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Aliases for CDCA7L Gene

Aliases for CDCA7L Gene

  • Cell Division Cycle Associated 7 Like 2 3 5
  • Transcription Factor RAM2 3 4
  • JPO2 3 4
  • R1 3 4
  • Cell Division Cycle-Associated 7-Like Protein 3
  • Cell Division Cycle Associated 7-Like 2
  • Protein JPO2 4
  • RAM2 3
  • HR1 4

External Ids for CDCA7L Gene

Previous GeneCards Identifiers for CDCA7L Gene

  • GC07M021714
  • GC07M021907

Summaries for CDCA7L Gene

GeneCards Summary for CDCA7L Gene

CDCA7L (Cell Division Cycle Associated 7 Like) is a Protein Coding gene. Diseases associated with CDCA7L include Medulloblastoma. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. An important paralog of this gene is CDCA7.

UniProtKB/Swiss-Prot for CDCA7L Gene

  • Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

Gene Wiki entry for CDCA7L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA7L Gene

Genomics for CDCA7L Gene

Regulatory Elements for CDCA7L Gene

Enhancers for CDCA7L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G021938 1.4 Ensembl ENCODE dbSUPER 23.6 +6.6 6614 2.2 PKNOX1 TBL1XR1 WRNIP1 BMI1 FEZF1 ZBTB40 EGR1 ZNF366 RELB ETV6 CDCA7L IL6 PIR47500
GH07G021771 2.3 VISTA ENCODE 10.3 +173.7 173721 1.2 PKNOX1 ATF1 TAL1 ETV1 CHD7 FOSL1 TCF12 GATA2 NCOR1 TRIM24 CDCA7L LOC100506178 PIR48952 GC07P021597
GH07G021941 1.6 Ensembl ENCODE dbSUPER 12.1 +1.9 1866 5.9 SIN3A FEZF1 ZNF2 YY1 ZNF416 ZNF143 ZNF207 ZNF263 SP3 REST SP4 CDCA7L IL6 PIR47500
GH07G021961 0.5 ENCODE 18.1 -15.0 -15014 0.2 MAFF JUND JUN FOS MAFK CDCA7L GC07P021987
GH07G021965 0.7 ENCODE 12.4 -20.0 -20028 1.6 TBL1XR1 BMI1 ARID3A RELB CREM CHD2 MTA2 NR2F1 BHLHE40 JUNB CDCA7L GC07P021987
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDCA7L on UCSC Golden Path with GeneCards custom track

Promoters for CDCA7L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000209313 684 2001 SIN3A FEZF1 ZNF2 YY1 ZNF416 ZNF143 ZNF207 ZNF263 SP3 REST

Transcription factor binding sites by QIAGEN in the CDCA7L gene promoter:

Genomic Location for CDCA7L Gene

Chromosome:
7
Start:
21,900,899 bp from pter
End:
21,946,084 bp from pter
Size:
45,186 bases
Orientation:
Minus strand

Genomic View for CDCA7L Gene

Genes around CDCA7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDCA7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDCA7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA7L Gene

Proteins for CDCA7L Gene

  • Protein details for CDCA7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GN5-CDA7L_HUMAN
    Recommended name:
    Cell division cycle-associated 7-like protein
    Protein Accession:
    Q96GN5
    Secondary Accessions:
    • A4D141
    • A6NF50
    • B3KTR5
    • B4DUT3
    • C9K0Y1
    • Q6PIL4
    • Q86YT0
    • Q8IXN5
    • Q96C70
    • Q9H9A2
    • Q9NPV2

    Protein attributes for CDCA7L Gene

    Size:
    454 amino acids
    Molecular mass:
    52206 Da
    Quaternary structure:
    • Interacts with MYC and PSIP1.
    Miscellaneous:
    • Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.
    SequenceCaution:
    • Sequence=BAB14330.1; Type=Frameshift; Positions=260; Evidence={ECO:0000305};

    Alternative splice isoforms for CDCA7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDCA7L Gene

Post-translational modifications for CDCA7L Gene

  • Ubiquitination at posLast=6363, posLast=280280, posLast=347347, and Lys440
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CDCA7L Gene

Domains & Families for CDCA7L Gene

Protein Domains for CDCA7L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDCA7L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CDCA7L Gene

Function for CDCA7L Gene

Molecular function for CDCA7L Gene

UniProtKB/Swiss-Prot Function:
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
UniProtKB/Swiss-Prot Induction:
By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.

Gene Ontology (GO) - Molecular Function for CDCA7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CDCA7L: view

Phenotypes for CDCA7L Gene

genes like me logo Genes that share phenotypes with CDCA7L: view

Animal Model Products

CRISPR Products

miRNA for CDCA7L Gene

miRTarBase miRNAs that target CDCA7L

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDCA7L Gene

Localization for CDCA7L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA7L Gene

Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDCA7L gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for CDCA7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA 15994933
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CDCA7L: view

Pathways & Interactions for CDCA7L Gene

genes like me logo Genes that share pathways with CDCA7L: view

Pathways by source for CDCA7L Gene

Gene Ontology (GO) - Biological Process for CDCA7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IDA,IEA 15994933
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CDCA7L: view

No data available for SIGNOR curated interactions for CDCA7L Gene

Drugs & Compounds for CDCA7L Gene

No Compound Related Data Available

Transcripts for CDCA7L Gene

Unigene Clusters for CDCA7L Gene

Cell division cycle associated 7-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA7L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for CDCA7L Gene

GeneLoc Exon Structure for
CDCA7L
ECgene alternative splicing isoforms for
CDCA7L

Expression for CDCA7L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDCA7L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CDCA7L Gene

This gene is overexpressed in Fetal ovary (57.5) and Blymphocyte (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDCA7L Gene



Protein tissue co-expression partners for CDCA7L Gene

NURSA nuclear receptor signaling pathways regulating expression of CDCA7L Gene:

CDCA7L

SOURCE GeneReport for Unigene cluster for CDCA7L Gene:

Hs.744069

mRNA Expression by UniProt/SwissProt for CDCA7L Gene:

Q96GN5-CDA7L_HUMAN
Tissue specificity: Ubiquitous. Overexpressed in medulloblastoma.

Evidence on tissue expression from TISSUES for CDCA7L Gene

  • Lung(4.2)
  • Muscle(4.2)
  • Eye(4.1)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with CDCA7L: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDCA7L Gene

Orthologs for CDCA7L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA7L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDCA7L 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia CDCA7L 34 35
  • 87.2 (n)
cow
(Bos Taurus)
Mammalia CDCA7L 34 35
  • 86.41 (n)
rat
(Rattus norvegicus)
Mammalia Cdca7l 34
  • 80.92 (n)
mouse
(Mus musculus)
Mammalia Cdca7l 34 16 35
  • 80.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA7L 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDCA7L 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDCA7L 34 35
  • 66.96 (n)
lizard
(Anolis carolinensis)
Reptilia CDCA7L 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdca7l 34
  • 64.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4910 34
zebrafish
(Danio rerio)
Actinopterygii cdca7b 34 35
  • 52.44 (n)
Species where no ortholog for CDCA7L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCA7L Gene

ENSEMBL:
Gene Tree for CDCA7L (if available)
TreeFam:
Gene Tree for CDCA7L (if available)

Paralogs for CDCA7L Gene

Paralogs for CDCA7L Gene

(1) SIMAP similar genes for CDCA7L Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CDCA7L Gene

genes like me logo Genes that share paralogs with CDCA7L: view

Variants for CDCA7L Gene

Sequence variations from dbSNP and Humsavar for CDCA7L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs12700325 Likely benign 21,901,821(+) AAAAT(A/G)AAACT downstream-variant-500B, utr-variant-3-prime
rs147454485 Likely benign 21,901,251(+) GAAGC(A/C/G)TAAGG reference, synonymous-codon, utr-variant-3-prime
rs183031009 Likely benign 21,901,109(+) GGACA(A/G)ACAAG reference, missense, utr-variant-3-prime
rs62445901 Likely benign 21,901,443(+) GGTGG(C/G)ACACG utr-variant-3-prime
rs72658840 Likely benign 21,901,250(+) AGAAG(C/T)GTAAG reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CDCA7L Gene

Variant ID Type Subtype PubMed ID
esv275068 CNV loss 21479260
esv3343555 CNV insertion 20981092
esv3571696 CNV loss 25503493
nsv1027453 CNV gain 25217958
nsv7393 OTHER inversion 18451855
nsv830922 CNV loss 17160897

Variation tolerance for CDCA7L Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDCA7L Gene

Human Gene Mutation Database (HGMD)
CDCA7L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDCA7L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA7L Gene

Disorders for CDCA7L Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDCA7L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
medulloblastoma
  • medulloblastoma, desmoplastic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CDCA7L

Genetic Association Database (GAD)
CDCA7L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDCA7L
genes like me logo Genes that share disorders with CDCA7L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDCA7L Gene

Publications for CDCA7L Gene

  1. Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. (PMID: 16829576) Ou X.-M. … Shih J.C. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4 64
  2. R1, a novel repressor of the human monoamine oxidase A. (PMID: 15654081) Chen K. … Shih J.C. (J. Biol. Chem. 2005) 3 4 22 64
  3. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PMID: 20189936) Okada Y. … Kamatani N. (Hum. Mol. Genet. 2010) 3 46 64
  4. Transcriptional co-activator p75 binds and tethers the Myc- interacting protein JPO2 to chromatin. (PMID: 16735438) Maertens G.N. … Engelman A. (J. Cell Sci. 2006) 3 4 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for CDCA7L Gene

Sources for CDCA7L Gene

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