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Aliases for CDH17 Gene

Aliases for CDH17 Gene

  • Cadherin 17 2 3 5
  • Intestinal Peptide-Associated Transporter HPT-1 3 4
  • Cadherin 17, LI Cadherin (Liver-Intestine) 2 3
  • Liver-Intestine Cadherin 3 4
  • Human Intestinal Peptide-Associated Transporter HPT-1 3
  • Human Peptide Transporter 1 3
  • HPT-1 Cadherin 3
  • Cadherin-16 3
  • LI Cadherin 3
  • Cadherin-17 3
  • LI-Cadherin 4
  • CDH16 3
  • HPT-1 3
  • HPT1 3

External Ids for CDH17 Gene

Previous GeneCards Identifiers for CDH17 Gene

  • GC08M093885
  • GC08M094985
  • GC08M094808
  • GC08M095095
  • GC08M095208
  • GC08M090347

Summaries for CDH17 Gene

Entrez Gene Summary for CDH17 Gene

  • This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

GeneCards Summary for CDH17 Gene

CDH17 (Cadherin 17) is a Protein Coding gene. Diseases associated with CDH17 include Gastric Cancer and Van Maldergem Syndrome. Among its related pathways are Cell junction organization and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium ion binding and proton-dependent oligopeptide secondary active transmembrane transporter activity. An important paralog of this gene is CDH16.

UniProtKB/Swiss-Prot for CDH17 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

Gene Wiki entry for CDH17 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH17 Gene

Genomics for CDH17 Gene

Regulatory Elements for CDH17 Gene

Enhancers for CDH17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G094239 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.8 -24.3 -24340 3.5 PKNOX1 FOXA2 SIN3A ZNF2 GLIS2 GATA2 ZNF207 FOS JUNB TSHZ1 GEM CDH17 LOC105375648
GH08G094188 1.1 ENCODE dbSUPER 17.8 +25.6 25627 6.6 FOXA2 THRB RAD21 RARA CAVIN1 ZNF592 TGIF2 CREB3 NFIL3 CEBPA CDH17 ENSG00000272509 GEM RPL6P23 INTS8 LOC105375647
GH08G094119 1.5 FANTOM5 Ensembl ENCODE 11.2 +97.0 97016 1.4 HDAC1 HDGF PKNOX1 ATF1 CBX3 ARNT BMI1 RAD21 ZBTB40 ZNF143 CDH17 GEM ENSG00000253585 LOC105375647
GH08G094099 1.3 Ensembl ENCODE 10 +116.3 116310 2.8 PKNOX1 FOXA2 ZFP64 YY1 FOS JUNB TBX21 PPARG KAT8 ZNF592 ENSG00000253585 CDH17 GC08M094039
GH08G094272 1.2 Ensembl ENCODE dbSUPER 10.7 -55.1 -55095 0.4 CTCF RBBP5 ZNF2 RAD21 ZFHX2 ZNF366 SCRT2 ZNF143 SMC3 EGR2 CDH17 PIR43511 PIR32209
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDH17 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CDH17 gene promoter:

Genomic Location for CDH17 Gene

Chromosome:
8
Start:
94,127,162 bp from pter
End:
94,217,303 bp from pter
Size:
90,142 bases
Orientation:
Minus strand

Genomic View for CDH17 Gene

Genes around CDH17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH17 Gene

Proteins for CDH17 Gene

  • Protein details for CDH17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12864-CAD17_HUMAN
    Recommended name:
    Cadherin-17
    Protein Accession:
    Q12864
    Secondary Accessions:
    • Q15336
    • Q2M2E0

    Protein attributes for CDH17 Gene

    Size:
    832 amino acids
    Molecular mass:
    92219 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDH17 Gene

Post-translational modifications for CDH17 Gene

  • Glycosylation at Asn149, posLast=184184, posLast=250250, posLast=419419, Asn456, Asn546, posLast=587587, and posLast=722722
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH17 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for CDH17

No data available for DME Specific Peptides for CDH17 Gene

Domains & Families for CDH17 Gene

Gene Families for CDH17 Gene

Protein Domains for CDH17 Gene

Suggested Antigen Peptide Sequences for CDH17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12864

UniProtKB/Swiss-Prot:

CAD17_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH17: view

Function for CDH17 Gene

Molecular function for CDH17 Gene

GENATLAS Biochemistry:
cadherin 17,LI-cadherin,transmembrane glycoprotein component of adherens junction,expressed in the liver and intestine located in a region deleted (LOH) in adult acute leukemia
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

Gene Ontology (GO) - Molecular Function for CDH17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IPI 25336636
GO:0005215 transporter activity TAS 8153632
GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity ISS --
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH17: view

Phenotypes for CDH17 Gene

genes like me logo Genes that share phenotypes with CDH17: view

Animal Models for CDH17 Gene

MGI Knock Outs for CDH17:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CDH17 Gene

Localization for CDH17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH17 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH17 gene
Compartment Confidence
plasma membrane 5
nucleus 5
extracellular 3
cytoskeleton 3
cytosol 3
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for CDH17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane IEA,TAS --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH17: view

Pathways & Interactions for CDH17 Gene

genes like me logo Genes that share pathways with CDH17: view

Gene Ontology (GO) - Biological Process for CDH17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002314 germinal center B cell differentiation IEA --
GO:0002315 marginal zone B cell differentiation IEA --
GO:0006810 transport NAS 8153632
GO:0006857 oligopeptide transport ISS --
GO:0007155 cell adhesion TAS,IEA 8153632
genes like me logo Genes that share ontologies with CDH17: view

No data available for SIGNOR curated interactions for CDH17 Gene

Drugs & Compounds for CDH17 Gene

(2) Drugs for CDH17 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH17: view

Transcripts for CDH17 Gene

Unigene Clusters for CDH17 Gene

Cadherin 17, LI cadherin (liver-intestine):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH17 Gene

No ASD Table

Relevant External Links for CDH17 Gene

GeneLoc Exon Structure for
CDH17
ECgene alternative splicing isoforms for
CDH17

Expression for CDH17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDH17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH17 Gene

This gene is overexpressed in Colon - Transverse (x35.4) and Small Intestine - Terminal Ileum (x15.1).

Protein differential expression in normal tissues from HIPED for CDH17 Gene

This gene is overexpressed in Rectum (22.5), Pancreatic juice (17.0), Colon (14.5), and Fetal gut (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH17 Gene



Protein tissue co-expression partners for CDH17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDH17 Gene:

CDH17

SOURCE GeneReport for Unigene cluster for CDH17 Gene:

Hs.591853

mRNA Expression by UniProt/SwissProt for CDH17 Gene:

Q12864-CAD17_HUMAN
Tissue specificity: Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.

Evidence on tissue expression from TISSUES for CDH17 Gene

  • Intestine(4.5)
  • Nervous system(4.5)
  • Skin(2.6)
  • Heart(2.5)
  • Kidney(2.2)
  • Muscle(2.2)
  • Lymph node(2.1)
  • Pancreas(2.1)
  • Stomach(2.1)
  • Eye(2)
genes like me logo Genes that share expression patterns with CDH17: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH17 Gene

Orthologs for CDH17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH17 34 35
  • 99 (n)
dog
(Canis familiaris)
Mammalia CDH17 34 35
  • 82.99 (n)
cow
(Bos Taurus)
Mammalia CDH17 34 35
  • 82.25 (n)
mouse
(Mus musculus)
Mammalia Cdh17 34 16 35
  • 81.14 (n)
rat
(Rattus norvegicus)
Mammalia Cdh17 34
  • 81.14 (n)
oppossum
(Monodelphis domestica)
Mammalia CDH17 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH17 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH17 34 35
  • 58.39 (n)
lizard
(Anolis carolinensis)
Reptilia CDH17 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh17 34
  • 55.53 (n)
zebrafish
(Danio rerio)
Actinopterygii cdh17 34 35
  • 49.75 (n)
-- 34
Species where no ortholog for CDH17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH17 Gene

ENSEMBL:
Gene Tree for CDH17 (if available)
TreeFam:
Gene Tree for CDH17 (if available)

Paralogs for CDH17 Gene

Paralogs for CDH17 Gene

(9) SIMAP similar genes for CDH17 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDH17: view

Variants for CDH17 Gene

Sequence variations from dbSNP and Humsavar for CDH17 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000034615 -- 94,217,325(+) CCCCT(C/G)CCACT upstream-variant-2KB
rs1000067947 -- 94,175,659(+) TGAAG(A/G)CCTTA intron-variant
rs1000076083 -- 94,128,631(+) ACACT(A/G)TGGAG intron-variant
rs1000128211 -- 94,128,300(+) CCTTT(A/G)TCCTT reference, synonymous-codon
rs1000150846 -- 94,211,514(+) AACCA(G/T)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH17 Gene

Variant ID Type Subtype PubMed ID
dgv465n21 CNV gain 19592680
esv2660000 CNV deletion 23128226
esv3418079 CNV insertion 20981092
esv3618067 CNV gain 21293372
esv3618069 CNV loss 21293372
esv3618070 CNV loss 21293372
esv3618071 CNV loss 21293372
nsv1020665 CNV gain 25217958
nsv1022473 CNV loss 25217958
nsv396169 CNV deletion 16902084
nsv6311 CNV insertion 18451855
nsv831401 CNV loss 17160897

Variation tolerance for CDH17 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH17 Gene

Disorders for CDH17 Gene

MalaCards: The human disease database

(24) MalaCards diseases for CDH17 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • stomach cancer
van maldergem syndrome
  • cerebro-facio-articular syndrome
epithelial predominant wilms' tumor
  • epithelial predominant kidney adenosarcoma
subcorneal pustular dermatosis
  • sneddon-wilkinson disease or syndrome
microcystic meningioma
- elite association - COSMIC cancer census association via MalaCards
Search CDH17 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDH17

Genetic Association Database (GAD)
CDH17
Human Genome Epidemiology (HuGE) Navigator
CDH17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH17
genes like me logo Genes that share disorders with CDH17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH17 Gene

Publications for CDH17 Gene

  1. Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor. (PMID: 19956853) Takamura M. … Aoyagi Y. (Int. J. Oncol. 2010) 3 22 64
  2. Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. (PMID: 19676131) Liu L.X. … Luk J.M. (Hepatology 2009) 3 22 64
  3. A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. (PMID: 19736353) Ising M. … MA1ller-Myhsok B. (Arch. Gen. Psychiatry 2009) 3 46 64
  4. A clinicopathological study on the expression of cadherin-17 and caudal-related homeobox transcription factor (CDX2) in human gastric carcinoma. (PMID: 18353622) Ge J. … Chen Z. (Clin Oncol (R Coll Radiol) 2008) 3 22 64
  5. Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system. (PMID: 18552820) Su M.C. … Jeng Y.M. (Mod. Pathol. 2008) 3 22 64

Products for CDH17 Gene

Sources for CDH17 Gene

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