372
esv3604458 CNV gain 21293372
nsv1022430 CNV gain 25217958
nsv1110788 CNV insertion 24896259
nsv1120505 CNV tandem duplication 24896259
nsv1131880 CNV deletion 24896259
nsv462021 CNV gain 19166990
nsv462023 CNV loss 19166990
nsv462024 CNV loss 19166990
nsv597645 CNV gain 21841781
nsv597679 CNV loss 21841781

Variation tolerance for CDH9 Gene

Residual Variation Intolerance Score: 8.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.10; 92.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH9 Gene

Disorders for CDH9 Gene

Relevant External Links for CDH9

Genetic Association Database (GAD)
CDH9
Human Genome Epidemiology (HuGE) Navigator
CDH9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH9

No disorders were found for CDH9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDH9 Gene

Publications for CDH9 Gene

  1. Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. (PMID: 10861224) Shimoyama Y. … Natori M. (Biochem. J. 2000) 3 4 22 65
  2. Common genetic variants on 5p14.1 associate with autism spectrum disorders. (PMID: 19404256) Wang K. … Hakonarson H. (Nature 2009) 3 46 65
  3. Cadherin-9 is a novel cell surface marker for the heterogeneous pool of renal fibroblasts. (PMID: 17668045) Thedieck C. … Klein G. (PLoS ONE 2007) 3 22 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PMID: 2059658) Suzuki S. … Tanihara H. (Cell Regul. 1991) 2 3 65

Products for CDH9 Gene

Sources for CDH9 Gene

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