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Aliases for CDH5 Gene

Aliases for CDH5 Gene

  • Cadherin 5, Type 2 (Vascular Endothelium) 2 3
  • VE-Cadherin 2 3 4
  • Cadherin 5, Type 2, VE-Cadherin (Vascular Epithelium) 2 3
  • Vascular Endothelial Cadherin 3 4
  • 7B4 Antigen 3 4
  • Endothelial-Specific Cadherin 3
  • Cd144 Antigen 3
  • CD144 Antigen 4
  • Cadherin-5 3
  • CD144 3
  • 7B4 3

External Ids for CDH5 Gene

Previous GeneCards Identifiers for CDH5 Gene

  • GC16P056984
  • GC16P066658
  • GC16P066136
  • GC16P066176
  • GC16P064958
  • GC16P066400
  • GC16P052277

Summaries for CDH5 Gene

Entrez Gene Summary for CDH5 Gene

  • This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH5 Gene

CDH5 (Cadherin 5, Type 2 (Vascular Endothelium)) is a Protein Coding gene. Diseases associated with CDH5 include angiosarcoma of the scalp and angiosarcoma. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include calcium ion binding and ion channel binding. An important paralog of this gene is CDH19.

UniProtKB/Swiss-Prot for CDH5 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

Gene Wiki entry for CDH5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH5 Gene

Genomics for CDH5 Gene

Regulatory Elements for CDH5 Gene

Genomic Location for CDH5 Gene

Start:
66,366,622 bp from pter
End:
66,404,786 bp from pter
Size:
38,165 bases
Orientation:
Plus strand

Genomic View for CDH5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDH5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH5 Gene

Proteins for CDH5 Gene

  • Protein details for CDH5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33151-CADH5_HUMAN
    Recommended name:
    Cadherin-5
    Protein Accession:
    P33151
    Secondary Accessions:
    • Q4VAI5
    • Q4VAI6

    Protein attributes for CDH5 Gene

    Size:
    784 amino acids
    Molecular mass:
    87528 Da
    Quaternary structure:
    • Interacts (via cadherin 5 domain) with PTPRB (By similarity). Interacts with TRPC4. Interacts with KRIT1. Interacts with PARD3 (By similarity).

    Alternative splice isoforms for CDH5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH5 Gene

Proteomics data for CDH5 Gene at MOPED

Post-translational modifications for CDH5 Gene

  • O-glycosylated.
  • Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity).
  • Glycosylation at Asn61, Asn112, Asn157, Asn362, Asn442, Asn523, and Asn535
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH5 Gene

No data available for DME Specific Peptides for CDH5 Gene

Domains for CDH5 Gene

Gene Families for CDH5 Gene

HGNC:
  • CD :CD molecules
  • MCDH :Cadherins / Major cadherins

Graphical View of Domain Structure for InterPro Entry

P33151

UniProtKB/Swiss-Prot:

CADH5_HUMAN :
  • P33151
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH5: view

Function for CDH5 Gene

Molecular function for CDH5 Gene

GENATLAS Biochemistry: cadherin 5,VE-cadherin,transmembrane glycoprotein component of adherens junction,expressed in vascular endothelium,integrity and normal organ function required for vascular
UniProtKB/Swiss-Prot Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

Gene Ontology (GO) - Molecular Function for CDH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 12088286
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 17057644
GO:0008013 beta-catenin binding IPI 18287330
GO:0019903 protein phosphatase binding IEA --
genes like me logo Genes that share ontologies with CDH5: view
genes like me logo Genes that share phenotypes with CDH5: view

Animal Models for CDH5 Gene

MGI Knock Outs for CDH5:

miRNA for CDH5 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CDH5 Gene

Localization for CDH5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH5 Gene

Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH5 Gene COMPARTMENTS Subcellular localization image for CDH5 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CDH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IDA 19996314
GO:0005912 adherens junction IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016020 membrane TAS 9219219
genes like me logo Genes that share ontologies with CDH5: view

Pathways for CDH5 Gene

genes like me logo Genes that share pathways with CDH5: view

Pathways by source for CDH5 Gene

Gene Ontology (GO) - Biological Process for CDH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001955 blood vessel maturation IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0034329 cell junction assembly TAS --
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CDH5: view

Compounds for CDH5 Gene

(1) HMDB Compounds for CDH5 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for CDH5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Lenalidomide
  • CC-5013
191732-72-6 target antagonist

(30) Novoseek inferred chemical compound relationships for CDH5 Gene

Compound -log(P) Hits PubMed IDs
vegf 72.1 86
matrigel 71.5 8
tyrosine 52.9 68
phosphotyrosine 34 2
cytochalasin d 25.9 1
genes like me logo Genes that share compounds with CDH5: view

Transcripts for CDH5 Gene

Unigene Clusters for CDH5 Gene

Cadherin 5, type 2 (vascular endothelium):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for CDH5 Gene

GeneLoc Exon Structure for
CDH5
ECgene alternative splicing isoforms for
CDH5

Expression for CDH5 Gene

mRNA expression in normal human tissues for CDH5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH5 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.5) and Lung (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDH5 Gene

SOURCE GeneReport for Unigene cluster for CDH5 Gene Hs.76206

mRNA Expression by UniProt/SwissProt for CDH5 Gene

P33151-CADH5_HUMAN
Tissue specificity: Endothelial tissues and brain
genes like me logo Genes that share expressions with CDH5: view

Orthologs for CDH5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH5 35
  • 99.53 (n)
  • 99.74 (a)
CDH5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDH5 35
  • 83.5 (n)
  • 79.87 (a)
CDH5 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH5 35
  • 85.11 (n)
  • 80.78 (a)
CDH5 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh5 35
  • 80.11 (n)
  • 75.67 (a)
Cdh5 16
Cdh5 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDH5 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh5 35
  • 80.28 (n)
  • 77.78 (a)
chicken
(Gallus gallus)
Aves CDH5 35
  • 61.17 (n)
  • 59.26 (a)
CDH5 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH5 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh5 35
  • 57.89 (n)
  • 56.89 (a)
zebrafish
(Danio rerio)
Actinopterygii cdh5 35
  • 50.96 (n)
  • 43.3 (a)
cdh5 36
  • 40 (a)
OneToOne
Species with no ortholog for CDH5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH5 Gene

ENSEMBL:
Gene Tree for CDH5 (if available)
TreeFam:
Gene Tree for CDH5 (if available)

Paralogs for CDH5 Gene

Paralogs for CDH5 Gene

genes like me logo Genes that share paralogs with CDH5: view

Variants for CDH5 Gene

Sequence variations from dbSNP and Humsavar for CDH5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1049970 - 66,398,520(+) ATTCA(C/T)CTTGA missense, reference
rs1063438 -- 66,403,228(+) GTCAG(A/T)CGCCA utr-variant-3-prime
rs1063439 -- 66,403,230(+) CAGTC(G/T)CCAGG utr-variant-3-prime
rs1073584 -- 66,396,564(+) TCCAG(C/T)GAGCC intron-variant
rs1076019 -- 66,374,128(-) GCGTT(C/T)CCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH5 Gene

Variant ID Type Subtype PubMed ID
nsv833264 CNV Gain 17160897
nsv906784 CNV Gain 21882294
esv2468646 CNV Deletion 19546169
esv4828 CNV Deletion 18987735
esv2714642 CNV Deletion 23290073
esv2714643 CNV Deletion 23290073

Relevant External Links for CDH5 Gene

HapMap Linkage Disequilibrium report
CDH5
Human Gene Mutation Database (HGMD)
CDH5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH5 Gene

Disorders for CDH5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (8) Diseases for CDH5 Gene including...

Search for CDH5 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CDH5 Gene

(34) Novoseek inferred disease relationships for CDH5 Gene

Disease -log(P) Hits PubMed IDs
neovascularization 63.6 6
mimicry 60.6 10
uveal melanoma 52 3
perineurioma 39.3 1
tumors 37 46

Relevant External Links for CDH5

Genetic Association Database (GAD)
CDH5
Human Genome Epidemiology (HuGE) Navigator
CDH5
genes like me logo Genes that share disorders with CDH5: view

No data available for UniProtKB/Swiss-Prot for CDH5 Gene

Publications for CDH5 Gene

  1. Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. (PMID: 7627717) Breviario F. … Dejana E. (Arterioscler. Thromb. Vasc. Biol. 1995) 3 4 23
  2. Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion. (PMID: 9219219) Ali J. … Muller W.A. (Microcirculation 1997) 3 4 23
  3. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PMID: 2059658) Suzuki S. … Tanihara H. (Cell Regul. 1991) 2 3 4
  4. Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells. (PMID: 20032304) Noda K. … Mochizuki N. (Mol. Biol. Cell 2010) 3 23
  5. Src-induced tyrosine phosphorylation of VE-cadherin is not sufficient to decrease barrier function of endothelial monolayers. (PMID: 20048167) Adam A.P. … Vincent P.A. (J. Biol. Chem. 2010) 3 23

Products for CDH5 Gene

Sources for CDH5 Gene

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