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Aliases for CDH8 Gene

Aliases for CDH8 Gene

  • Cadherin 8 2 3 5
  • Cadherin 8, Type 2 2 3
  • Cadherin-8 3
  • Nbla04261 3

External Ids for CDH8 Gene

Previous GeneCards Identifiers for CDH8 Gene

  • GC16M052117
  • GC16M061772
  • GC16M061421
  • GC16M061462
  • GC16M060244
  • GC16M047556

Summaries for CDH8 Gene

Entrez Gene Summary for CDH8 Gene

  • This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH8 Gene

CDH8 (Cadherin 8) is a Protein Coding gene. Diseases associated with CDH8 include Learning Disability and Autism Spectrum Disorder. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Cell junction organization. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH11.

UniProtKB/Swiss-Prot for CDH8 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Wiki entry for CDH8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH8 Gene

Genomics for CDH8 Gene

Regulatory Elements for CDH8 Gene

Enhancers for CDH8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F061742 0.3 FANTOM5 1.4 +294.0 294042 0.3 CDH8 GC16P061739 RN7SKP76
GH16F062035 0.5 ENCODE 0.8 +1.3 1314 0.1 RNF2 SUZ12 EZH2 CDH8 GC16M061981
GH16F062034 0.4 ENCODE 0.8 +2.0 2024 0.2 CTCF CDH8 GC16M061981
GH16F062036 0.4 ENCODE 0.8 +1.8 1774 0.3 CTCF BCL11A CDH8 GC16M061981
GH16F062038 0.4 ENCODE 0.8 +0.6 584 0.2 RNF2 EZH2 CDH8 GC16M061981
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDH8 on UCSC Golden Path with GeneCards custom track

Promoters for CDH8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001802007 1035 1600 CTCF RNF2 SUZ12 BCL11A MAFK EZH2

Genomic Location for CDH8 Gene

Chromosome:
16
Start:
61,647,242 bp from pter
End:
62,037,035 bp from pter
Size:
389,794 bases
Orientation:
Minus strand

Genomic View for CDH8 Gene

Genes around CDH8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH8 Gene

Proteins for CDH8 Gene

  • Protein details for CDH8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55286-CADH8_HUMAN
    Recommended name:
    Cadherin-8
    Protein Accession:
    P55286
    Secondary Accessions:
    • B3KWC1
    • Q14DC6
    • Q9ULB2

    Protein attributes for CDH8 Gene

    Size:
    799 amino acids
    Molecular mass:
    88253 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA35628.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CDH8 Gene

Post-translational modifications for CDH8 Gene

  • Glycosylation at Asn 33, Asn 57, Asn 188, Asn 463, Asn 473, and Asn 544
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDH8 Gene

Domains & Families for CDH8 Gene

Gene Families for CDH8 Gene

Suggested Antigen Peptide Sequences for CDH8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55286

UniProtKB/Swiss-Prot:

CADH8_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH8: view

Function for CDH8 Gene

Molecular function for CDH8 Gene

GENATLAS Biochemistry:
cadherin chicken cadherin 8,transmembrane glycoprotein component of adherens junction,expressed in brain,putatively involved in synaptic adhesion,axon outgrowth and guidance
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Ontology (GO) - Molecular Function for CDH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH8: view
genes like me logo Genes that share phenotypes with CDH8: view

Animal Models for CDH8 Gene

MGI Knock Outs for CDH8:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH8 Gene

Localization for CDH8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH8 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH8 gene
Compartment Confidence
plasma membrane 5
extracellular 3
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CDH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043083 synaptic cleft IEA --
GO:0043679 axon terminus IEA --
genes like me logo Genes that share ontologies with CDH8: view

Pathways & Interactions for CDH8 Gene

genes like me logo Genes that share pathways with CDH8: view

Gene Ontology (GO) - Biological Process for CDH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,TAS 2059658
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007268 chemical synaptic transmission IEA --
GO:0009409 response to cold IEA --
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CDH8: view

No data available for SIGNOR curated interactions for CDH8 Gene

Drugs & Compounds for CDH8 Gene

(1) Drugs for CDH8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH8: view

Transcripts for CDH8 Gene

Unigene Clusters for CDH8 Gene

Cadherin 8, type 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH8 Gene

No ASD Table

Relevant External Links for CDH8 Gene

GeneLoc Exon Structure for
CDH8
ECgene alternative splicing isoforms for
CDH8

Expression for CDH8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDH8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH8 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.5), Brain - Cortex (x5.4), Brain - Putamen (basal ganglia) (x5.3), Brain - Nucleus accumbens (basal ganglia) (x5.3), Brain - Caudate (basal ganglia) (x5.2), Brain - Anterior cingulate cortex (BA24) (x5.0), and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for CDH8 Gene

This gene is overexpressed in Testis (49.6) and Placenta (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH8 Gene



Protein tissue co-expression partners for CDH8 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDH8 Gene:

CDH8

SOURCE GeneReport for Unigene cluster for CDH8 Gene:

Hs.368322

mRNA Expression by UniProt/SwissProt for CDH8 Gene:

P55286-CADH8_HUMAN
Tissue specificity: Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.
genes like me logo Genes that share expression patterns with CDH8: view

Primer Products

Orthologs for CDH8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH8 34 35
  • 99.71 (n)
oppossum
(Monodelphis domestica)
Mammalia CDH8 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH8 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDH8 35
  • 92 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cdh8 34 16 35
  • 91.36 (n)
rat
(Rattus norvegicus)
Mammalia Cdh8 34
  • 91.2 (n)
dog
(Canis familiaris)
Mammalia CDH8 34 35
  • 85.77 (n)
chicken
(Gallus gallus)
Aves CDH8 34 35
  • 82.77 (n)
lizard
(Anolis carolinensis)
Reptilia CDH8 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh8 34
  • 77.81 (n)
zebrafish
(Danio rerio)
Actinopterygii CDH8 35
  • 78 (a)
OneToOne
cdh8 34
  • 69.25 (n)
Species where no ortholog for CDH8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH8 Gene

ENSEMBL:
Gene Tree for CDH8 (if available)
TreeFam:
Gene Tree for CDH8 (if available)

Paralogs for CDH8 Gene

Paralogs for CDH8 Gene

genes like me logo Genes that share paralogs with CDH8: view

Variants for CDH8 Gene

Sequence variations from dbSNP and Humsavar for CDH8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1012010 -- 61,978,686(+) ACTTG(C/G)GCAAG intron-variant
rs10153064 -- 61,693,197(+) AGTAT(A/T)TCCTT intron-variant
rs10153223 -- 62,014,335(+) AAGTC(A/G)GAACA intron-variant
rs10163452 -- 62,001,798(+) GTATA(A/T)CTCCT intron-variant
rs10163458 -- 62,001,984(+) AGTGA(A/G)TAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH8 Gene

Variant ID Type Subtype PubMed ID
dgv845e212 CNV loss 25503493
dgv846e212 CNV loss 25503493
esv1995444 CNV deletion 18987734
esv2353108 CNV deletion 18987734
esv2593208 CNV deletion 19546169
esv2658938 CNV deletion 23128226
esv2662954 CNV deletion 23128226
esv2665598 CNV deletion 23128226
esv2677187 CNV deletion 23128226
esv2714611 CNV deletion 23290073
esv2714612 CNV deletion 23290073
esv2714613 CNV deletion 23290073
esv2714614 CNV deletion 23290073
esv2760437 CNV loss 21179565
esv2762088 CNV gain+loss 21179565
esv3553541 CNV deletion 23714750
esv3553542 CNV deletion 23714750
esv3582265 CNV loss 25503493
esv3582270 CNV loss 25503493
esv3582271 CNV loss 25503493
esv3582273 CNV loss 25503493
esv3638782 CNV loss 21293372
esv3638783 CNV loss 21293372
esv3638784 CNV loss 21293372
esv3638785 CNV loss 21293372
esv3638786 CNV loss 21293372
esv3638787 CNV loss 21293372
esv3638788 CNV loss 21293372
esv5221 CNV loss 18987735
esv6216 CNV loss 19470904
nsv103700 CNV deletion 16902084
nsv1070352 CNV deletion 25765185
nsv1109016 CNV deletion 24896259
nsv1110288 CNV duplication 24896259
nsv1129580 CNV tandem duplication 24896259
nsv1132873 CNV insertion 24896259
nsv1134557 CNV deletion 24896259
nsv1138459 CNV deletion 24896259
nsv1142879 CNV tandem duplication 24896259
nsv1148262 CNV insertion 26484159
nsv1148368 CNV duplication 26484159
nsv1149563 CNV insertion 26484159
nsv457500 CNV loss 19166990
nsv474579 CNV novel sequence insertion 20440878
nsv475993 CNV novel sequence insertion 20440878
nsv507822 OTHER sequence alteration 20534489
nsv572844 CNV loss 21841781
nsv572845 CNV loss 21841781
nsv572846 CNV loss 21841781
nsv817733 CNV gain 17921354
nsv827699 CNV loss 20364138
nsv827700 CNV loss 20364138
nsv833256 CNV gain 17160897
nsv958829 CNV deletion 24416366

Variation tolerance for CDH8 Gene

Residual Variation Intolerance Score: 5.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH8 Gene

Human Gene Mutation Database (HGMD)
CDH8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH8 Gene

Disorders for CDH8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDH8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
learning disability
  • academic skill disorder
autism spectrum disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards
Search CDH8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDH8

Genetic Association Database (GAD)
CDH8
Human Genome Epidemiology (HuGE) Navigator
CDH8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH8
genes like me logo Genes that share disorders with CDH8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH8 Gene

Publications for CDH8 Gene

  1. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PMID: 2059658) Suzuki S. … Tanihara H. (Cell Regul. 1991) 2 3 4 64
  2. Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. (PMID: 21602797) Wright F.A. … Cutting G.R. (Nat. Genet. 2011) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CDH8 Gene

Sources for CDH8 Gene

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