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Aliases for CDCP1 Gene

Aliases for CDCP1 Gene

  • CUB Domain Containing Protein 1 2 3 5
  • Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein 3 4
  • Transmembrane And Associated With Src Kinases 3 4
  • Membrane Glycoprotein Gp140 3 4
  • SIMA135 3 4
  • TRASK 3 4
  • CD318 Antigen 4
  • CD318 3

External Ids for CDCP1 Gene

Previous GeneCards Identifiers for CDCP1 Gene

  • GC03M044303
  • GC03M044943
  • GC03M045084
  • GC03M045098

Summaries for CDCP1 Gene

Entrez Gene Summary for CDCP1 Gene

  • This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for CDCP1 Gene

CDCP1 (CUB Domain Containing Protein 1) is a Protein Coding gene. Among its related pathways are NF-kappaB Signaling and Adhesion.

UniProtKB/Swiss-Prot for CDCP1 Gene

  • May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.

Gene Wiki entry for CDCP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCP1 Gene

Genomics for CDCP1 Gene

Regulatory Elements for CDCP1 Gene

Enhancers for CDCP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDCP1 on UCSC Golden Path with GeneCards custom track

Promoters for CDCP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDCP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDCP1 Gene

45,082,274 bp from pter
45,146,422 bp from pter
64,149 bases
Minus strand

Genomic View for CDCP1 Gene

Genes around CDCP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCP1 Gene

Proteins for CDCP1 Gene

  • Protein details for CDCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CUB domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q49UB4
    • Q6NT71
    • Q6U9Y2
    • Q8WU91
    • Q96QU7
    • Q9H676
    • Q9H8C2

    Protein attributes for CDCP1 Gene

    836 amino acids
    Molecular mass:
    92932 Da
    Quaternary structure:
    • Interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. Also interacts with SRC and PRKCG/protein kinase C gamma.
    • Sequence=BAB15388.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CDCP1 Gene


neXtProt entry for CDCP1 Gene

Proteomics data for CDCP1 Gene at MOPED

Post-translational modifications for CDCP1 Gene

  • A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.
  • N-glycosylated.
  • Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.
  • Glycosylation at Asn 39, Asn 122, Asn 180, Asn 205, Asn 270, Asn 310, Asn 339, and Asn 386
  • Modification sites at PhosphoSitePlus

Other Protein References for CDCP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDCP1 (CDCP1)

No data available for DME Specific Peptides for CDCP1 Gene

Domains & Families for CDCP1 Gene

Gene Families for CDCP1 Gene

Protein Domains for CDCP1 Gene


Suggested Antigen Peptide Sequences for CDCP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUB domain.
  • Contains 1 CUB domain.
genes like me logo Genes that share domains with CDCP1: view

Function for CDCP1 Gene

Molecular function for CDCP1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.
genes like me logo Genes that share phenotypes with CDCP1: view

Animal Models for CDCP1 Gene

MGI Knock Outs for CDCP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CDCP1

miRNA for CDCP1 Gene

miRTarBase miRNAs that target CDCP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDCP1 Gene

Localization for CDCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCP1 Gene

Isoform 1: Cell membrane; Single-pass membrane protein. Note=Shedding may also lead to a soluble peptide.
Isoform 3: Secreted.

Subcellular locations from

Jensen Localization Image for CDCP1 Gene COMPARTMENTS Subcellular localization image for CDCP1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDCP1: view

Pathways & Interactions for CDCP1 Gene

genes like me logo Genes that share pathways with CDCP1: view

Pathways by source for CDCP1 Gene

3 Cell Signaling Technology pathways for CDCP1 Gene

Gene Ontology (GO) - Biological Process for CDCP1 Gene


No data available for SIGNOR curated interactions for CDCP1 Gene

Drugs & Compounds for CDCP1 Gene

No Compound Related Data Available

Transcripts for CDCP1 Gene

Unigene Clusters for CDCP1 Gene

CUB domain containing protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDCP1 Gene

No ASD Table

Relevant External Links for CDCP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDCP1 Gene

mRNA expression in normal human tissues for CDCP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDCP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.0), Skin - Not Sun Exposed (Suprapubic) (x4.8), Minor Salivary Gland (x4.7), and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for CDCP1 Gene

This gene is overexpressed in Nasal epithelium (57.4) and Breast (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CDCP1 Gene

SOURCE GeneReport for Unigene cluster for CDCP1 Gene Hs.476093

mRNA Expression by UniProt/SwissProt for CDCP1 Gene

Tissue specificity: Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells.
genes like me logo Genes that share expression patterns with CDCP1: view

Primer Products

No data available for Protein tissue co-expression partners for CDCP1 Gene

Orthologs for CDCP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDCP1 35
  • 83.85 (n)
  • 80.22 (a)
CDCP1 36
  • 80 (a)
(Canis familiaris)
Mammalia CDCP1 35
  • 86.56 (n)
  • 85.2 (a)
CDCP1 36
  • 85 (a)
(Mus musculus)
Mammalia Cdcp1 35
  • 82.51 (n)
  • 81.27 (a)
Cdcp1 16
Cdcp1 36
  • 81 (a)
(Pan troglodytes)
Mammalia CDCP1 35
  • 99.08 (n)
  • 98.56 (a)
CDCP1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cdcp1 35
  • 82.35 (n)
  • 81.51 (a)
(Monodelphis domestica)
Mammalia CDCP1 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia CDCP1 36
  • 63 (a)
(Gallus gallus)
Aves CDCP1 35
  • 59.34 (n)
  • 54.17 (a)
CDCP1 36
  • 52 (a)
(Anolis carolinensis)
Reptilia CDCP1 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cdcp1 35
  • 53.81 (n)
  • 46.55 (a)
(Danio rerio)
Actinopterygii cdcp1a 35
  • 41.86 (n)
  • 26.7 (a)
CABZ01049057.1 36
  • 26 (a)
CDCP1 (2 of 3) 36
  • 20 (a)
cdcp1a 36
  • 25 (a)
Species with no ortholog for CDCP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCP1 Gene

Gene Tree for CDCP1 (if available)
Gene Tree for CDCP1 (if available)

Paralogs for CDCP1 Gene

No data available for Paralogs for CDCP1 Gene

Variants for CDCP1 Gene

Sequence variations from dbSNP and Humsavar for CDCP1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3749191 - 45,093,330(+) CTTGT(C/T)GGAAG reference, missense
rs9874077 - 45,086,023(+) TGTTG(C/T)CATTG reference, missense
rs35428731 - 45,089,117(+) CCACC(A/G)CTGCG reference, missense
rs12947 -- 45,082,859(+) TTTTA(C/T)GTAAG utr-variant-3-prime
rs1079472 -- 45,098,774(-) CAATA(C/T)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDCP1 Gene

Variant ID Type Subtype PubMed ID
nsv834676 CNV Gain+Loss 17160897
nsv523767 CNV Loss 19592680
esv2725219 CNV Deletion 23290073
esv2743358 CNV Deletion 23290073
esv1680465 CNV Deletion 17803354
nsv512799 CNV Insertion 21212237
esv2626441 CNV Insertion 19546169

Variation tolerance for CDCP1 Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CDCP1 Gene

Disorders for CDCP1 Gene

Relevant External Links for CDCP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CDCP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDCP1 Gene

Publications for CDCP1 Gene

  1. Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. (PMID: 11466621) Scherl-Mostageer M. … Schweifer N. (Oncogene 2001) 2 3 4 67
  2. Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers. (PMID: 19318475) Wong C.H. … Moasser M.M. (Clin. Cancer Res. 2009) 3 23
  3. Targeting CUB domain-containing protein 1 with a monoclonal antibody inhibits metastasis in a prostate cancer model. (PMID: 18483259) Siva A.C. … Xin H. (Cancer Res. 2008) 3 23
  4. CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma. (PMID: 17785447) Uekita T. … Sakai R. (Mol. Cell. Biol. 2007) 3 23
  5. Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS. (PMID: 16404722) Andre M. … Le Naour F. (Proteomics 2006) 3 23

Products for CDCP1 Gene

Sources for CDCP1 Gene