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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDH18 Gene

protein-coding GIFtS: 56
GCID: GC05M019508

cadherin 18, type 2

Explore 4 diseases affiliated with
CDH18 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cadherin 18, Type 2¹ ²		Cadherin-14³
CDH14¹ ² ³ ⁵		Cadherin-18¹
EY-CADHERIN¹		Cadherin-Like 24²
CDH14L²		Ey-Cadherin¹
CDH24²		Cadherin-14³

External Ids:	HGNC: 1757¹	Entrez Gene: 1016²	Ensembl: ENSG00000145526⁷	OMIM: 603019⁵	UniProtKB: Q13634³

Export aliases for CDH18 gene to outside databases

Previous GC identifers: GC05M019421 GC05M019706 GC05M019518

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDH18:

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate

calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular

domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II

(atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I

cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved

in synaptic adhesion, axon outgrowth and guidance. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAD18_HUMAN, Q13634

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a

homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006576.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDH18 gene promoter:
AML1a POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) STAT5A POU3F2 HNF-3beta AREB6 POU2F1 POU2F1a IRF-7A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDH18 promoter sequence

Search SABiosciences Chromatin IP Primers for CDH18

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDH18

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p14.3 Ensembl cytogenetic band: 5p14.3 HGNC cytogenetic band: 5p14.3

CDH18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH18 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M019508: view genomic region (about GC identifiers)

Start:	19,473,060 bp from pter	End:	20,575,982 bp from pter
Size:	1,102,923 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAD18_HUMAN, Q13634 (See protein sequence)

Recommended Name: Cadherin-18 precursor

Size: 790 amino acids; 88073 Da

Subcellular location: Cell membrane; Single-pass type I membrane protein

Secondary accessions: A8K0I2 B4DHG6 Q8N5Z2

Alternative splicing: 2 isoforms: Q13634-1 Q13634-2

Explore the universe of human proteins at neXtProt for CDH18: NX_Q13634

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13634

CDH18 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001161139.1 NP_004925.1

ENSEMBL proteins:

ENSP00000371710 ENSP00000425093 ENSP00000424931 ENSP00000422138 ENSP00000427383

ENSP00000425854 ENSP00000444553 ENSP00000274170

Reactome Protein details: Q13634
Human Recombinant Protein Products for CDH18:

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	Uscn Proteins for CDH18

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

CDH18 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDH18 for domains About GeneDecksing

4 InterPro domains/families:

IPR000233 Cadherin_cytoplasmic-dom

IPR015919 Cadherin-like

IPR020894 Cadherin_CS

IPR002126 Cadherin

Graphical View of Domain Structure for InterPro Entry Q13634

ProtoNet protein and cluster: Q13634

2 Blocks protein families:

IPB000233 Cadherin cytoplasmic region

IPB002126 Cadherin

UniProtKB/Swiss-Prot: CAD18_HUMAN, Q13634

Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections,

imparting a strong curvature to the full-length ectodomain (By similarity)

Similarity: Contains 5 cadherin domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CAD18_HUMAN, Q13634

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a

homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Genatlas biochemistry entry for CDH18:

cadherin 18,R-cadherin,transmembrane glycoprotein cell adhesion molecule,expressed specifically in the central nervous

system also in small cell lung carcinoma,putatively involved in synaptic adhesion,axon outgrowth and guidance

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--

CDH18 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CDH18:

Decreased POU5F1-GFP protein e

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDH18

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH18

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell-cell junction organization

	Cell-cell junction organization	1.00			Adherens junctions interactions	0.51
	Cell junction organization	0.69			Cell-Cell communication	0.45

Rho Family GTPases

Rho Family GTPases

1.00

ILK Signaling

0.45

WNT Signaling

WNT Signaling

1.00

S-1P Stimulated Signaling

S-1P Stimulated Signaling

1.00

Presenilin-Mediated Signaling

Presenilin-Mediated Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDH18 (see all 7)

	S-1P Stimulated Signaling
	ILK Signaling
	GSK3 Signaling
	G12-G13 in Cellular Signaling
	Presenilin-Mediated Signaling

4 Reactome Pathways for CDH18

	Adherens junctions interactions
	Cell junction organization
	Cell-Cell communication
	Cell-cell junction organization

CDH18 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CDH18

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/19 Interacting proteins for CDH18 (Q13634³ ENSP00000274170⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDH9	Q9ULB4³, ENSP00000231021⁴	I2D: score=1 STRING: ENSP00000231021
CDH6	P55285³, ENSP00000265071⁴	I2D: score=2 STRING: ENSP00000265071
CTNNB1	P35222³, ENSP00000344456⁴	I2D: score=1 STRING: ENSP00000344456
CDH12	P55289³	I2D: score=1
CDH10	ENSP00000264463⁴	STRING: ENSP00000264463

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007156	homophilic cell adhesion	IEA	--
GO:0034329	cell junction assembly	TAS	--
GO:0034332	adherens junction organization	TAS	--
GO:0045216	cell-cell junction organization	TAS	--

CDH18 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDH18

1 HMDB Compound for CDH18 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about CDH18 / CAD18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDH18 gene (2 alternative transcripts):

NM_001167667.1 NM_004934.3

Unigene Cluster for CDH18:

Cadherin 18, type 2

Hs.317632 [show with all ESTs]

Unigene Representative Sequence: AK289547

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000510297 ENST00000382275(uc011cnm.2 uc003jgd.3) ENST00000507958(uc003jgc.3)

ENST00000506372 ENST00000502796 ENST00000515257 ENST00000511273 ENST00000508350

ENST00000511423 ENST00000507632 ENST00000503132 ENST00000542864 ENST00000274170(uc021xwu.1)

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Additional cDNA sequence:

AK289547.1 AK295087.1 AK308745.1 BC031051.1 U59325.1

3 DOTS entries:

DT.453854 DT.92418714 DT.97798031

15 AceView cDNA sequences:

BM560363 CA425592 AA558942 AI598174 BI670098 AA970045 BF963441 AI204634

BI603634 BF959886 BF947550 BF947605 CK005847 CB143074 AA501509

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDH18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCGAAACTG

About this image

CDH18 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDH18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDH18

SOURCE GeneReport for Unigene cluster: Hs.317632

SABiosciences Custom PCR Arrays for CDH18

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CDH18 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CDH18¹	cadherin 18, type 2	82.78(n) 91.76(a)		428490 XM_426046.3 XP_426046.3
lizard (Anolis carolinensis)	Reptilia	CDH18⁶ --	--	88(a) 81(a)	1 ↔ many 1 ↔ many	GL343195.1(7758409-7875929) GL343195.1(7691710-7694807)
zebrafish (Danio rerio)	Actinopterygii	LOC100534833¹	cadherin-18-like	68.18(n) 69.91(a)		100534833 XM_003199650.1 XP_003199698.1

ENSEMBL Gene Tree for CDH18 (if available)
TreeFam Gene Tree for CDH18 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDH18 gene

CDH4² DSG4² CDH3² CDH10² CDH11² CDH1² CDH6² DSC2²

CDH8² CDH20² CDH22² DSC1² CDH19² DSG1² CDH7² DSG2²

CDH9² CDH12² CDH26² DSC3² CDH2² CDH24² CDH15² CDH5²

DSG3²

18/20 SIMAP similar genes for CDH18 using alignment to 4 protein entries: CAD18_HUMAN (see all proteins) (see all similar genes):

CDH10 CDH6 Nbla04261 CDH9 CDH7 CDH20

CDH8 CDH11 CDH24 CDH22 CDH12 CDH19

FAT3 ME5 CDH5 CDH2 CDH4 CDH1

CDH18 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145079190^1,2		--	19472659(+)	`GTCTCA/GTGCTC`	2	--	ds500¹		0	--	--	--	--
rs138866450^1,2		--	19472815(+)	`CCTCAG/TGTAAT`	2	--	ds500¹		0	--	--	--	--
rs140476377^1,2		--	19472837(+)	`ACAAGA/GCTAAT`	2	--	ds500¹		0	--	--	--	--
rs191378277^1,2		--	19472851(+)	`ATCTGA/TTATAA`	2	--	ds500¹		0	--	--	--	--
rs770297^1,2	C,F,O,A,H	--	19472907(+)	`GAGGTT/CGTGAT`	2	--	ds500¹		26		NA NS EA WA CSA	2492
rs150406408^1,2		--	19472946(+)	`TACCAC/TCCCTA`	2	--	ds500¹		0	--	--	--	--
rs12517061^1,2	C,F,H	--	19473029(+)	`TTGAAA/GCAAAT`	2	--	ds500¹		14		NS EA NA WA CSA	1792
rs116271722^1,2	F	--	19473055(+)	`AATTCA/TGGTAT`	2	--	ds500¹		1		WA	118
rs34972691^1,2	C	--	19473140(+)	`TTGTC-/TTTTTT`	2	--	ut3¹		0	--	--	--	--
rs76978983^1,2	C	--	19473158(+)	`TTTTAC/TTTTCT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDH18 (19473060 - 19723060 bp, first 250kb of CDH18)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CDH18
3 CNVs: 99076 99075 4433
1 Indel: 60522

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDH18

DNA2.0 Custom Variant and Variant Library Synthesis for CDH18

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CDH18 for disorders           About GeneDecksing

OMIM gene information: 603019    OMIM disorders: --

4 diseases for CDH18:    About MalaCards

congenital diaphragmatic hernia hernia lung carcinoma carcinoma

Human Genome Epidemiology (HuGE) Navigator: CDH18 (2 documents)

Export disorders for CDH18 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CDH18 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with CDH18)

Utopia: connect your pdf to the dynamic
world of online information

Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. (PubMed id 9030594)^{1, 2, 3} Shibata T.... Hirohashi S. (1997)
Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. (PubMed id 10191097)^{1, 3} Chalmers I.J....Atkinson M.J. (1999)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Genome-wide association scan of trait depression. (PubMed id 20800221)¹ Terracciano A....Costa P.T. (2010)
[Expressions of cadherin molecules CDH18 and PCDH17 i n human azoospermic testes] (PubMed id 20180417)¹ Yang B....Kang F.X. (2009)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)² Schmutz J.... Rubin E.M. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1016	HGNC: 1757	AceView: CDH18	Ensembl:ENSG00000145526	euGenes: HUgn1016
ECgene: CDH18	H-InvDB: CDH18

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CDH18	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDH18	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CDH18 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CDH18 gene:
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GeneCards and IP:
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cadherin 18, type 2

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cadherin 18, type 2

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