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Aliases for CDCA7L Gene

Aliases for CDCA7L Gene

  • Cell Division Cycle Associated 7-Like 2 3
  • JPO2 3 4 6
  • R1 3 4 6
  • Transcription Factor RAM2 3 4
  • Cell Division Cycle-Associated 7-Like Protein 3
  • Protein JPO2 4
  • RAM2 3
  • HR1 4

External Ids for CDCA7L Gene

Summaries for CDCA7L Gene

GeneCards Summary for CDCA7L Gene

CDCA7L (Cell Division Cycle Associated 7-Like) is a Protein Coding gene. Among its related pathways are SIDS Susceptibility Pathways. An important paralog of this gene is CDCA7.

UniProtKB/Swiss-Prot for CDCA7L Gene

  • Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

Gene Wiki entry for CDCA7L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA7L Gene

Genomics for CDCA7L Gene

Genomic Location for CDCA7L Gene

Start:
21,900,899 bp from pter
End:
21,946,084 bp from pter
Size:
45,186 bases
Orientation:
Minus strand

Genomic View for CDCA7L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDCA7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA7L Gene

Regulatory Elements for CDCA7L Gene

Transcription factor binding sites by QIAGEN in the CDCA7L gene promoter:

Proteins for CDCA7L Gene

  • Protein details for CDCA7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GN5-CDA7L_HUMAN
    Recommended name:
    Cell division cycle-associated 7-like protein
    Protein Accession:
    Q96GN5
    Secondary Accessions:
    • A4D141
    • A6NF50
    • B3KTR5
    • B4DUT3
    • C9K0Y1
    • Q6PIL4
    • Q86YT0
    • Q8IXN5
    • Q96C70
    • Q9H9A2
    • Q9NPV2

    Protein attributes for CDCA7L Gene

    Size:
    454 amino acids
    Molecular mass:
    52206 Da
    Quaternary structure:
    • Interacts with MYC and PSIP1.
    Miscellaneous:
    • Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation
    SequenceCaution:
    • Sequence=BAB14330.1; Type=Frameshift; Positions=260; Evidence={ECO:0000305};

    Alternative splice isoforms for CDCA7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDCA7L Gene

Proteomics data for CDCA7L Gene at MOPED

Post-translational modifications for CDCA7L Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys63, Lys280, Lys347, and Lys440

No data available for DME Specific Peptides for CDCA7L Gene

Domains for CDCA7L Gene

Protein Domains for CDCA7L Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with CDCA7L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CDCA7L Gene

Function for CDCA7L Gene

Molecular function for CDCA7L Gene

UniProtKB/Swiss-Prot Function: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
UniProtKB/Swiss-Prot Induction: By MYC overexpression in a concentration dependent manner in neuroblastoma cell line

Gene Ontology (GO) - Molecular Function for CDCA7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24705354
genes like me logo Genes that share ontologies with CDCA7L: view

miRNA for CDCA7L Gene

miRTarBase miRNAs that target CDCA7L

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDCA7L Gene

Localization for CDCA7L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA7L Gene

Cytoplasm. Nucleus. Note=Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDCA7L Gene COMPARTMENTS Subcellular localization image for CDCA7L gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CDCA7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CDCA7L: view

Pathways for CDCA7L Gene

SuperPathways for CDCA7L Gene

genes like me logo Genes that share pathways with CDCA7L: view

Pathways by source for CDCA7L Gene

1 BioSystems pathway for CDCA7L Gene

Gene Ontology (GO) - Biological Process for CDCA7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation IDA 15994933
genes like me logo Genes that share ontologies with CDCA7L: view

Transcripts for CDCA7L Gene

Unigene Clusters for CDCA7L Gene

Cell division cycle associated 7-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA7L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for CDCA7L Gene

GeneLoc Exon Structure for
CDCA7L
ECgene alternative splicing isoforms for
CDCA7L

Expression for CDCA7L Gene

mRNA expression in normal human tissues for CDCA7L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDCA7L Gene

SOURCE GeneReport for Unigene cluster for CDCA7L Gene Hs.744069

mRNA Expression by UniProt/SwissProt for CDCA7L Gene

Q96GN5-CDA7L_HUMAN
Tissue specificity: Ubiquitous. Overexpressed in medulloblastoma.
genes like me logo Genes that share expressions with CDCA7L: view

Orthologs for CDCA7L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA7L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDCA7L 36
  • 99.34 (n)
  • 99.12 (a)
CDCA7L 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDCA7L 36
  • 86.41 (n)
  • 87.75 (a)
CDCA7L 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDCA7L 36
  • 87.2 (n)
  • 88.96 (a)
CDCA7L 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdca7l 36
  • 80.2 (n)
  • 80.5 (a)
Cdca7l 16
Cdca7l 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDCA7L 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA7L 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdca7l 36
  • 80.92 (n)
  • 80 (a)
chicken
(Gallus gallus)
Aves CDCA7L 36
  • 66.96 (n)
  • 68.99 (a)
CDCA7L 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDCA7L 37
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4910 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cdca7l 36
  • 64.29 (n)
  • 66.02 (a)
zebrafish
(Danio rerio)
Actinopterygii cdca7b 36
  • 52.44 (n)
  • 48.74 (a)
cdca7b 37
  • 41 (a)
OneToOne
Species with no ortholog for CDCA7L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCA7L Gene

ENSEMBL:
Gene Tree for CDCA7L (if available)
TreeFam:
Gene Tree for CDCA7L (if available)

Paralogs for CDCA7L Gene

Paralogs for CDCA7L Gene

Selected SIMAP similar genes for CDCA7L Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CDCA7L Gene

genes like me logo Genes that share paralogs with CDCA7L: view

Variants for CDCA7L Gene

Sequence variations from dbSNP and Humsavar for CDCA7L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1128250 -- 21,916,787(-) AGCTG(C/T)GATAG reference, synonymous-codon
rs1406705 -- 21,924,744(-) GTTTA(A/C)TTTAC intron-variant
rs1406706 -- 21,945,729(+) CAAAG(A/G)GAAGT intron-variant
rs1534769 -- 21,944,864(+) CTCAA(A/T)AAAAC intron-variant
rs1581694 -- 21,927,361(-) attct(A/G)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDCA7L Gene

Variant ID Type Subtype PubMed ID
nsv830922 CNV Loss 17160897
nsv7393 OTHER Inversion 18451855
esv275068 CNV Loss 21479260

Relevant External Links for CDCA7L Gene

HapMap Linkage Disequilibrium report
CDCA7L
Human Gene Mutation Database (HGMD)
CDCA7L

Disorders for CDCA7L Gene

Relevant External Links for CDCA7L

Genetic Association Database (GAD)
CDCA7L
genes like me logo Genes that share disorders with CDCA7L: view

No data available for UniProtKB/Swiss-Prot for CDCA7L Gene

Publications for CDCA7L Gene

  1. R1, a novel repressor of the human monoamine oxidase A. (PMID: 15654081) Chen K. … Shih J.C. (J. Biol. Chem. 2005) 3 4 23
  2. Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. (PMID: 16829576) Ou X.-M. … Shih J.C. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1. (PMID: 16728402) Ou X.-M. … Shih J.C. (J. Biol. Chem. 2006) 3 4
  5. Transcriptional co-activator p75 binds and tethers the Myc- interacting protein JPO2 to chromatin. (PMID: 16735438) Maertens G.N. … Engelman A. (J. Cell Sci. 2006) 3 4

Products for CDCA7L Gene

Sources for CDCA7L Gene

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