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CDH17 Gene

protein-coding   GIFtS: 60
GCID: GC08M095208

Cadherin 17, LI Cadherin (Liver-Intestine)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cadherin 17, LI Cadherin (Liver-Intestine)1 2     cadherin-162
Intestinal Peptide-Associated Transporter HPT-12 3     cadherin-172
Liver-Intestine Cadherin2 3     HPT-1 Cadherin2
LI-cadherin2 3     Human Intestinal Peptide-Associated Transporter HPT-12
CDH162 5     Human Peptide Transporter 12
HPT12 5     LI Cadherin2
HPT-12     

External Ids:    HGNC: 17561   Entrez Gene: 10152   Ensembl: ENSG000000791127   OMIM: 6030175   UniProtKB: Q128643   

Export aliases for CDH17 gene to outside databases

Previous GC identifers: GC08M093885 GC08M094985 GC08M094808 GC08M095095 GC08M090347


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDH17 Gene:
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated
glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin
domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of
the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in
the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a
role in the morphological organization of liver and intestine. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jan 2009)

GeneCards Summary for CDH17 Gene:
CDH17 (cadherin 17, LI cadherin (liver-intestine)) is a protein-coding gene. GO annotations related to this gene include proton-dependent oligopeptide secondary active transmembrane transporter activity and calcium ion binding. An important paralog of this gene is CDH16.

UniProtKB/Swiss-Prot: CAD17_HUMAN, Q12864
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell
types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in
intestinal peptide transport

Gene Wiki entry for CDH17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDH17 gene promoter:
         Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDH17 promoter sequence
   Search Chromatin IP Primers for CDH17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDH17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

CDH17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH17 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M095208:  view genomic region     (about GC identifiers)

Start:
95,139,394 bp from pter      End:
95,229,531 bp from pter
Size:
90,138 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAD17_HUMAN, Q12864 (See protein sequence)
Recommended Name: Cadherin-17 precursor  
Size: 832 amino acids; 92219 Da
Secondary accessions: Q15336 Q2M2E0

Explore the universe of human proteins at neXtProt for CDH17: NX_Q12864

Explore proteomics data for CDH17 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn149, Asn184, Asn250, Asn419, Asn456, Asn546, Asn587, Asn722
  • Modification sites at PhosphoSitePlus

  • See CDH17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138135.1  NP_004054.3  

    ENSEMBL proteins: 
     ENSP00000027335   ENSP00000392811   ENSP00000401468   ENSP00000429730   ENSP00000428189  
    Reactome Protein details: Q12864

    CDH17 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MCDH: Cadherins / Major cadherins

    3 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q12864

    ProtoNet protein and cluster: Q12864

    1 Blocks protein domain: IPB002126 Cadherin

    UniProtKB/Swiss-Prot: CAD17_HUMAN, Q12864
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the
    connections, imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 7 cadherin domains


    Find genes that share domains with CDH17           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAD17_HUMAN, Q12864
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
    a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell
    types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in
    intestinal peptide transport

         Genatlas biochemistry entry for CDH17:
    cadherin 17,LI-cadherin,transmembrane glycoprotein component of adherens junction,expressed in the liver and
    intestine located in a region deleted (LOH) in adult acute leukemia

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS8153632
    GO:0005427proton-dependent oligopeptide secondary active transmembrane transporter activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CDH17           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdh17):
     hematopoietic system  immune system 

    Find genes that share phenotypes with CDH17           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdh17tm1Ohn for CDH17

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDH17
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    hsa-miR-3678-3p hsa-miR-548j hsa-miR-607 hsa-miR-548i hsa-miR-1323 hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidCDH17 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH17


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAD17_HUMAN, Q12864: Cell membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus3
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0016323basolateral plasma membrane IEA--

    Find genes that share ontologies with CDH17           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDH17 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    Rho Family GTPases0.61
    ILK Signaling0.49
    2Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    3Non-Canonical Wnt Pathway
    Canonical Wnt Pathway0.53
    4WNT Signaling
    WNT Signaling
    5S-1P Stimulated Signaling
    S-1P Stimulated Signaling


    Find genes that share SuperPaths with CDH17           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDH17 (see all 7)
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    Presenilin-Mediated Signaling

    1 Sino Biological Pathway for CDH17
        Canonical Wnt Pathway

    1 Reactome Pathway for CDH17
        Adherens junctions interactions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDH17
    Interactions:

        GeneGlobe Interaction Network for CDH17

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CDH17 (Q128643 ENSP000000273354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1P352223, ENSP000003444564I2D: score=1 STRING: ENSP00000344456
    ANXA4P095253, ENSP000003778334I2D: score=1 STRING: ENSP00000377833
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport NAS8153632
    GO:0006857oligopeptide transport ----
    GO:0007155cell adhesion TAS8153632
    GO:0007156homophilic cell adhesion IEA--
    GO:0016339calcium-dependent cell-cell adhesion IEA--

    Find genes that share ontologies with CDH17           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDH17 (CAD17)

    1 HMDB Compound for CDH17    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for CDH17 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    valacyclovir 60 1 12821497 (1)



    Find genes that share compounds with CDH17           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDH17 gene (2 alternative transcripts): 
    NM_001144663.1  NM_004063.3  

    Unigene Cluster for CDH17:

    Cadherin 17, LI cadherin (liver-intestine)
    Hs.591853  [show with all ESTs]
    Unigene Representative Sequence: NM_001144663
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000027335(uc003ygh.2 uc011lgo.1 uc011lgp.1) ENST00000441892
    ENST00000450165 ENST00000520952 ENST00000521491
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    hsa-miR-3678-3p hsa-miR-548j hsa-miR-607 hsa-miR-548i hsa-miR-1323 hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-3671
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      QuantiFast Probe-based Assays in human, mouse, rat CDH17

    Additional mRNA sequence: 

    AK130441.1 AK300638.1 AK301001.1 AK312873.1 BC112013.1 BC113464.1 U07969.1 X83228.1 

    3 DOTS entries:

    DT.111667  DT.86855489  DT.95146647 

    Selected AceView cDNA sequences (see all 86):

    BX282194 AA376878 CB129480 AU076801 BX951110 AI732453 NM_004063 CB129071 
    X83228 AI922856 CB130703 U07969 BP383197 BV204413 CB128328 AI623483 
    BX479119 AK130441 BX481723 BF591263 CB163054 BM918123 AW859603 AI262603 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDH17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGAGTGG
    CDH17 Expression
    About this image


    CDH17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Colon (Gastrointestinal Tract)
     
     Pancreas (Endocrine System)
    CDH17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDH17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591853

    UniProtKB/Swiss-Prot: CAD17_HUMAN, Q12864
    Tissue specificity: Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung,
    liver, brain, adrenal gland and skin

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDH17 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdh171 , 5 cadherin 171, 5 81.14(n)1
    79.44(a)1
      4 (5.35 cM)5
    125571  NM_019753.41  NP_062727.11 
     117581475 
    chicken
    (Gallus gallus)
    Aves CDH171 cadherin 17, LI cadherin (liver-intestine) 58.39(n)
    49.63(a)
      420225  NM_001199495.1  NP_001186424.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDH176
    cadherin 17, LI cadherin (liver-intestine)
    49(a)
    1 ↔ 1
    4(18877410-18922494)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdh171 cadherin 17, LI cadherin (liver-intestine) 55.53(n)
    51.2(a)
      100216129  NM_001142108.1  NP_001135580.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF428098.12   -- 76.19(n)   378452  AF428098.1 


    ENSEMBL Gene Tree for CDH17 (if available)
    TreeFam Gene Tree for CDH17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDH17 gene
    CDH162  
    9 SIMAP similar genes for CDH17 using alignment to 4 protein entries:     CAD17_HUMAN (see all proteins):
    CDH11    CDH8    CDH19    CDH16    CDH5    FAT3
    CDH1    CDH22    DSC2

    Find genes that share paralogs with CDH17           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDH17 (see all 1995)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1174879211,2
    Cuntested195140479(+) TCTCAA/C/GAGGTT 4 L V mis11NA 120
    rs575730541,2
    C,F--90404851(+) GATCA-/AAGACCT 2 -- int13Minor allele frequency- AA:0.33NA CSA 6
    rs1504241831,2
    --95138945(+) CAGACC/GCTGTT 2 -- ds50010--------
    rs1836187401,2
    --95139183(+) CTGTTG/TTCTTC 2 -- ds50010--------
    rs763763861,2
    C,F--95139263(+) CTGTCT/CAGGGA 2 -- ds50013Minor allele frequency- C:0.16WA CSA 122
    rs736944001,2
    C,F--95139352(+) TTCTGT/CCCTTC 2 -- ds50012Minor allele frequency- C:0.05WA 120
    rs1453711631,2
    --95139431(+) TTGATC/TTGTCA 2 -- ut310--------
    rs78130341,2
    C,F,A,H--95139664(+) AGCAAC/GATGTC 2 -- ut31 ese37Minor allele frequency- G:0.00NS EA NA 560
    rs1881759891,2
    --95139665(+) GCAACA/GTGTCA 2 -- ut310--------
    rs736944021,2
    C--95139673(+) TCACAT/CTGATT 2 -- ut313Minor allele frequency- C:0.14WA CSA 122

    HapMap Linkage Disequilibrium report for CDH17 (95139394 - 95229531 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CDH17:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660000CNV Deletion23128226
    nsv6311CNV Insertion18451855
    nsv396169CNV Loss16902084
    nsv831401CNV Loss17160897
    dgv465n21CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603017    OMIM disorders: --


    Find genes that share disorders with CDH17           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CDH17 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma gastric 55.6 2 16044349 (1), 15732140 (1)
    gastric carcinoma 55.1 24 18353622 (9), 16044349 (3), 16634965 (1), 11413113 (1) (see all 6)
    gastric cancer 54 17 17063305 (4), 17999183 (3), 16044349 (1), 16253763 (1) (see all 6)
    metaplasia 53.4 6 11413113 (4), 16044349 (1), 15732140 (1)
    hepatocellular carcinoma 46.2 15 19626651 (3), 15701831 (2), 19460698 (2), 19676131 (1) (see all 9)
    metastasis 39.1 16 17063305 (6), 15178443 (3), 15279905 (1), 18353622 (1) (see all 6)
    tumors 30.2 26 15701831 (3), 19626651 (3), 19956853 (2), 17063305 (2) (see all 11)
    adenocarcinoma 29.6 11 18552820 (3), 12824888 (3), 11413113 (1), 15732140 (1)
    carcinoma 19.4 13 18552820 (2), 16044349 (1), 17589897 (1), 12824888 (1) (see all 5)
    cancer 3.96 1 18552820 (1)

    Genetic Association Database (GAD): CDH17
    Human Genome Epidemiology (HuGE) Navigator: CDH17 (1 document)

    Export disorders for CDH17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDH17 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with CDH17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. (PubMed id 19736353)1, 4 Ising M....MA1ller-Myhsok B. (Arch. Gen. Psychiatry 2009)
    2. Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma. (PubMed id 10191097)1, 3 Chalmers I.J....Atkinson M.J. (Genomics 1999)
    3. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. (PubMed id 9615235)1, 3 Kremmidiotis G....Callen D.F. (Genomics 1998)
    4. Association of intestinal peptide transport with a protein related to the cadherin superfamily. (PubMed id 8153632)1, 2 Dantzig A.H.... Skatrud P.L. (Science 1994)
    5. A clinicopathological study on the expression of cadherin-17 and caudal-related homeobox transcription factor (CDX2) in human gastric carcinoma. (PubMed id 18353622)1, 9 Ge J....Chen Z. (Clin Oncol (R Coll Radiol) 2008)
    6. Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor. (PubMed id 19956853)1, 9 Takamura M....Aoyagi Y. (Int. J. Oncol. 2010)
    7. Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system. (PubMed id 18552820)1, 9 Su M.C....Jeng Y.M. (Mod. Pathol. 2008)
    8. Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma. (PubMed id 15279905)1, 9 Takamura M....Aoyagi Y. (Cancer Lett. 2004)
    9. Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas. (PubMed id 12824888)1, 9 Takamura M....Hirohashi S. (Cancer Sci. 2003)
    10. Alternative mRNA splicing of liver intestine-cadherin in hepatocellular carcinoma. (PubMed id 15701831)1, 9 Wang X.Q....Fan S.T. (Clin. Cancer Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1015 HGNC: 1756 AceView: CDH17 Ensembl:ENSG00000079112 euGenes: HUgn1015
    ECgene: CDH17 H-InvDB: CDH17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDH17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDH17 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDH17 gene:
    Search GeneIP for patents involving CDH17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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