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Aliases for CDH13 Gene

Aliases for CDH13 Gene

  • Cadherin 13 2 3 5
  • T-Cadherin 2 3 4
  • H-Cadherin (Heart) 2 3
  • Heart Cadherin 3 4
  • T-Cad 3 4
  • CDHH 3 4
  • P105 3 4
  • Cadherin 13, H-Cadherin (Heart) 3
  • Truncated Cadherin 4
  • Cadherin-13 3
  • H-Cadherin 4

External Ids for CDH13 Gene

Previous GeneCards Identifiers for CDH13 Gene

  • GC16P073743
  • GC16P083625
  • GC16P082399
  • GC16P082440
  • GC16P081218
  • GC16P068413

Summaries for CDH13 Gene

Entrez Gene Summary for CDH13 Gene

  • This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

GeneCards Summary for CDH13 Gene

CDH13 (Cadherin 13) is a Protein Coding gene. Diseases associated with CDH13 include Lung Cancer and Attention Deficit-Hyperactivity Disorder. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Cell junction organization. GO annotations related to this gene include calcium ion binding and cadherin binding. An important paralog of this gene is CDH2.

UniProtKB/Swiss-Prot for CDH13 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

Gene Wiki entry for CDH13 Gene

Additional gene information for CDH13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH13 Gene

Genomics for CDH13 Gene

Regulatory Elements for CDH13 Gene

Enhancers for CDH13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H082698 1.3 FANTOM5 Ensembl ENCODE 17.8 +73.8 73832 3.3 TBP FOXA2 JUN MAX ZNF175 CEBPB EBF1 CEBPG EP300 ZNF354B CDH13 MIR8058 ENSG00000280044
GH16H082651 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +27.9 27864 6.9 PKNOX1 FOXA2 TBL1XR1 BATF RAD21 RARA RFX5 ZNF143 FOS ATF7 CDH13 MIR8058
GH16H082659 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +34.1 34115 2.5 PKNOX1 RUNX3 CDH13 PLCG2 MIR8058
GH16H082626 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.3 +4.8 4772 10.3 CTCF SUZ12 JUN BRCA1 RAD21 POLR2A RUNX3 DEK EZH2 STAT1 CDH13 MIR8058
GH16H082650 0.6 ENCODE dbSUPER 11.3 +24.2 24197 0.2 RUNX3 CDH13 MIR8058
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDH13 on UCSC Golden Path with GeneCards custom track

Promoters for CDH13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088597 706 1401 CTCF SUZ12 POLR2A RAD21 SMARCB1 EZH2

Genomic Locations for CDH13 Gene

Genomic Locations for CDH13 Gene
1,173,847 bases
Plus strand

Genomic View for CDH13 Gene

Genes around CDH13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH13 Gene

Proteins for CDH13 Gene

  • Protein details for CDH13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8W476
    • A8W477
    • B7Z590
    • C9JRI6
    • J3KN62
    • Q6GTW4
    • Q8TBX3

    Protein attributes for CDH13 Gene

    713 amino acids
    Molecular mass:
    78287 Da
    Quaternary structure:
    • By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.

    Three dimensional structures from OCA and Proteopedia for CDH13 Gene

    Alternative splice isoforms for CDH13 Gene


neXtProt entry for CDH13 Gene

Post-translational modifications for CDH13 Gene

  • Glycosylation at Asn52, posLast=8686, posLast=200200, Asn382, Asn500, Asn530, Asn598, Asn638, and Asn671
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDH13 Gene

Domains & Families for CDH13 Gene

Gene Families for CDH13 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CDH13 Gene

Suggested Antigen Peptide Sequences for CDH13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
genes like me logo Genes that share domains with CDH13: view

Function for CDH13 Gene

Molecular function for CDH13 Gene

GENATLAS Biochemistry:
cadherin 13,H-cadherin,transmembrane glycoprotein component of adherens junction,expressed in the heart,deleted in lung carcinoma (see TSG16H),hypermethylated or deleted in ovarian tumors (see TSG16A)
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.

Phenotypes From GWAS Catalog for CDH13 Gene

Gene Ontology (GO) - Molecular Function for CDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0030169 low-density lipoprotein particle binding IDA 16013438
GO:0042803 protein homodimerization activity IEA --
GO:0045296 cadherin binding IDA 10601632
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH13: view
genes like me logo Genes that share phenotypes with CDH13: view

Animal Models for CDH13 Gene

MGI Knock Outs for CDH13:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH13 Gene

Localization for CDH13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH13 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDH13 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 3
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16873731
GO:0005737 cytoplasm IDA 10737605
GO:0005886 plasma membrane TAS --
GO:0005901 caveola IDA 9650591
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CDH13: view

Pathways & Interactions for CDH13 Gene

genes like me logo Genes that share pathways with CDH13: view

Gene Ontology (GO) - Biological Process for CDH13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0001938 positive regulation of endothelial cell proliferation IMP 15364621
GO:0001954 positive regulation of cell-matrix adhesion IMP 17573778
GO:0002040 sprouting angiogenesis IDA 16873731
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with CDH13: view

No data available for SIGNOR curated interactions for CDH13 Gene

Drugs & Compounds for CDH13 Gene

(4) Drugs for CDH13 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
Cadherin Peptide, avian Pharma Role in cell adhesion 0

(5) Additional Compounds for CDH13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CDH13 Gene

Compound Action Cas Number
Cadherin Peptide, avian Role in cell adhesion 127650-08-2
genes like me logo Genes that share compounds with CDH13: view

Drug Products

Transcripts for CDH13 Gene

Unigene Clusters for CDH13 Gene

Cadherin 13, H-cadherin (heart):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH13 Gene

No ASD Table

Relevant External Links for CDH13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDH13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDH13 Gene

mRNA differential expression in normal tissues according to GTEx for CDH13 Gene

This gene is overexpressed in Artery - Aorta (x8.6) and Artery - Coronary (x4.9).

Protein differential expression in normal tissues from HIPED for CDH13 Gene

This gene is overexpressed in Urine (11.9), Uterus (10.1), Heart (8.9), and Cerebrospinal fluid (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH13 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDH13 Gene:


SOURCE GeneReport for Unigene cluster for CDH13 Gene:


mRNA Expression by UniProt/SwissProt for CDH13 Gene:

Tissue specificity: Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord.

Evidence on tissue expression from TISSUES for CDH13 Gene

  • Nervous system(5)
  • Liver(4.3)
  • Bone marrow(4)
  • Heart(2.8)
  • Muscle(2.8)
  • Lung(2.5)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CDH13: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDH13 Gene

Orthologs for CDH13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDH13 33 34
  • 98.73 (n)
(Bos Taurus)
Mammalia CDH13 33 34
  • 91.72 (n)
(Canis familiaris)
Mammalia CDH13 33 34
  • 91.61 (n)
(Rattus norvegicus)
Mammalia Cdh13 33
  • 88.24 (n)
(Mus musculus)
Mammalia Cdh13 33 16 34
  • 87.99 (n)
(Ornithorhynchus anatinus)
Mammalia CDH13 34
  • 84 (a)
(Monodelphis domestica)
Mammalia CDH13 34
  • 83 (a)
(Gallus gallus)
Aves CDH13 33 34
  • 73.79 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh13 33
  • 69.85 (n)
(Danio rerio)
Actinopterygii cdh13 33 34
  • 64.34 (n)
Species where no ortholog for CDH13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH13 Gene

Gene Tree for CDH13 (if available)
Gene Tree for CDH13 (if available)

Paralogs for CDH13 Gene

Paralogs for CDH13 Gene

(12) SIMAP similar genes for CDH13 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CDH13: view

Variants for CDH13 Gene

Sequence variations from dbSNP and Humsavar for CDH13 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs375942071 Likely benign 83,748,258(+) GAGTA(C/G/T)TTGAC intron-variant
rs1048612 Benign 83,783,414(-) GCCCC(C/T)GCCGC reference, synonymous-codon
rs2306907 Benign 83,486,473(-) GCCTA(C/T)CGGGG intron-variant
rs34697339 Benign 83,678,282(-) GAGAC(A/G)TCGGG intron-variant, reference, synonymous-codon
rs35549391 Benign 83,670,814(-) CACAG(C/T)TCCTT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDH13 Gene

Variant ID Type Subtype PubMed ID
esv2761929 CNV loss 21179565
esv2762287 CNV loss 21179565
esv28755 CNV loss 19812545
esv29576 CNV loss 19812545
esv3135 CNV loss 18987735
esv2761928 CNV loss 21179565
esv2760442 CNV loss 21179565
esv2760405 CNV loss 21179565
esv2758664 CNV loss 17122850
esv275275 CNV gain+loss 21479260
esv275268 CNV gain+loss 21479260
esv275233 CNV gain+loss 21479260
esv2751616 CNV gain 17911159
esv275089 CNV loss 21479260
esv275004 CNV loss 21479260
esv2714812 CNV deletion 23290073
esv2714811 CNV deletion 23290073
esv2714810 CNV deletion 23290073
esv2714809 CNV deletion 23290073
esv2714808 CNV deletion 23290073
esv2714805 CNV deletion 23290073
esv2714804 CNV deletion 23290073
esv2714803 CNV deletion 23290073
esv2714802 CNV deletion 23290073
esv2714801 CNV deletion 23290073
esv2677002 CNV deletion 23128226
esv2675891 CNV deletion 23128226
esv2671591 CNV deletion 23128226
esv2670466 CNV deletion 23128226
esv2668528 CNV deletion 23128226
esv2664269 CNV deletion 23128226
esv2660028 CNV deletion 23128226
esv2523201 CNV deletion 19546169
esv2430420 CNV deletion 19546169
esv2286188 CNV deletion 18987734
esv22422 CNV loss 19812545
esv2112702 CNV deletion 18987734
esv1768316 CNV deletion 17803354
esv1572586 CNV deletion 17803354
esv1557614 CNV insertion 17803354
esv1369956 CNV insertion 17803354
esv1010099 CNV insertion 20482838
esv1003403 CNV deletion 20482838
esv1001951 CNV loss 20482838
dgv869e212 CNV loss 25503493
dgv868e212 CNV loss 25503493
dgv867e212 CNV loss 25503493
dgv866e212 CNV loss 25503493
dgv545e214 CNV loss 21293372
dgv5258n54 CNV loss 21841781
dgv5257n54 CNV loss 21841781
dgv5256n54 CNV loss 21841781
dgv5255n54 CNV loss 21841781
dgv5253n54 CNV gain 21841781
dgv511e199 CNV deletion 23128226
dgv495n67 CNV loss 20364138
dgv3055n100 CNV gain 25217958
dgv3054n100 CNV gain 25217958
dgv3053n100 CNV loss 25217958
dgv3052n100 CNV loss 25217958
dgv3051n100 CNV gain 25217958
dgv168n21 CNV loss 19592680
nsv833308 CNV loss 17160897
nsv833307 CNV gain+loss 17160897
nsv833306 CNV loss 17160897
nsv833305 CNV gain 17160897
nsv827777 CNV loss 20364138
nsv573405 CNV gain 21841781
nsv573404 CNV loss 21841781
nsv573401 CNV gain 21841781
nsv573400 CNV loss 21841781
nsv573399 CNV loss 21841781
nsv573398 CNV gain 21841781
nsv573397 CNV loss 21841781
nsv573396 CNV loss 21841781
nsv573395 CNV loss 21841781
nsv573388 CNV loss 21841781
nsv573387 CNV loss 21841781
nsv573386 CNV loss 21841781
nsv573385 CNV loss 21841781
nsv573382 CNV loss 21841781
nsv573381 CNV loss 21841781
nsv573380 CNV loss 21841781
nsv573379 CNV gain 21841781
nsv573371 CNV loss 21841781
nsv573367 CNV gain 21841781
nsv527828 CNV loss 19592680
nsv527342 CNV loss 19592680
nsv526366 CNV loss 19592680
nsv524580 CNV loss 19592680
nsv523157 CNV loss 19592680
nsv522936 CNV loss 19592680
nsv522570 CNV loss 19592680
nsv521310 CNV loss 19592680
nsv518143 CNV loss 19592680
nsv518084 CNV loss 19592680
nsv517665 CNV loss 19592680
nsv515825 CNV loss 19592680
nsv515680 CNV loss 19592680
nsv510428 OTHER sequence alteration 20534489
nsv478536 CNV novel sequence insertion 20440878
nsv471102 CNV gain 18288195
nsv457586 CNV loss 19166990
nsv457583 CNV loss 19166990
nsv1906 CNV deletion 18451855
nsv1905 CNV insertion 18451855
nsv1904 CNV insertion 18451855
nsv1903 CNV deletion 18451855
nsv1142886 CNV tandem duplication 24896259
nsv1127520 CNV deletion 24896259
nsv1109026 CNV deletion 24896259
nsv1070360 CNV deletion 25765185
nsv1066832 CNV loss 25217958
nsv1066140 CNV loss 25217958
nsv1065912 CNV loss 25217958
nsv1065896 CNV gain 25217958
nsv1064977 CNV loss 25217958
nsv1064630 CNV gain 25217958
nsv1064438 CNV gain 25217958
nsv1064158 CNV loss 25217958
nsv1063412 CNV gain 25217958
nsv1063276 CNV loss 25217958
nsv1062520 CNV loss 25217958
nsv1061288 CNV gain+loss 25217958
nsv1061195 CNV gain 25217958
nsv1060245 CNV loss 25217958
nsv1060011 CNV gain 25217958
nsv1059718 CNV loss 25217958
nsv1059489 CNV gain 25217958
nsv1059219 CNV loss 25217958
nsv1057720 CNV gain 25217958
nsv1056158 CNV loss 25217958
nsv1055547 CNV loss 25217958
nsv1055454 CNV loss 25217958
nsv1055277 CNV gain 25217958
nsv103273 CNV deletion 16902084
esv993231 CNV loss 20482838
esv9464 CNV loss 19470904
esv3892923 CNV loss 25118596
esv3892922 CNV loss 25118596
esv3892921 CNV loss 25118596
esv3892920 CNV loss 25118596
esv3892919 CNV loss 25118596
esv3892918 CNV loss 25118596
esv3892917 CNV loss 25118596
esv3892916 CNV loss 25118596
esv3639395 CNV loss 21293372
esv3639394 CNV loss 21293372
esv3639393 CNV loss 21293372
esv3639392 CNV loss 21293372
esv3639391 CNV loss 21293372
esv3639390 CNV loss 21293372
esv3639387 CNV loss 21293372
esv3639386 CNV loss 21293372
esv3639385 CNV loss 21293372
esv3639384 CNV loss 21293372
esv3639382 CNV gain 21293372
esv3639380 CNV loss 21293372
esv3639379 CNV loss 21293372
esv3639372 CNV loss 21293372
esv3639369 CNV loss 21293372
esv3639368 CNV loss 21293372
esv3582413 CNV loss 25503493
esv3582412 CNV loss 25503493
esv3582409 CNV loss 25503493
esv3582408 CNV loss 25503493
esv3582407 CNV loss 25503493
esv3582401 CNV loss 25503493
esv3582400 CNV loss 25503493
esv3582395 CNV loss 25503493
esv3582392 CNV loss 25503493
esv3582391 CNV loss 25503493
esv3553791 CNV deletion 23714750
esv3553786 CNV deletion 23714750
esv3553783 CNV deletion 23714750
esv3553779 CNV deletion 23714750
esv3553778 CNV deletion 23714750
esv3553776 CNV deletion 23714750
esv3553773 CNV deletion 23714750
esv3443683 CNV insertion 20981092
esv3429289 CNV insertion 20981092
esv3405695 CNV insertion 20981092
esv3405118 CNV insertion 20981092
esv3404617 CNV insertion 20981092
esv33495 CNV loss 17666407
esv3334036 CNV insertion 20981092
esv3325357 CNV insertion 20981092
esv3310555 CNV novel sequence insertion 20981092
esv3308310 CNV mobile element insertion 20981092
esv3307245 CNV mobile element insertion 20981092
esv3306176 CNV mobile element insertion 20981092
esv3305093 CNV mobile element insertion 20981092
esv3303381 CNV mobile element insertion 20981092
esv3303052 CNV tandem duplication 20981092
esv32756 CNV loss 17666407

Variation tolerance for CDH13 Gene

Residual Variation Intolerance Score: 47.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH13 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH13 Gene

Disorders for CDH13 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CDH13 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CDH13 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDH13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDH13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH13 Gene

Publications for CDH13 Gene

  1. Identification of an atypical lipoprotein-binding protein from human aortic smooth muscle as T-cadherin. (PMID: 9468307) Tkachuk VA … Resink TJ (FEBS letters 1998) 2 3 4 22 60
  2. H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer. (PMID: 8673923) Lee SW (Nature medicine 1996) 2 3 4 22 60
  3. Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. (PMID: 19304780) Org E … Laan M (Human molecular genetics 2009) 3 22 45 60
  4. Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its characteristics as a negative growth regulator of epidermal growth factor in neuroblastoma cells. (PMID: 10737605) Takeuchi T … Ohtsuki Y (Journal of neurochemistry 2000) 3 4 22 60
  5. The glycosyl phosphatidylinositol anchor of human T-cadherin binds lipoproteins. (PMID: 11027617) Niermann T … Resink T (Biochemical and biophysical research communications 2000) 3 4 22 60

Products for CDH13 Gene

Sources for CDH13 Gene

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