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Aliases for CDH26 Gene

Aliases for CDH26 Gene

  • Cadherin 26 2 3 5
  • Cadherin-Like Protein VR20 3 4
  • Cadherin-Like 26 2 3
  • VR20 3

External Ids for CDH26 Gene

Previous GeneCards Identifiers for CDH26 Gene

  • GC20P058261
  • GC20P059171
  • GC20P059218
  • GC20P057966
  • GC20P058533
  • GC20P055323

Summaries for CDH26 Gene

Entrez Gene Summary for CDH26 Gene

  • Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization and migration. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This gene encodes a cadherin domain-containing protein whose specific function has not yet been determined. Alternative splicing occurs at this locus and two transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH26 Gene

CDH26 (Cadherin 26) is a Protein Coding gene. Among its related pathways are ERK Signaling and WNT Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DSG2.

UniProtKB/Swiss-Prot for CDH26 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH26 Gene

Genomics for CDH26 Gene

Regulatory Elements for CDH26 Gene

Enhancers for CDH26 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDH26 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDH26 Gene

Chromosome:
20
Start:
59,955,831 bp from pter
End:
60,034,338 bp from pter
Size:
78,508 bases
Orientation:
Plus strand

Genomic View for CDH26 Gene

Genes around CDH26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH26 Gene

Proteins for CDH26 Gene

  • Protein details for CDH26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXH8-CAD26_HUMAN
    Recommended name:
    Cadherin-like protein 26
    Protein Accession:
    Q8IXH8
    Secondary Accessions:
    • A2A2M5
    • B3KNX3
    • Q6P5Y6
    • Q8TCH3
    • Q9BQN4
    • Q9NRU1

    Protein attributes for CDH26 Gene

    Size:
    852 amino acids
    Molecular mass:
    95278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDH26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH26 Gene

Proteomics data for CDH26 Gene at MOPED

Post-translational modifications for CDH26 Gene

  • Glycosylation at Asn 81, Asn 85, Asn 171, Asn 177, and Asn 462
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH26 Gene

No data available for DME Specific Peptides for CDH26 Gene

Domains & Families for CDH26 Gene

Gene Families for CDH26 Gene

Protein Domains for CDH26 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CDH26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXH8

UniProtKB/Swiss-Prot:

CAD26_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 4 cadherin domains.
genes like me logo Genes that share domains with CDH26: view

Function for CDH26 Gene

Molecular function for CDH26 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
genes like me logo Genes that share phenotypes with CDH26: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDH26 Gene

Localization for CDH26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH26 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH26 Gene COMPARTMENTS Subcellular localization image for CDH26 gene
Compartment Confidence
plasma membrane 5
extracellular 2
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CDH26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH26: view

Pathways & Interactions for CDH26 Gene

genes like me logo Genes that share pathways with CDH26: view

Pathways by source for CDH26 Gene

1 Sino Biological pathway for CDH26 Gene

Interacting Proteins for CDH26 Gene

Gene Ontology (GO) - Biological Process for CDH26 Gene

None

No data available for SIGNOR curated interactions for CDH26 Gene

Drugs & Compounds for CDH26 Gene

(1) Drugs for CDH26 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH26: view

Transcripts for CDH26 Gene

Unigene Clusters for CDH26 Gene

Cadherin 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH26 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c · 22d ^ 23 ^ 24a · 24b
SP1:
SP2: - - - - - -
SP3: -
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - -
SP12:

Relevant External Links for CDH26 Gene

GeneLoc Exon Structure for
CDH26
ECgene alternative splicing isoforms for
CDH26

Expression for CDH26 Gene

mRNA expression in normal human tissues for CDH26 Gene

mRNA differential expression in normal tissues according to GTEx for CDH26 Gene

This gene is overexpressed in Prostate (x6.7).

Protein differential expression in normal tissues from HIPED for CDH26 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDH26 Gene



SOURCE GeneReport for Unigene cluster for CDH26 Gene Hs.729046

genes like me logo Genes that share expression patterns with CDH26: view

Protein tissue co-expression partners for CDH26 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CDH26 Gene

Orthologs for CDH26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH26 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDH26 35
  • 74.7 (n)
  • 67.35 (a)
CDH26 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH26 35
  • 74.76 (n)
  • 66.42 (a)
CDH26 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh26 35
  • 76.09 (n)
  • 67.66 (a)
Cdh26 16
Cdh26 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDH26 35
  • 99.04 (n)
  • 98.44 (a)
CDH26 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh26 35
  • 75.77 (n)
  • 66.58 (a)
oppossum
(Monodelphis domestica)
Mammalia CDH26 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH26 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH26 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh26 35
  • 53.46 (n)
  • 44.36 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-96b22.2 35
  • 48.15 (n)
  • 40.13 (a)
CDH26 36
  • 34 (a)
OneToOne
Species with no ortholog for CDH26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH26 Gene

ENSEMBL:
Gene Tree for CDH26 (if available)
TreeFam:
Gene Tree for CDH26 (if available)

Paralogs for CDH26 Gene

Paralogs for CDH26 Gene

(8) SIMAP similar genes for CDH26 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDH26: view

Variants for CDH26 Gene

Sequence variations from dbSNP and Humsavar for CDH26 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6015609 - 59,982,960(+) AAAAA(C/T)TGTGG reference, missense
rs11086690 - 59,987,516(+) AAGAT(C/G/T)GAGAT reference, missense
rs34866303 - 59,992,437(-) TGATG(A/G)CCACT reference, missense
VAR_055571 -
rs194998 - 59,996,009(+) TTCAT(G/T)TGGGG upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDH26 Gene

Variant ID Type Subtype PubMed ID
esv1009769 CNV Deletion 20482838
nsv817901 CNV Loss 17921354

Variation tolerance for CDH26 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDH26 Gene

Disorders for CDH26 Gene

Relevant External Links for CDH26

Genetic Association Database (GAD)
CDH26
Human Genome Epidemiology (HuGE) Navigator
CDH26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH26

No disorders were found for CDH26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDH26 Gene

Publications for CDH26 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Association and interaction analyses of eight genes under asthma linkage peaks. (PMID: 19824886) Ferreira M.A. … Duffy D.L. (Allergy 2009) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CDH26 Gene

Sources for CDH26 Gene

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