Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDH3 Gene

Aliases for CDH3 Gene

  • Cadherin 3 2 3
  • Cadherin 3, Type 1, P-Cadherin (Placental) 2 3 5
  • CDHP 3 4
  • Calcium-Dependent Adhesion Protein, Placental 3
  • Cadherin 3, P-Cadherin (Placental) 2
  • Placental Cadherin 4
  • P-Cadherin 4
  • HJMD 3
  • PCAD 3

External Ids for CDH3 Gene

Previous GeneCards Identifiers for CDH3 Gene

  • GC16P059362
  • GC16P069056
  • GC16P068414
  • GC16P068454
  • GC16P067236
  • GC16P054551

Summaries for CDH3 Gene

Entrez Gene Summary for CDH3 Gene

  • This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015]

GeneCards Summary for CDH3 Gene

CDH3 (Cadherin 3) is a Protein Coding gene. Diseases associated with CDH3 include ectodermal dysplasia, ectrodactyly, and macular dystrophy and hypotrichosis, congenital, with juvenile macular dystrophy. Among its related pathways are ERK Signaling and Cell adhesion_Cadherin-mediated cell adhesion. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DSG2.

UniProtKB/Swiss-Prot for CDH3 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Wiki entry for CDH3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH3 Gene

Genomics for CDH3 Gene

Regulatory Elements for CDH3 Gene

Genomic Location for CDH3 Gene

Chromosome:
16
Start:
68,636,189 bp from pter
End:
68,727,577 bp from pter
Size:
91,389 bases
Orientation:
Plus strand

Genomic View for CDH3 Gene

Genes around CDH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH3 Gene

Proteins for CDH3 Gene

  • Protein details for CDH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22223-CADH3_HUMAN
    Recommended name:
    Cadherin-3
    Protein Accession:
    P22223
    Secondary Accessions:
    • B2R6F4
    • Q05DI6

    Protein attributes for CDH3 Gene

    Size:
    829 amino acids
    Molecular mass:
    91418 Da
    Quaternary structure:
    • Interacts with CDCP1 and CTNNB1.

    Three dimensional structures from OCA and Proteopedia for CDH3 Gene

    Alternative splice isoforms for CDH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH3 Gene

Proteomics data for CDH3 Gene at MOPED

Post-translational modifications for CDH3 Gene

  • Glycosylation at Asn 200 and Asn 566
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDH3 (CDH3)

No data available for DME Specific Peptides for CDH3 Gene

Domains & Families for CDH3 Gene

Gene Families for CDH3 Gene

Suggested Antigen Peptide Sequences for CDH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22223

UniProtKB/Swiss-Prot:

CADH3_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH3: view

Function for CDH3 Gene

Molecular function for CDH3 Gene

GENATLAS Biochemistry:
cadherin 3,P-cadherin,placental,transmembrane glycoprotein component of adherens junction,expressed in placenta,forming a complex with the catenin that is loss in poorly differentiated esophageal squamous carcinoma
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
genes like me logo Genes that share phenotypes with CDH3: view

Human Phenotype Ontology for CDH3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CDH3 Gene

MGI Knock Outs for CDH3:

Animal Model Products

miRNA for CDH3 Gene

miRTarBase miRNAs that target CDH3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for CDH3 Gene

Localization for CDH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH3 Gene COMPARTMENTS Subcellular localization image for CDH3 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CDH3 Gene

Pathways & Interactions for CDH3 Gene

genes like me logo Genes that share pathways with CDH3: view

Pathways by source for CDH3 Gene

Gene Ontology (GO) - Biological Process for CDH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,TAS 2793940
GO:0007601 visual perception IEA --
GO:0010628 positive regulation of gene expression IMP 23334344
GO:0010838 positive regulation of keratinocyte proliferation IMP 22696062
GO:0016337 single organismal cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with CDH3: view

No data available for SIGNOR curated interactions for CDH3 Gene

Drugs & Compounds for CDH3 Gene

(5) Drugs for CDH3 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for CDH3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CDH3: view

Transcripts for CDH3 Gene

Unigene Clusters for CDH3 Gene

Cadherin 3, type 1, P-cadherin (placental):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2: -
SP3: -
SP4: -
SP5:

Relevant External Links for CDH3 Gene

GeneLoc Exon Structure for
CDH3
ECgene alternative splicing isoforms for
CDH3

Expression for CDH3 Gene

mRNA expression in normal human tissues for CDH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH3 Gene

This gene is overexpressed in Ovary (x7.9), Esophagus - Mucosa (x6.5), and Minor Salivary Gland (x4.4).

Protein differential expression in normal tissues from HIPED for CDH3 Gene

This gene is overexpressed in Esophagus (22.8), Ovary (18.2), Islet of Langerhans (14.1), and Uterus (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDH3 Gene



SOURCE GeneReport for Unigene cluster for CDH3 Gene Hs.191842

mRNA Expression by UniProt/SwissProt for CDH3 Gene

P22223-CADH3_HUMAN
Tissue specificity: Expressed in some normal epithelial tissues and in some carcinoma cell lines.
genes like me logo Genes that share expression patterns with CDH3: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CDH3 Gene

Orthologs for CDH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDH3 35
  • 87.25 (n)
  • 87.7 (a)
CDH3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH3 35
  • 86.19 (n)
  • 87.56 (a)
CDH3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh3 35
  • 82.5 (n)
  • 83.27 (a)
Cdh3 16
Cdh3 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDH3 35
  • 99.44 (n)
  • 99.52 (a)
CDH3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh3 35
  • 82.82 (n)
  • 84.13 (a)
oppossum
(Monodelphis domestica)
Mammalia CDH3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH3 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH3 35
  • 69.55 (n)
  • 66.16 (a)
CDH3 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH3 36
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34061 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10910 35
zebrafish
(Danio rerio)
Actinopterygii cdh1 36
  • 46 (a)
ManyToMany
si:ch211-206i14.2 36
  • 43 (a)
ManyToMany
si:dkey-173l11.3 36
  • 36 (a)
ManyToMany
si:dkey-173l11.5 36
  • 36 (a)
ManyToMany
si:dkey-30c15.12 36
  • 41 (a)
ManyToMany
Species with no ortholog for CDH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH3 Gene

ENSEMBL:
Gene Tree for CDH3 (if available)
TreeFam:
Gene Tree for CDH3 (if available)

Paralogs for CDH3 Gene

Paralogs for CDH3 Gene

genes like me logo Genes that share paralogs with CDH3: view

Variants for CDH3 Gene

Sequence variations from dbSNP and Humsavar for CDH3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_015422 Hypotrichosis congenital with juvenile macular dystrophy (HJMD)
rs17854171 - 68,679,816(+) TGCAG(A/G)TGACA reference, missense
rs34494880 - 68,685,210(+) CTACC(A/G)CATCC reference, missense
rs1126933 - 68,687,630(+) CGCCA(C/G)GTGCT reference, missense
VAR_033010 Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS)

Structural Variations from Database of Genomic Variants (DGV) for CDH3 Gene

Variant ID Type Subtype PubMed ID
nsv457515 CNV Gain 19166990
nsv833267 CNV Gain 17160897
esv2668844 CNV Deletion 23128226
nsv827712 CNV Gain 20364138
esv1005955 CNV Deletion 20482838
esv2714657 CNV Deletion 23290073
esv1728945 CNV Deletion 17803354

Variation tolerance for CDH3 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.33; 85.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH3 Gene

HapMap Linkage Disequilibrium report
CDH3
Human Gene Mutation Database (HGMD)
CDH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH3 Gene

Disorders for CDH3 Gene

MalaCards: The human disease database

(16) MalaCards diseases for CDH3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ectodermal dysplasia, ectrodactyly, and macular dystrophy
  • eem syndrome
hypotrichosis, congenital, with juvenile macular dystrophy
  • hjmd
juvenile macular degeneration and hypotrichosis
  • hypotrichosis, congenital, with juvenile macular dystrophy
hypotrichosis
breast mucoepidermoid carcinoma
  • mucoepidermoid carcinoma of breast
- elite association - COSMIC cancer census association via MalaCards
Search CDH3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CADH3_HUMAN
  • Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS) [MIM:225280]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly. {ECO:0000269 PubMed:15805154}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hypotrichosis congenital with juvenile macular dystrophy (HJMD) [MIM:601553]: A disorder characterized by congenital hypotrichosis, early hair loss, and severe degenerative changes of the retinal macula that culminate in blindness during the second to third decade of life. {ECO:0000269 PubMed:11544476, ECO:0000269 PubMed:12445216}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CDH3

Genetic Association Database (GAD)
CDH3
Human Genome Epidemiology (HuGE) Navigator
CDH3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH3
genes like me logo Genes that share disorders with CDH3: view

No data available for Genatlas for CDH3 Gene

Publications for CDH3 Gene

  1. A missense mutation in CDH3, encoding P-cadherin, causes hypotrichosis with juvenile macular dystrophy. (PMID: 12445216) Indelman M. … Sprecher E. (J. Invest. Dermatol. 2002) 3 4 23 67
  2. Extracellular cleavage and shedding of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells. (PMID: 19901964) Ribeiro A.S. … Paredes J. (Oncogene 2010) 3 23
  3. Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer. (PMID: 20118984) Cheung L.W. … Wong A.S. (Oncogene 2010) 3 23
  4. The prognostic value of cadherin switch in bladder cancer. (PMID: 20204300) JAoger T. … Szarvas T. (Oncol. Rep. 2010) 3 23
  5. Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater. (PMID: 19043399) Baumhoer D. … Terracciano L.M. (Mod. Pathol. 2009) 3 23

Products for CDH3 Gene

Sources for CDH3 Gene

Back to Top

Content