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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDH5 Gene

protein-coding   GIFtS: 71
GCID: GC16P066400

cadherin 5, type 2 (vascular endothelium)

(Previous names: cadherin 5, type 2, VE-cadherin (vascular epithelium) )
 Explore 50 diseases affiliated with
CDH5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDH5    

Aliases
for CDH5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cadherin 5, Type 2 (Vascular Endothelium)1 2     Vascular Endothelial Cadherin2 3
7B41 2     7B4 Antigen2 3
CD1441 2     VE-Cadherin1
Cadherin 5, Type 2, VE-Cadherin (Vascular Epithelium)1 2     Cadherin-51
CD144 Antigen2 3     Endothelial-Specific Cadherin2

External Ids:    HGNC: 17641   Entrez Gene: 10032   Ensembl: ENSG000001797767   OMIM: 6011205   UniProtKB: P331513   

Export aliases for CDH5 gene to outside databases

Previous GC identifers: GC16P056984 GC16P066658 GC16P066136 GC16P066176 GC16P064958 GC16P052277


Summaries
for CDH5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDH5:
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on
the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The
encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin
repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by
imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial
cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice
variant has been described but its full length sequence has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CADH5_HUMAN, P33151
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a
homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This
cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the
intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with
KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by
recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the
localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction

Gene Wiki entry for CDH5 (VE-cadherin)


Genomic Views
for CDH5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDH5 gene promoter:
         AML1a   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDH5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDH5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDH5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q22.1

CDH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066400:  view genomic region     (about GC identifiers)

Start:
 66,400,525 bp from pter      End:
 66,438,689 bp from pter
Size:
 38,165 bases      Orientation:
 plus strand

Proteins
for CDH5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CADH5_HUMAN, P33151 (See protein sequence)
Recommended Name: Cadherin-5 precursor  
Size: 784 amino acids; 87528 Da
Subunit: Interacts via cadherin 5 domain with PTPRB (By similarity). Interacts with TRPC4. Interacts with KRIT1
Subcellular location: Cell junction. Cell membrane; Single-pass type I membrane protein (Probable). Note=Found at
cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization
to endothelial cell-cell junctions

Explore the universe of human proteins at neXtProt for CDH5: NX_P33151

Post-translational modifications:

  • Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P33151

    • CDH5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001786.2  
    ENSEMBL proteins: 
     ENSP00000344115   ENSP00000456028   ENSP00000455302   ENSP00000456093   ENSP00000455655  
     ENSP00000458878   ENSP00000461880  
    Reactome Protein details: P33151
    Human Recombinant Protein Products: 
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    Novus Biologicals CDH5 Protein
    Sino Biological Recombinant Protein for CDH5
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDH5

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction IDA19996314
    GO:0005923tight junction IEA--
    GO:0016020membrane TAS9219219


    CDH5 for ontologies           About GeneDecksing



    CDH5 Antibody Products: 
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    ThermoFisher Antibodies for CDH5

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    Uscn ELISAs and CLIAs for CDH5

    Protein Domains /
    Families
    for CDH5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDH5 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry P33151

    ProtoNet protein and cluster: P33151

    2 Blocks protein families:
    IPB000233 Cadherin cytoplasmic region
    IPB002126 Cadherin


    UniProtKB/Swiss-Prot: CADH5_HUMAN, P33151
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections,
    imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 5 cadherin domains


    Function
    for CDH5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CADH5_HUMAN, P33151
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a
    homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This
    cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the
    intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with
    KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by
    recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the
    localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction

         Genatlas biochemistry entry for CDH5:
    cadherin 5,VE-cadherin,transmembrane glycoprotein component of adherens junction,expressed in vascular
    endothelium,integrity and normal organ function required for vascular

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDH5
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CDH5 (see all 26):
    hsa-miR-576-3p hsa-miR-125a-5p hsa-miR-513a-5p hsa-miR-767-5p hsa-miR-128 hsa-miR-501-3p hsa-miR-502-3p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmid: CDH5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDH5 (see all 7)
    OriGene shRNA RFP: CDH5
    OriGene siRNA: CDH5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDH5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CDH5

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDH5 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: CDH5 (NM_001795)
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    Cell Line
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    Search LifeMap BioReagents cell lines for CDH5

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH5

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI12088286
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
    GO:0008013beta-catenin binding IPI18287330
    GO:0019903protein phosphatase binding IEA--


    CDH5 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CDH5:
     Decreased viability with carbo  Decreased viability with pacli  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for CDH5: Cdh5tm2Pec Cdh5tm1Pec Cdh5tm1Hub Cdh5tm1.1Pec
         11 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Cdh5):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size 
     hematopoietic system  immune system  integument  mortality/aging  normal 
     vision/eye 

    CDH5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDH5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Adherens junctions interactions0.51
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    2Cell adhesion Endothelial cell contacts by junctional mechanisms
    		Cell adhesion Endothelial cell contacts by junctional mechanisms1.00
    		Cell adhesion_Endothelial cell contacts by junctional mechanisms0.97
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		ILK Signaling0.45
    4Cytoskeleton remodeling Slit-Robo signaling
    		Cell adhesion Cadherin-mediated cell adhesion0.28
    		Cell adhesion_Cadherin-mediated cell adhesion0.28
    5Angiogenesis
    		Angiogenesis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for CDH5
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Cadherin-mediated cell adhesion

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDH5 (see all 8)
        S-1P Stimulated Signaling
    G12-G13 in Cellular Signaling
    Transendothelial Migration of Leukocytes
    ILK Signaling
    GSK3 Signaling

    2 Cell Signaling Technology (CST) Pathways for CDH5
        Angiogenesis
    Adhesion

    2 GeneGo (Thomson Reuters) Pathways for CDH5
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Cadherin-mediated cell adhesion

    2 BioSystems Pathways for CDH5 
        Signaling events mediated by VEGFR1 and VEGFR2
    S1P2 pathway

    4        Reactome Pathways for CDH5
        Adherens junctions interactions
    Cell junction organization
    Cell-Cell communication
    Cell-cell junction organization


    2         Kegg Pathways  (Kegg details for CDH5):
        Cell adhesion molecules (CAMs)
    Leukocyte transendothelial migration


    CDH5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDH5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for CDH5 (P331512, 3 ENSP000003441154) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW02, 3, ENSP000003639214MINT-4085723 MINT-4085234 MINT-4085272 MINT-4085739 MINT-4085197 MINT-4085447 I2D: score=2 STRING: ENSP00000363921
    SHC1P293532, 3, ENSP000004013034MINT-49635 MINT-49636 I2D: score=3 STRING: ENSP00000401303
    CTNNA1P352212, 3, ENSP000003046694MINT-4085212 I2D: score=2 STRING: ENSP00000304669
    PARD6AQ9NPB62, 3, ENSP000002192554MINT-4085643 MINT-4085515 MINT-4085595 MINT-4085759 I2D: score=3 STRING: ENSP00000219255
    CTNNB1P352222, 3, ENSP000003444564MINT-4085223 MINT-4085471 I2D: score=6 STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001955blood vessel maturation IEA--
    GO:0007156homophilic cell adhesion IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0034329cell junction assembly TAS--
    GO:0034332adherens junction organization TAS--


    CDH5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDH5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDH5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDH5

    1 HMDB Compound for CDH5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for CDH5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LenalidomideCC-5013 (see all 3)191732-72-6targetantagonist18805433

    10/30 Novoseek chemical compound relationships for CDH5 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 72.1 117 16683386 (6), 15708125 (5), 18180305 (5), 18780647 (4) (see all 52)
    matrigel 71.5 8 17569886 (1), 19760520 (1), 15370292 (1), 15735710 (1) (see all 8)
    tyrosine 52.9 96 10681592 (4), 12234928 (4), 12219009 (4), 16909109 (3) (see all 44)
    phosphotyrosine 34 3 19715693 (1), 9378757 (1)
    cytochalasin d 25.9 1 9120301 (1)
    dextran 23.3 1 19944695 (1)
    phosphoinositide 23 1 16962712 (1)
    histamine 21.4 23 15220112 (5), 18287330 (5), 12003790 (4), 10521356 (3) (see all 6)
    nitric oxide 19.1 12 19037921 (2), 16574915 (1), 19563553 (1), 16507070 (1) (see all 9)
    forskolin 11.6 13 20032304 (4), 15475517 (2), 19789809 (1)

    Search CenterWatch for drugs/clinical trials and news about CDH5 / CADH5 

    Transcripts
    for CDH5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDH5 gene (2 alternative transcripts): 
    NM_001795.3  NM_001114117.1  

    Unigene Cluster for CDH5:

    Cadherin 5, type 2 (vascular endothelium)
    Hs.76206  [show with all ESTs]
    Unigene Representative Sequence: NM_001795
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341529(uc002eom.4) ENST00000565334 ENST00000562048 ENST00000568155
    ENST00000568023 ENST00000563425(uc002eon.1) ENST00000539168

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDH5
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CDH5 (see all 26):
    hsa-miR-576-3p hsa-miR-125a-5p hsa-miR-513a-5p hsa-miR-767-5p hsa-miR-128 hsa-miR-501-3p hsa-miR-502-3p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmid: CDH5 3' UTR sequence
    Inhib. RNA
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH5 
    Primer
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    Additional cDNA sequence: 

    AB035304.1 AB209908.1 AK300299.1 AK300322.1 AK300461.1 BC096363.3 BC096364.3 BC096365.1 
    BC117520.2 U84722.1 X59796.1 X79981.1 

    10 DOTS entries:

    DT.415056  DT.120691480  DT.40279949  DT.92423053  DT.95165092  DT.40221688  DT.92041742  DT.92423051 
    DT.95165089  DT.95165090 

    24/101 AceView cDNA sequences (see all 101):

    R63469 BP362670 AI801770 BQ022023 AA181178 BU732589 BU616085 AA903073 
    BM710619 CR604654 AI362402 AA368240 N22448 CA425506 AI360970 BQ716387 
    AL546985 AA346693 CR595820 NM_001795 AW104445 AU138341 T29828 BF590256 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CDH5 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                          -     -     -                                                                                                               
    SP2:                          -     -     -                                                                       -     -     -                           
    SP3:                          -     -     -                                                                                                               
    SP4:                                -     -                                                                                                               
    SP5:                                      -                                                                                                               


    ECgene alternative splicing isoforms for CDH5

    Expression
    for CDH5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDH5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGCTCCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDH5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Blood IslandsExtraembryonic AngioblastsEndothelium
    HeartEndocardiumEndocardial CellsEndocardium
    Lateral Plate MesodermEmbryonic Blood IslandsAngioblastsEndothelium
    Lateral Plate MesodermEmbryonic Capillary PlexusAngioblastsEndothelium
    Lateral Plate MesodermPaired Dorsal AortaArterial endothelial cellsEndothelium
    Lateral Plate MesodermProepicardiumAngioblastsEndothelium
    Yolk SacDefinitive Yolk SacDefinitive Hematopoietic Stem CellsBlood
    EndotheliumMicrovesselsPericytesPericytes
    Primitive StreakPosterior Primitive StreakHemangioblastsBlood, Endothelium
    Umbilical CordUmbilical VeinsUmbilical vein endothelial cellsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/25 LifeMap Cells (see all 25) 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Hematopoietic progenitor cells (Generation of hemato...)
    Endothelial-like cells (Generation of hemato...)
    Brain microvascular endothelial cells (Derivation of blood-...)
    Endothelial-like cells (Derivation and purif...)
    Endothelial progenitor cells (Derivation and purif...)

    See CDH5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDH5

    SOURCE GeneReport for Unigene cluster: Hs.76206

    UniProtKB/Swiss-Prot: CADH5_HUMAN, P33151
    Tissue specificity: Endothelial tissues and brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDH5 (see all 8): 
              Terminal Differentiation Markers in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Angiogenesis in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for CDH5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CDH5 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDH51 cadherin 5, type 2 (vascular endothelium) 61(n)
    58.91(a)    		   374068  NM_204227.1  NP_989558.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CDH56
    		 --
    		 54(a)
    		 1 ↔ 1
    		 LGc(9437527-9460704)
    zebrafish
    (Danio rerio)    		 Actinopterygii cdh51 cadherin 5 50.57(n)
    42.45(a)    		   445471  NM_001003983.1  NP_001003983.1 


    ENSEMBL Gene Tree for CDH5 (if available)
    TreeFam Gene Tree for CDH5 (if available) 

    Paralogs
    for CDH5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDH5 gene
    CDH42  CDH182  DSG42  CDH32  CDH102  CDH112  CDH12  CDH62  
    DSC22  CDH82  CDH202  CDH222  DSC12  CDH192  DSG12  CDH72  
    DSG22  CDH92  CDH122  CDH262  DSC32  CDH22  CDH242  CDH152  
    DSG32  
    17 SIMAP similar genes for CDH5 using alignment to 10 protein entries:     CADH5_HUMAN (see all proteins):
    Nbla04261    CDH17    FAT3    CDH18    CDH10    CDH9
    CDH7    CDH8    CDH15    CDH4    CDH19    CDH20
    CDH6    CDH24    CDH11    DSC2    CDH3

    CDH5 for paralogs           About GeneDecksing



    Genomic Variants
    for CDH5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/691 NCBI SNPs in CDH5 are shown (see all 691)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs38096481,2
    		C,F,H,--66398525(-) GCCTGT/CGCATT 1 -- us2k121Minor allele frequency- C:0.25NA NS EA CSA WA 2259
    rs1450532731,2
    		C,--66398639(+) AACCCC/TCCCTC 1 -- us2k10--------
    rs99398681,2
    		C,F,H,--66398641(+) NNNNCA/C/TCTCTG 1 -- us2k1 trp39NS EA WA NA CSA 540
    rs1491201541,2
    		--66398642(+) CCCCCC/GTCTGG 1 -- us2k10--------
    rs798256481,2
    		--66398685(+) AGGAAG/TCGCTG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs671473251,2
    		C,F,--66398766(+) ACTGTT/CCTCCT 1 -- us2k18Minor allele frequency- C:0.37WA NA CSA EA 368
    rs1431189441,2
    		--66398805(+) ATCATC/TTGTCT 1 -- us2k10--------
    rs99401661,2
    		C,F,--66398845(+) TGAGCG/ATGCTG 1 -- us2k12Minor allele frequency- A:0.11WA NA 238
    rs99400441,2
    		C,F,A,H,--66398933(+) GGAAGA/GAGCTA 1 -- us2k1 trp324Minor allele frequency- G:0.21NS EA NA WA CSA 2752
    rs348475731,2
    		C,--66399302(+) CACCCCT/-GTCTC 1 -- us2k11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for CDH5 (66400525 - 66438689 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CDH5
         2 CNVs: 4962 102313
         1 Indel: 42798
    Human Gene Mutation Database (HGMD): CDH5

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CDH5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDH5 for disorders           About GeneDecksing

    OMIM gene information: 601120    OMIM disorders: --

    20/50 diseases for CDH5 (see all 50):    About MalaCards
    prostate cancer    periapical granuloma    prostatitis    myocardial infarction
    abdominal aortic aneurysm    acute myocardial infarction    aortic aneurysm    perineurioma
    angiosarcoma    hereditary angioedema    ovarian hyperstimulation syndrome    diabetic retinopathy
    angioedema    angiosarcoma of the scalp    epithelioid sarcoma    corneal dystrophy
    pancreatic endocrine tumors    acute lymphoblastic leukemia    dilated cardiomyopathy    multiple sclerosis

    2 diseases from the University of Copenhagen DISEASES database for CDH5:
    Vascular disease     Cancer

    10/34 Novoseek disease relationships for CDH5 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 63.6 7 10615428 (2), 11980651 (1), 14695457 (1), 11238107 (1) (see all 5)
    mimicry 60.6 11 11416160 (2), 12941789 (1), 19760520 (1), 17456780 (1) (see all 9)
    uveal melanoma 52 4 19735546 (1), 18477893 (1), 19043732 (1)
    perineurioma 39.3 1 12786903 (1)
    tumors 37 63 18316602 (5), 11980651 (3), 17060772 (3), 9840805 (2) (see all 36)
    melanoma 32.1 25 9415377 (5), 20181932 (4), 16481735 (2), 11416160 (2) (see all 10)
    necrosis 27.3 12 17060772 (2), 16775665 (2), 12888895 (1), 11733377 (1) (see all 10)
    sarcoma epithelioid 27.3 5 9839166 (2), 16324194 (2)
    acute myocardial infarction 26.3 4 19519369 (3), 14695457 (1)
    metastasis 20.7 2 11156369 (1), 17456780 (1)

    Human Genome Epidemiology (HuGE) Navigator: CDH5 (3 documents)

    Export disorders for CDH5 gene to outside databases

    Publications
    for CDH5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDH5 gene, integrated from 9 sources (see all 543):
    (articles sorted by number of sources associating them with CDH5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PubMed id 2059658)1, 2, 3 Suzuki S....Tanihara H. (1991)
    2. Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. (PubMed id 7627717)1, 2, 9 Breviario F.... Dejana E. (1995)
    3. Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. (PubMed id 9219219)1, 2, 9 Ali J.... Muller W.A. (1997)
    4. Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. (PubMed id 19996314)1, 2 Graziani A.... Groschner K. (2010)
    5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    6. Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. (PubMed id 10861224)1, 2 Shimoyama Y.... Natori M. (2000)
    7. A novel endothelial-specific membrane protein is a marker of cell- cell contacts. (PubMed id 1522121)1, 2 Lampugnani M.G.... Dejana E. (1992)
    8. A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor. (PubMed id 18180305)1, 9 Ha C.H....Jin Z.G. (2008)
    9. Mechanisms of VE-cadherin processing and degradation in microvascular endothelial cells. (PubMed id 12626512)1, 9 Xiao K....Kowalczyk A.P. (2003)
    10. An immunohistochemical study of cadherin 5 (VE-cadherin) in vascular endothelial cells in placentas with gestosis. (PubMed id 10063232)1, 9 Kawashima M. and Kitagawa M. (1998)

    External Searches for CDH5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDH5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1003 HGNC: 1764 AceView: CDH5 Ensembl:ENSG00000179776 euGenes: HUgn1003
    ECgene: CDH5 Kegg: 1003 H-InvDB: CDH5

    Other Databases showing CDH5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDH5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDH5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDH5 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CDH5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDH5 gene:
    Search GeneIP for patents involving CDH5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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