Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDH18 Gene

Aliases for CDH18 Gene

  • Cadherin 18 2 3
  • Cadherin 18, Type 2 2 3 5
  • Cadherin-14 3 4
  • CDH14 3 4
  • Cadherin-Like 24 3
  • Ey-Cadherin 3
  • CDH14L 3
  • CDH24 3

External Ids for CDH18 Gene

Previous GeneCards Identifiers for CDH18 Gene

  • GC05M019421
  • GC05M019706
  • GC05M019518

Summaries for CDH18 Gene

Entrez Gene Summary for CDH18 Gene

  • This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for CDH18 Gene

CDH18 (Cadherin 18) is a Protein Coding gene. Among its related pathways are ERK Signaling and Cell junction organization. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH19.

UniProtKB/Swiss-Prot for CDH18 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH18 Gene

Genomics for CDH18 Gene

Genomic Location for CDH18 Gene

Chromosome:
5
Start:
19,472,930 bp from pter
End:
20,575,873 bp from pter
Size:
1,102,944 bases
Orientation:
Minus strand

Genomic View for CDH18 Gene

Genes around CDH18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH18 Gene

Proteins for CDH18 Gene

  • Protein details for CDH18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13634-CAD18_HUMAN
    Recommended name:
    Cadherin-18
    Protein Accession:
    Q13634
    Secondary Accessions:
    • A8K0I2
    • B4DHG6
    • Q8N5Z2

    Protein attributes for CDH18 Gene

    Size:
    790 amino acids
    Molecular mass:
    88073 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDH18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH18 Gene

Proteomics data for CDH18 Gene at MOPED

Post-translational modifications for CDH18 Gene

  • Glycosylation at Asn 36, Asn 255, Asn 455, and Asn 536
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CDH18 Gene

Domains & Families for CDH18 Gene

Gene Families for CDH18 Gene

Suggested Antigen Peptide Sequences for CDH18 Gene

Graphical View of Domain Structure for InterPro Entry

Q13634

UniProtKB/Swiss-Prot:

CAD18_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH18: view

Function for CDH18 Gene

Molecular function for CDH18 Gene

GENATLAS Biochemistry:
cadherin 18,R-cadherin,transmembrane glycoprotein cell adhesion molecule,expressed specifically in the central nervous system also in small cell lung carcinoma,putatively involved in synaptic adhesion,axon outgrowth and guidance
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
genes like me logo Genes that share phenotypes with CDH18: view

Animal Model Products

miRNA for CDH18 Gene

miRTarBase miRNAs that target CDH18

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDH18 Gene

Localization for CDH18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH18 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH18 Gene COMPARTMENTS Subcellular localization image for CDH18 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDH18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH18: view

Pathways & Interactions for CDH18 Gene

genes like me logo Genes that share pathways with CDH18: view

Gene Ontology (GO) - Biological Process for CDH18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0034332 adherens junction organization TAS --
GO:0045216 cell-cell junction organization TAS --
genes like me logo Genes that share ontologies with CDH18: view

No data available for SIGNOR curated interactions for CDH18 Gene

Drugs & Compounds for CDH18 Gene

(1) Drugs for CDH18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH18: view

Transcripts for CDH18 Gene

Unigene Clusters for CDH18 Gene

Cadherin 18, type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH18 Gene

No ASD Table

Relevant External Links for CDH18 Gene

GeneLoc Exon Structure for
CDH18
ECgene alternative splicing isoforms for
CDH18

Expression for CDH18 Gene

mRNA expression in normal human tissues for CDH18 Gene

mRNA differential expression in normal tissues according to GTEx for CDH18 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.8), Brain - Cerebellum (x8.0), Brain - Frontal Cortex (BA9) (x6.6), Brain - Cortex (x5.4), Brain - Hypothalamus (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.6).

Protein differential expression in normal tissues from HIPED for CDH18 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH18 Gene



SOURCE GeneReport for Unigene cluster for CDH18 Gene Hs.317632

genes like me logo Genes that share expression patterns with CDH18: view

Protein tissue co-expression partners for CDH18 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CDH18 Gene

Orthologs for CDH18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDH18 35
  • 92.45 (n)
  • 97.09 (a)
CDH18 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH18 35
  • 92.32 (n)
  • 97.22 (a)
CDH18 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh18 35
  • 89.28 (n)
  • 96.08 (a)
Cdh18 16
Cdh18 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDH18 35
  • 99.37 (n)
  • 99.62 (a)
CDH18 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh18 35
  • 90.21 (n)
  • 96.71 (a)
oppossum
(Monodelphis domestica)
Mammalia CDH18 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH18 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH18 35
  • 82.78 (n)
  • 91.76 (a)
CDH18 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH18 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488093 35
  • 77.34 (n)
  • 84.37 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100534833 35
  • 68.24 (n)
  • 69.81 (a)
cdh18 36
  • 67 (a)
OneToMany
CDH18 (2 of 2) 36
  • 70 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7870 35
Species with no ortholog for CDH18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH18 Gene

ENSEMBL:
Gene Tree for CDH18 (if available)
TreeFam:
Gene Tree for CDH18 (if available)

Paralogs for CDH18 Gene

Paralogs for CDH18 Gene

(20) SIMAP similar genes for CDH18 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDH18: view

Variants for CDH18 Gene

Sequence variations from dbSNP and Humsavar for CDH18 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs189416 -- 19,523,516(+) taggc(A/T)aatat intron-variant
rs189492 -- 19,609,729(-) TTATA(C/T)TTCTT intron-variant
rs164448 -- 19,611,571(-) TCTCA(A/G)CTTTA intron-variant
rs164528 -- 19,612,229(-) TGTTC(A/G)GAGTT intron-variant
rs184717 -- 19,549,145(+) ccaat(A/G)ttgga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH18 Gene

Variant ID Type Subtype PubMed ID
nsv7369 OTHER Inversion 18451855
nsv470997 CNV Loss 18288195
nsv4752 CNV Insertion 18451855
dgv5965n71 CNV Loss 21882294
nsv881421 CNV Gain 21882294
nsv881242 CNV Loss 21882294
nsv462002 CNV Loss 19166990
nsv830224 CNV Loss 17160897
esv8395 CNV Gain 19470904
nsv880431 CNV Loss 21882294
nsv881061 CNV Loss 21882294
esv2729889 CNV Deletion 23290073
esv1636230 CNV Deletion 17803354
esv1002274 CNV Deletion 20482838
esv2729890 CNV Deletion 23290073
esv2729891 CNV Deletion 23290073
nsv328739 CNV Loss 16902084
esv2217776 CNV Deletion 18987734
esv2729892 CNV Deletion 23290073
esv2442104 CNV Deletion 19546169
dgv5966n71 CNV Loss 21882294
dgv5967n71 CNV Loss 21882294
esv2515726 CNV Deletion 19546169
esv2669398 CNV Deletion 23128226
nsv518192 CNV Loss 19592680

Variation tolerance for CDH18 Gene

Residual Variation Intolerance Score: 3.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH18 Gene

HapMap Linkage Disequilibrium report
CDH18
Human Gene Mutation Database (HGMD)
CDH18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH18 Gene

Disorders for CDH18 Gene

Relevant External Links for CDH18

Genetic Association Database (GAD)
CDH18
Human Genome Epidemiology (HuGE) Navigator
CDH18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH18

No disorders were found for CDH18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDH18 Gene

Publications for CDH18 Gene

  1. Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. (PMID: 9030594) Shibata T. … Hirohashi S. (J. Biol. Chem. 1997) 2 3 4 67
  2. Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. (PMID: 10191097) Chalmers I.J. … Atkinson M.J. (Genomics 1999) 2 3
  3. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. (PMID: 25642632) Liu H. … Zhang F. (Nat. Genet. 2015) 3
  4. A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels. (PMID: 25240745) LA^pez S. … Soria J.M. (Mitochondrion 2014) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for CDH18 Gene

Sources for CDH18 Gene

Back to Top

Content