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Aliases for CDH2 Gene

Aliases for CDH2 Gene

  • Cadherin 2 2 3
  • Cadherin 2, Type 1, N-Cadherin (Neuronal) 2 3 5
  • Neural Cadherin 3 4
  • N-Cadherin 2 4
  • CDw325 3 4
  • NCAD 3 4
  • CDHN 3 4
  • Calcium-Dependent Adhesion Protein, Neuronal 3
  • CD325 Antigen 4
  • N-Cadherin 1 3
  • CD325 3

External Ids for CDH2 Gene

Previous HGNC Symbols for CDH2 Gene

  • NCAD

Previous GeneCards Identifiers for CDH2 Gene

  • GC18M025465
  • GC18M025261
  • GC18M023782
  • GC18M023784
  • GC18M022383
  • GC18M025530

Summaries for CDH2 Gene

Entrez Gene Summary for CDH2 Gene

  • This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]

GeneCards Summary for CDH2 Gene

CDH2 (Cadherin 2) is a Protein Coding gene. Diseases associated with CDH2 include Arrhythmogenic Right Ventricular Cardiomyopathy and Pseudomyxoma Peritonei. Among its related pathways are Cell junction organization and Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions. GO annotations related to this gene include calcium ion binding and protein phosphatase binding. An important paralog of this gene is DSG2.

UniProtKB/Swiss-Prot for CDH2 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

Gene Wiki entry for CDH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH2 Gene

Genomics for CDH2 Gene

Regulatory Elements for CDH2 Gene

Enhancers for CDH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDH2 on UCSC Golden Path with GeneCards custom track

Promoters for CDH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDH2 Gene

Chromosome:
18
Start:
27,932,879 bp from pter
End:
28,177,481 bp from pter
Size:
244,603 bases
Orientation:
Minus strand

Genomic View for CDH2 Gene

Genes around CDH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH2 Gene

Proteins for CDH2 Gene

  • Protein details for CDH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19022-CADH2_HUMAN
    Recommended name:
    Cadherin-2
    Protein Accession:
    P19022
    Secondary Accessions:
    • A8MWK3
    • B0YIY6
    • Q14923
    • Q8N173

    Protein attributes for CDH2 Gene

    Size:
    906 amino acids
    Molecular mass:
    99809 Da
    Quaternary structure:
    • Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway (By similarity).

    Alternative splice isoforms for CDH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH2 Gene

Proteomics data for CDH2 Gene at MOPED

Post-translational modifications for CDH2 Gene

  • Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).
  • Ubiquitination at Lys 756
  • Glycosylation at Asn 190, Asn 273, Asn 325, Asn 402, Asn 572, Asn 651, and Asn 692
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH2 Gene

No data available for DME Specific Peptides for CDH2 Gene

Domains & Families for CDH2 Gene

Gene Families for CDH2 Gene

Suggested Antigen Peptide Sequences for CDH2 Gene

Graphical View of Domain Structure for InterPro Entry

P19022

UniProtKB/Swiss-Prot:

CADH2_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 (By similarity).
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 (By similarity).
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH2: view

Function for CDH2 Gene

Molecular function for CDH2 Gene

GENATLAS Biochemistry:
cadherin 2,N-cadherin,transmembrane glycoproteincomponent of adherens junction,containing a CCG repeat in 5utr,transmembrane glycoprotein component of adherens junction,expressed in brain,putatively involved in synaptic adhesion,axon outgrowth and guidance,also expressed in muscle
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

Gene Ontology (GO) - Molecular Function for CDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045295 gamma-catenin binding IPI 7650039
genes like me logo Genes that share ontologies with CDH2: view
genes like me logo Genes that share phenotypes with CDH2: view

Animal Models for CDH2 Gene

MGI Knock Outs for CDH2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDH2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH2 Gene

Localization for CDH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH2 Gene

Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. {ECO:0000250 UniProtKB:P15116}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH2 Gene COMPARTMENTS Subcellular localization image for CDH2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 3
nucleus 2
peroxisome 2
cytosol 1
endoplasmic reticulum 1
endosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005911 cell-cell junction IDA 7650039
GO:0014704 intercalated disc ISS --
GO:0030864 colocalizes_with cortical actin cytoskeleton IDA 24046456
GO:0043234 protein complex IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with CDH2: view

Pathways & Interactions for CDH2 Gene

genes like me logo Genes that share pathways with CDH2: view

SIGNOR curated interactions for CDH2 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CDH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,TAS 2384753
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
GO:0009966 regulation of signal transduction IEA --
GO:0010001 glial cell differentiation ISS --
GO:0016477 cell migration IEA --
genes like me logo Genes that share ontologies with CDH2: view

Drugs & Compounds for CDH2 Gene

(20) Drugs for CDH2 Gene - From: ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ADH-1 Investigational Pharma 0
calcium Nutra 0
Cadherin Peptide, avian Pharma Role in cell adhesion 0

(22) Additional Compounds for CDH2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CDH2 Gene

Compound Action Cas Number
Cadherin Peptide, avian Role in cell adhesion 127650-08-2
genes like me logo Genes that share compounds with CDH2: view

Transcripts for CDH2 Gene

Unigene Clusters for CDH2 Gene

Cadherin 2, type 1, N-cadherin (neuronal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - -
SP2: - -
SP3: -
SP4:
SP5: - - - -
SP6: - - - - -
SP7: - - -

Relevant External Links for CDH2 Gene

GeneLoc Exon Structure for
CDH2
ECgene alternative splicing isoforms for
CDH2

Expression for CDH2 Gene

mRNA expression in normal human tissues for CDH2 Gene

mRNA differential expression in normal tissues according to GTEx for CDH2 Gene

This gene is overexpressed in Heart - Left Ventricle (x11.4), Heart - Atrial Appendage (x5.3), and Adrenal Gland (x4.4).

Protein differential expression in normal tissues from HIPED for CDH2 Gene

This gene is overexpressed in Amniocyte (33.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDH2 Gene



SOURCE GeneReport for Unigene cluster for CDH2 Gene Hs.464829

genes like me logo Genes that share expression patterns with CDH2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CDH2 Gene

Orthologs for CDH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDH2 35
  • 91.39 (n)
  • 97.13 (a)
CDH2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH2 35
  • 93.05 (n)
  • 98.34 (a)
NCAD 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh2 35
  • 88.34 (n)
  • 96.8 (a)
Cdh2 16
Cdh2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDH2 35
  • 99.63 (n)
  • 99.67 (a)
CDH2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh2 35
  • 87.2 (n)
  • 96.58 (a)
oppossum
(Monodelphis domestica)
Mammalia CDH2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH2 35
  • 79.65 (n)
  • 85.98 (a)
CDH2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh2 35
  • 74.12 (n)
  • 80.93 (a)
Str.2251 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1873 35
zebrafish
(Danio rerio)
Actinopterygii cdh2 35
  • 67.89 (n)
  • 72.97 (a)
cdh2 36
  • 72 (a)
OneToOne
Species with no ortholog for CDH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH2 Gene

ENSEMBL:
Gene Tree for CDH2 (if available)
TreeFam:
Gene Tree for CDH2 (if available)

Paralogs for CDH2 Gene

Paralogs for CDH2 Gene

genes like me logo Genes that share paralogs with CDH2: view

Variants for CDH2 Gene

Sequence variations from dbSNP and Humsavar for CDH2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs17495042 - 28,147,784(+) AGACG(C/T)CTGCA reference, missense, utr-variant-5-prime
rs17445840 - 28,013,730(+) TACTG(C/T)CACTT reference, missense
rs1041970 - 28,009,832(-) GTACA(C/G)TGTAA reference, missense
rs1041972 - 28,009,785(+) TCATT(A/C/G/T)TCAAC reference, missense
rs2289664 - 27,952,340(+) GGTCA(C/T)TGTCA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDH2 Gene

Variant ID Type Subtype PubMed ID
nsv833605 CNV Gain 17160897
nsv9622 CNV Loss 18304495

Variation tolerance for CDH2 Gene

Residual Variation Intolerance Score: 5.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH2 Gene

Human Gene Mutation Database (HGMD)
CDH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH2 Gene

Disorders for CDH2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for CDH2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
arrhythmogenic right ventricular cardiomyopathy
  • arrhythmogenic right ventricular dysplasia
pseudomyxoma peritonei
  • mucinous ascites
hypoplastic left heart syndrome
  • hlhs
mesothelioma, somatic
  • malignant mesothelioma
pulmonary neuroendocrine tumor
  • neuroendocrine neoplasm of lung
- elite association - COSMIC cancer census association via MalaCards
Search CDH2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDH2

Genetic Association Database (GAD)
CDH2
Human Genome Epidemiology (HuGE) Navigator
CDH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH2
genes like me logo Genes that share disorders with CDH2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH2 Gene

Publications for CDH2 Gene

  1. N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene. (PMID: 2384753) Walsh F.S. … Goodfellow P.N. (J. Neurochem. 1990) 2 3 4 23 67
  2. Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines. (PMID: 19070520) Wallerand H. … Reiter R.R. (Urol. Oncol. 2010) 3 23
  3. N-cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells. (PMID: 20116358) Wein F. … Wagner W. (Stem Cell Res 2010) 3 23
  4. [Role of N-cadherin in maintaining leukemic stem cell properties]. (PMID: 20137108) Zhi L. … Wang J.X. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010) 3 23
  5. N-cadherin increases after androgen deprivation and is associated with metastasis in prostate cancer. (PMID: 20233707) Jennbacken K. … WelAcn K. (Endocr. Relat. Cancer 2010) 3 23

Products for CDH2 Gene

Sources for CDH2 Gene

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