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CDH16 Gene

protein-coding   GIFtS: 56
GCID: GC16M066942

Cadherin 16, KSP-Cadherin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cadherin 16, KSP-Cadherin1 2
Kidney-Specific Cadherin2 3
KSP-cadherin2
cadherin-162
Ksp-cadherin3

External Ids:    HGNC: 17551   Entrez Gene: 10142   Ensembl: ENSG000001665897   OMIM: 6031185   UniProtKB: O753093   

Export aliases for CDH16 gene to outside databases

Previous GC identifers: GC16M057636 GC16M067319 GC16M066677 GC16M066718 GC16M065499 GC16M052816


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDH16 Gene:
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated
glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene
localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular
domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the
prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is
exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition,
playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants
encoding distinct isoforms have been identified. (provided by RefSeq, Mar 2011)

GeneCards Summary for CDH16 Gene:
CDH16 (cadherin 16, KSP-cadherin) is a protein-coding gene. Diseases associated with CDH16 include tubulocystic carcinoma, and oxyphilic adenoma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH17.

UniProtKB/Swiss-Prot: CAD16_HUMAN, O75309
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Wiki entry for CDH16 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDH16 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDH16 promoter sequence
   Search Chromatin IP Primers for CDH16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDH16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

CDH16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH16 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M066942:  view genomic region     (about GC identifiers)

Start:
66,942,025 bp from pter      End:
66,952,887 bp from pter
Size:
10,863 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CAD16_HUMAN, O75309 (See protein sequence)
Recommended Name: Cadherin-16 precursor  
Size: 829 amino acids; 89923 Da
Secondary accessions: B4DPA8 H3BPD3 Q6UW93
Alternative splicing: 4 isoforms:  O75309-1   O75309-2   O75309-3   O75309-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDH16: NX_O75309

Explore proteomics data for CDH16 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn517, Asn602, Asn722
  • Modification sites at PhosphoSitePlus

  • See CDH16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001191673.1  NP_001191674.1  NP_001191675.1  NP_004053.1  

    ENSEMBL proteins: 
     ENSP00000377619   ENSP00000299752   ENSP00000455263   ENSP00000456690   ENSP00000454784  
     ENSP00000455523   ENSP00000456891   ENSP00000460891   ENSP00000463451  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MCDH: Cadherins / Major cadherins

    3 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry O75309

    ProtoNet protein and cluster: O75309

    1 Blocks protein domain: IPB002126 Cadherin

    UniProtKB/Swiss-Prot: CAD16_HUMAN, O75309
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the
    connections, imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 6 cadherin domains


    CDH16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAD16_HUMAN, O75309
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
    a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

         Genatlas biochemistry entry for CDH16:
    cadherin 16,Ksp-cadherin,130kDa,transmembrane glycoprotein component of adherens junction,kidney specific,wsith
    three alternatively spliced isoforms

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    CDH16 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDH16:
     Increased cell death HMECs cel  Increased cell death in breast 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDH16
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAD16_HUMAN, O75309: Cell membrane; Single-pass type I membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    CDH16 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDH16 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    Rho Family GTPases0.61
    ILK Signaling0.49
    2Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    3Non-Canonical Wnt Pathway
    Canonical Wnt Pathway0.53
    4WNT Signaling
    WNT Signaling
    5S-1P Stimulated Signaling
    S-1P Stimulated Signaling

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDH16 (see all 7)
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    Presenilin-Mediated Signaling

    1 Sino Biological Pathway for CDH16
        Canonical Wnt Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDH16
    Interactions:

        GeneGlobe Interaction Network for CDH16

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CDH16 (O753093 ENSP000002997524) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1P352223, ENSP000003444564I2D: score=2 STRING: ENSP00000344456
    G6PCENSP000002538014STRING: ENSP00000253801
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS9721215
    GO:0007156homophilic cell adhesion IEA--

    CDH16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDH16 (CAD16)

    1 HMDB Compound for CDH16    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDH16 gene (4 alternative transcripts): 
    NM_001204744.1  NM_001204745.1  NM_001204746.1  NM_004062.3  

    Unigene Cluster for CDH16:

    Cadherin 16, KSP-cadherin
    Hs.513660  [show with all ESTs]
    Unigene Representative Sequence: NM_004062
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394055 ENST00000299752(uc010cdy.3 uc002eql.3 uc021tjx.1 uc002eqm.3)
    ENST00000568632 ENST00000570262 ENST00000565796 ENST00000567269 ENST00000568698
    ENST00000567009 ENST00000565235
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CDH16
      QuantiFast Probe-based Assays in human, mouse, rat CDH16

    Additional mRNA sequence: 

    AF016272.1 AK225544.1 AK298255.1 AK298334.1 AK313101.1 AY358911.1 BC027912.2 

    7 DOTS entries:

    DT.453756  DT.91638378  DT.120681798  DT.100018712  DT.102823716  DT.120681799  DT.120681794 

    Selected AceView cDNA sequences (see all 36):

    CD617915 AK075243 NM_004062 AF016272 CD617923 BI766687 BC027912 AL696168 
    AY358911 BI760840 BG430251 BG054513 BI759247 BX099630 AI733487 AA401704 
    CD617916 AA340453 AI792783 AI791569 BI759833 BI765808 CD617918 CD617910 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDH16 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
    SP1:                                                        -                                                                             -                     
    SP2:                                                                          -                                                                                 
    SP3:                                                        -                                                                                                   
    SP4:                                                  -     -     -     -     -     -                                                                           
    SP5:                          -                             -                                                                                                   

    ExUns: 18a · 18b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CDH16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDH16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGTGCTCC
    CDH16 Expression
    About this image


    CDH16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Kidney (Urinary System)    fully expand to see all 7 entries
             Ureteric Bud Cells Ureteric Bud
             Ureteric Bud
             mK4
             Proximal tubule-like cells
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Sertoli cells Seminiferous Tubules
             Vas Deferens
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Lower Urinary Tract (Urinary System)
             Ureter
    CDH16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDH16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513660

    UniProtKB/Swiss-Prot: CAD16_HUMAN, O75309
    Tissue specificity: Kidney specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDH16 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdh161 , 5 cadherin 161, 5 80.27(n)1
    77.66(a)1
      8 (53.04 cM)5
    125561  NM_007663.31  NP_031689.11 
     1046141415 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdh161 cadherin 16, KSP-cadherin 47.58(n)
    36.33(a)
      100125782  XM_002941993.2  XP_002942039.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018863801 cadherin-16-like 48.09(n)
    36.07(a)
      101886380  XM_005166453.1  XP_005166510.1 


    ENSEMBL Gene Tree for CDH16 (if available)
    TreeFam Gene Tree for CDH16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDH16 gene
    CDH172  
    2 SIMAP similar genes for CDH16 using alignment to 5 protein entries:     CAD16_HUMAN (see all proteins):
    CDH17    DSC2

    CDH16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDH16 (see all 399)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454104991,2
    --66941543(+) CTCACC/TTCACA 4 -- ds50010--------
    rs1140651521,2
    C,F--66941589(+) GGGCCC/TTGCAG 4 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1476691541,2
    C--66941635(+) TGACTC/TATGCA 4 -- ds50010--------
    rs794774341,2
    C,F--66941794(+) CCAGGG/ATCTGT 4 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1919539551,2
    --66941937(+) TTTCTA/CTGTGG 4 -- ds50010--------
    rs1423163711,2
    --66941943(+) TGTGGA/CAGGAG 4 -- ds50010--------
    rs1847891661,2
    --66941966(+) TGAAAA/GAGCAG 4 -- ds50010--------
    rs774631711,2
    C,F--66942206(+) CCTGTC/TCCCTG 4 -- ut312Minor allele frequency- T:0.09WA EA 238
    rs1501918441,2
    C--66942264(+) AGAGGC/TCAAGC 4 -- ut310--------
    rs1386851911,2
    C--66942330(+) TGCTGG/ATTGAT 8 /P /S mis11Minor allele frequency- A:0.00NA 4552

    HapMap Linkage Disequilibrium report for CDH16 (66942025 - 66952887 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CDH16:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv906791CNV Loss21882294
    nsv906792CNV Loss21882294
    dgv2885n71CNV Loss21882294
    nsv827706CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603118    OMIM disorders: --

    15 diseases for CDH16:    
    About MalaCards
    tubulocystic carcinoma    oxyphilic adenoma    mucinous tubular and spindle cell carcinoma    chromophobe renal cell carcinoma
    renal oncocytoma    papillary renal cell carcinoma    nephrogenic adenoma    renal clear cell carcinoma
    spindle cell carcinoma    renal cell carcinoma    wilms tumor    adenoma
    tonsillitis    thyroiditis    leukemia

    3 diseases from the University of Copenhagen DISEASES database for CDH16:
    Renal oncocytoma     Renal cell carcinoma     Oxyphilic adenoma

    CDH16 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for CDH16 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kidney tumor 81.7 3 15696118 (2), 17374232 (1)
    oncocytoma 79.2 11 15712178 (4), 15696118 (2), 16753598 (2), 17374232 (1)
    renal clear cell carcinoma 74.1 4 15712178 (2), 17374232 (1)
    carcinoma renal cell 68.3 19 15712178 (5), 19228645 (2), 15886705 (2), 16753598 (2) (see all 6)
    tumors 27 7 15712178 (2), 17240302 (1), 17374232 (1), 19228645 (1)
    carcinoma 23 4 15712178 (2)


    Export disorders for CDH16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDH16 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with CDH16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin. (PubMed id 9721215)1, 2, 3, 9 Thomson R.B....Aronson P.S. (Genomics 1998)
    2. Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family. (PubMed id 7615566)1, 3, 9 Thomson R.B....Aronson P.S. (J. Biol. Chem. 1995)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Expression of Ksp-cadherin during kidney development and in renal cell carcinoma. (PubMed id 15886705)1, 9 Thedieck C....Klein G. (Br. J. Cancer 2005)
    6. alpha B-crystallin is a cytoplasmic interaction partner of the kidney-specific cadherin-16. (PubMed id 18343407)1, 9 Thedieck C....Klein G. (J. Mol. Biol. 2008)
    7. Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping. (PubMed id 10828602)1, 9 Baudry D. and Jeanpierre C. (Cytogenet. Cell Genet. 2000)
    8. Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications. (PubMed id 17895753)1, 9 Kuehn A....Amin M.B. (Am. J. Surg. Pathol. 2007)
    9. CDH16/Ksp-cadherin is expressed in the developing thyroid gland and is strongly down-regulated in thyroid carcinomas. (PubMed id 22028439)1 CalA- G....Nitsch L. (Endocrinology 2012)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1014 HGNC: 1755 AceView: CDH16 Ensembl:ENSG00000166589 euGenes: HUgn1014
    ECgene: CDH16 H-InvDB: CDH16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDH16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDH16 gene:
    Search GeneIP for patents involving CDH16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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