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CDH6 Gene

protein-coding   GIFtS: 63
GCID: GC05P031229

Cadherin 6, Type 2, K-Cadherin (Fetal Kidney)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cadherin 6, Type 2, K-Cadherin (Fetal Kidney)1 2     cadherin-62
K-Cadherin1     K-cadherin3
CAD62     Kidney Cadherin3
KCAD2     

External Ids:    HGNC: 17651   Entrez Gene: 10042   Ensembl: ENSG000001133617   OMIM: 6030075   UniProtKB: P552853   

Export aliases for CDH6 gene to outside databases

Previous GC identifers: GC05P030978 GC05P031640 GC05P031193 GC05P031239


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDH6 Gene:
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate
homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded
protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta
formation. Decreased expression of this gene may be associated with tumor growth and metastasis. (provided by
RefSeq, May 2011)

GeneCards Summary for CDH6 Gene:
CDH6 (cadherin 6, type 2, K-cadherin (fetal kidney)) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH18.

UniProtKB/Swiss-Prot: CADH6_HUMAN, P55285
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Wiki entry for CDH6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDH6 gene promoter:
         E2F-4   E2F-3a   E2F-5   Nkx2-5   E2F-2   POU3F2   FOXL1   Evi-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDH6 promoter sequence
   Search Chromatin IP Primers for CDH6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDH6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.3   Ensembl cytogenetic band:  5p13.3   HGNC cytogenetic band: 5p13.3

CDH6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P031229:  view genomic region     (about GC identifiers)

Start:
31,193,762 bp from pter      End:
31,329,253 bp from pter
Size:
135,492 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CADH6_HUMAN, P55285 (See protein sequence)
Recommended Name: Cadherin-6 precursor  
Size: 790 amino acids; 88309 Da
Secondary accessions: A8K5H5 Q9BWS0
Alternative splicing: 2 isoforms:  P55285-1   P55285-2   

Explore the universe of human proteins at neXtProt for CDH6: NX_P55285

Explore proteomics data for CDH6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn49, Asn255, Asn399, Asn437, Asn455, Asn536
  • Modification sites at PhosphoSitePlus

  • See CDH6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004923.1  
    ENSEMBL proteins: 
     ENSP00000424843   ENSP00000265071  
    Reactome Protein details: P55285

    CDH6 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CDH6
    Sino Biological Cell Lysate for CDH6
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CDH6 

     
    antibodies-online proteins for CDH6 (15 products) 

     
    antibodies-online peptides for CDH6

    CDH6 Antibody Products:

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    antibodies-online antibodies for CDH6 (53 products) 

    CDH6 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for CDH6 
    antibodies-online kits for CDH6 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MCDH: Cadherins / Major cadherins

    5 InterPro protein domains:
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR027397 Catenin_binding_dom
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry P55285

    ProtoNet protein and cluster: P55285

    2 Blocks protein domains:
    IPB000233 Cadherin cytoplasmic region
    IPB002126 Cadherin


    UniProtKB/Swiss-Prot: CADH6_HUMAN, P55285
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the
    connections, imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 5 cadherin domains


    Find genes that share domains with CDH6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CADH6_HUMAN, P55285
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
    a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

         Genatlas biochemistry entry for CDH6:
    cadherin 6,K-cadherin,transmembrane glycoprotein component of adherens junction,expressed in fetal kidney

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with CDH6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CDH6:
     Increased cell transformation 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cdh6):
     nervous system  no phenotypic analysis  renal/urinary system 

    Find genes that share phenotypes with CDH6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CDH6: Cdh6tm1Nosu Cdh6tm1Sma

       genOway: Develop your customized and physiologically relevant rodent model for CDH6

    miRNA
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    miRTarBase miRNAs that target CDH6:
    hsa-mir-155-5p (MIRT020970)

    Block miRNA regulation of human, mouse, rat CDH6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDH6 (see all 75):
    hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-607 hsa-miR-520e hsa-miR-376b hsa-miR-219-5p hsa-miR-138-2* hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidCDH6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDH6
    Predesigned siRNA for gene silencing in human, mouse, rat CDH6

    Gene Editing
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    Sino Biological Human cDNA Clone for CDH6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH6

    Cell Line
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    ESI BIO PureStem Progenitors for CDH6: 
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    PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CADH6_HUMAN, P55285: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    cytosol3
    mitochondrion2
    cytoskeleton1
    extracellular1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CDH6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDH6 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Adherens junctions interactions0.49
    2ERK Signaling
    Rho Family GTPases0.61
    ILK Signaling0.49
    3Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    4Non-Canonical Wnt Pathway
    Canonical Wnt Pathway0.53
    5WNT Signaling
    WNT Signaling


    Find genes that share SuperPaths with CDH6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDH6 (see all 7)
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    Presenilin-Mediated Signaling

    1 BioSystems Pathway for CDH6
        Neural Crest Differentiation

    1 Sino Biological Pathway for CDH6
        Canonical Wnt Pathway

    1 Reactome Pathway for CDH6
        Adherens junctions interactions


        Pathway & Disease-focused RT2 Profiler PCR Array including CDH6: 
              Tumor Metastasis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CDH6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for CDH6 (P552853 ENSP000002650714) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDH18Q136343, ENSP000002741704I2D: score=2 STRING: ENSP00000274170
    CDH19Q9H1593, ENSP000002621504I2D: score=1 STRING: ENSP00000262150
    CDH7Q9ULB53, ENSP000003191664I2D: score=1 STRING: ENSP00000319166
    CDH9Q9ULB43, ENSP000002310214I2D: score=1 STRING: ENSP00000231021
    CDH10Q9Y6N83, ENSP000002644634I2D: score=1 STRING: ENSP00000264463
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS7743525
    GO:0007156homophilic cell adhesion IEA--
    GO:0034329cell junction assembly TAS--
    GO:0034332adherens junction organization TAS--
    GO:0045216cell-cell junction organization TAS--

    Find genes that share ontologies with CDH6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDH6 (CADH6)

    1 HMDB Compound for CDH6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDH6 gene: 
    NM_004932.3  

    Unigene Clusters for CDH6:

    Cadherin 6, type 2, K-cadherin (fetal kidney)
    Hs.124776  [show with all ESTs], Hs.171054  [show with all ESTs]
    Unigene Representative Sequences: NM_004932, AK024238
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514738(uc003jhd.2) ENST00000265071(uc003jhe.2) ENST00000506396(uc003jhc.2)
    ENST00000508132 ENST00000504835
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDH6 (see all 75):
    hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-607 hsa-miR-520e hsa-miR-376b hsa-miR-219-5p hsa-miR-138-2* hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidCDH6 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat CDH6

    Additional mRNA sequence: 

    AK024238.1 BC013907.2 

    6 DOTS entries:

    DT.109045  DT.95254951  DT.95093742  DT.97807302  DT.100742552  DT.100740803 

    Selected AceView cDNA sequences (see all 78):

    BU859059 D31784 AU130185 AI650769 AI949815 BF593396 AA421819 AI089074 
    AI269353 NM_004932 AI831718 BU849782 BE816999 CA314682 BE466075 AW195329 
    BE271817 BU553660 AI813450 AW237811 BE273648 BE514814 BC013907 AU129330 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDH6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAGTTTTC
    CDH6 Expression
    About this image


    CDH6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Kidney (Urinary System)    fully expand to see all 13 entries
             S-shaped Body Medial Cells S-shaped Body Medial Segment
             Metanephros
             mK4
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
    CDH6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDH6 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.124776 Hs.171054

    UniProtKB/Swiss-Prot: CADH6_HUMAN, P55285
    Tissue specificity: Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a
    weak expression. Also expressed in certain liver and kidney carcinomas

        Pathway & Disease-focused RT2 Profiler PCR Array including CDH6: 
              Tumor Metastasis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDH6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdh61 , 5 cadherin 61, 5 90.51(n)1
    97.09(a)1
      15 (6.11 cM)5
    125631  NM_007666.31  NP_031692.21 
     130342005 
    chicken
    (Gallus gallus)
    Aves CDH61 cadherin 6, type 2, K-cadherin (fetal kidney) 80.8(n)
    87.22(a)
      414842  NM_001001758.1  NP_001001758.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDH66
    cadherin 6, type 2, K-cadherin (fetal kidney)
    85(a)
    1 ↔ 1
    GL343408.1(436940-570161)
    African clawed frog
    (Xenopus laevis)
    Amphibia cdh6-A2 cadherin 6, type 2, K-cadherin 76.78(n)    AF263272.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdh61 cadherin 6 65.81(n)
    66.24(a)
      541393  NM_001013520.1  NP_001013538.1 


    ENSEMBL Gene Tree for CDH6 (if available)
    TreeFam Gene Tree for CDH6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDH6 gene
    CDH182  CDH222  CDH192  CDH102  CDH112  CDH72  CDH92  CDH122  
    CDH82  CDH242  CDH202  CDH52  
    Selected SIMAP similar genes for CDH6 using alignment to 3 protein entries:     CADH6_HUMAN (see all proteins) (see all similar genes):
    CDH9    CDH10    Nbla04261    CDH18    CDH20    CDH7
    CDH11    CDH8    CDH12    CDH22    CDH24    CDH19
    CDH5    CDH2    CDH4    FAT3    ME5    CDH15

    Find genes that share paralogs with CDH6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDH6 (see all 2744)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424915221,2
    C--31191823(+) AAGAAC/TAGTAT 1 -- us2k10--------
    rs1509370661,2
    --31191832(+) ATATTA/GCAAAC 1 -- us2k10--------
    rs1844524841,2
    --31191852(+) TTTCCG/TTTGTG 1 -- us2k10--------
    rs38068511,2
    C,F,A,H--31191910(-) TGGTAA/GAAGAG 1 -- us2k134Minor allele frequency- N:0.00EA NA NS WA CSA 4074
    rs1884111041,2
    C--31191948(+) TCTGCA/TAAAGG 1 -- us2k10--------
    rs77347031,2
    C,F,H--31191992(+) TTTACG/ATATTA 1 -- us2k1 tfbs35Minor allele frequency- A:0.02NS EA WA 526
    rs1403245621,2
    C--31192029(+) CATATA/GCTAAT 1 -- us2k10--------
    rs38223651,2
    C,F,A,H--31192038(-) GTATAA/CTTTAT 1 -- us2k128Minor allele frequency- N:0.00EA NA NS CSA WA 2960
    rs1926884871,2
    --31192390(+) TCATAC/TGTGTT 1 -- us2k10--------
    rs1118289721,2
    C,F--31192406(+) AGCTCT/AATAAA 1 -- us2k12Minor allele frequency- A:0.04NA 122

    HapMap Linkage Disequilibrium report for CDH6 (31193762 - 31329253 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CDH6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830247CNV Gain17160897
    dgv1788e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDH6
    DNA2.0 Custom Variant and Variant Library Synthesis for CDH6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603007    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CDH6:
    Renal cell carcinoma

    Find genes that share disorders with CDH6           About GenesLikeMe

    1 Novoseek inferred disease relationship for CDH6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 38.3 3 8187093 (2), 7743525 (1)

    Genetic Association Database (GAD): CDH6

    Export disorders for CDH6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDH6 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with CDH6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells. (PubMed id 7743525)1, 2, 3, 9 Shimoyama Y.... Hirohashi S. (Cancer Res. 1995)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. (PubMed id 10191097)1, 3 Chalmers I.J....Atkinson M.J. (Genomics 1999)
    6. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PubMed id 2059658)1, 2 Suzuki S.... Tanihara H. (Cell Regul. 1991)
    7. Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. (PubMed id 20709820)1 Kong X....Pillai S.G. (Am. J. Respir. Crit. Care Med. 2011)
    8. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Polycomb target genes are silenced in multiple myeloma. (PubMed id 20634887)1 Kalushkova A....Jernberg-Wiklund H. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1004 HGNC: 1765 AceView: CDH6 Ensembl:ENSG00000113361 euGenes: HUgn1004
    ECgene: CDH6 H-InvDB: CDH6

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDH6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDH6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDH6 gene:
    Search GeneIP for patents involving CDH6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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