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Aliases for CDH24 Gene

Aliases for CDH24 Gene

  • Cadherin 24 2 3 5
  • Cadherin 24, Type 2 2 3
  • CDH11L 3 4
  • Cadherin-Like 24 2
  • Cadherin-24 3

External Ids for CDH24 Gene

Previous GeneCards Identifiers for CDH24 Gene

  • GC14M020888
  • GC14M017303
  • GC14M021506
  • GC14M022586
  • GC14M023516
  • GC14M003633

Summaries for CDH24 Gene

GeneCards Summary for CDH24 Gene

CDH24 (Cadherin 24) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Cell junction organization. GO annotations related to this gene include calcium ion binding and alpha-catenin binding. An important paralog of this gene is CDH11.

UniProtKB/Swiss-Prot for CDH24 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH24 Gene

Genomics for CDH24 Gene

Regulatory Elements for CDH24 Gene

Enhancers for CDH24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022996 0.7 FANTOM5 25 +60.6 60611 0.2 PKNOX1 ZNF155 ZNF366 SCRT2 ZNF548 ZNF391 EGR2 OVOL3 ZNF488 TSHZ1 CDH24 ACIN1 PSMB5 PSMB11 PRMT5 C14orf119 CEBPE ENSG00000280129 GC14P023896
GH14F023044 0.2 Ensembl 16 +12.1 12119 1.4 ZNF263 MAZ NFIA HLF JUN ZFP64 ZNF48 TEAD3 IKZF1 MAFK CDH24 RBM23 HAUS4 PSMB11 LOC105370705
GH14F023047 0.4 Ensembl 15.6 +10.3 10319 0.2 POLR2A GLIS1 PRDM10 ZIC2 WT1 CDH24 LOC105370705 PSMB11
GH14F022997 0.5 FANTOM5 15 +60.1 60126 0.4 HIC1 SMARCA4 POLR2A ZNF366 ZNF512 YBX1 ZNF600 CDH24 PSMB5 PSMB11 PRMT5 C14orf119 ACIN1 CEBPE C14orf93 ENSG00000280129 GC14P023896
GH14F022994 1 Ensembl ENCODE 12.3 +62.8 62752 1.1 ELF3 ARID4B ZNF48 RAD21 ZNF143 EGR2 HMG20B ZNF654 REST PPARG PRMT5 CDH24 PSMB5 PSMB11 ACIN1 GC14P023896 ENSG00000280129
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CDH24 on UCSC Golden Path with GeneCards custom track

Promoters for CDH24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000415283 19 1201 HDGF ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 SLC30A9 ZNF143 ZNF207

Genomic Location for CDH24 Gene

Chromosome:
14
Start:
23,047,061 bp from pter
End:
23,057,619 bp from pter
Size:
10,559 bases
Orientation:
Minus strand

Genomic View for CDH24 Gene

Genes around CDH24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH24 Gene

Proteins for CDH24 Gene

  • Protein details for CDH24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UP0-CAD24_HUMAN
    Recommended name:
    Cadherin-24
    Protein Accession:
    Q86UP0
    Secondary Accessions:
    • D3DS44
    • Q86UP1
    • Q9NT84

    Protein attributes for CDH24 Gene

    Size:
    819 amino acids
    Molecular mass:
    87752 Da
    Quaternary structure:
    • Associates with alpha-, beta- and delta-catenins.

    Alternative splice isoforms for CDH24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH24 Gene

Post-translational modifications for CDH24 Gene

  • Glycosylation at Asn 446, Asn 548, and Asn 563
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH24 Gene

Antibody Products

No data available for DME Specific Peptides for CDH24 Gene

Domains & Families for CDH24 Gene

Gene Families for CDH24 Gene

Suggested Antigen Peptide Sequences for CDH24 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UP0

UniProtKB/Swiss-Prot:

CAD24_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH24: view

Function for CDH24 Gene

Molecular function for CDH24 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.

Gene Ontology (GO) - Molecular Function for CDH24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 12734196
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH24: view
genes like me logo Genes that share phenotypes with CDH24: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDH24

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDH24 Gene

Localization for CDH24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH24 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH24 Gene COMPARTMENTS Subcellular localization image for CDH24 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for CDH24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005911 cell-cell junction IDA 12734196
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH24: view

Pathways & Interactions for CDH24 Gene

genes like me logo Genes that share pathways with CDH24: view

Pathways by source for CDH24 Gene

Gene Ontology (GO) - Biological Process for CDH24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0016337 single organismal cell-cell adhesion IDA 12734196
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CDH24: view

No data available for SIGNOR curated interactions for CDH24 Gene

Drugs & Compounds for CDH24 Gene

(1) Drugs for CDH24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH24: view

Transcripts for CDH24 Gene

Unigene Clusters for CDH24 Gene

Cadherin 24, type 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for CDH24 Gene

GeneLoc Exon Structure for
CDH24
ECgene alternative splicing isoforms for
CDH24

Expression for CDH24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDH24 Gene

Protein differential expression in normal tissues from HIPED for CDH24 Gene

This gene is overexpressed in Pancreatic juice (54.3) and Adipocyte (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH24 Gene



Protein tissue co-expression partners for CDH24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDH24 Gene:

CDH24

SOURCE GeneReport for Unigene cluster for CDH24 Gene:

Hs.155912
genes like me logo Genes that share expression patterns with CDH24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDH24 Gene

Orthologs for CDH24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH24 34 35
  • 99.23 (n)
cow
(Bos Taurus)
Mammalia CDH24 34 35
  • 90.27 (n)
oppossum
(Monodelphis domestica)
Mammalia CDH24 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH24 34 35
  • 89.63 (n)
mouse
(Mus musculus)
Mammalia Cdh24 34 16 35
  • 88.69 (n)
rat
(Rattus norvegicus)
Mammalia Cdh24 34
  • 87.92 (n)
lizard
(Anolis carolinensis)
Reptilia CDH24 35
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100007192 34
  • 62.79 (n)
CDH24 (2 of 2) 35
  • 27 (a)
OneToMany
CDH24 (1 of 2) 35
  • 21 (a)
OneToMany
Species where no ortholog for CDH24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH24 Gene

ENSEMBL:
Gene Tree for CDH24 (if available)
TreeFam:
Gene Tree for CDH24 (if available)

Paralogs for CDH24 Gene

Paralogs for CDH24 Gene

(19) SIMAP similar genes for CDH24 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDH24: view

Variants for CDH24 Gene

Sequence variations from dbSNP and Humsavar for CDH24 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1052881 -- 23,058,710(-) CCAGT(C/T)TCTTC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1052884 -- 23,058,708(-) AGTCT(C/T)TTCTG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1052904 -- 23,058,669(-) GTTCC(A/C)CTTTA nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1052922 -- 23,058,658(-) TATCC(A/C)CCTTT nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs10553168 -- 23,050,532(+) CACAC(-/CA)CACAC intron-variant, utr-variant-3-prime

Variation tolerance for CDH24 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDH24 Gene

Disorders for CDH24 Gene

Relevant External Links for CDH24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH24

No disorders were found for CDH24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDH24 Gene

Publications for CDH24 Gene

  1. Characterization of cadherin-24, a novel alternatively spliced type II cadherin. (PMID: 12734196) Katafiasz B.J. … Johnson K.R. (J. Biol. Chem. 2003) 2 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. Frameshift mutations of cadherin genes DCHS2, CDH10 and CDH24 genes in gastric and colorectal cancers with high microsatellite instability. (PMID: 24898286) An C.H. … Lee S.H. (Pathol. Oncol. Res. 2015) 3 64
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for CDH24 Gene

Sources for CDH24 Gene

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