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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDH11 Gene

protein-coding GIFtS: 65
GCID: GC16M064977

cadherin 11, type 2, OB-cadherin (osteoblast)

Explore 26 diseases affiliated with
CDH11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cadherin 11, Type 2, OB-Cadherin (Osteoblast)¹ ²		CDHOB²
CAD11¹ ² ⁵		Cadherin-11¹
OB¹ ²		OB-Cadherin¹
OSF-4² ³		Osteoblast Cadherin³

External Ids:	HGNC: 1750¹	Entrez Gene: 1009²	Ensembl: ENSG00000140937⁷	OMIM: 600023⁵	UniProtKB: P55287³

Export aliases for CDH11 gene to outside databases

Previous GC identifers: GC16M055361 GC16M065268 GC16M064715 GC16M064755 GC16M063538 GC16M050850

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDH11:

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate

calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular

domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II

(atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I

cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during

differentiation, suggests a specific function in bone development and maintenance. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CAD11_HUMAN, P55287

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a

homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Wiki entry for CDH11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDH11 gene promoter:
Bach1 C/EBPbeta Nkx2-2 FOXD3 CUTL1 IRF-1 MEF-2A Ik-2 Sox9 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDH11 promoter sequence

Search SABiosciences Chromatin IP Primers for CDH11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDH11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21 Ensembl cytogenetic band: 16q21 HGNC cytogenetic band: 16q21

CDH11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDH11 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M064977: view genomic region (about GC identifiers)

Start:	64,977,656 bp from pter	End:	65,160,015 bp from pter
Size:	182,360 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAD11_HUMAN, P55287 (See protein sequence)

Recommended Name: Cadherin-11 precursor

Size: 796 amino acids; 87965 Da

Subunit: Interacts with PCDH8 (By similarity)

Subcellular location: Cell membrane; Single-pass type I membrane protein

Secondary accessions: A8K5D6 A8MZC8 B7WP28 Q15065 Q15066 Q9UQ93 Q9UQ94

Alternative splicing: 2 isoforms: P55287-1 P55287-2

Explore the universe of human proteins at neXtProt for CDH11: NX_P55287

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P55287

CDH11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001788.2

ENSEMBL proteins:

ENSP00000377711 ENSP00000268603 ENSP00000457812 ENSP00000455779 ENSP00000455420

ENSP00000456772 ENSP00000455120 ENSP00000455697 ENSP00000456110

Reactome Protein details: P55287
Human Recombinant Protein Products for CDH11:

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	Uscn Proteins for CDH11

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	NAS	--

CDH11 for ontologies About GeneDecksing

CDH11 Antibody Products:

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	Uscn ELISAs and CLIAs for CDH11

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDH11 for domains About GeneDecksing

4 InterPro domains/families:

IPR000233 Cadherin_cytoplasmic-dom

IPR015919 Cadherin-like

IPR020894 Cadherin_CS

IPR002126 Cadherin

Graphical View of Domain Structure for InterPro Entry P55287

ProtoNet protein and cluster: P55287

3 Blocks protein families:

IPB000233 Cadherin cytoplasmic region

IPB001901 Protein secE/sec61-gamma protein

IPB002126 Cadherin

UniProtKB/Swiss-Prot: CAD11_HUMAN, P55287

Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections,

imparting a strong curvature to the full-length ectodomain (By similarity)

Similarity: Contains 5 cadherin domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CAD11_HUMAN, P55287

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a

homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Genatlas biochemistry entry for CDH11:

cadherin 11,OB-cadherin,transmembrane glycoprotein component of adherens junction,expressed in osteoblast

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--

CDH11 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CDH11:

Cells with protrusions

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cdh11):

embryogenesis

integument

nervous system

CDH11 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cdh11^tm1Mta for CDH11

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CDH11

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		hsa-miR-323-3p hsa-miR-4291 hsa-miR-607 hsa-miR-3607-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-16-1*

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH11

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell-cell junction organization

	Cell-cell junction organization	1.00			Adherens junctions interactions	0.51
	Cell junction organization	0.69			Cell-Cell communication	0.45

Rho Family GTPases

Rho Family GTPases

1.00

ILK Signaling

0.45

Adhesion

Adhesion

1.00

WNT Signaling

WNT Signaling

1.00

S-1P Stimulated Signaling

S-1P Stimulated Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CDH11 (see all 7)

	S-1P Stimulated Signaling
	ILK Signaling
	GSK3 Signaling
	G12-G13 in Cellular Signaling
	Presenilin-Mediated Signaling

1 Cell Signaling Technology (CST) Pathway for CDH11

Adhesion

4 Reactome Pathways for CDH11

	Adherens junctions interactions
	Cell junction organization
	Cell-Cell communication
	Cell-cell junction organization

CDH11 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDH11

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/18 Interacting proteins for CDH11 (P55287^{2, 3} ENSP00000268603⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATF7IP	Q6VMQ6²^,³	MINT-61897 I2D: score=1
CDH2	P19022³, ENSP00000269141⁴	I2D: score=3 STRING: ENSP00000269141
CRK	P46108³, ENSP00000300574⁴	I2D: score=2 STRING: ENSP00000300574
CTNNB1	P35222³, ENSP00000344456⁴	I2D: score=3 STRING: ENSP00000344456
CDH10	ENSP00000264463⁴	STRING: ENSP00000264463

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	8163513
GO:0001503	ossification	NAS	8163513
GO:0007155	cell adhesion	TAS	8163513
GO:0007156	homophilic cell adhesion	NAS	--
GO:0016337	cell-cell adhesion	NAS	--

CDH11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDH11 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDH11

1 HMDB Compound for CDH11 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 Novoseek chemical compound relationship for CDH11 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
progesterone	4.83	6	9681502 (3), 10398413 (2), 9520111 (1)

Search CenterWatch for drugs/clinical trials and news about CDH11 / CAD11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDH11 gene:

NM_001797.2

Unigene Cluster for CDH11:

Cadherin 11, type 2, OB-cadherin (osteoblast)

Hs.116471 [show with all ESTs]

Unigene Representative Sequence: D21255

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394156(uc002eoj.3) ENST00000268603(uc010cdn.3 uc002eoi.3 uc010vin.2)

ENST00000566827 ENST00000569095 ENST00000569128 ENST00000567934(uc010vio.1)

ENST00000569624 ENST00000562998 ENST00000564317 ENST00000562712 ENST00000562882

ENST00000562325 ENST00000568340 ENST00000565210 ENST00000563492 ENST00000563255

ENST00000564770 ENST00000569783

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDH11
		8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate CDH11 (see all 56):
		hsa-miR-323-3p hsa-miR-4291 hsa-miR-607 hsa-miR-3607-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-128 hsa-miR-16-1*

		SwitchGear 3'UTR luciferase reporter plasmid: CDH11 3' UTR sequence

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Additional cDNA sequence:

AB209760.1 AK291251.1 AK294872.1 AK297377.1 AK308000.1 BC013609.1 D21254.1 D21255.1

L34056.1

16 DOTS entries:

DT.216418 DT.100780047 DT.120682746 DT.100839780 DT.120682686 DT.92429692 DT.120682681 DT.120682740

DT.120682678 DT.70105040 DT.91667215 DT.100647976 DT.120682691 DT.120682708 DT.120682714 DT.97773761

24/197 AceView cDNA sequences (see all 197):

BQ722429 AL703198 AW023667 AI149278 AI937810 AA136983 T27812 AW630407

CB216452 AA378979 BI759174 AU133055 AA295671 AW192758 NM_033664 BX100874

AA247527 NM_001797 AA137109 BQ007417 AU280454 AI573224 BQ028743 AA973217

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for CDH11 (see all 15) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	·	4d	·	4e	·	4f	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c	·	11d	·	11e	·	11f	·	11g	·	11h	·	11i	^	12a	·
SP1:																			-		-		-						-		-
SP2:																			-		-		-						-		-
SP3:																													-		-		-		-		-		-		-		-		-		-		-
SP4:					-		-		-		-		-		-		-		-		-		-						-		-
SP5:																															-

ExUns:	12b	·	12c	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^	22
SP1:
SP2:																							-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CDH11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDH11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGAAAATG

About this image

CDH11 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Tendons & Ligaments

Limb Tendons and Ligamnets

Tenocytes

Tendons & Ligaments

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Kidney

Metanephric Mesenchyme

Metanephric Mesenchyme Cells

Kidney

Kidney

Kidney

Liver

Reproductive System

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/17 LifeMap Cells (see all 17)

Name

Category

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

See CDH11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDH11

SOURCE GeneReport for Unigene cluster: Hs.116471

UniProtKB/Swiss-Prot: CAD11_HUMAN, P55287

Tissue specificity: Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts

SABiosciences Expression via Pathway-Focused PCR Arrays including CDH11:

Osteogenesis in human mouse rat

Polycomb & Trithorax Target Genes in human mouse rat

Tumor Metastasis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDH11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CDH11 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CDH11¹	cadherin 11, type 2, OB-cadherin (osteoblast)	80.05(n) 90.78(a)		415797 NM_001004371.1 NP_001004371.1
lizard (Anolis carolinensis)	Reptilia	CDH11⁶	--	87(a)	1 ↔ 1	LGc(8456500-8508931)
African clawed frog (Xenopus laevis)	Amphibia	Xl.16169²	Xenopus laevis cadherin precursor (Xcad-11) mRNA, complete more	79.06(n)		AF002983.1
zebrafish (Danio rerio)	Actinopterygii	cdh11²	cadherin 11, osteoblast	73.82(n)		30461 U41419.1

ENSEMBL Gene Tree for CDH11 (if available)
TreeFam Gene Tree for CDH11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CDH11 gene

CDH4² CDH18² DSG4² CDH3² CDH10² CDH1² CDH6² DSC2²

CDH8² CDH20² CDH22² DSC1² CDH19² DSG1² CDH7² DSG2²

CDH9² CDH12² CDH26² DSC3² CDH2² CDH24² CDH15² CDH5²

DSG3²

18/24 SIMAP similar genes for CDH11 using alignment to 9 protein entries: CAD11_HUMAN (see all proteins) (see all similar genes):

CDH8 CDH9 Nbla04261 CDH6 CDH18 CDH10

CDH20 CDH7 CDH24 CDH12 CDH22 CDH19

CDH17 FAT3 DKFZp434K1130 CDH2 CDH4 CDH15

CDH11 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79929276^1,2		--	50850588(+)	`AAATTA/GTACAA`	1	--	ut3¹		0	--	--	--	--
rs34181449^1,2	C	--	50851009(+)	`TTTTT-/TCTAGC`	1	--	ut3¹		0	--	--	--	--
rs74026208^1,2	C	--	50852835(+)	`TCATGC/TACCAG`	1	--	int¹		2		WA	120
rs201506666^1,2	C	--	50853070(+)	`TTTTTC/TTTTTT`	1	--	int¹		0	--	--	--	--
rs117646643^1,2	C,F	--	50853857(+)	`AAAAGC/TTTCCA`	1	--	int¹		1		NA	120
rs76947072^1,2	F	--	50853919(+)	`GTGGAG/AGGGTT`	1	--	int¹		1		NA	120
rs76079674^1,2	F	--	50856862(+)	`TGGAAG/AGCCTA`	1	--	int¹		1		WA	118
rs28634089^1,2	F	--	50856883(+)	`TTTTCC/TGTTAG`	1	--	int¹		1		WA	118
rs35651574^1,2	C	--	50856938(+)	`CACACAT/-ATATA`	1	--	int¹		1		NA	2
rs13338009^1,2	C	--	50856940(+)	`acacaC/Tatata`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDH11 (64977656 - 65160015 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CDH11
1 CNV: 47974

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CDH11 for disorders About GeneDecksing

OMIM gene information: 600023 OMIM disorders: --

UniProtKB/Swiss-Prot: CAD11_HUMAN, P55287

Note=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign

osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the

strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation

20/26 diseases for CDH11 (see all 26): About MalaCards

aneurysmal bone cysts malignant peritoneal mesothelioma pleomorphic adenoma inflammatory bowel disease

rheumatoid arthritis renal cell carcinoma choriocarcinoma nephroblastoma

prostate cancer prostate cancer, progression of gastric cancer peritonitis

osteosarcoma arthritis breast cancer adenoma

colon carcinoma ovarian carcinoma prostatitis colon cancer

10/11 Novoseek disease relationships for CDH11 gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
osteosarcoma	37.9	15	18359978 (5), 10550312 (3), 12569568 (1), 9556063 (1)
metastasis	31.3	25	18708358 (5), 18359978 (3), 20191612 (2), 10550312 (1) (see all 9)
rheumatoid arthritis	24.9	7	19404963 (2), 16651616 (1), 15611293 (1), 19274078 (1)
choriocarcinoma	24.4	3	14675328 (2), 12710956 (1)
carcinoma	22.3	3	10550312 (1), 19551809 (1), 8616818 (1)
prostate cancer	22	27	18708358 (5), 20484040 (2), 10910081 (2), 20191612 (2) (see all 6)
breast cancer	19.4	15	18575746 (4), 12438268 (3), 18193170 (2), 10029089 (2) (see all 5)
tumors	15.3	29	15383628 (3), 10550312 (2), 18821672 (2), 10029089 (2) (see all 14)
necrosis	0	4	18821672 (2), 17143626 (1), 17321345 (1)
gastric cancer	0	3	8616818 (3)

Human Genome Epidemiology (HuGE) Navigator: CDH11 (3 documents)

Export disorders for CDH11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CDH11 gene, integrated from 9 sources (see all 129):
(articles sorted by number of sources associating them with CDH11)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. (PubMed id 8163513)^{1, 2, 9} Okazaki M....Amann E. (1994)
Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity. (PubMed id 9615235)^{1, 3} Kremmidiotis G....Callen D.F. (1998)
Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. (PubMed id 7982033)^{1, 2} Tanihara H.... Suzuki S. (1994)
Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. (PubMed id 2059658)^{1, 2} Suzuki S....Tanihara H. (1991)
Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation. (PubMed id 18821672)^{1, 9} Vandooren B....Baeten D. (2008)
Cadherin-11 promotes the metastasis of prostate cancer cells to bone. (PubMed id 18708358)^{1, 9} Chu K....Lin S.H. (2008)
Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone. (PubMed id 18575746)^{1, 9} Tamura D....Yoneda T. (2008)
Minimal 16q genomic loss implicates cadherin-11 in retinoblastoma. (PubMed id 15383628)^{1, 9} Marchong M.N....Gallie B.L. (2004)
CDH11 expression is associated with survival in patients with osteosarcoma. (PubMed id 18359978)^{1, 9} Nakajima G....Ju J. (2008)
Cadherin-11 is expressed in detrusor smooth muscle cells and myofibroblasts of normal human bladder. (PubMed id 17292535)^{1, 9} Kuijpers K.A....Schalken J.A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1009	HGNC: 1750	AceView: CDH11	Ensembl:ENSG00000140937	euGenes: HUgn1009
ECgene: CDH11	H-InvDB: CDH11

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CDH11	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CDH11	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CDH11 gene
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Patent Information for CDH11 gene:
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GeneCards and IP:
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cadherin 11, type 2, OB-cadherin (osteoblast)

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cadherin 11, type 2, OB-cadherin (osteoblast)

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