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Aliases for CDH7 Gene

Aliases for CDH7 Gene

  • Cadherin 7, Type 2 2 3
  • CDH7L1 3 4

External Ids for CDH7 Gene

Previous GeneCards Identifiers for CDH7 Gene

  • GC18P063262
  • GC18P063390
  • GC18P061566
  • GC18P061568
  • GC18P060120

Summaries for CDH7 Gene

Entrez Gene Summary for CDH7 Gene

  • This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in this gene may be associated with multiple psychiatric disorders and play a causal role in CHARGE syndrome in human patients. This gene is present in a gene cluster on chromosome 18. [provided by RefSeq, Nov 2015]

GeneCards Summary for CDH7 Gene

CDH7 (Cadherin 7, Type 2) is a Protein Coding gene. Diseases associated with CDH7 include charge syndrome. Among its related pathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH19.

UniProtKB/Swiss-Prot for CDH7 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH7 Gene

Genomics for CDH7 Gene

Regulatory Elements for CDH7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDH7 Gene

Chromosome:
18
Start:
65,750,252 bp from pter
End:
65,890,341 bp from pter
Size:
140,090 bases
Orientation:
Plus strand

Genomic View for CDH7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH7 Gene

Proteins for CDH7 Gene

  • Protein details for CDH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULB5-CADH7_HUMAN
    Recommended name:
    Cadherin-7
    Protein Accession:
    Q9ULB5
    Secondary Accessions:
    • Q9H157

    Protein attributes for CDH7 Gene

    Size:
    785 amino acids
    Molecular mass:
    87086 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDH7 Gene

Proteomics data for CDH7 Gene at MOPED

Post-translational modifications for CDH7 Gene

  • Glycosylation at Asn 449 and Asn 530
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH7 Gene

Antibody Products

No data available for DME Specific Peptides for CDH7 Gene

Domains & Families for CDH7 Gene

Gene Families for CDH7 Gene

Suggested Antigen Peptide Sequences for CDH7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULB5

UniProtKB/Swiss-Prot:

CADH7_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH7: view

Function for CDH7 Gene

Molecular function for CDH7 Gene

GENATLAS Biochemistry:
BH-cadherin chicken cadherin 7-like,transmembrane glycoprotein component of adherens junction,with two alternatively spliced isoforms,the major transcript predominantly expressed in the brain,putatively involved in synaptic adhesion,axon outgrowth and guidance,heart,the minor expressed in several cancer lines
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Ontology (GO) - Molecular Function for CDH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDH7: view

Animal Model Products

miRNA for CDH7 Gene

miRTarBase miRNAs that target CDH7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDH7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for CDH7 Gene

Localization for CDH7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH7 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH7 Gene COMPARTMENTS Subcellular localization image for CDH7 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for CDH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH7: view

Pathways & Interactions for CDH7 Gene

genes like me logo Genes that share pathways with CDH7: view

Gene Ontology (GO) - Biological Process for CDH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0016337 single organismal cell-cell adhesion NAS 10861224
GO:0034329 cell junction assembly TAS --
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CDH7: view

No data available for SIGNOR curated interactions for CDH7 Gene

Drugs & Compounds for CDH7 Gene

(1) Drugs for CDH7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with CDH7: view

Transcripts for CDH7 Gene

mRNA/cDNA for CDH7 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDH7 Gene

Cadherin 7, type 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDH7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH7 Gene

No ASD Table

Relevant External Links for CDH7 Gene

GeneLoc Exon Structure for
CDH7
ECgene alternative splicing isoforms for
CDH7

Expression for CDH7 Gene

mRNA expression in normal human tissues for CDH7 Gene

mRNA differential expression in normal tissues according to GTEx for CDH7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.2), Brain - Cerebellum (x8.9), and Nerve - Tibial (x6.9).

Protein differential expression in normal tissues from HIPED for CDH7 Gene

This gene is overexpressed in Plasma (55.2) and Heart (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH7 Gene



SOURCE GeneReport for Unigene cluster for CDH7 Gene Hs.657522

genes like me logo Genes that share expression patterns with CDH7: view

Protein tissue co-expression partners for CDH7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CDH7 Gene

Orthologs for CDH7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDH7 35
  • 89.6 (n)
  • 98.09 (a)
CDH7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH7 35
  • 91.85 (n)
  • 99.24 (a)
CDH7 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh7 35
  • 88.83 (n)
  • 97.96 (a)
Cdh7 16
Cdh7 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDH7 35
  • 99.62 (n)
  • 100 (a)
CDH7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh7 35
  • 88.11 (n)
  • 96.05 (a)
oppossum
(Monodelphis domestica)
Mammalia CDH7 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH7 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH7 35
  • 83.44 (n)
  • 93.5 (a)
CDH7 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH7 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh7 35
  • 76.46 (n)
  • 83.65 (a)
zebrafish
(Danio rerio)
Actinopterygii cdh7 35
  • 67.7 (n)
  • 74.56 (a)
cdh7 36
  • 72 (a)
OneToMany
CDH7 (1 of 2) 36
  • 58 (a)
OneToMany
Species with no ortholog for CDH7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH7 Gene

ENSEMBL:
Gene Tree for CDH7 (if available)
TreeFam:
Gene Tree for CDH7 (if available)

Paralogs for CDH7 Gene

Paralogs for CDH7 Gene

(25) SIMAP similar genes for CDH7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDH7: view

Variants for CDH7 Gene

Sequence variations from dbSNP and Humsavar for CDH7 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs756225 -- 65,828,704(-) TACAA(A/C/T)TGACC intron-variant
rs756284 -- 65,828,597(-) TGTTG(A/T)CCAGA intron-variant
rs756285 -- 65,828,720(-) AAAAA(C/T)GAGAT intron-variant
rs874767 -- 65,749,785(+) CTGGA(A/C)TGGGG upstream-variant-2KB
rs931288 -- 65,826,194(-) ATGCT(C/T)TTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH7 Gene

Variant ID Type Subtype PubMed ID
nsv909697 CNV Loss 21882294
nsv833675 CNV Gain 17160897
nsv909719 CNV Loss 21882294
nsv458102 CNV Loss 19166990
nsv909720 CNV Gain 21882294
esv268998 CNV Insertion 20981092
esv269715 CNV Insertion 20981092
esv274112 CNV Insertion 20981092
esv1064517 CNV Insertion 17803354
nsv828267 CNV Gain 20364138
nsv833676 CNV Gain 17160897
esv2521787 CNV Deletion 19546169
esv1954972 CNV Deletion 18987734
esv3413 CNV Deletion 18987735
esv2717231 CNV Deletion 23290073
esv1005846 CNV Deletion 20482838
esv1389809 CNV Deletion 17803354
esv6192 CNV Loss 19470904
esv1000701 CNV Deletion 20482838
nsv510462 CNV Loss 20534489

Variation tolerance for CDH7 Gene

Residual Variation Intolerance Score: 3.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH7 Gene

HapMap Linkage Disequilibrium report
CDH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH7 Gene

Disorders for CDH7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDH7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
charge syndrome
  • charge association
- elite association
Search CDH7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDH7

Genetic Association Database (GAD)
CDH7
Human Genome Epidemiology (HuGE) Navigator
CDH7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH7
genes like me logo Genes that share disorders with CDH7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH7 Gene

Publications for CDH7 Gene

  1. Cadherin-7 interacts with melanoma inhibitory activity protein and negatively modulates melanoma cell migration. (PMID: 19200257) Winklmeier A. … Bosserhoff A.K. (Cancer Sci. 2009) 23 67
  2. Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7. (PMID: 10995570) Kools P. … van Roy F. (Genomics 2000) 23 67
  3. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. (PMID: 9615235) Kremmidiotis G. … Callen D.F. (Genomics 1998) 2 67
  4. Common variants in the CDH7 gene are associated with major depressive disorder in the Han Chinese population. (PMID: 24554215) Li X. … Shi Y. (Behav. Genet. 2014) 67
  5. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. (PMID: 24025145) Chung S. … Nakamura Y. (Breast Cancer Res. 2013) 67

Products for CDH7 Gene

Sources for CDH7 Gene

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