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CDH22 Gene

protein-coding   GIFtS: 50
GCID: GC20M044802

Cadherin 22, Type 2

(Previous name: cadherin-like 22)
(Previous symbol: C20orf25)
  Search for CDH22
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cadherin 22, Type 21 2     PB-cadherin2 3
C20orf251 2 3     cadherin-222
Cadherin-Like 221 2     dJ998H6.12
Pituitary And Brain Cadherin2 3     Ortholog Of Rat PB-Cadherin2

External Ids:    HGNC: 132511   Entrez Gene: 644052   Ensembl: ENSG000001496547   OMIM: 6099205   UniProtKB: Q9UJ993   

Export aliases for CDH22 gene to outside databases

Previous GC identifers: GC20M044530 GC20M045440 GC20M045487 GC20M044235 GC20M041543


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDH22 Gene:
This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains
and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed
predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in
morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain
and neuroendocrine organs. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDH22 Gene:
CDH22 (cadherin 22, type 2) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH18.

UniProtKB/Swiss-Prot: CAD22_HUMAN, Q9UJ99
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell
types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDH22 gene promoter:
         GR   TBP   p53   Pax-5   GR-beta   HSF1 (long)   Olf-1   YY1   TFIID   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDH22 promoter sequence
   Search Chromatin IP Primers for CDH22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDH22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.1

CDH22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH22 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044802:  view genomic region     (about GC identifiers)

Start:
44,802,372 bp from pter      End:
44,937,137 bp from pter
Size:
134,766 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAD22_HUMAN, Q9UJ99 (See protein sequence)
Recommended Name: Cadherin-22 precursor  
Size: 828 amino acids; 89091 Da
Secondary accessions: B9EGK7 O43205

Explore the universe of human proteins at neXtProt for CDH22: NX_Q9UJ99

Explore proteomics data for CDH22 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn162, Asn466, Asn612
  • Modification sites at PhosphoSitePlus

  • See CDH22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067071.1  
    ENSEMBL proteins: 
     ENSP00000361336   ENSP00000437790  

    CDH22 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CDH22

     
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    LSBio Antibodies in human, mouse, rat for CDH22

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    Search eBioscience for ELISAs for CDH22 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MCDH: Cadherins / Major cadherins

    5 InterPro protein domains:
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR027397 Catenin_binding_dom
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q9UJ99

    ProtoNet protein and cluster: Q9UJ99

    2 Blocks protein domains:
    IPB000233 Cadherin cytoplasmic region
    IPB002126 Cadherin


    UniProtKB/Swiss-Prot: CAD22_HUMAN, Q9UJ99
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the
    connections, imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 5 cadherin domains


    Find genes that share domains with CDH22           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAD22_HUMAN, Q9UJ99
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
    a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell
    types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with CDH22           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Cdh22):
     no phenotypic analysis 

    Find genes that share phenotypes with CDH22           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdh22tm1.1Hsav for CDH22

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDH22
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDH22

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDH22
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDH22

    miRNA
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    Block miRNA regulation of human, mouse, rat CDH22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDH22 (see all 18):
    hsa-miR-98 hsa-miR-455-5p hsa-let-7d hsa-miR-330-5p hsa-let-7c hsa-let-7i hsa-miR-1227 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCDH22 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDH22

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    GenScript: all cDNA clones in your preferred vector: CDH22 (NM_021248)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH22

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAD22_HUMAN, Q9UJ99: Cell membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    lysosome2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CDH22           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDH22 About    
    See pathways by source

    SuperPathContained pathways About
    1Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    2ERK Signaling
    ILK Signaling0.49
    3WNT Signaling
    WNT Signaling
    4S-1P Stimulated Signaling
    S-1P Stimulated Signaling
    5G12-G13 in Cellular Signaling
    G12-G13 in Cellular Signaling

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDH22
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    WNT Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDH22
    Interactions:

        GeneGlobe Interaction Network for CDH22

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CDH22 (ENSP000003613364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PKP4ENSP000003744094STRING: ENSP00000374409
    CTNND1ENSP000003820044STRING: ENSP00000382004
    ARVCFENSP000002632074STRING: ENSP00000263207
    CTNND2ENSP000003071344STRING: ENSP00000307134
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion IEA--
    GO:0007420brain development IEA--
    GO:0016339calcium-dependent cell-cell adhesion IEA--

    Find genes that share ontologies with CDH22           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDH22 (CAD22)

    1 HMDB Compound for CDH22    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDH22 gene: 
    NM_021248.2  

    Unigene Cluster for CDH22:

    Cadherin 22, type 2
    Hs.472861  [show with all ESTs]
    Unigene Representative Sequence: NM_021248
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372262(uc002xrm.2 uc010ghk.1) ENST00000474438(uc002xrn.2)
    ENST00000537909
    miRNA
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    Block miRNA regulation of human, mouse, rat CDH22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDH22 (see all 18):
    hsa-miR-98 hsa-miR-455-5p hsa-let-7d hsa-miR-330-5p hsa-let-7c hsa-let-7i hsa-miR-1227 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCDH22 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDH22
    Predesigned siRNA for gene silencing in human, mouse, rat CDH22
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    GenScript: all cDNA clones in your preferred vector: CDH22 (NM_021248)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH22
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CDH22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDH22
      QuantiTect SYBR Green Assays in human, mouse, rat CDH22
      QuantiFast Probe-based Assays in human, mouse, rat CDH22

    Additional mRNA sequence: 

    AF035300.1 AK289584.1 BC031232.1 BC039056.1 BC136526.1 

    3 DOTS entries:

    DT.407017  DT.99967924  DT.97806510 

    Selected AceView cDNA sequences (see all 26):

    BU071193 BC039056 AF035300 BU070529 BQ086149 BQ888257 BQ102264 CK823196 
    NM_021248 BE218150 BE327419 AA029635 BQ101229 BU743058 BU073201 AI630817 
    BQ100918 BC031232 BU070766 AA029636 BG717973 BU150580 BX091010 BM931192 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDH22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTGGTGTC
    CDH22 Expression
    About this image


    CDH22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)
             Cerebellum
    CDH22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDH22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.472861
        Custom PCR Arrays for CDH22
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDH22 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdh221 , 5 cadherin 221, 5 88.45(n)1
    94.45(a)1
      2 (85.43 cM)5
    1040101  NM_174988.31  NP_778153.21 
     1651115075 
    chicken
    (Gallus gallus)
    Aves CDH221 cadherin 22, type 2 77.73(n)
    82.69(a)
      419305  XM_417477.3  XP_417477.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdh221 cadherin 22, type 2 67.33(n)
    75.17(a)
      100498457  XM_002932526.2  XP_002932572.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01034923.16
    Uncharacterized protein
    69(a)
    1 ↔ 1
    6(56702053-56827173) ENSDARG00000075268


    ENSEMBL Gene Tree for CDH22 (if available)
    TreeFam Gene Tree for CDH22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDH22 gene
    CDH182  CDH192  CDH102  CDH112  CDH72  CDH92  CDH62  CDH122  
    CDH82  CDH242  CDH202  CDH52  
    Selected SIMAP similar genes for CDH22 using alignment to 2 protein entries:     CAD22_HUMAN (see all proteins) (see all similar genes):
    CDH7    Nbla04261    CDH9    CDH10    CDH18    CDH8
    CDH20    CDH6    CDH11    CDH12    CDH19    CDH24
    FAT4    FAT3    CDH4    CDH2    CDH17    ME5

    Find genes that share paralogs with CDH22           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDH22 (see all 2824)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349618481,2
    C--41598981(+) AGTGG-/C/GCCCCC 1 -- int10--------
    rs1179335351,2
    F--44801915(+) TGGGCG/ATGGGG 1 -- ds50011Minor allele frequency- A:0.02EA 120
    rs1122887071,2
    C,F--44801943(+) TAACCG/ATATCT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1817870291,2
    --44802010(+) TTAATC/TTGGGA 1 -- ds50010--------
    rs1381185301,2
    C--44802019(+) GATCC-/ATGAG 
     TGGGAAG
    ACTGA
    1 -- ds50010--------
    rs24257661,2
    C,F,A,H--44802021(+) TCCATG/CAGTGG 1 -- ds50013Minor allele frequency- C:0.50NA 6
    rs358459421,2
    C--44802028(+) TGGGA-/TCGACT 1 -- ds50010--------
    rs669780671,2
    C--44802029(+) GGGAA-/TGACTG 1 -- ds50010--------
    rs1497676871,2
    --44802091(+) CTGACA/CCCTCT 1 -- ds50010--------
    rs1173928561,2
    F--44802295(+) GAAAAG/AGGGAA 1 -- ds50011Minor allele frequency- A:0.01EA 120

    HapMap Linkage Disequilibrium report for CDH22 (44802372 - 44937137 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CDH22:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833993CNV Gain17160897
    dgv1330e1CNV Complex17122850
    dgv1329e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDH22
    DNA2.0 Custom Variant and Variant Library Synthesis for CDH22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609920    OMIM disorders: --


    Find genes that share disorders with CDH22           About GenesLikeMe

    Genetic Association Database (GAD): CDH22
    Human Genome Epidemiology (HuGE) Navigator: CDH22 (2 documents)

    Export disorders for CDH22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDH22 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CDH22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1. (PubMed id 18602983)1, 4, 9 Bento J.L....Mychaleckyj J.C. (Genomics 2008)
    2. Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans. (PubMed id 20650312)1, 4 Lewis J.P....Bowden D.W. (Genomics 2010)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    4. Molecular cloning and characterization of a newly identified member of the cadherin family, PB-cadherin. (PubMed id 8626716)1, 3 Sugimoto K....Nakamura T. (J. Biol. Chem. 1996)
    5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    6. Over-expression of CDH22 is associated with tumor progression in colorectal cancer. (PubMed id 19546606)1 Zhou J....Ding Y. (Tumour Biol. 2009)
    7. PRL-3 promotes epithelial mesenchymal transition by regulating cadherin directly. (PubMed id 19440036)1 Liu Y....Li J. (amp 2009)
    8. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PubMed id 18854154)1 KAPnig R....Chanda S.K. (Cell 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Expression of a novel factor, short-type PB-cadherin, in Sertoli cells and spermatogenic stem cells of the neonatal rat testis. (PubMed id 12630923)1 Wu J....Orth J.M. (J. Endocrinol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64405 HGNC: 13251 AceView: CDH22 Ensembl:ENSG00000149654 euGenes: HUgn64405
    ECgene: CDH22 H-InvDB: CDH22

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDH22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDH22 gene:
    Search GeneIP for patents involving CDH22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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