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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDH2 Gene

protein-coding GIFtS: 70
GCID: GC18M025530

cadherin 2, type 1, N-cadherin (neuronal)

(Previous symbol: NCAD)

Explore 92 diseases affiliated with
CDH2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cadherin 2, Type 1, N-Cadherin (Neuronal)¹ ²		Cadherin-2¹
NCAD¹ ² ³ ⁵		Calcium-Dependent Adhesion Protein, Neuronal²
CDHN¹ ² ³		N-Cadherin 1²
CD325¹ ²		Neural-Cadherin¹
Neural Cadherin² ³		N-Cadherin¹
CDw325² ³		CD325 Antigen³
Cadherin 2, N-Cadherin (Neuronal)²

External Ids:	HGNC: 1759¹	Entrez Gene: 1000²	Ensembl: ENSG00000170558⁷	OMIM: 114020⁵	UniProtKB: P19022³

Export aliases for CDH2 gene to outside databases

Previous GC identifers: GC18M025465 GC18M025261 GC18M023782 GC18M023784 GC18M022383

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDH2:

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell

adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved

cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.

At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this

gene product. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CADH2_HUMAN, P19022

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a

homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2

may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By

similarity)

Gene Wiki entry for CDH2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010966.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDH2 gene promoter:
Sp1 SRF (504 AA) Nkx2-2 Nkx2-5 HNF-3beta IRF-2 FOXO4 LyF-1 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDH2 promoter sequence

Search SABiosciences Chromatin IP Primers for CDH2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDH2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11.2 Ensembl cytogenetic band: 18q12.1 HGNC cytogenetic band: 18q12.1

CDH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH2 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M025530: view genomic region (about GC identifiers)

Start:	25,530,930 bp from pter	End:	25,757,445 bp from pter
Size:	226,516 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CADH2_HUMAN, P19022 (See protein sequence)

Recommended Name: Cadherin-2 precursor

Size: 906 amino acids; 99809 Da

Subunit: Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and

CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to

internalization through TAOK2/p38 MAPK pathway (By similarity)

Subcellular location: Cell membrane; Single-pass type I membrane protein

Secondary accessions: B0YIY6 Q14923 Q8N173

Explore the universe of human proteins at neXtProt for CDH2: NX_P19022

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P19022

CDH2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001783.2

ENSEMBL proteins:

ENSP00000269141 ENSP00000382312 ENSP00000411360 ENSP00000412120 ENSP00000414269

Reactome Protein details: P19022
Human Recombinant Protein Products for CDH2:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals CDH2 Proteins Novus Biologicals CDH2 Lysate
	Sino Biological Recombinant Protein for CDH2
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDH2

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005911	cell-cell junction	IDA	7650039
GO:0005912	adherens junction	--	--
GO:0005913	cell-cell adherens junction	IDA	19101069

CDH2 for ontologies About GeneDecksing

CDH2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CDH2
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	Cell Signaling Technology (CST) Antibodies for CDH2
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	GenScript Custom Superior Antibodies Services for CDH2
	Novus Biologicals CDH2 Antibodies
	Abcam antibodies for CDH2
	Uscn Antibodies for CDH2
	ThermoFisher Antibody for CDH2

Assay Products for CDH2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for CDH2 (N-Cadherin)
	GenScript Custom Assay Services for CDH2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDH2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDH2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR000233 Cadherin_cytoplasmic-dom

IPR009124 Desmocollin

IPR015919 Cadherin-like

IPR014868 Cadherin_pro_dom

IPR020894 Cadherin_CS

Graphical View of Domain Structure for InterPro Entry P19022

ProtoNet protein and cluster: P19022

3 Blocks protein families:

IPB000233 Cadherin cytoplasmic region

IPB002126 Cadherin

IPB009124 Desmocollin signature

UniProtKB/Swiss-Prot: CADH2_HUMAN, P19022

Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections,

imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the

order of site 3, then site 2 and site 1 (By similarity)

Similarity: Contains 5 cadherin domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CADH2_HUMAN, P19022

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a

homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2

may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By

cadherin 2,N-cadherin,transmembrane glycoproteincomponent of adherens junction,containing a CCG repeat in

5'utr,transmembrane glycoprotein component of adherens junction,expressed in brain,putatively involved in synaptic

adhesion,axon outgrowth and guidance,also expressed in muscle

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	--	--
GO:0005543	phospholipid binding	--	--
GO:0008013	beta-catenin binding	TAS	16344550
GO:0019901	protein kinase binding	--	--

CDH2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CDH2:

Decreased focal adhesion (FA)

Increased G2M DNA content

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cdh2):

cardiovascular system	cellular	embryogenesis	growth/size	homeostasis/metabolism
mortality/aging	muscle	nervous system

CDH2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cdh2^tm1Hyn for CDH2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDH2

miRNA Products:		miRTarBase miRNAs that target CDH2: hsa-mir-204 (MIRT005821), hsa-mir-194 (MIRT005889)

		OriGene 3'-UTR Clone: CDH2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDH2
		8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate CDH2 (see all 95):
		hsa-miR-411* hsa-miR-520f hsa-miR-3607-3p hsa-miR-3938 hsa-miR-642a hsa-miR-411 hsa-miR-605 hsa-miR-3074-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CDH2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDH2 (see all 7) OriGene shRNA RFP: CDH2 OriGene siRNA: CDH2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDH2
		Sirion Biotech Custom design and validation of potent shRNA sequences against CDH2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CDH2
			Sirion Biotech Customized adenovirus for overexpression of CDH2 Sirion Biotech Customized adenovirus for potent knockdown of CDH2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDH2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDH2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CDH2 (NM_001792)
		Sino Biological Human cDNA Clone for CDH2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDH2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CDH2
		LifeMap BioReagents: cell lines associated with CDH2: PureStem 4D20.8, NCr-fac Progenitor, PureStem E15, Meso-prx/latp Progenitor, PureStem ES-210, Ecto-ntu Progenitor
		Sirion Biotech Customized stable knockdown cell line services for CDH2 Sirion Biotech Customized inducible knockdown cell line services for CDH2 Sirion Biotech Customized stable overexpressing cell line services for CDH2 Sirion Biotech Customized inducible overexpressing cell line services for CDH2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of p38 alpha/beta MAPK

	Activation of p38 alpha/beta MAPK	1.00			CDO in myogenesis	0.55
	Nuclear translocation of p38 MAPK	0.94			Myogenesis	0.55

Cell-cell junction organization

	Cell-cell junction organization	1.00			Adherens junctions interactions	0.51
	Cell junction organization	0.69			Cell-Cell communication	0.45

Cell adhesion Endothelial cell contacts by junctional mechanisms

Cell adhesion Endothelial cell contacts by junctional mechanisms

1.00

Cell adhesion_Endothelial cell contacts by junctional mechanisms

0.97

Rho Family GTPases

Rho Family GTPases

1.00

ILK Signaling

0.45

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

1.00

Arrhythmogenic right ventricular cardiomyopathy

0.99

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CDH2

	Cell adhesion Endothelial cell contacts by junctional mechanisms
	Cell adhesion Cadherin-mediated cell adhesion
	Cell adhesion Endothelial cell contacts by non-junctional mechanisms

5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDH2 (see all 9)

	S-1P Stimulated Signaling
	G12-G13 in Cellular Signaling
	Epithelial Adherens Junctions
	ILK Signaling
	GSK3 Signaling

1 Cell Signaling Technology (CST) Pathway for CDH2

Adhesion

3 GeneGo (Thomson Reuters) Pathways for CDH2

	Cell adhesion Endothelial cell contacts by non-junctional mechanisms
	Cell adhesion Endothelial cell contacts by junctional mechanisms
	Cell adhesion Cadherin-mediated cell adhesion

5 BioSystems Pathways for CDH2

	Neural Crest Differentiation
	Arrhythmogenic right ventricular cardiomyopathy
	FGF signaling pathway
	Signaling events mediated by PTP1B
	N-cadherin signaling events

5/9 Reactome Pathways for CDH2 (see all 9)

	Developmental Biology
	Myogenesis
	Nuclear translocation of p38 MAPK
	Activation of p38 alpha/beta MAPK
	Adherens junctions interactions

2 Kegg Pathways (Kegg details for CDH2):

	Cell adhesion molecules (CAMs)
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)

CDH2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDH2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/92 Interacting proteins for CDH2 (P19022^{2, 3} ENSP00000269141⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 92)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN1	P18031²^,³, ENSP00000360683⁴	MINT-73487 MINT-73488 MINT-73489 I2D: score=3 STRING: ENSP00000360683
CTNNB1	P35222²^,³, ENSP00000344456⁴	MINT-4085491 I2D: score=8 STRING: ENSP00000344456
CTNND1	O60716³, ENSP00000382004⁴	I2D: score=4 STRING: ENSP00000382004
ARVCF	O00192³, ENSP00000263207⁴	I2D: score=3 STRING: ENSP00000263207
CDH4	P55283³, ENSP00000353656⁴	I2D: score=3 STRING: ENSP00000353656

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	2384753
GO:0007156	homophilic cell adhesion	IEA	--
GO:0007157	heterophilic cell-cell adhesion	IEA	--
GO:0007416	synapse assembly	--	--
GO:0016337	cell-cell adhesion	--	--

CDH2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDH2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDH2

1 HMDB Compound for CDH2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

10/40 Novoseek chemical compound relationships for CDH2 gene (see all 40) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel	42.5	4	11696444 (1), 10934323 (1), 19070520 (1)
tyrosine	40.4	58	8707857 (8), 11106648 (4), 9786960 (2), 12377785 (2) (see all 30)
paraffin	34.4	11	9191009 (1), 12657131 (1), 12800081 (1), 12204061 (1) (see all 11)
neurocan	33.1	2	10583905 (2)
swainsonine	22.1	3	14561752 (1)
glycogen	20.2	3	17389597 (2), 9314542 (1)
b 723	20	5	12883236 (3), 15188136 (2)
cytochalasin d	19.2	1	12095980 (1)
calcium	17.1	59	19162191 (5), 7962102 (3), 8090352 (3), 2303131 (2) (see all 25)
phosphatidylinositol	16.2	6	12095980 (3), 19546217 (1)

Search CenterWatch for drugs/clinical trials and news about CDH2 / CADH2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDH2 gene:

NM_001792.3

Unigene Cluster for CDH2:

Cadherin 2, type 1, N-cadherin (neuronal)

Hs.464829 [show with all ESTs]

Unigene Representative Sequence: NM_001792

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000269141(uc010xbn.1 uc002kwg.2) ENST00000399380 ENST00000418492

ENST00000430882 ENST00000413878

miRNA Products:		OriGene 3'-UTR Clone: CDH2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDH2
		8/95 QIAGEN miScript miRNA Assays for microRNAs that regulate CDH2 (see all 95):
		hsa-miR-411* hsa-miR-520f hsa-miR-3607-3p hsa-miR-3938 hsa-miR-642a hsa-miR-411 hsa-miR-605 hsa-miR-3074-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CDH2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDH2 (see all 7) OriGene shRNA RFP: CDH2 OriGene siRNA: CDH2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CDH2

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		GenScript: all cDNA clones in your preferred vector: CDH2 (NM_001792)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDH2
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDH2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDH2

Additional cDNA sequence:

AK129728.1 AK302831.1 BC021695.1 BC036470.1 BX648579.1 M34064.1 S42303.1 X54315.1

X57548.1

5 DOTS entries:

DT.414612 DT.92433029 DT.95273907 DT.121096711 DT.65288085

24/137 AceView cDNA sequences (see all 137):

AI064969 AV705261 CK724900 BE464612 BM693820 BM893528 W49619 BM966740

BX955043 AU132015 BG197310 AL041311 BQ772138 C04763 AA653561 BM670881

AI127140 AI611780 CK725209 AA410423 BG779350 AI161223 AW241578 AU149944

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CDH2 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20
SP1:					-				-		-		-		-
SP2:													-		-
SP3:															-
SP4:
SP5:									-		-		-		-

ECgene alternative splicing isoforms for CDH2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTATATCTT

About this image

CDH2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/54 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 54)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pericytes

Autopod Epiphyseal End

Prechondrocytes

Bone, Cartilage

Bone

Stylopod Epiphyseal End

Prechondrocytes

Bone, Cartilage

Bone

Zeugopod Epiphyseal End

Prechondrocytes

Bone, Cartilage

Bone

Autopod Perichondrium

Endochondral Preosteoblasts

Bone

Cervical Vertebrae

Endochondral Preosteoblasts

Bone

Lumbar Vertebrae

Endochondral Preosteoblasts

Bone

Sacral Vertebrae

Endochondral Preosteoblasts

Bone

Stylopod Perichondrium

Endochondral Preosteoblasts

Bone

Thoracic Rib

Endochondral Preosteoblasts

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/16 LifeMap Cells (see all 16)

Name

Category

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

Mesendoderm-like cells (A scalable, suspensi...)

Primitive gut tube-like cells (A scalable, suspensi...)

See CDH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDH2

SOURCE GeneReport for Unigene cluster: Hs.464829

SABiosciences Expression via Pathway-Focused PCR Arrays including CDH2 (see all 7):

Extracellular Matrix & Adhesion Molecules in human mouse rat

Adherens Junctions in human mouse rat

Cancer PathwayFinder in human mouse rat

Cell Junction PathwayFinder in human mouse rat

Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CDH2 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CDH2¹	cadherin 2, type 1, N-cadherin (neuronal)	79.73(n) 86.09(a)		414745 NM_001001615.1 NP_001001615.1
lizard (Anolis carolinensis)	Reptilia	CDH2⁶	--	85(a)	1 ↔ 1	4(35949027-36001729)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1873²	X.laevis mRNA for N-cadherin (clone 1)	78.56(n)		X57675.1
zebrafish (Danio rerio)	Actinopterygii	cdh2²	cadherin 2, neuronal	77.71(n)		30291 AF430842.1

ENSEMBL Gene Tree for CDH2 (if available)
TreeFam Gene Tree for CDH2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDH2 gene

CDH4² CDH18² DSG4² CDH3² CDH10² CDH11² CDH1² CDH6²

DSC2² CDH8² CDH20² CDH22² DSC1² CDH19² DSG1² CDH7²

DSG2² CDH9² CDH12² CDH26² DSC3² CDH24² CDH15² CDH5²

DSG3²

18/27 SIMAP similar genes for CDH2 using alignment to 5 protein entries: CADH2_HUMAN (see all proteins) (see all similar genes):

DKFZp434K1130 CDH4 CDH3 CDH1 CDH15 CDH13

CDH10 CDH7 CDH8 CDH9 CDH11 CDH18

CDH20 CDH6 CDH26 CDH24 CDH12 Nbla04261

CDH2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7240525^1,2	C,F,H	--	22382625(+)	`ATGGCT/GTCAAT`	1	--	ds500¹		9		NS EA NA WA	924
rs17445517^1,2	C,H	--	22382774(+)	`CAAATT/AAAAAC`	1	--	ds500¹		5		NS EA NA	420
rs17467885^1,2	C,H	--	22383254(+)	`ACCCCT/CTTCTT`	1	--	ut3¹ ese³ trp³		5		NS EA NA	418
rs17467892^1,2	C,H	--	22383257(+)	`CCTTTC/TTTTCC`	1	--	ut3¹ trp³		5		NS EA NA	420
rs150789932^1,2	C	--	22383526(+)	`CTCCAC/TAGACT`	1	--	ut3¹		0	--	--	--	--
rs17445531^1,2	C,H	--	22383653(+)	`AAATTC/TAATTT`	1	--	ut3¹		4		NS EA	418
rs139160577^1,2	C	--	22383671(+)	`AATTGA/GTGATA`	1	--	ut3¹		0	--	--	--	--
rs181063575^1,2	C	--	22383838(+)	`TTGTTC/TAATTT`	1	--	ut3¹		0	--	--	--	--
rs17493056^1,2	C,H	--	22383946(+)	`TTATCG/ATTTCA`	1	--	ut3¹ ese³		4		NS EA	418
rs2289665^1,2	C,F,H	--	22384547(+)	`TTCACG/AGGATC`	1	--	int¹		10		NS EA NA	1032

HapMap Linkage Disequilibrium report for CDH2 (25530930 - 25757445 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CDH2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDH2 for disorders           About GeneDecksing

OMIM gene information: 114020    OMIM disorders: --

20/92 diseases for CDH2 (see all 92):    About MalaCards

atypical teratoid rhabdoid tumor spinal muscular atrophy cleft lip/palate familial adenomatous polyposis

pseudomyxoma peritonei neural tube defect adenomatous polyposis coli neuronitis

malignant mesothelioma cleft lip multiple endocrine neoplasia inflammatory bowel disease

anaplastic astrocytoma rhabdoid tumors muscular atrophy squamous cell carcinoma

carcinoma cutaneous malignant melanoma spindle cell carcinoma atrial fibrillation

1 disease from the University of Copenhagen DISEASES database for CDH2:

Cancer

10/76 Novoseek disease relationships for CDH2 gene (see all 76) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	54.1	64	19360298 (6), 12508543 (5), 20233707 (5), 12569568 (2) (see all 32)
epithelial tumor	51.9	4	9191009 (1), 15262114 (1), 16258702 (1), 16596172 (1)
tumors	50.9	181	16675571 (7), 20233707 (7), 9191009 (5), 18622386 (4) (see all 90)
malignant mesothelioma	47.3	5	10849094 (2), 14595746 (1), 15717748 (1), 12194995 (1)
melanoma	44	88	17668445 (6), 16371504 (5), 16784991 (5), 15316281 (4) (see all 34)
ovarian carcinoma	41.1	6	11684957 (1), 17266044 (1), 16788982 (1), 18930836 (1) (see all 5)
mesothelioma	39.9	20	14506634 (4), 8522310 (2), 15717748 (2), 9190996 (2) (see all 9)
cancer	38.6	53	17371194 (3), 17414625 (2), 12526217 (2), 15717748 (2) (see all 31)
carcinoma	37.7	39	14645693 (3), 16258702 (3), 20388391 (3), 11684957 (2) (see all 27)
pleural malignant mesothelioma	36.6	10	10227598 (4), 8522310 (3), 9190996 (1)

Human Genome Epidemiology (HuGE) Navigator: CDH2 (5 documents)

Export disorders for CDH2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDH2 gene, integrated from 9 sources (see all 734):
(articles sorted by number of sources associating them with CDH2)

Utopia: connect your pdf to the dynamic
world of online information

N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene. (PubMed id 2384753)^{1, 2, 3, 9} Walsh F.S....Goodfellow P.N. (1990)
Human N-cadherin: nucleotide and deduced amino acid sequence. (PubMed id 2216790)^{1, 2, 3} Reid R.A. and Hemperly J.J. (1990)
Adhesion signaling by a novel mitotic substrate of src kinases. (PubMed id 16007225)^{1, 2} Bhatt A.S.... Moasser M.M. (2005)
Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene. (PubMed id 7731968)^{1, 3} Selig S....Kunkel L.M. (1995)
Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2. (PubMed id 7959764)^{1, 2} Wallis J.A.... Walsh F.S. (1994)
Extrajunctional distribution of N-cadherin in cultured human endothelial cells. (PubMed id 1500442)^{1, 2} Salomon D.... Geiger B. (1992)
Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization. (PubMed id 9508779)^{1, 9} Navarro P....Dejana E. (1998)
N-cadherin increases after androgen deprivation and i s associated with metastasis in prostate cancer. (PubMed id 20233707)^{1, 9} Jennbacken K....WelAcn K. (2010)
Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines. (PubMed id 19070520)^{1, 9} Wallerand H....Reiter R.R. (2010)
N-cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas. (PubMed id 18622386)^{1, 9} Mosnier J.F....Laboisse C.L. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1000	HGNC: 1759	AceView: CDH2	Ensembl:ENSG00000170558	euGenes: HUgn1000
ECgene: CDH2	Kegg: 1000	H-InvDB: CDH2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDH2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDH2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CDH2 gene
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Patent Information for CDH2 gene:
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GeneCards and IP:
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cadherin 2, type 1, N-cadherin (neuronal)

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CDH2 Gene

cadherin 2, type 1, N-cadherin (neuronal)

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