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Aliases for CDH20 Gene

Aliases for CDH20 Gene

  • Cadherin 20, Type 2 2 3
  • CDH7L3 3 4
  • Cadherin-20 3
  • Cdh7 3

External Ids for CDH20 Gene

Previous GeneCards Identifiers for CDH20 Gene

  • GC18P058988
  • GC18P059130
  • GC18P057306
  • GC18P057308
  • GC18P055867

Summaries for CDH20 Gene

Entrez Gene Summary for CDH20 Gene

  • This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH20 Gene

CDH20 (Cadherin 20, Type 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH19.

UniProtKB/Swiss-Prot for CDH20 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH20 Gene

Genomics for CDH20 Gene

Genomic Location for CDH20 Gene

Start:
61,333,582 bp from pter
End:
61,569,882 bp from pter
Size:
236,301 bases
Orientation:
Plus strand

Genomic View for CDH20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDH20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH20 Gene

Proteins for CDH20 Gene

  • Protein details for CDH20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBT6-CAD20_HUMAN
    Recommended name:
    Cadherin-20
    Protein Accession:
    Q9HBT6
    Secondary Accessions:
    • Q495S3

    Protein attributes for CDH20 Gene

    Size:
    801 amino acids
    Molecular mass:
    88993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDH20 Gene

Proteomics data for CDH20 Gene at MOPED

Post-translational modifications for CDH20 Gene

  • Glycosylation at Asn261, Asn420, Asn461, and Asn542
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDH20 Gene

Domains for CDH20 Gene

Gene Families for CDH20 Gene

HGNC:
  • MCDH :Cadherins / Major cadherins

Suggested Antigen Peptide Sequences for CDH20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBT6

UniProtKB/Swiss-Prot:

CAD20_HUMAN :
  • Q9HBT6
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH20: view

Function for CDH20 Gene

Molecular function for CDH20 Gene

UniProtKB/Swiss-Prot Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Ontology (GO) - Molecular Function for CDH20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDH20: view

miRNA for CDH20 Gene

miRTarBase miRNAs that target CDH20

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDH20 Gene

Localization for CDH20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH20 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH20 Gene COMPARTMENTS Subcellular localization image for CDH20 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDH20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH20: view

Pathways for CDH20 Gene

genes like me logo Genes that share pathways with CDH20: view

Pathways by source for CDH20 Gene

Interacting Proteins for CDH20 Gene

Gene Ontology (GO) - Biological Process for CDH20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with CDH20: view

Compounds for CDH20 Gene

(1) HMDB Compounds for CDH20 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CDH20: view

Transcripts for CDH20 Gene

mRNA/cDNA for CDH20 Gene

(9) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDH20 Gene

Cadherin 20, type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH20 Gene

No ASD Table

Relevant External Links for CDH20 Gene

GeneLoc Exon Structure for
CDH20
ECgene alternative splicing isoforms for
CDH20

Expression for CDH20 Gene

mRNA expression in normal human tissues for CDH20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH20 Gene

This gene is overexpressed in Brain - Amygdala (5.4), Brain - Caudate (basal ganglia) (5.0), Brain - Spinal cord (cervical c-1) (4.9), Brain - Nucleus accumbens (basal ganglia) (4.5), Brain - Substantia nigra (4.5), Brain - Hippocampus (4.3), and Brain - Putamen (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDH20 Gene

SOURCE GeneReport for Unigene cluster for CDH20 Gene Hs.671510

mRNA Expression by UniProt/SwissProt for CDH20 Gene

Q9HBT6-CAD20_HUMAN
Tissue specificity: Expressed in placenta, adult brain, and fetal brain
genes like me logo Genes that share expressions with CDH20: view

Orthologs for CDH20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH20 35
  • 99.38 (n)
  • 99.88 (a)
CDH20 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDH20 35
  • 89.89 (n)
  • 96.38 (a)
CDH20 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH20 35
  • 92.68 (n)
  • 97.13 (a)
CDH20 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh20 35
  • 89.76 (n)
  • 96.25 (a)
Cdh20 16
Cdh20 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDH20 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH20 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh20 35
  • 89.39 (n)
  • 95.51 (a)
chicken
(Gallus gallus)
Aves CDH20 35
  • 81.43 (n)
  • 88.96 (a)
CDH20 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH20 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.153 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh20 35
  • 72.61 (n)
  • 79.87 (a)
Species with no ortholog for CDH20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDH20 Gene

ENSEMBL:
Gene Tree for CDH20 (if available)
TreeFam:
Gene Tree for CDH20 (if available)

Paralogs for CDH20 Gene

Paralogs for CDH20 Gene

Selected SIMAP similar genes for CDH20 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDH20: view

Variants for CDH20 Gene

Sequence variations from dbSNP and Humsavar for CDH20 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs123577 -- 61,545,761(+) CAAAG(A/G)GCAAA intron-variant
rs474087 -- 61,510,062(+) gagac(A/G)tgtca intron-variant
rs482937 -- 61,545,906(+) CCCCT(C/T)TTTTC intron-variant
rs484989 -- 61,520,661(+) cacca(A/G)tctaa intron-variant
rs486782 -- 61,546,355(+) AATGG(C/G)AAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH20 Gene

Variant ID Type Subtype PubMed ID
esv1603313 CNV Deletion 17803354
nsv524346 CNV Loss 19592680
esv271335 CNV Insertion 20981092
nsv909686 CNV Gain 21882294
esv2664717 CNV Deletion 23128226

Relevant External Links for CDH20 Gene

HapMap Linkage Disequilibrium report
CDH20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH20 Gene

Disorders for CDH20 Gene

Relevant External Links for CDH20

Genetic Association Database (GAD)
CDH20
Human Genome Epidemiology (HuGE) Navigator
CDH20
genes like me logo Genes that share disorders with CDH20: view

No data available for UniProtKB/Swiss-Prot for CDH20 Gene

Publications for CDH20 Gene

  1. Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7. (PMID: 10995570) Kools P. … van Roy F. (Genomics 2000) 2 3 4 23
  2. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough C.W. … Bowden D.W. (Hum. Genet. 2009) 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for CDH20 Gene

Sources for CDH20 Gene

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