Aliases for CDH13 Gene
External Ids for CDH13 Gene
Previous GeneCards Identifiers for CDH13 Gene
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]
GeneCards Summary for CDH13 Gene
CDH13 (Cadherin 13) is a Protein Coding gene. Diseases associated with CDH13 include amyotrophic lateral sclerosis 20 and atherosclerosis. Among its related pathways are ERK Signaling and Cell junction organization. GO annotations related to this gene include calcium ion binding and cadherin binding. An important paralog of this gene is DSG2.
UniProtKB/Swiss-Prot for CDH13 Gene
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.