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CDH2 Gene

protein-coding   GIFtS: 73
GCID: GC18M025530

Cadherin 2, Type 1, N-Cadherin (Neuronal)


(Previous symbol: NCAD)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cadherin 2, Type 1, N-Cadherin (Neuronal)1 2     Cadherin 2, N-Cadherin (Neuronal)2
NCAD1 2 3 5     cadherin-22
N-cadherin1 3     Calcium-Dependent Adhesion Protein, Neuronal2
Neural Cadherin2 3     N-Cadherin 12
CDHN2 3     neural-cadherin2
CDw3252 3     CD325 Antigen3
CD3252     

External Ids:    HGNC: 17591   Entrez Gene: 10002   Ensembl: ENSG000001705587   OMIM: 1140205   UniProtKB: P190223   

Export aliases for CDH2 gene to outside databases

Previous GC identifers: GC18M025465 GC18M025261 GC18M023782 GC18M023784 GC18M022383


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDH2 Gene:
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent
cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a
highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of
left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is
mediated at least in part by this gene product. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDH2 Gene:
CDH2 (cadherin 2, type 1, N-cadherin (neuronal)) is a protein-coding gene. Diseases associated with CDH2 include hypoplastic left heart syndrome, and malignant mesothelioma. GO annotations related to this gene include protein phosphatase binding and calcium ion binding. An important paralog of this gene is DSC1.

UniProtKB/Swiss-Prot: CADH2_HUMAN, P19022
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell
types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic
spine density (By similarity)

Gene Wiki entry for CDH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDH2 gene promoter:
         Sp1   SRF (504 AA)   Nkx2-2   Nkx2-5   HNF-3beta   IRF-2   FOXO4   LyF-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDH2 promoter sequence
   Search Chromatin IP Primers for CDH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11.2   Ensembl cytogenetic band:  18q12.1   HGNC cytogenetic band: 18q12.1

CDH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M025530:  view genomic region     (about GC identifiers)

Start:
25,530,930 bp from pter      End:
25,757,445 bp from pter
Size:
226,516 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CADH2_HUMAN, P19022 (See protein sequence)
Recommended Name: Cadherin-2 precursor  
Size: 906 amino acids; 99809 Da
Subunit: Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1,
GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to
internalization through TAOK2/p38 MAPK pathway (By similarity)
Secondary accessions: B0YIY6 Q14923 Q8N173

Explore the universe of human proteins at neXtProt for CDH2: NX_P19022

Explore proteomics data for CDH2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys756
  • Glycosylation2 at Asn190, Asn273, Asn325, Asn402, Asn572, Asn651, Asn692
  • Modification sites at PhosphoSitePlus

  • See CDH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001783.2  
    ENSEMBL proteins: 
     ENSP00000269141   ENSP00000382312   ENSP00000411360   ENSP00000412120   ENSP00000414269  
    Reactome Protein details: P19022

    CDH2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CDH2 (N-Cadherin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CDH2
    OriGene Protein Over-expression Lysate for CDH2
    OriGene MassSpec for CDH2
    OriGene Custom Protein Services for CDH2
    GenScript Custom Purified and Recombinant Proteins Services for CDH2
    Novus Biologicals CDH2 Proteins
    Novus Biologicals CDH2 Lysate
    Sino Biological Recombinant Protein for CDH2
    Sino Biological Cell Lysate for CDH2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDH2

    CDH2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDH2
    R&D Systems Antibodies for CDH2 (N-Cadherin)
    Cell Signaling Technology (CST) Antibodies for CDH2 
    OriGene Antibodies for CDH2
    OriGene Custom Antibody Services for CDH2
    Novus Biologicals CDH2 Antibodies
    Abcam antibodies for CDH2
    Cloud-Clone Corp. Antibodies for CDH2
    ThermoFisher Antibody for CDH2
    LSBio Antibodies in human, mouse, rat for CDH2

    CDH2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDH2
    R&D Systems Proteome Profiler Antibody Arrays for CDH2 (N-Cadherin)
    GenScript Custom Assay Services for CDH2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDH2
    Cloud-Clone Corp. CLIAs for CDH2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MCDH: Cadherins / Major cadherins
    CD: CD molecules

    Selected InterPro protein domains (see all 7):
     IPR009124 Cadherin/Desmocollin
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR014868 Cadherin_pro_dom
     IPR020894 Cadherin_CS

    Graphical View of Domain Structure for InterPro Entry P19022

    ProtoNet protein and cluster: P19022

    3 Blocks protein domains:
    IPB000233 Cadherin cytoplasmic region
    IPB002126 Cadherin
    IPB009124 Desmocollin signature


    UniProtKB/Swiss-Prot: CADH2_HUMAN, P19022
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the
    connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied
    sequentially in the order of site 3, then site 2 and site 1 (By similarity)
    Similarity: Contains 5 cadherin domains


    CDH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CADH2_HUMAN, P19022
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
    a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell
    types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic
    spine density (By similarity)

         Genatlas biochemistry entry for CDH2:
    cadherin 2,N-cadherin,transmembrane glycoproteincomponent of adherens junction,containing a CCG repeat in
    5'utr,transmembrane glycoprotein component of adherens junction,expressed in brain,putatively involved in
    synaptic adhesion,axon outgrowth and guidance,also expressed in muscle

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI17057644
    GO:0008013beta-catenin binding TAS16344550
    GO:0019903protein phosphatase binding IEA--
    GO:0045294alpha-catenin binding IPI7650039
         
    CDH2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDH2:
     Decreased focal adhesion (FA)   Increased G2M DNA content 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cdh2):
     cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  muscle  nervous system 

    CDH2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdh2tm1Hyn for CDH2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDH2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDH2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDH2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDH2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDH2:
    hsa-mir-145-5p (MIRT007288), hsa-mir-204-5p (MIRT005821), hsa-mir-1 (MIRT024104), hsa-mir-194-5p (MIRT005889), hsa-mir-30a-5p (MIRT028671), hsa-mir-155-5p (MIRT021006), hsa-mir-124-3p (MIRT023197), hsa-mir-27b-5p (MIRT038654), hsa-mir-615-3p (MIRT040123), hsa-mir-138-5p (MIRT021684)

    Block miRNA regulation of human, mouse, rat CDH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDH2 (see all 95):
    hsa-miR-411* hsa-miR-520f hsa-miR-3607-3p hsa-miR-3938 hsa-miR-642a hsa-miR-411 hsa-miR-605 hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmidCDH2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDH2
    Predesigned siRNA for gene silencing in human, mouse, rat CDH2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CDH2

    Clone
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    OriGene clones in human, mouse for CDH2 (see all 7)
    OriGene ORF clones in mouse, rat for CDH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDH2 (NM_001792)
    Sino Biological Human cDNA Clone for CDH2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH2

    Cell Line
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    ESI BIO PureStem Progenitors for CDH2: 
    PureStem 4D20.8, NCr-fac Progenitor, PureStem E15, Meso-prx/latp Progenitor,
    PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CADH2_HUMAN, P19022: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton3
    extracellular2
    nucleus2
    peroxisome2
    endoplasmic reticulum1
    endosome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction IDA7650039
    GO:0005912adherens junction ----
    GO:0005913cell-cell adherens junction IDA19101069
    GO:0005916fascia adherens IEA--

    CDH2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDH2 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Arrhythmogenic right ventricular cardiomyopathy0.54
    2Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Adherens junctions interactions0.49
    3CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    4ERK Signaling
    Rho Family GTPases0.61
    ILK Signaling0.49
    5L1CAM interactions
    Developmental Biology0.63

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDH2 (see all 9)
        S-1P Stimulated Signaling
    G12-G13 in Cellular Signaling
    Epithelial Adherens Junctions
    ILK Signaling
    GSK3 Signaling

    1 Cell Signaling Technology (CST) Pathway for CDH2
        Adhesion

    3 GeneGo (Thomson Reuters) Pathways for CDH2
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Cadherin-mediated cell adhesion

    Selected BioSystems Pathways for CDH2 (see all 6)
        BDNF signaling pathway
    Neural Crest Differentiation
    Arrhythmogenic right ventricular cardiomyopathy
    N-cadherin signaling events
    FGF signaling pathway

    1 Sino Biological Pathway for CDH2
        Canonical Wnt Pathway

    2 Reactome Pathways for CDH2
        Adherens junctions interactions
    CDO in myogenesis


    2 Kegg Pathways  (Kegg details for CDH2):
        Cell adhesion molecules (CAMs)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)


    CDH2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDH2 (see all 7): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Adherens Junctions in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDH2 (P190221, 2, 3 ENSP000002691414) via UniProtKB, MINT, STRING, and/or I2D (see all 114)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN1P180312, 3, ENSP000003606834MINT-73487 MINT-73488 MINT-73489 I2D: score=3 STRING: ENSP00000360683
    CTNNB1P352221, 2, 3, ENSP000003444564EBI-2256711,EBI-491549 MINT-4085491 I2D: score=8 STRING: ENSP00000344456
    CTNND1O607163, ENSP000003820044I2D: score=4 STRING: ENSP00000382004
    ARVCFO001923, ENSP000002632074I2D: score=3 STRING: ENSP00000263207
    CDH4P552833, ENSP000003536564I2D: score=3 STRING: ENSP00000353656
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS2384753
    GO:0007156homophilic cell adhesion IEA--
    GO:0007157heterophilic cell-cell adhesion IEA--
    GO:0016339calcium-dependent cell-cell adhesion IEA--
    GO:0016477cell migration IEA--

    CDH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDH2 (CADH2)

    1 HMDB Compound for CDH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for CDH2 gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 42.5 4 11696444 (1), 10934323 (1), 19070520 (1)
    tyrosine 40.4 58 8707857 (8), 11106648 (4), 9786960 (2), 12377785 (2) (see all 30)
    paraffin 34.4 11 9191009 (1), 12657131 (1), 12800081 (1), 12204061 (1) (see all 11)
    neurocan 33.1 2 10583905 (2)
    swainsonine 22.1 3 14561752 (1)
    glycogen 20.2 3 17389597 (2), 9314542 (1)
    b 723 20 5 12883236 (3), 15188136 (2)
    cytochalasin d 19.2 1 12095980 (1)
    calcium 17.1 59 19162191 (5), 7962102 (3), 8090352 (3), 2303131 (2) (see all 25)
    phosphatidylinositol 16.2 6 12095980 (3), 19546217 (1)



    CDH2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDH2 gene: 
    NM_001792.3  

    Unigene Cluster for CDH2:

    Cadherin 2, type 1, N-cadherin (neuronal)
    Hs.464829  [show with all ESTs]
    Unigene Representative Sequence: NM_001792
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269141(uc010xbn.1 uc002kwg.2) ENST00000399380 ENST00000418492
    ENST00000430882 ENST00000413878
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat CDH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDH2 (see all 95):
    hsa-miR-411* hsa-miR-520f hsa-miR-3607-3p hsa-miR-3938 hsa-miR-642a hsa-miR-411 hsa-miR-605 hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmidCDH2 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDH2 (NM_001792)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH2
    Primer
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    OriGene qPCR primer pairs and template standards for CDH2
    OriGene qSTAR qPCR primer pairs in human, mouse for CDH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDH2
      QuantiTect SYBR Green Assays in human, mouse, rat CDH2
      QuantiFast Probe-based Assays in human, mouse, rat CDH2

    Additional mRNA sequence: 

    AK129728.1 AK302831.1 BC021695.1 BC036470.1 BX648579.1 M34064.1 S42303.1 X54315.1 
    X57548.1 

    5 DOTS entries:

    DT.414612  DT.92433029  DT.95273907  DT.121096711  DT.65288085 

    Selected AceView cDNA sequences (see all 137):

    CK725209 C04763 AI127140 BM893528 AA410423 AV705261 BG197310 AA653561 
    BM966740 AU132015 BM693820 BQ772138 AI611780 AL041311 BX955043 BE464612 
    AI064969 W49619 CK724900 BM670881 AL046467 BG749763 AI361474 BG498896 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDH2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:              -           -     -     -     -                                                                                                               
    SP2:                                      -     -                                                                                                               
    SP3:                                            -                                                                                                               
    SP4:                                                                                                                                                            
    SP5:                          -     -     -     -                                                                                                               


    ECgene alternative splicing isoforms for CDH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATATCTT
    CDH2 Expression
    About this image


    CDH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 33) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 22 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Eye (Sensory Organs)    fully expand to see all 14 entries
             Limbal Basal Epithelial Cells Limbus Epithelium
             Lens
             Human corneal endothelial cells
             RX+ Vesicle
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Bone (Muscoskeletal System)    fully expand to see all 17 entries
             Prechondrocytes Autopod Epiphyseal End
             Rib
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Pericytes Blood Brain Barrier
             Medulla Oblongata
    CDH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.464829
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDH2 (see all 7): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Adherens Junctions in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDH2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdh21 , 5 cadherin 21, 5 88.34(n)1
    96.8(a)1
      18 (10.10 cM)5
    125581  NM_007664.41  NP_031690.31 
     165888775 
    chicken
    (Gallus gallus)
    Aves CDH21 cadherin 2, type 1, N-cadherin (neuronal) 79.65(n)
    85.98(a)
      414745  NM_001001615.1  NP_001001615.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDH26
    cadherin 2, type 1, N-cadherin (neuronal)
    86(a)
    1 ↔ 1
    4(35844295-36003382)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.18732 X.laevis mRNA for N-cadherin (clone 1) 78.56(n)    X57675.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdh22 cadherin 2, neuronal 77.71(n)   30291  AF430842.1 


    ENSEMBL Gene Tree for CDH2 (if available)
    TreeFam Gene Tree for CDH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDH2 gene
    DSC12  CDH42  DSG42  DSG12  CDH132  CDH32  DSG22  CDH12  
    CDH262  DSC32  DSC22  CDH152  DSG32  
    Selected SIMAP similar genes for CDH2 using alignment to 5 protein entries:     CADH2_HUMAN (see all proteins) (see all similar genes):
    DKFZp434K1130    CDH4    CDH3    CDH1    CDH15    CDH13
    CDH10    CDH7    CDH8    CDH9    CDH11    CDH18
    CDH20    CDH6    CDH26    CDH24    CDH12    Nbla04261

    CDH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDH2 (see all 4826)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2014715171,2
    --22383737(+) AAAAA-/AAAC  
            
    AAACT
    1 -- ut310--------
    rs786346621,2
    C--22385766(+) CAGAA-/TTCAGT 1 -- int10--------
    rs803089291,2
    C--22392171(+) ACACAA/CACACA 1 -- int10--------
    rs174629761,2
    H--22443091(+) ATTCCC/TTTTTC 1 -- int1 trp34Minor allele frequency- T:0.00NS EA 418
    rs2007225071,2
    --22451009(+) ATATA-/TGTACAT 1 -- int10--------
    rs174684081,2
    C--22475598(+) ATATAA/TATATA 1 -- int10--------
    rs1920543901,2
    --22475618(+) ATATAA/TATATA 1 -- int10--------
    rs107098001,2
    C--22476879(+) TTGTC-/AAAAAA 1 -- int1 trp32Minor allele frequency- A:0.00NA CSA 4
    rs667653181,2
    C--22484625(+) AAAGG-/GAGAGAG 1 -- int10--------
    rs596529091,2
    C--22485328(+) CCATGT/-AATTG 1 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for CDH2 (25530930 - 25757445 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CDH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv9622CNV Loss18304495
    nsv833605CNV Gain17160897

    Human Gene Mutation Database (HGMD): CDH2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDH2
    DNA2.0 Custom Variant and Variant Library Synthesis for CDH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114020    OMIM disorders: --

    Selected diseases for CDH2 (see all 85):    
    About MalaCards
    hypoplastic left heart syndrome    malignant mesothelioma    pulmonary neuroendocrine tumor    desmoid tumor
    pseudomyxoma peritonei    atypical teratoid rhabdoid tumor    papillary adenocarcinoma    rhabdoid tumor
    chordoma    spindle cell carcinoma    craniosynostosis    leiomyoma
    tongue cancer    anaplastic astrocytoma    papillary renal cell carcinoma    fibromatosis
    astrocytoma    bladder carcinoma    neuroendocrine tumor    adrenocortical carcinoma

    1 disease from the University of Copenhagen DISEASES database for CDH2:
    Cancer

    CDH2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CDH2 gene (see all 76)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 54.1 64 19360298 (6), 12508543 (5), 20233707 (5), 12569568 (2) (see all 32)
    epithelial tumor 51.9 4 9191009 (1), 15262114 (1), 16258702 (1), 16596172 (1)
    tumors 50.9 181 16675571 (7), 20233707 (7), 9191009 (5), 18622386 (4) (see all 90)
    malignant mesothelioma 47.3 5 10849094 (2), 14595746 (1), 15717748 (1), 12194995 (1)
    melanoma 44 88 17668445 (6), 16371504 (5), 16784991 (5), 15316281 (4) (see all 34)
    ovarian carcinoma 41.1 6 11684957 (1), 17266044 (1), 16788982 (1), 18930836 (1) (see all 5)
    mesothelioma 39.9 20 14506634 (4), 8522310 (2), 15717748 (2), 9190996 (2) (see all 9)
    cancer 38.6 53 17371194 (3), 17414625 (2), 12526217 (2), 15717748 (2) (see all 31)
    carcinoma 37.7 39 14645693 (3), 16258702 (3), 20388391 (3), 11684957 (2) (see all 27)
    pleural malignant mesothelioma 36.6 10 10227598 (4), 8522310 (3), 9190996 (1)

    Genetic Association Database (GAD): CDH2
    Human Genome Epidemiology (HuGE) Navigator: CDH2 (5 documents)

    Export disorders for CDH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDH2 gene, integrated from 10 sources (see all 764):
    (articles sorted by number of sources associating them with CDH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene. (PubMed id 2384753)1, 2, 3, 9 Walsh F.S....Goodfellow P.N. (J. Neurochem. 1990)
    2. Human N-cadherin: nucleotide and deduced amino acid sequence. (PubMed id 2216790)1, 2, 3 Reid R.A. and Hemperly J.J. (Nucleic Acids Res. 1990)
    3. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. (PubMed id 21810271)1, 4 Antoni G....Tregouet D.A. (BMC Med. Genet. 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    6. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (Cancer Res. 2009)
    7. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    8. Adhesion signaling by a novel mitotic substrate of src kinases. (PubMed id 16007225)1, 2 Bhatt A.S.... Moasser M.M. (Oncogene 2005)
    9. Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene. (PubMed id 7731968)1, 3 Selig S....Kunkel L.M. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    10. Structure of the human N-cadherin gene: YAC analysis and fine chromosomal mapping to 18q11.2. (PubMed id 7959764)1, 2 Wallis J.A.... Walsh F.S. (Genomics 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1000 HGNC: 1759 AceView: CDH2 Ensembl:ENSG00000170558 euGenes: HUgn1000
    ECgene: CDH2 Kegg: 1000 H-InvDB: CDH2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDH2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDH2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDH2 gene:
    Search GeneIP for patents involving CDH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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