Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDH22 Gene

protein-coding   GIFtS: 50
GCID: GC20M044802

cadherin 22, type 2

(Previous name: cadherin-like 22 )
(Previous symbol: C20orf25)
 Explore 1 disease affiliated with
CDH22 via our new
 Human Malady Compendium 
Biological research products
for CDH22
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cadherin 22, Type 21 2     Pituitary And Brain Cadherin2 3
C20orf251 2 3     PB-Cadherin1
Cadherin-Like 221 2     Cadherin-221
DJ998H6.11     Ortholog Of Rat PB-Cadherin2

External Ids:    HGNC: 132511   Entrez Gene: 644052   Ensembl: ENSG000001496547   OMIM: 6099205   UniProtKB: Q9UJ993   

Export aliases for CDH22 gene to outside databases

Previous GC identifers: GC20M044530 GC20M045440 GC20M045487 GC20M044235 GC20M041543


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDH22:
This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains and a
cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed predominantly in
the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and
tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine
organs. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAD22_HUMAN, Q9UJ99
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a
homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDH22 gene promoter:
         GR   TBP   p53   Pax-5   GR-beta   HSF1 (long)   Olf-1   YY1   TFIID   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDH22 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDH22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDH22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.1

CDH22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH22 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044802:  view genomic region     (about GC identifiers)

Start:
44,802,372 bp from pter      End:
44,937,137 bp from pter
Size:
134,766 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAD22_HUMAN, Q9UJ99 (See protein sequence)
Recommended Name: Cadherin-22 precursor  
Size: 828 amino acids; 89091 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: B9EGK7 O43205

Explore the universe of human proteins at neXtProt for CDH22: NX_Q9UJ99

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UJ99

  • CDH22 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_067071.1  
    ENSEMBL proteins: 
     ENSP00000361336   ENSP00000437790  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for CDH22 
    GenScript Custom Purified and Recombinant Proteins Services for CDH22
    Novus Biologicals CDH22 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDH22

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    CDH22 for ontologies           About GeneDecksing



    CDH22 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CDH22 
    GenScript Custom Superior Antibodies Services for CDH22
    Novus Biologicals CDH22 Antibodies
    Search for Antibodies for CDH22 at Abcam  
    Uscn Antibodies for CDH22
    Search ThermoFisher Antibodies for CDH22

    Assay Products for CDH22: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDH22
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CDH22


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CDH22 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q9UJ99

    ProtoNet protein and cluster: Q9UJ99

    2 Blocks protein families:
    IPB000233 Cadherin cytoplasmic region
    IPB002126 Cadherin


    UniProtKB/Swiss-Prot: CAD22_HUMAN, Q9UJ99
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections,
    imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 5 cadherin domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CAD22_HUMAN, Q9UJ99
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a
    homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
    PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity)

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: CDH22
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDH22
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CDH22 (see all 18):
    hsa-miR-98 hsa-miR-455-5p hsa-let-7d hsa-miR-330-5p hsa-let-7c hsa-let-7i hsa-miR-1227 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCDH22 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDH22 (see all 7)
    OriGene shRNA RFP: CDH22
    OriGene siRNA: CDH22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDH22

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDH22

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDH22 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDH22
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CDH22 (NM_021248)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDH22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH22 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDH22
    Search LifeMap BioReagents cell lines for CDH22

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH22

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--


    CDH22 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Cdh22tm1.1Hsav for CDH22
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Cdh22):
     no phenotypic analysis 

    CDH22 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1WNT Signaling
    WNT Signaling1.00
    2S-1P Stimulated Signaling
    S-1P Stimulated Signaling1.00
    3G12-G13 in Cellular Signaling
    G12-G13 in Cellular Signaling1.00
    4Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    5Rho Family GTPases
    ILK Signaling0.45

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDH22
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    WNT Signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDH22

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CDH22 (ENSP000003613364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PKP4ENSP000003744094STRING: ENSP00000374409
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion IEA--


    CDH22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDH22

    1 HMDB Compound for CDH22    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CDH22 / CAD22 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDH22 gene: 
    NM_021248.2  

    Unigene Cluster for CDH22:

    Cadherin 22, type 2
    Hs.472861  [show with all ESTs]
    Unigene Representative Sequence: NM_021248
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372262(uc002xrm.2 uc010ghk.1) ENST00000474438(uc002xrn.2)
    ENST00000537909

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: CDH22
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDH22
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CDH22 (see all 18):
    hsa-miR-98 hsa-miR-455-5p hsa-let-7d hsa-miR-330-5p hsa-let-7c hsa-let-7i hsa-miR-1227 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCDH22 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDH22 (see all 7)
    OriGene shRNA RFP: CDH22
    OriGene siRNA: CDH22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDH22
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDH22 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDH22
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CDH22 (NM_021248)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDH22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH22 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDH22
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDH22
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDH22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDH22

    Additional cDNA sequence: 

    AF035300.1 AK289584.1 BC031232.1 BC039056.1 BC136526.1 

    3 DOTS entries:

    DT.407017  DT.99967924  DT.97806510 

    24/26 AceView cDNA sequences (see all 26):

    BE218150 BQ086149 BQ888257 BC039056 BQ102264 AF035300 AA029635 NM_021248 
    CK823196 BU071193 BE327419 BU070529 BU743058 BQ101229 BU070766 BC031232 
    AI630817 BG717973 BQ100918 BU073201 AA029636 BU150580 BX091010 BM931192 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDH22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGTGGTGTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CDH22 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Cartilage-like cells (Differentiation of s...)Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CDH22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDH22

    SOURCE GeneReport for Unigene cluster: Hs.472861
        SABiosciences Custom PCR Arrays for CDH22
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDH22
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDH22
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDH22
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDH22
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CDH22 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CDH221 cadherin 22, type 2 78.37(n)
    83.23(a)
      419305  XM_417477.2  XP_417477.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDH226
    --
    --
    78(a)
    62(a)
    possible ortholog
    1 ↔ 1
    GL343774.1(41508-49393)
    GL344019.1(102710-105881)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01034923.16
    --
    69(a)
    1 ↔ 1
    6(56702053-56827173)


    ENSEMBL Gene Tree for CDH22 (if available)
    TreeFam Gene Tree for CDH22 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDH22 gene
    CDH42  CDH182  DSG42  CDH32  CDH102  CDH112  CDH12  CDH62  
    DSC22  CDH82  CDH202  DSC12  CDH192  DSG12  CDH72  DSG22  
    CDH92  CDH122  CDH262  DSC32  CDH22  CDH242  CDH152  CDH52  
    DSG32  
    18/34 SIMAP similar genes for CDH22 using alignment to 2 protein entries:     CAD22_HUMAN (see all proteins) (see all similar genes):
    CDH7    Nbla04261    CDH9    CDH10    CDH18    CDH8
    CDH20    CDH6    CDH11    CDH12    CDH19    CDH24
    CDH13    FAT4    FAT3    CDH4    CDH2    CDH17

    CDH22 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1450 NCBI SNPs in CDH22 are shown (see all 1450    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1179335351,2
    F,--44801915(+) TGGGCG/ATGGGG 1 -- ds50011Minor allele frequency- A:0.02EA 120
    rs1122887071,2
    --44801943(+) TAACCG/ATATCT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1817870291,2
    --44802010(+) TTAATC/TTGGGA 1 -- ds50010--------
    rs1381185301,2
    C,--44802019(+) GATCC-/ATGAG 
     TGGGAAG
    ACTGA
    1 -- ds50010--------
    rs24257661,2
    C,F,A,H,--44802021(+) TCCATG/CAGTGG 1 -- ds50013Minor allele frequency- C:0.50NA 6
    rs358459421,2
    C,--44802028(+) TGGGA-/TAGACT 1 -- ds50010--------
    rs1497676871,2
    --44802091(+) CTGACA/CCCTCT 1 -- ds50010--------
    rs1173928561,2
    --44802295(+) GAAAAG/AGGGAA 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs2020411061,2
    C--44802613(+) ACGGGC/TCACAG 1 -- ut310--------
    rs1457752241,2
    --44802729(+) TGCTTA/CGTAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CDH22 (44802372 - 44937137 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CDH22
         1 CNV: 4102

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDH22
    DNA2.0 Custom Variant and Variant Library Synthesis for CDH22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CDH22 for disorders           About GeneDecksing

    OMIM gene information: 609920    OMIM disorders: --

    1 disease for CDH22:    About MalaCards
    colorectal cancer

    Human Genome Epidemiology (HuGE) Navigator: CDH22 (2 documents)

    Export disorders for CDH22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDH22 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CDH22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    2. Molecular cloning and characterization of a newly identified member of the cadherin family, PB-cadherin. (PubMed id 8626716)1, 3 Sugimoto K....Nakamura T. (1996)
    3. Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. (PubMed id 18602983)1, 9 Bento J.L....Mychaleckyj J.C. (2008)
    4. Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. (PubMed id 20650312)1 Lewis J.P....Bowden D.W. (2010)
    5. Over-expression of CDH22 is associated with tumor pro gression in colorectal cancer. (PubMed id 19546606)1 Zhou J....Ding Y. (2009)
    6. PRL-3 promotes epithelial mesenchymal transition by r egulating cadherin directly. (PubMed id 19440036)1 Liu Y....Li J. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Expression of a novel factor, short-type PB-cadherin, in Sertoli cells and spermatogenic stem cells of the neonatal rat testis. (PubMed id 12630923)1 Wu J....Orth J.M. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64405 HGNC: 13251 AceView: CDH22 Ensembl:ENSG00000149654 euGenes: HUgn64405
    ECgene: CDH22 H-InvDB: CDH22

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDH22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDH22 gene:
    Search GeneIP for patents involving CDH22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CDH22  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDH22   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDH22  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CDH22   OriGene 3'-UTR Clone for CDH22  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDH22   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDH22  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDH22   OriGene Custom Protein Services for CDH22  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDH22
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDH22
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDH22
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDH22
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDH22
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDH22
     GenScript Custom Purified and Recombinant Proteins Services for CDH22 GenScript cDNA clones with any tag delivered in your preferred vector for CDH22
     GenScript Custom Assay Services for CDH22 GenScript Custom Superior Antibodies Services for CDH22
     GenScript Custom overexpressing Cell Line Services for CDH22 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CDH22 promoter
     Search Chromatin IP Primers for CDH22
     RT2 qPCR Primer Assay in human, mouse, rat CDH22
     GNC Network for CDH22
     SABiosciences PCR Arrays including human, mouse, rat CDH22
     Search Tocris compounds for CDH22
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CDH22 antibodies
     CDH22 proteins
     Search for Antibodies for CDH22 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CDH22
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CDH22 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CDH22
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH22
     SwitchGear 3'UTR luciferase reporter plasmids for CDH22
     SwitchGear Promoter luciferase reporter plasmids for CDH22
     Search ThermoFisher Antibodies for CDH22
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH22
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDH22 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4