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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDH3 Gene

protein-coding GIFtS: 68
GCID: GC16P068679

cadherin 3, type 1, P-cadherin (placental)

(Previous names: cadherin 3, P-cadherin (placental) )

Explore 76 diseases affiliated with
CDH3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cadherin 3, Type 1, P-Cadherin (Placental)¹ ²		Cadherin-3¹
CDHP¹ ² ³ ⁵		Calcium-Dependent Adhesion Protein, Placental²
PCAD¹ ² ⁵		P-Cadherin¹
HJMD² ⁵		Placental Cadherin³
Cadherin 3, P-Cadherin (Placental)¹

External Ids:	HGNC: 1762¹	Entrez Gene: 1001²	Ensembl: ENSG00000062038⁷	OMIM: 114021⁵	UniProtKB: P22223³

Export aliases for CDH3 gene to outside databases

Previous GC identifers: GC16P059362 GC16P069056 GC16P068414 GC16P068454 GC16P067236 GC16P054551

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDH3:

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell

adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved

cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is

involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this

protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential

hypotrichosis with juvenile macular dystrophy. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CADH3_HUMAN, P22223

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a

homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Wiki entry for CDH3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDH3 gene promoter:
COUP-TF1 Sp1 AP-1 ATF-2 COUP HNF-4alpha2 HNF-4alpha1 AREB6 COUP-TF c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDH3 promoter sequence

Search SABiosciences Chromatin IP Primers for CDH3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDH3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1

CDH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH3 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P068679: view genomic region (about GC identifiers)

Start:	68,670,092 bp from pter	End:	68,756,519 bp from pter
Size:	86,428 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CADH3_HUMAN, P22223 (See protein sequence)

Recommended Name: Cadherin-3 precursor

Size: 829 amino acids; 91418 Da

Subunit: Interacts with CDCP1

Subcellular location: Cell membrane; Single-pass type I membrane protein

Secondary accessions: B2R6F4 Q05DI6

Alternative splicing: 2 isoforms: P22223-1 P22223-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDH3: NX_P22223

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P22223

CDH3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001784.2

ENSEMBL proteins:

ENSP00000264012 ENSP00000398485 ENSP00000464021 ENSP00000462111 ENSP00000464058

ENSP00000463267 ENSP00000463364 ENSP00000463415 ENSP00000462948

Reactome Protein details: P22223
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDH3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005913	cell-cell adherens junction	IEA	--
GO:0016021	integral to membrane	IEA	--

CDH3 for ontologies About GeneDecksing

CDH3 Antibody Products:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDH3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDH3 for domains About GeneDecksing

4 InterPro domains/families:

IPR000233 Cadherin_cytoplasmic-dom

IPR015919 Cadherin-like

IPR020894 Cadherin_CS

IPR002126 Cadherin

Graphical View of Domain Structure for InterPro Entry P22223

ProtoNet protein and cluster: P22223

2 Blocks protein families:

IPB000233 Cadherin cytoplasmic region

IPB002126 Cadherin

UniProtKB/Swiss-Prot: CADH3_HUMAN, P22223

Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections,

imparting a strong curvature to the full-length ectodomain (By similarity)

Similarity: Contains 5 cadherin domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CADH3_HUMAN, P22223

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a

homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Genatlas biochemistry entry for CDH3:

cadherin 3,P-cadherin,placental,transmembrane glycoprotein component of adherens junction,expressed in placenta,forming

a complex with the catenin that is loss in poorly differentiated esophageal squamous carcinoma

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		hsa-miR-3163 hsa-miR-330-5p hsa-miR-452* hsa-miR-219-5p hsa-miR-520a-5p hsa-miR-4314 hsa-miR-525-5p hsa-miR-326

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Gene Editing
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DNA2.0 Custom Protein Engineering Service for CDH3

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--

CDH3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CDH3:

Stronger migration

Animal Models:
Mouse knock-out Cdh3^tm1Hyn for CDH3
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cdh3):

endocrine/exocrine gland

integument

CDH3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell-cell junction organization

	Cell-cell junction organization	1.00			Adherens junctions interactions	0.51
	Cell junction organization	0.69			Cell-Cell communication	0.45

Rho Family GTPases

Rho Family GTPases

1.00

ILK Signaling

0.45

Cytoskeleton remodeling Slit-Robo signaling

Cell adhesion Cadherin-mediated cell adhesion

0.28

Cell adhesion_Cadherin-mediated cell adhesion

0.28

Adhesion

Adhesion

1.00

WNT Signaling

WNT Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CDH3

Cell adhesion Cadherin-mediated cell adhesion

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDH3 (see all 7)

	S-1P Stimulated Signaling
	ILK Signaling
	GSK3 Signaling
	G12-G13 in Cellular Signaling
	Presenilin-Mediated Signaling

1 Cell Signaling Technology (CST) Pathway for CDH3

Adhesion

1 GeneGo (Thomson Reuters) Pathway for CDH3

Cell adhesion Cadherin-mediated cell adhesion

4 Reactome Pathways for CDH3

	Adherens junctions interactions
	Cell junction organization
	Cell-Cell communication
	Cell-cell junction organization

1 Kegg Pathway (Kegg details for CDH3):

Cell adhesion molecules (CAMs)

CDH3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDH3

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/10 Interacting proteins for CDH3 (P22223³ ENSP00000264012⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTNND1	O60716³, ENSP00000382004⁴	I2D: score=3 STRING: ENSP00000382004
CTNNA1	P35221³, ENSP00000304669⁴	I2D: score=2 STRING: ENSP00000304669
CDH1	P12830³, ENSP00000261769⁴	I2D: score=1 STRING: ENSP00000261769
JUP	P14923³, ENSP00000311113⁴	I2D: score=1 STRING: ENSP00000311113
CTNNB1	P35222³, ENSP00000344456⁴	I2D: score=2 STRING: ENSP00000344456

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	2793940
GO:0007156	homophilic cell adhesion	IEA	--
GO:0007601	visual perception	IEA	--
GO:0016337	cell-cell adhesion	--	--
GO:0034329	cell junction assembly	TAS	--

CDH3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDH3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDH3

1 HMDB Compound for CDH3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

6 Novoseek chemical compound relationships for CDH3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estrogen	40.9	25	15548699 (3), 12608656 (3), 16115928 (2), 7534041 (1) (see all 17)
paraffin	37.3	8	12657131 (1), 18184410 (1), 16803529 (1), 18990147 (1) (see all 8)
progesterone	36.7	7	7534041 (1), 15933754 (1), 18811693 (1), 17146782 (1) (see all 7)
nitric oxide	4.76	2	14669304 (1), 16475686 (1)
calcium	0	23	9840799 (4), 9359492 (3), 10381572 (1), 9297684 (1) (see all 11)
tyrosine	0	2	9359492 (2)

Search CenterWatch for drugs/clinical trials and news about CDH3 / CADH3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDH3 gene:

NM_001793.4

Unigene Cluster for CDH3:

Cadherin 3, type 1, P-cadherin (placental)

Hs.191842 [show with all ESTs]

Unigene Representative Sequence: NM_001793

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000565453 ENST00000264012(uc002ewf.2 uc010vli.1) ENST00000429102

ENST00000542274 ENST00000566808 ENST00000569036 ENST00000567674 ENST00000568292

ENST00000569080 ENST00000569117 ENST00000581171

miRNA Products:		OriGene 3'-UTR Clone: CDH3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDH3
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		hsa-miR-3163 hsa-miR-330-5p hsa-miR-452* hsa-miR-219-5p hsa-miR-520a-5p hsa-miR-4314 hsa-miR-525-5p hsa-miR-326

		SwitchGear 3'UTR luciferase reporter plasmid: CDH3 3' UTR sequence

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Additional cDNA sequence:

AK225396.1 AK296968.1 AK312554.1 BC014462.1 BC041846.1 X63629.1

12 DOTS entries:

DT.113659 DT.100779495 DT.100779494 DT.91947365 DT.120665526 DT.120665528 DT.120665631 DT.75102866

DT.92033387 DT.95080929 DT.97780589 DT.95258646

24/160 AceView cDNA sequences (see all 160):

CA489338 BP351582 BG538137 BQ936686 BU168948 CA454360 AL040609 CA489357

C00249 CA455046 BM766222 BF915077 BM045728 CA489124 BE378969 CB997053

BG319601 BQ676796 CB996355 BM923882 CB992509 CF593464 AI827275 BQ928283

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CDH3 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14	^	15	^	16
SP1:																															-
SP2:					-
SP3:													-
SP4:							-
SP5:

ECgene alternative splicing isoforms for CDH3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDH3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACGGTGGCG

About this image

CDH3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

N2/LSB/S/F8-induced cells (Generation of midbra...)

See CDH3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDH3

SOURCE GeneReport for Unigene cluster: Hs.191842

UniProtKB/Swiss-Prot: CADH3_HUMAN, P22223

Tissue specificity: Expressed in some normal epithelial tissues and in some carcinoma cell lines

SABiosciences Expression via Pathway-Focused PCR Arrays including CDH3:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Adherens Junctions in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CDH3 gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CDH3¹	cadherin 3, type 1, P-cadherin (placental)	68.99(n) 65.91(a)		414845 XM_003641956.1 XP_003642004.1
African clawed frog (Xenopus laevis)	Amphibia	Xl.34061²	X.laevis mRNA for blastomere cadherin	73.03(n)		X78546.1
zebrafish (Danio rerio)	Actinopterygii	cdh1⁶ si:ch211-206i14.2⁶ (see all 5)	si:ch211-206i14.2 (see all 5)	45(a) 42(a) (see all 5)	many ↔ many many ↔ many (see all 5)	7(56206925-56228078) 7(56377825-56427099)

ENSEMBL Gene Tree for CDH3 (if available)
TreeFam Gene Tree for CDH3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDH3 gene

CDH4² CDH18² DSG4² CDH10² CDH11² CDH1² CDH6² DSC2²

CDH8² CDH20² CDH22² DSC1² CDH19² DSG1² CDH7² DSG2²

CDH9² CDH12² CDH26² DSC3² CDH2² CDH24² CDH15² CDH5²

DSG3²

18/27 SIMAP similar genes for CDH3 using alignment to 8 protein entries: CADH3_HUMAN (see all proteins) (see all similar genes):

CDH1 CDH2 CDH4 DSC2 CDH15 DKFZp434K1130

CDH13 DKFZp686P18250 CDH24 CDH7 CDH26 CDH9

DSC1 PCDH1 CDH11 CDH10 CDH19 CDH20

CDH3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121434542^1,2	C	pathogenic	68719191(+)	`CGACCG/ATGAGG`	2	/H /R	mis¹		1		NA	4552
rs34394404^1,2	C,F,	untested	68718588(+)	`TAGTGG/ATCCAC`	2	/I /V	mis¹		6		NA EU	6057
rs193921054^1,2	C	unknown	68710362(+)	`ATGGCA/GAGACA`	2	K E	mis¹		0	--	--	--	--
rs142696102^1,2		--	68676172(+)	`CTCAGC/TCTTCT`	1	--	us2k¹		0	--	--	--	--
rs183740082^1,2		--	68676448(+)	`GAAGGC/GAGCGG`	1	--	us2k¹		0	--	--	--	--
rs139607644^1,2		--	68676456(+)	`CGGTGC/TGGTCC`	1	--	us2k¹		0	--	--	--	--
rs149301678^1,2		--	68676634(+)	`TCCGCC/TTAATG`	1	--	us2k¹		0	--	--	--	--
rs188853192^1,2		--	68676682(+)	`GAGGCG/TAGCGT`	1	--	us2k¹		0	--	--	--	--
rs192717376^1,2		--	68676725(+)	`CTCCAC/TTGCGC`	1	--	us2k¹		0	--	--	--	--
rs62055321^1,2		--	68676783(+)	`CCTGCA/GGGAGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDH3 (68670092 - 68756519 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDH3: --
Human Gene Mutation Database (HGMD): CDH3

Locus Specific Mutation Databases (LSDB): CDH3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDH3

DNA2.0 Custom Variant and Variant Library Synthesis for CDH3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDH3 for disorders           About GeneDecksing

OMIM gene information: 114021
OMIM disorders: 601553  225280
UniProtKB/Swiss-Prot: CADH3_HUMAN, P22223

Defects in CDH3 are the cause of hypotrichosis with juvenile macular dystrophy (HJMD) [MIM:601553]. HJMD is a

rare autosomal recessive disorder characterized by early hair loss heralding severe degenerative changes of the

retinal macula and culminating in blindness during the second to third decade of life

Defects in CDH3 are the cause of ectodermal dysplasia with ectrodactyly and macular dystrophy (EEM)

[MIM:225280]; also known as EEM syndrome, Albrectsen-Svendsen syndrome or Ohdo-Hirayama-Terawaki syndrome. Ectodermal

dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures.

EEM is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and

scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly

20/76 diseases for CDH3 (see all 76): About MalaCards

macular dystrophy cervical adenocarcinoma hypotrichosis north american indian childhood cirrhosis

hailey-hailey disease prostate cancer cervicitis adenocarcinoma

malignant mixed mullerian tumor prostatitis ectodermal dysplasia malignant pleural mesothelioma

eem syndrome tooth agenesis pemphigus ectrodactyly

hereditary diffuse gastric cancer diffuse gastric cancer pituitary adenoma barrett's esophagus

2 diseases from the University of Copenhagen DISEASES database for CDH3:

Stomatitis Plague

10/56 Novoseek disease relationships for CDH3 gene (see all 56) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast carcinoma	68.9	32	10506713 (4), 14645693 (3), 12608656 (3), 16115928 (3) (see all 23)
carcinoma lobular	57.6	5	7534041 (1), 14645693 (1), 11921707 (1), 10506713 (1) (see all 5)
darier disease	56.4	3	11401672 (1), 15206690 (1)
carcinoma	55.5	33	14645693 (5), 7743525 (3), 9842964 (2), 10492037 (2) (see all 20)
breast cancer	55.2	56	15930334 (7), 18811693 (5), 19901964 (5), 18001487 (4) (see all 25)
carcinoma ductal	55.1	9	7534041 (2), 11942571 (2), 11454996 (1), 12608656 (1) (see all 7)
carcinoma medullary	50.6	2	10492037 (2)
tumors	47.8	81	15051772 (3), 16115928 (3), 16361544 (3), 8902651 (2) (see all 49)
pemphigus vulgaris	46.9	1	10771476 (1)
hailey-hailey disease	46.3	1	11401672 (1)

Human Genome Epidemiology (HuGE) Navigator: CDH3 (4 documents)

Export disorders for CDH3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDH3 gene, integrated from 9 sources (see all 285):
(articles sorted by number of sources associating them with CDH3)

Utopia: connect your pdf to the dynamic
world of online information

A missense mutation in CDH3, encoding P-cadherin, causes hypotrichosis with juvenile macular dystrophy. (PubMed id 12445216)^{1, 2, 9} Indelman M.... Sprecher E. (2002)
Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin. (PubMed id 11544476)^{1, 2, 9} Sprecher E....Szargel R. (2001)
P-cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer. (PubMed id 9815605)^{1, 2, 9} Jarrard D.F.... Isaacs W.B. (1997)
Adhesion signaling by a novel mitotic substrate of src kinases. (PubMed id 16007225)^{1, 2} Bhatt A.S.... Moasser M.M. (2005)
Distinct CDH3 mutations cause ectodermal dysplasia, ectrodactyly, macular dystrophy (EEM syndrome). (PubMed id 15805154)^{1, 2} Kjaer K.W.... Rosenberg T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. (PubMed id 1427864)^{1, 3} Kaupmann K....Starzinski-Powitz A. (1992)
Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues. (PubMed id 2793940)^{1, 2} Shimoyama Y....Hirohashi S. (1989)
Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. (PubMed id 2702654)^{1, 2} Shimoyama Y.... Abe O. (1989)
P-cadherin expression and survival rate in oral squamous cell carcinoma: an immunohistochemical study. (PubMed id 15967043)^{1, 9} Lo Muzio L....Carinci F. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1001	HGNC: 1762	AceView: CDH3	Ensembl:ENSG00000062038	euGenes: HUgn1001
ECgene: CDH3	Kegg: 1001	H-InvDB: CDH3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDH3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDH3	Genetics and Cytogenetics in Oncology and Haematology
Mutations of the CDH3 gene	http://www.retina-international.org/files/sci-news/cdh3mut.htm
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CDH3

Intellectual Property for CDH3 gene
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Patent Information for CDH3 gene:
Search GeneIP for patents involving CDH3

GeneCards and IP:
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cadherin 3, type 1, P-cadherin (placental)

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