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Aliases for CDH16 Gene

Aliases for CDH16 Gene

  • Cadherin 16 2 3 5
  • Cadherin 16, KSP-Cadherin 2 3
  • Kidney-Specific Cadherin 3 4
  • KSP-Cadherin 3 4

External Ids for CDH16 Gene

Previous GeneCards Identifiers for CDH16 Gene

  • GC16M057636
  • GC16M067319
  • GC16M066677
  • GC16M066718
  • GC16M065499
  • GC16M066942
  • GC16M052816

Summaries for CDH16 Gene

Entrez Gene Summary for CDH16 Gene

  • This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

GeneCards Summary for CDH16 Gene

CDH16 (Cadherin 16) is a Protein Coding gene. Diseases associated with CDH16 include mucinous tubular and spindle cell carcinoma and tubulocystic carcinoma. Among its related pathways are ERK Signaling and Presenilin-Mediated Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH17.

UniProtKB/Swiss-Prot for CDH16 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Wiki entry for CDH16 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH16 Gene

Genomics for CDH16 Gene

Regulatory Elements for CDH16 Gene

Transcription factor binding sites by QIAGEN in the CDH16 gene promoter:

Genomic Location for CDH16 Gene

Chromosome:
16
Start:
66,908,122 bp from pter
End:
66,918,984 bp from pter
Size:
10,863 bases
Orientation:
Minus strand

Genomic View for CDH16 Gene

Genes around CDH16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH16 Gene

Proteins for CDH16 Gene

  • Protein details for CDH16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75309-CAD16_HUMAN
    Recommended name:
    Cadherin-16
    Protein Accession:
    O75309
    Secondary Accessions:
    • B4DPA8
    • H3BPD3
    • Q6UW93

    Protein attributes for CDH16 Gene

    Size:
    829 amino acids
    Molecular mass:
    89923 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDH16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH16 Gene

Proteomics data for CDH16 Gene at MOPED

Post-translational modifications for CDH16 Gene

  • Glycosylation at Asn 517, Asn 602, and Asn 722
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CDH16 Gene

Domains & Families for CDH16 Gene

Gene Families for CDH16 Gene

Protein Domains for CDH16 Gene

Suggested Antigen Peptide Sequences for CDH16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75309

UniProtKB/Swiss-Prot:

CAD16_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with CDH16: view

Function for CDH16 Gene

Molecular function for CDH16 Gene

GENATLAS Biochemistry:
cadherin 16,Ksp-cadherin,130kDa,transmembrane glycoprotein component of adherens junction,kidney specific,wsith three alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
genes like me logo Genes that share phenotypes with CDH16: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDH16 Gene

Localization for CDH16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH16 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH16 Gene COMPARTMENTS Subcellular localization image for CDH16 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDH16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH16: view

Pathways & Interactions for CDH16 Gene

genes like me logo Genes that share pathways with CDH16: view

Pathways by source for CDH16 Gene

1 Sino Biological pathway for CDH16 Gene

Gene Ontology (GO) - Biological Process for CDH16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with CDH16: view

No data available for SIGNOR curated interactions for CDH16 Gene

Drugs & Compounds for CDH16 Gene

(1) Drugs for CDH16 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH16: view

Transcripts for CDH16 Gene

Unigene Clusters for CDH16 Gene

Cadherin 16, KSP-cadherin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH16 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - -
SP2: -
SP3: -
SP4: - - - - - -
SP5: - -
SP6: - - -

ExUns: 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for CDH16 Gene

GeneLoc Exon Structure for
CDH16
ECgene alternative splicing isoforms for
CDH16

Expression for CDH16 Gene

mRNA expression in normal human tissues for CDH16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH16 Gene

This gene is overexpressed in Kidney - Cortex (x49.0).

Protein differential expression in normal tissues from HIPED for CDH16 Gene

This gene is overexpressed in Kidney (57.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH16 Gene



SOURCE GeneReport for Unigene cluster for CDH16 Gene Hs.513660

mRNA Expression by UniProt/SwissProt for CDH16 Gene

O75309-CAD16_HUMAN
Tissue specificity: Kidney specific.
genes like me logo Genes that share expression patterns with CDH16: view

Protein tissue co-expression partners for CDH16 Gene

Primer Products

In Situ Assay Products

Orthologs for CDH16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDH16 35
  • 84.48 (n)
  • 80.58 (a)
CDH16 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH16 35
  • 83.35 (n)
  • 79.49 (a)
CDH16 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh16 35
  • 80.27 (n)
  • 77.66 (a)
Cdh16 16
Cdh16 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDH16 35
  • 98.75 (n)
  • 98.31 (a)
CDH16 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh16 35
  • 80.15 (n)
  • 77.29 (a)
oppossum
(Monodelphis domestica)
Mammalia CDH16 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH16 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh16 35
  • 47.58 (n)
  • 36.33 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101886380 35
  • 48.09 (n)
  • 36.07 (a)
CDH16 36
  • 35 (a)
OneToOne
Species with no ortholog for CDH16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH16 Gene

ENSEMBL:
Gene Tree for CDH16 (if available)
TreeFam:
Gene Tree for CDH16 (if available)

Paralogs for CDH16 Gene

Paralogs for CDH16 Gene

(2) SIMAP similar genes for CDH16 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CDH16: view

Variants for CDH16 Gene

Sequence variations from dbSNP and Humsavar for CDH16 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2271024 - 66,915,232(+) GCTGA(A/G)GGCCA intron-variant, reference, missense
rs2271023 - 66,914,227(+) CATGT(A/G/T)GTGCG reference, missense
rs34621310 - 66,910,277(+) GGAGG(C/T)GCCAA reference, missense
rs2271025 -- 66,917,880(+) ACAGT(A/G)GCTCT intron-variant
rs3887611 -- 66,920,849(+) GGAAG(A/C/G/T)GGCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDH16 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv827706 CNV Loss 20364138
nsv906791 CNV Loss 21882294
nsv906792 CNV Loss 21882294

Variation tolerance for CDH16 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.09; 75.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH16 Gene

HapMap Linkage Disequilibrium report
CDH16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH16 Gene

Disorders for CDH16 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CDH16 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mucinous tubular and spindle cell carcinoma
tubulocystic carcinoma
kidney cancer
  • renal cell carcinoma
chromophobe adenocarcinoma
  • chromophobe renal cell carcinoma
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CDH16 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDH16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH16
genes like me logo Genes that share disorders with CDH16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH16 Gene

Publications for CDH16 Gene

  1. cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin. (PMID: 9721215) Thomson R.B. … Aronson P.S. (Genomics 1998) 2 3 4 23 67
  2. Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family. (PMID: 7615566) Thomson R.B. … Aronson P.S. (J. Biol. Chem. 1995) 2 3 23
  3. alpha B-crystallin is a cytoplasmic interaction partner of the kidney-specific cadherin-16. (PMID: 18343407) Thedieck C. … Klein G. (J. Mol. Biol. 2008) 3 23
  4. Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications. (PMID: 17895753) Kuehn A. … Amin M.B. (Am. J. Surg. Pathol. 2007) 3 23
  5. Expression of Ksp-cadherin during kidney development and in renal cell carcinoma. (PMID: 15886705) Thedieck C. … Klein G. (Br. J. Cancer 2005) 3 23

Products for CDH16 Gene

Sources for CDH16 Gene

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