Aliases for CDH16 Gene
External Ids for CDH16 Gene
Previous GeneCards Identifiers for CDH16 Gene
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
GeneCards Summary for CDH16 Gene
CDH16 (Cadherin 16) is a Protein Coding gene. Diseases associated with CDH16 include Oxyphilic Adenoma and Renal Oncocytoma. Among its related pathways are TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH17.
UniProtKB/Swiss-Prot for CDH16 Gene
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.