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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDH6 Gene

protein-coding   GIFtS: 64
GCID: GC05P031229

cadherin 6, type 2, K-cadherin (fetal kidney)
 Explore 5 diseases affiliated with
CDH6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDH6    

Aliases
for CDH6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cadherin 6, Type 2, K-Cadherin (Fetal Kidney)1 2
CAD62
KCAD2
Cadherin-61
K-Cadherin1
Kidney Cadherin3

External Ids:    HGNC: 17651   Entrez Gene: 10042   Ensembl: ENSG000001133617   OMIM: 6030075   UniProtKB: P552853   

Export aliases for CDH6 gene to outside databases

Previous GC identifers: GC05P030978 GC05P031640 GC05P031193 GC05P031239


Summaries
for CDH6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDH6:
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic
cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II
cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression
of this gene may be associated with tumor growth and metastasis. (provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: CADH6_HUMAN, P55285
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a
homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Wiki entry for CDH6


Genomic Views
for CDH6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDH6 gene promoter:
         E2F-4   E2F-3a   E2F-5   Nkx2-5   E2F-2   POU3F2   FOXL1   Evi-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDH6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDH6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDH6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.3   Ensembl cytogenetic band:  5p13.3   HGNC cytogenetic band: 5p13.3

CDH6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P031229:  view genomic region     (about GC identifiers)

Start:
 31,193,796 bp from pter      End:
 31,329,253 bp from pter
Size:
 135,458 bases      Orientation:
 plus strand

Proteins
for CDH6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CADH6_HUMAN, P55285 (See protein sequence)
Recommended Name: Cadherin-6 precursor  
Size: 790 amino acids; 88309 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: A8K5H5 Q9BWS0
Alternative splicing: 2 isoforms:  P55285-1   P55285-2   

Explore the universe of human proteins at neXtProt for CDH6: NX_P55285

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55285

    • CDH6 Protein expression data from MOPED and PaxDb:    About this image 
    CDH6 Protein Expression
    REFSEQ proteins: NP_004923.1  
    ENSEMBL proteins: 
     ENSP00000424843   ENSP00000265071  
    Reactome Protein details: P55285
    Human Recombinant Protein Products for CDH6: 
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    R&D Systems Recombinant & Natural Proteins for CDH6 (Cadherin-6/KCAD)
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    Novus Biologicals CDH6 Proteins
    Novus Biologicals CDH6 Lysate
    Sino Biological Recombinant Protein for CDH6
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDH6

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    CDH6 for ontologies           About GeneDecksing



    CDH6 Antibody Products: 
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    ThermoFisher Antibodies for CDH6

    Assay Products for CDH6: 
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    Uscn ELISAs and CLIAs for CDH6

    Protein Domains /
    Families
    for CDH6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDH6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry P55285

    ProtoNet protein and cluster: P55285

    2 Blocks protein families:
    IPB000233 Cadherin cytoplasmic region
    IPB002126 Cadherin


    UniProtKB/Swiss-Prot: CADH6_HUMAN, P55285
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections,
    imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 5 cadherin domains


    Function
    for CDH6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CADH6_HUMAN, P55285
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a
    homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

         Genatlas biochemistry entry for CDH6:
    cadherin 6,K-cadherin,transmembrane glycoprotein component of adherens junction,expressed in fetal kidney

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    CDH6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDH6:
     Increased cell transformation 

         3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cdh6):
     nervous system  no phenotypic analysis  renal/urinary system 

    CDH6 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for CDH6: Cdh6tm1Nosu Cdh6tm1Sma
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDH6 

    miRNA
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    Browse MicroRNA Expression Plasmids
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    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate CDH6 (see all 75):
    hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-607 hsa-miR-520e hsa-miR-376b hsa-miR-219-5p hsa-miR-138-2* hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: CDH6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDH6 (see all 7)
    OriGene shRNA RFP: CDH6
    OriGene siRNA: CDH6
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    Sirion Biotech Custom design and validation of potent shRNA sequences against CDH6 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CDH6 
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDH6 (see all 3)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CDH6 (NM_004932)
    Sino Biological Human cDNA Clone for CDH6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH6 

    Cell Line
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    LifeMap BioReagents: cell lines associated with CDH6: PureStem 7PEND24, NCr-fac & Meso-prx Progenitor,
    PureStem E15, Meso-prx/latp Progenitor, PureStem ES-210, Ecto-ntu Progenitor
    Sirion Biotech Customized stable knockdown cell line services for CDH6 
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    Sirion Biotech Customized inducible overexpressing cell line services for CDH6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH6


    Pathways & Interactions
    for CDH6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Adherens junctions interactions0.51
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		ILK Signaling0.45
    3Neural Crest Differentiation
    		Neural Crest Differentiation1.00
    4WNT Signaling
    		WNT Signaling1.00
    5S-1P Stimulated Signaling
    		S-1P Stimulated Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDH6 (see all 7)
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    Presenilin-Mediated Signaling

    1 BioSystems Pathway for CDH6 
        Neural Crest Differentiation

    4        Reactome Pathways for CDH6
        Adherens junctions interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization



    CDH6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDH6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for CDH6 (P552853 ENSP000002650714) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDH18Q136343, ENSP000002741704I2D: score=2 STRING: ENSP00000274170
    CDH19Q9H1593, ENSP000002621504I2D: score=1 STRING: ENSP00000262150
    CDH7Q9ULB53, ENSP000003191664I2D: score=1 STRING: ENSP00000319166
    CDH9Q9ULB43, ENSP000002310214I2D: score=1 STRING: ENSP00000231021
    CDH10Q9Y6N83, ENSP000002644634I2D: score=1 STRING: ENSP00000264463
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS7743525
    GO:0007156homophilic cell adhesion IEA--
    GO:0034329cell junction assembly TAS--
    GO:0034332adherens junction organization TAS--
    GO:0045216cell-cell junction organization TAS--

    CDH6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDH6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDH6

    1 HMDB Compound for CDH6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CDH6 / CADH6 

    Transcripts
    for CDH6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDH6 gene: 
    NM_004932.3  

    Unigene Clusters for CDH6:

    Cadherin 6, type 2, K-cadherin (fetal kidney)
    Hs.124776  [show with all ESTs], Hs.171054  [show with all ESTs]
    Unigene Representative Sequences: NM_004932, AK024238
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514738(uc003jhd.2) ENST00000265071(uc003jhe.2) ENST00000506396(uc003jhc.2)
    ENST00000508132 ENST00000504835

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CDH6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDH6
    8/75 QIAGEN miScript miRNA Assays for microRNAs that regulate CDH6 (see all 75):
    hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-607 hsa-miR-520e hsa-miR-376b hsa-miR-219-5p hsa-miR-138-2* hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmid: CDH6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDH6 (see all 7)
    OriGene shRNA RFP: CDH6
    OriGene siRNA: CDH6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDH6
    Sirion Biotech Custom design and validation of potent shRNA sequences against CDH6 
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK024238.1 BC013907.2 

    6 DOTS entries:

    DT.109045  DT.95254951  DT.95093742  DT.97807302  DT.100742552  DT.100740803 

    24/78 AceView cDNA sequences (see all 78):

    BU849782 AI949815 AU130185 NM_004932 AI650769 BU859059 AI269353 BE816999 
    AA421819 BF593396 AI831718 AI089074 D31784 AU149929 CA313727 AW237811 
    AW614367 AI091237 AW024839 BE315149 BX641560 AW195329 AU129330 CB047092 

    GeneLoc Exon Structure


    Expression
    for CDH6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDH6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCAGTTTTC
    CDH6 Expression
    About this image

    CDH6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped Body Medial SegmentS-shaped Body Medial CellsKidney
    KidneyRenal VesicleDistal Renal Vesicle CellsKidney
    KidneyRenal VesicleProximal Renal Vesicle CellsKidney
    Neural EctodermNeural PlateSpinal Neural Plate CellsNeural Ectoderm
    KidneyComma-shaped BodyComma-shaped Body CellsKidney
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    KidneyComma-shaped BodyKidney
    KidneyEpithelial TubuleKidney
    KidneyLoop of HenleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/15 LifeMap Cells (see all 15) 
    NameCategory
    mK4 (Cell line)Kidney
    mK3 (Cell line)Kidney
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

    See CDH6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDH6

    SOURCE GeneReport for Unigene clusters: Hs.124776 Hs.171054

    UniProtKB/Swiss-Prot: CADH6_HUMAN, P55285
    Tissue specificity: Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak
    expression. Also expressed in certain liver and kidney carcinomas

        SABiosciences Expression via Pathway-Focused PCR Array including CDH6: 
              Tumor Metastasis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH6

    Orthologs
    for CDH6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CDH6 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cdh61 , 5 cadherin 61, 5 90.51(n)1
    97.09(a)1    		   15 (6.11 cM)5
    125631  NM_007666.31  NP_031692.21 
     130342005 
    chicken
    (Gallus gallus)    		 Aves CDH61 cadherin 6, type 2, K-cadherin (fetal kidney) 80.8(n)
    87.22(a)    		   414842  NM_001001758.1  NP_001001758.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CDH66
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL343408.1(436940-504723)
    African clawed frog
    (Xenopus laevis)    		 Amphibia cdh6-A2 cadherin 6, type 2, K-cadherin 76.78(n)    AF263272.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cdh61 cadherin 6 65.64(n)
    65.9(a)    		   541393  NM_001013520.1  NP_001013538.1 


    ENSEMBL Gene Tree for CDH6 (if available)
    TreeFam Gene Tree for CDH6 (if available) 

    Paralogs
    for CDH6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDH6 gene
    CDH42  CDH182  DSG42  CDH32  CDH102  CDH112  CDH12  DSC22  
    CDH82  CDH202  CDH222  DSC12  CDH192  DSG12  CDH72  DSG22  
    CDH92  CDH122  CDH262  DSC32  CDH22  CDH242  CDH152  CDH52  
    DSG32  
    18/22 SIMAP similar genes for CDH6 using alignment to 3 protein entries:     CADH6_HUMAN (see all proteins) (see all similar genes):
    CDH9    CDH10    Nbla04261    CDH18    CDH20    CDH7
    CDH11    CDH8    CDH12    CDH22    CDH24    CDH19
    CDH2    CDH4    FAT3    ME5    CDH5    CDH15

    CDH6 for paralogs           About GeneDecksing



    Genomic Variants
    for CDH6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2396 NCBI SNPs in CDH6 are shown (see all 2396)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1424915221,2
    		--31191823(+) AAGAAC/TAGTAT 1 -- us2k10--------
    rs1509370661,2
    		--31191832(+) ATATTA/GCAAAC 1 -- us2k10--------
    rs1844524841,2
    		--31191852(+) TTTCCG/TTTGTG 1 -- us2k10--------
    rs38068511,2
    		C,F,A,H--31191910(-) TGGTAA/GAAGAG 1 -- us2k134Minor allele frequency- N:0.00EA NA NS WA CSA 4074
    rs1884111041,2
    		--31191948(+) TCTGCA/TAAAGG 1 -- us2k10--------
    rs77347031,2
    		C,H--31191992(+) TTTACG/ATATTA 1 -- us2k1 tfbs35Minor allele frequency- A:0.02NS EA WA 526
    rs1403245621,2
    		--31192029(+) CATATA/GCTAAT 1 -- us2k10--------
    rs38223651,2
    		C,F,A,H--31192038(-) GTATAA/CTTTAT 1 -- us2k128Minor allele frequency- N:0.00EA NA NS CSA WA 2960
    rs1926884871,2
    		--31192390(+) TCATAC/TGTGTT 1 -- us2k10--------
    rs1118289721,2
    		C--31192406(+) AGCTCT/AATAAA 1 -- us2k12Minor allele frequency- A:0.04NA 122

    HapMap Linkage Disequilibrium report for CDH6 (31193796 - 31329253 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CDH6
         1 CNV: 3550

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    Disorders / Diseases
    for CDH6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDH6 for disorders           About GeneDecksing

    OMIM gene information: 603007    OMIM disorders: --

    5 diseases for CDH6:    About MalaCards
    renal cell carcinoma    emphysema    ovarian carcinoma    lung carcinoma
    carcinoma

    1 disease from the University of Copenhagen DISEASES database for CDH6:
    Renal cell carcinoma

    1 Novoseek disease relationship for CDH6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 38.3 3 8187093 (2), 7743525 (1)


    Export disorders for CDH6 gene to outside databases

    Publications
    for CDH6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDH6 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with CDH6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells. (PubMed id 7743525)1, 2, 3, 9 Shimoyama Y.... Hirohashi S. (1995)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. (PubMed id 10191097)1, 3 Chalmers I.J....Atkinson M.J. (1999)
    6. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PubMed id 2059658)1, 2 Suzuki S....Tanihara H. (1991)
    7. Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757)1 Chambers J.C....Kooner J.S. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. Genome-wide Association Study Identifies BICD1 as a S usceptibility Gene for Emphysema. (PubMed id 20709820)1 Kong X....Pillai S.G. (2010)
    10. Polycomb target genes are silenced in multiple myelom a. (PubMed id 20634887)1 Kalushkova A....Jernberg-Wiklund H. (2010)

    External Searches for CDH6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CDH6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1004 HGNC: 1765 AceView: CDH6 Ensembl:ENSG00000113361 euGenes: HUgn1004
    ECgene: CDH6 H-InvDB: CDH6

    Other Databases showing CDH6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDH6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDH6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDH6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CDH6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDH6 gene:
    Search GeneIP for patents involving CDH6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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