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Aliases for CDH18 Gene

Aliases for CDH18 Gene

  • Cadherin 18, Type 2 2 3
  • CDH14 3 4 6
  • Cadherin-14 3 4
  • Cadherin-Like 24 3
  • Cadherin-18 3
  • Ey-Cadherin 3
  • CDH14L 3
  • CDH24 3

External Ids for CDH18 Gene

Summaries for CDH18 Gene

Entrez Gene Summary for CDH18 Gene

  • This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for CDH18 Gene

CDH18 (Cadherin 18, Type 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH19.

UniProtKB/Swiss-Prot for CDH18 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH18 Gene

Genomics for CDH18 Gene

Genomic Location for CDH18 Gene

19,472,951 bp from pter
20,575,873 bp from pter
1,102,923 bases
Minus strand

Genomic View for CDH18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDH18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH18 Gene

Proteins for CDH18 Gene

  • Protein details for CDH18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K0I2
    • B4DHG6
    • Q8N5Z2

    Protein attributes for CDH18 Gene

    790 amino acids
    Molecular mass:
    88073 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDH18 Gene


neXtProt entry for CDH18 Gene

Proteomics data for CDH18 Gene at MOPED

Post-translational modifications for CDH18 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn36, Asn255, Asn455, and Asn536

Other Protein References for CDH18 Gene

No data available for DME Specific Peptides for CDH18 Gene

Domains for CDH18 Gene

Gene Families for CDH18 Gene

  • MCDH :Cadherins / Major cadherins

Suggested Antigen Peptide Sequences for CDH18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.:
    • Q13634
  • Contains 5 cadherin domains.:
    • Q13634
genes like me logo Genes that share domains with CDH18: view

Function for CDH18 Gene

Molecular function for CDH18 Gene

GENATLAS Biochemistry: cadherin 18,R-cadherin,transmembrane glycoprotein cell adhesion molecule,expressed specifically in the central nervous system also in small cell lung carcinoma,putatively involved in synaptic adhesion,axon outgrowth and guidance
UniProtKB/Swiss-Prot Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Ontology (GO) - Molecular Function for CDH18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDH18: view

Phenotypes for CDH18 Gene

GenomeRNAi human phenotypes for CDH18:
genes like me logo Genes that share phenotypes with CDH18: view

miRNA for CDH18 Gene

miRTarBase miRNAs that target CDH18

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDH18 Gene

Localization for CDH18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH18 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CDH18 Gene COMPARTMENTS Subcellular localization image for CDH18 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDH18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH18: view

Pathways for CDH18 Gene

genes like me logo Genes that share pathways with CDH18: view

Gene Ontology (GO) - Biological Process for CDH18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0034329 cell junction assembly TAS --
GO:0034332 adherens junction organization TAS --
GO:0045216 cell-cell junction organization TAS --
genes like me logo Genes that share ontologies with CDH18: view

Compounds for CDH18 Gene

(1) HMDB Compounds for CDH18 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with CDH18: view

Transcripts for CDH18 Gene

Unigene Clusters for CDH18 Gene

Cadherin 18, type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH18 Gene

No ASD Table

Relevant External Links for CDH18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDH18 Gene

mRNA expression in normal human tissues for CDH18 Gene

mRNA differential expression in normal tissues according to GTEx for CDH18 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (9.8), Brain - Cerebellum (8.0), Brain - Frontal Cortex (BA9) (6.6), Brain - Cortex (5.4), Brain - Hypothalamus (4.7), and Brain - Anterior cingulate cortex (BA24) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDH18 Gene

SOURCE GeneReport for Unigene cluster for CDH18 Gene Hs.317632

genes like me logo Genes that share expressions with CDH18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CDH18 Gene

Orthologs for CDH18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDH18 35
  • 99.37 (n)
  • 99.62 (a)
CDH18 36
  • 100 (a)
(Bos Taurus)
Mammalia CDH18 35
  • 92.45 (n)
  • 97.09 (a)
CDH18 36
  • 97 (a)
(Canis familiaris)
Mammalia CDH18 35
  • 92.32 (n)
  • 97.22 (a)
CDH18 36
  • 97 (a)
(Mus musculus)
Mammalia Cdh18 35
  • 89.28 (n)
  • 96.08 (a)
Cdh18 16
Cdh18 36
  • 96 (a)
(Monodelphis domestica)
Mammalia CDH18 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia CDH18 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Cdh18 35
  • 90.21 (n)
  • 96.71 (a)
(Gallus gallus)
Aves CDH18 35
  • 82.78 (n)
  • 91.76 (a)
CDH18 36
  • 88 (a)
(Anolis carolinensis)
Reptilia CDH18 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488093 35
  • 77.34 (n)
  • 84.37 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7870 35
(Danio rerio)
Actinopterygii cdh18 36
  • 67 (a)
CDH18 (2 of 2) 36
  • 70 (a)
LOC100534833 35
  • 68.24 (n)
  • 69.81 (a)
Species with no ortholog for CDH18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH18 Gene

Gene Tree for CDH18 (if available)
Gene Tree for CDH18 (if available)

Paralogs for CDH18 Gene

Paralogs for CDH18 Gene

Selected SIMAP similar genes for CDH18 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDH18: view

Variants for CDH18 Gene

Sequence variations from dbSNP and Humsavar for CDH18 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs164448 -- 19,611,571(-) TCTCA(A/G)CTTTA intron-variant
rs164528 -- 19,612,229(-) TGTTC(A/G)GAGTT intron-variant
rs184717 -- 19,549,145(+) ccaat(A/G)ttgga intron-variant
rs189416 -- 19,523,516(+) taggc(A/T)aatat intron-variant
rs189492 -- 19,609,729(-) TTATA(C/T)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH18 Gene

Variant ID Type Subtype PubMed ID
nsv7369 OTHER Inversion 18451855
nsv470997 CNV Loss 18288195
nsv4752 CNV Insertion 18451855
dgv5965n71 CNV Loss 21882294
nsv881421 CNV Gain 21882294
nsv881242 CNV Loss 21882294
nsv462002 CNV Loss 19166990
nsv830224 CNV Loss 17160897
esv8395 CNV Gain 19470904
nsv880431 CNV Loss 21882294
nsv881061 CNV Loss 21882294
esv2729889 CNV Deletion 23290073
esv1636230 CNV Deletion 17803354
esv1002274 CNV Deletion 20482838
esv2729890 CNV Deletion 23290073
esv2729891 CNV Deletion 23290073
nsv328739 CNV Loss 16902084
esv2217776 CNV Deletion 18987734
esv2729892 CNV Deletion 23290073
esv2442104 CNV Deletion 19546169
dgv5966n71 CNV Loss 21882294
dgv5967n71 CNV Loss 21882294
esv2515726 CNV Deletion 19546169
esv2669398 CNV Deletion 23128226
nsv518192 CNV Loss 19592680

Relevant External Links for CDH18 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH18 Gene

Disorders for CDH18 Gene

Relevant External Links for CDH18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CDH18: view

No data available for UniProtKB/Swiss-Prot for CDH18 Gene

Publications for CDH18 Gene

  1. Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. (PMID: 9030594) Shibata T. … Hirohashi S. (J. Biol. Chem. 1997) 2 3 4
  2. Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. (PMID: 10191097) Chalmers I.J. … Atkinson M.J. (Genomics 1999) 2 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Genome-wide association scan of trait depression. (PMID: 20800221) Terracciano A. … Costa P.T. (Biol. Psychiatry 2010) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for CDH18 Gene

Sources for CDH18 Gene

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