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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDH26 Gene

protein-coding GIFtS: 48
GCID: GC20P058533

cadherin 26

(Previous name: cadherin-like 26 )

Explore 1 disease affiliated with
CDH26 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cadherin 26¹ ²
VR20¹ ²
Cadherin-Like 26¹ ²
Cadherin-Like Protein VR20² ³
Cadherin-Like Protein 26²

External Ids:	HGNC: 15902¹	Entrez Gene: 60437²	Ensembl: ENSG00000124215⁷	UniProtKB: Q8IXH8³

Export aliases for CDH26 gene to outside databases

Previous GC identifers: GC20P058261 GC20P059171 GC20P059218 GC20P057966 GC20P055323

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDH26:

Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues and

modulate a wide variety of processes, including cell polarization and migration. Cadherin domains occur as repeats in

the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance

of orderly structures such as epithelium. This gene encodes a cadherin domain-containing protein whose specific

function has not yet been determined. Alternative splicing occurs at this locus and two transcript variants, encoding

distinct proteins, have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAD26_HUMAN, Q8IXH8

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a

homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDH26 gene promoter:
AhR Olf-1 POU6F1 (c2) NF-kappaB Arnt FOXL1 AREB6 E2F-1 E2F NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDH26 promoter sequence

Search SABiosciences Chromatin IP Primers for CDH26

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDH26

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33

CDH26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH26 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P058533: view genomic region (about GC identifiers)

Start:	58,533,471 bp from pter	End:	58,609,066 bp from pter
Size:	75,596 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAD26_HUMAN, Q8IXH8 (See protein sequence)

Recommended Name: Cadherin-like protein 26 precursor

Size: 852 amino acids; 95278 Da

Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)

Secondary accessions: A2A2M5 B3KNX3 Q6P5Y6 Q8TCH3 Q9BQN4 Q9NRU1

Alternative splicing: 4 isoforms: Q8IXH8-1 Q8IXH8-2 Q8IXH8-4 Q8IXH8-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDH26: NX_Q8IXH8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IXH8

CDH26 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_068582.2 NP_817089.1

ENSEMBL proteins:

ENSP00000339390 ENSP00000360030 ENSP00000244049 ENSP00000310845 ENSP00000407939

ENSP00000244047

Human Recombinant Protein Products for CDH26:

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	Uscn Proteins for CDH26

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

CDH26 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CDH26

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDH26 for domains About GeneDecksing

3 InterPro domains/families:

IPR015919 Cadherin-like

IPR020894 Cadherin_CS

IPR002126 Cadherin

Graphical View of Domain Structure for InterPro Entry Q8IXH8

ProtoNet protein and cluster: Q8IXH8

1 Blocks protein family: IPB002126 Cadherin

UniProtKB/Swiss-Prot: CAD26_HUMAN, Q8IXH8

Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections,

imparting a strong curvature to the full-length ectodomain (By similarity)

Similarity: Contains 4 cadherin domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CAD26_HUMAN, Q8IXH8

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a

homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--

CDH26 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CDH26:

Increased G2M DNA content

Upregulation of Wnt/beta-caten

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDH26

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDH26
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH26

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

WNT Signaling

WNT Signaling

1.00

S-1P Stimulated Signaling

S-1P Stimulated Signaling

1.00

G12-G13 in Cellular Signaling

G12-G13 in Cellular Signaling

1.00

Nanog in Mammalian ESC Pluripotency

GSK3 Signaling

0.61

Rho Family GTPases

ILK Signaling

0.45

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDH26

	S-1P Stimulated Signaling
	ILK Signaling
	GSK3 Signaling
	G12-G13 in Cellular Signaling
	WNT Signaling

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CDH26

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007156	homophilic cell adhesion	IEA	--

CDH26 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDH26

1 HMDB Compound for CDH26 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about CDH26 / CAD26

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDH26 gene (2 alternative transcripts):

NM_021810.4 NM_177980.2

Unigene Cluster for CDH26:

Cadherin 26

Hs.729046 [show with all ESTs]

Unigene Representative Sequence: NM_177980

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000348616(uc002ybe.3 uc010zzy.2) ENST00000477058 ENST00000370991

ENST00000497614 ENST00000244049(uc002ybi.3) ENST00000350849(uc002ybh.3)

ENST00000456106 ENST00000244047(uc002ybf.1)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDH26

Additional cDNA sequence:

AF169690.1 AK055202.1 AK074477.1 BC062570.1 BC136306.1 BC143931.1

7 DOTS entries:

DT.95260816 DT.75147039 DT.101978123 DT.40200038 DT.100834784 DT.120818523 DT.309021

24/34 AceView cDNA sequences (see all 34):

AF169690 AA282956 AW303344 AI090934 AA236545 NM_021810 AA454986 AI368936

F08337 CR624927 NM_177980 AK055202 BX454460 BI821876 AA282955 AK074477

BV198142 BU660607 BG289314 BX491682 BC062570 BX110707 AI202518 AA232735

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CDH26 (see all 12) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	^	16a	·	16b	·	16c	^
SP1:							-								-								-		-												-										-		-		-
SP2:																																					-										-		-		-
SP3:																																															-		-		-
SP4:
SP5:							-

ExUns:	17	^	18	^	19	^	20	^	21	^	22a	·	22b	·	22c	·	22d	^	23	^	24a	·	24b
SP1:
SP2:					-		-				-		-		-		-
SP3:					-
SP4:	-
SP5:

ECgene alternative splicing isoforms for CDH26

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDH26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTGGACA

About this image

CDH26 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDH26 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDH26

SOURCE GeneReport for Unigene cluster: Hs.729046

SABiosciences Custom PCR Arrays for CDH26

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CDH26 gene from 2/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CDH26⁶	--	48(a)	1 ↔ 1	4(148153956-148180360)
zebrafish (Danio rerio)	Actinopterygii	LOC571792¹	cadherin-like protein 26-like	47.86(n) 40(a)		571792 XM_695420.5 XP_700512.5

ENSEMBL Gene Tree for CDH26 (if available)
TreeFam Gene Tree for CDH26 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDH26 gene

CDH4² CDH18² DSG4² CDH3² CDH10² CDH11² CDH1² CDH6²

DSC2² CDH8² CDH20² CDH22² DSC1² CDH19² DSG1² CDH7²

DSG2² CDH9² CDH12² DSC3² CDH2² CDH24² CDH15² CDH5²

DSG3²

8 SIMAP similar genes for CDH26 using alignment to 4 protein entries: CAD26_HUMAN (see all proteins):

CDH13 CDH2 CDH1 DSC2 CDH3 CDH4

DKFZp686P18250 CDH22

CDH26 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs144523734^1,2	--	58531481(+)	`AAGTTA/TTTGGG`	1	--	us2k¹		0	--	--	--	--
rs199731390^1,2	--	58531620(+)	`CTCTT-/CCCCCC`	1	--	us2k¹		0	--	--	--	--
rs181699601^1,2	--	58531649(+)	`GTATGA/G/TTTCTT`	1	--	us2k¹		0	--	--	--	--
rs148435534^1,2	--	58531686(+)	`TCCCAC/GAAATC`	1	--	us2k¹		0	--	--	--	--
rs186768129^1,2	--	58531848(+)	`ATATAC/TACATA`	1	--	us2k¹		0	--	--	--	--
rs144025388^1,2	--	58531863(+)	`TGTGTA/GTATAT`	1	--	us2k¹		0	--	--	--	--
rs145965416^1,2	--	58531929(+)	`CATATA/GTGTGT`	1	--	us2k¹		0	--	--	--	--
rs201147008^1,2	--	58532000(+)	`TATAT-/ACACATA`	1	--	us2k¹		0	--	--	--	--
rs201789799^1,2	--	58532009(+)	`TATAT-/GCGTGTA`	1	--	us2k¹		0	--	--	--	--
rs191267460^1,2	--	58532010(+)	`ATATGC/TGTGTA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDH26 (58533471 - 58609066 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CDH26
4 CNVs: 90632 10585 79255 90633

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDH26

DNA2.0 Custom Variant and Variant Library Synthesis for CDH26

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDH26 for disorders About GeneDecksing

1 disease for CDH26: About MalaCards

asthma

Human Genome Epidemiology (HuGE) Navigator: CDH26 (2 documents)

Export disorders for CDH26 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDH26 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CDH26)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Association and interaction analyses of eight genes u nder asthma linkage peaks. (PubMed id 19824886)¹ Ferreira M.A....Duffy D.L. (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PubMed id 10835267)¹ Nollet F....van Roy F. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 60437	HGNC: 15902	AceView: CDH26	Ensembl:ENSG00000124215	euGenes: HUgn60437
ECgene: CDH26	H-InvDB: CDH26

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDH26	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CDH26 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CDH26 gene:
Search GeneIP for patents involving CDH26

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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