Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDCP2 Gene

Aliases for CDCP2 Gene

  • CUB Domain Containing Protein 2 2 3 5

External Ids for CDCP2 Gene

Previous GeneCards Identifiers for CDCP2 Gene

  • GC01M054322
  • GC01M054605
  • GC01M052721

Summaries for CDCP2 Gene

GeneCards Summary for CDCP2 Gene

CDCP2 (CUB Domain Containing Protein 2) is a Protein Coding gene. An important paralog of this gene is MFRP.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCP2 Gene

Genomics for CDCP2 Gene

Regulatory Elements for CDCP2 Gene

Genomic Location for CDCP2 Gene

Chromosome:
1
Start:
54,133,074 bp from pter
End:
54,153,770 bp from pter
Size:
20,697 bases
Orientation:
Minus strand

Genomic View for CDCP2 Gene

Genes around CDCP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCP2 Gene

Proteins for CDCP2 Gene

  • Protein details for CDCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VXM1-CDCP2_HUMAN
    Recommended name:
    CUB domain-containing protein 2
    Protein Accession:
    Q5VXM1
    Secondary Accessions:
    • Q6ZWJ3

    Protein attributes for CDCP2 Gene

    Size:
    449 amino acids
    Molecular mass:
    48752 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDCP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDCP2 Gene

Proteomics data for CDCP2 Gene at MOPED

Post-translational modifications for CDCP2 Gene

  • Glycosylation at Asn 40 and Asn 267

Other Protein References for CDCP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDCP2 Gene

Domains & Families for CDCP2 Gene

Protein Domains for CDCP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CDCP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VXM1

UniProtKB/Swiss-Prot:

CDCP2_HUMAN :
  • Contains 3 CUB domains.
Domain:
  • Contains 3 CUB domains.
genes like me logo Genes that share domains with CDCP2: view

No data available for Gene Families for CDCP2 Gene

Function for CDCP2 Gene

genes like me logo Genes that share phenotypes with CDCP2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CDCP2 Gene

Localization for CDCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDCP2 Gene COMPARTMENTS Subcellular localization image for CDCP2 gene
Compartment Confidence
extracellular 4
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for CDCP2 Gene

Pathways & Interactions for CDCP2 Gene

SuperPathways for CDCP2 Gene

No Data Available

Interacting Proteins for CDCP2 Gene

Gene Ontology (GO) - Biological Process for CDCP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CDCP2 Gene

Drugs & Compounds for CDCP2 Gene

No Compound Related Data Available

Transcripts for CDCP2 Gene

mRNA/cDNA for CDCP2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(79) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDCP2 Gene

CUB domain containing protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDCP2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - - - - - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - -
SP6: -
SP7: - - - - -
SP8: - - - -
SP9:

Relevant External Links for CDCP2 Gene

GeneLoc Exon Structure for
CDCP2
ECgene alternative splicing isoforms for
CDCP2

Expression for CDCP2 Gene

mRNA expression in normal human tissues for CDCP2 Gene

mRNA differential expression in normal tissues according to GTEx for CDCP2 Gene

This gene is overexpressed in Spleen (x7.4).

SOURCE GeneReport for Unigene cluster for CDCP2 Gene Hs.568555

genes like me logo Genes that share expression patterns with CDCP2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CDCP2 Gene

Orthologs for CDCP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDCP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDCP2 35
  • 99.03 (n)
  • 98.66 (a)
CDCP2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDCP2 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDCP2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdcp2 36
  • 81 (a)
OneToOne
Cdcp2 16
Cdcp2 35
  • 86.88 (n)
  • 88.03 (a)
oppossum
(Monodelphis domestica)
Mammalia CDCP2 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCP2 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDCP2 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDCP2 36
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cdcp2 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32702 36
  • 3 (a)
ManyToMany
CG42255 36
  • 3 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ZC116.3 36
  • 2 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToOne
Species with no ortholog for CDCP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CDCP2 Gene

ENSEMBL:
Gene Tree for CDCP2 (if available)
TreeFam:
Gene Tree for CDCP2 (if available)

Paralogs for CDCP2 Gene

Paralogs for CDCP2 Gene

(2) SIMAP similar genes for CDCP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDCP2: view

Variants for CDCP2 Gene

Sequence variations from dbSNP and Humsavar for CDCP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3766465 - 54,141,131(-) ACATC(A/G)GAGGC reference, missense
rs599597 -- 54,143,979(-) TTCAC(A/G)GCTTG intron-variant
rs648573 -- 54,139,847(+) GGTGG(C/T)GGCAG reference, synonymous-codon
rs662524 -- 54,140,670(+) CTTGC(A/G)CTGTC intron-variant
rs633883 -- 54,138,903(+) TGCAG(A/G/T)TATTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CDCP2 Gene

Variant ID Type Subtype PubMed ID
nsv871920 CNV Gain 21882294
dgv44e199 CNV Deletion 23128226
esv24487 CNV Loss 19812545
dgv5n21 CNV Loss 19592680

Variation tolerance for CDCP2 Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.26; 94.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDCP2 Gene

HapMap Linkage Disequilibrium report
CDCP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCP2 Gene

Disorders for CDCP2 Gene

Relevant External Links for CDCP2

Genetic Association Database (GAD)
CDCP2
Human Genome Epidemiology (HuGE) Navigator
CDCP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDCP2

No disorders were found for CDCP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDCP2 Gene

Publications for CDCP2 Gene

  1. Investigation of the PARK10 gene in Parkinson disease. (PMID: 17388942) Li Y.J. … Vance J.M. (Ann. Hum. Genet. 2007) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3

Products for CDCP2 Gene

Sources for CDCP2 Gene

Back to Top

Content