Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CDH18 Gene

protein-coding   GIFtS: 61
GCID: GC05M019508

Cadherin 18, Type 2

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cadherin 18, Type 21 2     cadherin-182
CDH142 3 5     Cadherin-Like 242
CDH14L2     ey-cadherin2
CDH242     Cadherin-143
cadherin-142     

External Ids:    HGNC: 17571   Entrez Gene: 10162   Ensembl: ENSG000001455267   OMIM: 6030195   UniProtKB: Q136343   
ORGUL members:         

Export aliases for CDH18 gene to outside databases

Previous GC identifers: GC05M019421 GC05M019706 GC05M019518


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CDH18 Gene:
This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that
mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal
extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic
domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence
specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system
and is putatively involved in synaptic adhesion, axon outgrowth and guidance. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDH18 Gene:
CDH18 (cadherin 18, type 2) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH22.

UniProtKB/Swiss-Prot: CAD18_HUMAN, Q13634
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDH18 gene promoter:
         AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   STAT5A   POU3F2   HNF-3beta   AREB6   POU2F1   POU2F1a   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDH18 promoter sequence
   Search Chromatin IP Primers for CDH18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDH18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p14.3   Ensembl cytogenetic band:  5p14.3   HGNC cytogenetic band: 5p14.3

CDH18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH18 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M019508:  view genomic region     (about GC identifiers)

Start:
19,473,060 bp from pter      End:
20,575,982 bp from pter
Size:
1,102,923 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CAD18_HUMAN, Q13634 (See protein sequence)
Recommended Name: Cadherin-18 precursor  
Size: 790 amino acids; 88073 Da
Secondary accessions: A8K0I2 B4DHG6 Q8N5Z2
Alternative splicing: 2 isoforms:  Q13634-1   Q13634-2   

Explore the universe of human proteins at neXtProt for CDH18: NX_Q13634

Explore proteomics data for CDH18 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn36, Asn255, Asn455, Asn536
  • Modification sites at PhosphoSitePlus

  • See CDH18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161139.1  NP_004925.1  

    ENSEMBL proteins: 
     ENSP00000371710   ENSP00000425093   ENSP00000424931   ENSP00000422138   ENSP00000427383  
     ENSP00000425854   ENSP00000274170  
    Reactome Protein details: Q13634

    CDH18 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CDH18
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CDH18
    GenScript Custom Purified and Recombinant Proteins Services for CDH18
    Novus Biologicals CDH18 Proteins
    Novus Biologicals CDH18 Lysate
    Sino Biological Recombinant Protein for CDH18
    Sino Biological Cell Lysate for CDH18
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDH18

     
    Search eBioscience for Proteins for CDH18 

    CDH18 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CDH18
    OriGene Custom Antibody Services for CDH18
    Novus Biologicals CDH18 Antibodies
    Abcam antibodies for CDH18
    Cloud-Clone Corp. Antibodies for CDH18
    Search ThermoFisher Antibodies for CDH18
    LSBio Antibodies in human, mouse, rat for CDH18

    CDH18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDH18
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDH18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDH18
    Cloud-Clone Corp. CLIAs for CDH18
    Search eBioscience for ELISAs for CDH18 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    MCDH: Cadherins / Major cadherins

    5 InterPro protein domains:
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR027397 Catenin_binding_dom
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q13634

    ProtoNet protein and cluster: Q13634

    2 Blocks protein domains:
    IPB000233 Cadherin cytoplasmic region
    IPB002126 Cadherin


    UniProtKB/Swiss-Prot: CAD18_HUMAN, Q13634
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the
    connections, imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 5 cadherin domains


    Find genes that share domains with CDH18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAD18_HUMAN, Q13634
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
    a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

         Genatlas biochemistry entry for CDH18:
    cadherin 18,R-cadherin,transmembrane glycoprotein cell adhesion molecule,expressed specifically in the central
    nervous system also in small cell lung carcinoma,putatively involved in synaptic adhesion,axon outgrowth and
    guidance

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with CDH18           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CDH18:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDH18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDH18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDH18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDH18

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDH18:
    hsa-let-7e-5p (MIRT051690)

    Block miRNA regulation of human, mouse, rat CDH18 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CDH18
    SwitchGear 3'UTR luciferase reporter plasmidCDH18 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDH18
    Predesigned siRNA for gene silencing in human, mouse, rat CDH18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDH18

    Clone
    Products:
         
    OriGene clones in human, mouse for CDH18 (see all 11)
    OriGene ORF clones in mouse, rat for CDH18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDH18 (NM_004934)
    Sino Biological Human cDNA Clone for CDH18
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDH18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH18

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDH18
    Browse ESI BIO Cell Lines and PureStem Progenitors for CDH18 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CAD18_HUMAN, Q13634: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CDH18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CDH18 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Adherens junctions interactions0.49
    2ERK Signaling
    Rho Family GTPases0.61
    ILK Signaling0.49
    3Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    4WNT Signaling
    WNT Signaling
    5S-1P Stimulated Signaling
    S-1P Stimulated Signaling


    Find genes that share SuperPaths with CDH18           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDH18 (see all 7)
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    Presenilin-Mediated Signaling


    1 Reactome Pathway for CDH18
        Adherens junctions interactions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDH18
    Interactions:

        Search GeneGlobe Interaction Network for CDH18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for CDH18 (Q136343 ENSP000002741704) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDH9Q9ULB43, ENSP000002310214I2D: score=1 STRING: ENSP00000231021
    CDH6P552853, ENSP000002650714I2D: score=2 STRING: ENSP00000265071
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    CDH12P552893I2D: score=1 
    CDH10ENSP000002644634STRING: ENSP00000264463
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion IEA--
    GO:0034329cell junction assembly TAS--
    GO:0034332adherens junction organization TAS--
    GO:0045216cell-cell junction organization TAS--

    Find genes that share ontologies with CDH18           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDH18 (CAD18)

    1 HMDB Compound for CDH18    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CDH18 gene (2 alternative transcripts): 
    NM_001167667.1  NM_004934.3  

    Unigene Cluster for CDH18:

    Cadherin 18, type 2
    Hs.317632  [show with all ESTs]
    Unigene Representative Sequence: AK289547
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510297 ENST00000382275(uc011cnm.2 uc003jgd.3) ENST00000507958(uc003jgc.3)
    ENST00000506372 ENST00000502796 ENST00000515257 ENST00000511273 ENST00000508350
    ENST00000511423 ENST00000507632 ENST00000503132 ENST00000274170(uc021xwu.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDH18 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CDH18
    SwitchGear 3'UTR luciferase reporter plasmidCDH18 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CDH18
    Predesigned siRNA for gene silencing in human, mouse, rat CDH18
    Clone
    Products:
         
    OriGene clones in human, mouse for CDH18 (see all 11)
    OriGene ORF clones in mouse, rat for CDH18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDH18 (NM_004934)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDH18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH18
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CDH18
    OriGene qSTAR qPCR primer pairs in human, mouse for CDH18
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CDH18
      QuantiTect SYBR Green Assays in human, mouse, rat CDH18
      QuantiFast Probe-based Assays in human, mouse, rat CDH18

    Additional mRNA sequence: 

    AK289547.1 AK295087.1 AK308745.1 BC031051.1 U59325.1 

    3 DOTS entries:

    DT.453854  DT.92418714  DT.97798031 

    15 AceView cDNA sequences:

    CA425592 BM560363 AI204634 AA558942 BF963441 AI598174 BI670098 AA970045 
    BI603634 BF959886 BF947550 BF947605 CK005847 CB143074 AA501509 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CDH18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCGAAACTG
    CDH18 Expression
    About this image

    CDH18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDH18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.317632
        Custom PCR Arrays for CDH18
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDH18
    OriGene qSTAR qPCR primer pairs in human, mouse for CDH18
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CDH18
    QuantiTect SYBR Green Assays in human, mouse, rat CDH18
    QuantiFast Probe-based Assays in human, mouse, rat CDH18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CDH18 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdh181 , 5 cadherin 181, 5 89.28(n)1
    96.08(a)1
      15 (8.54 cM)5
    3208651  NM_001081299.11  NP_001074768.11 
     225490225 
    chicken
    (Gallus gallus)
    Aves CDH181 cadherin 18, type 2 82.78(n)
    91.76(a)
      428490  XM_426046.4  XP_426046.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDH186
    cadherin 18, type 2
    91(a)
    1 ↔ 1
    GL343195.1(7484452-7879096)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004880931 cadherin-18-like 77.34(n)
    84.37(a)
      100488093  XM_002933125.2  XP_002933171.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005348331 cadherin-18-like 68.24(n)
    69.81(a)
      100534833  XM_003199650.2  XP_003199698.2 


    ENSEMBL Gene Tree for CDH18 (if available)
    TreeFam Gene Tree for CDH18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CDH18 gene
    CDH222  CDH192  CDH102  CDH112  CDH72  CDH92  CDH62  CDH122  
    CDH82  CDH242  CDH52  CDH202  
    Selected SIMAP similar genes for CDH18 using alignment to 4 protein entries:     CAD18_HUMAN (see all proteins) (see all similar genes):
    CDH10    CDH6    Nbla04261    CDH9    CDH7    CDH20
    CDH8    CDH11    CDH24    CDH22    CDH12    CDH19
    FAT3    ME5    CDH5    CDH2    CDH4    CDH1

    Find genes that share paralogs with CDH18           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CDH18 (see all 10244)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1450791901,2
    --19472659(+) GTCTCA/GTGCTC 2 -- ds50010--------
    rs1388664501,2
    --19472815(+) CCTCAG/TGTAAT 2 -- ds50010--------
    rs1404763771,2
    C--19472837(+) ACAAGA/GCTAAT 2 -- ds50010--------
    rs1913782771,2
    --19472851(+) ATCTGA/TTATAA 2 -- ds50010--------
    rs7702971,2
    C,F,O,A,H--19472907(+) GAGGTT/CGTGAT 2 -- ds500126Minor allele frequency- C:0.40NA NS EA WA CSA 2492
    rs1504064081,2
    --19472946(+) TACCAC/TCCCTA 2 -- ds50010--------
    rs125170611,2
    C,F,H--19473029(+) TTGAAA/GCAAAT 2 -- ds500114Minor allele frequency- G:0.07NS EA NA WA CSA 1792
    rs1162717221,2
    F--19473055(+) AATTCA/TGGTAT 2 -- ds50011Minor allele frequency- T:0.05WA 118
    rs349726911,2
    C--19473140(+) TTGTC-/TTTTTT 2 -- ut310--------
    rs769789831,2
    C--19473158(+) TTTTAC/TTTTCT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CDH18 (19473060 - 19723060 bp, first 250kb of CDH18)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CDH18 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2729891CNV Deletion23290073
    esv2729890CNV Deletion23290073
    esv2729892CNV Deletion23290073
    esv2729889CNV Deletion23290073
    esv1002274CNV Deletion20482838
    esv2217776CNV Deletion18987734
    esv2515726CNV Deletion19546169
    esv2442104CNV Deletion19546169
    esv2669398CNV Deletion23128226
    esv1636230CNV Deletion17803354

    Human Gene Mutation Database (HGMD): CDH18
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDH18
    DNA2.0 Custom Variant and Variant Library Synthesis for CDH18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603019    OMIM disorders: --


    Find genes that share disorders with CDH18           About GenesLikeMe

    Genetic Association Database (GAD): CDH18
    Human Genome Epidemiology (HuGE) Navigator: CDH18 (2 documents)

    Export disorders for CDH18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CDH18 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with CDH18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. (PubMed id 9030594)1, 2, 3 Shibata T.... Hirohashi S. (J. Biol. Chem. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. (PubMed id 10191097)1, 3 Chalmers I.J....Atkinson M.J. (Genomics 1999)
    4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Genome-wide association scan of trait depression. (PubMed id 20800221)1 Terracciano A....Costa P.T. (Biol. Psychiatry 2010)
    7. [Expressions of cadherin molecules CDH18 and PCDH17 in human azoospermic testes]. (PubMed id 20180417)1 Yang B....Kang F.X. (Zhonghua Nan Ke Xue 2009)
    8. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    9. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    10. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1016 HGNC: 1757 AceView: CDH18 Ensembl:ENSG00000145526 euGenes: HUgn1016
    ECgene: CDH18 H-InvDB: CDH18

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CDH18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDH18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CDH18 gene:
    Search GeneIP for patents involving CDH18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CDH18   OriGene RNAi products in human, mouse, rat for CDH18  
     OriGene qPCR primer pairs and template standards for CDH18   OriGene Protein Over-expression Lysate for CDH18  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CDH18  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDH18   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CDH18   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDH18   OriGene Custom Protein Services for CDH18  

     
     
     Block miRNA regulation of human, mouse, rat CDH18 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CDH18
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDH18 Predesigned siRNA for gene silencing in human, mouse, rat CDH18
     QuantiFast Probe-based Assays in human, mouse, rat CDH18 QuantiTect SYBR Green Assays in human, mouse, rat CDH18
     Custom PCR Arrays for CDH18 Search Chromatin IP Primers for CDH18
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CDH18  Search GeneGlobe Interaction Network for CDH18
     Regulatory tfbs in CDH18 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CDH18 GenScript cDNA clones with any tag delivered in your preferred vector for CDH18
     GenScript Custom Assay Services for CDH18 GenScript Custom overexpressing Cell Line Services for CDH18
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CDH18 (CAD18)
     Proteins for CDH18
     Cell Lysates for CDH18
     cDNA Clones for CDH18
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CDH18 antibodies
     CDH18 proteins
     CDH18 lysates
     Antibodies for CDH18
     See all of Abcam's Antibodies, Kits and Proteins for CDH18
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CDH18
     Antibodies for CDH18
     ELISAs for CDH18
     CLIAs for CDH18



     Browse ESI BIO Cell Lines and PureStem Progenitors for CDH18
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH18
     SwitchGear 3'UTR luciferase reporter plasmids for CDH18
     SwitchGear Promoter luciferase reporter plasmids for CDH18
     Search ThermoFisher Antibodies for CDH18
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDH18
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDH18
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDH18
     LSBio Antibodies in human, mouse, rat for CDH18
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CDH18
      Search eBioscience for proteins for CDH18
      Search eBioscience for elisas for CDH18
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDH18 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4