V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CDH3 Gene

protein-coding GIFtS: 63

GC16P067236

cadherin 3, type 1, P-cadherin (placental)
(Previous names: cadherin 3, P-cadherin (placental) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CDHP ^¹, ², ³, ⁵
HJMD ^², ⁵
P-cadherin ^³
PCAD ^¹, ², ⁵

Descriptions
Placental cadherin ^³
cadherin 3, P-cadherin (placental) ^¹
cadherin 3, type 1 ^²
cadherin 3, type 1, P-cadherin (placental) ^²
calcium-dependent adhesion protein, placental ^²

External Ids
HGNC: 1762¹
Entrez Gene: 1001²
UniProtKB: P22223³
Ensembl: ENSG00000062038⁷

Search outside databases for aliases for CDH3 gene

Previous GC identifers: GC16P059362 GC16P069056 GC16P068414 GC16P068454

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CDH3:

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a

calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin

repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a

six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of

heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this

protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with

congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq]

UniProtKB/Swiss-Prot: CADH3_HUMAN, P22223

Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with

themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the

sorting of heterogeneous cell types

Gene Wiki entry for CDH3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDH3 gene

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1

CDH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P067236: (about GC identifiers)

Start:	67,236,240 bp from pter
End:	67,290,443 bp from pter
Size:	54,204 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_010498.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CADH3_HUMAN, P22223 (See protein sequence)

Recommended Name: Cadherin-3 precursor

Size: 829 amino acids; 91418 Da

Subunit: Interacts with CDCP1

Subcellular location: Cell membrane; Single-pass type I membrane protein

Secondary accessions: Q05DI6

Alternative splicing: 2 isoforms: P22223-1 P22223-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001784.2

ENSEMBL proteins:

ENSP00000264012

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for CDH3 (P-Cadherin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (pan Cadherin, P cadherin)
	Human Recombinant Proteins from Abnova (CDH3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005913	cell-cell adherens junction	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for CDH3:

	Invitrogen Antibodies for CDH3
	Millipore Mono- and Polyclonal Antibodies for the study of CDH3
	Sigma-Aldrich Antibody Arrays and Antibodies for CDH3
	R&D Systems Antibodies for CDH3 (P-Cadherin)
	Cell Signaling Technology (CST) Antibodies for CDH3 (P-Cadherin, CadherinP)
	Antibodies from Abcam (pan Cadherin, P cadherin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CDH3)
	Novus Biologicals Antibodies for CDH3

Assays for CDH3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for CDH3 (P-Cadherin) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P22223

ProtoNet protein and cluster: P22223

2 Blocks protein families:

IPB000233 Cadherin cytoplasmic region

IPB002126 Cadherin

UniProtKB/Swiss-Prot: CADH3_HUMAN, P22223

Similarity: Contains 5 cadherin domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDH3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CDH3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001793

Applied Biosystems Silencer® siRNAs for CDH3

Sigma-Aldrich siRNA and siRNA Panels for CDH3

Sigma-Aldrich shRNA Panels and shRNA for CDH3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CDH3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001793
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001793
untagged cDNA clone in CMV expression vector: NM_001793

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001793

UniProtKB/Swiss-Prot: CADH3_HUMAN, P22223

Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with

themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the

sorting of heterogeneous cell types

Genatlas biochemistry entry for CDH3:

cadherin 3,P-cadherin,placental,transmembrane glycoprotein component of adherens junction,expressed

in placenta,forming a complex with the catenin that is loss in poorly differentiated esophageal

squamous carcinoma

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cdh3):

endocrine/exocrine gland

reproductive system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for CDH3 (Your Favorite Gene powered by Ingenuity)

Wnt/&beta

GeneDecks CDH3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CDH3

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007156	homophilic cell adhesion	IEA	--
GO:0007601	visual perception	IEA	--
GO:0050896	response to stimulus	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CDH3
4 Novoseek chemical compound relationships for CDH3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
progesterone	32.34	7	7534041 (1), 15933754 (1), 18811693 (1), 17146782 (1) (see all 7)
nitric oxide	4.93	2	14669304 (1), 16475686 (1)
calcium	1.47	23	9840799 (4), 9359492 (3), 10381572 (1), 9297684 (1) (see all 11)
tyrosine	0.00	2	9359492 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDH3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CDH3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001793

Sigma-Aldrich siRNA and siRNA Panels for CDH3

Sigma-Aldrich shRNA Panels and shRNA for CDH3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001793

REFSEQ mRNAs for CDH3 gene:

NM_001793.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001793

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001793
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001793
                                 untagged cDNA clone in CMV expression vector: NM_001793

Additional cDNA sequence:

AK225396.1 AK296968.1 AK312554.1 BC014462.1 BC041846.1 X63629.1

12 DOTS entries:

DT.113659 DT.100779495 DT.100779494 DT.91947365 DT.97780589 DT.120665526 DT.120665528 DT.120665631

DT.75102866 DT.92033387 DT.95080929 DT.95258646

24/160 AceView cDNA sequences (see all 160 ):

NM_001793 BQ928283 CA489338 AW473194 BM045728 CB996355 CA489124 CF593464

BG319601 BF915077 CA455046 C00249 BM766222 BQ676796 CB997053 BU543746

AL040609 CA454360 CB992509 BU168948 CA489357 BG538137 BM923882 BE378969

highest scoring ESTs for CDH3:

X63629 AA425217 AA535113 AA551779 AA551993 AA555159 AA632236 AA774611 AA836945 AI149268

Unigene Cluster for CDH3:

Cadherin 3, type 1, P-cadherin (placental)

Hs.191842 [show with all ESTs]

Unigene Representative Sequence: NM_001793

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CDH3

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14	^	15	^	16
SP1:																															-
SP2:					-
SP3:													-
SP4:							-
SP5:

About this scheme

ECgene alternative splicing isoforms for CDH3

1 Ensembl transcript including schematic representation:

ENST00000264012

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CDH3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDH3

¹ / ² / ³

4 probe-sets matching CDH3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
85838_r_at²^{, 3}	U95-E	1	1.00	1.00	-0.71	1.37	AI738412	0.20	1.00	0.72	1
160031_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.67	X63629	1.00	1.00	1.00	1
203256_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001793	0.60	1.00	0.82	1
203256_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CDH3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TACGGTGGCG

SOURCE GeneReport for Unigene cluster: Hs.191842
Expression variation in blood from EXPOLDB for CDH3
UniProtKB/Swiss-Prot: CADH3_HUMAN, P22223
Tissue specificity: Expressed in some normal epithelial tissues and in some carcinoma cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDH3 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDH3¹	--	cadherin 3, type 1, P-cadherin (placental)	86.23(n) 87.68(a)	611010 XM_848616.1 XP_853709.1
chimpanzee (Pan troglodytes)	CDH15¹	--	cadherin 15, type 1, M-cadherin (myotubule)	99.4(n) 99.4(a)	454192 XM_001167934.1 XP_001167934.1
cow (Bos taurus)	CDH3¹	--	cadherin 3, type 1, P-cadherin (placental)	83.88(n) 83.33(a)	281063 XM_614683.3 XP_614683.3
rat (Rattus norvegicus)	Cdh3¹	--	cadherin 3, type 1, P-cadherin (placental)	82.87(n) 84.25(a)	116777 XM_226426.4 XP_226426.4
mouse (Mus musculus)	Cdh3^{1, 5}	8 (53.30 cM)⁵	cadherin 3^{1, 5}	82.5(n)¹ 83.27(a)¹	12560¹ NM_001037809.2¹ NP_001032898.1¹ AI385538⁵ AK031265⁵ (see all 13)

About this table Species with no ortholog for CDH3

ENSEMBL Gene Tree for CDH3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDH3 gene

CDH1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/282 NCBI SNPs in CDH3 are shown (see all 282 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 103)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1126933^1,2	A,C,F,H,O	67279034(+)	`CGCCAC/GGTGCT`	1	Q/H	mis¹ ese³		18	MN EA NA EU WA	1670
	rs1886699^1,2	A,C,F,H,O	67289958(-)	`GAAGCA/CACCAC`	1	--	ut3¹ ese³		15	NA EU EA WA	1398
	rs3118235^1,2	A,C,F,H	67290478(-)	`TAAACC/TTTCTA`	1	--	ng3¹		4	EU EA WA	418
	rs1886701^1,2	F,H	67234433(-)	`AACGAG/TCAACT`	1	--	ng5¹		5	MN EU EA WA	598
	rs3785131^1,2	F,H	67234503(+)	`TGTGGG/AGATGC`	1	--	ng5¹		4	EU EA WA	418
--	rs9746680^1,2	H	67235949(+)	`ggtgaC/Gcctcc`	1	--	ut5¹		4	EU EA WA	400
	rs34494880^1,2	F	67276614(+)	`CTACCG/ACATCC`	1	H/R	mis¹		1	NA	76
	rs2296405^1,2	A,C,F,H,O	67278971(-)	`TGGTCA/GTTGAC`	1	N/N	syn¹		9	EA NA EU WA	2106
	rs2296409^1,2	A,C,F,H,O	67271231(-)	`TCATCT/CGTGGC`	1	T/T	syn¹		17	EA EU WA NA	2852
	rs2296408^1,2	A,C,F,H,O	67271324(-)	`TGAATG/TGTGAA`	1	T/T	syn¹ ese³		18	EA EU WA NA	2632

About this table

HapMap Linkage Disequilibrium images for CDH3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 114021 disorders: 601553 225280

UniProtKB/Swiss-Prot: CADH3_HUMAN, P22223

Defects in CDH3 are the cause of hypotrichosis with juvenile macular dystrophy (HJMD)

[MIM:601553]. HJMD is a rare autosomal recessive disorder characterized by early hair loss

heralding severe degenerative changes of the retinal macula and culminating in blindness during

the second to third decade of life

Defects in CDH3 are the cause of ectodermal dysplasia with ectrodactyly and macular

dystrophy (EEM) [MIM:225280]; also known as EEM syndrome, Albrectsen-Svendsen syndrome or

Ohdo-Hirayama-Terawaki syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders

due to abnormal development of two or more ectodermal structures. EEM is an autosomal recessive

condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp

hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly

10/56 Novoseek disease relationships for CDH3 gene (see all 56 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast carcinoma	68.94	30	10506713 (4), 14645693 (3), 12608656 (3), 16115928 (3) (see all 21)
carcinoma lobular	58.62	5	7534041 (1), 14645693 (1), 11921707 (1), 10506713 (1) (see all 5)
darier disease	57.99	3	11401672 (1), 15206690 (1)
carcinoma	55.79	29	14645693 (5), 7743525 (3), 9842964 (2), 10492037 (2) (see all 18)
carcinoma ductal	54.79	9	7534041 (2), 11942571 (2), 11454996 (1), 12608656 (1) (see all 7)
breast cancer	54.11	51	15930334 (7), 18811693 (5), 18001487 (4), 15548699 (3) (see all 24)
pemphigus vulgaris	48.37	1	10771476 (1)
hailey-hailey disease	47.84	1	11401672 (1)
tumors	47.43	74	15051772 (3), 16115928 (3), 16361544 (3), 8902651 (2) (see all 44)
carcinoma medullary	45.93	2	10492037 (2)

About this table

Human Gene Mutation Database: CDH3

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/247 PubMed articles for CDH3 gene (see all 247 ):

A missense mutation in CDH3, encoding P-cadherin, causes hypotrichosis with juvenile macular dystrophy. (PubMed id 12445216)^{1, 3, 4} Indelman M.... Sprecher E. (2002)
Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin. (PubMed id 11544476)^{1, 3, 4} Sprecher E....Szargel R. (2001)
P-cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer. (PubMed id 9815605)^{1, 3, 4} Jarrard D.F.... Isaacs W.B. (1997)
Adhesion signaling by a novel mitotic substrate of src kinases. (PubMed id 16007225)^{3, 4} Bhatt A.S.... Moasser M.M. (2005)
Distinct CDH3 mutations cause ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome). (PubMed id 15805154)^{3, 4} Kjaer K.W.... Rosenberg T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. (PubMed id 1427864)^{2, 3} Kaupmann K....Starzinski-Powitz A. (1992)
Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues. (PubMed id 2793940)^{3, 4} Shimoyama Y....Hirohashi S. (1989)
Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. (PubMed id 2702654)^{3, 4} Shimoyama Y.... Abe O. (1989)
P-cadherin expression and survival rate in oral squamous cell carcinoma: an immunohistochemical study. (PubMed id 15967043)^{1, 3} Lo Muzio L....Carinci F. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1001	HGNC: 1762	AceView: CDH3	Ensembl:ENSG00000062038	euGenes: HUgn1001
ECgene: CDH3	H-InvDB: CDH3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CDH3	Genetics and Cytogenetics in Oncology and Haematology
Mutations of the CDH3 gene	http://www.retina-international.com/sci-news/cdh3mut.htm
GeneReviews	http://www.genetests.org/query?gene=CDH3

Licensable Technologies for CDH3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CDH3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CDH3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CDH3		Antibodies for CDH3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CDH3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CDH3)
	Antibodies (CDH3)
	Chimera RNAi (CDH3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CDH3 (P-Cadherin, CadherinP)

	Recombinant Proteins (pan Cadherin, P cadherin)
	Antibodies (pan Cadherin, P cadherin)

Search OriGene for CDH3

Search Tocris compounds for CDH3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CDH3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CDH3 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

CDH3 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for CDH3

Summaries
for CDH3

Genomic Location
for CDH3

Proteins
for CDH3

Protein Domains/
Families
for CDH3

Gene Function
for CDH3

Pathways & Interactions
for CDH3

Drugs & Compounds
for CDH3

Transcripts
for CDH3

Expression
for CDH3

Orthologs
for CDH3

Paralogs
for CDH3

SNPs/Variants
for CDH3

Disorders & Mutations
for CDH3

Medical News
for CDH3

Publications
for CDH3

Search for CDH3

Genome Databases showing CDH3

Other Databases showing CDH3

Specialized Databases showing CDH3

Licensable Technologies
for CDH3

Services
for CDH3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDH3 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor CDH3

Summariesfor CDH3

Genomic Locationfor CDH3

Proteinsfor CDH3

Protein Domains/Familiesfor CDH3

Gene Functionfor CDH3

Pathways & Interactionsfor CDH3

Drugs & Compoundsfor CDH3

Transcriptsfor CDH3

Expression for CDH3

Orthologsfor CDH3

Paralogsfor CDH3

SNPs/Variantsfor CDH3

Disorders & Mutationsfor CDH3

Medical Newsfor CDH3

Publicationsfor CDH3

Search for CDH3

Genome Databases showing CDH3

Other Databases showing CDH3

Specialized Databases showing CDH3

Licensable Technologiesfor CDH3

Servicesfor CDH3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CDH3

Summaries
for CDH3

Genomic Location
for CDH3

Proteins
for CDH3

Protein Domains/
Families
for CDH3

Gene Function
for CDH3

Pathways & Interactions
for CDH3

Drugs & Compounds
for CDH3

Transcripts
for CDH3

Expression
for CDH3

Orthologs
for CDH3

Paralogs
for CDH3

SNPs/Variants
for CDH3

Disorders & Mutations
for CDH3

Medical News
for CDH3

Publications
for CDH3

Licensable Technologies
for CDH3

Services
for CDH3