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Aliases for CDH24 Gene

Aliases for CDH24 Gene

  • Cadherin 24, Type 2 2 3
  • CDH11L 3 4
  • Cadherin-Like 24 2
  • Cadherin-24 3

External Ids for CDH24 Gene

Summaries for CDH24 Gene

GeneCards Summary for CDH24 Gene

CDH24 (Cadherin 24, Type 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium ion binding and alpha-catenin binding. An important paralog of this gene is CDH19.

UniProtKB/Swiss-Prot for CDH24 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH24 Gene

Genomics for CDH24 Gene

Genomic Location for CDH24 Gene

Start:
23,047,061 bp from pter
End:
23,057,538 bp from pter
Size:
10,478 bases
Orientation:
Minus strand

Genomic View for CDH24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDH24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH24 Gene

Regulatory Elements for CDH24 Gene

Proteins for CDH24 Gene

  • Protein details for CDH24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UP0-CAD24_HUMAN
    Recommended name:
    Cadherin-24
    Protein Accession:
    Q86UP0
    Secondary Accessions:
    • D3DS44
    • Q86UP1
    • Q9NT84

    Protein attributes for CDH24 Gene

    Size:
    819 amino acids
    Molecular mass:
    87752 Da
    Quaternary structure:
    • Associates with alpha-, beta- and delta-catenins

    Alternative splice isoforms for CDH24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH24 Gene

Proteomics data for CDH24 Gene at MOPED

Post-translational modifications for CDH24 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn446, Asn548, and Asn563

Other Protein References for CDH24 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDH24 Gene

Domains for CDH24 Gene

Gene Families for CDH24 Gene

HGNC:
  • MCDH :Cadherins / Major cadherins

UniProtKB/Swiss-Prot:

CAD24_HUMAN
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.:
    • Q86UP0
  • Contains 5 cadherin domains.:
    • Q86UP0
genes like me logo Genes that share domains with CDH24: view

Function for CDH24 Gene

Molecular function for CDH24 Gene

UniProtKB/Swiss-Prot Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.

Gene Ontology (GO) - Molecular Function for CDH24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 12734196
GO:0008013 beta-catenin binding IPI 12734196
GO:0045294 alpha-catenin binding IPI 12734196
GO:0070097 delta-catenin binding IPI 12734196
genes like me logo Genes that share ontologies with CDH24: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDH24 Gene

Localization for CDH24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH24 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH24 Gene COMPARTMENTS Subcellular localization image for CDH24 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CDH24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IDA 12734196
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH24: view

Pathways for CDH24 Gene

genes like me logo Genes that share pathways with CDH24: view

Gene Ontology (GO) - Biological Process for CDH24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0016337 single organismal cell-cell adhesion IDA 12734196
GO:0034329 cell junction assembly TAS --
GO:0034332 adherens junction organization TAS --
GO:0045216 cell-cell junction organization TAS --
genes like me logo Genes that share ontologies with CDH24: view

Compounds for CDH24 Gene

(1) HMDB Compounds for CDH24 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CDH24: view

Transcripts for CDH24 Gene

Unigene Clusters for CDH24 Gene

Cadherin 24, type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for CDH24 Gene

GeneLoc Exon Structure for
CDH24
ECgene alternative splicing isoforms for
CDH24

Expression for CDH24 Gene

mRNA expression in normal human tissues for CDH24 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDH24 Gene

SOURCE GeneReport for Unigene cluster for CDH24 Gene Hs.155912

genes like me logo Genes that share expressions with CDH24: view

Orthologs for CDH24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH24 36
  • 99.23 (n)
  • 98.72 (a)
CDH24 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDH24 36
  • 90.27 (n)
  • 95.26 (a)
CDH24 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH24 36
  • 89.63 (n)
  • 93.47 (a)
CDH24 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh24 36
  • 88.69 (n)
  • 93.34 (a)
Cdh24 16
Cdh24 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDH24 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh24 36
  • 87.92 (n)
  • 94.11 (a)
lizard
(Anolis carolinensis)
Reptilia CDH24 37
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CDH24 (1 of 2) 37
  • 21 (a)
OneToMany
CDH24 (2 of 2) 37
  • 27 (a)
OneToMany
LOC100007192 36
  • 62.79 (n)
  • 60.4 (a)
Species with no ortholog for CDH24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH24 Gene

ENSEMBL:
Gene Tree for CDH24 (if available)
TreeFam:
Gene Tree for CDH24 (if available)

Paralogs for CDH24 Gene

Paralogs for CDH24 Gene

Selected SIMAP similar genes for CDH24 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDH24: view

Variants for CDH24 Gene

Sequence variations from dbSNP and Humsavar for CDH24 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1078451 -- 23,046,883(-) AAGGA(G/T)ATGAT downstream-variant-500B
rs8019032 -- 23,050,213(+) TACAA(G/T)AACCC intron-variant
rs11418548 -- 23,054,929(+) CCGAT(-/G)GGGGG intron-variant
rs11623976 -- 23,049,709(+) TCATC(C/T)CTGTC reference, synonymous-codon
rs11625828 -- 23,054,035(+) AAGCT(C/G)CAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH24 Gene

Variant ID Type Subtype PubMed ID
nsv901491 CNV Loss 21882294

Relevant External Links for CDH24 Gene

HapMap Linkage Disequilibrium report
CDH24

Disorders for CDH24 Gene

No disorders were found for CDH24 Gene.

No data available for UniProtKB/Swiss-Prot for CDH24 Gene

Publications for CDH24 Gene

  1. Characterization of cadherin-24, a novel alternatively spliced type II cadherin. (PMID: 12734196) Katafiasz B.J. … Johnson K.R. (J. Biol. Chem. 2003) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for CDH24 Gene

Sources for CDH24 Gene

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