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Aliases for CDCA8 Gene

Aliases for CDCA8 Gene

  • Cell Division Cycle Associated 8 2 3 5
  • Pluripotent Embryonic Stem Cell-Related Gene 3 Protein 3 4
  • Cell Division Cycle-Associated Protein 8 3 4
  • Borealin 2 3
  • HDasra-B 3 4
  • Dasra-B 3 4
  • Dasra B 3
  • PESCRG3 4
  • DasraB 3
  • MESRGP 3
  • BOR 3

External Ids for CDCA8 Gene

Previous GeneCards Identifiers for CDCA8 Gene

  • GC01U990479
  • GC01P037584
  • GC01P037585
  • GC01P037827
  • GC01P037931
  • GC01P038158
  • GC01P036275

Summaries for CDCA8 Gene

Entrez Gene Summary for CDCA8 Gene

  • This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

GeneCards Summary for CDCA8 Gene

CDCA8 (Cell Division Cycle Associated 8) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Metabolism of proteins.

UniProtKB/Swiss-Prot for CDCA8 Gene

  • Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.

Gene Wiki entry for CDCA8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA8 Gene

Genomics for CDCA8 Gene

Regulatory Elements for CDCA8 Gene

Enhancers for CDCA8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F038008 1.4 Ensembl ENCODE 22.4 +320.5 320509 9.3 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC INPP5B CDCA8 SF3A3 RNU6-510P MTF1 ENSG00000230955 YRDC C1orf122 GNL2 C1orf109
GH01F037992 1.7 FANTOM5 Ensembl ENCODE 13.8 +307.8 307826 15.9 HDGF ARNT CREB3L1 ARID4B ZNF2 FOS ZNF263 SP5 JUNB REST FHL3 SF3A3 CDCA8 GNL2 MYCBP SNIP1 INPP5B MEAF6 UTP11 MTF1
GH01F037533 1.4 Ensembl ENCODE 13.8 -157.8 -157769 2.4 HDGF ARNT CREB3L1 ARID4B SIN3A YY1 ZNF766 FOS SP3 JUNB SNIP1 GNL2 SF3A3 FTH1P1 CDCA8 DNALI1 RPS27P9 MEAF6 LINC01137 LOC105378649
GH01F037545 0.7 FANTOM5 23.9 -147.1 -147147 0.2 ZNF740 NR4A1 CEBPB PTRF PTTG1 PYGO2 GTF2A2 RELA IRF9 IRF1 GNL2 CDCA8 MEAF6 C1orf109 ZC3H12A MTF1 GC01P037546 SNIP1
GH01F037844 1.3 FANTOM5 Ensembl 9.8 +153.8 153800 2.8 BCOR HDAC1 IRF2 ESRRA CREB3L1 NFRKB ZMYM3 ZNF316 GATA2 STAT2 MTF1 ZC3H12A INPP5B YRDC C1orf122 ENSG00000233728 C1orf109 CDCA8 FHL3 SNIP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDCA8 on UCSC Golden Path with GeneCards custom track

Promoters for CDCA8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001743843 199 2400 PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for CDCA8 Gene

Chromosome:
1
Start:
37,692,401 bp from pter
End:
37,709,719 bp from pter
Size:
17,319 bases
Orientation:
Plus strand

Genomic View for CDCA8 Gene

Genes around CDCA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA8 Gene

Proteins for CDCA8 Gene

  • Protein details for CDCA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53HL2-BOREA_HUMAN
    Recommended name:
    Borealin
    Protein Accession:
    Q53HL2
    Secondary Accessions:
    • D3DPT4
    • Q53HN1
    • Q96AM3
    • Q9NVW5

    Protein attributes for CDCA8 Gene

    Size:
    280 amino acids
    Molecular mass:
    31323 Da
    Quaternary structure:
    • May form homooligomers and homodimers. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and BIRC5 (PubMed:17956729). Interacts with SENP3, UBE2I and RANBP2. Interacts (phosphorylated) with SGO1 and SGO2; the association is dependent on CDK1.
    Miscellaneous:
    • Cells lacking CDCA8 display a slight decrease in histone H3 Ser-10 phosphorylation, suggesting that the CPC complex mediates phosphorylation of Ser-10 of histone H3.
    SequenceCaution:
    • Sequence=BG354581; Type=Frameshift; Positions=123, 200; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDCA8 Gene

neXtProt entry for CDCA8 Gene

Post-translational modifications for CDCA8 Gene

  • Phosphorylated by TTK, essentially at Thr-88, Thr94, Thr-169 and Thr-230. Phosphorylation (probably by CDK1) promotes targeting of the CPC to centromeric DNA.
  • Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3.
  • Ubiquitination at Lys 37
  • Modification sites at PhosphoSitePlus

Other Protein References for CDCA8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDCA8 Gene

Domains & Families for CDCA8 Gene

Gene Families for CDCA8 Gene

Protein Domains for CDCA8 Gene

Suggested Antigen Peptide Sequences for CDCA8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53HL2

UniProtKB/Swiss-Prot:

BOREA_HUMAN :
  • The C-terminal region (aa 207-280) represents the dimerization motif.
  • Belongs to the borealin family.
Domain:
  • The C-terminal region (aa 207-280) represents the dimerization motif.
Family:
  • Belongs to the borealin family.
genes like me logo Genes that share domains with CDCA8: view

Function for CDCA8 Gene

Molecular function for CDCA8 Gene

UniProtKB/Swiss-Prot Function:
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.

Gene Ontology (GO) - Molecular Function for CDCA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239925
genes like me logo Genes that share ontologies with CDCA8: view
genes like me logo Genes that share phenotypes with CDCA8: view

Animal Models for CDCA8 Gene

MGI Knock Outs for CDCA8:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDCA8

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDCA8 Gene

Localization for CDCA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA8 Gene

Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. {ECO:0000269 PubMed:18946085}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDCA8 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 4
plasma membrane 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDCA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 15260989
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with CDCA8: view

Pathways & Interactions for CDCA8 Gene

genes like me logo Genes that share pathways with CDCA8: view

Pathways by source for CDCA8 Gene

1 BioSystems pathway for CDCA8 Gene

SIGNOR curated interactions for CDCA8 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDCA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007080 mitotic metaphase plate congression IMP 15260989
GO:0016925 protein sumoylation TAS --
genes like me logo Genes that share ontologies with CDCA8: view

Transcripts for CDCA8 Gene

mRNA/cDNA for CDCA8 Gene

Unigene Clusters for CDCA8 Gene

Cell division cycle associated 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CDCA8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3:
SP4: -

Relevant External Links for CDCA8 Gene

GeneLoc Exon Structure for
CDCA8
ECgene alternative splicing isoforms for
CDCA8

Expression for CDCA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CDCA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDCA8 Gene

This gene is overexpressed in Testis (x7.8).

Protein differential expression in normal tissues from HIPED for CDCA8 Gene

This gene is overexpressed in Lung (54.5) and Testis (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDCA8 Gene



Protein tissue co-expression partners for CDCA8 Gene

NURSA nuclear receptor signaling pathways regulating expression of CDCA8 Gene:

CDCA8

SOURCE GeneReport for Unigene cluster for CDCA8 Gene:

Hs.524571
genes like me logo Genes that share expression patterns with CDCA8: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CDCA8 Gene

Orthologs for CDCA8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDCA8 34 35
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia CDCA8 34 35
  • 87.93 (n)
dog
(Canis familiaris)
Mammalia CDCA8 34 35
  • 87.48 (n)
mouse
(Mus musculus)
Mammalia Cdca8 34 16 35
  • 81.71 (n)
rat
(Rattus norvegicus)
Mammalia Cdca8 34
  • 81.12 (n)
oppossum
(Monodelphis domestica)
Mammalia CDCA8 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA8 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDCA8 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDCA8 35
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdca8 34
  • 52.56 (n)
zebrafish
(Danio rerio)
Actinopterygii cdca8 34 35
  • 48.62 (n)
Species where no ortholog for CDCA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCA8 Gene

ENSEMBL:
Gene Tree for CDCA8 (if available)
TreeFam:
Gene Tree for CDCA8 (if available)

Paralogs for CDCA8 Gene

Pseudogenes.org Pseudogenes for CDCA8 Gene

genes like me logo Genes that share paralogs with CDCA8: view

No data available for Paralogs for CDCA8 Gene

Variants for CDCA8 Gene

Sequence variations from dbSNP and Humsavar for CDCA8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1047958 -- 37,709,663(+) TTGTT(C/T)TAATC utr-variant-3-prime
rs10908369 -- 37,697,667(+) TCTAT(A/G)TGTAT intron-variant
rs10908370 -- 37,698,075(+) AAGGA(C/T)CCAGG intron-variant
rs10908371 -- 37,699,715(+) GAGTT(C/T)GAGAC intron-variant
rs10908372 -- 37,707,752(+) TGAGT(G/T)CAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDCA8 Gene

Variant ID Type Subtype PubMed ID
nsv472046 CNV novel sequence insertion 20440878
nsv834746 CNV loss 17160897

Variation tolerance for CDCA8 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDCA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDCA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA8 Gene

Disorders for CDCA8 Gene

Relevant External Links for CDCA8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDCA8

No disorders were found for CDCA8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDCA8 Gene

Publications for CDCA8 Gene

  1. RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation- deconjugation cycle on Borealin. (PMID: 18946085) Klein U.R. … Muller S. (Mol. Biol. Cell 2009) 3 4 22 64
  2. Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation. (PMID: 19530738) Bourhis E. … Cochran A.G. (Biochemistry 2009) 3 4 22 64
  3. Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. (PMID: 18243099) Jelluma N. … Kops G.J.P.L. (Cell 2008) 3 4 22 64
  4. Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. (PMID: 17956729) Jeyaprakash A.A. … Conti E. (Cell 2007) 3 4 22 64
  5. Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. (PMID: 16239925) Vader G. … Lens S.M.A. (EMBO Rep. 2006) 3 4 22 64

Products for CDCA8 Gene

Sources for CDCA8 Gene

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