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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDCA8 Gene

protein-coding   GIFtS: 54
GCID: GC01P038158

cell division cycle associated 8
 Explore 3 diseases affiliated with
CDCA8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDCA8    

Aliases
for CDCA8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cell Division Cycle Associated 81 2     FLJ120421
BOR1 2     BOREALIN2
DasraB1 2     Borealin1
MESRGP1 2     Dasra B2
Cell Division Cycle-Associated Protein 82 3     Dasra-B3
Pluripotent Embryonic Stem Cell-Related Gene 3 Protein2 3     Dasra-B3
HDasra-B1     PESCRG33

External Ids:    HGNC: 146291   Entrez Gene: 551432   Ensembl: ENSG000001346907   OMIM: 6099775   UniProtKB: Q53HL23   

Export aliases for CDCA8 gene to outside databases

Previous GC identifers: GC01U990479 GC01P037584 GC01P037585 GC01P037827 GC01P037931 GC01P036275


Summaries
for CDCA8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDCA8:
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis
and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule
stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this
gene are found on chromosomes 7, 8 and 16. (provided by RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: BOREA_HUMAN, Q53HL2
Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The
CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is
required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to
direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and
chromosome alignment

Gene Wiki entry for CDCA8


Genomic Views
for CDCA8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDCA8 gene promoter:
         TBP   AML1a   FOXF2   Nkx2-2   FOXD3   FOXL1   YY1   AREB6   Ik-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDCA8 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDCA8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDCA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

CDCA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDCA8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P038158:  view genomic region     (about GC identifiers)

Start:
 38,158,090 bp from pter      End:
 38,175,391 bp from pter
Size:
 17,302 bases      Orientation:
 plus strand

Proteins
for CDCA8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BOREA_HUMAN, Q53HL2 (See protein sequence)
Recommended Name: Borealin  
Size: 280 amino acids; 31323 Da
Subunit: May form homooligomers and homodimers. Component of the chromosomal passenger complex (CPC) composed of at
least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with BIRC5/survivin and INCENP; interaction
is direct. Interacts with SENP3, UBE2I and RANBP2
Subcellular location: Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere.
Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the
spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase
cells
Developmental stage: Cell-cycle regulated. Increases during G2/M phase and then reduces after exit from M phase
Miscellaneous: Cells lacking CDCA8 display a slight decrease in histone H3 'Ser-10' phosphorylation, suggesting that
the CPC complex mediates phosphorylation of 'Ser-10' of histone H3
Sequence caution: Sequence=BG354581; Type=Frameshift; Positions=123, 200;
4 PDB 3D structures from and Proteopedia for CDCA8:
2KDD (3D)        2QFA (3D)        2RAW (3D)        2RAX (3D)    
Secondary accessions: D3DPT4 Q53HN1 Q96AM3 Q9NVW5

Explore the universe of human proteins at neXtProt for CDCA8: NX_Q53HL2

Post-translational modifications:

  • Phosphorylated by TTK, essentially at Thr-88, Thr94, Thr-169 and Thr-2301
  • Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO31
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q53HL2

    • CDCA8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243804.1  NP_060571.1  

    ENSEMBL proteins: 
     ENSP00000362146   ENSP00000316121  
    Reactome Protein details: Q53HL2
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for CDCA8
    Uscn Proteins for CDCA8

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA15260989
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005819spindle ----


    CDCA8 for ontologies           About GeneDecksing



    CDCA8 Antibody Products: 
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    Uscn ELISAs and CLIAs for CDCA8

    Protein Domains /
    Families
    for CDCA8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDCA8 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR018867 Cell_div_borealin
     IPR018851 Borealin-like_N

    Graphical View of Domain Structure for InterPro Entry Q53HL2

    ProtoNet protein and cluster: Q53HL2

    UniProtKB/Swiss-Prot: BOREA_HUMAN, Q53HL2
    Domain: The C-terminal region (aa 207-280) represents the dimerization motif
    Similarity: Belongs to the borealin family


    Function
    for CDCA8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BOREA_HUMAN, Q53HL2
    Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The
    CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is
    required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to
    direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and
    chromosome alignment

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDCA8
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate CDCA8 (see all 16):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-miR-133b hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CDCA8 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18243099


    CDCA8 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for CDCA8:
     Abundance of large cells with   Cell division defect  Increased G2M DNA content, inc  Increased cell number in G2M,  
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cdca8):
     cellular  embryogenesis  mortality/aging 

    CDCA8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDCA8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    2Resolution of Sister Chromatid Cohesion
    		Resolution of Sister Chromatid Cohesion1.00
    		Mitotic Prometaphase0.93
    		Kinetochore assembly0.96
    3Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    4Aurora B signaling
    		Aurora B signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for CDCA8 
        Aurora B signaling

    5/10        Reactome Pathways for CDCA8 (see all 10)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase
    Cell Cycle



    CDCA8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDCA8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/88 Interacting proteins for CDCA8 (Q53HL21, 2, 3 ENSP000003161214) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INCENPQ9NQS71, 3, ENSP000003782954EBI-2557781,EBI-307907 I2D: score=3 STRING: ENSP00000378295
    BIRC5O153921, 2, 3, ENSP000003016334EBI-2557781,EBI-979338 MINT-4509524 MINT-4509575 I2D: score=4 STRING: ENSP00000301633
    AURKBQ96GD43, ENSP000003139504I2D: score=3 STRING: ENSP00000313950
    RANBP2P497923, ENSP000002831954I2D: score=1 STRING: ENSP00000283195
    TTKP339813, ENSP000002305104I2D: score=1 STRING: ENSP00000230510
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087M phase of mitotic cell cycle TAS--
    GO:0000089mitotic metaphase IMP15260989
    GO:0000236mitotic prometaphase TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0051276chromosome organization IMP15260989


    CDCA8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDCA8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDCA8
    Search CenterWatch for drugs/clinical trials and news about CDCA8 / BOREA 

    Transcripts
    for CDCA8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDCA8 gene (2 alternative transcripts): 
    NM_001256875.1  NM_018101.3  

    Unigene Cluster for CDCA8:

    Cell division cycle associated 8
    Hs.524571  [show with all ESTs]
    Unigene Representative Sequence: NM_001256875
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373055(uc001cbr.3 uc001cbs.3) ENST00000327331(uc010oih.1)


    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate CDCA8 (see all 16):
    hsa-miR-98 hsa-let-7d hsa-let-7c hsa-miR-133b hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CDCA8 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDCA8 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK001330.1 AK022104.1 AK022606.1 AK026423.1 AK222549.1 AK222568.1 AK291917.1 AK302116.1 
    AY508815.2 BC000703.2 BC001651.2 BC008079.2 BC016944.1 

    14 DOTS entries:

    DT.86855043  DT.95185842  DT.100791825  DT.100791824  DT.40131843  DT.95185840  DT.100791827  DT.121373422 
    DT.406838  DT.121373411  DT.121373415  DT.91751192  DT.97822510  DT.95185839 

    24/257 AceView cDNA sequences (see all 257):

    BQ059503 BQ962264 AA455644 AU121041 BC001651 BE293644 AA926793 AI086227 
    BQ212996 AW402994 BM478750 AI309531 AW780369 BM811342 AA744555 AU124821 
    AI864425 AU132362 AK022606 BU158937 AL045680 CR617852 AU131790 AK022104 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CDCA8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                            -                                       
    SP2:                                            -                                       
    SP3:                                                                                    
    SP4:                          -                                                         


    ECgene alternative splicing isoforms for CDCA8

    Expression
    for CDCA8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDCA8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGGGCTCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDCA8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)

    See CDCA8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDCA8

    SOURCE GeneReport for Unigene cluster: Hs.524571
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    In Situ
    Assay Products:     
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    Orthologs
    for CDCA8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CDCA8 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cdca81 , 5 cell division cycle associated 81, 5 82.07(n)1
    79.78(a)1    		   4 (57.93 cM)5
    522761  NM_026560.41  NP_080836.31 
     1249184655 
    chicken
    (Gallus gallus)    		 Aves CDCA81 cell division cycle associated 8 57.37(n)
    52.4(a)    		   425084  XM_422876.3  XP_422876.3 
    zebrafish
    (Danio rerio)    		 Actinopterygii cdca81 cell division cycle associated 8 49.62(n)
    38.26(a)    		   492815  NM_001007456.1  NP_001007457.1 


    ENSEMBL Gene Tree for CDCA8 (if available)
    TreeFam Gene Tree for CDCA8 (if available) 

    Paralogs
    for CDCA8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDCA8 gene

    CDCA8 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CDCA8
    PGOHUM00000249014 PGOHUM00000245109 PGOHUM00000232710 PGOHUM00000249332


    Genomic Variants
    for CDCA8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/319 NCBI SNPs in CDCA8 are shown (see all 319)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs23066251,2
    		C,F,A,H,--38158211(-) GCTGTG/ACCAGT 2 -- ut51 ese323Minor allele frequency- A:0.48EA NS NA WA CSA 3828
    rs1901053581,2
    		--38158231(+) CTCAGC/GCCTTG 2 -- ut510--------
    rs1509954191,2
    		--38158240(+) TGTCTA/CGGGAC 2 -- ut510--------
    rs1816771751,2
    		--38158254(+) AGGTAA/CGTGCC 2 -- ut51 int10--------
    rs115588511,2
    		C,F,--38158258(+) ACGTGC/TCTGGC 2 -- ut51 int1 ese37Minor allele frequency- T:0.12NA WA 248
    rs115588531,2
    		C,F,--38158345(+) CCCCGC/TAGCCT 2 -- int1 ut51 ese31Minor allele frequency- T:0.05WA 118
    rs1420038031,2
    		C,--38158684(+) GCGAGA/GTGAAC 4 M V mis11Minor allele frequency- G:0.00NA 4552
    rs1857089051,2
    		--38158781(+) GGCTCG/TCTCAG 2 -- int10--------
    rs1909085421,2
    		--38158905(+) GGGGGG/TCGGCG 2 -- int10--------
    rs1839105421,2
    		--38158912(+) GGCGGC/GCGGGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for CDCA8 (38158090 - 38175391 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CDCA8: --

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    Disorders / Diseases
    for CDCA8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDCA8 for disorders           About GeneDecksing

    OMIM gene information: 609977    OMIM disorders: --

    3 diseases for CDCA8:    About MalaCards
    diphyllobothriasis    metastasis efficiency    gastric cancer

    1 disease from the University of Copenhagen DISEASES database for CDCA8:
    Diphyllobothriasis

    1 Novoseek disease relationship for CDCA8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 16427043 (1)


    Export disorders for CDCA8 gene to outside databases

    Publications
    for CDCA8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDCA8 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with CDCA8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. (PubMed id 15260989)1, 2, 3 Sampath S.C....Funabiki H. (2004)
    2. Drug target discovery by gene expression analysis: cell cycle genes. (PubMed id 12188893)1, 2, 3 Walker M.G. (2001)
    3. RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation- deconjugation cycle on Borealin. (PubMed id 18946085)1, 2, 9 Klein U.R.... Muller S. (2009)
    4. Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. (PubMed id 16427043)1, 2, 9 Chang J.-L.... Chen C.-M. (2006)
    5. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. (PubMed id 15249581)1, 2, 9 Gassmann R.... Earnshaw W.C. (2004)
    6. Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation. (PubMed id 19530738)1, 2, 9 Bourhis E.... Cochran A.G. (2009)
    7. Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown. (PubMed id 16547492)1, 2, 9 Rodriguez J.A.... Giaccone G. (2006)
    8. Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of borealin, survivin, and the N-terminal domain of INCENP. (PubMed id 16571674)1, 2, 9 Klein U.R.... Gruneberg U. (2006)
    9. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. (PubMed id 18243099)1, 2, 9 Jelluma N.... Kops G.J.P.L. (2008)
    10. Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. (PubMed id 17956729)1, 2, 9 Jeyaprakash A.A....Conti E. (2007)

    External Searches for CDCA8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CDCA8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55143 HGNC: 14629 AceView: CDCA8 Ensembl:ENSG00000134690 euGenes: HUgn55143
    ECgene: CDCA8 H-InvDB: CDCA8

    Other Databases showing CDCA8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDCA8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDCA8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CDCA8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDCA8 gene:
    Search GeneIP for patents involving CDCA8

    GeneCards and IP:
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