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Aliases for CDCA7L Gene

Aliases for CDCA7L Gene

  • Cell Division Cycle Associated 7 Like 2 3
  • Cell Division Cycle Associated 7-Like 2 3 5
  • Transcription Factor RAM2 3 4
  • JPO2 3 4
  • R1 3 4
  • Protein JPO2 4
  • RAM2 3
  • HR1 4

External Ids for CDCA7L Gene

Previous GeneCards Identifiers for CDCA7L Gene

  • GC07M021714
  • GC07M021907

Summaries for CDCA7L Gene

GeneCards Summary for CDCA7L Gene

CDCA7L (Cell Division Cycle Associated 7 Like) is a Protein Coding gene. Diseases associated with CDCA7L include medulloblastoma and epidural abscess. Among its related pathways are SIDS Susceptibility Pathways. An important paralog of this gene is CDCA7.

UniProtKB/Swiss-Prot for CDCA7L Gene

  • Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

Gene Wiki entry for CDCA7L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA7L Gene

Genomics for CDCA7L Gene

Regulatory Elements for CDCA7L Gene

Promoters for CDCA7L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CDCA7L on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CDCA7L gene promoter:

Genomic Location for CDCA7L Gene

Chromosome:
7
Start:
21,900,899 bp from pter
End:
21,946,084 bp from pter
Size:
45,186 bases
Orientation:
Minus strand

Genomic View for CDCA7L Gene

Genes around CDCA7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCA7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCA7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA7L Gene

Proteins for CDCA7L Gene

  • Protein details for CDCA7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GN5-CDA7L_HUMAN
    Recommended name:
    Cell division cycle-associated 7-like protein
    Protein Accession:
    Q96GN5
    Secondary Accessions:
    • A4D141
    • A6NF50
    • B3KTR5
    • B4DUT3
    • C9K0Y1
    • Q6PIL4
    • Q86YT0
    • Q8IXN5
    • Q96C70
    • Q9H9A2
    • Q9NPV2

    Protein attributes for CDCA7L Gene

    Size:
    454 amino acids
    Molecular mass:
    52206 Da
    Quaternary structure:
    • Interacts with MYC and PSIP1.
    Miscellaneous:
    • Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.
    SequenceCaution:
    • Sequence=BAB14330.1; Type=Frameshift; Positions=260; Evidence={ECO:0000305};

    Alternative splice isoforms for CDCA7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDCA7L Gene

Proteomics data for CDCA7L Gene at MOPED

Post-translational modifications for CDCA7L Gene

  • Ubiquitination at Lys 63, Lys 280, Lys 347, and Lys 440
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CDCA7L Gene

Domains & Families for CDCA7L Gene

Protein Domains for CDCA7L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDCA7L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CDCA7L Gene

Function for CDCA7L Gene

Molecular function for CDCA7L Gene

UniProtKB/Swiss-Prot Function:
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
UniProtKB/Swiss-Prot Induction:
By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.

Phenotypes for CDCA7L Gene

genes like me logo Genes that share phenotypes with CDCA7L: view

Animal Model Products

miRNA for CDCA7L Gene

miRTarBase miRNAs that target CDCA7L

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDCA7L Gene

Localization for CDCA7L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA7L Gene

Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDCA7L Gene COMPARTMENTS Subcellular localization image for CDCA7L gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CDCA7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CDCA7L: view

Pathways & Interactions for CDCA7L Gene

SuperPathways for CDCA7L Gene

genes like me logo Genes that share pathways with CDCA7L: view

Pathways by source for CDCA7L Gene

1 BioSystems pathway for CDCA7L Gene

Gene Ontology (GO) - Biological Process for CDCA7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 15994933
genes like me logo Genes that share ontologies with CDCA7L: view

No data available for SIGNOR curated interactions for CDCA7L Gene

Drugs & Compounds for CDCA7L Gene

No Compound Related Data Available

Transcripts for CDCA7L Gene

Unigene Clusters for CDCA7L Gene

Cell division cycle associated 7-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA7L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for CDCA7L Gene

GeneLoc Exon Structure for
CDCA7L
ECgene alternative splicing isoforms for
CDCA7L

Expression for CDCA7L Gene

mRNA expression in normal human tissues for CDCA7L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDCA7L Gene

This gene is overexpressed in Fetal ovary (57.5) and Blymphocyte (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDCA7L Gene



SOURCE GeneReport for Unigene cluster for CDCA7L Gene Hs.744069

mRNA Expression by UniProt/SwissProt for CDCA7L Gene

Q96GN5-CDA7L_HUMAN
Tissue specificity: Ubiquitous. Overexpressed in medulloblastoma.
genes like me logo Genes that share expression patterns with CDCA7L: view

Protein tissue co-expression partners for CDCA7L Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDCA7L Gene

Orthologs for CDCA7L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA7L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDCA7L 35
  • 86.41 (n)
  • 87.75 (a)
CDCA7L 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDCA7L 35
  • 87.2 (n)
  • 88.96 (a)
CDCA7L 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdca7l 35
  • 80.2 (n)
  • 80.5 (a)
Cdca7l 16
Cdca7l 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDCA7L 35
  • 99.34 (n)
  • 99.12 (a)
CDCA7L 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdca7l 35
  • 80.92 (n)
  • 80 (a)
oppossum
(Monodelphis domestica)
Mammalia CDCA7L 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA7L 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDCA7L 35
  • 66.96 (n)
  • 68.99 (a)
CDCA7L 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDCA7L 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdca7l 35
  • 64.29 (n)
  • 66.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4910 35
zebrafish
(Danio rerio)
Actinopterygii cdca7b 35
  • 52.44 (n)
  • 48.74 (a)
cdca7b 36
  • 41 (a)
OneToOne
Species with no ortholog for CDCA7L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCA7L Gene

ENSEMBL:
Gene Tree for CDCA7L (if available)
TreeFam:
Gene Tree for CDCA7L (if available)

Paralogs for CDCA7L Gene

Paralogs for CDCA7L Gene

(1) SIMAP similar genes for CDCA7L Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CDCA7L Gene

genes like me logo Genes that share paralogs with CDCA7L: view

Variants for CDCA7L Gene

Sequence variations from dbSNP and Humsavar for CDCA7L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs35281045 - 21,908,250(+) ACCTG(G/T)CTACA reference, missense
rs1128250 -- 21,916,787(-) AGCTG(C/T)GATAG reference, synonymous-codon
rs1406705 -- 21,924,744(-) GTTTA(A/C)TTTAC intron-variant
rs1406706 -- 21,945,729(+) CAAAG(A/G)GAAGT intron-variant
rs1534769 -- 21,944,864(+) CTCAA(A/T)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDCA7L Gene

Variant ID Type Subtype PubMed ID
nsv830922 CNV Loss 17160897
nsv7393 OTHER Inversion 18451855
esv275068 CNV Loss 21479260

Variation tolerance for CDCA7L Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDCA7L Gene

HapMap Linkage Disequilibrium report
CDCA7L
Human Gene Mutation Database (HGMD)
CDCA7L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA7L Gene

Disorders for CDCA7L Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDCA7L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
medulloblastoma
  • medulloblastoma, desmoplastic
epidural abscess
  • abscess epidural
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDCA7L

Genetic Association Database (GAD)
CDCA7L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDCA7L
genes like me logo Genes that share disorders with CDCA7L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDCA7L Gene

Publications for CDCA7L Gene

  1. Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. (PMID: 16829576) Ou X.-M. … Shih J.C. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4 67
  2. R1, a novel repressor of the human monoamine oxidase A. (PMID: 15654081) Chen K. … Shih J.C. (J. Biol. Chem. 2005) 3 23
  3. The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells. (PMID: 25480495) Weinhold N. … Hemminki K. (Haematologica 2015) 3
  4. Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin. (PMID: 24634210) Hendrix J. … De Rijck J. (J. Biol. Chem. 2014) 3
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3

Products for CDCA7L Gene

Sources for CDCA7L Gene

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