Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDH19 Gene

Aliases for CDH19 Gene

  • Cadherin 19 2 3
  • Cadherin 19, Type 2 2 3 5
  • CDH7L2 3 4
  • CDH7 3

External Ids for CDH19 Gene

Previous GeneCards Identifiers for CDH19 Gene

  • GC18M064016
  • GC18M064254
  • GC18M062320
  • GC18M062322
  • GC18M060871

Summaries for CDH19 Gene

Entrez Gene Summary for CDH19 Gene

  • This gene is one of three related type II cadherin genes situated in a cluster on chromosome 18. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein containing five extracellular cadherin repeats. Loss of cadherins may be associated with cancer formation. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for CDH19 Gene

CDH19 (Cadherin 19) is a Protein Coding gene. Diseases associated with CDH19 include van maldergem syndrome 1. Among its related pathways are ERK Signaling and Cell junction organization. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH22.

UniProtKB/Swiss-Prot for CDH19 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH19 Gene

Genomics for CDH19 Gene

Regulatory Elements for CDH19 Gene

Genomic Location for CDH19 Gene

Chromosome:
18
Start:
66,501,083 bp from pter
End:
66,604,138 bp from pter
Size:
103,056 bases
Orientation:
Minus strand

Genomic View for CDH19 Gene

Genes around CDH19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH19 Gene

Proteins for CDH19 Gene

  • Protein details for CDH19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H159-CAD19_HUMAN
    Recommended name:
    Cadherin-19
    Protein Accession:
    Q9H159
    Secondary Accessions:
    • B4E1V5
    • F5H1K0

    Protein attributes for CDH19 Gene

    Size:
    772 amino acids
    Molecular mass:
    87002 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDH19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH19 Gene

Proteomics data for CDH19 Gene at MOPED

Post-translational modifications for CDH19 Gene

  • Glycosylation at Asn 57, Asn 74, Asn 419, Asn 437, Asn 508, Asn 515, Asn 516, and Asn 534
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH19 Gene

No data available for DME Specific Peptides for CDH19 Gene

Domains & Families for CDH19 Gene

Gene Families for CDH19 Gene

Suggested Antigen Peptide Sequences for CDH19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H159

UniProtKB/Swiss-Prot:

CAD19_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH19: view

Function for CDH19 Gene

Molecular function for CDH19 Gene

UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
genes like me logo Genes that share phenotypes with CDH19: view

Animal Model Products

miRNA for CDH19 Gene

miRTarBase miRNAs that target CDH19

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDH19 Gene

Localization for CDH19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH19 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH19 Gene COMPARTMENTS Subcellular localization image for CDH19 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CDH19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH19: view

Pathways & Interactions for CDH19 Gene

genes like me logo Genes that share pathways with CDH19: view

Gene Ontology (GO) - Biological Process for CDH19 Gene

None

No data available for SIGNOR curated interactions for CDH19 Gene

Drugs & Compounds for CDH19 Gene

(1) Drugs for CDH19 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH19: view

Transcripts for CDH19 Gene

Unigene Clusters for CDH19 Gene

Cadherin 19, type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH19 Gene

No ASD Table

Relevant External Links for CDH19 Gene

GeneLoc Exon Structure for
CDH19
ECgene alternative splicing isoforms for
CDH19

Expression for CDH19 Gene

mRNA expression in normal human tissues for CDH19 Gene

mRNA differential expression in normal tissues according to GTEx for CDH19 Gene

This gene is overexpressed in Nerve - Tibial (x14.4) and Heart - Atrial Appendage (x7.7).

Protein differential expression in normal tissues from HIPED for CDH19 Gene

This gene is overexpressed in Retina (35.1) and Monocytes (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH19 Gene



SOURCE GeneReport for Unigene cluster for CDH19 Gene Hs.42771

mRNA Expression by UniProt/SwissProt for CDH19 Gene

Q9H159-CAD19_HUMAN
Tissue specificity: Expressed in many tissues, with the exception of uterus.
genes like me logo Genes that share expression patterns with CDH19: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CDH19 Gene

Orthologs for CDH19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH19 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CDH19 35
  • 88.48 (n)
  • 87.66 (a)
CDH19 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh19 35
  • 78.61 (n)
  • 75.32 (a)
Cdh19 16
Cdh19 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDH19 35
  • 99.44 (n)
  • 99.09 (a)
CDH19 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh19 35
  • 78.57 (n)
  • 76.36 (a)
cow
(Bos Taurus)
Mammalia CDH19 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDH19 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH19 35
  • 66.27 (n)
  • 58.25 (a)
CAD19 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH19 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh19 35
  • 62.64 (n)
  • 55.26 (a)
zebrafish
(Danio rerio)
Actinopterygii CDH19 36
  • 42 (a)
OneToOne
Species with no ortholog for CDH19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH19 Gene

ENSEMBL:
Gene Tree for CDH19 (if available)
TreeFam:
Gene Tree for CDH19 (if available)

Paralogs for CDH19 Gene

Paralogs for CDH19 Gene

genes like me logo Genes that share paralogs with CDH19: view

Variants for CDH19 Gene

Sequence variations from dbSNP and Humsavar for CDH19 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs483267 -- 66,550,464(-) attct(C/T)ttttg intron-variant
rs487514 -- 66,604,683(-) TTATG(A/T)TAAAT upstream-variant-2KB
rs535194 -- 66,539,844(+) CATGT(A/G)TATGT intron-variant
rs489253 -- 66,541,876(-) AAGGT(A/G)CAACC intron-variant
rs537578 -- 66,556,435(+) ccctc(C/T)tcata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH19 Gene

Variant ID Type Subtype PubMed ID
nsv458102 CNV Loss 19166990
nsv458104 CNV Loss 19166990
dgv3430n71 CNV Gain 21882294
dgv1041e1 CNV Complex 17122850
nsv909738 CNV Loss 21882294
nsv521111 CNV Gain 19592680
esv7054 CNV Gain 19470904
dgv555n67 CNV Loss 20364138
nsv821348 CNV Deletion 20802225
esv2717237 CNV Deletion 23290073
nsv820231 CNV Gain 19587683
esv2668897 CNV Deletion 23128226
esv21881 CNV Gain+Loss 19812545
nsv909739 CNV Loss 21882294

Variation tolerance for CDH19 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH19 Gene

HapMap Linkage Disequilibrium report
CDH19
Human Gene Mutation Database (HGMD)
CDH19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH19 Gene

Disorders for CDH19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDH19 Gene - From: OMIM

Disorder Aliases PubMed IDs
van maldergem syndrome 1
  • cerebro-facio-articular syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CDH19 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDH19

Genetic Association Database (GAD)
CDH19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH19
genes like me logo Genes that share disorders with CDH19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH19 Gene

Publications for CDH19 Gene

  1. Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7. (PMID: 10995570) Kools P. … van Roy F. (Genomics 2000) 2 3 4 23 67
  2. A novel locus for ectodermal dysplasia of hairs, nails and teeth type maps to chromosome 18q22.1-22.3. (PMID: 18184143) Tariq M. … Ahmad W. (Ann. Hum. Genet. 2008) 3 23
  3. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (PMID: 25189868) Sung Y.J. … Rao D.C. (Am. J. Hypertens. 2015) 3
  4. Myelin-forming cell-specific cadherin-19 is a marker for minimally infiltrative glioblastoma stem-like cells. (PMID: 25361488) Zorniak M. … Kuo J.S. (J. Neurosurg. 2015) 3
  5. A maternally inherited chromosome 18q22.1 deletion in a male with late-presenting diaphragmatic hernia and microphthalmia-evaluation of DSEL as a candidate gene for the diaphragmatic defect. (PMID: 20358601) Zayed H. … Slavotinek A.M. (Am. J. Med. Genet. A 2010) 3

Products for CDH19 Gene

Sources for CDH19 Gene

Back to Top

Content