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Aliases for CDCA7 Gene

Aliases for CDCA7 Gene

  • Cell Division Cycle Associated 7 2 3
  • JPO1 3 4
  • Cell Division Cycle Associated Protein 7 3
  • C-Myc Target JPO1 3
  • Protein JPO1 4

External Ids for CDCA7 Gene

Previous GeneCards Identifiers for CDCA7 Gene

  • GC02P172272
  • GC02P172880
  • GC02P174183
  • GC02P174422
  • GC02P174045
  • GC02P173927
  • GC02P166100

Summaries for CDCA7 Gene

Entrez Gene Summary for CDCA7 Gene

  • This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDCA7 Gene

CDCA7 (Cell Division Cycle Associated 7) is a Protein Coding gene. Diseases associated with CDCA7 include immunodeficiency, centromere instability and facial anomalies syndrome. Among its related pathways are Validated targets of C-MYC transcriptional activation. An important paralog of this gene is CDCA7L.

UniProtKB/Swiss-Prot for CDCA7 Gene

  • Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.

Gene Wiki entry for CDCA7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDCA7 Gene

Genomics for CDCA7 Gene

Regulatory Elements for CDCA7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDCA7 Gene

Chromosome:
2
Start:
173,354,017 bp from pter
End:
173,368,997 bp from pter
Size:
14,981 bases
Orientation:
Plus strand

Genomic View for CDCA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDCA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDCA7 Gene

Proteins for CDCA7 Gene

  • Protein details for CDCA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWT1-CDCA7_HUMAN
    Recommended name:
    Cell division cycle-associated protein 7
    Protein Accession:
    Q9BWT1
    Secondary Accessions:
    • B4DLP8
    • B4DV66
    • Q53EW5
    • Q580W9
    • Q658K4
    • Q658N4
    • Q8NBY9
    • Q96BV8
    • Q96SP5

    Protein attributes for CDCA7 Gene

    Size:
    371 amino acids
    Molecular mass:
    42573 Da
    Quaternary structure:
    • Interacts with MYC (via C-terminus), YWHAE and YWHAZ.
    Miscellaneous:
    • CDCA7 expression is correlated with MYC expression in lymphoblastoid, lymphoma and breast cancer cell lines
    SequenceCaution:
    • Sequence=CAH56357.1; Type=Frameshift; Positions=260; Evidence={ECO:0000305};

    Alternative splice isoforms for CDCA7 Gene

neXtProt entry for CDCA7 Gene

Proteomics data for CDCA7 Gene at MOPED

Post-translational modifications for CDCA7 Gene

  • Phosphorylation at Thr-163 promotes interaction with YWHAE and YWHAZ, dissociation from MYC and sequestration in the cytoplasm. In vitro, phosphorylated at Thr-163 by AKT.
  • Ubiquitination at Lys 123, Lys 131, Lys 204, Lys 212, Lys 349, and Lys 364
  • Modification sites at PhosphoSitePlus

Other Protein References for CDCA7 Gene

No data available for DME Specific Peptides for CDCA7 Gene

Domains & Families for CDCA7 Gene

Protein Domains for CDCA7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CDCA7: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CDCA7 Gene

Function for CDCA7 Gene

Molecular function for CDCA7 Gene

UniProtKB/Swiss-Prot Function:
Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.
UniProtKB/Swiss-Prot Induction:
Activated by MYC and possibly E2F1

Phenotypes for CDCA7 Gene

genes like me logo Genes that share phenotypes with CDCA7: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDCA7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CDCA7 Gene

Localization for CDCA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDCA7 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDCA7 Gene COMPARTMENTS Subcellular localization image for CDCA7 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CDCA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11598121
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CDCA7: view

Pathways & Interactions for CDCA7 Gene

genes like me logo Genes that share pathways with CDCA7: view

Pathways by source for CDCA7 Gene

1 BioSystems pathway for CDCA7 Gene

SIGNOR curated interactions for CDCA7 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CDCA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0042127 regulation of cell proliferation IDA 11598121
genes like me logo Genes that share ontologies with CDCA7: view

Drugs & Compounds for CDCA7 Gene

No Compound Related Data Available

Transcripts for CDCA7 Gene

Unigene Clusters for CDCA7 Gene

Cell division cycle associated 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDCA7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDCA7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - -

Relevant External Links for CDCA7 Gene

GeneLoc Exon Structure for
CDCA7
ECgene alternative splicing isoforms for
CDCA7

Expression for CDCA7 Gene

mRNA expression in normal human tissues for CDCA7 Gene

mRNA differential expression in normal tissues according to GTEx for CDCA7 Gene

This gene is overexpressed in Colon - Transverse (x5.1) and Small Intestine - Terminal Ileum (x4.5).

Protein differential expression in normal tissues from HIPED for CDCA7 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CDCA7 Gene



SOURCE GeneReport for Unigene cluster for CDCA7 Gene Hs.470654

mRNA Expression by UniProt/SwissProt for CDCA7 Gene

Q9BWT1-CDCA7_HUMAN
Tissue specificity: Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis.
genes like me logo Genes that share expression patterns with CDCA7: view

Protein tissue co-expression partners for CDCA7 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CDCA7 Gene

Orthologs for CDCA7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDCA7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDCA7 35
  • 85.71 (n)
  • 86.79 (a)
CDCA7 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDCA7 35
  • 90.99 (n)
  • 90.54 (a)
-- 36
  • 87 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cdca7 35
  • 79.55 (n)
  • 81.06 (a)
Cdca7 16
Cdca7 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDCA7 35
  • 99.33 (n)
  • 99.1 (a)
CDCA7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdca7 35
  • 79.2 (n)
  • 79.7 (a)
oppossum
(Monodelphis domestica)
Mammalia CDCA7 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDCA7 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDCA7 35
  • 65.43 (n)
  • 62.62 (a)
CDCA7 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDCA7 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdca7 35
  • 62.77 (n)
  • 62.08 (a)
Str.1379 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.34018 35
zebrafish
(Danio rerio)
Actinopterygii cdca7a 35
  • 58.69 (n)
  • 58.97 (a)
cdca7a 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13340 35
Species with no ortholog for CDCA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDCA7 Gene

ENSEMBL:
Gene Tree for CDCA7 (if available)
TreeFam:
Gene Tree for CDCA7 (if available)

Paralogs for CDCA7 Gene

Paralogs for CDCA7 Gene

(1) SIMAP similar genes for CDCA7 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CDCA7 Gene

genes like me logo Genes that share paralogs with CDCA7: view

Variants for CDCA7 Gene

Sequence variations from dbSNP and Humsavar for CDCA7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1181 -- 173,364,506(-) AAAAA(A/T)TTTCT intron-variant, nc-transcript-variant
rs11078 -- 173,364,394(+) TTCCT(A/G)GCTTT intron-variant, nc-transcript-variant
rs15618 -- 173,364,450(-) CAAAA(C/T)AGAGG intron-variant, nc-transcript-variant
rs767073 -- 173,362,987(+) GCTCA(C/G)AACCA intron-variant
rs767074 -- 173,363,148(+) GTCTC(A/G)TTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDCA7 Gene

Variant ID Type Subtype PubMed ID
nsv834462 CNV Loss 17160897

Variation tolerance for CDCA7 Gene

Residual Variation Intolerance Score: 17.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDCA7 Gene

HapMap Linkage Disequilibrium report
CDCA7
Human Gene Mutation Database (HGMD)
CDCA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDCA7 Gene

Disorders for CDCA7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CDCA7 Gene - From: Orphanet

- elite association
Search CDCA7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDCA7

Genetic Association Database (GAD)
CDCA7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDCA7
genes like me logo Genes that share disorders with CDCA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDCA7 Gene

Publications for CDCA7 Gene

  1. A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation. (PMID: 11598121) Prescott J.E. … Dang C.V. (J. Biol. Chem. 2001) 2 23 67
  2. Bacillus anthracis secretome time course under host-simulated conditions and identification of immunogenic proteins. (PMID: 17662140) Walz A. … DelVecchio V.G. (Proteome Sci 2007) 23 67
  3. Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells. (PMID: 15994933) Huang A. … Penn L.Z. (Cancer Res. 2005) 23 67
  4. Drug target discovery by gene expression analysis: cell cycle genes. (PMID: 12188893) Walker M.G. (Curr. Cancer Drug Targets 2001) 2 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for CDCA7 Gene

Sources for CDCA7 Gene

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