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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDCA7 Gene

protein-coding   GIFtS: 55
GCID: GC02P174183

Cell Division Cycle Associated 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cell Division Cycle Associated 71 2
JPO12 3 5
C-Myc Target JPO12
Cell Division Cycle Associated Protein 72
Cell Division Cycle-Associated Protein 72
Protein JPO13

External Ids:    HGNC: 146281   Entrez Gene: 838792   Ensembl: ENSG000001443547   OMIM: 6099375   UniProtKB: Q9BWT13   

Export aliases for CDCA7 gene to outside databases

Previous GC identifers: GC02P172272 GC02P172880 GC02P174422 GC02P174045 GC02P173927 GC02P166100


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDCA7 Gene:
This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of
this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a
transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two
alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Jul
2008)

GeneCards Summary for CDCA7 Gene: 
CDCA7 (cell division cycle associated 7) is a protein-coding gene. Diseases associated with CDCA7 include mucinous cystadenocarcinoma, and cystadenocarcinoma. An important paralog of this gene is CDCA7L.

UniProtKB/Swiss-Prot: CDCA7_HUMAN, Q9BWT1
Function: Participates in MYC-mediated cell transformation; induces anchorage-independent growth and clonogenicity
in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated
tumorigenesis. May play a role as transcriptional regulator

Gene Wiki entry for CDCA7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDCA7 gene promoter:
         HOXA9B   HOXA9   C/EBPbeta   AML1a   Meis-1b   FOXL1   MEF-2A   SEF-1 (1)   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDCA7 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDCA7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDCA7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

CDCA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDCA7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P174183:  view genomic region     (about GC identifiers)

Start:
174,219,548 bp from pter      End:
174,233,725 bp from pter
Size:
14,178 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDCA7_HUMAN, Q9BWT1 (See protein sequence)
Recommended Name: Cell division cycle-associated protein 7  
Size: 371 amino acids; 42573 Da
Subcellular location: Nucleus
Miscellaneous: CDCA7 expression is correlated with MYC expression in lymphoblastoid, lymphoma and breast cancer
cell lines
Sequence caution: Sequence=CAH56357.1; Type=Frameshift; Positions=260;
Secondary accessions: Q53EW5 Q580W9 Q658K4 Q658N4 Q8NBY9 Q96BV8 Q96SP5
Alternative splicing: 4 isoforms:  Q9BWT1-1   Q9BWT1-2   Q9BWT1-3   Q9BWT1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CDCA7: NX_Q9BWT1

Explore proteomics data for CDCA7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BWT1

  • CDCA7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDCA7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_114148.3  NP_665809.1  

    ENSEMBL proteins: 
     ENSP00000272789   ENSP00000306968   ENSP00000386656   ENSP00000386833   ENSP00000390470  
     ENSP00000376348  

    Human Recombinant Protein Products for CDCA7: 
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    Novus Biologicals CDCA7 Protein
    Novus Biologicals CDCA7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDCA7 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11598121

    CDCA7 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CDCA7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR018866 Znf-4CXXC_R1

    Graphical View of Domain Structure for InterPro Entry Q9BWT1

    ProtoNet protein and cluster: Q9BWT1


    CDCA7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDCA7_HUMAN, Q9BWT1
    Function: Participates in MYC-mediated cell transformation; induces anchorage-independent growth and clonogenicity
    in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated
    tumorigenesis. May play a role as transcriptional regulator
    Induction: Activated by MYC and possibly E2F1

    Animal Models:

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       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDCA7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDCA7 
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    miRNA
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    miRTarBase miRNAs that target CDCA7:
    hsa-mir-124 (MIRT002583), hsa-let-7b (MIRT005056)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDCA7
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CDCA7 (see all 38):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-30d hsa-miR-124 hsa-miR-30a hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidCDCA7 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDCA7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation


    1 BioSystems Pathway for CDCA7
        Validated targets of C-MYC transcriptional activation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDCA7

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CDCA7 (Q9BWT12, 3 ENSP000003069684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8201980 I2D: score=1 STRING: ENSP00000250416
    MYCENSP000003672074STRING: ENSP00000367207
    MAXENSP000003514904STRING: ENSP00000351490
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0042127regulation of cell proliferation IDA11598121
    GO:0051301cell division ----

    CDCA7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDCA7

    Search CenterWatch for drugs/clinical trials and news about CDCA7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDCA7 gene (2 alternative transcripts): 
    NM_031942.4  NM_145810.2  

    Unigene Cluster for CDCA7:

    Cell division cycle associated 7
    Hs.470654  [show with all ESTs]
    Unigene Representative Sequence: AL834186
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347703 ENST00000306721(uc002uic.1 uc002uid.1 uc010zej.1 uc010zek.1)
    ENST00000410101 ENST00000410019 ENST00000496441 ENST00000435616 ENST00000467411
    ENST00000468359 ENST00000392567
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDCA7
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CDCA7 (see all 38):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-30d hsa-miR-124 hsa-miR-30a hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidCDCA7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDCA7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDCA7
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDCA7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDCA7
    Sirion Biotech Customized lentivirus for stable overexpression of CDCA7 
                         Customized lentivirus expression plasmids for stable overexpression of CDCA7 
    Primer
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    OriGene qPCR primer pairs and template standards for CDCA7
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDCA7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDCA7

    Additional mRNA sequence: 

    AK027628.1 AK027642.1 AK075134.1 AK223524.1 AK297097.1 AK297245.1 AK300949.1 AL833728.1 
    AL834186.1 AY029179.1 BC015124.1 BC027966.1 

    10 DOTS entries:

    DT.453051  DT.100790577  DT.100025817  DT.108039  DT.100790583  DT.75116156  DT.95142161  DT.100790578 
    DT.121013516  DT.121013539 

    24/216 AceView cDNA sequences (see all 216):

    CR612922 AI674283 AA736861 CB115494 BM472671 AA284818 AI382916 AA465473 
    AA908739 AI879487 BM670073 BM832911 NM_145810 AA406348 BE350612 BQ224360 
    AI979181 AW964009 AW303817 AI225213 AI346620 AW157089 AA469073 AA377328 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CDCA7 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                      -                                   -           -     -                                 
    SP2:                                      -           -     -     -           -           -     -                                 
    SP3:                                      -           -                       -           -                                       
    SP4:                                      -           -     -                 -                                                   
    SP5:                                      -           -     -     -           -                                                   


    ECgene alternative splicing isoforms for CDCA7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDCA7 expression in normal human tissues (normalized intensities)      CDCA7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGGTATTG
    CDCA7 Expression
    About this image


    CDCA7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             Human Cerebellar Astrocytes   
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/ventricle   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See CDCA7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDCA7

    SOURCE GeneReport for Unigene cluster: Hs.470654

    UniProtKB/Swiss-Prot: CDCA7_HUMAN, Q9BWT1
    Tissue specificity: Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of
    tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML)
    blast crisis

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDCA7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDCA7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CDCA7 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdca75 cell division cycle associated 7   --   2 (43.35 cM) 72476159 
    chicken
    (Gallus gallus)
    Aves CDCA71 cell division cycle associated 7 65.43(n)
    62.62(a)
      425630  XM_423365.3  XP_423365.3 
    lizard
    (Anolis carolinensis)
    Reptilia CDCA76
    cell division cycle associated 7
    55(a)
    1 ↔ 1
    GL343316.1(1050120-1070733)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.340182 Xenopus laevis transcribed sequence with moderate similarity more 76.31(n)    AW635736.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdca7a1 cell division cycle associated 7a 58.81(n)
    59.33(a)
      550236  NM_001017574.1  NP_001017574.1 


    ENSEMBL Gene Tree for CDCA7 (if available)
    TreeFam Gene Tree for CDCA7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDCA7 gene
    CDCA7L2  
    1 SIMAP similar gene for CDCA7 using alignment to 5 protein entries:     CDCA7_HUMAN (see all proteins):
    CDCA7L

    CDCA7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CDCA7
    PGOHUM00000243527 PGOHUM00000236213


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/374 SNPs in CDCA7 are shown (see all 374)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101845581,2
    C,F,H--166115278(+) GCAGAC/GTTTAT 2 -- ds500114Minor allele frequency- G:0.12EA NS NA WA CSA 535
    rs67046451,2
    C,F--174217703(+) cataaG/Agacct 2 -- us2k1 tfbs33Minor allele frequency- A:0.33WA NA 6
    rs1928692191,2
    --174217870(+) GGGAGA/CCATGA 2 -- us2k10--------
    rs1499253241,2
    --174218001(+) ACTTGA/CTTTTT 2 -- us2k10--------
    rs1849009091,2
    --174218166(+) AACACA/GTACAC 2 -- us2k10--------
    rs176932561,2
    C,F,H--174218187(+) TCTTGT/CGCTCC 2 -- us2k115Minor allele frequency- C:0.10NA NS EA WA 1224
    rs1901958421,2
    --174218346(+) AATACG/TTACTG 2 -- us2k10--------
    rs1171992381,2
    C,F--174218429(+) AGCTCT/CTTGTC 2 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1476210891,2
    --174218610(+) TTATTC/TCCCAG 2 -- us2k10--------
    rs1817450081,2
    --174218644(+) AAATGC/TGAATG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDCA7 (174219548 - 174233725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CDCA7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834462CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609937    OMIM disorders: --

    5 diseases for CDCA7:    About MalaCards
    mucinous cystadenocarcinoma    cystadenocarcinoma    medulloblastoma    leukemia
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CDCA7:
    Mucinous cystadenocarcinoma

    CDCA7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDCA7

    Export disorders for CDCA7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDCA7 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with CDCA7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation. (PubMed id 11598121)1, 2, 3, 9 Prescott J.E.... Dang C.V. (2001)
    2. Drug target discovery by gene expression analysis: cell cycle genes. (PubMed id 12188893)1, 2, 3 Walker M.G. (2001)
    3. JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity. (PubMed id 16580749)1, 2 Goto Y.... Yoshida K. (2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    5. The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo. (PubMed id 15994934)1, 2 Osthus R.C.... Dang C.V. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Large-scale genotyping identifies 41 new loci associat ed with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (2013)
    9. The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation. (PubMed id 23166294)1 Gill R.M....Scheid M.P. (2013)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83879 HGNC: 14628 AceView: CDCA7 Ensembl:ENSG00000144354 euGenes: HUgn83879
    ECgene: CDCA7 H-InvDB: CDCA7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDCA7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDCA7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDCA7 gene:
    Search GeneIP for patents involving CDCA7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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