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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDH7 Gene

protein-coding   GIFtS: 57
GCID: GC18P063390

cadherin 7, type 2

 Explore 3 diseases affiliated with
CDH7 via our new
 Human Malady Compendium 
Biological research products
for CDH7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cadherin 7, Type 21 2
CDH7L12 3
Cadherin-71

External Ids:    HGNC: 17661   Entrez Gene: 10052   Ensembl: ENSG000000811387   OMIM: 6058065   UniProtKB: Q9ULB53   

Export aliases for CDH7 gene to outside databases

Previous GC identifers: GC18P063262 GC18P061566 GC18P061568 GC18P060120


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDH7:
This gene is a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium
dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and
a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell
adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic
manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures. Alternative
splicing in the 5' UTR of this gene yields variant transcripts encoding the same protein. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: CADH7_HUMAN, Q9ULB5
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a
homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDH7 gene promoter:
         HOXA9   HOXA9B   NF-1   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDH7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDH7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDH7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.1   Ensembl cytogenetic band:  18q22.1   HGNC cytogenetic band: 18q22.1

CDH7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH7 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P063390:  view genomic region     (about GC identifiers)

Start:
63,417,488 bp from pter      End:
63,548,638 bp from pter
Size:
131,151 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CADH7_HUMAN, Q9ULB5 (See protein sequence)
Recommended Name: Cadherin-7 precursor  
Size: 785 amino acids; 87086 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q9H157

Explore the universe of human proteins at neXtProt for CDH7: NX_Q9ULB5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULB5

  • CDH7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_004352.2  NP_387450.1  

    ENSEMBL proteins: 
     ENSP00000319166   ENSP00000443030   ENSP00000381058  
    Reactome Protein details: Q9ULB5
    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
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    Uscn Proteins for CDH7

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS--


    CDH7 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CDH7 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q9ULB5

    ProtoNet protein and cluster: Q9ULB5

    2 Blocks protein families:
    IPB000233 Cadherin cytoplasmic region
    IPB002126 Cadherin


    UniProtKB/Swiss-Prot: CADH7_HUMAN, Q9ULB5
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections,
    imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 5 cadherin domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CADH7_HUMAN, Q9ULB5
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a
    homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

         Genatlas biochemistry entry for CDH7:
    BH-cadherin chicken cadherin 7-like,transmembrane glycoprotein component of adherens junction,with two alternatively
    spliced isoforms,the major transcript predominantly expressed in the brain,putatively involved in synaptic
    adhesion,axon outgrowth and guidance,heart,the minor expressed in several cancer lines

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--


    CDH7 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    Cell-cell junction organization1.00
    Adherens junctions interactions0.51
    Cell junction organization0.69
    Cell-Cell communication0.45
    2Rho Family GTPases
    Rho Family GTPases1.00
    ILK Signaling0.45
    3Neural Crest Differentiation
    Neural Crest Differentiation1.00
    4WNT Signaling
    WNT Signaling1.00
    5S-1P Stimulated Signaling
    S-1P Stimulated Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDH7 (see all 7)
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    Presenilin-Mediated Signaling

    1 BioSystems Pathway for CDH7 
        Neural Crest Differentiation

    4        Reactome Pathways for CDH7
        Adherens junctions interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization



    CDH7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDH7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for CDH7 (Q9ULB53 ENSP000003191664) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDH15P552913, ENSP000002897464I2D: score=1 STRING: ENSP00000289746
    CDH9Q9ULB43, ENSP000002310214I2D: score=1 STRING: ENSP00000231021
    CDH6P552853, ENSP000002650714I2D: score=1 STRING: ENSP00000265071
    CTNNB1P352223, ENSP000003444564I2D: score=2 STRING: ENSP00000344456
    CDH12P552893I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion NAS--
    GO:0016337cell-cell adhesion NAS10861224
    GO:0034329cell junction assembly TAS--
    GO:0034332adherens junction organization TAS--
    GO:0045216cell-cell junction organization TAS--


    CDH7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDH7

    1 HMDB Compound for CDH7    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CDH7 / CADH7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDH7 gene (2 alternative transcripts): 
    NM_004361.2  NM_033646.1  

    Unigene Cluster for CDH7:

    Cadherin 7, type 2
    Hs.657522  [show with all ESTs]
    Unigene Representative Sequence: BC036786
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000323011(uc002ljz.3) ENST00000536984(uc002lka.3) ENST00000397968(uc002lkb.3)
    ENST00000581601

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    Additional cDNA sequence: 

    AB035301.1 AJ007611.1 BC036786.1 

    5 DOTS entries:

    DT.40246867  DT.91717100  DT.91753655  DT.97809227  DT.95141633 

    14 AceView cDNA sequences:

    BF668216 F08808 AB035301 NM_004361 NM_033646 F11137 AJ007611 BC036786 
    BM560514 BU934923 BF701677 BF700598 BF697112 BF699960 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDH7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGGGCAGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CDH7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See CDH7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDH7

    SOURCE GeneReport for Unigene cluster: Hs.657522
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CDH7 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CDH71 cadherin 7, type 2 83.44(n)
    93.5(a)
      374007  NM_204187.2  NP_989518.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDH76
    --
    93(a)
    1 ↔ 1
    4(44694260-44775058)
    zebrafish
    (Danio rerio)
    Actinopterygii cdh71 cadherin 7, type 2 67.7(n)
    74.56(a)
      567704  NM_001077448.1  NP_001070916.1 


    ENSEMBL Gene Tree for CDH7 (if available)
    TreeFam Gene Tree for CDH7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDH7 gene
    CDH42  CDH182  DSG42  CDH32  CDH102  CDH112  CDH12  CDH62  
    DSC22  CDH82  CDH202  CDH222  DSC12  CDH192  DSG12  DSG22  
    CDH92  CDH122  CDH262  DSC32  CDH22  CDH242  CDH152  CDH52  
    DSG32  
    18/25 SIMAP similar genes for CDH7 using alignment to 3 protein entries:     CADH7_HUMAN (see all proteins) (see all similar genes):
    CDH9    Nbla04261    CDH8    CDH20    CDH18    CDH6
    CDH22    CDH10    CDH19    CDH12    CDH11    CDH24
    CDH2    FAT3    CDH4    CDH13    CDH5    ME5

    CDH7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2660 NCBI SNPs in CDH7 are shown (see all 2660    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs28779491,2
    A--60227513(+) aataaA/Tatagc 1 -- int10--------
    rs104601251,2
    C,F,A,H,--63415573(+) TCTTAC/TTTGCT 1 -- us2k130Minor allele frequency- T:0.39NS EA NA WA CSA 3134
    rs1404854021,2
    --63415599(+) CTTCCC/TCCTAA 1 -- us2k10--------
    rs1891239471,2
    --63415657(+) ATTCCA/GTATCT 1 -- us2k10--------
    rs1815152111,2
    --63415672(+) CTACAA/GCATAA 1 -- us2k10--------
    rs1444641441,2
    --63415679(+) ATAATA/CCATCT 1 -- us2k10--------
    rs104601261,2
    C,F,A,H,--63415698(+) CTCCCT/CTCCTG 1 -- us2k1 trp310Minor allele frequency- C:0.38NS NA WA CSA EA 490
    rs1477961311,2
    --63415731(+) CCTGCC/TGCAGA 1 -- us2k10--------
    rs1401543281,2
    --63415802(+) ATTGTC/TATCAT 1 -- us2k10--------
    rs1503244961,2
    --63415823(+) CCTATG/TTGCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDH7 (63417488 - 63548638 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for CDH7
         1 CNV: 102693
         4 Indels: 61629 45673 26089 42504

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDH7 for disorders           About GeneDecksing

    OMIM gene information: 605806    OMIM disorders: --

    3 diseases for CDH7:    About MalaCards
    mammary paget's disease    charge syndrome    melanoma

    Human Genome Epidemiology (HuGE) Navigator: CDH7 (3 documents)

    Export disorders for CDH7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDH7 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with CDH7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7. (PubMed id 10995570)1, 2, 9 Kools P.... van Roy F. (2000)
    2. Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. (PubMed id 10861224)1, 2 Shimoyama Y.... Natori M. (2000)
    3. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. (PubMed id 9615235)1, 3 Kremmidiotis G....Callen D.F. (1998)
    4. Cadherin-7 interacts with melanoma inhibitory activity protein and negatively modulates melanoma cell migration. (PubMed id 19200257)1, 9 Winklmeier A....Bosserhoff A.K. (2009)
    5. CHD7 mutations and CHARGE syndrome: the clinical impl ications of an expanding phenotype. (PubMed id 21378379)1 Bergman J.E....van Ravenswaaij-Arts C.M. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
    8. Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation. (PubMed id 15273735)1 Moore R....Larue L. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. (PubMed id 9219219)1 Ali J.... Muller W.A. (1997)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1005 HGNC: 1766 AceView: CDH7 Ensembl:ENSG00000081138 euGenes: HUgn1005
    ECgene: CDH7 H-InvDB: CDH7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for CDH7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDH7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDH7 gene:
    Search GeneIP for patents involving CDH7

    GeneCards and IP:
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