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Aliases for CDH26 Gene

Aliases for CDH26 Gene

  • Cadherin 26 2 3 5
  • Cadherin-Like Protein VR20 3 4
  • Cadherin-Like 26 2 3
  • Cadherin-Like Protein 26 3
  • VR20 3

External Ids for CDH26 Gene

Previous GeneCards Identifiers for CDH26 Gene

  • GC20P058261
  • GC20P059171
  • GC20P059218
  • GC20P057966
  • GC20P058533
  • GC20P055323

Summaries for CDH26 Gene

Entrez Gene Summary for CDH26 Gene

  • This gene encodes a member of the cadherin protein family. Cadherins are a family of calcium-dependent adhesion molecules that mediate cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization, migration and differentiation. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This protein is expressed in gastrointestinal epithelial cells and may be upregulated during allergic inflammation. This protein interacts with alpha integrins and may also be involved in leukocyte migration and adhesion. [provided by RefSeq, Jan 2017]

GeneCards Summary for CDH26 Gene

CDH26 (Cadherin 26) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and ERK Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH2.

UniProtKB/Swiss-Prot for CDH26 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH26 Gene

Genomics for CDH26 Gene

Regulatory Elements for CDH26 Gene

Enhancers for CDH26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G059994 1 Ensembl ENCODE 11 +39.2 39172 2.0 GTF2F1 PKNOX1 CEBPG RAD21 CTBP1 ZFHX2 ELK1 POLR2A FOS RCOR1 C20orf197 CDH26
GH20G059976 0.4 dbSUPER 17.2 +21.1 21056 0.7 SIX4 PRDM6 CDH26 C20orf197
GH20G059993 0.5 ENCODE 11 +38.1 38090 0.2 ZFHX2 KDM1A EGR2 C20orf197 CDH26
GH20G059996 0.5 ENCODE 11 +40.5 40450 0.2 CBX8 RFX1 CUX1 C20orf197 CDH26
GH20G059977 0.4 FANTOM5 12.8 +21.6 21578 0.1 EGR2 CDH26 C20orf197 PHACTR3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDH26 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDH26 Gene

Chromosome:
20
Start:
59,955,831 bp from pter
End:
60,034,338 bp from pter
Size:
78,508 bases
Orientation:
Plus strand

Genomic View for CDH26 Gene

Genes around CDH26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH26 Gene

Proteins for CDH26 Gene

  • Protein details for CDH26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXH8-CAD26_HUMAN
    Recommended name:
    Cadherin-like protein 26
    Protein Accession:
    Q8IXH8
    Secondary Accessions:
    • A2A2M5
    • B3KNX3
    • Q6P5Y6
    • Q8TCH3
    • Q9BQN4
    • Q9NRU1

    Protein attributes for CDH26 Gene

    Size:
    852 amino acids
    Molecular mass:
    95278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDH26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH26 Gene

Post-translational modifications for CDH26 Gene

  • Glycosylation at Asn81, posLast=8585, posLast=171171, Asn177, and posLast=462462
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDH26 Gene

Domains & Families for CDH26 Gene

Gene Families for CDH26 Gene

Protein Domains for CDH26 Gene

Suggested Antigen Peptide Sequences for CDH26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXH8

UniProtKB/Swiss-Prot:

CAD26_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH26: view

Function for CDH26 Gene

Molecular function for CDH26 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Ontology (GO) - Molecular Function for CDH26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH26: view
genes like me logo Genes that share phenotypes with CDH26: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDH26 Gene

Localization for CDH26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH26 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH26 gene
Compartment Confidence
plasma membrane 5
extracellular 2
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDH26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH26: view

Pathways & Interactions for CDH26 Gene

genes like me logo Genes that share pathways with CDH26: view

Pathways by source for CDH26 Gene

1 Sino Biological pathway for CDH26 Gene

Interacting Proteins for CDH26 Gene

Gene Ontology (GO) - Biological Process for CDH26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with CDH26: view

No data available for SIGNOR curated interactions for CDH26 Gene

Drugs & Compounds for CDH26 Gene

(1) Drugs for CDH26 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH26: view

Transcripts for CDH26 Gene

Unigene Clusters for CDH26 Gene

Cadherin 26:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH26 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c · 22d ^ 23 ^ 24a · 24b
SP1:
SP2: - - - - - -
SP3: -
SP4: -
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11: - - - - - - - - -
SP12:

Relevant External Links for CDH26 Gene

GeneLoc Exon Structure for
CDH26
ECgene alternative splicing isoforms for
CDH26

Expression for CDH26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDH26 Gene

mRNA differential expression in normal tissues according to GTEx for CDH26 Gene

This gene is overexpressed in Prostate (x6.7).

Protein differential expression in normal tissues from HIPED for CDH26 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH26 Gene



Protein tissue co-expression partners for CDH26 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDH26 Gene:

CDH26

SOURCE GeneReport for Unigene cluster for CDH26 Gene:

Hs.729046

Evidence on tissue expression from TISSUES for CDH26 Gene

  • Lung(4.1)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with CDH26: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH26 Gene

Orthologs for CDH26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH26 34 35
  • 99.04 (n)
mouse
(Mus musculus)
Mammalia Cdh26 34 16 35
  • 76.09 (n)
rat
(Rattus norvegicus)
Mammalia Cdh26 34
  • 75.77 (n)
dog
(Canis familiaris)
Mammalia CDH26 34 35
  • 74.76 (n)
cow
(Bos Taurus)
Mammalia CDH26 34 35
  • 74.7 (n)
oppossum
(Monodelphis domestica)
Mammalia CDH26 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH26 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH26 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh26 34
  • 53.46 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-96b22.2 34
  • 48.15 (n)
CDH26 35
  • 34 (a)
OneToOne
Species where no ortholog for CDH26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH26 Gene

ENSEMBL:
Gene Tree for CDH26 (if available)
TreeFam:
Gene Tree for CDH26 (if available)

Paralogs for CDH26 Gene

Paralogs for CDH26 Gene

(8) SIMAP similar genes for CDH26 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDH26: view

Variants for CDH26 Gene

Sequence variations from dbSNP and Humsavar for CDH26 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000026614 -- 60,027,205(+) CCTCA(A/G)GGTCA intron-variant
rs1000037434 -- 59,970,536(+) CCAGG(C/T)GCGGT intron-variant
rs1000043285 -- 59,992,018(+) GGGCA(A/G)GTTGG intron-variant
rs1000109487 -- 60,006,164(+) CAGGC(C/T)AGCCT intron-variant
rs1000131931 -- 59,979,274(+) GCTCA(C/T)TGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH26 Gene

Variant ID Type Subtype PubMed ID
esv1009769 CNV deletion 20482838
esv3646235 CNV loss 21293372
nsv817901 CNV loss 17921354

Variation tolerance for CDH26 Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH26 Gene

Disorders for CDH26 Gene

Relevant External Links for CDH26

Genetic Association Database (GAD)
CDH26
Human Genome Epidemiology (HuGE) Navigator
CDH26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH26

No disorders were found for CDH26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDH26 Gene

Publications for CDH26 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Association and interaction analyses of eight genes under asthma linkage peaks. (PMID: 19824886) Ferreira M.A. … Duffy D.L. (Allergy 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation. (PMID: 28051089) Caldwell J.M. … Rothenberg M.E. (Mucosal Immunol 2017) 3 64

Products for CDH26 Gene

Sources for CDH26 Gene

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