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CDH2 Gene

protein-coding GIFtS: 66

GC18M023784

cadherin 2, type 1, N-cadherin (neuronal)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NCAD)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD325 ^¹, ²
CDHN ^¹, ², ³
CDw325 ^², ³
N-cadherin ^³
NCAD ^², ³, ⁵

Descriptions
CD325 antigen ^³
N-cadherin 1 ^²
Neural cadherin ^², ³
cadherin 2, N-cadherin (neuronal) ^²
cadherin 2, type 1 ^²
cadherin 2, type 1, N-cadherin (neuronal) ^²
calcium-dependent adhesion protein, neuronal ^²

External Ids
HGNC: 1759¹
Entrez Gene: 1000²
UniProtKB: P19022³
Ensembl: ENSG00000170558⁷

Search outside databases for aliases for CDH2 gene

Previous GC identifers: GC18M025465 GC18M025261 GC18M023782

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CDH2:

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium

dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a

transmembrane region and a highly conserved cytoplasmic tail. The protein functions during

gastrulation and is required for establishment of left-right asymmetry. At certain central nervous

system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene

product. [provided by RefSeq]

UniProtKB/Swiss-Prot: CADH2_HUMAN, P19022

Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with

themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the

sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism

Gene Wiki entry for CDH2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CDH2 gene

Entrez Gene cytogenetic band: 18q11.2 Ensembl cytogenetic band: 18q12.1 HGNC cytogenetic band: 18q12.1

CDH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M023784: (about GC identifiers)

Start:	23,784,933 bp from pter
End:	24,011,189 bp from pter
Size:	226,257 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000018.8 NT_010966.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CADH2_HUMAN, P19022 (See protein sequence)

Recommended Name: Cadherin-2 precursor

Size: 906 amino acids; 99809 Da

Subunit: Interacts with CDCP1

Subcellular location: Cell membrane; Single-pass type I membrane protein

Secondary accessions: Q14923 Q8N173

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001783.2

ENSEMBL proteins:

ENSP00000382312 ENSP00000269141

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for CDH2 (N-Cadherin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (pan Cadherin, N Cadherin)
	Human Recombinant Proteins from Abnova (CDH2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005912	adherens junction	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0030027	lamellipodium	IEA	--
GO:0045202	synapse	IEA	--

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Antibodies for CDH2:

	Invitrogen Antibodies for CDH2
	Millipore Mono- and Polyclonal Antibodies for the study of CDH2
	Sigma-Aldrich Antibody Arrays and Antibodies for CDH2
	R&D Systems Antibodies for CDH2 (N-Cadherin)
	Cell Signaling Technology (CST) Antibodies for CDH2 (N-Cadherin)
	Antibodies from Abcam (pan Cadherin, N Cadherin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CDH2)
	Novus Biologicals Antibodies for CDH2

Assays for CDH2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P19022

ProtoNet protein and cluster: P19022

3 Blocks protein families:

IPB000233 Cadherin cytoplasmic region

IPB002126 Cadherin

IPB009124 Desmocollin signature

UniProtKB/Swiss-Prot: CADH2_HUMAN, P19022

Similarity: Contains 5 cadherin domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDH2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CDH2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001792

Applied Biosystems Silencer® siRNAs for CDH2

Sigma-Aldrich siRNA and siRNA Panels for CDH2

Sigma-Aldrich shRNA Panels and shRNA for CDH2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001792
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001792
untagged cDNA clone in CMV expression vector: NM_001792

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001792

UniProtKB/Swiss-Prot: CADH2_HUMAN, P19022

Function: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with

themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the

sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism

Genatlas biochemistry entry for CDH2:

cadherin 2,N-cadherin,transmembrane glycoproteincomponent of adherens junction,containing a CCG

repeat in 5'utr,transmembrane glycoprotein component of adherens junction,expressed in

brain,putatively involved in synaptic adhesion,axon outgrowth and guidance,also expressed in

muscle

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cdh2):

	embryogenesis	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal
life span-post-weaning/aging	muscle	nervous system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for CDH2 (Your Favorite Gene powered by Ingenuity)

Wnt/&beta
Germ Cell-Sertoli Cell Junction Signaling

GeneDecks CDH2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CDH2

5/21 Interacting proteins for CDH2 (ENSP00000269141³ P19022^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 21 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN1	P18031²	STRING (score=.986) MINT-73487 MINT-73488 MINT-73489
CTNNB1	P35222²	STRING (score=.997) MINT-4085491
PTPN12	Q05209¹	EBI-2256711, EBI-2266035
PTPN22	Q9Y2R2¹	EBI-2256711, EBI-1211241
PTPN6	P29350¹	EBI-2256711, EBI-78260

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	2384753
GO:0007156	homophilic cell adhesion	IEA	--
GO:0007157	heterophilic cell adhesion	IEA	--
GO:0007416	synaptogenesis	IEA	--
GO:0016339	calcium-dependent cell-cell adhesion	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CDH2
10/22 Novoseek chemical compound relationships for CDH2 gene (see all 22 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	41.31	55	8707857 (8), 11106648 (4), 9786960 (2), 12377785 (2) (see all 27)
neurocan	35.40	2	10583905 (2)
matrigel	30.40	2	11696444 (1), 10934323 (1)
swainsonine	24.31	3	14561752 (1)
b 723	21.59	5	12883236 (3), 15188136 (2)
calcium	20.19	59	19162191 (5), 7962102 (3), 8090352 (3), 2303131 (2) (see all 25)
phosphatidylinositol	15.87	5	12095980 (3)
phosphotyrosine	14.61	1	11433418 (1)
glycogen	11.33	3	17389597 (2), 9314542 (1)
phosphoinositide	8.77	1	16962712 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CDH2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CDH2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001792

Sigma-Aldrich siRNA and siRNA Panels for CDH2

Sigma-Aldrich shRNA Panels and shRNA for CDH2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001792

REFSEQ mRNAs for CDH2 gene:

NM_001792.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001792

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001792
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001792
                                 untagged cDNA clone in CMV expression vector: NM_001792

Additional cDNA sequence:

AK129728.1 AK302831.1 BC021695.1 BC036470.1 BX648579.1 M34064.1 S42303.1 X54315.1

X57548.1

5 DOTS entries:

DT.414612 DT.92433029 DT.95273907 DT.65288085 DT.121096711

24/137 AceView cDNA sequences (see all 137 ):

C04763 CK724900 AL041311 AI064969 AA653561 BQ772138 AV705261 BM693820

BE464612 AI611780 BM966740 BM670881 AU132015 AA410423 AI127140 W49619

CK725209 BM893528 BG197310 BX955043 AL046467 AI675151 AU120201 AA661623

highest scoring ESTs for CDH2:

AL046467 BC036470 BI460696 BI461974 BI547033 BI549642 M34064 S42303 X54315 AA069613

Unigene Cluster for CDH2:

Cadherin 2, type 1, N-cadherin (neuronal)

Hs.464829 [show with all ESTs]

Unigene Representative Sequence: NM_001792

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDH2 (see all 7 )

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20
SP1:					-				-		-		-		-
SP2:													-		-
SP3:															-
SP4:
SP5:									-		-		-		-

About this scheme

ECgene alternative splicing isoforms for CDH2

2 Ensembl transcripts including schematic representations:

ENST00000399380 ENST00000269141

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CDH2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CDH2

¹ / ² / ³

6 probe-sets matching CDH2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2053_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.33	M34064	0.80	1.00	0.91	1
2054_g_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.70	M34064	0.80	1.00	0.91	1
203440_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M34064	0.80	1.00	0.91	1
203441_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_001792	0.60	1.00	0.82	1
203440_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203441_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks CDH2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTCTCATCCC

SOURCE GeneReport for Unigene cluster: Hs.464829
Expression variation in blood from EXPOLDB for CDH2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CDH2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CDH2¹	--	cadherin 2, type 1, N-cadherin (neuronal)	92.97(n) 98.34(a)	480169 XM_537293.2 XP_537293.2
chimpanzee (Pan troglodytes)	CDH2¹	--	cadherin 2, type 1, N-cadherin (neuronal)	99.59(n) 99.67(a)	468509 XM_523898.2 XP_523898.2
cow (Bos taurus)	CDH2¹	--	cadherin 2, type 1, N-cadherin (neuronal)	91.39(n) 97.13(a)	281062 XM_001250829.1 XP_001250830.1
rat (Rattus norvegicus)	Cdh2¹	--	cadherin 2	87.23(n) 96.58(a)	83501 NM_031333.1 NP_112623.1
mouse (Mus musculus)	Cdh2^{1, 5}	18 (6.00 cM)⁵	cadherin 2^{1, 5}	88.23(n)¹ 96.36(a)¹	12558¹ NM_007664.3¹ NP_031690.2¹ AB008811⁵ AK031210⁵ (see all 13)

About this table Species with no ortholog for CDH2

ENSEMBL Gene Tree for CDH2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CDH2 gene

CDH4² CDH13² CDH15²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1793 NCBI SNPs in CDH2 are shown (see all 1793 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1004)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4800836^1,2	A,C,F,H	23785066(+)	`TTTTTA/TAAAAA`	1	--	ut3¹		4	EU EA WA	416
	rs11564422^1,2	C,F,H	23786078(+)	`AAATTG/ATTTGT`	1	--	ut3¹		17	NA EU EA WA NS	1614
	rs3760604^1,2	C,F,H	24012695(-)	`TGGTAG/AGAGAG`	1	--	ng3¹		5	EU EA WA	592
	rs1789467^1,2	C,F,H	24013111(-)	`AATAAA/TGTTAA`	1	--	ng3¹ tfbs³		2	EU EA	278
	rs2289664^1,2	C,F,H	23786302(+)	`GGTCAT/CTGTCA`	1	S/N	mis¹		10	EA EU WA	2500
	rs11083255^1,2	C,F,H	24013162(+)	`ACCTTT/CAAAAA`	1	--	ng3¹		9	EU EA WA	988
	rs1639387^1,2	C,F,H	24012895(+)	`TGGAAT/CGGAGC`	1	--	ng3¹		6	MN EU EA WA	776
	rs1041970^1,2	C,F,H	23843794(-)	`GTACAG/CTGTAA`	1	T/S	mis¹ ese³		5	EU EA WA	566
	rs3760603^1,2	C,F,H	24012863(-)	`TGTAAA/GGTCTC`	1	--	ng3¹		6	EA EU WA	2064
	rs17445840^1,2	C,F,H	23847692(+)	`TACTGC/TCACTT`	1	A/T	mis¹		9	EU EA WA NS	874

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HapMap Linkage Disequilibrium images for CDH2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 114020

10/75 Novoseek disease relationships for CDH2 gene (see all 75 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	51.13	49	19360298 (6), 12508543 (5), 12569568 (2), 15217949 (2) (see all 25)
epithelial tumor	51.08	4	9191009 (1), 15262114 (1), 16258702 (1), 16596172 (1)
malignant mesothelioma	49.50	5	10849094 (2), 14595746 (1), 15717748 (1), 12194995 (1)
tumors	48.24	159	16675571 (7), 9191009 (5), 18622386 (4), 17564818 (4) (see all 77)
melanoma	44.58	88	17668445 (6), 16371504 (5), 16784991 (5), 15316281 (4) (see all 34)
ovarian carcinoma	43.32	6	11684957 (1), 17266044 (1), 16788982 (1), 18930836 (1) (see all 5)
mesothelioma	42.36	20	14506634 (4), 8522310 (2), 15717748 (2), 9190996 (2) (see all 9)
pleural malignant mesothelioma	39.42	10	10227598 (4), 8522310 (3), 9190996 (1)
carcinoma	34.81	30	14645693 (3), 16258702 (3), 11684957 (2), 9269828 (1) (see all 22)
carcinoma neuroendocrine	30.12	2	18269586 (2)

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Human Genome Epidemiology Navigator: CDH2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/599 PubMed articles for CDH2 gene (see all 599 ):

N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene. (PubMed id 2384753)^{1, 2, 3, 4} Walsh F.S....Goodfellow P.N. (1990)
Human N-cadherin: nucleotide and deduced amino acid sequence. (PubMed id 2216790)^{2, 3, 4} Reid R.A. and Hemperly J.J. (1990)
Adhesion signaling by a novel mitotic substrate of src kinases. (PubMed id 16007225)^{3, 4} Bhatt A.S.... Moasser M.M. (2005)
Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC). (PubMed id 16212419)^{3, 4} Amanchy R.... Pandey A. (2005)
Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene. (PubMed id 7731968)^{2, 3} Selig S....Kunkel L.M. (1995)
Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2. (PubMed id 7959764)^{3, 4} Wallis J.A.... Walsh F.S. (1994)
Extrajunctional distribution of N-cadherin in cultured human endothelial cells. (PubMed id 1500442)^{3, 4} Salomon D.... Geiger B. (1992)
Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization. (PubMed id 9508779)^{1, 3} Navarro P....Dejana E. (1998)
N-cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas. (PubMed id 18622386)^{1, 3} Mosnier J.F....Laboisse C.L. (2009)
N-cadherin levels in endothelial cells are regulated by monolayer maturity and p120 availability. (PubMed id 18979298)^{1, 3} Ferreri D.M....Vincent P.A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1000	HGNC: 1759	AceView: CDH2	Ensembl:ENSG00000170558	euGenes: HUgn1000
ECgene: CDH2	H-InvDB: CDH2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CDH2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CDH2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CDH2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CDH2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CDH2		Antibodies for CDH2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CDH2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CDH2)
	Antibodies (CDH2)
	Chimera RNAi (CDH2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CDH2 (N-Cadherin)

	Recombinant Proteins (pan Cadherin, N Cadherin)
	Antibodies (pan Cadherin, N Cadherin)

Search OriGene for CDH2

Search Tocris compounds for CDH2

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Antibodies for CDH2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CDH2 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CDH2

Summaries
for CDH2

Genomic Location
for CDH2

Proteins
for CDH2

Protein Domains/
Families
for CDH2

Gene Function
for CDH2

Pathways & Interactions
for CDH2

Drugs & Compounds
for CDH2

Transcripts
for CDH2

Expression
for CDH2

Orthologs
for CDH2

Paralogs
for CDH2

SNPs/Variants
for CDH2

Disorders & Mutations
for CDH2

Medical News
for CDH2

Publications
for CDH2

Search for CDH2

Genome Databases showing CDH2

Other Databases showing CDH2

Specialized Databases showing CDH2

Licensable Technologies
for CDH2

Services
for CDH2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CDH2 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CDH2

Summariesfor CDH2

Genomic Locationfor CDH2

Proteinsfor CDH2

Protein Domains/Familiesfor CDH2

Gene Functionfor CDH2

Pathways & Interactionsfor CDH2

Drugs & Compoundsfor CDH2

Transcriptsfor CDH2

Expression for CDH2

Orthologsfor CDH2

Paralogsfor CDH2

SNPs/Variantsfor CDH2

Disorders & Mutationsfor CDH2

Medical Newsfor CDH2

Publicationsfor CDH2

Search for CDH2

Genome Databases showing CDH2

Other Databases showing CDH2

Specialized Databases showing CDH2

Licensable Technologiesfor CDH2

Servicesfor CDH2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CDH2

Summaries
for CDH2

Genomic Location
for CDH2

Proteins
for CDH2

Protein Domains/
Families
for CDH2

Gene Function
for CDH2

Pathways & Interactions
for CDH2

Drugs & Compounds
for CDH2

Transcripts
for CDH2

Expression
for CDH2

Orthologs
for CDH2

Paralogs
for CDH2

SNPs/Variants
for CDH2

Disorders & Mutations
for CDH2

Medical News
for CDH2

Publications
for CDH2

Licensable Technologies
for CDH2

Services
for CDH2