Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDCP1 Gene

protein-coding   GIFtS: 54
GCID: GC03M045123

CUB Domain Containing Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CUB Domain Containing Protein 11 2     TRASK2 3
SIMA1352 3 5     CD3182
Membrane Glycoprotein Gp1402 3     CUB Domain-Containing Protein 12
Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein2 3     CD318 Antigen3
Transmembrane And Associated With Src Kinases2 3     

External Ids:    HGNC: 243571   Entrez Gene: 648662   Ensembl: ENSG000001638147   OMIM: 6117355   UniProtKB: Q9H5V83   

Export aliases for CDCP1 gene to outside databases

Previous GC identifers: GC03M044303 GC03M044943 GC03M045084 GC03M045098


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDCP1 Gene:
This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate
for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular
events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript
variants of this gene. (provided by RefSeq, May 2013)

GeneCards Summary for CDCP1 Gene: 
CDCP1 (CUB domain containing protein 1) is a protein-coding gene. Diseases associated with CDCP1 include lung cancer, and lung adenocarcinoma.

UniProtKB/Swiss-Prot: CDCP1_HUMAN, Q9H5V8
Function: May be involved in cell adhesion and cell matrix association. May play a role in the regulation of
anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker
for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved
in tumor progression and metastasis

Gene Wiki entry for CDCP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDCP1 gene promoter:
         c-Fos   C/EBPbeta   AP-1   AML1a   JunB   Fra-1   FosB   PPAR-gamma1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDCP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDCP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDCP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

CDCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDCP1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M045123:  view genomic region     (about GC identifiers)

Start:
45,123,769 bp from pter      End:
45,187,914 bp from pter
Size:
64,146 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDCP1_HUMAN, Q9H5V8 (See protein sequence)
Recommended Name: CUB domain-containing protein 1 precursor  
Size: 836 amino acids; 92932 Da
Subunit: Interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease
ST14/MT-SP1. Also interacts with SRC and PRKCG/protein kinase C gamma
Subcellular location: Isoform 1: Cell membrane; Single-pass membrane protein (Potential). Note=Shedding may also
lead to a soluble peptide
Subcellular location: Isoform 3: Secreted
Sequence caution: Sequence=BAB15388.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q49UB4 Q6NT71 Q6U9Y2 Q8WU91 Q96QU7 Q9H676 Q9H8C2
Alternative splicing: 3 isoforms:  Q9H5V8-1   Q9H5V8-2   Q9H5V8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDCP1: NX_Q9H5V8

Explore proteomics data for CDCP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C
    gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog.
    Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5
  • UniProtKB: N-glycosylated
  • UniProtKB: A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80
    kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its
    N-terminal side. Converted to p80 by plasmin, a trypsin-like protease
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H5V8

  • CDCP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDCP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_073753.3  NP_835488.1  

    ENSEMBL proteins: 
     ENSP00000296129   ENSP00000399342  

    Human Recombinant Protein Products for CDCP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CDCP1
    OriGene Protein Over-expression Lysate for CDCP1
    OriGene MassSpec for CDCP1 
    OriGene Custom Protein Services for CDCP1
    GenScript Custom Purified and Recombinant Proteins Services for CDCP1
    Novus Biologicals CDCP1 Proteins
    Novus Biologicals CDCP1 Lysates
    Sino Biological Recombinant Protein for CDCP1
    Sino Biological Cell Lysate for CDCP1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDCP1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    CDCP1 for ontologies           About GeneDecksing



    CDCP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CDCP1
    Cell Signaling Technology (CST) Antibodies for CDCP1 
    OriGene Antibodies for CDCP1
    OriGene Custom Antibody Services for CDCP1
    GenScript Custom Superior Antibodies Services for CDCP1
    Novus Biologicals CDCP1 Antibodies
    Abcam antibodies for CDCP1
    Cloud-Clone Corp. Antibodies for CDCP1 
    ThermoFisher Antibodies for CDCP1
    LSBio Antibodies in human, mouse, rat for CDCP1 

    Assay Products for CDCP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDCP1
    R&D Systems ELISAs for CDCP1
    GenScript Custom Assay Services for CDCP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDCP1 
    Cloud-Clone Corp. CLIAs for CDCP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    1 InterPro protein domain:
     IPR000859 CUB_dom

    Graphical View of Domain Structure for InterPro Entry Q9H5V8

    ProtoNet protein and cluster: Q9H5V8

    UniProtKB/Swiss-Prot: CDCP1_HUMAN, Q9H5V8
    Similarity: Contains 1 CUB domain


    CDCP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDCP1_HUMAN, Q9H5V8
    Function: May be involved in cell adhesion and cell matrix association. May play a role in the regulation of
    anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker
    for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved
    in tumor progression and metastasis

    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cdcp1):

     behavior/neurological  integument  mortality/aging  normal  tumorigenesis 

    CDCP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdcp1tm1.2Moas for CDCP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDCP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDCP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDCP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDCP1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CDCP1:
    hsa-mir-30a (MIRT005178), hsa-mir-1 (MIRT001377)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDCP1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CDCP1:
    hsa-miR-3163 hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-944 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDCP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDCP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDCP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDCP1
    Sirion Biotech Customized adenovirus for overexpression of CDCP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDCP1 (see all 13)
    OriGene ORF clones in mouse, rat for CDCP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDCP1 (NM_178181)
    Sino Biological Human cDNA Clone for CDCP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDCP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCP1
    Sirion Biotech Customized lentivirus for stable overexpression of CDCP1 
                         Customized lentivirus expression plasmids for stable overexpression of CDCP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDCP1
    Search LifeMap BioReagents cell lines for CDCP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDCP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Lymphocyte Signaling
    Lymphocyte Signaling
    2Adhesion
    Adhesion
    3Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for CDCP1
        Wnt / Hedgehog / Notch
    Lymphocyte Signaling
    Adhesion




    CDCP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDCP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for CDCP1 (Q9H5V82, 3 ENSP000002961294) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCDQ056552, 3, ENSP000003316024MINT-62341 MINT-62334 MINT-62336 MINT-62333 MINT-62332 MINT-62339 I2D: score=3 STRING: ENSP00000331602
    SRCP129312, 3, ENSP000003509414MINT-62337 MINT-62342 I2D: score=3 STRING: ENSP00000350941
    ST14Q9Y5Y63, ENSP000002787424I2D: score=1 STRING: ENSP00000278742
    PLGP007473, ENSP000003089384I2D: score=1 STRING: ENSP00000308938
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDCP1

    Search CenterWatch for drugs/clinical trials and news about CDCP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDCP1 gene (2 alternative transcripts): 
    NM_022842.4  NM_178181.2  

    Unigene Cluster for CDCP1:

    CUB domain containing protein 1
    Hs.476093  [show with all ESTs]
    Unigene Representative Sequence: NM_022842
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296129(uc003com.3) ENST00000425231(uc003con.3) ENST00000490471

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDCP1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CDCP1:
    hsa-miR-3163 hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-944 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDCP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDCP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDCP1
    Clone
    Products:
         
    OriGene clones in human, mouse for CDCP1 (see all 13)
    OriGene ORF clones in mouse, rat for CDCP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CDCP1 (NM_178181)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDCP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCP1
    Sirion Biotech Customized lentivirus for stable overexpression of CDCP1 
                         Customized lentivirus expression plasmids for stable overexpression of CDCP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CDCP1
    OriGene qSTAR qPCR primer pairs in human, mouse for CDCP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDCP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDCP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDCP1

    Additional mRNA sequence: 

    AF468010.1 AK023834.1 AK026187.1 AK026329.1 AK026622.1 AK314441.1 AY026461.1 AY167484.1 
    AY358779.1 AY375452.1 BC021099.1 BC069254.1 

    8 DOTS entries:

    DT.444481  DT.97861092  DT.100787843  DT.95271348  DT.100787841  DT.100787842  DT.426143  DT.97861080 

    24/176 AceView cDNA sequences (see all 176):

    BM840669 BQ962997 AA132760 AA922764 BM893567 AI539070 BC021099 NM_178181 
    BM893690 CA307237 BC069254 CB157642 BM701518 AI202358 BM966953 AI420501 
    AA554121 CB129853 AA292689 NM_022842 BM044552 BM840003 BX473477 BM966788 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDCP1 expression in normal human tissues (normalized intensities)      CDCP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTGGTAA
    CDCP1 Expression
    About this image


    CDCP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 6 entries
             vagina ; squamous epithelial cells   
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Ureteric Bud Cells Ureteric Bud
             Renal Collecting Duct System
             kidney ; cells in tubules   
     
     Uterus
             uterus, post-menopause ; glandular cells   
             endometrial endothelial cell   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Conventional Dendritic Cells II Spleen
             alveolar macrophages   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
             alveolar macrophages   

    See CDCP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDCP1

    SOURCE GeneReport for Unigene cluster: Hs.476093

    UniProtKB/Swiss-Prot: CDCP1_HUMAN, Q9H5V8
    Tissue specificity: Highly expressed in mitotic cells with low expression during interphase. Detected at highest
    levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated
    in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also
    expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells

        SABiosciences Custom PCR Arrays for CDCP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDCP1
    OriGene qSTAR qPCR primer pairs in human, mouse for CDCP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDCP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDCP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDCP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CDCP1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdcp11 , 5 CUB domain containing protein 11, 5 82.51(n)1
    81.27(a)1
      9 (73.92 cM)5
    1093321  NM_133974.31  NP_598735.21 
     1231708245 
    chicken
    (Gallus gallus)
    Aves CDCP11 CUB domain containing protein 1 59.43(n)
    54.29(a)
      420703  XM_418802.3  XP_418802.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDCP16
    Uncharacterized protein
    43(a)
    1 ↔ 1
    GL343611.1(212358-284483)
    zebrafish
    (Danio rerio)
    Actinopterygii cdcp1a1 CUB domain containing protein 1a 41.7(n)
    26.62(a)
      541520  NM_001014333.1  NP_001014355.1 


    ENSEMBL Gene Tree for CDCP1 (if available)
    TreeFam Gene Tree for CDCP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1484 SNPs in CDCP1 are shown (see all 1484)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1417135381,2
    C--45123286(+) GAAAGA/GGGATT 1 -- ds50010--------
    rs1836552721,2
    --45123334(+) AGATAC/TACAGT 1 -- ds50010--------
    rs1890984331,2
    --45123455(+) ATCCAA/GTGTGC 1 -- ds50010--------
    rs1505593921,2
    --45123496(+) GGTGGG/TGGCCA 1 -- ds50010--------
    rs765637811,2
    F--45123527(+) TGCTCT/GCCCTT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1395937651,2
    --45123541(+) TTTTGC/TTCTGG 1 -- ds50010--------
    rs1169855511,2
    C,F--45123593(+) AGTGAT/CTAGGG 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1174081421,2
    C,F--45123686(+) GAACAG/AAACAA 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1442683691,2
    --45123693(+) ACAAGC/TCCTGG 1 -- ds50010--------
    rs1921099191,2
    --45123818(+) TCTGCC/TTCACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CDCP1 (45123769 - 45187914 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CDCP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2725219CNV Deletion23290073
    esv2743358CNV Deletion23290073
    esv1680465CNV Deletion17803354
    nsv512799CNV Insertion21212237
    esv2626441CNV Insertion19546169
    nsv523767CNV Loss19592680
    nsv834676CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CDCP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDCP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611735    OMIM disorders: --

    12 diseases for CDCP1:    About MalaCards
    lung cancer    lung adenocarcinoma    peritonitis    renal cell carcinoma
    melanoma    pancreatic cancer    adenocarcinoma    colorectal cancer
    pancreatitis    prostate cancer    prostatitis    leukemia


    CDCP1 for disorders           About GeneDecksing


    Export disorders for CDCP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDCP1 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with CDCP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. (PubMed id 11466621)1, 2, 3 Scherl-Mostageer M.... Schweifer N. (2001)
    2. Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia. (PubMed id 14739293)1, 2, 9 Brown T.A.... Carter W.G. (2004)
    3. Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS. (PubMed id 16404722)1, 2, 9 Andre M.... Le Naour F. (2006)
    4. Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells. (PubMed id 17335815)1, 2 Perry S.E....Blair G.E. (2007)
    5. The C2 domain of PKCdelta is a phosphotyrosine binding domain. (PubMed id 15851033)1, 2 Benes C.H.... Soltoff S.P. (2005)
    6. Adhesion signaling by a novel mitotic substrate of src kinases. (PubMed id 16007225)1, 2 Bhatt A.S.... Moasser M.M. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin. (PubMed id 15153610)1, 2 Buehring H.-J....Lammers R. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. CDCP1 is a novel marker for hematopoietic stem cells. (PubMed id 12799299)1, 2 Conze T.... Buehring H.-J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64866 HGNC: 24357 AceView: CDCP1 Ensembl:ENSG00000163814 euGenes: HUgn64866
    ECgene: CDCP1 H-InvDB: CDCP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDCP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDCP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDCP1 gene:
    Search GeneIP for patents involving CDCP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CDCP1 (CDCP1)   Browse Cell Culture Products  
     ELISAs for CDCP1 (CDCP1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CDCP1   OriGene RNAi products in human, mouse, rat for CDCP1  
     OriGene qPCR primer pairs and template standards for CDCP1   OriGene Protein Over-expression Lysate for CDCP1  
     OriGene MassSpec something-or-other for CDCP1   OriGene clones in human, mouse for CDCP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDCP1   OriGene Purified Protein for CDCP1  
     OriGene ORF clones in mouse, rat for CDCP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDCP1   OriGene Custom Protein Services for CDCP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDCP1
     QIAGEN SeqTarget long-range PCR primers for resequencing CDCP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDCP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDCP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDCP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDCP1
     GenScript Custom Purified and Recombinant Proteins Services for CDCP1 GenScript cDNA clones with any tag delivered in your preferred vector for CDCP1
     GenScript Custom Assay Services for CDCP1 GenScript Custom Superior Antibodies Services for CDCP1
     GenScript Custom overexpressing Cell Line Services for CDCP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CDCP1 

     Regulatory tfbs in CDCP1 promoter
     Search Chromatin IP Primers for CDCP1
     RT2 qPCR Primer Assay in human, mouse, rat CDCP1
     GNC Network for CDCP1
     SABiosciences Custom PCR Arrays for CDCP1
     Search Tocris compounds for CDCP1
     Proteins and Antibodies for CDCP1
     Cell Lysates for CDCP1
     cDNA Clones for CDCP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CDCP1 antibodies
     CDCP1 proteins
     CDCP1 lysates
     Antibodies for CDCP1
     See all of Abcam's Antibodies, Kits and Proteins for CDCP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CDCP1
     Antibodies for CDCP1
     ELISAs for CDCP1
     CLIAs for CDCP1
     Search LifeMap BioReagents cell lines for CDCP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCP1
     SwitchGear 3'UTR luciferase reporter plasmids for CDCP1
     SwitchGear Promoter luciferase reporter plasmids for CDCP1
     ThermoFisher Antibodies for CDCP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CDCP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDCP1
    Customized:
     lentivirus for stable overexpression of CDCP1
     lentivirus expression plasmids for stable overexpression of CDCP1
     adenovirus for overexpression of CDCP1
     LSBio Antibodies in human, mouse, rat for CDCP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDCP1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4