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Aliases for CDH16 Gene

Aliases for CDH16 Gene

  • Cadherin 16 2 3 5
  • Cadherin 16, KSP-Cadherin 2 3
  • Kidney-Specific Cadherin 3 4
  • KSP-Cadherin 3 4
  • Cadherin-16 3

External Ids for CDH16 Gene

Previous GeneCards Identifiers for CDH16 Gene

  • GC16M057636
  • GC16M067319
  • GC16M066677
  • GC16M066718
  • GC16M065499
  • GC16M066942
  • GC16M052816

Summaries for CDH16 Gene

Entrez Gene Summary for CDH16 Gene

  • This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for CDH16 Gene

CDH16 (Cadherin 16) is a Protein Coding gene. Diseases associated with CDH16 include Renal Oncocytoma and Oxyphilic Adenoma. Among its related pathways are Nanog in Mammalian ESC Pluripotency and ERK Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH17.

UniProtKB/Swiss-Prot for CDH16 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Wiki entry for CDH16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH16 Gene

Genomics for CDH16 Gene

Regulatory Elements for CDH16 Gene

Enhancers for CDH16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G066894 1.2 Ensembl ENCODE 18.4 +23.8 23751 0.9 HDGF RB1 ARID4B KLF17 ZNF2 RAD21 RFX5 ZNF121 ZNF143 PCBP1 CES2 CDH16 RRAD FAM96B FBXL8 HSF4 TRADD GC16P066890 PIR47501 GC16P066912
GH16G066977 1.5 Ensembl ENCODE dbSUPER 10.7 -58.8 -58817 0.4 HDGF WRNIP1 ARID4B SIN3A ZNF2 ZNF48 SLC30A9 GLIS2 ZNF143 DEK CES2 ELMO3 CBFB B3GNT9 TRADD FBXL8 HSF4 C16orf70 RRAD CDH16
GH16G066960 1.2 Ensembl ENCODE 11.6 -42.1 -42137 1.0 HDGF PKNOX1 ARNT SIN3A ARID4B ZNF2 ZNF48 ZNF143 DEK MIER2 FBXL8 TRADD HSF4 CES2 RRAD CDH16 FAM96B B3GNT9 CBFB ELMO3
GH16G066879 1.1 ENCODE 12.1 +38.2 38212 2.0 PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF416 CES2 ENSG00000260465 CDH16 RRAD ZDHHC1 FAM96B CENPT CA7 B3GNT9 THAP11
GH16G066895 0.9 ENCODE 12.7 +22.3 22275 1.6 HDAC1 PKNOX1 RAD21 DNMT3B TCF12 CREM CEBPB ZNF398 TGIF2 NFIC CES2 CDH16 RRAD FAM96B FBXL8 TRADD HSF4 GC16P066890 GC16P066910 GC16P066911
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDH16 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CDH16 gene promoter:

Genomic Location for CDH16 Gene

Chromosome:
16
Start:
66,908,122 bp from pter
End:
66,918,984 bp from pter
Size:
10,863 bases
Orientation:
Minus strand

Genomic View for CDH16 Gene

Genes around CDH16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH16 Gene

Proteins for CDH16 Gene

  • Protein details for CDH16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75309-CAD16_HUMAN
    Recommended name:
    Cadherin-16
    Protein Accession:
    O75309
    Secondary Accessions:
    • B4DPA8
    • H3BPD3
    • Q6UW93

    Protein attributes for CDH16 Gene

    Size:
    829 amino acids
    Molecular mass:
    89923 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDH16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH16 Gene

Post-translational modifications for CDH16 Gene

  • Glycosylation at Asn517, Asn602, and Asn722
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDH16 Gene

Domains & Families for CDH16 Gene

Gene Families for CDH16 Gene

Protein Domains for CDH16 Gene

Suggested Antigen Peptide Sequences for CDH16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75309

UniProtKB/Swiss-Prot:

CAD16_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH16: view

Function for CDH16 Gene

Molecular function for CDH16 Gene

GENATLAS Biochemistry:
cadherin 16,Ksp-cadherin,130kDa,transmembrane glycoprotein component of adherens junction,kidney specific,wsith three alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Ontology (GO) - Molecular Function for CDH16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH16: view
genes like me logo Genes that share phenotypes with CDH16: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDH16

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDH16 Gene

Localization for CDH16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH16 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH16 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDH16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with CDH16: view

Pathways & Interactions for CDH16 Gene

genes like me logo Genes that share pathways with CDH16: view

Pathways by source for CDH16 Gene

Gene Ontology (GO) - Biological Process for CDH16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9721215
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007267 cell-cell signaling IBA --
GO:0007399 nervous system development IBA --
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
genes like me logo Genes that share ontologies with CDH16: view

No data available for SIGNOR curated interactions for CDH16 Gene

Drugs & Compounds for CDH16 Gene

(3) Drugs for CDH16 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ispinesib (SB-715992) Pharma Kinesin spindle protein (KSP)inhibitor 0
SB743921 Pharma Potent KSP inhibitor 0
calcium Nutra 0

(2) ApexBio Compounds for CDH16 Gene

Compound Action Cas Number
Ispinesib (SB-715992) Kinesin spindle protein (KSP)inhibitor 336113-53-2
SB743921 Potent KSP inhibitor 940929-33-9
genes like me logo Genes that share compounds with CDH16: view

Transcripts for CDH16 Gene

Unigene Clusters for CDH16 Gene

Cadherin 16, KSP-cadherin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - -
SP2: -
SP3: -
SP4: - - - - - -
SP5: - -
SP6: - - -

ExUns: 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for CDH16 Gene

GeneLoc Exon Structure for
CDH16
ECgene alternative splicing isoforms for
CDH16

Expression for CDH16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDH16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH16 Gene

This gene is overexpressed in Kidney - Cortex (x49.0).

Protein differential expression in normal tissues from HIPED for CDH16 Gene

This gene is overexpressed in Kidney (57.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH16 Gene



Protein tissue co-expression partners for CDH16 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDH16 Gene:

CDH16

SOURCE GeneReport for Unigene cluster for CDH16 Gene:

Hs.513660

mRNA Expression by UniProt/SwissProt for CDH16 Gene:

O75309-CAD16_HUMAN
Tissue specificity: Kidney specific.

Evidence on tissue expression from TISSUES for CDH16 Gene

  • Kidney(4.8)
  • Spleen(4.3)
  • Lung(4)
  • Thyroid gland(3)
genes like me logo Genes that share expression patterns with CDH16: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH16 Gene

Orthologs for CDH16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH16 34 35
  • 98.75 (n)
cow
(Bos Taurus)
Mammalia CDH16 34 35
  • 84.48 (n)
dog
(Canis familiaris)
Mammalia CDH16 34 35
  • 83.35 (n)
mouse
(Mus musculus)
Mammalia Cdh16 34 16 35
  • 80.27 (n)
rat
(Rattus norvegicus)
Mammalia Cdh16 34
  • 80.15 (n)
oppossum
(Monodelphis domestica)
Mammalia CDH16 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH16 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh16 34
  • 47.58 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101886380 34
  • 48.09 (n)
CDH16 35
  • 35 (a)
OneToOne
Species where no ortholog for CDH16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH16 Gene

ENSEMBL:
Gene Tree for CDH16 (if available)
TreeFam:
Gene Tree for CDH16 (if available)

Paralogs for CDH16 Gene

Paralogs for CDH16 Gene

(2) SIMAP similar genes for CDH16 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CDH16: view

Variants for CDH16 Gene

Sequence variations from dbSNP and Humsavar for CDH16 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000184072 -- 66,908,667(+) TCGGC(C/T)GGCTT intron-variant
rs1000890756 -- 66,918,991(+) GCCCC(A/G)CCCAG upstream-variant-2KB
rs1001151236 -- 66,913,918(+) CCCGG(A/G)GTGAC intron-variant
rs1001164287 -- 66,919,164(+) GGCTC(C/T)AGACT upstream-variant-2KB
rs1001479824 -- 66,913,836(+) TGACC(A/G)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH16 Gene

Variant ID Type Subtype PubMed ID
nsv1113815 CNV deletion 24896259
nsv572904 CNV loss 21841781
nsv827706 CNV loss 20364138

Variation tolerance for CDH16 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.09; 75.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH16 Gene

Human Gene Mutation Database (HGMD)
CDH16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH16 Gene

Disorders for CDH16 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CDH16 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal oncocytoma
  • oncocytoma of kidney
oxyphilic adenoma
  • follicular adenoma, oxyphilic cell
chromophobe renal cell carcinoma
  • chromophobe adenocarcinoma
kidney benign neoplasm
  • renal and ureteral tumor
spindle cell carcinoma
  • sarcomatoid carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search CDH16 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDH16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH16
genes like me logo Genes that share disorders with CDH16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH16 Gene

Publications for CDH16 Gene

  1. cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin. (PMID: 9721215) Thomson R.B. … Aronson P.S. (Genomics 1998) 2 3 4 22 64
  2. Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family. (PMID: 7615566) Thomson R.B. … Aronson P.S. (J. Biol. Chem. 1995) 2 3 22 64
  3. alpha B-crystallin is a cytoplasmic interaction partner of the kidney-specific cadherin-16. (PMID: 18343407) Thedieck C. … Klein G. (J. Mol. Biol. 2008) 3 22 64
  4. Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications. (PMID: 17895753) Kuehn A. … Amin M.B. (Am. J. Surg. Pathol. 2007) 3 22 64
  5. Expression of Ksp-cadherin during kidney development and in renal cell carcinoma. (PMID: 15886705) Thedieck C. … Klein G. (Br. J. Cancer 2005) 3 22 64

Products for CDH16 Gene

Sources for CDH16 Gene

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