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Aliases for CDH26 Gene

Aliases for CDH26 Gene

  • Cadherin 26 2 3
  • Cadherin-Like Protein VR20 3 4
  • Cadherin-Like 26 2 3
  • Cadherin-Like Protein 26 3
  • VR20 3

External Ids for CDH26 Gene

Summaries for CDH26 Gene

Entrez Gene Summary for CDH26 Gene

  • Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization and migration. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This gene encodes a cadherin domain-containing protein whose specific function has not yet been determined. Alternative splicing occurs at this locus and two transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH26 Gene

CDH26 (Cadherin 26) is a Protein Coding gene. Among its related pathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH13.

UniProtKB/Swiss-Prot for CDH26 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH26 Gene

Genomics for CDH26 Gene

Genomic Location for CDH26 Gene

Start:
59,958,416 bp from pter
End:
60,034,011 bp from pter
Size:
75,596 bases
Orientation:
Plus strand

Genomic View for CDH26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDH26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH26 Gene

Regulatory Elements for CDH26 Gene

Proteins for CDH26 Gene

  • Protein details for CDH26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXH8-CAD26_HUMAN
    Recommended name:
    Cadherin-like protein 26
    Protein Accession:
    Q8IXH8
    Secondary Accessions:
    • A2A2M5
    • B3KNX3
    • Q6P5Y6
    • Q8TCH3
    • Q9BQN4
    • Q9NRU1

    Protein attributes for CDH26 Gene

    Size:
    852 amino acids
    Molecular mass:
    95278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDH26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH26 Gene

Proteomics data for CDH26 Gene at MOPED

Post-translational modifications for CDH26 Gene

  • Glycosylation at Asn81, Asn85, Asn171, Asn177, and Asn462

Other Protein References for CDH26 Gene

No data available for DME Specific Peptides for CDH26 Gene

Domains for CDH26 Gene

Gene Families for CDH26 Gene

HGNC:
  • MCDH :Cadherins / Major cadherins

Protein Domains for CDH26 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CAD26_HUMAN
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.:
    • Q8IXH8
  • Contains 4 cadherin domains.:
    • Q8IXH8
genes like me logo Genes that share domains with CDH26: view

Function for CDH26 Gene

Molecular function for CDH26 Gene

UniProtKB/Swiss-Prot Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Ontology (GO) - Molecular Function for CDH26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDH26: view

Phenotypes for CDH26 Gene

genes like me logo Genes that share phenotypes with CDH26: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDH26 Gene

Localization for CDH26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH26 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH26 Gene COMPARTMENTS Subcellular localization image for CDH26 gene
Compartment Confidence
plasma membrane 5
extracellular 2
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CDH26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH26: view

Pathways for CDH26 Gene

genes like me logo Genes that share pathways with CDH26: view

Pathways by source for CDH26 Gene

1 Sino Biological pathway for CDH26 Gene

Interacting Proteins for CDH26 Gene

Gene Ontology (GO) - Biological Process for CDH26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with CDH26: view

Compounds for CDH26 Gene

(1) HMDB Compounds for CDH26 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CDH26: view

Transcripts for CDH26 Gene

Unigene Clusters for CDH26 Gene

Cadherin 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH26 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c · 22d ^ 23 ^ 24a · 24b
SP1:
SP2: - - - - - -
SP3: -
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - -
SP12:

Relevant External Links for CDH26 Gene

GeneLoc Exon Structure for
CDH26
ECgene alternative splicing isoforms for
CDH26

Expression for CDH26 Gene

mRNA expression in normal human tissues for CDH26 Gene

mRNA differential expression in normal tissues according to GTEx for CDH26 Gene

This gene is overexpressed in Prostate (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDH26 Gene

SOURCE GeneReport for Unigene cluster for CDH26 Gene Hs.729046

genes like me logo Genes that share expressions with CDH26: view

Orthologs for CDH26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH26 36
  • 99.04 (n)
  • 98.44 (a)
CDH26 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDH26 36
  • 74.7 (n)
  • 67.35 (a)
CDH26 37
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH26 36
  • 74.76 (n)
  • 66.42 (a)
CDH26 37
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh26 36
  • 76.09 (n)
  • 67.66 (a)
Cdh26 16
Cdh26 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDH26 37
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH26 37
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh26 36
  • 75.77 (n)
  • 66.58 (a)
lizard
(Anolis carolinensis)
Reptilia CDH26 37
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh26 36
  • 53.46 (n)
  • 44.36 (a)
zebrafish
(Danio rerio)
Actinopterygii CDH26 37
  • 34 (a)
OneToOne
si:ch73-96b22.2 36
  • 48.15 (n)
  • 40.13 (a)
Species with no ortholog for CDH26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH26 Gene

ENSEMBL:
Gene Tree for CDH26 (if available)
TreeFam:
Gene Tree for CDH26 (if available)

Paralogs for CDH26 Gene

Paralogs for CDH26 Gene

Selected SIMAP similar genes for CDH26 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDH26: view

Variants for CDH26 Gene

Sequence variations from dbSNP and Humsavar for CDH26 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs168977 -- 59,961,411(+) TAGAT(A/G)TAAGA intron-variant
rs168978 -- 59,978,956(+) cttgt(A/G)tacgg intron-variant
rs168979 -- 59,979,690(-) gagat(C/T)gcacc intron-variant
rs168980 -- 59,989,318(-) ATCTC(C/T)TGACC intron-variant
rs168981 -- 59,993,317(-) atcta(C/T)gtaac intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDH26 Gene

Variant ID Type Subtype PubMed ID
esv1009769 CNV Deletion 20482838
nsv817901 CNV Loss 17921354

Relevant External Links for CDH26 Gene

HapMap Linkage Disequilibrium report
CDH26

Disorders for CDH26 Gene

Relevant External Links for CDH26

Genetic Association Database (GAD)
CDH26
Human Genome Epidemiology (HuGE) Navigator
CDH26
genes like me logo Genes that share disorders with CDH26: view

No data available for UniProtKB/Swiss-Prot for CDH26 Gene

Publications for CDH26 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Association and interaction analyses of eight genes under asthma linkage peaks. (PMID: 19824886) Ferreira M.A. … Duffy D.L. (Allergy 2009) 3 49
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PMID: 17903302) Levy D. … Mitchell G.F. (BMC Med. Genet. 2007) 49

Products for CDH26 Gene

Sources for CDH26 Gene

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