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Aliases for CDCP1 Gene

Aliases for CDCP1 Gene

  • CUB Domain Containing Protein 1 2 3 5
  • Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein 3 4
  • Transmembrane And Associated With Src Kinases 3 4
  • Membrane Glycoprotein Gp140 3 4
  • SIMA135 3 4
  • TRASK 3 4
  • CUB Domain-Containing Protein 1 3
  • CD318 Antigen 4
  • CD318 3

External Ids for CDCP1 Gene

Previous GeneCards Identifiers for CDCP1 Gene

  • GC03M044303
  • GC03M044943
  • GC03M045084
  • GC03M045098

Summaries for CDCP1 Gene

Entrez Gene Summary for CDCP1 Gene

  • This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for CDCP1 Gene

CDCP1 (CUB Domain Containing Protein 1) is a Protein Coding gene. Diseases associated with CDCP1 include Colorectal Cancer. Among its related pathways are Adhesion and NF-kappaB Signaling.

UniProtKB/Swiss-Prot for CDCP1 Gene

  • May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.

Gene Wiki entry for CDCP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCP1 Gene

Genomics for CDCP1 Gene

Regulatory Elements for CDCP1 Gene

Enhancers for CDCP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G045165 2 FANTOM5 Ensembl ENCODE dbSUPER 19.6 -21.8 -21823 5.3 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF766 FOS KLF13 DEK CDCP1 TMEM158 ENSG00000202268 LARS2-AS1 SLC6A20 LIMD1 RPS24P8 LOC101928636
GH03G045052 2 FANTOM5 Ensembl ENCODE dbSUPER 16.4 +86.9 86893 13.7 HDGF PKNOX1 CREB3L1 ARNT YY1 ZNF766 FOS KLF13 REST TBX21 EXOSC7 CLEC3B XCR1 CDCP1 ZNF660 RN7SL145P RNU5B-3P TMEM158 ENSG00000202268 ZDHHC3
GH03G045117 2 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +23.4 23434 10.7 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF766 FOS DEK ZHX2 REST LIMD1 TMEM158 CDCP1 RNU5B-3P CLEC3B XCR1 ENSG00000202268 ZNF502 LOC105377059
GH03G045130 2 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +10.4 10431 11.1 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF766 CBX5 FOS KLF13 RNU5B-3P CLEC3B TMEM158 ZNF501 ENSG00000202268 XCR1 CDCP1 LOC105377059
GH03G045090 1.6 Ensembl ENCODE dbSUPER 11.7 +53.7 53702 3.8 HDGF PKNOX1 CREB3L1 ARNT SIN3A ZNF766 CBX5 FOS KLF13 DEK XCR1 CDCP1 LIMD1 TMEM158 EXOSC7 LOC105377059
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDCP1 on UCSC Golden Path with GeneCards custom track

Promoters for CDCP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151668 422 1201 ZNF777 SUZ12 MAX RBBP5 ETS1 ZNF316 POLR2A ZNF547 NFE2 MAFK

Genomic Location for CDCP1 Gene

Chromosome:
3
Start:
45,082,274 bp from pter
End:
45,146,422 bp from pter
Size:
64,149 bases
Orientation:
Minus strand

Genomic View for CDCP1 Gene

Genes around CDCP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCP1 Gene

Proteins for CDCP1 Gene

  • Protein details for CDCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5V8-CDCP1_HUMAN
    Recommended name:
    CUB domain-containing protein 1
    Protein Accession:
    Q9H5V8
    Secondary Accessions:
    • Q49UB4
    • Q6NT71
    • Q6U9Y2
    • Q8WU91
    • Q96QU7
    • Q9H676
    • Q9H8C2

    Protein attributes for CDCP1 Gene

    Size:
    836 amino acids
    Molecular mass:
    92932 Da
    Quaternary structure:
    • Interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. Also interacts with SRC and PRKCG/protein kinase C gamma.
    SequenceCaution:
    • Sequence=BAB15388.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDCP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDCP1 Gene

Post-translational modifications for CDCP1 Gene

  • A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.
  • N-glycosylated.
  • Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.
  • Glycosylation at posLast=3939, Asn122, Asn180, posLast=205205, Asn270, posLast=310310, Asn339, and posLast=386386
  • Modification sites at PhosphoSitePlus

Other Protein References for CDCP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDCP1 (CDCP1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CDCP1

Assay Products

No data available for DME Specific Peptides for CDCP1 Gene

Domains & Families for CDCP1 Gene

Gene Families for CDCP1 Gene

Protein Domains for CDCP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDCP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDCP1: view

No data available for UniProtKB/Swiss-Prot for CDCP1 Gene

Function for CDCP1 Gene

Molecular function for CDCP1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.

Gene Ontology (GO) - Molecular Function for CDCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CDCP1: view
genes like me logo Genes that share phenotypes with CDCP1: view

Animal Models for CDCP1 Gene

MGI Knock Outs for CDCP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDCP1

CRISPR Products

miRNA for CDCP1 Gene

miRTarBase miRNAs that target CDCP1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDCP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDCP1 Gene

Localization for CDCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCP1 Gene

Isoform 1: Cell membrane; Single-pass membrane protein. Note=Shedding may also lead to a soluble peptide.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDCP1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CDCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDCP1: view

Pathways & Interactions for CDCP1 Gene

genes like me logo Genes that share pathways with CDCP1: view

Pathways by source for CDCP1 Gene

3 Cell Signaling Technology pathways for CDCP1 Gene

Gene Ontology (GO) - Biological Process for CDCP1 Gene

None

No data available for SIGNOR curated interactions for CDCP1 Gene

Drugs & Compounds for CDCP1 Gene

No Compound Related Data Available

Transcripts for CDCP1 Gene

Unigene Clusters for CDCP1 Gene

CUB domain containing protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDCP1

Alternative Splicing Database (ASD) splice patterns (SP) for CDCP1 Gene

No ASD Table

Relevant External Links for CDCP1 Gene

GeneLoc Exon Structure for
CDCP1
ECgene alternative splicing isoforms for
CDCP1

Expression for CDCP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDCP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDCP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.0), Skin - Not Sun Exposed (Suprapubic) (x4.8), Minor Salivary Gland (x4.7), and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for CDCP1 Gene

This gene is overexpressed in Nasal epithelium (57.4) and Breast (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDCP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CDCP1 Gene:

CDCP1

SOURCE GeneReport for Unigene cluster for CDCP1 Gene:

Hs.476093

mRNA Expression by UniProt/SwissProt for CDCP1 Gene:

Q9H5V8-CDCP1_HUMAN
Tissue specificity: Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells.

Evidence on tissue expression from TISSUES for CDCP1 Gene

  • Kidney(4.2)
  • Skin(4.2)
  • Intestine(2.9)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with CDCP1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDCP1 Gene

Orthologs for CDCP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDCP1 34 35
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia CDCP1 34 35
  • 86.56 (n)
cow
(Bos Taurus)
Mammalia CDCP1 34 35
  • 83.85 (n)
mouse
(Mus musculus)
Mammalia Cdcp1 34 16 35
  • 82.51 (n)
rat
(Rattus norvegicus)
Mammalia Cdcp1 34
  • 82.35 (n)
oppossum
(Monodelphis domestica)
Mammalia CDCP1 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCP1 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDCP1 34 35
  • 59.34 (n)
lizard
(Anolis carolinensis)
Reptilia CDCP1 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdcp1 34
  • 53.81 (n)
zebrafish
(Danio rerio)
Actinopterygii cdcp1a 34 35
  • 41.86 (n)
CABZ01049057.1 35
  • 26 (a)
OneToMany
CDCP1 (2 of 3) 35
  • 20 (a)
OneToMany
Species where no ortholog for CDCP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCP1 Gene

ENSEMBL:
Gene Tree for CDCP1 (if available)
TreeFam:
Gene Tree for CDCP1 (if available)

Paralogs for CDCP1 Gene

No data available for Paralogs for CDCP1 Gene

Variants for CDCP1 Gene

Sequence variations from dbSNP and Humsavar for CDCP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000019301 -- 45,140,929(+) GGCGT(A/G)GTGGC intron-variant
rs1000059862 -- 45,122,382(+) CAGGT(A/G)ATCCA intron-variant
rs1000107796 -- 45,107,190(+) AAGTG(G/T)TGTGT intron-variant
rs1000189027 -- 45,116,436(+) TTAAA(A/G)TCATC intron-variant
rs1000202769 -- 45,092,851(+) CCCAA(C/T)GCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDCP1 Gene

Variant ID Type Subtype PubMed ID
esv1680465 CNV deletion 17803354
esv2626441 CNV insertion 19546169
esv2725219 CNV deletion 23290073
esv2743358 CNV deletion 23290073
esv2762327 CNV loss 21179565
esv3568719 CNV loss 25503493
esv3893691 CNV gain 25118596
nsv512799 CNV insertion 21212237
nsv523767 CNV loss 19592680
nsv834676 CNV gain+loss 17160897

Variation tolerance for CDCP1 Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDCP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDCP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCP1 Gene

Disorders for CDCP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDCP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CDCP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDCP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDCP1
genes like me logo Genes that share disorders with CDCP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDCP1 Gene

Publications for CDCP1 Gene

  1. Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS. (PMID: 16404722) Andre M. … Le Naour F. (Proteomics 2006) 3 4 22 64
  2. Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia. (PMID: 14739293) Brown T.A. … Carter W.G. (J. Biol. Chem. 2004) 3 4 22 64
  3. Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. (PMID: 11466621) Scherl-Mostageer M. … Schweifer N. (Oncogene 2001) 2 3 4 64
  4. Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers. (PMID: 19318475) Wong C.H. … Moasser M.M. (Clin. Cancer Res. 2009) 3 22 64
  5. Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer model. (PMID: 18483259) Siva A.C. … Xin H. (Cancer Res. 2008) 3 22 64

Products for CDCP1 Gene

  • Addgene plasmids for CDCP1

Sources for CDCP1 Gene

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