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Aliases for CDH3 Gene

Aliases for CDH3 Gene

  • Cadherin 3, Type 1, P-Cadherin (Placental) 2 3
  • CDHP 3 4 6
  • HJMD 3 6
  • PCAD 3 6
  • Calcium-Dependent Adhesion Protein, Placental 3
  • Cadherin 3, P-Cadherin (Placental) 2
  • Placental Cadherin 4
  • Cadherin-3 3
  • P-Cadherin 4

External Ids for CDH3 Gene

Summaries for CDH3 Gene

Entrez Gene Summary for CDH3 Gene

  • This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH3 Gene

CDH3 (Cadherin 3, Type 1, P-Cadherin (Placental)) is a Protein Coding gene. Diseases associated with CDH3 include hypotrichosis, congenital, with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH13.

UniProtKB/Swiss-Prot for CDH3 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Wiki entry for CDH3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH3 Gene

Genomics for CDH3 Gene

Genomic Location for CDH3 Gene

Start:
68,636,189 bp from pter
End:
68,722,616 bp from pter
Size:
86,428 bases
Orientation:
Plus strand

Genomic View for CDH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH3 Gene

Regulatory Elements for CDH3 Gene

Proteins for CDH3 Gene

  • Protein details for CDH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22223-CADH3_HUMAN
    Recommended name:
    Cadherin-3
    Protein Accession:
    P22223
    Secondary Accessions:
    • B2R6F4
    • Q05DI6

    Protein attributes for CDH3 Gene

    Size:
    829 amino acids
    Molecular mass:
    91418 Da
    Quaternary structure:
    • Interacts with CDCP1 and CTNNB1.

    Alternative splice isoforms for CDH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH3 Gene

Proteomics data for CDH3 Gene at MOPED

Post-translational modifications for CDH3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn200 and Asn566

Other Protein References for CDH3 Gene

No data available for DME Specific Peptides for CDH3 Gene

Domains for CDH3 Gene

Gene Families for CDH3 Gene

HGNC:
  • MCDH :Cadherins / Major cadherins

UniProtKB/Swiss-Prot:

CADH3_HUMAN
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.:
    • P22223
  • Contains 5 cadherin domains.:
    • P22223
genes like me logo Genes that share domains with CDH3: view

Function for CDH3 Gene

Molecular function for CDH3 Gene

GENATLAS Biochemistry: cadherin 3,P-cadherin,placental,transmembrane glycoprotein component of adherens junction,expressed in placenta,forming a complex with the catenin that is loss in poorly differentiated esophageal squamous carcinoma
UniProtKB/Swiss-Prot Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Ontology (GO) - Molecular Function for CDH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDH3: view

Phenotypes for CDH3 Gene

MGI mutant phenotypes for CDH3:
inferred from 1 alleles
GenomeRNAi human phenotypes for CDH3:
genes like me logo Genes that share phenotypes with CDH3: view

Animal Models for CDH3 Gene

MGI Knock Outs for CDH3:

miRNA for CDH3 Gene

miRTarBase miRNAs that target CDH3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CDH3 Gene

Localization for CDH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH3 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH3 Gene COMPARTMENTS Subcellular localization image for CDH3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005913 cell-cell adherens junction IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH3: view

Pathways for CDH3 Gene

genes like me logo Genes that share pathways with CDH3: view

Pathways by source for CDH3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CDH3 Gene
1 Sino Biological pathway for CDH3 Gene
1 Cell Signaling Technology pathway for CDH3 Gene
1 KEGG pathway for CDH3 Gene

Gene Ontology (GO) - Biological Process for CDH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IMP 23143461
GO:0007155 cell adhesion TAS 2793940
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007601 visual perception IEA --
GO:0010628 positive regulation of gene expression IMP 23334344
genes like me logo Genes that share ontologies with CDH3: view

Compounds for CDH3 Gene

(1) HMDB Compounds for CDH3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(6) Novoseek inferred chemical compound relationships for CDH3 Gene

Compound -log(P) Hits PubMed IDs
estrogen 40.9 22
paraffin 37.3 8
progesterone 36.7 7
nitric oxide 4.76 2
calcium 0 16
genes like me logo Genes that share compounds with CDH3: view

Transcripts for CDH3 Gene

Unigene Clusters for CDH3 Gene

Cadherin 3, type 1, P-cadherin (placental):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2: -
SP3: -
SP4: -
SP5:

Relevant External Links for CDH3 Gene

GeneLoc Exon Structure for
CDH3
ECgene alternative splicing isoforms for
CDH3

Expression for CDH3 Gene

mRNA expression in normal human tissues for CDH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH3 Gene

This gene is overexpressed in Ovary (7.9), Esophagus - Mucosa (6.5), and Minor Salivary Gland (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDH3 Gene

SOURCE GeneReport for Unigene cluster for CDH3 Gene Hs.191842

mRNA Expression by UniProt/SwissProt for CDH3 Gene

P22223-CADH3_HUMAN
Tissue specificity: Expressed in some normal epithelial tissues and in some carcinoma cell lines.
genes like me logo Genes that share expressions with CDH3: view

Orthologs for CDH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH3 36
  • 99.44 (n)
  • 99.52 (a)
CDH3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDH3 36
  • 87.25 (n)
  • 87.7 (a)
CDH3 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH3 36
  • 86.19 (n)
  • 87.56 (a)
CDH3 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh3 36
  • 82.5 (n)
  • 83.27 (a)
Cdh3 16
Cdh3 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDH3 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH3 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh3 36
  • 82.82 (n)
  • 84.13 (a)
chicken
(Gallus gallus)
Aves CDH3 36
  • 69.55 (n)
  • 66.16 (a)
CDH3 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH3 37
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34061 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10910 36
zebrafish
(Danio rerio)
Actinopterygii cdh1 37
  • 46 (a)
ManyToMany
si:ch211-206i14.2 37
  • 43 (a)
ManyToMany
si:dkey-173l11.3 37
  • 36 (a)
ManyToMany
si:dkey-173l11.5 37
  • 36 (a)
ManyToMany
si:dkey-30c15.12 37
  • 41 (a)
ManyToMany
Species with no ortholog for CDH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH3 Gene

ENSEMBL:
Gene Tree for CDH3 (if available)
TreeFam:
Gene Tree for CDH3 (if available)

Paralogs for CDH3 Gene

Paralogs for CDH3 Gene

genes like me logo Genes that share paralogs with CDH3: view

Variants for CDH3 Gene

Sequence variations from dbSNP and Humsavar for CDH3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1075649 -- 68,679,354(-) CATGC(A/T)CTCAA intron-variant
rs1111720 -- 68,664,983(-) TAGAG(A/G)CAAGC intron-variant
rs1111721 -- 68,664,558(-) AGTGA(C/T)TCCCA intron-variant
rs1111722 -- 68,664,250(-) AATCA(G/T)TATGT intron-variant
rs1124770 -- 68,672,510(-) GAAGA(C/T)GAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH3 Gene

Variant ID Type Subtype PubMed ID
nsv457515 CNV Gain 19166990
nsv833267 CNV Gain 17160897
esv2668844 CNV Deletion 23128226
nsv827712 CNV Gain 20364138
esv1005955 CNV Deletion 20482838
esv2714657 CNV Deletion 23290073
esv1728945 CNV Deletion 17803354

Relevant External Links for CDH3 Gene

HapMap Linkage Disequilibrium report
CDH3
Human Gene Mutation Database (HGMD)
CDH3
Locus Specific Mutation Databases (LSDB)
CDH3

Disorders for CDH3 Gene

(2) OMIM Diseases for CDH3 Gene (114021)

UniProtKB/Swiss-Prot

CADH3_HUMAN
  • Hypotrichosis congenital with juvenile macular dystrophy (HJMD) [MIM:601553]: A disorder characterized by congenital hypotrichosis, early hair loss, and severe degenerative changes of the retinal macula that culminate in blindness during the second to third decade of life. {ECO:0000269 PubMed:11544476, ECO:0000269 PubMed:12445216}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS) [MIM:225280]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly. {ECO:0000269 PubMed:15805154}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for CDH3 Gene

(56) Novoseek inferred disease relationships for CDH3 Gene

Disease -log(P) Hits PubMed IDs
breast carcinoma 68.9 32
carcinoma lobular 57.6 5
darier disease 56.4 2
carcinoma 55.5 28
breast cancer 55.2 50

Relevant External Links for CDH3

Genetic Association Database (GAD)
CDH3
Human Genome Epidemiology (HuGE) Navigator
CDH3
genes like me logo Genes that share disorders with CDH3: view

Publications for CDH3 Gene

  1. P-cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer. (PMID: 9815605) Jarrard D.F. … Isaacs W.B. (Clin. Cancer Res. 1997) 3 4 23
  2. Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin. (PMID: 11544476) Sprecher E. … Szargel R. (Nat. Genet. 2001) 3 4 23
  3. A missense mutation in CDH3, encoding P-cadherin, causes hypotrichosis with juvenile macular dystrophy. (PMID: 12445216) Indelman M. … Sprecher E. (J. Invest. Dermatol. 2002) 3 4 23
  4. Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. (PMID: 11889072) Hardy R.G. … Jankowski J.A. (Gut 2002) 3 23
  5. Soluble fragment of P-cadherin adhesion protein found in human milk. (PMID: 11891861) Soler A.P. … Knudsen K.A. (J. Cell. Biochem. 2002) 3 23

Products for CDH3 Gene

  • Addgene plasmids for CDH3

Sources for CDH3 Gene

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