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Aliases for CDH10 Gene

Aliases for CDH10 Gene

  • Cadherin 10 2 3 5
  • T2-Cadherin 3 4
  • Cadherin 10, Type 2 (T2-Cadherin) 2
  • Cadherin 10 Type 2 3
  • Cadherin-10 3

External Ids for CDH10 Gene

Previous GeneCards Identifiers for CDH10 Gene

  • GC05M024168
  • GC05M024923
  • GC05M024486
  • GC05M024532

Summaries for CDH10 Gene

Entrez Gene Summary for CDH10 Gene

  • This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for CDH10 Gene

CDH10 (Cadherin 10) is a Protein Coding gene. Diseases associated with CDH10 include Lung Squamous Cell Carcinoma. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Cell junction organization. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CDH6.

UniProtKB/Swiss-Prot for CDH10 Gene

  • Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Wiki entry for CDH10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDH10 Gene

Genomics for CDH10 Gene

Regulatory Elements for CDH10 Gene

Enhancers for CDH10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F024614 0.3 FANTOM5 12.2 +30.3 30268 0.4 CDH10 GC05M024643 GC05P024585
GH05F024644 0.5 ENCODE 11.2 +0.0 48 0.8 TEAD4 ZNF384 ETS1 POLR2A BCL11A SMARCA4 POU5F1 FOXP2 PRDM1 CDH10 GC05M024643
GH05F024567 0.3 FANTOM5 10.9 +78.0 78010 0.0 FOS CDH10 ENSG00000249562 ENSG00000251294
GH05F024595 0.3 FANTOM5 4.9 +49.4 49447 0.4 SUPT20H ENSG00000251294 CDH10 GC05P024585 GC05M024643
GH05F024579 0.3 FANTOM5 1.9 +65.7 65724 0.3 ENSG00000251294 CDH10 ENSG00000249562 GC05P024585
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CDH10 on UCSC Golden Path with GeneCards custom track

Promoters for CDH10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001276923 23 799 TEAD4 ZNF384 ETS1 POLR2A BCL11A SMARCA4 POU5F1 FOXP2 PRDM1

Genomic Location for CDH10 Gene

Chromosome:
5
Start:
24,487,100 bp from pter
End:
24,645,024 bp from pter
Size:
157,925 bases
Orientation:
Minus strand

Genomic View for CDH10 Gene

Genes around CDH10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDH10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDH10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDH10 Gene

Proteins for CDH10 Gene

  • Protein details for CDH10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6N8-CAD10_HUMAN
    Recommended name:
    Cadherin-10
    Protein Accession:
    Q9Y6N8
    Secondary Accessions:
    • Q9ULB3

    Protein attributes for CDH10 Gene

    Size:
    788 amino acids
    Molecular mass:
    88451 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDH10 Gene

Post-translational modifications for CDH10 Gene

  • Glycosylation at Asn 256, Asn 438, Asn 456, and Asn 534
  • Modification sites at PhosphoSitePlus

Other Protein References for CDH10 Gene

Antibody Products

No data available for DME Specific Peptides for CDH10 Gene

Domains & Families for CDH10 Gene

Gene Families for CDH10 Gene

Suggested Antigen Peptide Sequences for CDH10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6N8

UniProtKB/Swiss-Prot:

CAD10_HUMAN :
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain:
  • Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
  • Contains 5 cadherin domains.
genes like me logo Genes that share domains with CDH10: view

Function for CDH10 Gene

Molecular function for CDH10 Gene

GENATLAS Biochemistry:
cadherin 10,T2 cadherin,transmembrane glycoprotein,component of adherens junction,predominantly expressed in brain,putatively involved in synaptic adhesions,axon outgrowth and guidance,also expressed in kidney,prostate,fetal lung
UniProtKB/Swiss-Prot Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene Ontology (GO) - Molecular Function for CDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CDH10: view
genes like me logo Genes that share phenotypes with CDH10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDH10

miRNA for CDH10 Gene

miRTarBase miRNAs that target CDH10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDH10 Gene

Localization for CDH10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDH10 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDH10 Gene COMPARTMENTS Subcellular localization image for CDH10 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDH10: view

Pathways & Interactions for CDH10 Gene

genes like me logo Genes that share pathways with CDH10: view

Gene Ontology (GO) - Biological Process for CDH10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0016337 single organismal cell-cell adhesion NAS 10861224
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with CDH10: view

No data available for SIGNOR curated interactions for CDH10 Gene

Drugs & Compounds for CDH10 Gene

(1) Drugs for CDH10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CDH10: view

Transcripts for CDH10 Gene

Unigene Clusters for CDH10 Gene

Cadherin 10, type 2 (T2-cadherin):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDH10 Gene

No ASD Table

Relevant External Links for CDH10 Gene

GeneLoc Exon Structure for
CDH10
ECgene alternative splicing isoforms for
CDH10

Expression for CDH10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDH10 Gene

mRNA differential expression in normal tissues according to GTEx for CDH10 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.5), Brain - Frontal Cortex (BA9) (x7.4), Brain - Anterior cingulate cortex (BA24) (x6.9), Brain - Cerebellum (x6.7), and Brain - Cortex (x5.4).

Protein differential expression in normal tissues from HIPED for CDH10 Gene

This gene is overexpressed in Frontal cortex (39.2) and Fetal Brain (25.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDH10 Gene



Protein tissue co-expression partners for CDH10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDH10 Gene:

CDH10

SOURCE GeneReport for Unigene cluster for CDH10 Gene:

Hs.92489

mRNA Expression by UniProt/SwissProt for CDH10 Gene:

Q9Y6N8-CAD10_HUMAN
Tissue specificity: Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung.
genes like me logo Genes that share expression patterns with CDH10: view

Primer Products

Orthologs for CDH10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDH10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDH10 34 35
  • 99.87 (n)
oppossum
(Monodelphis domestica)
Mammalia CDH10 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDH10 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDH10 34 35
  • 91.62 (n)
dog
(Canis familiaris)
Mammalia CDH10 34 35
  • 90.36 (n)
mouse
(Mus musculus)
Mammalia Cdh10 34 16 35
  • 88.11 (n)
rat
(Rattus norvegicus)
Mammalia Cdh10 34
  • 87.48 (n)
chicken
(Gallus gallus)
Aves CDH10 34 35
  • 83.29 (n)
lizard
(Anolis carolinensis)
Reptilia CDH10 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdh10 34
  • 75.1 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01067945.1 35
  • 67 (a)
ManyToMany
cdh10 34 35
  • 65.09 (n)
cdh6 35
  • 61 (a)
ManyToMany
Species where no ortholog for CDH10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDH10 Gene

ENSEMBL:
Gene Tree for CDH10 (if available)
TreeFam:
Gene Tree for CDH10 (if available)

Paralogs for CDH10 Gene

Paralogs for CDH10 Gene

(20) SIMAP similar genes for CDH10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDH10: view

Variants for CDH10 Gene

Sequence variations from dbSNP and Humsavar for CDH10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_036102 A breast cancer sample
rs1002462 -- 24,528,027(-) TTGAC(C/T)GAAGC intron-variant
rs1003044 -- 24,526,189(+) GTCCT(A/G)GAGGA intron-variant
rs10037982 -- 24,554,741(+) AAGAT(C/T)TTATC intron-variant
rs10042013 -- 24,554,802(+) TTTTA(G/T)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDH10 Gene

Variant ID Type Subtype PubMed ID
esv1416666 CNV insertion 17803354
esv25919 CNV loss 19812545
esv2657466 CNV deletion 23128226
esv2670513 CNV deletion 23128226
esv2759334 CNV loss 17122850
esv3380329 OTHER inversion 20981092
esv3444242 CNV insertion 20981092
esv3604397 CNV loss 21293372
esv3604398 CNV loss 21293372
nsv1022665 CNV loss 25217958
nsv1131878 CNV deletion 24896259
nsv4765 CNV insertion 18451855
nsv476676 CNV novel sequence insertion 20440878
nsv512848 CNV insertion 21212237
nsv597607 CNV loss 21841781
nsv597608 CNV loss 21841781
nsv7369 OTHER inversion 18451855
nsv830236 CNV loss 17160897

Variation tolerance for CDH10 Gene

Residual Variation Intolerance Score: 3.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDH10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDH10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDH10 Gene

Disorders for CDH10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDH10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search CDH10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDH10

Genetic Association Database (GAD)
CDH10
Human Genome Epidemiology (HuGE) Navigator
CDH10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDH10
genes like me logo Genes that share disorders with CDH10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDH10 Gene

Publications for CDH10 Gene

  1. Common genetic variants on 5p14.1 associate with autism spectrum disorders. (PMID: 19404256) Wang K. … Hakonarson H. (Nature 2009) 3 22 46 64
  2. The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14. (PMID: 10386616) Kools P. … van Roy F. (FEBS Lett. 1999) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. A genome-wide association study of autism reveals a common novel risk locus at 5p14.1. (PMID: 19456320) Ma D. … Pericak-Vance M.A. (Ann. Hum. Genet. 2009) 3 46 64
  5. Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. (PMID: 10861224) Shimoyama Y. … Natori M. (Biochem. J. 2000) 3 4 64

Products for CDH10 Gene

Sources for CDH10 Gene

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