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Aliases for CDH24 Gene

Aliases for CDH24 Gene

  • Cadherin 24 2 3 5
  • Cadherin 24, Type 2 2 3
  • CDH11L 3 4
  • Cadherin-Like 24 2
  • Cadherin-24 3

External Ids for CDH24 Gene

Previous GeneCards Identifiers for CDH24 Gene

  • GC14M020888
  • GC14M017303
  • GC14M021506
  • GC14M022586
  • GC14M023516
  • GC14M003633

Summaries for CDH24 Gene

GeneCards Summary for CDH24 Gene

CDH24 (Cadherin 24) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Cell junction organization. GO annotations related to this gene include calcium ion binding and alpha-catenin binding. An important paralog of this gene is CDH11.

UniProtKB/Swiss-Prot for CDH24 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.

Additional gene information for CDH24 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH24 Gene

Genomics for CDH24 Gene

Regulatory Elements for CDH24 Gene

Enhancers for CDH24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H022976 1.9 FANTOM5 ENCODE dbSUPER 31.2 +77.7 77714 7 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ACIN1 NGDN PRMT5 RBM23 C14orf93 HAUS4 MMP14 LOC102724814 PABPN1 SLC22A17
GH14H022996 1.2 FANTOM5 dbSUPER 25 +60.6 60611 0 PKNOX1 ZSCAN4 ZNF155 EGR1 ZNF366 SCRT2 ZNF548 ZNF391 EGR2 OVOL3 ACIN1 NGDN CDH24 SLC22A17 PABPN1 JPH4 RBM23 PSMB5 PSMB11 PRMT5
GH14H022795 1.5 Ensembl ENCODE dbSUPER 14.5 +260.1 260069 3 PKNOX1 FOXA2 ATF1 TCF12 ATF7 RUNX3 JUNB ZNF592 SSRP1 MIER3 CDH24 PABPN1 OXA1L SLC7A7 MRPL52 MMP14 ENSG00000199716 LRP10 REM2 ENSG00000258458
GH14H023077 1.5 Ensembl ENCODE dbSUPER 11.2 -21.5 -21526 3 PKNOX1 ATF1 ARNT ZNF766 ELK1 FOS ATF7 PAF1 REST ZNF592 CDH24 C14orf119 CEBPE C14orf93 PRMT5 RNU6-1138P SLC7A8 RNF212B
GH14H022835 1.5 FANTOM5 ENCODE dbSUPER 11.1 +219.8 219809 5 ARID4B YBX1 PLRG1 DMAP1 RAD21 YY1 RUNX3 PAF1 KLF11 HMG20B NGDN ACIN1 MRPL52 LOC102724814 PRMT5 EFS RBM23 MMP14 HAUS4 C14orf93
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDH24 on UCSC Golden Path with GeneCards custom track

Promoters for CDH24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066682 -81 1001 HDGF ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 SLC30A9 ZNF207 ZNF143

Genomic Location for CDH24 Gene

Chromosome:
14
Start:
23,047,061 bp from pter
End:
23,057,619 bp from pter
Size:
10,559 bases
Orientation:
Minus strand

Genomic View for CDH24 Gene

Genes around CDH24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH24 Gene

Proteins for CDH24 Gene

  • Protein details for CDH24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UP0-CAD24_HUMAN
    Recommended name:
    Cadherin-24
    Protein Accession:
    Q86UP0
    Secondary Accessions:
    • D3DS44
    • Q86UP1
    • Q9NT84

    Protein attributes for CDH24 Gene

    Size:
    819 amino acids
    Molecular mass:
    87752 Da
    Quaternary structure:
    • Associates with alpha-, beta- and delta-catenins.

    Alternative splice isoforms for CDH24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH24 Gene

Post-translational modifications for CDH24 Gene

  • Glycosylation at posLast=446446, posLast=548548, and Asn563
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH24 Gene

No data available for DME Specific Peptides for CDH24 Gene

Domains & Families for CDH24 Gene

Gene Families for CDH24 Gene

Suggested Antigen Peptide Sequences for CDH24 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UP0

UniProtKB/Swiss-Prot:

CAD24_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH24: view

Function for CDH24 Gene

Molecular function for CDH24 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion.

Phenotypes From GWAS Catalog for CDH24 Gene

Gene Ontology (GO) - Molecular Function for CDH24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 12734196
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH24: view
genes like me logo Genes that share phenotypes with CDH24: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDH24

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CDH24
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDH24 Gene

Localization for CDH24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH24 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH24 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CDH24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005911 cell-cell junction IDA 12734196
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH24: view

Pathways & Interactions for CDH24 Gene

genes like me logo Genes that share pathways with CDH24: view

Pathways by source for CDH24 Gene

Gene Ontology (GO) - Biological Process for CDH24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0016337 single organismal cell-cell adhesion IDA --
GO:0034332 adherens junction organization TAS --
GO:0098609 cell-cell adhesion IDA 12734196
genes like me logo Genes that share ontologies with CDH24: view

No data available for SIGNOR curated interactions for CDH24 Gene

Drugs & Compounds for CDH24 Gene

(1) Drugs for CDH24 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH24: view

Transcripts for CDH24 Gene

Unigene Clusters for CDH24 Gene

Cadherin 24, type 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CDH24
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CDH24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for CDH24 Gene

GeneLoc Exon Structure for
CDH24
ECgene alternative splicing isoforms for
CDH24

Expression for CDH24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDH24 Gene

Protein differential expression in normal tissues from HIPED for CDH24 Gene

This gene is overexpressed in Pancreatic juice (54.3) and Adipocyte (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH24 Gene



Protein tissue co-expression partners for CDH24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDH24 Gene:

CDH24

SOURCE GeneReport for Unigene cluster for CDH24 Gene:

Hs.155912
genes like me logo Genes that share expression patterns with CDH24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH24 Gene

Orthologs for CDH24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH24 33 34
  • 99.23 (n)
cow
(Bos Taurus)
Mammalia CDH24 33 34
  • 90.27 (n)
oppossum
(Monodelphis domestica)
Mammalia CDH24 34
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH24 33 34
  • 89.63 (n)
mouse
(Mus musculus)
Mammalia Cdh24 33 16 34
  • 88.69 (n)
rat
(Rattus norvegicus)
Mammalia Cdh24 33
  • 87.92 (n)
lizard
(Anolis carolinensis)
Reptilia CDH24 34
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100007192 33
  • 62.79 (n)
CDH24 (2 of 2) 34
  • 27 (a)
OneToMany
CDH24 (1 of 2) 34
  • 21 (a)
OneToMany
Species where no ortholog for CDH24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH24 Gene

ENSEMBL:
Gene Tree for CDH24 (if available)
TreeFam:
Gene Tree for CDH24 (if available)

Paralogs for CDH24 Gene

Paralogs for CDH24 Gene

(19) SIMAP similar genes for CDH24 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDH24: view

Variants for CDH24 Gene

Sequence variations from dbSNP and Humsavar for CDH24 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000145646 -- 23,058,398(+) GTCAG(A/G)GCCAA downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000365059 -- 23,058,214(+) CCGCC(C/T)CCTGG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000554642 -- 23,053,516(+) GGGGA(A/G)TCCAG reference, synonymous-codon
rs1001095751 -- 23,047,946(+) CTGCC(C/G)CCCCC utr-variant-3-prime
rs1001112030 -- 23,052,243(+) GCCTA(A/G)GGGAC intron-variant

Variation tolerance for CDH24 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.27; 62.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CDH24 Gene

Disorders for CDH24 Gene

Relevant External Links for CDH24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH24

No disorders were found for CDH24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDH24 Gene

Publications for CDH24 Gene

  1. Characterization of cadherin-24, a novel alternatively spliced type II cadherin. (PMID: 12734196) Katafiasz BJ … Johnson KR (The Journal of biological chemistry 2003) 2 3 4 60
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Frameshift mutations of cadherin genes DCHS2, CDH10 and CDH24 genes in gastric and colorectal cancers with high microsatellite instability. (PMID: 24898286) An CH … Lee SH (Pathology oncology research : POR 2015) 3 60
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 60

Products for CDH24 Gene

Sources for CDH24 Gene

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