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CDH26 Gene

protein-coding   GIFtS: 47
GCID: GC20P058533

Cadherin 26

(Previous name: cadherin-like 26)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cadherin 261 2
Cadherin-Like 261 2
Cadherin-Like Protein VR202 3
VR202
Cadherin-Like Protein 262

External Ids:    HGNC: 159021   Entrez Gene: 604372   Ensembl: ENSG000001242157   UniProtKB: Q8IXH83   

Export aliases for CDH26 gene to outside databases

Previous GC identifers: GC20P058261 GC20P059171 GC20P059218 GC20P057966 GC20P055323


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDH26 Gene:
Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues
and modulate a wide variety of processes, including cell polarization and migration. Cadherin domains occur as
repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and
the maintenance of orderly structures such as epithelium. This gene encodes a cadherin domain-containing protein
whose specific function has not yet been determined. Alternative splicing occurs at this locus and two transcript
variants, encoding distinct proteins, have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDH26 Gene:
CDH26 (cadherin 26) is a protein-coding gene. Diseases associated with CDH26 include asthma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DSC1.

UniProtKB/Swiss-Prot: CAD26_HUMAN, Q8IXH8
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CDH26 gene promoter:
         AhR   Olf-1   POU6F1 (c2)   NF-kappaB   Arnt   FOXL1   AREB6   E2F-1   E2F   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDH26 promoter sequence
   Search Chromatin IP Primers for CDH26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDH26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

CDH26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH26 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P058533:  view genomic region     (about GC identifiers)

Start:
58,533,471 bp from pter      End:
58,609,066 bp from pter
Size:
75,596 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAD26_HUMAN, Q8IXH8 (See protein sequence)
Recommended Name: Cadherin-like protein 26 precursor  
Size: 852 amino acids; 95278 Da
Secondary accessions: A2A2M5 B3KNX3 Q6P5Y6 Q8TCH3 Q9BQN4 Q9NRU1
Alternative splicing: 4 isoforms:  Q8IXH8-1   Q8IXH8-2   Q8IXH8-4   Q8IXH8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDH26: NX_Q8IXH8

Explore proteomics data for CDH26 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn81, Asn85, Asn171, Asn177, Asn462

  • See CDH26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_068582.2  NP_817089.1  

    ENSEMBL proteins: 
     ENSP00000339390   ENSP00000360030   ENSP00000244049   ENSP00000310845   ENSP00000407939  
     ENSP00000244047  

    CDH26 Human Recombinant Protein Products:

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    CDH26 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MCDH: Cadherins / Major cadherins

    3 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q8IXH8

    ProtoNet protein and cluster: Q8IXH8

    1 Blocks protein domain: IPB002126 Cadherin

    UniProtKB/Swiss-Prot: CAD26_HUMAN, Q8IXH8
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the
    connections, imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 4 cadherin domains


    CDH26 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAD26_HUMAN, Q8IXH8
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
    a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    CDH26 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDH26:
     Increased G2M DNA content  Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Cdh26 (no phenotypes)

    CDH26 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDH26
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDH26
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDH26

    miRNA
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    Block miRNA regulation of human, mouse, rat CDH26 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CDH26:
    hsa-miR-515-5p hsa-miR-659 hsa-miR-4251 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidCDH26 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDH26

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    Sino Biological Human cDNA Clone for CDH26
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH26

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH26


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAD26_HUMAN, Q8IXH8: Cell membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    golgi apparatus1
    lysosome1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    CDH26 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDH26 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    2Non-Canonical Wnt Pathway
    Canonical Wnt Pathway0.53
    3ERK Signaling
    ILK Signaling0.49
    4WNT Signaling
    WNT Signaling
    5S-1P Stimulated Signaling
    S-1P Stimulated Signaling

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDH26
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    WNT Signaling

    1 Sino Biological Pathway for CDH26
        Canonical Wnt Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDH26
    Interactions:

        Search GeneGlobe Interaction Network for CDH26

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion IEA--

    CDH26 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDH26 (CAD26)

    1 HMDB Compound for CDH26    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDH26 gene (2 alternative transcripts): 
    NM_021810.4  NM_177980.2  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348616(uc002ybe.3 uc010zzy.2) ENST00000477058 ENST00000370991
    ENST00000497614 ENST00000244049(uc002ybi.3) ENST00000350849(uc002ybh.3)
    ENST00000456106 ENST00000244047(uc002ybf.1)
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate CDH26:
    hsa-miR-515-5p hsa-miR-659 hsa-miR-4251 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidCDH26 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CDH26
      QuantiFast Probe-based Assays in human, mouse, rat CDH26

    Selected AceView cDNA sequences (see all 34):

    NM_021810 F08337 AW303344 AI090934 AA454986 AF169690 AK055202 CR624927 
    AA282956 AA236545 NM_177980 AI368936 BI821876 BX454460 AA282955 BU660607 
    BX491682 AK074477 BC062570 BX110707 BV198142 BG289314 W25444 BG429310 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDH26 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^
    SP1:                    -                       -                       -     -                                   -                             -     -     -   
    SP2:                                                                                                              -                             -     -     -   
    SP3:                                                                                                                                            -     -     -   
    SP4:                                                                                                                                                            
    SP5:                    -                                                                                                                                       

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c · 22d ^ 23 ^ 24a · 24b
    SP1:                                                                        
    SP2:              -     -           -     -     -     -                     
    SP3:              -                                                         
    SP4:  -                                                                     
    SP5:                                                                        


    ECgene alternative splicing isoforms for CDH26

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDH26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTGGACA
    CDH26 Expression
    About this image

    CDH26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDH26 Protein Expression
        Custom PCR Arrays for CDH26
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDH26 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdh261 , 5 cadherin-like 261, 5 76.09(n)1
    67.66(a)1
      2 (99.94 cM)5
    3814091  NM_198656.11  NP_941058.11 
     1784305315 
    lizard
    (Anolis carolinensis)
    Reptilia CDH266
    cadherin 26
    43(a)
    1 ↔ 1
    4(148134236-148182155)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdh261 cadherin 26 53.46(n)
    44.36(a)
      595076  XM_004919723.1  XP_004919780.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-96b22.21 si:ch73-96b22.2 48.15(n)
    40.13(a)
      571792  XM_695420.6  XP_700512.6 


    ENSEMBL Gene Tree for CDH26 (if available)
    TreeFam Gene Tree for CDH26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDH26 gene
    DSC12  CDH42  DSG42  DSG12  CDH132  CDH32  DSG22  CDH12  
    DSC32  CDH22  DSC22  CDH152  DSG32  
    8 SIMAP similar genes for CDH26 using alignment to 4 protein entries:     CAD26_HUMAN (see all proteins):
    CDH13    CDH2    CDH1    DSC2    CDH3    CDH4
    DKFZp686P18250    CDH22

    CDH26 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDH26 (see all 1371)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445237341,2
    C--58531481(+) AAGTTA/TTTGGG 1 -- us2k10--------
    rs1997313901,2
    C--58531620(+) CTCTT-/CCCCCC 1 -- us2k10--------
    rs1816996011,2
    --58531649(+) GTATGA/G/TTTCTT 1 -- us2k10--------
    rs1484355341,2
    --58531686(+) TCCCAC/GAAATC 1 -- us2k10--------
    rs1867681291,2
    C--58531848(+) ATATAC/TACATA 1 -- us2k10--------
    rs1440253881,2
    --58531863(+) TGTGTA/GTATAT 1 -- us2k10--------
    rs1459654161,2
    --58531929(+) CATATA/GTGTGT 1 -- us2k10--------
    rs2011470081,2
    --58532000(+) TATAT-/ACACATA 1 -- us2k10--------
    rs2017897991,2
    --58532009(+) TATAT-/GCGTGTA 1 -- us2k10--------
    rs1912674601,2
    --58532010(+) ATATGC/TGTGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDH26 (58533471 - 58609066 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CDH26:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1009769CNV Deletion20482838
    nsv817901CNV Loss17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDH26
    DNA2.0 Custom Variant and Variant Library Synthesis for CDH26

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for CDH26:    
    About MalaCards
    asthma


    CDH26 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDH26
    Human Genome Epidemiology (HuGE) Navigator: CDH26 (2 documents)

    Export disorders for CDH26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDH26 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CDH26)
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    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Association and interaction analyses of eight genes under asthma linkage peaks. (PubMed id 19824886)1, 4 Ferreira M.A....Duffy D.L. (Allergy 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PubMed id 10835267)1 Nollet F....van Roy F. (J. Mol. Biol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 60437 HGNC: 15902 AceView: CDH26 Ensembl:ENSG00000124215 euGenes: HUgn60437
    ECgene: CDH26 H-InvDB: CDH26

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDH26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDH26 gene:
    Search GeneIP for patents involving CDH26

    GeneCards and IP:
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