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Aliases for CDH22 Gene

Aliases for CDH22 Gene

  • Cadherin 22 2 3 5
  • Pituitary And Brain Cadherin 3 4
  • Cadherin 22, Type 2 2 3
  • Cadherin-Like 22 2 3
  • PB-Cadherin 3 4
  • C20orf25 3 4
  • Ortholog Of Rat PB-Cadherin 3
  • Cadherin-22 3
  • DJ998H6.1 3

External Ids for CDH22 Gene

Previous HGNC Symbols for CDH22 Gene

  • C20orf25

Previous GeneCards Identifiers for CDH22 Gene

  • GC20M044530
  • GC20M045440
  • GC20M045487
  • GC20M044235
  • GC20M044802
  • GC20M041543

Summaries for CDH22 Gene

Entrez Gene Summary for CDH22 Gene

  • This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH22 Gene

CDH22 (Cadherin 22) is a Protein Coding gene. Among its related pathways are WNT Signaling and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH7.

UniProtKB/Swiss-Prot for CDH22 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH22 Gene

Genomics for CDH22 Gene

Regulatory Elements for CDH22 Gene

Enhancers for CDH22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CDH22 on UCSC Golden Path with GeneCards custom track

Promoters for CDH22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CDH22 Gene

Chromosome:
20
Start:
46,173,733 bp from pter
End:
46,308,829 bp from pter
Size:
135,097 bases
Orientation:
Minus strand

Genomic View for CDH22 Gene

Genes around CDH22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH22 Gene

Proteins for CDH22 Gene

  • Protein details for CDH22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJ99-CAD22_HUMAN
    Recommended name:
    Cadherin-22
    Protein Accession:
    Q9UJ99
    Secondary Accessions:
    • B9EGK7
    • O43205

    Protein attributes for CDH22 Gene

    Size:
    828 amino acids
    Molecular mass:
    89091 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDH22 Gene

Post-translational modifications for CDH22 Gene

  • Glycosylation at Asn 162, Asn 466, and Asn 612
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH22 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDH22 Gene

Domains & Families for CDH22 Gene

Gene Families for CDH22 Gene

Suggested Antigen Peptide Sequences for CDH22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJ99

UniProtKB/Swiss-Prot:

CAD22_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH22: view

Function for CDH22 Gene

Molecular function for CDH22 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity).

Gene Ontology (GO) - Molecular Function for CDH22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDH22: view

Phenotypes for CDH22 Gene

genes like me logo Genes that share phenotypes with CDH22: view

Animal Models for CDH22 Gene

MGI Knock Outs for CDH22:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDH22

CRISPR Products

miRNA for CDH22 Gene

miRTarBase miRNAs that target CDH22

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH22 Gene

Localization for CDH22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH22 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH22 Gene COMPARTMENTS Subcellular localization image for CDH22 gene
Compartment Confidence
plasma membrane 5
lysosome 2
vacuole 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDH22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH22: view

Pathways & Interactions for CDH22 Gene

genes like me logo Genes that share pathways with CDH22: view

Pathways by source for CDH22 Gene

Interacting Proteins for CDH22 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361336%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000346155%0d%0a9606.ENSP00000346155%0d%0a9606.ENSP00000344456%0d%0a9606.ENSP00000311113%0d%0a
Selected Interacting proteins: ENSP00000361336 Q9UJ99-CAD22_HUMAN for CDH22 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CDH22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007420 brain development IEA --
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
genes like me logo Genes that share ontologies with CDH22: view

No data available for SIGNOR curated interactions for CDH22 Gene

Drugs & Compounds for CDH22 Gene

(1) Drugs for CDH22 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH22: view

Transcripts for CDH22 Gene

Unigene Clusters for CDH22 Gene

Cadherin 22, type 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH22 Gene

No ASD Table

Relevant External Links for CDH22 Gene

GeneLoc Exon Structure for
CDH22
ECgene alternative splicing isoforms for
CDH22

Expression for CDH22 Gene

mRNA expression in normal human tissues for CDH22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH22 Gene

This gene is overexpressed in Brain - Cerebellum (x11.2), Brain - Cerebellar Hemisphere (x10.5), Brain - Cortex (x5.6), Brain - Frontal Cortex (BA9) (x4.6), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for CDH22 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CDH22 Gene



Protein tissue co-expression partners for CDH22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDH22 Gene:

CDH22

SOURCE GeneReport for Unigene cluster for CDH22 Gene:

Hs.472861
genes like me logo Genes that share expression patterns with CDH22: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CDH22 Gene

Orthologs for CDH22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDH22 34
  • 91.91 (n)
  • 94.78 (a)
CDH22 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH22 34
  • 92.85 (n)
  • 96.36 (a)
CDH22 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh22 34
  • 88.45 (n)
  • 94.45 (a)
Cdh22 16
Cdh22 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDH22 34
  • 99.1 (n)
  • 99.15 (a)
CDH22 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh22 34
  • 87.88 (n)
  • 94.2 (a)
oppossum
(Monodelphis domestica)
Mammalia CDH22 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH22 34
  • 77.73 (n)
  • 82.69 (a)
CDH22 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh22 34
  • 67.33 (n)
  • 75.17 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01034923.1 35
  • 69 (a)
OneToOne
Species where no ortholog for CDH22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH22 Gene

ENSEMBL:
Gene Tree for CDH22 (if available)
TreeFam:
Gene Tree for CDH22 (if available)

Paralogs for CDH22 Gene

Paralogs for CDH22 Gene

genes like me logo Genes that share paralogs with CDH22: view

Variants for CDH22 Gene

Sequence variations from dbSNP and Humsavar for CDH22 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs909896 -- 46,304,658(-) CCCAC(A/G)TTTCC intron-variant
rs966567 -- 46,238,586(-) aggaa(C/G)agatt intron-variant
rs1467401 -- 46,189,963(-) TGTTT(A/T)AAAAA intron-variant
rs733379 -- 46,227,824(-) ACTTG(C/T)GCCAC intron-variant
rs1883837 -- 46,186,661(+) TGCCC(A/G)CCTTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CDH22 Gene

Variant ID Type Subtype PubMed ID
dgv2434e59 CNV duplication 20981092
esv27173 CNV loss 19812545
esv2758796 CNV loss 17122850
esv3446151 CNV duplication 20981092
esv3645950 CNV loss 21293372
esv3645951 CNV loss 21293372
esv3645952 CNV gain 21293372
nsv1057686 CNV loss 25217958
nsv3394 CNV insertion 18451855
nsv471878 CNV novel sequence insertion 20440878
nsv833993 CNV gain 17160897
nsv9810 CNV gain 18304495

Variation tolerance for CDH22 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.64; 65.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH22 Gene

Disorders for CDH22 Gene

Relevant External Links for CDH22

Genetic Association Database (GAD)
CDH22
Human Genome Epidemiology (HuGE) Navigator
CDH22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH22

No disorders were found for CDH22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDH22 Gene

Publications for CDH22 Gene

  1. Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. (PMID: 18602983) Bento J.L. … Mychaleckyj J.C. (Genomics 2008) 3 22 46 65
  2. Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. (PMID: 20650312) Lewis J.P. … Bowden D.W. (Genomics 2010) 3 46 65
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 65
  4. Molecular cloning and characterization of a newly identified member of the cadherin family, PB-cadherin. (PMID: 8626716) Sugimoto K. … Nakamura T. (J. Biol. Chem. 1996) 2 3 65
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3 65

Products for CDH22 Gene

Sources for CDH22 Gene

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