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Aliases for CDH11 Gene

Aliases for CDH11 Gene

  • Cadherin 11, Type 2, OB-Cadherin (Osteoblast) 2 3
  • OB-Cadherin 2 4
  • CAD11 3 6
  • OSF-4 3 4
  • Osteoblast Cadherin 4
  • Cadherin-11 3
  • CDHOB 3
  • OB 3

External Ids for CDH11 Gene

Summaries for CDH11 Gene

Entrez Gene Summary for CDH11 Gene

  • This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH11 Gene

CDH11 (Cadherin 11, Type 2, OB-Cadherin (Osteoblast)) is a Protein Coding gene. Diseases associated with CDH11 include aneurysmal bone cysts and malignant peritoneal mesothelioma. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH19.

UniProtKB/Swiss-Prot for CDH11 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Wiki entry for CDH11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH11 Gene

Genomics for CDH11 Gene

Genomic Location for CDH11 Gene

64,882,891 bp from pter
65,126,112 bp from pter
243,222 bases
Minus strand

Genomic View for CDH11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDH11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH11 Gene

Regulatory Elements for CDH11 Gene

Proteins for CDH11 Gene

  • Protein details for CDH11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K5D6
    • A8MZC8
    • B7WP28
    • Q15065
    • Q15066
    • Q9UQ93
    • Q9UQ94

    Protein attributes for CDH11 Gene

    796 amino acids
    Molecular mass:
    87965 Da
    Quaternary structure:
    • Interacts with PCDH8.

    Alternative splice isoforms for CDH11 Gene


neXtProt entry for CDH11 Gene

Proteomics data for CDH11 Gene at MOPED

Post-translational modifications for CDH11 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn455 and Asn540

Other Protein References for CDH11 Gene

No data available for DME Specific Peptides for CDH11 Gene

Domains for CDH11 Gene

Gene Families for CDH11 Gene

  • MCDH :Cadherins / Major cadherins


  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.:
    • P55287
  • Contains 5 cadherin domains.:
    • P55287
genes like me logo Genes that share domains with CDH11: view

Function for CDH11 Gene

Molecular function for CDH11 Gene

GENATLAS Biochemistry: cadherin 11,OB-cadherin,transmembrane glycoprotein component of adherens junction,expressed in osteoblast
UniProtKB/Swiss-Prot Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Ontology (GO) - Molecular Function for CDH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDH11: view

Phenotypes for CDH11 Gene

MGI mutant phenotypes for CDH11:
inferred from 1 alleles
GenomeRNAi human phenotypes for CDH11:
genes like me logo Genes that share phenotypes with CDH11: view

Animal Models for CDH11 Gene

MGI Knock Outs for CDH11:

miRNA for CDH11 Gene

miRTarBase miRNAs that target CDH11

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CDH11 Gene

Localization for CDH11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH11 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CDH11 Gene COMPARTMENTS Subcellular localization image for CDH11 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2

Gene Ontology (GO) - Cellular Components for CDH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CDH11: view

Pathways for CDH11 Gene

genes like me logo Genes that share pathways with CDH11: view

Pathways by source for CDH11 Gene

1 Cell Signaling Technology pathway for CDH11 Gene

Gene Ontology (GO) - Biological Process for CDH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8163513
GO:0001503 ossification NAS 8163513
GO:0007155 cell adhesion TAS 8163513
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0021957 corticospinal tract morphogenesis IEA --
genes like me logo Genes that share ontologies with CDH11: view

Compounds for CDH11 Gene

(1) HMDB Compounds for CDH11 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(1) Novoseek inferred chemical compound relationships for CDH11 Gene

Compound -log(P) Hits PubMed IDs
progesterone 4.83 6
genes like me logo Genes that share compounds with CDH11: view

Transcripts for CDH11 Gene

Unigene Clusters for CDH11 Gene

Cadherin 11, type 2, OB-cadherin (osteoblast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h · 11i ^ 12a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - -
SP12: - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - -

ExUns: 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP2: -

Relevant External Links for CDH11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDH11 Gene

mRNA expression in normal human tissues for CDH11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDH11 Gene

This gene is overexpressed in Ovary (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDH11 Gene

SOURCE GeneReport for Unigene cluster for CDH11 Gene Hs.116471

mRNA Expression by UniProt/SwissProt for CDH11 Gene

Tissue specificity: Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts
genes like me logo Genes that share expressions with CDH11: view

Orthologs for CDH11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDH11 36
  • 99.62 (n)
  • 99.62 (a)
CDH11 37
  • 100 (a)
(Bos Taurus)
Mammalia CDH11 36
  • 92.88 (n)
  • 98.74 (a)
CDH11 37
  • 99 (a)
(Canis familiaris)
Mammalia CDH11 36
  • 91.88 (n)
  • 98.24 (a)
CDH11 37
  • 98 (a)
(Mus musculus)
Mammalia Cdh11 36
  • 89.91 (n)
  • 97.36 (a)
Cdh11 16
Cdh11 37
  • 97 (a)
(Monodelphis domestica)
Mammalia CDH11 37
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia CDH11 37
  • 88 (a)
(Rattus norvegicus)
Mammalia Cdh11 36
  • 90.24 (n)
  • 98.24 (a)
(Gallus gallus)
Aves CDH11 36
  • 80.05 (n)
  • 90.78 (a)
CDH11 37
  • 91 (a)
(Anolis carolinensis)
Reptilia CDH11 37
  • 87 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16169 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh11 36
  • 75.13 (n)
  • 83.71 (a)
Str.15472 36
(Danio rerio)
Actinopterygii cdh11 36
  • 69.82 (n)
  • 76.26 (a)
cdh11 37
  • 75 (a)
Species with no ortholog for CDH11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH11 Gene

Gene Tree for CDH11 (if available)
Gene Tree for CDH11 (if available)

Paralogs for CDH11 Gene

Paralogs for CDH11 Gene

genes like me logo Genes that share paralogs with CDH11: view

Variants for CDH11 Gene

Sequence variations from dbSNP and Humsavar for CDH11 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs28216 -- 64,988,211(-) GAATC(A/G)TTTGA synonymous-codon, reference
rs35139 -- 64,957,869(+) AGTCA(A/G)TGTTT intron-variant
rs35140 -- 64,956,868(+) GCCCA(A/G)TGAGG intron-variant
rs35141 -- 64,956,764(+) TGTAC(A/C)CTTTT intron-variant
rs35142 -- 64,955,518(+) agaat(C/T)gttta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH11 Gene

Variant ID Type Subtype PubMed ID
nsv833260 CNV Loss 17160897
nsv1831 CNV Loss 18451855
esv34131 CNV Loss 18971310

Relevant External Links for CDH11 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for CDH11 Gene


  • Note=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

(11) Novoseek inferred disease relationships for CDH11 Gene

Disease -log(P) Hits PubMed IDs
osteosarcoma 37.9 10
metastasis 31.3 16
rheumatoid arthritis 24.9 5
choriocarcinoma 24.4 3
carcinoma 22.3 3

Relevant External Links for CDH11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CDH11: view

Publications for CDH11 Gene

  1. Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. (PMID: 8163513) Okazaki M. … Amann E. (J. Biol. Chem. 1994) 3 4 23
  2. Cadherin-11 is expressed in invasive breast cancer cell lines. (PMID: 10029089) Pishvaian M.J. … Byers S.W. (Cancer Res. 1999) 3 23
  3. Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11. (PMID: 10320525) Kawaguchi J. … Kudo A. (J. Bone Miner. Res. 1999) 3 23
  4. Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium. (PMID: 9520111) Getsios S. … MacCalman C.D. (Dev. Dyn. 1998) 3 23
  5. Anomalous cadherin expression in osteosarcoma. Possible relationships to metastasis and morphogenesis. (PMID: 10550312) Kashima T. … Kudo A. (Am. J. Pathol. 1999) 3 23

Products for CDH11 Gene

Sources for CDH11 Gene

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