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Aliases for CDH13 Gene

Aliases for CDH13 Gene

  • Cadherin 13 2 3
  • T-Cadherin 2 3 4
  • CDHH 3 4 6
  • H-Cadherin (Heart) 2 3
  • Heart Cadherin 3 4
  • T-Cad 3 4
  • P105 3 4
  • Cadherin 13, H-Cadherin (Heart) 3
  • Truncated Cadherin 4
  • Cadherin-13 3
  • H-Cadherin 4

External Ids for CDH13 Gene

Summaries for CDH13 Gene

Entrez Gene Summary for CDH13 Gene

  • This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

GeneCards Summary for CDH13 Gene

CDH13 (Cadherin 13) is a Protein Coding gene. Diseases associated with CDH13 include atherosclerosis. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include calcium ion binding and cadherin binding. An important paralog of this gene is DSG2.

UniProtKB/Swiss-Prot for CDH13 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

Gene Wiki entry for CDH13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH13 Gene

Genomics for CDH13 Gene

Genomic Location for CDH13 Gene

Start:
82,626,794 bp from pter
End:
83,800,640 bp from pter
Size:
1,173,847 bases
Orientation:
Plus strand

Genomic View for CDH13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDH13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH13 Gene

Regulatory Elements for CDH13 Gene

Proteins for CDH13 Gene

  • Protein details for CDH13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55290-CAD13_HUMAN
    Recommended name:
    Cadherin-13
    Protein Accession:
    P55290
    Secondary Accessions:
    • A8W476
    • A8W477
    • B7Z590
    • C9JRI6
    • J3KN62
    • Q6GTW4
    • Q8TBX3

    Protein attributes for CDH13 Gene

    Size:
    713 amino acids
    Molecular mass:
    78287 Da
    Quaternary structure:
    • By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.

    Three dimensional structures from OCA and Proteopedia for CDH13 Gene

    Alternative splice isoforms for CDH13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH13 Gene

Proteomics data for CDH13 Gene at MOPED

Post-translational modifications for CDH13 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn52, Asn86, Thr200, Asn382, Asn500, Asn530, Asn598, Asn638, and Asn671

No data available for DME Specific Peptides for CDH13 Gene

Domains for CDH13 Gene

Gene Families for CDH13 Gene

HGNC:
  • MCDH :Cadherins / Major cadherins

Protein Domains for CDH13 Gene

UniProtKB/Swiss-Prot:

CAD13_HUMAN
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.:
    • P55290
  • Contains 5 cadherin domains.:
    • P55290
genes like me logo Genes that share domains with CDH13: view

Function for CDH13 Gene

Molecular function for CDH13 Gene

GENATLAS Biochemistry: cadherin 13,H-cadherin,transmembrane glycoprotein component of adherens junction,expressed in the heart,deleted in lung carcinoma (see TSG16H),hypermethylated or deleted in ovarian tumors (see TSG16A)
UniProtKB/Swiss-Prot Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

Gene Ontology (GO) - Molecular Function for CDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
GO:0030169 low-density lipoprotein particle binding IDA 16013438
GO:0042803 protein homodimerization activity IEA --
GO:0045296 cadherin binding IDA 10601632
genes like me logo Genes that share ontologies with CDH13: view
genes like me logo Genes that share phenotypes with CDH13: view

Animal Models for CDH13 Gene

MGI Knock Outs for CDH13:

miRNA for CDH13 Gene

miRTarBase miRNAs that target CDH13

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CDH13 Gene

Localization for CDH13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH13 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH13 Gene COMPARTMENTS Subcellular localization image for CDH13 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 3
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16873731
GO:0005737 cytoplasm IDA 10737605
GO:0005886 plasma membrane TAS --
GO:0005901 caveola IDA 9650591
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CDH13: view

Pathways for CDH13 Gene

genes like me logo Genes that share pathways with CDH13: view

Gene Ontology (GO) - Biological Process for CDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IMP 15364621
GO:0001954 positive regulation of cell-matrix adhesion IMP 17573778
GO:0002040 sprouting angiogenesis IDA 16873731
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA 10601632
GO:0007162 negative regulation of cell adhesion IDA 14729458
genes like me logo Genes that share ontologies with CDH13: view

Compounds for CDH13 Gene

(1) HMDB Compounds for CDH13 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(8) Novoseek inferred chemical compound relationships for CDH13 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 67.6 7
retinoic acid 19.6 5
matrigel 6.16 3
paraffin 4.17 1
progesterone 1.58 3
genes like me logo Genes that share compounds with CDH13: view

Transcripts for CDH13 Gene

Unigene Clusters for CDH13 Gene

Cadherin 13, H-cadherin (heart):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH13 Gene

No ASD Table

Relevant External Links for CDH13 Gene

GeneLoc Exon Structure for
CDH13
ECgene alternative splicing isoforms for
CDH13

Expression for CDH13 Gene

mRNA expression in normal human tissues for CDH13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH13 Gene

This gene is overexpressed in Artery - Aorta (8.6) and Artery - Coronary (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDH13 Gene

SOURCE GeneReport for Unigene cluster for CDH13 Gene Hs.654386

mRNA Expression by UniProt/SwissProt for CDH13 Gene

P55290-CAD13_HUMAN
Tissue specificity: Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord.
genes like me logo Genes that share expressions with CDH13: view

Orthologs for CDH13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH13 36
  • 98.73 (n)
  • 98.03 (a)
CDH13 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDH13 36
  • 91.72 (n)
  • 95.76 (a)
CDH13 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH13 36
  • 91.61 (n)
  • 95.99 (a)
CDH13 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh13 36
  • 87.99 (n)
  • 94.58 (a)
Cdh13 16
Cdh13 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDH13 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH13 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh13 36
  • 88.24 (n)
  • 95.02 (a)
chicken
(Gallus gallus)
Aves CDH13 36
  • 73.79 (n)
  • 75.99 (a)
CDH13 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh13 36
  • 69.85 (n)
  • 72.94 (a)
zebrafish
(Danio rerio)
Actinopterygii cdh13 36
  • 64.34 (n)
  • 61.65 (a)
cdh13 37
  • 61 (a)
OneToOne
Species with no ortholog for CDH13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH13 Gene

ENSEMBL:
Gene Tree for CDH13 (if available)
TreeFam:
Gene Tree for CDH13 (if available)

Paralogs for CDH13 Gene

Paralogs for CDH13 Gene

Selected SIMAP similar genes for CDH13 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CDH13: view

Variants for CDH13 Gene

Sequence variations from dbSNP and Humsavar for CDH13 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1457 -- 83,735,222(-) AATGC(A/G)GGGCA intron-variant
rs1461 -- 83,735,262(-) ACAAA(A/G)CCCTC intron-variant
rs2156 -- 82,830,861(-) TCACA(G/T)AGAAG intron-variant
rs3999 -- 83,510,199(-) TTATC(C/T)ACTCG intron-variant
rs153648 -- 83,779,639(+) gtaac(A/G)tagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH13 Gene

Variant ID Type Subtype PubMed ID
nsv907014 CNV Gain 21882294
nsv833305 CNV Gain 17160897
esv275004 CNV Loss 21479260
nsv907022 CNV Loss 21882294
nsv907023 CNV Gain 21882294
nsv517665 CNV Loss 19592680
esv1001951 CNV Loss 20482838
esv275089 CNV Loss 21479260
dgv2926n71 CNV Loss 21882294
esv2751616 CNV Gain 17911159
nsv527828 CNV Loss 19592680
nsv526366 CNV Loss 19592680
nsv907026 CNV Gain 21882294
nsv521310 CNV Loss 19592680
esv260026 OTHER Complex 20981092
esv270453 CNV Insertion 20981092
nsv907027 CNV Gain 21882294
nsv827777 CNV Loss 20364138
esv2714801 CNV Deletion 23290073
esv275275 CNV Gain+Loss 21479260
esv271521 CNV Insertion 20981092
esv272584 CNV Insertion 20981092
nsv907028 CNV Loss 21882294
esv267660 CNV Insertion 20981092
dgv2927n71 CNV Loss 21882294
nsv522570 CNV Loss 19592680
esv2714802 CNV Deletion 23290073
esv2670466 CNV Deletion 23128226
esv22422 CNV Loss 19812545
nsv1903 CNV Loss 18451855
esv275233 CNV Gain+Loss 21479260
nsv1904 CNV Insertion 18451855
nsv907031 CNV Loss 21882294
nsv833306 CNV Loss 17160897
nsv527342 CNV Loss 19592680
esv993231 CNV Loss 20482838
nsv907032 CNV Gain 21882294
nsv907033 CNV Gain 21882294
nsv457583 CNV Loss 19166990
nsv518143 CNV Loss 19592680
nsv522936 CNV Loss 19592680
esv29576 CNV Loss 19812545
nsv907034 CNV Loss 21882294
nsv515825 CNV Loss 19592680
esv2714803 CNV Deletion 23290073
esv2671591 CNV Deletion 23128226
esv2660028 CNV Deletion 23128226
esv2286188 CNV Deletion 18987734
esv2714804 CNV Deletion 23290073
esv2714805 CNV Deletion 23290073
nsv833307 CNV Gain+Loss 17160897
nsv1905 CNV Insertion 18451855
nsv510428 CNV Loss 20534489
esv269371 CNV Insertion 20981092
esv2664269 CNV Deletion 23128226
esv1010099 CNV Insertion 20482838
esv1557614 CNV Insertion 17803354
esv2668528 CNV Deletion 23128226
esv2430420 CNV Deletion 19546169
nsv518084 CNV Loss 19592680
nsv907035 CNV Loss 21882294
dgv168n21 CNV Loss 19592680
nsv524580 CNV Loss 19592680
esv275268 CNV Gain+Loss 21479260
nsv523157 CNV Loss 19592680
nsv515680 CNV Loss 19592680
esv33495 CNV Loss 17666407
nsv457586 CNV Loss 19166990
nsv1906 CNV Loss 18451855
esv271748 CNV Insertion 20981092
esv1369956 CNV Insertion 17803354
esv2675891 CNV Deletion 23128226
esv2523201 CNV Deletion 19546169
esv2112702 CNV Deletion 18987734
esv3135 CNV Deletion 18987735
esv2714808 CNV Deletion 23290073
esv9464 CNV Loss 19470904
esv2677002 CNV Deletion 23128226
esv28755 CNV Loss 19812545
esv1768316 CNV Deletion 17803354
esv32756 CNV Loss 17666407
esv2714809 CNV Deletion 23290073
nsv833308 CNV Loss 17160897
dgv916e1 CNV Complex 17122850
esv2714810 CNV Deletion 23290073
esv2714811 CNV Deletion 23290073
esv1003403 CNV Deletion 20482838
esv1572586 CNV Deletion 17803354
nsv103273 CNV Loss 16902084
dgv511e199 CNV Deletion 23128226
dgv495n67 CNV Loss 20364138
esv2714812 CNV Deletion 23290073
nsv471102 CNV Gain 18288195

Relevant External Links for CDH13 Gene

HapMap Linkage Disequilibrium report
CDH13
Human Gene Mutation Database (HGMD)
CDH13

Disorders for CDH13 Gene

(1) MalaCards Diseases for CDH13 Gene

Search for CDH13 Gene in MalaCards »

(35) Novoseek inferred disease relationships for CDH13 Gene

Disease -log(P) Hits PubMed IDs
nsclc 55.4 21
nsclc stage i 51.6 1
tumors 46.9 69
cancer 46.8 25
cancer lung 46.5 13

Relevant External Links for CDH13

Genetic Association Database (GAD)
CDH13
Human Genome Epidemiology (HuGE) Navigator
CDH13
genes like me logo Genes that share disorders with CDH13: view

No data available for UniProtKB/Swiss-Prot for CDH13 Gene

Publications for CDH13 Gene

  1. H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer. (PMID: 8673923) Lee S.W. (Nat. Med. 1996) 2 3 4 23
  2. Identification of an atypical lipoprotein-binding protein from human aortic smooth muscle as T-cadherin. (PMID: 9468307) Tkachuk V.A. … Resink T.J. (FEBS Lett. 1998) 2 3 4 23
  3. Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. (PMID: 7982033) Tanihara H. … Suzuki S. (Cell Adhes. Commun. 1994) 3 4 23
  4. The H-cadherin (CDH13) gene is inactivated in human lung cancer. (PMID: 9737784) Sato M. … Horii A. (Hum. Genet. 1998) 3 4 23
  5. Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its characteristics as a negative growth regulator of epidermal growth factor in neuroblastoma cells. (PMID: 10737605) Takeuchi T. … Ohtsuki Y. (J. Neurochem. 2000) 3 4 23

Products for CDH13 Gene

Sources for CDH13 Gene

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