Aliases for CDH1 Gene
External Ids for CDH1 Gene
Previous HGNC Symbols for CDH1 Gene
Previous GeneCards Identifiers for CDH1 Gene
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDH1 Gene
CDH1 (Cadherin 1, Type 1, E-Cadherin (Epithelial)) is a Protein Coding gene. Diseases associated with CDH1 include familial gastric cancer and gastric linitis plastica. Among its related pathways are S-1P Stimulated Signaling and Cell adhesion molecules (CAMs). GO annotations related to this gene include calcium ion binding and beta-catenin binding. An important paralog of this gene is CDH13.
UniProtKB/Swiss-Prot for CDH1 Gene
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.