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CDH8 Gene

protein-coding   GIFtS: 61
GCID: GC16M061681

Cadherin 8, Type 2

  See CDH8-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cadherin 8, Type 21 2
Nbla042612
cadherin-82

External Ids:    HGNC: 17671   Entrez Gene: 10062   Ensembl: ENSG000001503947   OMIM: 6030085   UniProtKB: P552863   

Export aliases for CDH8 gene to outside databases

Previous GC identifers: GC16M052117 GC16M061772 GC16M061421 GC16M061462 GC16M060244 GC16M047556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDH8 Gene:
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that
mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal
extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic
domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to
determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are
defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This
particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and
guidance. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDH8 Gene:
CDH8 (cadherin 8, type 2) is a protein-coding gene. Diseases associated with CDH8 include learning disability. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH18.

UniProtKB/Swiss-Prot: CADH8_HUMAN, P55286
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Wiki entry for CDH8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDH8 gene promoter:
         Sox5   POU3F1   HNF-3beta   NF-kappaB   Tal-1beta   NF-AT   C/EBPalpha   E47   S8   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDH8 promoter sequence
   Search Chromatin IP Primers for CDH8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDH8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q22.1

CDH8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH8 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M061681:  view genomic region     (about GC identifiers)

Start:
61,681,146 bp from pter      End:
62,070,939 bp from pter
Size:
389,794 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CADH8_HUMAN, P55286 (See protein sequence)
Recommended Name: Cadherin-8 precursor  
Size: 799 amino acids; 88253 Da
Sequence caution: Sequence=AAA35628.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KWC1 Q14DC6 Q9ULB2

Explore the universe of human proteins at neXtProt for CDH8: NX_P55286

Explore proteomics data for CDH8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn33, Asn57, Asn188, Asn463, Asn473, Asn544
  • Modification sites at PhosphoSitePlus

  • See CDH8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001787.2  
    ENSEMBL proteins: 
     ENSP00000462018   ENSP00000463266   ENSP00000462701   ENSP00000299345   ENSP00000463511  
     ENSP00000462976   ENSP00000462847  
    Reactome Protein details: P55286

    CDH8 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CDH8
    Sino Biological Cell Lysate for CDH8
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    Cloud-Clone Corp. Proteins for CDH8

     
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    Search eBioscience for ELISAs for CDH8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MCDH: Cadherins / Major cadherins

    5 InterPro protein domains:
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR027397 Catenin_binding_dom
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry P55286

    ProtoNet protein and cluster: P55286

    2 Blocks protein domains:
    IPB000233 Cadherin cytoplasmic region
    IPB002126 Cadherin


    UniProtKB/Swiss-Prot: CADH8_HUMAN, P55286
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the
    connections, imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 5 cadherin domains


    Find genes that share domains with CDH8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CADH8_HUMAN, P55286
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
    a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

         Genatlas biochemistry entry for CDH8:
    cadherin chicken cadherin 8,transmembrane glycoprotein component of adherens junction,expressed in
    brain,putatively involved in synaptic adhesion,axon outgrowth and guidance

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with CDH8           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdh8):
     behavior/neurological  integument  nervous system 

    Find genes that share phenotypes with CDH8           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDH8
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    miRNA
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    Block miRNA regulation of human, mouse, rat CDH8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDH8 (see all 40):
    hsa-miR-21* hsa-miR-4291 hsa-miR-218-1* hsa-miR-485-3p hsa-miR-4305 hsa-miR-218 hsa-miR-4314 hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidCDH8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDH8
    Predesigned siRNA for gene silencing in human, mouse, rat CDH8

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CDH8 (NM_001796)
    Sino Biological Human cDNA Clone for CDH8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDH8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH8

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CADH8_HUMAN, P55286: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0043083synaptic cleft IEA--
    GO:0043679axon terminus IEA--

    Find genes that share ontologies with CDH8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDH8 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Adherens junctions interactions0.49
    2ERK Signaling
    Rho Family GTPases0.61
    ILK Signaling0.49
    3Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    4WNT Signaling
    WNT Signaling
    5S-1P Stimulated Signaling
    S-1P Stimulated Signaling


    Find genes that share SuperPaths with CDH8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDH8 (see all 7)
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    Presenilin-Mediated Signaling


    1 Reactome Pathway for CDH8
        Adherens junctions interactions


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDH8: 
              Parkinson's Disease in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDH8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for CDH8 (P552863 ENSP000002993454) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1P352223, ENSP000003444564I2D: score=2 STRING: ENSP00000344456
    CDH10ENSP000002644634STRING: ENSP00000264463
    CDH11ENSP000002686034STRING: ENSP00000268603
    CDH13ENSP000002686134STRING: ENSP00000268613
    CDH15ENSP000002897464STRING: ENSP00000289746
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS2059658
    GO:0007156homophilic cell adhesion IEA--
    GO:0007268synaptic transmission ----
    GO:0009409response to cold IEA--
    GO:0034329cell junction assembly TAS--

    Find genes that share ontologies with CDH8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDH8 (CADH8)

    1 HMDB Compound for CDH8    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDH8 gene: 
    NM_001796.4  

    Unigene Cluster for CDH8:

    Cadherin 8, type 2
    Hs.368322  [show with all ESTs]
    Unigene Representative Sequence: NM_001796
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577730 ENST00000585315 ENST00000577390(uc002eog.2) ENST00000299345
    ENST00000583483 ENST00000580044 ENST00000577536 ENST00000584337(uc002eoh.3)
    ENST00000582242 ENST00000583382 ENST00000584966 ENST00000577228 ENST00000584506
    ENST00000582980
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDH8 (see all 40):
    hsa-miR-21* hsa-miR-4291 hsa-miR-218-1* hsa-miR-485-3p hsa-miR-4305 hsa-miR-218 hsa-miR-4314 hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidCDH8 3' UTR sequence
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CDH8
      QuantiFast Probe-based Assays in human, mouse, rat CDH8

    Additional mRNA sequence: 

    AB035305.1 AB074170.1 AF451288.2 AK124734.1 BC113416.1 L34060.1 

    7 DOTS entries:

    DT.112641  DT.105298  DT.91713339  DT.120703995  DT.70103337  DT.100706612  DT.120680661 

    Selected AceView cDNA sequences (see all 51):

    AK124734 T65274 BG211576 AI650367 F07087 F03359 NM_001796 Z38479 
    BG192945 AB035305 F12091 AI825334 F09728 AI374911 AI968400 BX477733 
    BG216038 BG209998 BV204172 Z40176 F11916 F07086 AA552988 L34060 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDH8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTATTAG
    CDH8 Expression
    About this image


    CDH8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    CDH8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDH8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368322

    UniProtKB/Swiss-Prot: CADH8_HUMAN, P55286
    Tissue specificity: Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma
    cells and neuroblasts

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDH8: 
              Parkinson's Disease in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
    Products:
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDH8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDH8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdh81 , 5 cadherin 81, 5 91.36(n)1
    97(a)1
      8 (49.40 cM)5
    125641  NM_007667.31  NP_031693.21 
     990244715 
    chicken
    (Gallus gallus)
    Aves CDH81 cadherin 8, type 2 82.77(n)
    90.74(a)
      427553  NM_001100289.1  NP_001093759.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDH86
    cadherin 8, type 2
    82(a)
    1 ↔ 1
    LGc(7140565-7440704)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdh81 cadherin 8, type 2 77.81(n)
    85.48(a)
      100486228  XM_002935052.2  XP_002935098.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cdh81 cadherin 8, type 2 69.25(n)
    77.78(a)
      564205  XM_001919130.4  XP_001919165.3 


    ENSEMBL Gene Tree for CDH8 (if available)
    TreeFam Gene Tree for CDH8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDH8 gene
    CDH182  CDH222  CDH192  CDH102  CDH112  CDH72  CDH92  CDH62  
    CDH122  CDH242  CDH202  CDH52  
    Selected SIMAP similar genes for CDH8 using alignment to 8 protein entries:     CADH8_HUMAN (see all proteins) (see all similar genes):
    Nbla04261    CDH11    CDH7    CDH24    CDH9    CDH18
    CDH20    CDH6    CDH10    CDH22    CDH12    CDH19
    CDH17    FAT3    CDH2    CDH5    CDH4    CDH15

    Find genes that share paralogs with CDH8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDH8 (see all 7148)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172911831,2
    F--61685431(+) AAACCG/TTTCTC 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1511965621,2
    C--61685608(+) TTGTTA/GCAAGT 1 -- int10--------
    rs1403476551,2
    C--61685643(+) GGTTTC/TCCCTG 1 -- int10--------
    rs592871971,2
    C,F--61685653(+) GCCCAA/GTGCGT 1 -- int13Minor allele frequency- G:0.24WA CSA 122
    rs771222841,2
    C,F--61685698(+) CTAGCC/GTTTAG 1 -- int12Minor allele frequency- G:0.03NA EA 240
    rs1451268711,2
    C--61685735(+) GCTGGC/TATCTT 1 -- int10--------
    rs620453311,2
    C--61685782(+) TTTCTC/TTATAA 1 -- int13Minor allele frequency- T:0.16NA WA 240
    rs620453321,2
    C--61685786(+) TCTATA/GATAAA 1 -- int13Minor allele frequency- G:0.14NA WA 240
    rs1824044871,2
    --61685869(+) TTCTGC/TTAATA 1 -- int10--------
    rs1874153711,2
    --61685942(+) CAAAGC/TAGGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CDH8 (61681146 - 61931146 bp, first 250kb of CDH8)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CDH8 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662954CNV Deletion23128226
    esv5221CNV Deletion18987735
    esv1995444CNV Deletion18987734
    esv2677187CNV Deletion23128226
    esv2665598CNV Deletion23128226
    esv2714613CNV Deletion23290073
    esv2658938CNV Deletion23128226
    esv2714612CNV Deletion23290073
    esv2353108CNV Deletion18987734
    esv2714611CNV Deletion23290073

    Human Gene Mutation Database (HGMD): CDH8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDH8
    DNA2.0 Custom Variant and Variant Library Synthesis for CDH8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603008    OMIM disorders: --

    1 disease for CDH8:    
    About MalaCards
    learning disability

    1 disease from the University of Copenhagen DISEASES database for CDH8:
    Autistic disorder

    Find genes that share disorders with CDH8           About GenesLikeMe

    Genetic Association Database (GAD): CDH8
    Human Genome Epidemiology (HuGE) Navigator: CDH8 (1 document)

    Export disorders for CDH8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDH8 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with CDH8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PubMed id 2059658)1, 2, 3 Suzuki S.... Tanihara H. (Cell Regul. 1991)
    2. Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. (PubMed id 21602797)1, 4 Wright F.A....Cutting G.R. (Nat. Genet. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. (PubMed id 10861224)1, 2 Shimoyama Y.... Natori M. (Biochem. J. 2000)
    7. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. (PubMed id 9615235)1, 3 Kremmidiotis G....Callen D.F. (Genomics 1998)
    8. Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. (PubMed id 7982033)1, 2 Tanihara H.... Suzuki S. (Cell Adhes. Commun. 1994)
    9. Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. (PubMed id 23144319)1 Lee Y....Lee J.S. (Carcinogenesis 2013)
    10. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1 Demirkan A....Schmitz G. (PLoS Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1006 HGNC: 1767 AceView: CDH8 Ensembl:ENSG00000150394 euGenes: HUgn1006
    ECgene: CDH8 H-InvDB: CDH8

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDH8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDH8 gene:
    Search GeneIP for patents involving CDH8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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