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CDCA8 Gene

protein-coding   GIFtS: 59
GCID: GC01P038158

Cell Division Cycle Associated 8

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle Associated 81 2     DasraB2
borealin1 2     MESRGP2
Cell Division Cycle-Associated Protein 82 3     Dasra B2
Pluripotent Embryonic Stem Cell-Related Gene 3 Protein2 3     dasra-B2
hDasra-B2 3     Dasra-B3
BOR2     PESCRG33
BOREALIN2     

External Ids:    HGNC: 146291   Entrez Gene: 551432   Ensembl: ENSG000001346907   OMIM: 6099775   UniProtKB: Q53HL23   

Export aliases for CDCA8 gene to outside databases

Previous GC identifers: GC01U990479 GC01P037584 GC01P037585 GC01P037827 GC01P037931 GC01P036275


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDCA8 Gene:
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of
mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule
stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of
this gene are found on chromosomes 7, 8 and 16. (provided by RefSeq, Apr 2013)

GeneCards Summary for CDCA8 Gene:
CDCA8 (cell division cycle associated 8) is a protein-coding gene. Diseases associated with CDCA8 include diphyllobothriasis.

UniProtKB/Swiss-Prot: BOREA_HUMAN, Q53HL2
Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.
The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and
segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex,
it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of
attachment-error-correction and chromosome alignment

Gene Wiki entry for CDCA8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDCA8 gene promoter:
         TBP   AML1a   FOXF2   Nkx2-2   FOXD3   FOXL1   YY1   AREB6   Ik-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDCA8 promoter sequence
   Search Chromatin IP Primers for CDCA8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDCA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

CDCA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDCA8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P038158:  view genomic region     (about GC identifiers)

Start:
38,158,090 bp from pter      End:
38,175,391 bp from pter
Size:
17,302 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BOREA_HUMAN, Q53HL2 (See protein sequence)
Recommended Name: Borealin  
Size: 280 amino acids; 31323 Da
Subunit: May form homooligomers and homodimers. Component of the chromosomal passenger complex (CPC) composed of
at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with BIRC5/survivin and INCENP;
interaction is direct. Interacts with SENP3, UBE2I and RANBP2
Developmental stage: Cell-cycle regulated. Increases during G2/M phase and then reduces after exit from M phase
Miscellaneous: Cells lacking CDCA8 display a slight decrease in histone H3 'Ser-10' phosphorylation, suggesting
that the CPC complex mediates phosphorylation of 'Ser-10' of histone H3
Sequence caution: Sequence=BG354581; Type=Frameshift; Positions=123, 200;
4 PDB 3D structures from and Proteopedia for CDCA8:
2KDD (3D)        2QFA (3D)        2RAW (3D)        2RAX (3D)    
Secondary accessions: D3DPT4 Q53HN1 Q96AM3 Q9NVW5

Explore the universe of human proteins at neXtProt for CDCA8: NX_Q53HL2

Explore proteomics data for CDCA8 at MOPED

Post-translational modifications: 

  • Phosphorylated by TTK, essentially at Thr-88, Thr94, Thr-169 and Thr-2301
  • Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO31
  • Ubiquitination2 at Lys37, Lys183
  • Modification sites at PhosphoSitePlus

  • See CDCA8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243804.1  NP_060571.1  

    ENSEMBL proteins: 
     ENSP00000362146   ENSP00000316121  
    Reactome Protein details: Q53HL2

    CDCA8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for CDCA8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018867 Cell_div_borealin
     IPR018851 Borealin-like_N

    Graphical View of Domain Structure for InterPro Entry Q53HL2

    ProtoNet protein and cluster: Q53HL2

    UniProtKB/Swiss-Prot: BOREA_HUMAN, Q53HL2
    Domain: The C-terminal region (aa 207-280) represents the dimerization motif
    Similarity: Belongs to the borealin family


    CDCA8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BOREA_HUMAN, Q53HL2
    Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.
    The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and
    segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex,
    it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of
    attachment-error-correction and chromosome alignment

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16239925
         
    CDCA8 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for CDCA8:
     Abundance of large cells with   Cell division defect  Increased G2M DNA content, inc  Increased cell number in G2M,  
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cdca8):
     cellular  embryogenesis  mortality/aging 

    CDCA8 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDCA8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDCA8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDCA8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDCA8

    miRNA
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    miRTarBase miRNAs that target CDCA8:
    hsa-let-7b-5p (MIRT032429), hsa-mir-16-5p (MIRT031873), hsa-mir-23b-3p (MIRT046299)

    Block miRNA regulation of human, mouse, rat CDCA8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDCA8 (see all 16):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-miR-133b hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDCA8 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CDCA8
    Predesigned siRNA for gene silencing in human, mouse, rat CDCA8

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CDCA8
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    GenScript: all cDNA clones in your preferred vector: CDCA8 (NM_018101)
    Sino Biological Human cDNA Clone for CDCA8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDCA8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCA8

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BOREA_HUMAN, Q53HL2: Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere.
    Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to
    the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in
    interphase cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA15260989
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005819spindle IEA--
    GO:0005825half bridge of spindle pole body ----

    CDCA8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDCA8 About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4Aurora B signaling
    Aurora B signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CDCA8
        Aurora B signaling


    3 Reactome Pathways for CDCA8
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids



    CDCA8 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDCA8
    Interactions:

        GeneGlobe Interaction Network for CDCA8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDCA8 (Q53HL21, 2, 3 ENSP000003161214) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INCENPQ9NQS71, 3, ENSP000003782954EBI-979174,EBI-307907 I2D: score=3 STRING: ENSP00000378295
    BIRC5O153921, 2, 3, ENSP000003016334EBI-979174,EBI-518823 MINT-4509524 MINT-4509575 I2D: score=4 STRING: ENSP00000301633
    AURKBQ96GD43, ENSP000003139504I2D: score=3 STRING: ENSP00000313950
    RANBP2P497923, ENSP000002831954I2D: score=1 STRING: ENSP00000283195
    TTKP339813, ENSP000002305104I2D: score=1 STRING: ENSP00000230510
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000089mitotic metaphase IMP15260989
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0051276chromosome organization IMP15260989

    CDCA8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDCA8 (BOREA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDCA8 gene (2 alternative transcripts): 
    NM_001256875.1  NM_018101.3  

    Unigene Cluster for CDCA8:

    Cell division cycle associated 8
    Hs.524571  [show with all ESTs]
    Unigene Representative Sequence: NM_001256875
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373055(uc001cbr.3 uc001cbs.3) ENST00000327331(uc010oih.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat CDCA8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDCA8 (see all 16):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-miR-133b hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmidCDCA8 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDCA8 (NM_018101)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDCA8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCA8
    Primer
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    OriGene qPCR primer pairs and template standards for CDCA8
    OriGene qSTAR qPCR primer pairs in human, mouse for CDCA8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDCA8
      QuantiTect SYBR Green Assays in human, mouse, rat CDCA8
      QuantiFast Probe-based Assays in human, mouse, rat CDCA8

    Additional mRNA sequence: 

    AK001330.1 AK022104.1 AK022606.1 AK026423.1 AK222549.1 AK222568.1 AK291917.1 AK302116.1 
    AY508815.2 BC000703.2 BC001651.2 BC008079.2 BC016944.1 

    14 DOTS entries:

    DT.86855043  DT.95185842  DT.100791825  DT.100791824  DT.40131843  DT.95185840  DT.100791827  DT.121373422 
    DT.406838  DT.121373411  DT.121373415  DT.91751192  DT.97822510  DT.95185839 

    Selected AceView cDNA sequences (see all 257):

    BC001651 AA455644 AK001330 AY508815 BU158937 BE293644 BQ212996 AU121041 
    AL045680 AA128908 AU131790 AK022606 BM478750 CR617852 AI864425 BQ962264 
    BC008079 AK022104 BQ059503 AW402994 CB159504 BM468233 AU131379 AI309531 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDCA8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                            -                                       
    SP2:                                            -                                       
    SP3:                                                                                    
    SP4:                          -                                                         


    ECgene alternative splicing isoforms for CDCA8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDCA8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGGCTCTC
    CDCA8 Expression
    About this image


    CDCA8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CDCA8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDCA8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524571
        Custom PCR Arrays for CDCA8
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDCA8
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDCA8
    QuantiTect SYBR Green Assays in human, mouse, rat CDCA8
    QuantiFast Probe-based Assays in human, mouse, rat CDCA8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDCA8 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdca81 , 5 cell division cycle associated 81, 5 81.71(n)1
    79.06(a)1
      4 (57.93 cM)5
    522761  NM_026560.41  NP_080836.31 
     1249184655 
    chicken
    (Gallus gallus)
    Aves CDCA86
    cell division cycle associated 8
    44(a)
    1 ↔ 1
    AADN03023297.1(98-4230)
    lizard
    (Anolis carolinensis)
    Reptilia CDCA86
    cell division cycle associated 8
    39(a)
    1 ↔ 1
    GL344018.1(104305-118500)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdca81 cell division cycle associated 8 52.56(n)
    43.82(a)
      444885  NM_001002902.1  NP_001002902.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdca81 cell division cycle associated 8 48.62(n)
    37.59(a)
      492815  NM_001007456.1  NP_001007457.1 


    ENSEMBL Gene Tree for CDCA8 (if available)
    TreeFam Gene Tree for CDCA8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDCA8 gene

    CDCA8 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CDCA8
    PGOHUM00000249014 PGOHUM00000245109 PGOHUM00000232710 PGOHUM00000249332


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDCA8 (see all 401)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23066251,2
    C,F,A,H--38158211(-) GCTGTG/ACCAGT 2 -- ut51 ese323Minor allele frequency- A:0.48EA NS NA WA CSA 3828
    rs1901053581,2
    --38158231(+) CTCAGC/GCCTTG 2 -- ut510--------
    rs1509954191,2
    --38158240(+) TGTCTA/CGGGAC 2 -- ut510--------
    rs1816771751,2
    --38158254(+) AGGTAA/CGTGCC 2 -- ut51 int10--------
    rs115588511,2
    C,F--38158258(+) ACGTGC/TCTGGC 2 -- ut51 int1 ese37Minor allele frequency- T:0.12NA WA 248
    rs115588531,2
    C,F--38158345(+) CCCCGC/TAGCCT 2 -- ut51 int1 ese31Minor allele frequency- T:0.05WA 118
    rs1481680221,2
    C--38158647(+) TACAAC/TATCGA 4 N syn11Minor allele frequency- T:0.00NA 4552
    rs1420038031,2
    C--38158684(+) GCGAGA/GTGAAC 4 M V mis11Minor allele frequency- G:0.00NA 4552
    rs1857089051,2
    --38158781(+) GGCTCG/TCTCAG 2 -- int10--------
    rs1909085421,2
    --38158905(+) GGGGGG/TCGGCG 2 -- int10--------

    HapMap Linkage Disequilibrium report for CDCA8 (38158090 - 38175391 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDCA8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834746CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDCA8
    DNA2.0 Custom Variant and Variant Library Synthesis for CDCA8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609977    OMIM disorders: --

    1 disease for CDCA8:    
    About MalaCards
    diphyllobothriasis

    1 disease from the University of Copenhagen DISEASES database for CDCA8:
    Diphyllobothriasis

    CDCA8 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CDCA8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 16427043 (1)


    Export disorders for CDCA8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDCA8 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with CDCA8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. (PubMed id 15260989)1, 2, 3 Sampath S.C....Funabiki H. (Cell 2004)
    2. Drug target discovery by gene expression analysis: cell cycle genes. (PubMed id 12188893)1, 2, 3 Walker M.G. (Curr. Cancer Drug Targets 2001)
    3. RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation- deconjugation cycle on Borealin. (PubMed id 18946085)1, 2, 9 Klein U.R.... Muller S. (Mol. Biol. Cell 2009)
    4. Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. (PubMed id 16427043)1, 2, 9 Chang J.-L.... Chen C.-M. (Exp. Cell Res. 2006)
    5. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. (PubMed id 15249581)1, 2, 9 Gassmann R.... Earnshaw W.C. (J. Cell Biol. 2004)
    6. Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation. (PubMed id 19530738)1, 2, 9 Bourhis E.... Cochran A.G. (Biochemistry 2009)
    7. Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown. (PubMed id 16547492)1, 2, 9 Rodriguez J.A.... Giaccone G. (Oncogene 2006)
    8. Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of borealin, survivin, and the N-terminal domain of INCENP. (PubMed id 16571674)1, 2, 9 Klein U.R.... Gruneberg U. (Mol. Biol. Cell 2006)
    9. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. (PubMed id 18243099)1, 2, 9 Jelluma N.... Kops G.J.P.L. (Cell 2008)
    10. Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. (PubMed id 17956729)1, 2, 9 Jeyaprakash A.A....Conti E. (Cell 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55143 HGNC: 14629 AceView: CDCA8 Ensembl:ENSG00000134690 euGenes: HUgn55143
    ECgene: CDCA8 H-InvDB: CDCA8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDCA8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDCA8 gene:
    Search GeneIP for patents involving CDCA8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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