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CDH11 Gene

protein-coding   GIFtS: 68
GCID: GC16M064977

Cadherin 11, Type 2, OB-Cadherin (Osteoblast)

  See CDH11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cadherin 11, Type 2, OB-Cadherin (Osteoblast)1 2     OB2
OSF-42 3     cadherin-112
CAD112 5     OB-cadherin3
OB-Cadherin1     Osteoblast Cadherin3
CDHOB2     

External Ids:    HGNC: 17501   Entrez Gene: 10092   Ensembl: ENSG000001409377   OMIM: 6000235   UniProtKB: P552873   
ORGUL members:         

Export aliases for CDH11 gene to outside databases

Previous GC identifers: GC16M055361 GC16M065268 GC16M064715 GC16M064755 GC16M063538 GC16M050850


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDH11 Gene:
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that
mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal
extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic
domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence
specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its
upregulation during differentiation, suggests a specific function in bone development and maintenance. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CDH11 Gene:
CDH11 (cadherin 11, type 2, OB-cadherin (osteoblast)) is a protein-coding gene. Diseases associated with CDH11 include aneurysmal bone cysts, and malignant peritoneal mesothelioma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH18.

UniProtKB/Swiss-Prot: CAD11_HUMAN, P55287
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Wiki entry for CDH11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDH11 gene promoter:
         Bach1   C/EBPbeta   Nkx2-2   FOXD3   CUTL1   IRF-1   MEF-2A   Ik-2   Sox9   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDH11 promoter sequence
   Search Chromatin IP Primers for CDH11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDH11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q21

CDH11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH11 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M064977:  view genomic region     (about GC identifiers)

Start:
64,977,656 bp from pter      End:
65,160,015 bp from pter
Size:
182,360 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CAD11_HUMAN, P55287 (See protein sequence)
Recommended Name: Cadherin-11 precursor  
Size: 796 amino acids; 87965 Da
Subunit: Interacts with PCDH8 (By similarity)
Secondary accessions: A8K5D6 A8MZC8 B7WP28 Q15065 Q15066 Q9UQ93 Q9UQ94
Alternative splicing: 2 isoforms:  P55287-1   P55287-2   

Explore the universe of human proteins at neXtProt for CDH11: NX_P55287

Explore proteomics data for CDH11 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn455, Asn540
  • Modification sites at PhosphoSitePlus

  • See CDH11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001788.2  
    ENSEMBL proteins: 
     ENSP00000377711   ENSP00000268603   ENSP00000457812   ENSP00000455779   ENSP00000455420  
     ENSP00000456772   ENSP00000455120   ENSP00000455697   ENSP00000456110  
    Reactome Protein details: P55287

    CDH11 Human Recombinant Protein Products:

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    Novus Biologicals CDH11 Proteins
    Novus Biologicals CDH11 Lysate
    Sino Biological Recombinant Protein for CDH11
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CDH11
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CDH11 

     
    antibodies-online proteins for CDH11 (10 products) 

     
    antibodies-online peptides for CDH11

    CDH11 Antibody Products:

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    antibodies-online antibodies for CDH11 (91 products) 

    CDH11 Assay Products:

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    Search eBioscience for ELISAs for CDH11 
    antibodies-online kits for CDH11 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MCDH: Cadherins / Major cadherins

    5 InterPro protein domains:
     IPR000233 Cadherin_cytoplasmic-dom
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR027397 Catenin_binding_dom
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry P55287

    ProtoNet protein and cluster: P55287

    3 Blocks protein domains:
    IPB000233 Cadherin cytoplasmic region
    IPB001901 Protein secE/sec61-gamma protein
    IPB002126 Cadherin


    UniProtKB/Swiss-Prot: CAD11_HUMAN, P55287
    Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the
    connections, imparting a strong curvature to the full-length ectodomain (By similarity)
    Similarity: Contains 5 cadherin domains


    Find genes that share domains with CDH11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAD11_HUMAN, P55287
    Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in
    a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

         Genatlas biochemistry entry for CDH11:
    cadherin 11,OB-cadherin,transmembrane glycoprotein component of adherens junction,expressed in osteoblast

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with CDH11           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CDH11:
     Cells with protrusions 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cdh11):
     embryogenesis  integument  nervous system 

    Find genes that share phenotypes with CDH11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cdh11tm1Mta for CDH11

       genOway: Develop your customized and physiologically relevant rodent model for CDH11

    miRNA
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    miRTarBase miRNAs that target CDH11:
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    Block miRNA regulation of human, mouse, rat CDH11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDH11 (see all 56):
    hsa-miR-323-3p hsa-miR-4291 hsa-miR-607 hsa-miR-3607-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidCDH11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDH11

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH11

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA6-14316) for CDH11 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAD11_HUMAN, P55287: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CDH11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDH11 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Adherens junctions interactions0.49
    2ERK Signaling
    Rho Family GTPases0.61
    ILK Signaling0.49
    3Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    4Non-Canonical Wnt Pathway
    Canonical Wnt Pathway0.53
    5WNT Signaling
    WNT Signaling


    Find genes that share SuperPaths with CDH11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CDH11 (see all 7)
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    Presenilin-Mediated Signaling

    1 Cell Signaling Technology (CST) Pathway for CDH11
        Adhesion

    1 Sino Biological Pathway for CDH11
        Canonical Wnt Pathway

    1 Reactome Pathway for CDH11
        Adherens junctions interactions


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDH11: 
              Osteogenesis in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDH11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for CDH11 (P552872, 3 ENSP000002686034) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61897 I2D: score=1 
    CDH2P190223, ENSP000002691414I2D: score=3 STRING: ENSP00000269141
    CRKP461083, ENSP000003005744I2D: score=2 STRING: ENSP00000300574
    CTNNB1P352223, ENSP000003444564I2D: score=3 STRING: ENSP00000344456
    CDH10ENSP000002644634STRING: ENSP00000264463
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS8163513
    GO:0001503ossification NAS8163513
    GO:0007155cell adhesion TAS8163513
    GO:0007156homophilic cell adhesion IEA--
    GO:0016337cell-cell adhesion ----

    Find genes that share ontologies with CDH11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDH11 (CAD11)

    1 HMDB Compound for CDH11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for CDH11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 4.83 6 9681502 (3), 10398413 (2), 9520111 (1)



    Find genes that share compounds with CDH11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDH11 gene: 
    NM_001797.2  

    Unigene Cluster for CDH11:

    Cadherin 11, type 2, OB-cadherin (osteoblast)
    Hs.116471  [show with all ESTs]
    Unigene Representative Sequence: D21255
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394156(uc002eoj.3) ENST00000268603(uc010cdn.3 uc002eoi.3 uc010vin.2)
    ENST00000566827 ENST00000569095 ENST00000569128 ENST00000567934(uc010vio.1)
    ENST00000569624 ENST00000562998 ENST00000564317 ENST00000562712 ENST00000562882
    ENST00000562325 ENST00000568340 ENST00000565210 ENST00000563492 ENST00000563255
    ENST00000564770 ENST00000569783
    miRNA
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    hsa-miR-323-3p hsa-miR-4291 hsa-miR-607 hsa-miR-3607-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-16-1*
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    Additional mRNA sequence: 

    AB209760.1 AK291251.1 AK294872.1 AK297377.1 AK308000.1 BC013609.1 D21254.1 D21255.1 
    L34056.1 

    16 DOTS entries:

    DT.216418  DT.100780047  DT.120682746  DT.100839780  DT.120682686  DT.92429692  DT.120682681  DT.120682740 
    DT.120682678  DT.70105040  DT.91667215  DT.100647976  DT.120682691  DT.120682708  DT.120682714  DT.97773761 

    Selected AceView cDNA sequences (see all 197):

    BQ028743 CB216452 AA295671 NM_033664 AW023667 BX100874 CA391193 AI149278 
    AU133055 AW192758 BX337275 AL703198 BI759174 BQ722429 BQ007417 AA247527 
    T27812 AA665539 NM_001797 AA136983 AW630407 AI937810 AI250044 AU280454 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDH11 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h · 11i ^ 12a ·
    SP1:                                                        -     -     -                 -     -                                                               
    SP2:                                                        -     -     -                 -     -                                                               
    SP3:                                                                                      -     -     -     -     -     -     -     -     -     -     -         
    SP4:              -     -     -     -     -     -     -     -     -     -                 -     -                                                               
    SP5:                                                                                            -                                                               

    ExUns: 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                                                              
    SP2:                                                                    -         
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for CDH11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CDH11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGAAAATG
    CDH11 Expression
    About this image


    CDH11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 28) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
             Renal progenitor cells (Metanephric Mesenchyme-like cells)
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Mature Endothelial Cells Blood Brain Barrier
             Midbrain tegmentum
             Oligodendrocyte-like cells
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
             Human umbilical vein endothelial cells (HUVEC)
    CDH11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDH11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.116471

    UniProtKB/Swiss-Prot: CAD11_HUMAN, P55287
    Tissue specificity: Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDH11: 
              Osteogenesis in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Tumor Metastasis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDH11 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdh111 , 5 cadherin 111, 5 89.91(n)1
    97.36(a)1
      8 (50.44 cM)5
    125521  NM_009866.41  NP_033996.41 
     1026329955 
    chicken
    (Gallus gallus)
    Aves CDH111 cadherin 11, type 2, OB-cadherin (osteoblast) 80.05(n)
    90.78(a)
      415797  NM_001004371.1  NP_001004371.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDH116
    cadherin 11, type 2, OB-cadherin (osteoblast)
    87(a)
    1 ↔ 1
    LGc(8454091-8570657)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.161692 Xenopus laevis cadherin precursor (Xcad-11) mRNA, complete more 79.06(n)    AF002983.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdh112 cadherin 11, osteoblast 73.82(n)   30461  U41419.1 


    ENSEMBL Gene Tree for CDH11 (if available)
    TreeFam Gene Tree for CDH11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDH11 gene
    CDH182  CDH222  CDH192  CDH102  CDH72  CDH92  CDH62  CDH122  
    CDH82  CDH242  CDH202  CDH52  
    Selected SIMAP similar genes for CDH11 using alignment to 9 protein entries:     CAD11_HUMAN (see all proteins) (see all similar genes):
    CDH8    CDH9    Nbla04261    CDH6    CDH18    CDH10
    CDH20    CDH7    CDH24    CDH12    CDH22    CDH19
    CDH17    FAT3    DKFZp434K1130    CDH2    CDH5    CDH4

    Find genes that share paralogs with CDH11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDH11 (see all 3430)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348592901,2
    C,F--50850002(+) GCTCAG/CTGTGG 1 -- ds50014Minor allele frequency- C:0.38NA WA 8
    rs349100711,2
    C--50850011(+) TGGGGC/GATAGA 1 -- ds50010--------
    rs1996113081,2
    C--50850011(+) TGGGG-/C/GG  
            
    ATAGA
    1 -- ds50010--------
    rs1453070141,2
    --50850024(+) GTATAA/CCTGGA 1 -- ds50010--------
    rs1471797221,2
    --50850146(+) ACTGAC/GCTAGT 1 -- ds50010--------
    rs1486662701,2
    C--50850350(+) GATCAA/CAATTA 1 -- ds50010--------
    rs1909411371,2
    --50850415(+) GAATCA/CAACCC 1 -- ds50010--------
    rs562153601,2
    C--50850427(+) GAATTA/TAAAAA 1 -- ut310--------
    rs1421869811,2
    C--50850526(+) CGTAAC/TATTTT 1 -- ut310--------
    rs1393272491,2
    C--50850537(+) CTTAC-/ATGTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CDH11 (64977656 - 65160015 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CDH11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833260CNV Loss17160897
    nsv1831CNV Loss18451855
    esv34131CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600023    OMIM disorders: --

    UniProtKB/Swiss-Prot: CAD11_HUMAN, P55287
  • Note=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a
    benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in
    which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional
    up-regulation

  • 2 diseases for CDH11:    
    About MalaCards
    aneurysmal bone cysts    malignant peritoneal mesothelioma


    Find genes that share disorders with CDH11           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CDH11 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteosarcoma 37.9 15 18359978 (5), 10550312 (3), 12569568 (1), 9556063 (1)
    metastasis 31.3 25 18708358 (5), 18359978 (3), 20191612 (2), 10550312 (1) (see all 9)
    rheumatoid arthritis 24.9 7 19404963 (2), 16651616 (1), 15611293 (1), 19274078 (1)
    choriocarcinoma 24.4 3 14675328 (2), 12710956 (1)
    carcinoma 22.3 3 10550312 (1), 19551809 (1), 8616818 (1)
    prostate cancer 22 27 18708358 (5), 20484040 (2), 10910081 (2), 20191612 (2) (see all 6)
    breast cancer 19.4 15 18575746 (4), 12438268 (3), 18193170 (2), 10029089 (2) (see all 5)
    tumors 15.3 29 15383628 (3), 10550312 (2), 18821672 (2), 10029089 (2) (see all 14)
    necrosis 0 4 18821672 (2), 17143626 (1), 17321345 (1)
    gastric cancer 0 3 8616818 (3)

    Genetic Association Database (GAD): CDH11
    Human Genome Epidemiology (HuGE) Navigator: CDH11 (3 documents)

    Export disorders for CDH11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDH11 gene, integrated from 10 sources (see all 137):
    (articles sorted by number of sources associating them with CDH11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. (PubMed id 8163513)1, 2, 9 Okazaki M....Amann E. (J. Biol. Chem. 1994)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (Cancer Res. 2009)
    4. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. (PubMed id 9615235)1, 3 Kremmidiotis G....Callen D.F. (Genomics 1998)
    5. Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. (PubMed id 7982033)1, 2 Tanihara H.... Suzuki S. (Cell Adhes. Commun. 1994)
    6. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PubMed id 2059658)1, 2 Suzuki S.... Tanihara H. (Cell Regul. 1991)
    7. Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation. (PubMed id 18821672)1, 9 Vandooren B....Baeten D. (Arthritis Rheum. 2008)
    8. Cadherin-11 promotes the metastasis of prostate cancer cells to bone. (PubMed id 18708358)1, 9 Chu K....Lin S.H. (Mol. Cancer Res. 2008)
    9. Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone. (PubMed id 18575746)1, 9 Tamura D....Yoneda T. (Int. J. Oncol. 2008)
    10. Minimal 16q genomic loss implicates cadherin-11 in retinoblastoma. (PubMed id 15383628)1, 9 Marchong M.N....Gallie B.L. (Mol. Cancer Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1009 HGNC: 1750 AceView: CDH11 Ensembl:ENSG00000140937 euGenes: HUgn1009
    ECgene: CDH11 H-InvDB: CDH11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDH11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDH11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDH11 gene:
    Search GeneIP for patents involving CDH11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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