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CDCP1 Gene

protein-coding   GIFtS: 54
GCID: GC03M045123

CUB Domain Containing Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CUB Domain Containing Protein 11 2     TRASK2 3
SIMA1352 3 5     CD3182
Membrane Glycoprotein Gp1402 3     CUB Domain-Containing Protein 12
Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein2 3     CD318 Antigen3
Transmembrane And Associated With Src Kinases2 3     

External Ids:    HGNC: 243571   Entrez Gene: 648662   Ensembl: ENSG000001638147   OMIM: 6117355   UniProtKB: Q9H5V83   

Export aliases for CDCP1 gene to outside databases

Previous GC identifers: GC03M044303 GC03M044943 GC03M045084 GC03M045098


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDCP1 Gene:
This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate
for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular
events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript
variants of this gene. (provided by RefSeq, May 2013)

GeneCards Summary for CDCP1 Gene:
CDCP1 (CUB domain containing protein 1) is a protein-coding gene. Diseases associated with CDCP1 include clear cell renal cell carcinoma, and lung adenocarcinoma.

UniProtKB/Swiss-Prot: CDCP1_HUMAN, Q9H5V8
Function: May be involved in cell adhesion and cell matrix association. May play a role in the regulation of
anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker
for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved
in tumor progression and metastasis

Gene Wiki entry for CDCP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDCP1 gene promoter:
         c-Fos   C/EBPbeta   AP-1   AML1a   JunB   Fra-1   FosB   PPAR-gamma1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDCP1 promoter sequence
   Search Chromatin IP Primers for CDCP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDCP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

CDCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDCP1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M045123:  view genomic region     (about GC identifiers)

Start:
45,123,769 bp from pter      End:
45,187,914 bp from pter
Size:
64,146 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDCP1_HUMAN, Q9H5V8 (See protein sequence)
Recommended Name: CUB domain-containing protein 1 precursor  
Size: 836 amino acids; 92932 Da
Subunit: Interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease
ST14/MT-SP1. Also interacts with SRC and PRKCG/protein kinase C gamma
Sequence caution: Sequence=BAB15388.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q49UB4 Q6NT71 Q6U9Y2 Q8WU91 Q96QU7 Q9H676 Q9H8C2
Alternative splicing: 3 isoforms:  Q9H5V8-1   Q9H5V8-2   Q9H5V8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDCP1: NX_Q9H5V8

Explore proteomics data for CDCP1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C
    gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog.
    Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-51
  • N-glycosylated1
  • A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80
    kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its
    N-terminal side. Converted to p80 by plasmin, a trypsin-like protease1
  • Glycosylation2 at Asn39, Asn122, Asn180, Asn205, Asn270, Asn310, Asn339, Asn386
  • Modification sites at PhosphoSitePlus

  • See CDCP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_073753.3  NP_835488.1  

    ENSEMBL proteins: 
     ENSP00000296129   ENSP00000399342  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    1 InterPro protein domain:
     IPR000859 CUB_dom

    Graphical View of Domain Structure for InterPro Entry Q9H5V8

    ProtoNet protein and cluster: Q9H5V8

    UniProtKB/Swiss-Prot: CDCP1_HUMAN, Q9H5V8
    Similarity: Contains 1 CUB domain


    CDCP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDCP1_HUMAN, Q9H5V8
    Function: May be involved in cell adhesion and cell matrix association. May play a role in the regulation of
    anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker
    for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved
    in tumor progression and metastasis

    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cdcp1):

     behavior/neurological  integument  mortality/aging  normal  tumorigenesis 

    CDCP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdcp1tm1.2Moas for CDCP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDCP1
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    miRNA
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    miRTarBase miRNAs that target CDCP1:
    hsa-mir-335-5p (MIRT017343), hsa-mir-30a-5p (MIRT005178), hsa-mir-1 (MIRT001377), hsa-mir-124-3p (MIRT022365)

    Block miRNA regulation of human, mouse, rat CDCP1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CDCP1:
    hsa-miR-3163 hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-944 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDCP1 3' UTR sequence
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    Sino Biological Human cDNA Clone for CDCP1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCP1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDCP1_HUMAN, Q9H5V8: Isoform 1: Cell membrane; Single-pass membrane protein (Potential). Note=Shedding may also
    lead to a soluble peptide
    CDCP1_HUMAN, Q9H5V8: Isoform 3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    CDCP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDCP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    2Lymphocyte Signaling
    Lymphocyte Signaling
    3Adhesion
    Adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for CDCP1
        Wnt / Hedgehog / Notch
    Lymphocyte Signaling
    Adhesion




    CDCP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDCP1
    Interactions:

        GeneGlobe Interaction Network for CDCP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for CDCP1 (Q9H5V82, 3 ENSP000002961294) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCDQ056552, 3, ENSP000003316024MINT-62341 MINT-62334 MINT-62336 MINT-62333 MINT-62332 MINT-62339 I2D: score=3 STRING: ENSP00000331602
    SRCP129312, 3, ENSP000003509414MINT-62337 MINT-62342 I2D: score=3 STRING: ENSP00000350941
    ST14Q9Y5Y63, ENSP000002787424I2D: score=1 STRING: ENSP00000278742
    PLGP007473, ENSP000003089384I2D: score=1 STRING: ENSP00000308938
    EGFRP005333, ENSP000002754934I2D: score=1 STRING: ENSP00000275493
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDCP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDCP1 gene (2 alternative transcripts): 
    NM_022842.4  NM_178181.2  

    Unigene Cluster for CDCP1:

    CUB domain containing protein 1
    Hs.476093  [show with all ESTs]
    Unigene Representative Sequence: NM_022842
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296129(uc003com.3) ENST00000425231(uc003con.3) ENST00000490471

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate CDCP1:
    hsa-miR-3163 hsa-miR-124 hsa-miR-198 hsa-miR-525-5p hsa-miR-506 hsa-miR-944 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDCP1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CDCP1 (NM_178181)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDCP1
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CDCP1
      QuantiFast Probe-based Assays in human, mouse, rat CDCP1

    Additional mRNA sequence: 

    AF468010.1 AK023834.1 AK026187.1 AK026329.1 AK026622.1 AK314441.1 AY026461.1 AY167484.1 
    AY358779.1 AY375452.1 BC021099.1 BC069254.1 

    8 DOTS entries:

    DT.444481  DT.97861092  DT.100787843  DT.95271348  DT.100787841  DT.100787842  DT.426143  DT.97861080 

    Selected AceView cDNA sequences (see all 176):

    BM840669 BQ962997 AA132760 AA922764 BM893567 AI539070 BC021099 NM_178181 
    BM893690 CA307237 BC069254 CB157642 BM701518 AI202358 BM966953 AI420501 
    AA554121 CB129853 AA292689 NM_022842 BM044552 BM840003 BX473477 BM966788 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDCP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTGGTAA
    CDCP1 Expression
    About this image


    CDCP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
             Renal Collecting Duct System
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Hair (Integumentary System)
             Bulge Stem Cells Bulge
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
    CDCP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDCP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.476093

    UniProtKB/Swiss-Prot: CDCP1_HUMAN, Q9H5V8
    Tissue specificity: Highly expressed in mitotic cells with low expression during interphase. Detected at highest
    levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated
    in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also
    expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDCP1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdcp11 , 5 CUB domain containing protein 11, 5 82.51(n)1
    81.27(a)1
      9 (73.92 cM)5
    1093321  NM_133974.31  NP_598735.21 
     1231708245 
    chicken
    (Gallus gallus)
    Aves CDCP11 CUB domain containing protein 1 59.34(n)
    54.17(a)
      420703  XM_418802.4  XP_418802.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDCP16
    CUB domain containing protein 1
    43(a)
    1 ↔ 1
    GL343611.1(212358-284483)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdcp11 CUB domain containing protein 1 53.81(n)
    46.55(a)
      100380031  XM_002938305.1  XP_002938351.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdcp1a1 CUB domain containing protein 1a 41.86(n)
    26.7(a)
      541520  NM_001014333.1  NP_001014355.1 


    ENSEMBL Gene Tree for CDCP1 (if available)
    TreeFam Gene Tree for CDCP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDCP1 (see all 1484)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1417135381,2
    C--45123286(+) GAAAGA/GGGATT 1 -- ds50010--------
    rs1836552721,2
    --45123334(+) AGATAC/TACAGT 1 -- ds50010--------
    rs1890984331,2
    --45123455(+) ATCCAA/GTGTGC 1 -- ds50010--------
    rs1505593921,2
    --45123496(+) GGTGGG/TGGCCA 1 -- ds50010--------
    rs765637811,2
    F--45123527(+) TGCTCT/GCCCTT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1395937651,2
    --45123541(+) TTTTGC/TTCTGG 1 -- ds50010--------
    rs1169855511,2
    C,F--45123593(+) AGTGAT/CTAGGG 1 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1174081421,2
    C,F--45123686(+) GAACAG/AAACAA 1 -- ds50011Minor allele frequency- A:0.03EA 120
    rs1442683691,2
    --45123693(+) ACAAGC/TCCTGG 1 -- ds50010--------
    rs1921099191,2
    --45123818(+) TCTGCC/TTCACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CDCP1 (45123769 - 45187914 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CDCP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725219CNV Deletion23290073
    esv2743358CNV Deletion23290073
    esv1680465CNV Deletion17803354
    nsv512799CNV Insertion21212237
    esv2626441CNV Insertion19546169
    nsv523767CNV Loss19592680
    nsv834676CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611735    OMIM disorders: --

    17 diseases for CDCP1:    
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    clear cell renal cell carcinoma    lung adenocarcinoma    peritonitis    renal cell carcinoma
    pancreatic cancer    adenocarcinoma    colorectal cancer    pancreatitis
    tonsillitis    hypoxia    prostatitis    melanoma
    ovarian cancer    prostate cancer    lung cancer    leukemia
    endotheliitis


    CDCP1 for disorders           About GeneDecksing


    Export disorders for CDCP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDCP1 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with CDCP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. (PubMed id 11466621)1, 2, 3 Scherl-Mostageer M.... Schweifer N. (Oncogene 2001)
    2. Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia. (PubMed id 14739293)1, 2, 9 Brown T.A.... Carter W.G. (J. Biol. Chem. 2004)
    3. Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS. (PubMed id 16404722)1, 2, 9 Andre M.... Le Naour F. (Proteomics 2006)
    4. Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells. (PubMed id 17335815)1, 2 Perry S.E.... Blair G.E. (FEBS Lett. 2007)
    5. The C2 domain of PKCdelta is a phosphotyrosine binding domain. (PubMed id 15851033)1, 2 Benes C.H.... Soltoff S.P. (Cell 2005)
    6. Adhesion signaling by a novel mitotic substrate of src kinases. (PubMed id 16007225)1, 2 Bhatt A.S.... Moasser M.M. (Oncogene 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin. (PubMed id 15153610)1, 2 Buehring H.-J....Lammers R. (Stem Cells 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. CDCP1 is a novel marker for hematopoietic stem cells. (PubMed id 12799299)1, 2 Conze T.... Buehring H.-J. (Ann. N. Y. Acad. Sci. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64866 HGNC: 24357 AceView: CDCP1 Ensembl:ENSG00000163814 euGenes: HUgn64866
    ECgene: CDCP1 H-InvDB: CDCP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDCP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDCP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDCP1 gene:
    Search GeneIP for patents involving CDCP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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