Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDH2 Gene

Aliases for CDH2 Gene

  • Cadherin 2, Type 1, N-Cadherin (Neuronal) 2 3
  • Neural Cadherin 3 4
  • N-Cadherin 2 4
  • CDw325 3 4
  • NCAD 3 4
  • CDHN 3 4
  • Calcium-Dependent Adhesion Protein, Neuronal 3
  • Cadherin 2, N-Cadherin (Neuronal) 3
  • Neural-Cadherin 3
  • CD325 Antigen 4
  • N-Cadherin 1 3
  • N-Cadherin) 6
  • Cadherin-2 3
  • CD325 3

External Ids for CDH2 Gene

Previous Symbols for CDH2 Gene

  • NCAD

Summaries for CDH2 Gene

Entrez Gene Summary for CDH2 Gene

  • This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH2 Gene

CDH2 (Cadherin 2, Type 1, N-Cadherin (Neuronal)) is a Protein Coding gene. Diseases associated with CDH2 include pseudomyxoma peritonei and hypoplastic left heart syndrome. Among its related pathways are L1CAM interactions and ERK Signaling. GO annotations related to this gene include calcium ion binding and protein phosphatase binding. An important paralog of this gene is CDH13.

UniProtKB/Swiss-Prot for CDH2 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

Gene Wiki entry for CDH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH2 Gene

Genomics for CDH2 Gene

Genomic Location for CDH2 Gene

Start:
27,950,966 bp from pter
End:
28,177,481 bp from pter
Size:
226,516 bases
Orientation:
Minus strand

Genomic View for CDH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH2 Gene

Regulatory Elements for CDH2 Gene

Proteins for CDH2 Gene

  • Protein details for CDH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19022-CADH2_HUMAN
    Recommended name:
    Cadherin-2
    Protein Accession:
    P19022
    Secondary Accessions:
    • A8MWK3
    • B0YIY6
    • Q14923
    • Q8N173

    Protein attributes for CDH2 Gene

    Size:
    906 amino acids
    Molecular mass:
    99809 Da
    Quaternary structure:
    • Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway (By similarity).

    Alternative splice isoforms for CDH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH2 Gene

Proteomics data for CDH2 Gene at MOPED

Post-translational modifications for CDH2 Gene

  • Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys756
  • Glycosylation at Asn190, Asn273, Asn325, Asn402, Asn572, Asn651, and Asn692

Other Protein References for CDH2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDH2 Gene

Domains for CDH2 Gene

Gene Families for CDH2 Gene

HGNC:
  • CD :CD molecules
  • MCDH :Cadherins / Major cadherins

UniProtKB/Swiss-Prot:

CADH2_HUMAN
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 (By similarity).:
    • P19022
  • Contains 5 cadherin domains.:
    • P19022
genes like me logo Genes that share domains with CDH2: view

Function for CDH2 Gene

Molecular function for CDH2 Gene

GENATLAS Biochemistry: cadherin 2,N-cadherin,transmembrane glycoproteincomponent of adherens junction,containing a CCG repeat in 5utr,transmembrane glycoprotein component of adherens junction,expressed in brain,putatively involved in synaptic adhesion,axon outgrowth and guidance,also expressed in muscle
UniProtKB/Swiss-Prot Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

Gene Ontology (GO) - Molecular Function for CDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 17057644
GO:0008013 beta-catenin binding TAS 16344550
GO:0019899 enzyme binding --
GO:0019903 protein phosphatase binding IEA --
genes like me logo Genes that share ontologies with CDH2: view
genes like me logo Genes that share phenotypes with CDH2: view

Animal Models for CDH2 Gene

MGI Knock Outs for CDH2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CDH2 Gene

Localization for CDH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH2 Gene COMPARTMENTS Subcellular localization image for CDH2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
extracellular 2
nucleus 2
peroxisome 2
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for CDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IDA 7650039
GO:0005912 adherens junction --
GO:0005913 cell-cell adherens junction IDA 19101069
GO:0005916 fascia adherens IEA --
genes like me logo Genes that share ontologies with CDH2: view

Pathways for CDH2 Gene

genes like me logo Genes that share pathways with CDH2: view

Gene Ontology (GO) - Biological Process for CDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 2384753
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
GO:0010001 glial cell differentiation ISS --
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
genes like me logo Genes that share ontologies with CDH2: view

Compounds for CDH2 Gene

(1) HMDB Compounds for CDH2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(40) Novoseek inferred chemical compound relationships for CDH2 Gene

Compound -log(P) Hits PubMed IDs
matrigel 42.5 3
tyrosine 40.4 43
paraffin 34.4 11
neurocan 33.1 2
swainsonine 22.1 1
genes like me logo Genes that share compounds with CDH2: view

Transcripts for CDH2 Gene

Unigene Clusters for CDH2 Gene

Cadherin 2, type 1, N-cadherin (neuronal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - -
SP2: - -
SP3: -
SP4:
SP5: - - - -
SP6: - - - - -
SP7: - - -

Relevant External Links for CDH2 Gene

GeneLoc Exon Structure for
CDH2
ECgene alternative splicing isoforms for
CDH2

Expression for CDH2 Gene

mRNA expression in normal human tissues for CDH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH2 Gene

This gene is overexpressed in Heart - Left Ventricle (11.4), Heart - Atrial Appendage (5.3), and Adrenal Gland (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDH2 Gene

SOURCE GeneReport for Unigene cluster for CDH2 Gene Hs.464829

genes like me logo Genes that share expressions with CDH2: view

Orthologs for CDH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH2 36
  • 99.63 (n)
  • 99.67 (a)
CDH2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDH2 36
  • 91.39 (n)
  • 97.13 (a)
CDH2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH2 36
  • 93.05 (n)
  • 98.34 (a)
NCAD 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh2 36
  • 88.34 (n)
  • 96.8 (a)
Cdh2 16
Cdh2 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDH2 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH2 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh2 36
  • 87.2 (n)
  • 96.58 (a)
chicken
(Gallus gallus)
Aves CDH2 36
  • 79.65 (n)
  • 85.98 (a)
CDH2 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH2 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1873 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh2 36
  • 74.12 (n)
  • 80.93 (a)
Str.2251 36
zebrafish
(Danio rerio)
Actinopterygii cdh2 36
  • 67.89 (n)
  • 72.97 (a)
cdh2 37
  • 72 (a)
OneToOne
Species with no ortholog for CDH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH2 Gene

ENSEMBL:
Gene Tree for CDH2 (if available)
TreeFam:
Gene Tree for CDH2 (if available)

Paralogs for CDH2 Gene

Paralogs for CDH2 Gene

genes like me logo Genes that share paralogs with CDH2: view

Variants for CDH2 Gene

Sequence variations from dbSNP and Humsavar for CDH2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs472901 -- 28,059,963(-) aatta(C/G)agaat intron-variant
rs474904 -- 28,042,330(-) TAACG(A/C/T)AATTA intron-variant
rs481860 -- 27,999,728(-) ATATA(C/T)ACAAA intron-variant
rs482950 -- 28,108,214(-) CAAAG(A/C)AAATG intron-variant
rs484755 -- 28,031,887(-) GATTT(A/G)ACTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH2 Gene

Variant ID Type Subtype PubMed ID
nsv833605 CNV Gain 17160897
nsv9622 CNV Loss 18304495

Relevant External Links for CDH2 Gene

HapMap Linkage Disequilibrium report
CDH2
Human Gene Mutation Database (HGMD)
CDH2

Disorders for CDH2 Gene

(1) University of Copenhagen DISEASES for CDH2 Gene

(76) Novoseek inferred disease relationships for CDH2 Gene

Disease -log(P) Hits PubMed IDs
metastasis 54.1 52
epithelial tumor 51.9 4
tumors 50.9 148
malignant mesothelioma 47.3 5
melanoma 44 71

Relevant External Links for CDH2

Genetic Association Database (GAD)
CDH2
Human Genome Epidemiology (HuGE) Navigator
CDH2
genes like me logo Genes that share disorders with CDH2: view

No data available for UniProtKB/Swiss-Prot for CDH2 Gene

Publications for CDH2 Gene

  1. N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene. (PMID: 2384753) Walsh F.S. … Goodfellow P.N. (J. Neurochem. 1990) 2 3 4 23
  2. Human N-cadherin: nucleotide and deduced amino acid sequence. (PMID: 2216790) Reid R.A. … Hemperly J.J. (Nucleic Acids Res. 1990) 2 3 4
  3. Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene. (PMID: 7731968) Selig S. … Kunkel L.M. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3
  4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for CDH2 Gene

  • Addgene plasmids for CDH2

Sources for CDH2 Gene

Back to Top

Content