External Ids for CDH7 Gene
Previous GeneCards Identifiers for CDH7 Gene
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in this gene may be associated with bipolar disease in human patients. This gene is present in a gene cluster on chromosome 18. [provided by RefSeq, May 2016]
GeneCards Summary for CDH7 Gene
CDH7 (Cadherin 7) is a Protein Coding gene. Among its related pathways are Cell junction organization and G12-G13 in Cellular Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH10.
UniProtKB/Swiss-Prot for CDH7 Gene
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.