Aliases for CDH5 Gene
External Ids for CDH5 Gene
Previous GeneCards Identifiers for CDH5 Gene
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDH5 Gene
CDH5 (Cadherin 5, Type 2 (Vascular Endothelium)) is a Protein Coding gene. Diseases associated with CDH5 include angiosarcoma of the scalp and angiosarcoma. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include calcium ion binding and ion channel binding. An important paralog of this gene is CDH19.
UniProtKB/Swiss-Prot for CDH5 Gene
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.