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Aliases for CDCA8 Gene

Aliases for CDCA8 Gene

  • Cell Division Cycle Associated 8 2 3
  • Pluripotent Embryonic Stem Cell-Related Gene 3 Protein 3 4
  • Cell Division Cycle-Associated Protein 8 3 4
  • HDasra-B 3 4
  • Dasra-B 3 4
  • Borealin 2
  • BOREALIN 3
  • Dasra B 3
  • PESCRG3 4
  • DasraB 3
  • MESRGP 3
  • BOR 3

External Ids for CDCA8 Gene

Summaries for CDCA8 Gene

Entrez Gene Summary for CDCA8 Gene

  • This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

GeneCards Summary for CDCA8 Gene

CDCA8 (Cell Division Cycle Associated 8) is a Protein Coding gene. Diseases associated with CDCA8 include diphyllobothriasis. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CDCA8 Gene

  • Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.

Gene Wiki entry for CDCA8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA8 Gene

Genomics for CDCA8 Gene

Genomic Location for CDCA8 Gene

Start:
37,692,401 bp from pter
End:
37,709,719 bp from pter
Size:
17,319 bases
Orientation:
Plus strand

Genomic View for CDCA8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDCA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA8 Gene

Regulatory Elements for CDCA8 Gene

Proteins for CDCA8 Gene

  • Protein details for CDCA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53HL2-BOREA_HUMAN
    Recommended name:
    Borealin
    Protein Accession:
    Q53HL2
    Secondary Accessions:
    • D3DPT4
    • Q53HN1
    • Q96AM3
    • Q9NVW5

    Protein attributes for CDCA8 Gene

    Size:
    280 amino acids
    Molecular mass:
    31323 Da
    Quaternary structure:
    • May form homooligomers and homodimers. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with BIRC5/survivin and INCENP; interaction is direct. Interacts with SENP3, UBE2I and RANBP2.
    Miscellaneous:
    • Cells lacking CDCA8 display a slight decrease in histone H3 Ser-10 phosphorylation, suggesting that the CPC complex mediates phosphorylation of Ser-10 of histone H3
    SequenceCaution:
    • Sequence=BG354581; Type=Frameshift; Positions=123, 200; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDCA8 Gene

neXtProt entry for CDCA8 Gene

Proteomics data for CDCA8 Gene at MOPED

Post-translational modifications for CDCA8 Gene

  • Phosphorylated by TTK, essentially at Thr-88, Thr94, Thr-169 and Thr-230.
  • Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys37 and Lys183

Other Protein References for CDCA8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDCA8 Gene

Domains for CDCA8 Gene

Protein Domains for CDCA8 Gene

UniProtKB/Swiss-Prot:

BOREA_HUMAN
Domain:
  • The C-terminal region (aa 207-280) represents the dimerization motif:
    • Q53HL2
Family:
  • Belongs to the borealin family.:
    • Q53HL2
genes like me logo Genes that share domains with CDCA8: view

No data available for Gene Families for CDCA8 Gene

Function for CDCA8 Gene

Molecular function for CDCA8 Gene

UniProtKB/Swiss-Prot Function: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.

Gene Ontology (GO) - Molecular Function for CDCA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16239925
genes like me logo Genes that share ontologies with CDCA8: view
genes like me logo Genes that share phenotypes with CDCA8: view

miRNA for CDCA8 Gene

miRTarBase miRNAs that target CDCA8

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDCA8 Gene

Localization for CDCA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA8 Gene

Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDCA8 Gene COMPARTMENTS Subcellular localization image for CDCA8 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDCA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 15260989
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDCA8: view

Pathways for CDCA8 Gene

genes like me logo Genes that share pathways with CDCA8: view

Pathways by source for CDCA8 Gene

1 BioSystems pathway for CDCA8 Gene

Gene Ontology (GO) - Biological Process for CDCA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007080 mitotic metaphase plate congression IMP 15260989
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051276 chromosome organization IMP 15260989
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDCA8: view

Transcripts for CDCA8 Gene

mRNA/cDNA for CDCA8 Gene

Unigene Clusters for CDCA8 Gene

Cell division cycle associated 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3:
SP4: -

Relevant External Links for CDCA8 Gene

GeneLoc Exon Structure for
CDCA8
ECgene alternative splicing isoforms for
CDCA8

Expression for CDCA8 Gene

mRNA expression in normal human tissues for CDCA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDCA8 Gene

This gene is overexpressed in Testis (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CDCA8 Gene

SOURCE GeneReport for Unigene cluster for CDCA8 Gene Hs.524571

genes like me logo Genes that share expressions with CDCA8: view

Orthologs for CDCA8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDCA8 36
  • 99.29 (n)
  • 99.29 (a)
CDCA8 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDCA8 36
  • 87.93 (n)
  • 87.81 (a)
CDCA8 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDCA8 36
  • 87.48 (n)
  • 87.36 (a)
CDCA8 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdca8 36
  • 81.71 (n)
  • 79.06 (a)
Cdca8 16
Cdca8 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDCA8 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA8 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdca8 36
  • 81.12 (n)
  • 79.57 (a)
chicken
(Gallus gallus)
Aves CDCA8 37
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDCA8 37
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdca8 36
  • 52.56 (n)
  • 43.82 (a)
zebrafish
(Danio rerio)
Actinopterygii cdca8 36
  • 48.62 (n)
  • 37.59 (a)
cdca8 37
  • 34 (a)
OneToOne
Species with no ortholog for CDCA8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCA8 Gene

ENSEMBL:
Gene Tree for CDCA8 (if available)
TreeFam:
Gene Tree for CDCA8 (if available)

Paralogs for CDCA8 Gene

Pseudogenes.org Pseudogenes for CDCA8 Gene

genes like me logo Genes that share paralogs with CDCA8: view

No data available for Paralogs for CDCA8 Gene

Variants for CDCA8 Gene

Sequence variations from dbSNP and Humsavar for CDCA8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7822 -- 37,709,315(+) AGGGG(C/T)GGGTG utr-variant-3-prime
rs13671 -- 37,709,652(-) TCAGC(A/C)TCAAA utr-variant-3-prime
rs497705 -- 37,697,088(-) GTGTG(C/G)TAACA intron-variant
rs498777 -- 37,697,243(+) tgggg(C/T)tcagc intron-variant
rs513826 -- 37,700,350(+) GATTG(C/T)GTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDCA8 Gene

Variant ID Type Subtype PubMed ID
nsv834746 CNV Loss 17160897

Relevant External Links for CDCA8 Gene

HapMap Linkage Disequilibrium report
CDCA8

Disorders for CDCA8 Gene

(1) MalaCards Diseases for CDCA8 Gene

Search for CDCA8 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CDCA8 Gene

(1) Novoseek inferred disease relationships for CDCA8 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1
genes like me logo Genes that share disorders with CDCA8: view

No data available for UniProtKB/Swiss-Prot for CDCA8 Gene

Publications for CDCA8 Gene

  1. Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. (PMID: 16239925) Vader G. … Lens S.M.A. (EMBO Rep. 2006) 3 4 23
  2. Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis. (PMID: 16291752) Noton E.A. … Wheatley S.P. (J. Biol. Chem. 2006) 3 4 23
  3. Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer. (PMID: 16427043) Chang J.-L. … Chen C.-M. (Exp. Cell Res. 2006) 3 4 23
  4. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. (PMID: 15249581) Gassmann R. … Earnshaw W.C. (J. Cell Biol. 2004) 3 4 23
  5. Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown. (PMID: 16547492) Rodriguez J.A. … Giaccone G. (Oncogene 2006) 3 4 23

Products for CDCA8 Gene

Sources for CDCA8 Gene

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