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Aliases for CDH11 Gene

Aliases for CDH11 Gene

  • Cadherin 11 2 3
  • Cadherin 11, Type 2, OB-Cadherin (Osteoblast) 2 3 5
  • OB-Cadherin 2 4
  • OSF-4 3 4
  • Osteoblast Cadherin 4
  • CAD11 3
  • CDHOB 3
  • OB 3

External Ids for CDH11 Gene

Previous GeneCards Identifiers for CDH11 Gene

  • GC16M055361
  • GC16M065268
  • GC16M064715
  • GC16M064755
  • GC16M063538
  • GC16M064977
  • GC16M050850

Summaries for CDH11 Gene

Entrez Gene Summary for CDH11 Gene

  • This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDH11 Gene

CDH11 (Cadherin 11) is a Protein Coding gene. Diseases associated with CDH11 include aneurysmal bone cysts and malignant peritoneal mesothelioma. Among its related pathways are ERK Signaling and Cell junction organization. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH19.

UniProtKB/Swiss-Prot for CDH11 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Wiki entry for CDH11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH11 Gene

Genomics for CDH11 Gene

Regulatory Elements for CDH11 Gene

Promoters for CDH11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDH11 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDH11 Gene

Chromosome:
16
Start:
64,943,753 bp from pter
End:
65,126,112 bp from pter
Size:
182,360 bases
Orientation:
Minus strand

Genomic View for CDH11 Gene

Genes around CDH11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH11 Gene

Proteins for CDH11 Gene

  • Protein details for CDH11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55287-CAD11_HUMAN
    Recommended name:
    Cadherin-11
    Protein Accession:
    P55287
    Secondary Accessions:
    • A8K5D6
    • A8MZC8
    • B7WP28
    • Q15065
    • Q15066
    • Q9UQ93
    • Q9UQ94

    Protein attributes for CDH11 Gene

    Size:
    796 amino acids
    Molecular mass:
    87965 Da
    Quaternary structure:
    • Interacts with PCDH8.

    Alternative splice isoforms for CDH11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDH11 Gene

Proteomics data for CDH11 Gene at MOPED

Post-translational modifications for CDH11 Gene

  • Glycosylation at Asn 455 and Asn 540
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDH11 (CDH11)

No data available for DME Specific Peptides for CDH11 Gene

Domains & Families for CDH11 Gene

Gene Families for CDH11 Gene

Suggested Antigen Peptide Sequences for CDH11 Gene

Graphical View of Domain Structure for InterPro Entry

P55287

UniProtKB/Swiss-Prot:

CAD11_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH11: view

Function for CDH11 Gene

Molecular function for CDH11 Gene

GENATLAS Biochemistry:
cadherin 11,OB-cadherin,transmembrane glycoprotein component of adherens junction,expressed in osteoblast
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
genes like me logo Genes that share phenotypes with CDH11: view

Animal Models for CDH11 Gene

MGI Knock Outs for CDH11:

Animal Model Products

miRNA for CDH11 Gene

miRTarBase miRNAs that target CDH11

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDH11 Gene

Localization for CDH11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH11 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH11 Gene COMPARTMENTS Subcellular localization image for CDH11 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
endoplasmic reticulum 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CDH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH11: view

Pathways & Interactions for CDH11 Gene

genes like me logo Genes that share pathways with CDH11: view

Pathways by source for CDH11 Gene

Gene Ontology (GO) - Biological Process for CDH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 8163513
GO:0007155 cell adhesion IEA,TAS 8163513
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0034329 cell junction assembly TAS --
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CDH11: view

No data available for SIGNOR curated interactions for CDH11 Gene

Drugs & Compounds for CDH11 Gene

(2) Drugs for CDH11 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH11: view

Transcripts for CDH11 Gene

Unigene Clusters for CDH11 Gene

Cadherin 11, type 2, OB-cadherin (osteoblast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h · 11i ^ 12a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - -
SP12: - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - -
SP15:

ExUns: 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CDH11 Gene

GeneLoc Exon Structure for
CDH11
ECgene alternative splicing isoforms for
CDH11

Expression for CDH11 Gene

mRNA expression in normal human tissues for CDH11 Gene

mRNA differential expression in normal tissues according to GTEx for CDH11 Gene

This gene is overexpressed in Ovary (x6.2).

Protein differential expression in normal tissues from HIPED for CDH11 Gene

This gene is overexpressed in Ovary (9.2), Amniocyte (9.0), and Urine (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CDH11 Gene



SOURCE GeneReport for Unigene cluster for CDH11 Gene Hs.116471

mRNA Expression by UniProt/SwissProt for CDH11 Gene

P55287-CAD11_HUMAN
Tissue specificity: Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts.
genes like me logo Genes that share expression patterns with CDH11: view

Protein tissue co-expression partners for CDH11 Gene

Primer Products

In Situ Assay Products

Orthologs for CDH11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDH11 35
  • 92.88 (n)
  • 98.74 (a)
CDH11 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH11 35
  • 91.88 (n)
  • 98.24 (a)
CDH11 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh11 35
  • 89.91 (n)
  • 97.36 (a)
Cdh11 16
Cdh11 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDH11 35
  • 99.62 (n)
  • 99.62 (a)
CDH11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh11 35
  • 90.24 (n)
  • 98.24 (a)
oppossum
(Monodelphis domestica)
Mammalia CDH11 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH11 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH11 35
  • 80.05 (n)
  • 90.78 (a)
CDH11 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH11 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh11 35
  • 75.13 (n)
  • 83.71 (a)
Str.15472 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16169 35
zebrafish
(Danio rerio)
Actinopterygii cdh11 35
  • 69.82 (n)
  • 76.26 (a)
cdh11 36
  • 75 (a)
OneToOne
Species with no ortholog for CDH11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH11 Gene

ENSEMBL:
Gene Tree for CDH11 (if available)
TreeFam:
Gene Tree for CDH11 (if available)

Paralogs for CDH11 Gene

Paralogs for CDH11 Gene

genes like me logo Genes that share paralogs with CDH11: view

Variants for CDH11 Gene

Sequence variations from dbSNP and Humsavar for CDH11 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs35195 - 64,991,815(+) TGATC(A/G)TCACT reference, missense
rs1130821 - 64,988,331(-) CAGAT(A/C/G)TCTGT reference, missense
rs35213 - 64,982,184(+) TACTG(A/C/T)GATCT reference, missense
rs28216 -- 64,988,211(-) GAATC(A/G)TTTGA reference, synonymous-codon
rs257335 -- 65,023,226(+) CATCT(A/G)TCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH11 Gene

Variant ID Type Subtype PubMed ID
nsv833260 CNV Loss 17160897
nsv1831 CNV Loss 18451855
esv34131 CNV Loss 18971310

Variation tolerance for CDH11 Gene

Residual Variation Intolerance Score: 22.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.47; 96.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH11 Gene

HapMap Linkage Disequilibrium report
CDH11
Human Gene Mutation Database (HGMD)
CDH11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH11 Gene

Disorders for CDH11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CDH11 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
aneurysmal bone cysts
  • bone cysts aneurysmal
malignant peritoneal mesothelioma
  • malignant mesothelioma of peritoneum
osteosarcoma, somatic
  • osteosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search CDH11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CAD11_HUMAN
  • Note=A chromosomal aberration involving CDH11 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with USP6. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.

Relevant External Links for CDH11

Genetic Association Database (GAD)
CDH11
Human Genome Epidemiology (HuGE) Navigator
CDH11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH11
genes like me logo Genes that share disorders with CDH11: view

No data available for Genatlas for CDH11 Gene

Publications for CDH11 Gene

  1. Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. (PMID: 8163513) Okazaki M. … Amann E. (J. Biol. Chem. 1994) 3 4 23 67
  2. MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1. (PMID: 19996288) Sachdeva M. … Mo Y.Y. (Cancer Res. 2010) 3 23
  3. Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells. (PMID: 19274078) Farina A.K. … Byers S.W. (PLoS ONE 2009) 3 23
  4. Alterations in Cx43 and OB-cadherin affect breast cancer cell metastatic potential. (PMID: 18193170) Li Z. … Donahue H.J. (Clin. Exp. Metastasis 2008) 3 23
  5. CDH11 expression is associated with survival in patients with osteosarcoma. (PMID: 18359978) Nakajima G. … Ju J. (Cancer Genomics Proteomics 2008) 3 23

Products for CDH11 Gene

Sources for CDH11 Gene

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