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Aliases for CDH5 Gene

Aliases for CDH5 Gene

  • Cadherin 5 2 3
  • Cadherin 5, Type 2 (Vascular Endothelium) 2 3 5
  • VE-Cadherin 2 3 4
  • Cadherin 5, Type 2, VE-Cadherin (Vascular Epithelium) 2 3
  • Vascular Endothelial Cadherin 3 4
  • 7B4 Antigen 3 4
  • Endothelial-Specific Cadherin 3
  • Cd144 Antigen 3
  • CD144 Antigen 4
  • CD144 3
  • 7B4 3

External Ids for CDH5 Gene

Previous GeneCards Identifiers for CDH5 Gene

  • GC16P056984
  • GC16P066658
  • GC16P066136
  • GC16P066176
  • GC16P064958
  • GC16P066400
  • GC16P052277

Summaries for CDH5 Gene

Entrez Gene Summary for CDH5 Gene

  • This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]

GeneCards Summary for CDH5 Gene

CDH5 (Cadherin 5) is a Protein Coding gene. Diseases associated with CDH5 include periapical granuloma and uveal melanoma. Among its related pathways are Signaling by GPCR and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. GO annotations related to this gene include calcium ion binding and ion channel binding. An important paralog of this gene is CDH19.

UniProtKB/Swiss-Prot for CDH5 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

Gene Wiki entry for CDH5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH5 Gene

Genomics for CDH5 Gene

Regulatory Elements for CDH5 Gene

Promoters for CDH5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDH5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDH5 Gene

Chromosome:
16
Start:
66,366,622 bp from pter
End:
66,404,786 bp from pter
Size:
38,165 bases
Orientation:
Plus strand

Genomic View for CDH5 Gene

Genes around CDH5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH5 Gene

Proteins for CDH5 Gene

  • Protein details for CDH5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33151-CADH5_HUMAN
    Recommended name:
    Cadherin-5
    Protein Accession:
    P33151
    Secondary Accessions:
    • Q4VAI5
    • Q4VAI6

    Protein attributes for CDH5 Gene

    Size:
    784 amino acids
    Molecular mass:
    87528 Da
    Quaternary structure:
    • Interacts (via cadherin 5 domain) with PTPRB (By similarity). Interacts with TRPC4. Interacts with KRIT1. Interacts with PARD3 (By similarity).

    Alternative splice isoforms for CDH5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH5 Gene

Proteomics data for CDH5 Gene at MOPED

Post-translational modifications for CDH5 Gene

  • O-glycosylated.
  • Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB (By similarity).
  • Glycosylation at Asn 61, Asn 112, Asn 157, Asn 362, Asn 442, Asn 523, and Asn 535
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDH5 (CDH5)

No data available for DME Specific Peptides for CDH5 Gene

Domains & Families for CDH5 Gene

Gene Families for CDH5 Gene

Graphical View of Domain Structure for InterPro Entry

P33151

UniProtKB/Swiss-Prot:

CADH5_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH5: view

Function for CDH5 Gene

Molecular function for CDH5 Gene

GENATLAS Biochemistry:
cadherin 5,VE-cadherin,transmembrane glycoprotein component of adherens junction,expressed in vascular endothelium,integrity and normal organ function required for vascular
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
genes like me logo Genes that share phenotypes with CDH5: view

Animal Models for CDH5 Gene

MGI Knock Outs for CDH5:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH5 Gene

Localization for CDH5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH5 Gene

Cell junction. Cell membrane; Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH5 Gene COMPARTMENTS Subcellular localization image for CDH5 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
extracellular 3
nucleus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CDH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005923 bicellular tight junction IEA --
genes like me logo Genes that share ontologies with CDH5: view

Pathways & Interactions for CDH5 Gene

genes like me logo Genes that share pathways with CDH5: view

SIGNOR curated interactions for CDH5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IEA --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0034332 adherens junction organization TAS --
GO:0045216 cell-cell junction organization TAS --
GO:1903142 positive regulation of establishment of endothelial barrier IMP 23288152
genes like me logo Genes that share ontologies with CDH5: view

Drugs & Compounds for CDH5 Gene

(15) Drugs for CDH5 Gene - From: Novoseek, ApexBio, DGIdb, DrugBank, FDA Approved Drugs, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lenalidomide Approved Pharma Target, antagonist Anti-angiogenic. 674
Revlimid Approved June 2013 Pharma 0
FX06 Investigational Pharma Target 0
calcium Nutra 0
Cadherin Peptide, avian Pharma Role in cell adhesion 0

(19) Additional Compounds for CDH5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CDH5 Gene

Compound Action Cas Number
Cadherin Peptide, avian Role in cell adhesion 127650-08-2
genes like me logo Genes that share compounds with CDH5: view

Transcripts for CDH5 Gene

Unigene Clusters for CDH5 Gene

Cadherin 5, type 2 (vascular endothelium):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for CDH5 Gene

GeneLoc Exon Structure for
CDH5
ECgene alternative splicing isoforms for
CDH5

Expression for CDH5 Gene

mRNA expression in normal human tissues for CDH5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH5 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.5) and Lung (x4.2).

Protein differential expression in normal tissues from HIPED for CDH5 Gene

This gene is overexpressed in Serum (53.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH5 Gene



SOURCE GeneReport for Unigene cluster for CDH5 Gene Hs.76206

mRNA Expression by UniProt/SwissProt for CDH5 Gene

P33151-CADH5_HUMAN
Tissue specificity: Endothelial tissues and brain.
genes like me logo Genes that share expression patterns with CDH5: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CDH5 Gene

Orthologs for CDH5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDH5 35
  • 83.5 (n)
  • 79.87 (a)
CDH5 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH5 35
  • 85.11 (n)
  • 80.78 (a)
CDH5 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh5 35
  • 80.11 (n)
  • 75.67 (a)
Cdh5 16
Cdh5 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDH5 35
  • 99.53 (n)
  • 99.74 (a)
CDH5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh5 35
  • 80.28 (n)
  • 77.78 (a)
oppossum
(Monodelphis domestica)
Mammalia CDH5 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH5 35
  • 61.17 (n)
  • 59.26 (a)
CDH5 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH5 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh5 35
  • 57.89 (n)
  • 56.89 (a)
zebrafish
(Danio rerio)
Actinopterygii cdh5 35
  • 50.96 (n)
  • 43.3 (a)
cdh5 36
  • 40 (a)
OneToOne
Species with no ortholog for CDH5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH5 Gene

ENSEMBL:
Gene Tree for CDH5 (if available)
TreeFam:
Gene Tree for CDH5 (if available)

Paralogs for CDH5 Gene

Paralogs for CDH5 Gene

genes like me logo Genes that share paralogs with CDH5: view

Variants for CDH5 Gene

Sequence variations from dbSNP and Humsavar for CDH5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs16956504 - 66,398,478(+) CGCAA(C/T)AGACA reference, missense
rs1049970 - 66,398,520(+) ATTCA(C/T)CTTGA reference, missense
rs1073584 -- 66,396,564(+) TCCAG(C/T)GAGCC intron-variant
rs1130844 -- 66,386,982(+) ACTGG(C/T)GAAAA reference, synonymous-codon
rs1063438 -- 66,403,228(+) GTCAG(A/T)CGCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDH5 Gene

Variant ID Type Subtype PubMed ID
nsv833264 CNV Gain 17160897
nsv906784 CNV Gain 21882294
esv2468646 CNV Deletion 19546169
esv4828 CNV Deletion 18987735
esv2714642 CNV Deletion 23290073
esv2714643 CNV Deletion 23290073

Variation tolerance for CDH5 Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.62; 56.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH5 Gene

HapMap Linkage Disequilibrium report
CDH5
Human Gene Mutation Database (HGMD)
CDH5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH5 Gene

Disorders for CDH5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CDH5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
periapical granuloma
  • apical granuloma
uveal melanoma
  • melanoma of uvea
perineurioma
  • soft tissue perineurioma
ovarian hyperstimulation syndrome
  • secondary meig's syndrome
microvascular complications of diabetes 5
  • diabetic nephropathy
- elite association - COSMIC cancer census association via MalaCards
Search CDH5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDH5

Genetic Association Database (GAD)
CDH5
Human Genome Epidemiology (HuGE) Navigator
CDH5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH5
genes like me logo Genes that share disorders with CDH5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH5 Gene

Publications for CDH5 Gene

  1. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PMID: 2059658) Suzuki S. … Tanihara H. (Cell Regul. 1991) 2 3 4 67
  2. The role of VE-cadherin in osteosarcoma cells. (PMID: 19760520) Zhang L.Z. … Huang W.D. (Pathol. Oncol. Res. 2010) 3 23
  3. Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells. (PMID: 20032304) Noda K. … Mochizuki N. (Mol. Biol. Cell 2010) 3 23
  4. Src-induced tyrosine phosphorylation of VE-cadherin is not sufficient to decrease barrier function of endothelial monolayers. (PMID: 20048167) Adam A.P. … Vincent P.A. (J. Biol. Chem. 2010) 3 23
  5. The motor protein myosin-X transports VE-cadherin along filopodia to allow the formation of early endothelial cell-cell contacts. (PMID: 20123970) Almagro S. … Gulino-Debrac D. (Mol. Cell. Biol. 2010) 3 23

Products for CDH5 Gene

Sources for CDH5 Gene

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