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GIFtS

CDH15 Gene

protein-coding   GIFtS: 66
GCID: GC16P089238

cadherin 15, type 1, M-cadherin (myotubule)

(Previous names: cadherin 15, M-cadherin (myotubule) )
(Previous symbols: CDH3, CDH14)
 Explore 24 diseases affiliated with
CDH15 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDH15    

Aliases
for CDH15 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cadherin 15, Type 1, M-Cadherin (Myotubule)1 2     Cadherin-143
CDH141 2 3 5     Cadherin-151
CDH31 2 3 5     Cadherin-31
MRD32 5     Muscle-Cadherin1
Cadherin 15, M-Cadherin (Myotubule)1     Cadherin-143
CDHM2     M-Cadherin1
MCAD2     Muscle Cadherin3

External Ids:    HGNC: 17541   Entrez Gene: 10132   Ensembl: ENSG000001299107   OMIM: 1140195   UniProtKB: P552913   
ORGUL members:         
NONCODE:n342498    

Export aliases for CDH15 gene to outside databases

Previous GC identifers: GC16P080558 GC16P090226 GC16P088941 GC16P088982 GC16P087765 GC16P074937


Summaries
for CDH15 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDH15:
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion
glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and
a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated
in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes,
specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: CAD15_HUMAN, P55291
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a
homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation

Gene Wiki entry for CDH15


Genomic Views
for CDH15 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010542.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDH15 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDH15 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDH15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDH15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

CDH15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH15 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P089238:  view genomic region     (about GC identifiers)

Start:
 89,238,163 bp from pter      End:
 89,261,900 bp from pter
Size:
 23,738 bases      Orientation:
 plus strand

Proteins
for CDH15 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CAD15_HUMAN, P55291 (See protein sequence)
Recommended Name: Cadherin-15 precursor  
Size: 814 amino acids; 88916 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein

Explore the universe of human proteins at neXtProt for CDH15: NX_P55291

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55291

    • CDH15 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004924.1  
    ENSEMBL proteins: 
     ENSP00000289746  
    Reactome Protein details: P55291
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CDH15 (M-Cadherin/Cadherin-15)
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDH15

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005901caveola IEA--
    GO:0016021integral to membrane IEA--
    GO:0031594neuromuscular junction IEA--


    CDH15 for ontologies           About GeneDecksing



    CDH15 Antibody Products: 
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    Uscn ELISAs and CLIAs for CDH15

    Protein Domains /
    Families
    for CDH15 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDH15 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry P55291

    ProtoNet protein and cluster: P55291

    2 Blocks protein families:
    IPB000233 Cadherin cytoplasmic region
    IPB002126 Cadherin


    UniProtKB/Swiss-Prot: CAD15_HUMAN, P55291
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections,
    imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 5 cadherin domains


    Function
    for CDH15 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CAD15_HUMAN, P55291
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a
    homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
    M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation

         Genatlas biochemistry entry for CDH15:
    cadherin 15,M-cadherin,transmembrane glycoprotein component of adherens junction,expressed in the myotubule,deleted in
    breast carcinoma (see TSG16H)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDH15
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--


    CDH15 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Cdh15):
     normal 

    CDH15 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDH15 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of p38 alpha/beta MAPK
    		Activation of p38 alpha/beta MAPK1.00
    		CDO in myogenesis0.55
    		Nuclear translocation of p38 MAPK0.94
    		Myogenesis0.55
    2Cell-cell junction organization
    		Cell-cell junction organization1.00
    		Adherens junctions interactions0.51
    		Cell junction organization0.69
    		Cell-Cell communication0.45
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		ILK Signaling0.45
    4Cytoskeleton remodeling Slit-Robo signaling
    		Cell adhesion Cadherin-mediated cell adhesion0.28
    		Cell adhesion_Cadherin-mediated cell adhesion0.28
    5WNT Signaling
    		WNT Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CDH15
        Cell adhesion Cadherin-mediated cell adhesion

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDH15 (see all 7)
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    Presenilin-Mediated Signaling

    1 GeneGo (Thomson Reuters) Pathway for CDH15
        Cell adhesion Cadherin-mediated cell adhesion

    5/9        Reactome Pathways for CDH15 (see all 9)
        Developmental Biology
    Myogenesis
    Nuclear translocation of p38 MAPK
    Activation of p38 alpha/beta MAPK
    Adherens junctions interactions


    1         Kegg Pathway  (Kegg details for CDH15):
        Cell adhesion molecules (CAMs)


    CDH15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CDH15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for CDH15 (P552913 ENSP000002897464) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARVCFO001923, ENSP000002632074I2D: score=4 STRING: ENSP00000263207
    CTNNA1P352213, ENSP000003046694I2D: score=2 STRING: ENSP00000304669
    JUPP149233, ENSP000003111134I2D: score=2 STRING: ENSP00000311113
    CDH9Q9ULB43, ENSP000002310214I2D: score=1 STRING: ENSP00000231021
    CTNNB1P352223, ENSP000003444564I2D: score=2 STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS9545347
    GO:0007156homophilic cell adhesion IEA--
    GO:0034329cell junction assembly TAS--
    GO:0034332adherens junction organization TAS--
    GO:0042692muscle cell differentiation TAS--


    CDH15 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDH15 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDH15

    1 HMDB Compound for CDH15    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about CDH15 / CAD15 

    Transcripts
    for CDH15 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDH15 gene: 
    NM_004933.2  

    Unigene Cluster for CDH15:

    Cadherin 15, type 1, M-cadherin (myotubule)
    Hs.148090  [show with all ESTs]
    Unigene Representative Sequence: NM_004933
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521087 ENST00000524089(uc010cij.1) ENST00000289746(uc002fmt.3)


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    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDH15

    Additional cDNA sequence: 

    AK308596.1 BC008951.2 D83542.1 

    2 DOTS entries:

    DT.405998  DT.100742648 

    24/49 AceView cDNA sequences (see all 49):

    BU739795 BX105447 AW452260 BC008951 NM_004933 BE298937 D83542 BE205820 
    BE299968 BG825507 BF204724 BF305770 BG827030 AI367045 BE019258 AI885214 
    BQ447253 AI285862 BG828960 BM716054 AI571806 BG825695 BF205767 BE299308 

    GeneLoc Exon Structure


    Expression
    for CDH15 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDH15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGGTCACCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDH15 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/28 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 28) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Muscle Satellite PoolForelimb Muscle Satellite CellsSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Muscle Satellite PoolHindlimb Muscle Satellite CellsSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleCervical Muscle Satellite PoolMuscle Satellite CellsSkeletal Muscle
    Skeletal MuscleHyoid Arch MusclesMuscle Satellite CellsSkeletal Muscle
    Skeletal MuscleLumbar Muscle Satellite PoolMuscle Satellite CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Satellite CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Expanded PAX7 cells (Generation of skelet...)

    See CDH15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDH15

    SOURCE GeneReport for Unigene cluster: Hs.148090

    UniProtKB/Swiss-Prot: CAD15_HUMAN, P55291
    Tissue specificity: Expressed in the brain and cerebellum

        SABiosciences Custom PCR Arrays for CDH15
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    In Situ
    Assay Products:     
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    Orthologs
    for CDH15 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CDH15 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia CDH156
    		 --
    		 57(a)
    		 1 ↔ 1
    		 GL343487.1(228248-241650)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.102562 Xenopus laevis transcribed sequence with weak similarity more 74.41(n)    CF289740.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb48f122 Danio rerio m-cadherin mRNA, complete cds 75.18(n)    AY443033.1 


    ENSEMBL Gene Tree for CDH15 (if available)
    TreeFam Gene Tree for CDH15 (if available) 

    Paralogs
    for CDH15 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDH15 gene
    CDH42  CDH182  DSG42  CDH32  CDH102  CDH112  CDH12  CDH62  
    DSC22  CDH82  CDH202  CDH222  DSC12  CDH192  DSG12  CDH72  
    DSG22  CDH92  CDH122  CDH262  DSC32  CDH22  CDH242  CDH52  
    DSG32  
    18/21 SIMAP similar genes for CDH15 using alignment to 1 protein entry:     CAD15_HUMAN(see all similar genes):
    CDH2    CDH4    CDH3    CDH13    CDH1    CDH11
    CDH5    CDH7    CDH8    CDH18    CDH6    CDH12
    CDH10    CDH20    CDH9    CDH24    CDH19    DSC2

    CDH15 for paralogs           About GeneDecksing



    Genomic Variants
    for CDH15 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/647 NCBI SNPs in CDH15 are shown (see all 647)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1214345391,2
    		Cpathogenic89245959(+) ACAAGC/TGTCTC 2 R C mis11Minor allele frequency- T:0.00NA 4546
    rs1214345401,2
    		Cpathogenic89246680(+) AGCCCC/TGGGGC 2 R W mis11Minor allele frequency- T:0.00NA 4266
    rs1214345411,2
    		C,F,pathogenic89249963(+) AAGAGC/TGTTTG 2 A V mis11Minor allele frequency- T:0.00NA 4548
    rs1488340231,2
    		--89236166(+) TCAGGC/GTACCC 1 -- us2k10--------
    rs1172974701,2
    		--89236209(+) GAGAAA/GCTGAG 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1434418171,2
    		--89236213(+) AACTGA/GGGCAC 1 -- us2k10--------
    rs732579841,2
    		C,F,--89236320(+) CCCTCG/TCGGGG 1 -- us2k13Minor allele frequency- T:0.31WA 122
    rs1883891531,2
    		--89236321(+) CCTCGA/CGGGGG 1 -- us2k10--------
    rs728193501,2
    		C,F,--89236329(+) GGGCAC/TCTGCC 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs732579861,2
    		C,F,--89236360(+) CCAGGG/CAGCAC 1 -- us2k13Minor allele frequency- C:0.31WA 122

    HapMap Linkage Disequilibrium report for CDH15 (89238163 - 89261900 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CDH15
         1 Indel: 72694
    Human Gene Mutation Database (HGMD): CDH15

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    Disorders / Diseases
    for CDH15 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDH15 for disorders           About GeneDecksing

    OMIM gene information: 114019   
    OMIM disorders: 612580  
    UniProtKB/Swiss-Prot: CAD15_HUMAN, P55291
  • Note=A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation
    • and dysmorphic facial features. Translocation t(11;16)(q24.2;q24)
  • Defects in CDH15 are the cause of mental retardation autosomal dominant type 3 (MRD3) [MIM:612580]. Mental
    • retardation is characterized by significantly sub-average general intellectual functioning associated with impairments
    in adaptative behavior and manifested during the developmental period

    20/24 diseases for CDH15 (see all 24):    About MalaCards
    mental retardation, autosomal dominant 3    nemaline myopathy    chronic obstructive pulmonary disease    muscle hypertrophy
    squamous cell carcinoma of the head and neck    intellectual disability    squamous cell carcinoma    malignant mesothelioma
    pulmonary disease    myopathy    copd    rhabdomyosarcoma
    hepatocellular carcinoma    ovarian carcinoma    cervical cancer    carcinoma
    cervicitis    colon cancer    breast carcinoma    colorectal cancer

    2 Novoseek disease relationships for CDH15 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 16023338 (1), 19403222 (1)
    cancer 0 1 16864496 (1)

    Human Genome Epidemiology (HuGE) Navigator: CDH15 (2 documents)

    Export disorders for CDH15 gene to outside databases

    Publications
    for CDH15 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDH15 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with CDH15)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. (PubMed id 1427864)1, 3, 9 Kaupmann K....Starzinski-Powitz A. (1992)
    2. Alterations in CDH15 and KIRREL3 in patients with mild to severe intellectual disability. (PubMed id 19012874)1, 2 Bhalla K....Srivastava A.K. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. (PubMed id 9030594)1, 2 Shibata T.... Hirohashi S. (1997)
    5. Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin. (PubMed id 9545347)1, 9 Shimoyama Y....Hirohashi S. (1998)
    6. Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation. (PubMed id 12634428)1, 9 Kang J.-S.... Krauss R.S. (2003)
    7. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. (PubMed id 9615235)1, 9 Kremmidiotis G....Callen D.F. (1998)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
    10. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)

    External Searches for CDH15 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDH15 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1013 HGNC: 1754 AceView: CDH15 Ensembl:ENSG00000129910 euGenes: HUgn1013
    ECgene: CDH15 Kegg: 1013 H-InvDB: CDH15

    Other Databases showing CDH15 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDH15 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDH15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDH15 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CDH15 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDH15 gene:
    Search GeneIP for patents involving CDH15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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