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CDH5 Gene

protein-coding   GIFtS: 72
GCID: GC16P066400

Cadherin 5, Type 2 (Vascular Endothelium)

(Previous names: cadherin 5, type 2, VE-cadherin (vascular epithelium))
  See CDH5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cadherin 5, Type 2 (Vascular Endothelium)1 2     7B4 Antigen2 3
VE-cadherin1 2 3     7B42
Cadherin 5, Type 2, VE-Cadherin (Vascular Epithelium)1 2     CD1442
CD144 Antigen2 3     cadherin-52
Vascular Endothelial Cadherin2 3     Endothelial-Specific Cadherin2

External Ids:    HGNC: 17641   Entrez Gene: 10032   Ensembl: ENSG000001797767   OMIM: 6011205   UniProtKB: P331513   

Export aliases for CDH5 gene to outside databases

Previous GC identifers: GC16P056984 GC16P066658 GC16P066136 GC16P066176 GC16P064958 GC16P052277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDH5 Gene:
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a
region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate
cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five
extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a
classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an
important role in endothelial cell biology through control of the cohesion and organization of the intercellular
junctions. An alternative splice variant has been described but its full length sequence has not been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CDH5 Gene:
CDH5 (cadherin 5, type 2 (vascular endothelium)) is a protein-coding gene. Diseases associated with CDH5 include angiosarcoma of the scalp, and angiosarcoma. GO annotations related to this gene include ion channel binding and calcium ion binding. An important paralog of this gene is CDH18.

UniProtKB/Swiss-Prot: CADH5_HUMAN, P33151
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell
types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and
organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.
Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These
effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation
of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction

Gene Wiki entry for CDH5 (VE-cadherin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDH5 gene promoter:
         AML1a   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDH5 promoter sequence
   Search Chromatin IP Primers for CDH5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDH5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q22.1

CDH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066400:  view genomic region     (about GC identifiers)

Start:
66,400,525 bp from pter      End:
66,438,689 bp from pter
Size:
38,165 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CADH5_HUMAN, P33151 (See protein sequence)
Recommended Name: Cadherin-5 precursor  
Size: 784 amino acids; 87528 Da
Subunit: Interacts (via cadherin 5 domain) with PTPRB (By similarity). Interacts with TRPC4. Interacts with KRIT1.
Interacts with PARD3 (By similarity)
Secondary accessions: Q4VAI5 Q4VAI6
Alternative splicing: 2 isoforms:  P33151-1   P33151-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDH5: NX_P33151

Explore proteomics data for CDH5 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity)1
  • O-glycosylated1
  • Glycosylation2 at Asn61, Asn112, Asn157, Asn362, Asn442, Asn523, Asn535
  • Modification sites at PhosphoSitePlus

  • See CDH5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001786.2  
    ENSEMBL proteins: 
     ENSP00000344115   ENSP00000456028   ENSP00000455302   ENSP00000456093   ENSP00000455655  
     ENSP00000458878   ENSP00000461880  
    Reactome Protein details: P33151

    CDH5 Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for CDH5 (VE-Cadherin)
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CDH5
    GenScript Custom Purified and Recombinant Proteins Services for CDH5
    Novus Biologicals CDH5 Protein
    Sino Biological Recombinant Protein for CDH5
    Sino Biological Cell Lysate for CDH5
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDH5

     
    Search eBioscience for Proteins for CDH5 

    CDH5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDH5
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    LSBio Antibodies in human, mouse, rat for CDH5

    CDH5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CDH5 (VE-Cadherin)         (see all)
    GenScript Custom Assay Services for CDH5
    Enzo Life Sciences assays for CDH5
    Cloud-Clone Corp. ELISAs for CDH5
    Cloud-Clone Corp. CLIAs for CDH5
    eBioscience ELISAs for CDH5: (see all 3
                        Human sVE-cadherin Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MCDH: Cadherins / Major cadherins
    CD: CD molecules

    5 InterPro protein domains:
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR027397 Catenin_binding_dom
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry P33151

    ProtoNet protein and cluster: P33151

    2 Blocks protein domains:
    IPB000233 Cadherin cytoplasmic region
    IPB002126 Cadherin


    UniProtKB/Swiss-Prot: CADH5_HUMAN, P33151
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the
    connections, imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 5 cadherin domains


    Find genes that share domains with CDH5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CADH5_HUMAN, P33151
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
    a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell
    types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and
    organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.
    Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These
    effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation
    of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction

         Genatlas biochemistry entry for CDH5:
    cadherin 5,VE-cadherin,transmembrane glycoprotein component of adherens junction,expressed in vascular
    endothelium,integrity and normal organ function required for vascular

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI12088286
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI17057644
    GO:0008013beta-catenin binding IPI18287330
    GO:0019903protein phosphatase binding IEA--
         
    Find genes that share ontologies with CDH5           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CDH5:
     Decreased viability with carbo  Decreased viability with pacli  Synthetic lethal with Ras 

         11 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Cdh5):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size/body 
     hematopoietic system  immune system  integument  mortality/aging  normal 
     vision/eye 

    Find genes that share phenotypes with CDH5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CDH5: Cdh5tm2Pec Cdh5tm1Pec Cdh5tm1Hub Cdh5tm1.1Pec

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDH5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDH5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDH5

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDH5:
    hsa-mir-26b-5p (MIRT029178), hsa-mir-211-5p (MIRT006257), hsa-mir-335-5p (MIRT017265), hsa-mir-128-3p (MIRT021947)

    Block miRNA regulation of human, mouse, rat CDH5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDH5 (see all 26):
    hsa-miR-576-3p hsa-miR-125a-5p hsa-miR-513a-5p hsa-miR-767-5p hsa-miR-128 hsa-miR-501-3p hsa-miR-502-3p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidCDH5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDH5

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CDH5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDH5 (NM_001795)
    Sino Biological Human cDNA Clone for CDH5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH5

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA4-10782) for CDH5 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CADH5_HUMAN, P33151: Cell junction. Cell membrane; Single-pass type I membrane protein (Probable). Note=Found at
    cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their
    localization to endothelial cell-cell junctions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton3
    extracellular2
    endoplasmic reticulum1
    lysosome1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction IDA19996314
    GO:0005923tight junction IEA--
    GO:0016020membrane TAS9219219
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CDH5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDH5 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Adherens junctions interactions0.49
    2ERK Signaling
    Rho Family GTPases0.61
    ILK Signaling0.49
    3Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    4Non-Canonical Wnt Pathway
    Canonical Wnt Pathway0.53
    5S1P3 pathway
    S1P2 pathway0.44


    Find genes that share SuperPaths with CDH5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CDH5
        VEGF - VEGF R2 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDH5 (see all 8)
        S-1P Stimulated Signaling
    G12-G13 in Cellular Signaling
    Transendothelial Migration of Leukocytes
    ILK Signaling
    GSK3 Signaling

    2 Cell Signaling Technology (CST) Pathways for CDH5
        Angiogenesis
    Adhesion

    2 GeneGo (Thomson Reuters) Pathways for CDH5
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Cadherin-mediated cell adhesion

    2 BioSystems Pathways for CDH5
        Signaling events mediated by VEGFR1 and VEGFR2
    S1P2 pathway

    1 Sino Biological Pathway for CDH5
        Canonical Wnt Pathway

    1 Reactome Pathway for CDH5
        Adherens junctions interactions


    2 Kegg Pathways  (Kegg details for CDH5):
        Cell adhesion molecules (CAMs)
    Leukocyte transendothelial migration

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDH5 (see all 8): 
              Terminal Differentiation Markers in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDH5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDH5 (P331511, 2, 3 ENSP000003441154) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW01, 2, 3, ENSP000003639214EBI-2903122,EBI-81968 MINT-4085723 MINT-4085234 MINT-4085272 MINT-4085739 MINT-4085197 MINT-4085447 I2D: score=2 STRING: ENSP00000363921
    CTNNA1P352212, 3, ENSP000003046694MINT-4085212 I2D: score=2 STRING: ENSP00000304669
    PARD6AQ9NPB61, 2, 3, ENSP000002192554EBI-2903122,EBI-81876 MINT-4085643 MINT-4085515 MINT-4085595 MINT-4085759 I2D: score=3 STRING: ENSP00000219255
    CTNNB1P352221, 2, 3, ENSP000003444564EBI-2903122,EBI-491549 MINT-4085223 MINT-4085471 I2D: score=6 STRING: ENSP00000344456
    SHC1P293532, 3, ENSP000004013034MINT-49635 MINT-49636 I2D: score=3 STRING: ENSP00000401303
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001955blood vessel maturation IEA--
    GO:0007156homophilic cell adhesion IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0034329cell junction assembly TAS--
    GO:0034332adherens junction organization TAS--

    Find genes that share ontologies with CDH5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDH5 (CADH5)

    1 HMDB Compound for CDH5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for CDH5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LenalidomideCC-5013 (see all 4)191732-72-6targetantagonist18805433

    Selected Novoseek inferred chemical compound relationships for CDH5 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 72.1 117 16683386 (6), 15708125 (5), 18180305 (5), 18780647 (4) (see all 52)
    matrigel 71.5 8 17569886 (1), 19760520 (1), 15370292 (1), 15735710 (1) (see all 8)
    tyrosine 52.9 96 10681592 (4), 12234928 (4), 12219009 (4), 16909109 (3) (see all 44)
    phosphotyrosine 34 3 19715693 (1), 9378757 (1)
    cytochalasin d 25.9 1 9120301 (1)
    dextran 23.3 1 19944695 (1)
    phosphoinositide 23 1 16962712 (1)
    histamine 21.4 23 15220112 (5), 18287330 (5), 12003790 (4), 10521356 (3) (see all 6)
    nitric oxide 19.1 12 19037921 (2), 16574915 (1), 19563553 (1), 16507070 (1) (see all 9)
    forskolin 11.6 13 20032304 (4), 15475517 (2), 19789809 (1)



    Find genes that share compounds with CDH5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDH5 gene (2 alternative transcripts): 
    NM_001795.3  NM_001114117.1  

    Unigene Cluster for CDH5:

    Cadherin 5, type 2 (vascular endothelium)
    Hs.76206  [show with all ESTs]
    Unigene Representative Sequence: NM_001795
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341529(uc002eom.4) ENST00000565334 ENST00000562048 ENST00000568155
    ENST00000568023 ENST00000563425(uc002eon.1) ENST00000539168
    miRNA
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    hsa-miR-576-3p hsa-miR-125a-5p hsa-miR-513a-5p hsa-miR-767-5p hsa-miR-128 hsa-miR-501-3p hsa-miR-502-3p hsa-miR-144
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDH5
    Clone
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    GenScript: all cDNA clones in your preferred vector: CDH5 (NM_001795)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH5
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDH5
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      QuantiFast Probe-based Assays in human, mouse, rat CDH5
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA4-10782) for CDH5 

    Additional mRNA sequence: 

    AB035304.1 AB209908.1 AK300299.1 AK300322.1 AK300461.1 BC096363.3 BC096364.3 BC096365.1 
    BC117520.2 U84722.1 X59796.1 X79981.1 

    10 DOTS entries:

    DT.415056  DT.120691480  DT.40279949  DT.92423053  DT.95165092  DT.40221688  DT.92041742  DT.92423051 
    DT.95165089  DT.95165090 

    Selected AceView cDNA sequences (see all 101):

    BP362670 AA181178 BM710619 AA368240 AL546985 R63469 BU616085 AA903073 
    AI360970 BQ716387 AW104445 AI362402 CR604654 BQ022023 AA346693 CR595820 
    AI801770 BU732589 NM_001795 N22448 CA425506 AL048265 AL039312 BQ022882 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDH5 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:                          -     -     -                                                                                                               
    SP2:                          -     -     -                                                                       -     -     -                           
    SP3:                          -     -     -                                                                                                               
    SP4:                                -     -                                                                                                               
    SP5:                                      -                                                                                                               


    ECgene alternative splicing isoforms for CDH5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDH5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGCTCCTG
    CDH5 Expression
    About this image


    CDH5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 27) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 46 entries
             Extraembryonic Angioblasts Extraembryonic Blood Islands
             Peripheral blood endothelial colony-forming cells
             Brain microvascular endothelial cells
             Human Aortic Endothelial Cells (HAEC)   
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
             Angiogenic cell precursor
             Hematopoietic progenitor cells
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 4 entries
             Arterial Endothelial Cells Paired Dorsal Aorta
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Brain microvascular endothelial cells
             Human Brain Microvascular Endothelial Cells (HBMEC)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 5 entries
             Umbilical vein endothelial cells Umbilical Veins
             Wharton's jelly-derived stem cells
             Human Umbilical Artery Endothelial Cells (HUAEC)   
    CDH5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDH5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76206

    UniProtKB/Swiss-Prot: CADH5_HUMAN, P33151
    Tissue specificity: Endothelial tissues and brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDH5 (see all 8): 
              Terminal Differentiation Markers in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Angiogenesis in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDH5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdh51 , 5 cadherin 51, 5 80.11(n)1
    75.67(a)1
      8 (53.04 cM)5
    125621  NM_009868.41  NP_033998.21 
     1041016255 
    chicken
    (Gallus gallus)
    Aves CDH51 cadherin 5, type 2 (vascular endothelium) 61.17(n)
    59.26(a)
      374068  NM_204227.1  NP_989558.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDH56
    cadherin 5, type 2 (vascular endothelium)
    54(a)
    1 ↔ 1
    LGc(9415737-9460704)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdh51 cadherin 5, type 2 (vascular endothelium) 57.89(n)
    56.89(a)
      100488458  XM_002933672.2  XP_002933718.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cdh51 cadherin 5 50.96(n)
    43.3(a)
      445471  NM_001003983.1  NP_001003983.1 


    ENSEMBL Gene Tree for CDH5 (if available)
    TreeFam Gene Tree for CDH5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDH5 gene
    CDH182  CDH222  CDH192  CDH102  CDH112  CDH72  CDH92  CDH62  
    CDH122  CDH82  CDH242  CDH202  
    Selected SIMAP similar genes for CDH5 using alignment to 8 protein entries:     CADH5_HUMAN (see all proteins) (see all similar genes):
    Nbla04261    CDH17    CDH9    CDH18    CDH10    CDH6
    FAT3    CDH7    CDH8    CDH11    CDH20    CDH24
    CDH1    CDH15    CDH4    CDH19    DSC2    CDH2

    Find genes that share paralogs with CDH5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDH5 (see all 877)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38096481,2
    C,F,H--66398525(-) GCCTGT/CGCATT 1 -- us2k121Minor allele frequency- C:0.25NA NS EA CSA WA 2259
    rs1450532731,2
    C--66398639(+) AACCCC/TCCCTC 1 -- us2k10--------
    rs99398681,2
    C,F,H--66398641(+) CCCCCA/C/TCTCTG 1 -- us2k1 trp39NS EA WA NA CSA 540
    rs1491201541,2
    --66398642(+) CCCCCC/GTCTGG 1 -- us2k10--------
    rs798256481,2
    F--66398685(+) AGGAAG/TCGCTG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs671473251,2
    C,F--66398766(+) ACTGTT/CCTCCT 1 -- us2k18Minor allele frequency- C:0.37WA NA CSA EA 368
    rs1431189441,2
    --66398805(+) ATCATC/TTGTCT 1 -- us2k10--------
    rs99401661,2
    C,F--66398845(+) tgagcG/Atgctg 1 -- us2k12Minor allele frequency- A:0.11WA NA 238
    rs99400441,2
    C,F,A,H--66398933(+) ggaagA/Gagcta 1 -- us2k1 trp324Minor allele frequency- G:0.21NS EA NA WA CSA 2752
    rs348475731,2
    C--66399302(+) CACCCCT/-GTCTC 1 -- us2k11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for CDH5 (66400525 - 66438689 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CDH5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2468646CNV Deletion19546169
    esv4828CNV Deletion18987735
    esv2714643CNV Deletion23290073
    esv2714642CNV Deletion23290073
    nsv833264CNV Gain17160897
    nsv906784CNV Gain21882294

    Human Gene Mutation Database (HGMD): CDH5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDH5
    DNA2.0 Custom Variant and Variant Library Synthesis for CDH5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601120    OMIM disorders: --

    7 diseases for CDH5:    
    About MalaCards
    angiosarcoma of the scalp    angiosarcoma    epithelioid sarcoma    perineurioma
    periapical granuloma    prostate cancer    myocardial infarction

    2 diseases from the University of Copenhagen DISEASES database for CDH5:
    Vascular disease     Cancer

    Find genes that share disorders with CDH5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CDH5 gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 63.6 7 10615428 (2), 11980651 (1), 14695457 (1), 11238107 (1) (see all 5)
    mimicry 60.6 11 11416160 (2), 12941789 (1), 19760520 (1), 17456780 (1) (see all 9)
    uveal melanoma 52 4 19735546 (1), 18477893 (1), 19043732 (1)
    perineurioma 39.3 1 12786903 (1)
    tumors 37 63 18316602 (5), 11980651 (3), 17060772 (3), 9840805 (2) (see all 36)
    melanoma 32.1 25 9415377 (5), 20181932 (4), 16481735 (2), 11416160 (2) (see all 10)
    necrosis 27.3 12 17060772 (2), 16775665 (2), 12888895 (1), 11733377 (1) (see all 10)
    sarcoma epithelioid 27.3 5 9839166 (2), 16324194 (2)
    acute myocardial infarction 26.3 4 19519369 (3), 14695457 (1)
    metastasis 20.7 2 11156369 (1), 17456780 (1)

    Genetic Association Database (GAD): CDH5
    Human Genome Epidemiology (HuGE) Navigator: CDH5 (3 documents)

    Export disorders for CDH5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDH5 gene, integrated from 10 sources (see all 561):
    (articles sorted by number of sources associating them with CDH5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PubMed id 2059658)1, 2, 3 Suzuki S.... Tanihara H. (Cell Regul. 1991)
    2. Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. (PubMed id 7627717)1, 2, 9 Breviario F.... Dejana E. (Arterioscler. Thromb. Vasc. Biol. 1995)
    3. Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. (PubMed id 9219219)1, 2, 9 Ali J.... Muller W.A. (Microcirculation 1997)
    4. Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction. (PubMed id 19996314)1, 2 Graziani A.... Groschner K. (J. Biol. Chem. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    7. Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. (PubMed id 10861224)1, 2 Shimoyama Y.... Natori M. (Biochem. J. 2000)
    8. A novel endothelial-specific membrane protein is a marker of cell- cell contacts. (PubMed id 1522121)1, 2 Lampugnani M.G.... Dejana E. (J. Cell Biol. 1992)
    9. A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor. (PubMed id 18180305)1, 9 Ha C.H....Jin Z.G. (J. Biol. Chem. 2008)
    10. Mechanisms of VE-cadherin processing and degradation in microvascular endothelial cells. (PubMed id 12626512)1, 9 Xiao K....Kowalczyk A.P. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1003 HGNC: 1764 AceView: CDH5 Ensembl:ENSG00000179776 euGenes: HUgn1003
    ECgene: CDH5 Kegg: 1003 H-InvDB: CDH5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDH5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDH5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDH5 gene:
    Search GeneIP for patents involving CDH5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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