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CDH19 Gene

protein-coding   GIFtS: 54
GCID: GC18M064254

Cadherin 19, Type 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cadherin 19, Type 21 2
CDH7L22 3
CDH72 5
cadherin-192

External Ids:    HGNC: 17581   Entrez Gene: 285132   Ensembl: ENSG000000719917   OMIM: 6030165   UniProtKB: Q9H1593   

Export aliases for CDH19 gene to outside databases

Previous GC identifers: GC18M064016 GC18M062320 GC18M062322 GC18M060871


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDH19 Gene:
This gene is one of three related type II cadherin genes situated in a cluster on chromosome 18. The encoded
protein is a calcium dependent cell-cell adhesion glycoprotein containing five extracellular cadherin repeats.
Loss of cadherins may be associated with cancer formation. Alternative splicing results in multiple transcript
variants for this gene. (provided by RefSeq, Aug 2012)

GeneCards Summary for CDH19 Gene:
CDH19 (cadherin 19, type 2) is a protein-coding gene. Diseases associated with CDH19 include van maldergem syndrome 1, and congenital diaphragmatic hernia. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH18.

UniProtKB/Swiss-Prot: CAD19_HUMAN, Q9H159
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDH19 gene promoter:
         C/EBPbeta   p53   FOXD3   CUTL1   GATA-1   MEF-2A   SRY   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDH19 promoter sequence
   Search Chromatin IP Primers for CDH19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDH19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.1   Ensembl cytogenetic band:  18q22.1   HGNC cytogenetic band: 18q22.1

CDH19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH19 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M064254:  view genomic region     (about GC identifiers)

Start:
64,168,320 bp from pter      End:
64,271,375 bp from pter
Size:
103,056 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CAD19_HUMAN, Q9H159 (See protein sequence)
Recommended Name: Cadherin-19 precursor  
Size: 772 amino acids; 87002 Da
Secondary accessions: B4E1V5 F5H1K0
Alternative splicing: 2 isoforms:  Q9H159-1   Q9H159-2   

Explore the universe of human proteins at neXtProt for CDH19: NX_Q9H159

Explore proteomics data for CDH19 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn57, Asn74, Asn419, Asn437, Asn508, Asn515, Asn516, Asn534
  • Modification sites at PhosphoSitePlus

  • See CDH19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001257957.1  NP_066976.1  

    ENSEMBL proteins: 
     ENSP00000262150   ENSP00000463085   ENSP00000439593   ENSP00000401998   ENSP00000464477  

    CDH19 Human Recombinant Protein Products:

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    Novus Biologicals CDH19 Proteins
    Novus Biologicals CDH19 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CDH19

    CDH19 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for CDH19 at Abcam
    Cloud-Clone Corp. Antibodies for CDH19
    Search ThermoFisher Antibodies for CDH19
    LSBio Antibodies in human, mouse, rat for CDH19

    CDH19 Assay Products:

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    GenScript Custom Assay Services for CDH19
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDH19
    Cloud-Clone Corp. CLIAs for CDH19


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MCDH: Cadherins / Major cadherins

    5 InterPro protein domains:
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR027397 Catenin_binding_dom
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q9H159

    ProtoNet protein and cluster: Q9H159

    2 Blocks protein domains:
    IPB000233 Cadherin cytoplasmic region
    IPB002126 Cadherin


    UniProtKB/Swiss-Prot: CAD19_HUMAN, Q9H159
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the
    connections, imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 5 cadherin domains


    CDH19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAD19_HUMAN, Q9H159
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
    a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    CDH19 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDH19:
     Decreased POU5F1-GFP protein e  Decreased number of cells in m 

         1 MGI phenotypic allele for Cdh19 (no phenotypes)

    CDH19 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdh19tm1Lex for CDH19

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDH19
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDH19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDH19
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDH19

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDH19:
    hsa-mir-335-5p (MIRT018515)

    Block miRNA regulation of human, mouse, rat CDH19 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CDH19
    SwitchGear 3'UTR luciferase reporter plasmidCDH19 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CDH19

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    GenScript: all cDNA clones in your preferred vector: CDH19 (NM_021153)
    Sino Biological Human cDNA Clone for CDH19
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDH19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH19

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CDH19
    ESI BIO PureStem Progenitor for CDH19: 
    PureStem 4D20.8, NCr-fac Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH19


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAD19_HUMAN, Q9H159: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    CDH19 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDH19 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    Rho Family GTPases0.61
    ILK Signaling0.49
    2Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    3WNT Signaling
    WNT Signaling
    4S-1P Stimulated Signaling
    S-1P Stimulated Signaling
    5Presenilin-Mediated Signaling
    Presenilin-Mediated Signaling

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDH19 (see all 7)
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    Presenilin-Mediated Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDH19
    Interactions:

        Search GeneGlobe Interaction Network for CDH19

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CDH19 (Q9H1593 ENSP000002621504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDH6P552853, ENSP000002650714I2D: score=1 STRING: ENSP00000265071
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion IEA--
    GO:0016337cell-cell adhesion ----

    CDH19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDH19 (CAD19)

    1 HMDB Compound for CDH19    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDH19 gene (2 alternative transcripts): 
    NM_001271028.1  NM_021153.3  

    Unigene Cluster for CDH19:

    Cadherin 19, type 2
    Hs.42771  [show with all ESTs]
    Unigene Representative Sequence: NM_021153
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262150(uc002lkc.1 uc010dql.1 uc010xey.1) ENST00000579658
    ENST00000540086 ENST00000454642(uc002lkd.3) ENST00000580157
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDH19 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CDH19
    SwitchGear 3'UTR luciferase reporter plasmidCDH19 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDH19
    Predesigned siRNA for gene silencing in human, mouse, rat CDH19
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    GenScript: all cDNA clones in your preferred vector: CDH19 (NM_021153)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDH19
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH19
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CDH19
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDH19
      QuantiTect SYBR Green Assays in human, mouse, rat CDH19
      QuantiFast Probe-based Assays in human, mouse, rat CDH19

    Additional mRNA sequence: 

    AF047826.1 AJ007607.1 AK304000.1 AK315257.1 AY358654.1 BC015877.1 NR_073130.1 

    3 DOTS entries:

    DT.409425  DT.110177  DT.107845 

    Selected AceView cDNA sequences (see all 49):

    NM_021153 AA252219 BC015877 H83907 AA452293 AI168815 AY358654 AI086159 
    CF551953 BP362933 AA402437 AJ007607 CD678375 CD679019 H80039 BF475561 
    AA398394 AL601420 BX093124 AJ712107 BG568716 AA252218 BQ718220 AA331759 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDH19 expression in normal human tissues (normalized intensities)      CDH19 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTACCACA
    CDH19 Expression
    About this image


    CDH19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Schwann Precursor Cells Peripheral Nerve Domain
             Schwann-like cells
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced 4D20.8 cells
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Mature Cardiac Fibroblasts Myocardium
             Atrioventricular Node
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 4D20.8, NCr-fac Progenitor
    CDH19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDH19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.42771

    UniProtKB/Swiss-Prot: CAD19_HUMAN, Q9H159
    Tissue specificity: Expressed in many tissues, with the exception of uterus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDH19 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdh191 , 5 cadherin 19, type 21, 5 78.61(n)1
    75.32(a)1
      1 (50.78 cM)5
    2274851  NM_001081386.11  NP_001074855.11 
     1108891955 
    chicken
    (Gallus gallus)
    Aves CDH191 cadherin 19, type 2 66.27(n)
    58.25(a)
      421029  NM_001100287.1  NP_001093757.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDH196
    cadherin 19, type 2
    50(a)
    1 ↔ 1
    4(45176524-45265168)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdh191 cadherin 19, type 2 62.64(n)
    55.26(a)
      100493723  XM_002939616.2  XP_002939662.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CDH196
    cadherin 19, type 2
    42(a)
    1 ↔ 1
    24(2096-12812) ENSDARG00000074991


    ENSEMBL Gene Tree for CDH19 (if available)
    TreeFam Gene Tree for CDH19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDH19 gene
    CDH182  CDH222  CDH102  CDH112  CDH72  CDH92  CDH62  CDH122  
    CDH82  CDH242  CDH202  CDH52  
    Selected SIMAP similar genes for CDH19 using alignment to 4 protein entries:     CAD19_HUMAN (see all proteins) (see all similar genes):
    CDH9    CDH7    CDH10    CDH20    CDH6    CDH11
    Nbla04261    CDH18    CDH8    CDH22    CDH12    CDH24
    CDH17    FAT3    CDH1    ME5    CDH5    CDH2

    CDH19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDH19 (see all 2080)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472828971,2
    C--64167968(+) CTTTT-/ACTA  
            
    TCAAA
    3 -- ds50010--------
    rs19433191,2
    C,F,H--64168000(+) ATCTTG/CAAGCC 3 -- ds500117Minor allele frequency- C:0.02NS EA NA WA CSA 795
    rs1471323531,2
    --64168100(+) GGCACA/GTGATT 3 -- ds50010--------
    rs1410364461,2
    --64168273(+) AAAGAC/TTCTGA 3 -- ds50010--------
    rs792362221,2
    F--64168525(+) TTAAGG/AGTTAC 3 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.05WA 118
    rs9488201,2
    H--64168593(+) AGCAAG/AACAAA 3 -- ut31 nc-transcript-variant4Minor allele frequency- A:0.00NS EA 420
    rs1498402461,2
    --64168603(+) AGCCAC/GGGTCA 3 -- ut31 nc-transcript-variant0--------
    rs1866151861,2
    --64168661(+) CCTGAA/TTGAAG 3 -- ut31 nc-transcript-variant0--------
    rs1925232451,2
    --64168928(+) AGTTAC/TATTTT 3 -- ut31 nc-transcript-variant0--------
    rs1458131941,2
    C--64168997(+) CCATGC/TGAAAT 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for CDH19 (64168320 - 64271375 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CDH19 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717237CNV Deletion23290073
    nsv821348CNV Deletion20802225
    esv2668897CNV Deletion23128226
    nsv909738CNV Loss21882294
    dgv555n67CNV Loss20364138
    nsv458104CNV Loss19166990
    nsv458102CNV Loss19166990
    nsv909739CNV Loss21882294
    nsv820231CNV Gain19587683
    dgv3430n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): CDH19
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDH19
    DNA2.0 Custom Variant and Variant Library Synthesis for CDH19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603016    OMIM disorders: --

    5 diseases for CDH19:    About MalaCards
    van maldergem syndrome 1    congenital diaphragmatic hernia    ectodermal dysplasia    microphthalmia
    squamous cell carcinoma


    CDH19 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDH19

    Export disorders for CDH19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDH19 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with CDH19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of three novel human cadherin genes (CDH7, CDH19, and CDH20) clustered on chromosome 18q22-q23 and with high homology to chicken cadherin-7. (PubMed id 10995570)1, 2, 3, 9 Kools P.... van Roy F. (Genomics 2000)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. A novel locus for ectodermal dysplasia of hairs, nails and teeth type maps to chromosome 18q22.1-22.3. (PubMed id 18184143)1, 9 Tariq M....Ahmad W. (Ann. Hum. Genet. 2008)
    4. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
    5. A maternally inherited chromosome 18q22.1 deletion in a male with late-presenting diaphragmatic hernia and microphthalmia-evaluation of DSEL as a candidate gene for the diaphragmatic defect. (PubMed id 20358601)1 Zayed H....Slavotinek A.M. (Am. J. Med. Genet. A 2010)
    6. Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP). (PubMed id 18364357)1 Niu J.... Kolattukudy P.E. (J. Biol. Chem. 2008)
    7. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)
    8. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    9. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28513 HGNC: 1758 AceView: CDH19 Ensembl:ENSG00000071991 euGenes: HUgn28513
    ECgene: CDH19 H-InvDB: CDH19

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDH19 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDH19 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDH19 gene:
    Search GeneIP for patents involving CDH19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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