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CDCA7 Gene

protein-coding   GIFtS: 55
GCID: GC02P174183

Cell Division Cycle Associated 7

  See CDCA7-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Division Cycle Associated 71 2
JPO12 3 5
C-Myc Target JPO12
Cell Division Cycle Associated Protein 72
Cell Division Cycle-Associated Protein 72
Protein JPO13

External Ids:    HGNC: 146281   Entrez Gene: 838792   Ensembl: ENSG000001443547   OMIM: 6099375   UniProtKB: Q9BWT13   

Export aliases for CDCA7 gene to outside databases

Previous GC identifers: GC02P172272 GC02P172880 GC02P174422 GC02P174045 GC02P173927 GC02P166100


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDCA7 Gene:
This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of
this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a
transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two
alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Jul
2008)

GeneCards Summary for CDCA7 Gene:
CDCA7 (cell division cycle associated 7) is a protein-coding gene. Diseases associated with CDCA7 include mucinous cystadenocarcinoma. An important paralog of this gene is CDCA7L.

UniProtKB/Swiss-Prot: CDCA7_HUMAN, Q9BWT1
Function: Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and
clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes
to MYC-mediated tumorigenesis. May play a role as transcriptional regulator

Gene Wiki entry for CDCA7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDCA7 gene promoter:
         HOXA9B   HOXA9   C/EBPbeta   AML1a   Meis-1b   FOXL1   MEF-2A   SEF-1 (1)   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDCA7 promoter sequence
   Search Chromatin IP Primers for CDCA7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDCA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

CDCA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDCA7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P174183:  view genomic region     (about GC identifiers)

Start:
174,219,548 bp from pter      End:
174,233,725 bp from pter
Size:
14,178 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDCA7_HUMAN, Q9BWT1 (See protein sequence)
Recommended Name: Cell division cycle-associated protein 7  
Size: 371 amino acids; 42573 Da
Subunit: Interacts with MYC (via C-terminus), YWHAE and YWHAZ
Miscellaneous: CDCA7 expression is correlated with MYC expression in lymphoblastoid, lymphoma and breast cancer
cell lines
Sequence caution: Sequence=CAH56357.1; Type=Frameshift; Positions=260;
Secondary accessions: Q53EW5 Q580W9 Q658K4 Q658N4 Q8NBY9 Q96BV8 Q96SP5
Alternative splicing: 4 isoforms:  Q9BWT1-1   Q9BWT1-2   Q9BWT1-3   Q9BWT1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDCA7: NX_Q9BWT1

Explore proteomics data for CDCA7 at MOPED

Post-translational modifications: 

  • Phosphorylation at Thr-163 promotes interaction with YWHAE and YWHAZ, dissociation from MYC and sequestration in
    the cytoplasm. In vitro, phosphorylated at Thr-163 by AKT1
  • Ubiquitination2 at Lys123, Lys131, Lys204, Lys212, Lys349, Lys364
  • Modification sites at PhosphoSitePlus

  • See CDCA7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_114148.3  NP_665809.1  

    ENSEMBL proteins: 
     ENSP00000272789   ENSP00000306968   ENSP00000386656   ENSP00000386833   ENSP00000390470  
     ENSP00000376348  

    CDCA7 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018866 Znf-4CXXC_R1

    Graphical View of Domain Structure for InterPro Entry Q9BWT1

    ProtoNet protein and cluster: Q9BWT1


    Find genes that share domains with CDCA7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDCA7_HUMAN, Q9BWT1
    Function: Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and
    clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes
    to MYC-mediated tumorigenesis. May play a role as transcriptional regulator
    Induction: Activated by MYC and possibly E2F1

    Animal Models:

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDCA7

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    miRTarBase miRNAs that target CDCA7:
    hsa-mir-24-3p (MIRT030505), hsa-mir-124-3p (MIRT002583), hsa-mir-193b-3p (MIRT016410), hsa-let-7b-5p (MIRT005056), hsa-mir-30b-5p (MIRT023434)

    Block miRNA regulation of human, mouse, rat CDCA7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDCA7 (see all 38):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-30d hsa-miR-124 hsa-miR-30a hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidCDCA7 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDCA7_HUMAN, Q9BWT1: Nucleus. Cytoplasm. Note=Predominantly nuclear with some expression also seen in the
    cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-163
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with CDCA7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDCA7 About    
    See pathways by source

    SuperPathContained pathways About
    1Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation


    1 BioSystems Pathway for CDCA7
        Validated targets of C-MYC transcriptional activation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDCA7
    Interactions:

        GeneGlobe Interaction Network for CDCA7

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CDCA7 (Q9BWT12, 3 ENSP000003069684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8201980 I2D: score=1 STRING: ENSP00000250416
    MYCENSP000003672074STRING: ENSP00000367207
    MAXENSP000003514904STRING: ENSP00000351490
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006915apoptotic process IEA--
    GO:0042127regulation of cell proliferation IDA11598121
    GO:0051301cell division ----

    Find genes that share ontologies with CDCA7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDCA7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDCA7 gene (2 alternative transcripts): 
    NM_031942.4  NM_145810.2  

    Unigene Cluster for CDCA7:

    Cell division cycle associated 7
    Hs.470654  [show with all ESTs]
    Unigene Representative Sequence: AL834186
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347703 ENST00000306721(uc002uic.1 uc002uid.1 uc010zej.1 uc010zek.1)
    ENST00000410101 ENST00000410019 ENST00000496441 ENST00000435616 ENST00000467411
    ENST00000468359 ENST00000392567
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CDCA7 (see all 38):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-30d hsa-miR-124 hsa-miR-30a hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidCDCA7 3' UTR sequence
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDCA7 (NM_001127370)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDCA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCA7
    Primer
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    OriGene qPCR primer pairs and template standards for CDCA7
    OriGene qSTAR qPCR primer pairs in human, mouse for CDCA7
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CDCA7
      QuantiTect SYBR Green Assays in human, mouse, rat CDCA7
      QuantiFast Probe-based Assays in human, mouse, rat CDCA7

    Additional mRNA sequence: 

    AK027628.1 AK027642.1 AK075134.1 AK223524.1 AK297097.1 AK297245.1 AK300949.1 AL833728.1 
    AL834186.1 AY029179.1 BC015124.1 BC027966.1 

    10 DOTS entries:

    DT.453051  DT.100790577  DT.100025817  DT.108039  DT.100790583  DT.75116156  DT.95142161  DT.100790578 
    DT.121013516  DT.121013539 

    Selected AceView cDNA sequences (see all 216):

    AW731659 NM_031942 AA651863 AI879487 AI225213 AA312498 AW614887 BM832911 
    NM_145810 AW157089 AK027642 AW169393 AL833728 AA939106 BM469632 AW162479 
    BU153849 AI346620 BX356676 AA311937 AA469073 CB115494 AA775633 AA465473 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CDCA7 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                      -                                   -           -     -                                 
    SP2:                                      -           -     -     -           -           -     -                                 
    SP3:                                      -           -                       -           -                                       
    SP4:                                      -           -     -                 -                                                   
    SP5:                                      -           -     -     -           -                                                   


    ECgene alternative splicing isoforms for CDCA7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDCA7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGGTATTG
    CDCA7 Expression
    About this image


    CDCA7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Thymus (Hematopoietic System)
             Thymus
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
    CDCA7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDCA7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.470654

    UniProtKB/Swiss-Prot: CDCA7_HUMAN, Q9BWT1
    Tissue specificity: Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of
    tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML)
    blast crisis

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    QuantiFast Probe-based Assays in human, mouse, rat CDCA7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CDCA7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdca71 , 5 cell division cycle associated 71, 5 79.55(n)1
    81.06(a)1
      2 (43.35 cM)5
    669531  NM_025866.31  NP_080142.11 
     724761595 
    chicken
    (Gallus gallus)
    Aves CDCA71 cell division cycle associated 7 65.43(n)
    62.62(a)
      425630  XM_423365.4  XP_423365.4 
    lizard
    (Anolis carolinensis)
    Reptilia CDCA76
    cell division cycle associated 7
    58(a)
    1 ↔ 1
    GL343316.1(1050120-1070733)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.340182 Xenopus laevis transcribed sequence with moderate similarity more 76.31(n)    AW635736.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdca7a1 cell division cycle associated 7a 58.69(n)
    58.97(a)
      550236  NM_001017574.1  NP_001017574.1 


    ENSEMBL Gene Tree for CDCA7 (if available)
    TreeFam Gene Tree for CDCA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDCA7 gene
    CDCA7L2  
    1 SIMAP similar gene for CDCA7 using alignment to 5 protein entries:     CDCA7_HUMAN (see all proteins):
    CDCA7L

    Find genes that share paralogs with CDCA7           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CDCA7
    PGOHUM00000243527 PGOHUM00000236213


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDCA7 (see all 374)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101845581,2
    C,F,H--166115278(+) GCAGAC/GTTTAT 2 -- ds500114Minor allele frequency- G:0.12EA NS NA WA CSA 535
    rs67046451,2
    C,F--174217703(+) cataaG/Agacct 2 -- us2k1 tfbs33Minor allele frequency- A:0.33WA NA 6
    rs1928692191,2
    --174217870(+) GGGAGA/CCATGA 2 -- us2k10--------
    rs1499253241,2
    --174218001(+) ACTTGA/CTTTTT 2 -- us2k10--------
    rs1849009091,2
    --174218166(+) AACACA/GTACAC 2 -- us2k10--------
    rs176932561,2
    C,F,H--174218187(+) TCTTGT/CGCTCC 2 -- us2k115Minor allele frequency- C:0.10NA NS EA WA 1224
    rs1901958421,2
    --174218346(+) AATACG/TTACTG 2 -- us2k10--------
    rs1171992381,2
    C,F--174218429(+) AGCTCT/CTTGTC 2 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1476210891,2
    --174218610(+) TTATTC/TCCCAG 2 -- us2k10--------
    rs1817450081,2
    --174218644(+) AAATGC/TGAATG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDCA7 (174219548 - 174233725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDCA7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834462CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDCA7
    DNA2.0 Custom Variant and Variant Library Synthesis for CDCA7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609937    OMIM disorders: --

    1 disease for CDCA7:    
    About MalaCards
    mucinous cystadenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for CDCA7:
    Mucinous cystadenocarcinoma

    Find genes that share disorders with CDCA7           About GenesLikeMe

    Genetic Association Database (GAD): CDCA7

    Export disorders for CDCA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDCA7 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CDCA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation. (PubMed id 11598121)1, 2, 3, 9 Prescott J.E.... Dang C.V. (J. Biol. Chem. 2001)
    2. Drug target discovery by gene expression analysis: cell cycle genes. (PubMed id 12188893)1, 2, 3 Walker M.G. (Curr. Cancer Drug Targets 2001)
    3. The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation. (PubMed id 23166294)1, 2 Gill R.M....Scheid M.P. (Mol. Cell. Biol. 2013)
    4. JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity. (PubMed id 16580749)1, 2 Goto Y.... Yoshida K. (Biochim. Biophys. Acta 2006)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo. (PubMed id 15994934)1, 2 Osthus R.C.... Dang C.V. (Cancer Res. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)
    10. A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2. (PubMed id 23974705)1 Allen E.K....Sale M.M. (J. Assoc. Res. Otolaryngol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83879 HGNC: 14628 AceView: CDCA7 Ensembl:ENSG00000144354 euGenes: HUgn83879
    ECgene: CDCA7 H-InvDB: CDCA7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDCA7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDCA7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDCA7 gene:
    Search GeneIP for patents involving CDCA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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