Aliases for CDH3 Gene
External Ids for CDH3 Gene
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDH3 Gene
CDH3 (Cadherin 3, Type 1, P-Cadherin (Placental)) is a Protein Coding gene. Diseases associated with CDH3 include hypotrichosis, congenital, with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH13.
UniProtKB/Swiss-Prot for CDH3 Gene
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types