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Aliases for CDH10 Gene

Aliases for CDH10 Gene

  • Cadherin 10, Type 2 (T2-Cadherin) 2 3
  • T2-Cadherin 3 4
  • Cadherin 10 Type 2 3

External Ids for CDH10 Gene

Previous GeneCards Identifiers for CDH10 Gene

  • GC05M024168
  • GC05M024923
  • GC05M024486
  • GC05M024532

Summaries for CDH10 Gene

Entrez Gene Summary for CDH10 Gene

  • This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for CDH10 Gene

CDH10 (Cadherin 10, Type 2 (T2-Cadherin)) is a Protein Coding gene. Diseases associated with CDH10 include lung squamous cell carcinoma. Among its related pathways are ERK Signaling and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH19.

UniProtKB/Swiss-Prot for CDH10 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Wiki entry for CDH10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH10 Gene

Genomics for CDH10 Gene

Regulatory Elements for CDH10 Gene

Genomic Location for CDH10 Gene

Chromosome:
5
Start:
24,487,100 bp from pter
End:
24,645,024 bp from pter
Size:
157,925 bases
Orientation:
Minus strand

Genomic View for CDH10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH10 Gene

Proteins for CDH10 Gene

  • Protein details for CDH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6N8-CAD10_HUMAN
    Recommended name:
    Cadherin-10
    Protein Accession:
    Q9Y6N8
    Secondary Accessions:
    • Q9ULB3

    Protein attributes for CDH10 Gene

    Size:
    788 amino acids
    Molecular mass:
    88451 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDH10 Gene

Proteomics data for CDH10 Gene at MOPED

Post-translational modifications for CDH10 Gene

  • Glycosylation at Asn 256, Asn 438, Asn 456, and Asn 534
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CDH10 Gene

Domains & Families for CDH10 Gene

Gene Families for CDH10 Gene

Suggested Antigen Peptide Sequences for CDH10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6N8

UniProtKB/Swiss-Prot:

CAD10_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH10: view

Function for CDH10 Gene

Molecular function for CDH10 Gene

GENATLAS Biochemistry:
cadherin 10,T2 cadherin,transmembrane glycoprotein,component of adherens junction,predominantly expressed in brain,putatively involved in synaptic adhesions,axon outgrowth and guidance,also expressed in kidney,prostate,fetal lung
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types

Gene Ontology (GO) - Molecular Function for CDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CDH10: view

Phenotypes for CDH10 Gene

GenomeRNAi human phenotypes for CDH10:
genes like me logo Genes that share phenotypes with CDH10: view

Animal Model Products

miRNA for CDH10 Gene

miRTarBase miRNAs that target CDH10

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CDH10 Gene

Localization for CDH10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH10 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH10 Gene COMPARTMENTS Subcellular localization image for CDH10 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH10: view

Pathways & Interactions for CDH10 Gene

genes like me logo Genes that share pathways with CDH10: view

Gene Ontology (GO) - Biological Process for CDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0016337 single organismal cell-cell adhesion NAS 10861224
GO:0034329 cell junction assembly TAS --
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CDH10: view

No data available for SIGNOR curated interactions for CDH10 Gene

Drugs & Compounds for CDH10 Gene

(1) Drugs for CDH10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with CDH10: view

Transcripts for CDH10 Gene

Unigene Clusters for CDH10 Gene

Cadherin 10, type 2 (T2-cadherin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDH10 Gene

No ASD Table

Relevant External Links for CDH10 Gene

GeneLoc Exon Structure for
CDH10
ECgene alternative splicing isoforms for
CDH10

Expression for CDH10 Gene

mRNA expression in normal human tissues for CDH10 Gene

mRNA differential expression in normal tissues according to GTEx for CDH10 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.5), Brain - Frontal Cortex (BA9) (x7.4), Brain - Anterior cingulate cortex (BA24) (x6.9), Brain - Cerebellum (x6.7), and Brain - Cortex (x5.4).

Protein differential expression in normal tissues from HIPED for CDH10 Gene

This gene is overexpressed in Frontal cortex (39.2) and Fetal Brain (25.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDH10 Gene



SOURCE GeneReport for Unigene cluster for CDH10 Gene Hs.92489

mRNA Expression by UniProt/SwissProt for CDH10 Gene

Q9Y6N8-CAD10_HUMAN
Tissue specificity: Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung.
genes like me logo Genes that share expression patterns with CDH10: view

Protein tissue co-expression partners for CDH10 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CDH10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDH10 35
  • 91.62 (n)
  • 98.22 (a)
CDH10 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDH10 35
  • 90.36 (n)
  • 97.21 (a)
CDH10 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdh10 35
  • 88.11 (n)
  • 96.83 (a)
Cdh10 16
Cdh10 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDH10 35
  • 99.87 (n)
  • 100 (a)
CDH10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdh10 35
  • 87.48 (n)
  • 96.32 (a)
oppossum
(Monodelphis domestica)
Mammalia CDH10 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH10 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDH10 35
  • 83.29 (n)
  • 92.77 (a)
CDH10 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDH10 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh10 35
  • 75.1 (n)
  • 83.74 (a)
zebrafish
(Danio rerio)
Actinopterygii cdh10 35
  • 65.09 (n)
  • 65.04 (a)
CABZ01067945.1 36
  • 67 (a)
ManyToMany
cdh10 36
  • 65 (a)
ManyToMany
cdh6 36
  • 61 (a)
ManyToMany
Species with no ortholog for CDH10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH10 Gene

ENSEMBL:
Gene Tree for CDH10 (if available)
TreeFam:
Gene Tree for CDH10 (if available)

Paralogs for CDH10 Gene

Paralogs for CDH10 Gene

(20) SIMAP similar genes for CDH10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDH10: view

Variants for CDH10 Gene

Sequence variations from dbSNP and Humsavar for CDH10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_028751 -
VAR_036102 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for CDH10 Gene

Variant ID Type Subtype PubMed ID
nsv7369 OTHER Inversion 18451855
nsv830236 CNV Loss 17160897
nsv881402 CNV Loss 21882294
nsv881153 CNV Loss 21882294
dgv5980n71 CNV Loss 21882294
dgv5981n71 CNV Loss 21882294
nsv880950 CNV Loss 21882294
dgv5982n71 CNV Loss 21882294
dgv1786e1 CNV Complex 17122850
esv2657466 CNV Deletion 23128226
esv1416666 CNV Insertion 17803354
esv2670513 CNV Deletion 23128226
esv25919 CNV Loss 19812545
nsv512848 CNV Insertion 21212237
nsv880271 CNV Loss 21882294
dgv5983n71 CNV Loss 21882294
nsv4765 CNV Insertion 18451855

Variation tolerance for CDH10 Gene

Residual Variation Intolerance Score: 3.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH10 Gene

HapMap Linkage Disequilibrium report
CDH10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH10 Gene

Disorders for CDH10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDH10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association
Search CDH10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDH10

Genetic Association Database (GAD)
CDH10
Human Genome Epidemiology (HuGE) Navigator
CDH10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH10
genes like me logo Genes that share disorders with CDH10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH10 Gene

Publications for CDH10 Gene

  1. Common genetic variants on 5p14.1 associate with autism spectrum disorders. (PMID: 19404256) Wang K. … Hakonarson H. (Nature 2009) 23 67
  2. The intercellular adhesion molecule, cadherin-10, is a marker for human prostate luminal epithelial cells that is not expressed in prostate cancer. (PMID: 18084254) Walker M.M. … Clark P. (Mod. Pathol. 2008) 23 67
  3. Gene panel model predictive of outcome in men at high-risk of systemic progression and death from prostate cancer after radical retropubic prostatectomy. (PMID: 18711181) Cheville J.C. … Vasmatzis G. (J. Clin. Oncol. 2008) 23 67
  4. Cadherin-10 is a novel blood-brain barrier adhesion molecule in human and mouse. (PMID: 16181616) Williams M.J. … Clark P. (Brain Res. 2005) 23 67
  5. Multiple cadherin mRNA expression and developmental regulation of a novel cadherin in the developing mouse eye. (PMID: 10328938) Faulkner-Jones B.E. … Tan S.S. (Exp. Neurol. 1999) 23 67

Products for CDH10 Gene

Sources for CDH10 Gene

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